-- dump date 20111121_013246 -- class Genbank::CDS -- table cds -- table main -- field 1 id -- field 2 GI -- field 3 GeneID -- field 4 chrom_position -- field 5 chromosome -- field 6 codon_start -- field 7 contig -- field 8 description -- field 9 end_pos -- field 10 gene -- field 11 gene_id -- field 12 name -- field 13 organism -- field 14 product -- field 15 protein_id -- field 16 start_pos -- field 17 strand -- field 18 taxid -- field 19 type -- header -- id GI GeneID chrom_position chromosome codon_start contig description end_pos gene gene_id name organism product protein_id start_pos strand taxid type YP_003065644.1 254558119 8190526 77..247 1 NC_012987.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 247 8190526 p1METDI0001 Methylobacterium extorquens DM4 hypothetical protein YP_003065644.1 77 D 661410 CDS YP_003065645.1 254558120 8190390 244..1008 1 NC_012987.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1008 8190390 p1METDI0002 Methylobacterium extorquens DM4 hypothetical protein YP_003065645.1 244 D 661410 CDS YP_003065646.1 254558121 8190391 1005..2027 1 NC_012987.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2027 8190391 p1METDI0003 Methylobacterium extorquens DM4 hypothetical protein YP_003065646.1 1005 D 661410 CDS YP_003065647.1 254558122 8190392 2024..3010 1 NC_012987.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3010 8190392 p1METDI0004 Methylobacterium extorquens DM4 hypothetical protein YP_003065647.1 2024 D 661410 CDS YP_003065648.1 254558123 8190393 3019..5274 1 NC_012987.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 5274 8190393 p1METDI0005 Methylobacterium extorquens DM4 hypothetical protein YP_003065648.1 3019 D 661410 CDS YP_003065649.1 254558124 8190394 5278..6600 1 NC_012987.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 6600 8190394 p1METDI0006 Methylobacterium extorquens DM4 hypothetical protein YP_003065649.1 5278 D 661410 CDS YP_003065650.1 254558125 8190396 7314..8570 1 NC_012987.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 12383728; Product type f : factor; Replication protein A 8570 rpA2 8190396 rpA2 Methylobacterium extorquens DM4 Replication protein A YP_003065650.1 7314 D 661410 CDS YP_003065651.1 254558126 8190520 8723..9571 1 NC_012987.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 12383728; Product type f : factor; Replication protein B 9571 repB2 8190520 repB2 Methylobacterium extorquens DM4 Replication protein B YP_003065651.1 8723 D 661410 CDS YP_003065652.1 254558127 8190515 9776..10987 1 NC_012987.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8763954; Product type pf : putative factor; replication initiation protein RepC 10987 repC 8190515 repC Methylobacterium extorquens DM4 replication initiation protein RepC YP_003065652.1 9776 D 661410 CDS YP_003065653.1 254558128 8190516 11875..12237 1 NC_012987.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 12237 8190516 p1METDI0011 Methylobacterium extorquens DM4 hypothetical protein YP_003065653.1 11875 D 661410 CDS YP_003065654.1 254558129 8190398 12844..14343 1 NC_012987.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; transposase of ISMdi7, IS21 family (ORF 1) 14343 8190398 p1METDI0013 Methylobacterium extorquens DM4 transposase of ISMdi7, IS21 family (ORF 1) YP_003065654.1 12844 D 661410 CDS YP_003065655.1 254558130 8190399 14340..15182 1 NC_012987.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; transposase of ISMdi7, IS21 family (ORF 2) 15182 8190399 p1METDI0014 Methylobacterium extorquens DM4 transposase of ISMdi7, IS21 family (ORF 2) YP_003065655.1 14340 D 661410 CDS YP_003065656.1 254558131 8190401 complement(16629..18164) 1 NC_012987.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type e : enzyme; transposase of ISMdi2, ISL3 family 18164 8190401 p1METDI0016 Methylobacterium extorquens DM4 transposase of ISMdi2, ISL3 family YP_003065656.1 16629 R 661410 CDS YP_003065657.1 254558132 8190403 complement(18598..19908) 1 NC_012987.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type e : enzyme; transposase of ISMex3, IS256 family 19908 8190403 p1METDI0018 Methylobacterium extorquens DM4 transposase of ISMex3, IS256 family YP_003065657.1 18598 R 661410 CDS YP_003065658.1 254558133 8190511 22671..23045 1 NC_012987.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 23045 8190511 p1METDI0022 Methylobacterium extorquens DM4 hypothetical protein YP_003065658.1 22671 D 661410 CDS YP_003065659.1 254558134 8190407 23042..24733 1 NC_012987.1 Evidence 2b : Function of strongly homologous gene; Product type pt : putative transporter; sodium:solute symporter family protein 24733 actP 8190407 actP Methylobacterium extorquens DM4 sodium:solute symporter family protein YP_003065659.1 23042 D 661410 CDS YP_003065660.1 254558135 8190512 24915..25949 1 NC_012987.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type e : enzyme; transposase of ISMdi11, IS481 family 25949 8190512 p1METDI0024 Methylobacterium extorquens DM4 transposase of ISMdi11, IS481 family YP_003065660.1 24915 D 661410 CDS YP_003065661.1 254558136 8190408 27580..28797 1 NC_012987.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 28797 8190408 p1METDI0025 Methylobacterium extorquens DM4 hypothetical protein YP_003065661.1 27580 D 661410 CDS YP_003065662.1 254558137 8190409 29293..30546 1 NC_012987.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 7719856; Product type e : enzyme; D-3-phosphoglycerate dehydrogenase 30546 serA 8190409 serA Methylobacterium extorquens DM4 D-3-phosphoglycerate dehydrogenase YP_003065662.1 29293 D 661410 CDS YP_003065663.1 254558138 8190521 30566..31993 1 NC_012987.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative D-lactate dehydrogenase (cytochrome) 31993 8190521 p1METDI0027 Methylobacterium extorquens DM4 putative D-lactate dehydrogenase (cytochrome) YP_003065663.1 30566 D 661410 CDS YP_003065664.1 254558139 8190412 33125..34303 1 NC_012987.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 34303 8190412 p1METDI0030 Methylobacterium extorquens DM4 hypothetical protein YP_003065664.1 33125 D 661410 CDS YP_003065665.1 254558140 8190413 34627..35832 1 NC_012987.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; transposase of ISMdi25, IS30 family 35832 8190413 p1METDI0031 Methylobacterium extorquens DM4 transposase of ISMdi25, IS30 family YP_003065665.1 34627 D 661410 CDS YP_003065666.1 254558141 8190415 37078..38136 1 NC_012987.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 7559340; Product type e : enzyme; dTDP-glucose 4,6-dehydratase 38136 rffG 8190415 rffG Methylobacterium extorquens DM4 dTDP-glucose 4,6-dehydratase YP_003065666.1 37078 D 661410 CDS YP_003065667.1 254558142 8190518 38154..39044 1 NC_012987.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; dTDP-4-dehydrorhamnose reductase 39044 rfbD 8190518 rfbD Methylobacterium extorquens DM4 dTDP-4-dehydrorhamnose reductase YP_003065667.1 38154 D 661410 CDS YP_003065668.1 254558143 8190517 39060..39950 1 NC_012987.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 7559340; Product type e : enzyme; Glucose-1-phosphate thymidylyltransferase 39950 rffH 8190517 rffH Methylobacterium extorquens DM4 Glucose-1-phosphate thymidylyltransferase YP_003065668.1 39060 D 661410 CDS YP_003065669.1 254558144 8190519 45402..45692 1 NC_012987.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 45692 8190519 p1METDI0036 Methylobacterium extorquens DM4 hypothetical protein YP_003065669.1 45402 D 661410 CDS YP_003065670.1 254558145 8190418 47301..48806 1 NC_012987.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 48806 8190418 p1METDI0039 Methylobacterium extorquens DM4 hypothetical protein YP_003065670.1 47301 D 661410 CDS YP_003065671.1 254558146 8190419 48955..50313 1 NC_012987.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; transposase of ISMdi28, IS701 family 50313 8190419 p1METDI0040 Methylobacterium extorquens DM4 transposase of ISMdi28, IS701 family YP_003065671.1 48955 D 661410 CDS YP_003065672.1 254558147 8190421 complement(50992..51726) 1 NC_012987.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; transposase of ISMdi27, IS21 family (ORF 2) 51726 8190421 p1METDI0043 Methylobacterium extorquens DM4 transposase of ISMdi27, IS21 family (ORF 2) YP_003065672.1 50992 R 661410 CDS YP_003065673.1 254558148 8190422 complement(51723..53222) 1 NC_012987.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; transposase of ISMdi27, IS21 family (ORF 1) 53222 8190422 p1METDI0044 Methylobacterium extorquens DM4 transposase of ISMdi27, IS21 family (ORF 1) YP_003065673.1 51723 R 661410 CDS YP_003065674.1 254558149 8190428 complement(60183..60542) 1 NC_012987.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 60542 8190428 p1METDI0051 Methylobacterium extorquens DM4 hypothetical protein YP_003065674.1 60183 R 661410 CDS YP_003065675.1 254558150 8190429 complement(60924..61985) 1 NC_012987.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 3486297; Product type pe : putative enzyme; putative Phage integrase (cre-like) 61985 8190429 p1METDI0052 Methylobacterium extorquens DM4 putative Phage integrase (cre-like) YP_003065675.1 60924 R 661410 CDS YP_003065676.1 254558151 8190430 62430..62855 1 NC_012987.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 62855 8190430 p1METDI0053 Methylobacterium extorquens DM4 hypothetical protein YP_003065676.1 62430 D 661410 CDS YP_003065677.1 254558152 8190431 63207..64172 1 NC_012987.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative metallo-hydrolase/oxidoreductase 64172 8190431 p1METDI0054 Methylobacterium extorquens DM4 putative metallo-hydrolase/oxidoreductase YP_003065677.1 63207 D 661410 CDS YP_003065678.1 254558153 8190432 complement(64186..64653) 1 NC_012987.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 64653 8190432 p1METDI0055 Methylobacterium extorquens DM4 hypothetical protein YP_003065678.1 64186 R 661410 CDS YP_003065679.1 254558154 8190434 complement(65022..65495) 1 NC_012987.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 65495 8190434 p1METDI0057 Methylobacterium extorquens DM4 hypothetical protein YP_003065679.1 65022 R 661410 CDS YP_003065680.1 254558155 8190435 complement(65866..66825) 1 NC_012987.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 66825 8190435 p1METDI0059 Methylobacterium extorquens DM4 hypothetical protein YP_003065680.1 65866 R 661410 CDS YP_003065681.1 254558156 8190436 complement(66945..68405) 1 NC_012987.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 8297211; Product type e : enzyme; succinate-semialdehyde dehydrogenase I, NADP-dependent (gabD-like) 68405 8190436 p1METDI0060 Methylobacterium extorquens DM4 succinate-semialdehyde dehydrogenase I, NADP-dependent (gabD-like) YP_003065681.1 66945 R 661410 CDS YP_003065682.1 254558157 8190437 complement(68469..69626) 1 NC_012987.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 2935393; Product type pe : putative enzyme; putative Iron-containing alcohol dehydrogenase 69626 8190437 p1METDI0061 Methylobacterium extorquens DM4 putative Iron-containing alcohol dehydrogenase YP_003065682.1 68469 R 661410 CDS YP_003065683.1 254558158 8190438 complement(69649..70284) 1 NC_012987.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative high-affinity branched-chain amino acid transporter, ATP-binding component of ABC transporter (livF-like) 70284 8190438 p1METDI0062 Methylobacterium extorquens DM4 putative high-affinity branched-chain amino acid transporter, ATP-binding component of ABC transporter (livF-like) YP_003065683.1 69649 R 661410 CDS YP_003065684.1 254558159 8190439 complement(70463..71242) 1 NC_012987.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative high-affinity branched-chain amino acid transporter, ATP-binding component of ABC transporter (livG-like) 71242 8190439 p1METDI0063 Methylobacterium extorquens DM4 putative high-affinity branched-chain amino acid transporter, ATP-binding component of ABC transporter (livG-like) YP_003065684.1 70463 R 661410 CDS YP_003065685.1 254558160 8190440 complement(71239..72219) 1 NC_012987.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative high-affinity branched-chain amino acid transporter, membrane component of ABC transporter (livM-like) 72219 8190440 p1METDI0064 Methylobacterium extorquens DM4 putative high-affinity branched-chain amino acid transporter, membrane component of ABC transporter (livM-like) YP_003065685.1 71239 R 661410 CDS YP_003065686.1 254558161 8190441 complement(72216..73112) 1 NC_012987.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative high-affinity branched-chain amino acid transporter, membrane component of ABC transporter (livH-like) 73112 8190441 p1METDI0065 Methylobacterium extorquens DM4 putative high-affinity branched-chain amino acid transporter, membrane component of ABC transporter (livH-like) YP_003065686.1 72216 R 661410 CDS YP_003065687.1 254558162 8190442 complement(73175..74506) 1 NC_012987.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative ABC transporter, periplasmic protein 74506 8190442 p1METDI0066 Methylobacterium extorquens DM4 putative ABC transporter, periplasmic protein YP_003065687.1 73175 R 661410 CDS YP_003065688.1 254558163 8190443 74651..75385 1 NC_012987.1 Evidence 2b : Function of strongly homologous gene; Product type r : regulator; Regulatory proteins, AttJ 75385 8190443 p1METDI0067 Methylobacterium extorquens DM4 Regulatory proteins, AttJ YP_003065688.1 74651 D 661410 CDS YP_003065689.1 254558164 8190447 complement(77047..78372) 1 NC_012987.1 Evidence 1c : Function experimentally demonstrated in the studied genus; PubMedId : 11114905, 11208803, 11267773, 12898135; Product type e : enzyme; polyhydroxybutanoate depolymerase 78372 dep 8190447 dep Methylobacterium extorquens DM4 polyhydroxybutanoate depolymerase YP_003065689.1 77047 R 661410 CDS YP_003065690.1 254558165 8190514 78696..79139 1 NC_012987.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12399487; putative granule-associated 20 kDa protein 79139 8190514 p1METDI0072 Methylobacterium extorquens DM4 putative granule-associated 20 kDa protein YP_003065690.1 78696 D 661410 CDS YP_003065691.1 254558166 8190449 79959..80801 1 NC_012987.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type e : enzyme; transposase of ISMdi16, IS3 family (ORF 2) 80801 8190449 p1METDI0074 Methylobacterium extorquens DM4 transposase of ISMdi16, IS3 family (ORF 2) YP_003065691.1 79959 D 661410 CDS YP_003065692.1 254558167 8190451 complement(81578..82408) 1 NC_012987.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; transposase of ISMdi26, IS5 family 82408 8190451 p1METDI0076 Methylobacterium extorquens DM4 transposase of ISMdi26, IS5 family YP_003065692.1 81578 R 661410 CDS YP_003065693.1 254558168 8190452 complement(83073..83951) 1 NC_012987.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcriptional regulator, LysR family 83951 8190452 p1METDI0077 Methylobacterium extorquens DM4 putative transcriptional regulator, LysR family YP_003065693.1 83073 R 661410 CDS YP_003065694.1 254558169 8190453 84123..85061 1 NC_012987.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 85061 8190453 p1METDI0078 Methylobacterium extorquens DM4 hypothetical protein YP_003065694.1 84123 D 661410 CDS YP_003065695.1 254558170 8190454 85091..86107 1 NC_012987.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; NADPH quinone oxidoreductase, Zinc-containing alcohol dehydrogenase superfamily 86107 8190454 p1METDI0079 Methylobacterium extorquens DM4 NADPH quinone oxidoreductase, Zinc-containing alcohol dehydrogenase superfamily YP_003065695.1 85091 D 661410 CDS YP_003065696.1 254558171 8190460 89802..91289 1 NC_012987.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative sensory box/GGDEF family protein, putative protein with GAF:PAS/PAC:GGDEF domains 91289 8190460 p1METDI0085 Methylobacterium extorquens DM4 putative sensory box/GGDEF family protein, putative protein with GAF:PAS/PAC:GGDEF domains YP_003065696.1 89802 D 661410 CDS YP_003065697.1 254558172 8190462 92418..93428 1 NC_012987.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type e : enzyme; transposase of ISMex29, IS110 family 93428 8190462 p1METDI0087 Methylobacterium extorquens DM4 transposase of ISMex29, IS110 family YP_003065697.1 92418 D 661410 CDS YP_003065698.1 254558173 8190465 95261..96001 1 NC_012987.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 96001 8190465 p1METDI0090 Methylobacterium extorquens DM4 hypothetical protein YP_003065698.1 95261 D 661410 CDS YP_003065699.1 254558174 8190466 complement(96187..96618) 1 NC_012987.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 96618 8190466 p1METDI0091 Methylobacterium extorquens DM4 hypothetical protein YP_003065699.1 96187 R 661410 CDS YP_003065700.1 254558175 8190467 complement(96663..97094) 1 NC_012987.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 97094 8190467 p1METDI0092 Methylobacterium extorquens DM4 hypothetical protein YP_003065700.1 96663 R 661410 CDS YP_003065701.1 254558176 8190468 complement(97171..97479) 1 NC_012987.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 97479 8190468 p1METDI0093 Methylobacterium extorquens DM4 hypothetical protein YP_003065701.1 97171 R 661410 CDS YP_003065702.1 254558177 8190469 97679..98221 1 NC_012987.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 98221 8190469 p1METDI0094 Methylobacterium extorquens DM4 hypothetical protein YP_003065702.1 97679 D 661410 CDS YP_003065703.1 254558178 8190470 98218..98604 1 NC_012987.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 98604 8190470 p1METDI0095 Methylobacterium extorquens DM4 hypothetical protein YP_003065703.1 98218 D 661410 CDS YP_003065704.1 254558179 8190471 98675..98932 1 NC_012987.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor; putative prevent-host-death protein 98932 8190471 p1METDI0096 Methylobacterium extorquens DM4 putative prevent-host-death protein YP_003065704.1 98675 D 661410 CDS YP_003065705.1 254558180 8190472 98919..99356 1 NC_012987.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 99356 8190472 p1METDI0097 Methylobacterium extorquens DM4 hypothetical protein YP_003065705.1 98919 D 661410 CDS YP_003065706.1 254558181 8190473 99599..99769 1 NC_012987.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 99769 8190473 p1METDI0098 Methylobacterium extorquens DM4 hypothetical protein YP_003065706.1 99599 D 661410 CDS YP_003065707.1 254558182 8190474 99890..100132 1 NC_012987.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 100132 8190474 p1METDI0099 Methylobacterium extorquens DM4 hypothetical protein YP_003065707.1 99890 D 661410 CDS YP_003065708.1 254558183 8190475 100129..100527 1 NC_012987.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 100527 8190475 p1METDI0100 Methylobacterium extorquens DM4 hypothetical protein YP_003065708.1 100129 D 661410 CDS YP_003065709.1 254558184 8190476 100742..101191 1 NC_012987.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 101191 8190476 p1METDI0101 Methylobacterium extorquens DM4 hypothetical protein YP_003065709.1 100742 D 661410 CDS YP_003065710.1 254558185 8190477 101887..102264 1 NC_012987.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 102264 8190477 p1METDI0102 Methylobacterium extorquens DM4 hypothetical protein YP_003065710.1 101887 D 661410 CDS YP_003065711.1 254558186 8190478 102330..102578 1 NC_012987.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 102578 8190478 p1METDI0103 Methylobacterium extorquens DM4 hypothetical protein YP_003065711.1 102330 D 661410 CDS YP_003065712.1 254558187 8190479 102747..103766 1 NC_012987.1 Evidence 2b : Function of strongly homologous gene; Product type f : factor; Antirestriction protein (ardC) 103766 ardC 8190479 ardC Methylobacterium extorquens DM4 Antirestriction protein (ardC) YP_003065712.1 102747 D 661410 CDS YP_003065713.1 254558188 8190513 103766..104752 1 NC_012987.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 104752 8190513 p1METDI0105 Methylobacterium extorquens DM4 hypothetical protein YP_003065713.1 103766 D 661410 CDS YP_003065714.1 254558189 8190480 complement(104785..104985) 1 NC_012987.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 104985 8190480 p1METDI0107 Methylobacterium extorquens DM4 hypothetical protein YP_003065714.1 104785 R 661410 CDS YP_003065715.1 254558190 8190481 105344..105607 1 NC_012987.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 105607 8190481 p1METDI0108 Methylobacterium extorquens DM4 hypothetical protein YP_003065715.1 105344 D 661410 CDS YP_003065716.1 254558191 8190482 105694..106152 1 NC_012987.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 106152 8190482 p1METDI0109 Methylobacterium extorquens DM4 hypothetical protein YP_003065716.1 105694 D 661410 CDS YP_003065717.1 254558192 8190483 106272..108518 1 NC_012987.1 Evidence 2b : Function of strongly homologous gene; Product type f : factor; ParB-like partition protein, plasmid stabilization protein 108518 8190483 p1METDI0110 Methylobacterium extorquens DM4 ParB-like partition protein, plasmid stabilization protein YP_003065717.1 106272 D 661410 CDS YP_003065718.1 254558193 8190484 108806..113161 1 NC_012987.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative methylase/helicase 113161 8190484 p1METDI0111 Methylobacterium extorquens DM4 putative methylase/helicase YP_003065718.1 108806 D 661410 CDS YP_003065719.1 254558194 8190485 113187..114245 1 NC_012987.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 114245 8190485 p1METDI0112 Methylobacterium extorquens DM4 hypothetical protein YP_003065719.1 113187 D 661410 CDS YP_003065720.1 254558195 8190486 114494..115522 1 NC_012987.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 115522 8190486 p1METDI0113 Methylobacterium extorquens DM4 hypothetical protein YP_003065720.1 114494 D 661410 CDS YP_003065721.1 254558196 8190487 complement(115519..115923) 1 NC_012987.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 115923 8190487 p1METDI0114 Methylobacterium extorquens DM4 hypothetical protein YP_003065721.1 115519 R 661410 CDS YP_003065722.1 254558197 8190488 116014..116271 1 NC_012987.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 116271 8190488 p1METDI0115 Methylobacterium extorquens DM4 hypothetical protein YP_003065722.1 116014 D 661410 CDS YP_003065723.1 254558198 8190489 complement(116373..116576) 1 NC_012987.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 116576 8190489 p1METDI0116 Methylobacterium extorquens DM4 hypothetical protein YP_003065723.1 116373 R 661410 CDS YP_003065724.1 254558199 8190490 116811..116984 1 NC_012987.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 116984 8190490 p1METDI0117 Methylobacterium extorquens DM4 hypothetical protein YP_003065724.1 116811 D 661410 CDS YP_003065725.1 254558200 8190491 complement(117189..119213) 1 NC_012987.1 VirD4 family; conjugal transfer coupling protein TraG 119213 traG 8190491 traG Methylobacterium extorquens DM4 conjugal transfer coupling protein TraG YP_003065725.1 117189 R 661410 CDS YP_003065726.1 254558201 8190525 complement(119210..119404) 1 NC_012987.1 Evidence 2b : Function of strongly homologous gene; Product type f : factor; Conjugal transfer protein TraD 119404 traD 8190525 traD Methylobacterium extorquens DM4 Conjugal transfer protein TraD YP_003065726.1 119210 R 661410 CDS YP_003065727.1 254558202 8190524 complement(119391..119669) 1 NC_012987.1 Evidence 2b : Function of strongly homologous gene; Product type f : factor; conjugal transfer protein TraC 119669 traC 8190524 traC Methylobacterium extorquens DM4 conjugal transfer protein TraC YP_003065727.1 119391 R 661410 CDS YP_003065728.1 254558203 8190523 120036..123749 1 NC_012987.1 Evidence 2b : Function of strongly homologous gene; Product type pf : putative factor; TraA conjugal transfer protein 123749 traA 8190523 traA Methylobacterium extorquens DM4 TraA conjugal transfer protein YP_003065728.1 120036 D 661410 CDS YP_003065729.1 254558204 8190522 123861..124181 1 NC_012987.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 124181 8190522 p1METDI0122 Methylobacterium extorquens DM4 hypothetical protein YP_003065729.1 123861 D 661410 CDS YP_003065730.1 254558205 8190492 124178..125479 1 NC_012987.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 125479 8190492 p1METDI0123 Methylobacterium extorquens DM4 hypothetical protein YP_003065730.1 124178 D 661410 CDS YP_003065731.1 254558206 8190493 125476..126396 1 NC_012987.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 126396 8190493 p1METDI0124 Methylobacterium extorquens DM4 hypothetical protein YP_003065731.1 125476 D 661410 CDS YP_003065732.1 254558207 8190494 complement(126870..127280) 1 NC_012987.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 127280 8190494 p1METDI0125 Methylobacterium extorquens DM4 hypothetical protein YP_003065732.1 126870 R 661410 CDS YP_003065733.1 254558208 8190495 complement(127283..130270) 1 NC_012987.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 130270 8190495 p1METDI0126 Methylobacterium extorquens DM4 hypothetical protein YP_003065733.1 127283 R 661410 CDS YP_003065734.1 254558209 8190496 complement(130267..130758) 1 NC_012987.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 130758 8190496 p1METDI0127 Methylobacterium extorquens DM4 hypothetical protein YP_003065734.1 130267 R 661410 CDS YP_003065735.1 254558210 8190497 complement(130748..131002) 1 NC_012987.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 131002 8190497 p1METDI0128 Methylobacterium extorquens DM4 hypothetical protein YP_003065735.1 130748 R 661410 CDS YP_003065736.1 254558211 8190498 complement(130999..132282) 1 NC_012987.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 132282 8190498 p1METDI0129 Methylobacterium extorquens DM4 hypothetical protein YP_003065736.1 130999 R 661410 CDS YP_003065737.1 254558212 8190499 complement(132293..133468) 1 NC_012987.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor; Putative IcmK-like type IV secretion system protein precursor 133468 8190499 p1METDI0130 Methylobacterium extorquens DM4 Putative IcmK-like type IV secretion system protein precursor YP_003065737.1 132293 R 661410 CDS YP_003065738.1 254558213 8190500 complement(133465..134121) 1 NC_012987.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 134121 8190500 p1METDI0131 Methylobacterium extorquens DM4 hypothetical protein YP_003065738.1 133465 R 661410 CDS YP_003065739.1 254558214 8190501 complement(134118..134393) 1 NC_012987.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 134393 8190501 p1METDI0132 Methylobacterium extorquens DM4 hypothetical protein YP_003065739.1 134118 R 661410 CDS YP_003065740.1 254558215 8190502 complement(134395..134979) 1 NC_012987.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 134979 8190502 p1METDI0133 Methylobacterium extorquens DM4 hypothetical protein YP_003065740.1 134395 R 661410 CDS YP_003065741.1 254558216 8190503 135814..136305 1 NC_012987.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 136305 8190503 p1METDI0134 Methylobacterium extorquens DM4 hypothetical protein YP_003065741.1 135814 D 661410 CDS YP_003065742.1 254558217 8190504 complement(136322..136852) 1 NC_012987.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 136852 8190504 p1METDI0135 Methylobacterium extorquens DM4 hypothetical protein YP_003065742.1 136322 R 661410 CDS YP_003065743.1 254558218 8190505 137087..138286 1 NC_012987.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 138286 8190505 p1METDI0136 Methylobacterium extorquens DM4 hypothetical protein YP_003065743.1 137087 D 661410 CDS YP_003065744.1 254558219 8190506 138290..139471 1 NC_012987.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative Type II/IV secretion system protein (ATPase) 139471 8190506 p1METDI0137 Methylobacterium extorquens DM4 putative Type II/IV secretion system protein (ATPase) YP_003065744.1 138290 D 661410 CDS YP_003065745.1 254558220 8190507 139440..140090 1 NC_012987.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 140090 8190507 p1METDI0138 Methylobacterium extorquens DM4 hypothetical protein YP_003065745.1 139440 D 661410 CDS YP_003065746.1 254558221 8190508 140123..140332 1 NC_012987.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 140332 8190508 p1METDI0139 Methylobacterium extorquens DM4 hypothetical protein YP_003065746.1 140123 D 661410 CDS YP_003065747.1 254558222 8190509 140317..140994 1 NC_012987.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 140994 8190509 p1METDI0140 Methylobacterium extorquens DM4 hypothetical protein YP_003065747.1 140317 D 661410 CDS YP_003065748.1 254558223 8190510 141009..141389 1 NC_012987.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 141389 8190510 p1METDI0141 Methylobacterium extorquens DM4 hypothetical protein YP_003065748.1 141009 D 661410 CDS YP_003065749.1 254558654 8196384 710..2215 1 NC_012988.1 binds to the dnaA-box as an ATP-bound complex at the origin of replication during the initiation of chromosomal replication; can also affect transcription of multiple genes including itself.; chromosomal replication initiation protein 2215 dnaA 8196384 dnaA Methylobacterium extorquens DM4 chromosomal replication initiation protein YP_003065749.1 710 D 661410 CDS YP_003065750.1 254558655 8195301 2535..3656 1 NC_012988.1 binds the polymerase to DNA and acts as a sliding clamp; DNA polymerase III subunit beta 3656 dnaN 8195301 dnaN Methylobacterium extorquens DM4 DNA polymerase III subunit beta YP_003065750.1 2535 D 661410 CDS YP_003065751.1 254558656 8195309 3697..4851 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type cp : cell process; putative RecF protein 4851 recF 8195309 recF Methylobacterium extorquens DM4 putative RecF protein YP_003065751.1 3697 D 661410 CDS YP_003065752.1 254558657 8195969 complement(4855..5259) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5259 8195969 METDI0004 Methylobacterium extorquens DM4 hypothetical protein YP_003065752.1 4855 R 661410 CDS YP_003065753.1 254558658 8190538 complement(5259..5498) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5498 8190538 METDI0005 Methylobacterium extorquens DM4 hypothetical protein YP_003065753.1 5259 R 661410 CDS YP_003065754.1 254558659 8190539 5601..7448 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 3027506; Product type e : enzyme; ATP-dependent DNA helicase 7448 recQ 8190539 recQ Methylobacterium extorquens DM4 ATP-dependent DNA helicase YP_003065754.1 5601 D 661410 CDS YP_003065755.1 254558660 8195974 complement(7506..7784) 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 7784 8195974 METDI0007 Methylobacterium extorquens DM4 hypothetical protein YP_003065755.1 7506 R 661410 CDS YP_003065756.1 254558661 8190540 8160..8846 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 8846 8190540 METDI0008 Methylobacterium extorquens DM4 hypothetical protein YP_003065756.1 8160 D 661410 CDS YP_003065757.1 254558662 8190541 8968..11169 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; Helicase 11169 recD 8190541 recD Methylobacterium extorquens DM4 Helicase YP_003065757.1 8968 D 661410 CDS YP_003065758.1 254558663 8195968 11313..12497 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 12497 8195968 METDI0010 Methylobacterium extorquens DM4 hypothetical protein YP_003065758.1 11313 D 661410 CDS YP_003065759.1 254558664 8190542 12688..14913 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 1398079, 8828210; Product type e : enzyme; phosphoribosylformylglycinamide synthetase 14913 purL 8190542 purL Methylobacterium extorquens DM4 phosphoribosylformylglycinamide synthetase YP_003065759.1 12688 D 661410 CDS YP_003065760.1 254558665 8195937 14941..15177 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; BolA-like protein 15177 8195937 METDI0012 Methylobacterium extorquens DM4 BolA-like protein YP_003065760.1 14941 D 661410 CDS YP_003065761.1 254558666 8190543 15251..15586 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type f : factor; glutaredoxin-like protein 15586 8190543 METDI0013 Methylobacterium extorquens DM4 glutaredoxin-like protein YP_003065761.1 15251 D 661410 CDS YP_003065762.1 254558667 8190544 15659..16561 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type e : enzyme; putative FAD-dependent pyridine nucleotide-disulphide oxidoreductase 16561 8190544 METDI0014 Methylobacterium extorquens DM4 putative FAD-dependent pyridine nucleotide-disulphide oxidoreductase YP_003065762.1 15659 D 661410 CDS YP_003065763.1 254558668 8190545 16670..17554 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 17554 8190545 METDI0015 Methylobacterium extorquens DM4 hypothetical protein YP_003065763.1 16670 D 661410 CDS YP_003065764.1 254558669 8190546 complement(17983..18816) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 18816 8190546 METDI0017 Methylobacterium extorquens DM4 hypothetical protein YP_003065764.1 17983 R 661410 CDS YP_003065765.1 254558670 8190547 complement(19186..21231) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative sensor hybrid histidine kinase with PAS/PAC motif and response regulator receiver domains 21231 8190547 METDI0018 Methylobacterium extorquens DM4 putative sensor hybrid histidine kinase with PAS/PAC motif and response regulator receiver domains YP_003065765.1 19186 R 661410 CDS YP_003065766.1 254558671 8190548 complement(21231..22757) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 22757 8190548 METDI0019 Methylobacterium extorquens DM4 hypothetical protein YP_003065766.1 21231 R 661410 CDS YP_003065767.1 254558672 8190549 23143..24348 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 24348 8190549 METDI0020 Methylobacterium extorquens DM4 hypothetical protein YP_003065767.1 23143 D 661410 CDS YP_003065768.1 254558673 8190550 complement(24379..25377) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative Short-chain dehydrogenase/reductase SDR 25377 8190550 METDI0021 Methylobacterium extorquens DM4 putative Short-chain dehydrogenase/reductase SDR YP_003065768.1 24379 R 661410 CDS YP_003065769.1 254558674 8190551 complement(25500..26186) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type r : regulator; transcriptional regulator, GntR family 26186 8190551 METDI0022 Methylobacterium extorquens DM4 transcriptional regulator, GntR family YP_003065769.1 25500 R 661410 CDS YP_003065770.1 254558675 8190553 26832..28478 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; malonate decarboxylase, alpha subunit 28478 mdcA 8190553 mdcA Methylobacterium extorquens DM4 malonate decarboxylase, alpha subunit YP_003065770.1 26832 D 661410 CDS YP_003065771.1 254558676 8195670 28486..28794 1 NC_012988.1 acyl carrier protein of malonate decarboxylase; malonate decarboxylase subunit delta 28794 mdcC 8195670 mdcC Methylobacterium extorquens DM4 malonate decarboxylase subunit delta YP_003065771.1 28486 D 661410 CDS YP_003065772.1 254558677 8195672 28797..29729 1 NC_012988.1 The beta subunit catalyzes the decarboxylation of the malonyl moiety on coenzyme A; malonate decarboxylase subunit beta 29729 mdcD 8195672 mdcD Methylobacterium extorquens DM4 malonate decarboxylase subunit beta YP_003065772.1 28797 D 661410 CDS YP_003065773.1 254558678 8195673 29716..30432 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; Malonate decarboxylase, gamma subunit 30432 mdcE 8195673 mdcE Methylobacterium extorquens DM4 Malonate decarboxylase, gamma subunit YP_003065773.1 29716 D 661410 CDS YP_003065774.1 254558679 8195674 30425..31084 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; phosphoribosyl-dephospho-CoA transferase 31084 8195674 METDI0028 Methylobacterium extorquens DM4 phosphoribosyl-dephospho-CoA transferase YP_003065774.1 30425 D 661410 CDS YP_003065775.1 254558680 8190554 31081..31938 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; 2'-(5''-triphosphoribosyl)-3'-dephosphocoenzyme- A synthase 31938 mdcB 8190554 mdcB Methylobacterium extorquens DM4 2'-(5''-triphosphoribosyl)-3'-dephosphocoenzyme- A synthase YP_003065775.1 31081 D 661410 CDS YP_003065776.1 254558681 8195671 31935..32858 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 9642179; Product type e : enzyme; Acyl transferase domain protein, putative malonyl CoA-acyl carrier protein transacylase (MCT, fabD-like) 32858 8195671 METDI0030 Methylobacterium extorquens DM4 Acyl transferase domain protein, putative malonyl CoA-acyl carrier protein transacylase (MCT, fabD-like) YP_003065776.1 31935 D 661410 CDS YP_003065777.1 254558682 8190555 complement(32996..35380) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type t : transporter; putative General secretion pathway protein D 35380 8190555 METDI0031 Methylobacterium extorquens DM4 putative General secretion pathway protein D YP_003065777.1 32996 R 661410 CDS YP_003065778.1 254558683 8190556 complement(35472..36341) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor; putative general secretory pathway protein 36341 8190556 METDI0032 Methylobacterium extorquens DM4 putative general secretory pathway protein YP_003065778.1 35472 R 661410 CDS YP_003065779.1 254558684 8190557 complement(36356..36967) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 1944223, 2129543; Product type m : membrane component; putative general secretion pathway protein 36967 8190557 METDI0033 Methylobacterium extorquens DM4 putative general secretion pathway protein YP_003065779.1 36356 R 661410 CDS YP_003065780.1 254558685 8190558 complement(36960..37355) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative general secretion pathway protein 37355 8190558 METDI0034 Methylobacterium extorquens DM4 putative general secretion pathway protein YP_003065780.1 36960 R 661410 CDS YP_003065781.1 254558686 8190559 complement(37352..37825) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative general secretion pathway protein 37825 8190559 METDI0035 Methylobacterium extorquens DM4 putative general secretion pathway protein YP_003065781.1 37352 R 661410 CDS YP_003065782.1 254558687 8190560 37946..38257 1 NC_012988.1 Evidence 6 : Doubtful CDS; Product type e : enzyme; hypothetical protein 38257 8190560 METDI0036 Methylobacterium extorquens DM4 hypothetical protein YP_003065782.1 37946 D 661410 CDS YP_003065783.1 254558688 8190561 38421..38633 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 38633 8190561 METDI0037 Methylobacterium extorquens DM4 hypothetical protein YP_003065783.1 38421 D 661410 CDS YP_003065784.1 254558689 8190562 complement(38830..39207) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 39207 8190562 METDI0038 Methylobacterium extorquens DM4 hypothetical protein YP_003065784.1 38830 R 661410 CDS YP_003065785.1 254558690 8190563 40276..40584 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 40584 8190563 METDI0039 Methylobacterium extorquens DM4 hypothetical protein YP_003065785.1 40276 D 661410 CDS YP_003065786.1 254558691 8190564 40718..41089 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 41089 8190564 METDI0040 Methylobacterium extorquens DM4 hypothetical protein YP_003065786.1 40718 D 661410 CDS YP_003065787.1 254558692 8190565 42149..42574 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; transposase of ISMex15, IS5 family (ORF 1) 42574 8190565 METDI0041 Methylobacterium extorquens DM4 transposase of ISMex15, IS5 family (ORF 1) YP_003065787.1 42149 D 661410 CDS YP_003065788.1 254558693 8190566 42349..42903 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; transposase of ISMex15, IS5 family (ORF 2) 42903 8190566 METDI0042 Methylobacterium extorquens DM4 transposase of ISMex15, IS5 family (ORF 2) YP_003065788.1 42349 D 661410 CDS YP_003065789.1 254558694 8190567 43148..43609 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 43609 8190567 METDI0043 Methylobacterium extorquens DM4 hypothetical protein YP_003065789.1 43148 D 661410 CDS YP_003065790.1 254558695 8190568 43940..44143 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 44143 8190568 METDI0045 Methylobacterium extorquens DM4 hypothetical protein YP_003065790.1 43940 D 661410 CDS YP_003065791.1 254558696 8190569 45341..45859 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative integrase/resolvase recombinase 45859 8190569 METDI0046 Methylobacterium extorquens DM4 putative integrase/resolvase recombinase YP_003065791.1 45341 D 661410 CDS YP_003065792.1 254558697 8190570 complement(46637..46999) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 46999 8190570 METDI0047 Methylobacterium extorquens DM4 hypothetical protein YP_003065792.1 46637 R 661410 CDS YP_003065793.1 254558698 8190571 complement(48233..48526) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 48526 8190571 METDI0048 Methylobacterium extorquens DM4 hypothetical protein YP_003065793.1 48233 R 661410 CDS YP_003065794.1 254558699 8190572 complement(48529..49293) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type pr : putative regulator; Regulatory protein, Crp (cAMP Receptor Protein) 49293 8190572 METDI0049 Methylobacterium extorquens DM4 Regulatory protein, Crp (cAMP Receptor Protein) YP_003065794.1 48529 R 661410 CDS YP_003065795.1 254558700 8190573 49566..50198 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcriptional regulator, Crp/Fnr family, with N-terminal cNMP-binding domain 50198 8190573 METDI0050 Methylobacterium extorquens DM4 putative transcriptional regulator, Crp/Fnr family, with N-terminal cNMP-binding domain YP_003065795.1 49566 D 661410 CDS YP_003065796.1 254558701 8190574 complement(50602..50811) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 50811 8190574 METDI0051 Methylobacterium extorquens DM4 hypothetical protein YP_003065796.1 50602 R 661410 CDS YP_003065797.1 254558702 8190575 complement(50850..51383) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 51383 8190575 METDI0052 Methylobacterium extorquens DM4 hypothetical protein YP_003065797.1 50850 R 661410 CDS YP_003065798.1 254558703 8190576 complement(51430..52740) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative site-specific recombinase 52740 8190576 METDI0053 Methylobacterium extorquens DM4 putative site-specific recombinase YP_003065798.1 51430 R 661410 CDS YP_003065799.1 254558704 8196250 complement(53123..54364) 1 NC_012988.1 catalyzes the formation of L-tryptophan from L-serine and 1-(indol-3-yl)glycerol 3-phosphate; tryptophan synthase subunit beta 54364 trpB 8196250 trpB Methylobacterium extorquens DM4 tryptophan synthase subunit beta YP_003065799.1 53123 R 661410 CDS YP_003065800.1 254558705 8196273 complement(54487..55134) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10360571, 9166771; Product type pe : putative enzyme; putative phosphoribosylanthranilate isomerase 55134 trpF 8196273 trpF Methylobacterium extorquens DM4 putative phosphoribosylanthranilate isomerase YP_003065800.1 54487 R 661410 CDS YP_003065801.1 254558706 8196277 complement(55158..55526) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 55526 8196277 METDI0056 Methylobacterium extorquens DM4 hypothetical protein YP_003065801.1 55158 R 661410 CDS YP_003065802.1 254558707 8190578 complement(55752..56060) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 8407826, 92021785, 92155171, 93078609; Product type h : extrachromosomal origin; integration host factor (IHF), beta subunit, site-specific recombination 56060 ihfB 8190578 ihfB Methylobacterium extorquens DM4 integration host factor (IHF), beta subunit, site-specific recombination YP_003065802.1 55752 R 661410 CDS YP_003065803.1 254558708 8195590 complement(56102..57067) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; putative peptidase 57067 sppA 8195590 sppA Methylobacterium extorquens DM4 putative peptidase YP_003065803.1 56102 R 661410 CDS YP_003065804.1 254558709 8196144 complement(57328..58653) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; hypothetical protein 58653 8196144 METDI0059 Methylobacterium extorquens DM4 hypothetical protein YP_003065804.1 57328 R 661410 CDS YP_003065805.1 254558710 8190579 complement(58746..60458) 1 NC_012988.1 in Escherichia coli this protein is involved in binding to the leader sequence of mRNAs and is itself bound to the 30S subunit; autoregulates expression via a C-terminal domain; in most gram negative organisms this protein is composed of 6 repeats of the S1 domain while in gram positive there are 4 repeats; the S1 nucleic acid-binding domain is found associated with other proteins; 30S ribosomal protein S1 60458 rpsA 8190579 rpsA Methylobacterium extorquens DM4 30S ribosomal protein S1 YP_003065805.1 58746 R 661410 CDS YP_003065806.1 254558711 8196052 complement(60873..61679) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; rRNA methylase 61679 rrm1 8196052 rrm1 Methylobacterium extorquens DM4 rRNA methylase YP_003065806.1 60873 R 661410 CDS YP_003065807.1 254558712 8196223 complement(62331..62798) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 62798 8196223 METDI0063 Methylobacterium extorquens DM4 hypothetical protein YP_003065807.1 62331 R 661410 CDS YP_003065808.1 254558713 8190580 63245..64183 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type f : factor; Pirin-like protein 64183 8190580 METDI0066 Methylobacterium extorquens DM4 Pirin-like protein YP_003065808.1 63245 D 661410 CDS YP_003065809.1 254558714 8190581 64286..66052 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type t : transporter; potassium:proton antiporter (CPA2 family) 66052 kefB 8190581 kefB Methylobacterium extorquens DM4 potassium:proton antiporter (CPA2 family) YP_003065809.1 64286 D 661410 CDS YP_003065810.1 254558715 8195622 66232..66951 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; putative cytochrome biogenesis protein 66951 8195622 METDI0068 Methylobacterium extorquens DM4 putative cytochrome biogenesis protein YP_003065810.1 66232 D 661410 CDS YP_003065811.1 254558716 8190582 67059..67673 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type e : enzyme; putative 3-methyladenine DNA glycosylase 67673 8190582 METDI0069 Methylobacterium extorquens DM4 putative 3-methyladenine DNA glycosylase YP_003065811.1 67059 D 661410 CDS YP_003065812.1 254558717 8190583 complement(67679..67936) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 67936 8190583 METDI0070 Methylobacterium extorquens DM4 hypothetical protein YP_003065812.1 67679 R 661410 CDS YP_003065813.1 254558718 8190584 68264..68482 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 68482 8190584 METDI0071 Methylobacterium extorquens DM4 hypothetical protein YP_003065813.1 68264 D 661410 CDS YP_003065814.1 254558719 8190585 complement(68597..70294) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type cp : cell process; Methyl-accepting chemotaxis receptor/sensory transducer 70294 8190585 METDI0072 Methylobacterium extorquens DM4 Methyl-accepting chemotaxis receptor/sensory transducer YP_003065814.1 68597 R 661410 CDS YP_003065815.1 254558720 8190586 70677..72299 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative ATP-binding protein with two ATPase domains, ABC transporter related 72299 8190586 METDI0073 Methylobacterium extorquens DM4 putative ATP-binding protein with two ATPase domains, ABC transporter related YP_003065815.1 70677 D 661410 CDS YP_003065816.1 254558721 8190587 complement(72307..72663) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 72663 8190587 METDI0074 Methylobacterium extorquens DM4 hypothetical protein YP_003065816.1 72307 R 661410 CDS YP_003065817.1 254558722 8190588 complement(72673..72912) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 72912 8190588 METDI0075 Methylobacterium extorquens DM4 hypothetical protein YP_003065817.1 72673 R 661410 CDS YP_003065818.1 254558723 8190589 complement(73127..73771) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 73771 8190589 METDI0076 Methylobacterium extorquens DM4 hypothetical protein YP_003065818.1 73127 R 661410 CDS YP_003065819.1 254558724 8190590 complement(73782..74417) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 8121412; hypothetical protein 74417 8190590 METDI0077 Methylobacterium extorquens DM4 hypothetical protein YP_003065819.1 73782 R 661410 CDS YP_003065820.1 254558725 8190591 74524..75507 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 75507 8190591 METDI0078 Methylobacterium extorquens DM4 hypothetical protein YP_003065820.1 74524 D 661410 CDS YP_003065821.1 254558726 8190592 complement(75528..76712) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8631780; Product type pe : putative enzyme; putative glycosyl transferase 76712 8190592 METDI0079 Methylobacterium extorquens DM4 putative glycosyl transferase YP_003065821.1 75528 R 661410 CDS YP_003065822.1 254558727 8190593 complement(76712..77752) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11583114; Product type pe : putative enzyme; putative glycosyl transferase 77752 8190593 METDI0080 Methylobacterium extorquens DM4 putative glycosyl transferase YP_003065822.1 76712 R 661410 CDS YP_003065823.1 254558728 8190594 77810..79864 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 79864 8190594 METDI0081 Methylobacterium extorquens DM4 hypothetical protein YP_003065823.1 77810 D 661410 CDS YP_003065824.1 254558729 8190595 79886..80776 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15294902; Product type pe : putative enzyme; putative glycosyl transferase 80776 8190595 METDI0082 Methylobacterium extorquens DM4 putative glycosyl transferase YP_003065824.1 79886 D 661410 CDS YP_003065825.1 254558730 8190596 80825..81973 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative glycosyl transferase; putative UDP-N-acetylglucosamine, LPS N-acetylglucosamine transferase 81973 8190596 METDI0083 Methylobacterium extorquens DM4 putative glycosyl transferase; putative UDP-N-acetylglucosamine, LPS N-acetylglucosamine transferase YP_003065825.1 80825 D 661410 CDS YP_003065826.1 254558731 8190597 82024..82965 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 82965 8190597 METDI0084 Methylobacterium extorquens DM4 hypothetical protein YP_003065826.1 82024 D 661410 CDS YP_003065827.1 254558732 8190598 82962..84017 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12068013; Product type pe : putative enzyme; putative glycosyl transferase 84017 8190598 METDI0085 Methylobacterium extorquens DM4 putative glycosyl transferase YP_003065827.1 82962 D 661410 CDS YP_003065828.1 254558733 8190599 84063..84731 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 14523113, 9791104; Product type pe : putative enzyme; putative methyltransferase, putative O-methyltransferase 84731 8190599 METDI0086 Methylobacterium extorquens DM4 putative methyltransferase, putative O-methyltransferase YP_003065828.1 84063 D 661410 CDS YP_003065829.1 254558734 8190600 85417..86526 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative metal dependent phosphohydrolase with a response regulator receiver domain; HD-GYP domain protein 86526 8190600 METDI0087 Methylobacterium extorquens DM4 putative metal dependent phosphohydrolase with a response regulator receiver domain; HD-GYP domain protein YP_003065829.1 85417 D 661410 CDS YP_003065830.1 254558735 8190601 86691..89387 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; Excinuclease ABC, A subunit 89387 8190601 METDI0088 Methylobacterium extorquens DM4 Excinuclease ABC, A subunit YP_003065830.1 86691 D 661410 CDS YP_003065831.1 254558736 8190602 complement(89429..90385) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11481431; Product type pe : putative enzyme; putative transcriptional regulator, AraC family 90385 8190602 METDI0089 Methylobacterium extorquens DM4 putative transcriptional regulator, AraC family YP_003065831.1 89429 R 661410 CDS YP_003065832.1 254558737 8190603 90513..91301 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; Short-chain dehydrogenase/reductase SDR 91301 8190603 METDI0090 Methylobacterium extorquens DM4 Short-chain dehydrogenase/reductase SDR YP_003065832.1 90513 D 661410 CDS YP_003065833.1 254558738 8190604 91494..91940 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 7782304, 8157655; Product type e : enzyme; isoquinoline 1-oxidoreductase, alpha subunit 91940 iorA 8190604 iorA Methylobacterium extorquens DM4 isoquinoline 1-oxidoreductase, alpha subunit YP_003065833.1 91494 D 661410 CDS YP_003065834.1 254558739 8195603 91951..94209 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; isoquinoline 1-oxidoreductase, beta subunit 94209 iorB 8195603 iorB Methylobacterium extorquens DM4 isoquinoline 1-oxidoreductase, beta subunit YP_003065834.1 91951 D 661410 CDS YP_003065835.1 254558740 8195604 94220..95227 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative potassium-tellurite ethidium and proflavin transporter 95227 8195604 METDI0093 Methylobacterium extorquens DM4 putative potassium-tellurite ethidium and proflavin transporter YP_003065835.1 94220 D 661410 CDS YP_003065836.1 254558741 8190605 95459..96709 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 7719856; Product type e : enzyme; D-3-phosphoglycerate dehydrogenase 96709 serA 8190605 serA Methylobacterium extorquens DM4 D-3-phosphoglycerate dehydrogenase YP_003065836.1 95459 D 661410 CDS YP_003065837.1 254558742 8196109 96725..98122 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative D-lactate dehydrogenase (cytochrome) 98122 8196109 METDI0095 Methylobacterium extorquens DM4 putative D-lactate dehydrogenase (cytochrome) YP_003065837.1 96725 D 661410 CDS YP_003065838.1 254558743 8190606 98856..99515 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier; putative nitrite reductase, formate-dependent, penta-heme cytochrome c 99515 8190606 METDI0096 Methylobacterium extorquens DM4 putative nitrite reductase, formate-dependent, penta-heme cytochrome c YP_003065838.1 98856 D 661410 CDS YP_003065839.1 254558744 8190607 99503..102313 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier; putative 4Fe-4S ferredoxin, iron-sulfur binding 102313 8190607 METDI0097 Methylobacterium extorquens DM4 putative 4Fe-4S ferredoxin, iron-sulfur binding YP_003065839.1 99503 D 661410 CDS YP_003065840.1 254558745 8190608 102310..103680 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; Polysulphide reductase, NrfD 103680 8190608 METDI0098 Methylobacterium extorquens DM4 Polysulphide reductase, NrfD YP_003065840.1 102310 D 661410 CDS YP_003065841.1 254558746 8190609 103677..104195 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 104195 8190609 METDI0099 Methylobacterium extorquens DM4 hypothetical protein YP_003065841.1 103677 D 661410 CDS YP_003065842.1 254558747 8190610 104192..104719 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier; putative cytochrome c family protein 104719 8190610 METDI0100 Methylobacterium extorquens DM4 putative cytochrome c family protein YP_003065842.1 104192 D 661410 CDS YP_003065843.1 254558748 8190611 104716..105672 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 105672 8190611 METDI0101 Methylobacterium extorquens DM4 hypothetical protein YP_003065843.1 104716 D 661410 CDS YP_003065844.1 254558749 8190612 105647..106186 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 106186 8190612 METDI0102 Methylobacterium extorquens DM4 hypothetical protein YP_003065844.1 105647 D 661410 CDS YP_003065845.1 254558750 8190613 106186..107274 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative Cytochrome c oxidase, subunit II (coxB-like) 107274 8190613 METDI0103 Methylobacterium extorquens DM4 putative Cytochrome c oxidase, subunit II (coxB-like) YP_003065845.1 106186 D 661410 CDS YP_003065846.1 254558751 8190614 107306..108997 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; cytochrome c oxidase subunit I 108997 coxA 8190614 coxA Methylobacterium extorquens DM4 cytochrome c oxidase subunit I YP_003065846.1 107306 D 661410 CDS YP_003065847.1 254558752 8195204 108994..109683 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative Cytochrome c oxidase, subunit III 109683 8195204 METDI0105 Methylobacterium extorquens DM4 putative Cytochrome c oxidase, subunit III YP_003065847.1 108994 D 661410 CDS YP_003065848.1 254558753 8190615 109680..109982 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative cytochrome oxidase subunit IV 109982 8190615 METDI0106 Methylobacterium extorquens DM4 putative cytochrome oxidase subunit IV YP_003065848.1 109680 D 661410 CDS YP_003065849.1 254558754 8190617 complement(110498..110782) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 110782 8190617 METDI0108 Methylobacterium extorquens DM4 hypothetical protein YP_003065849.1 110498 R 661410 CDS YP_003065850.1 254558755 8190618 111049..111579 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type f : factor; RNA polymerase sigma factor 111579 8190618 METDI0109 Methylobacterium extorquens DM4 RNA polymerase sigma factor YP_003065850.1 111049 D 661410 CDS YP_003065851.1 254558756 8190619 111582..112349 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 112349 8190619 METDI0110 Methylobacterium extorquens DM4 hypothetical protein YP_003065851.1 111582 D 661410 CDS YP_003065852.1 254558757 8190620 112357..113469 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative catalase 113469 8190620 METDI0111 Methylobacterium extorquens DM4 putative catalase YP_003065852.1 112357 D 661410 CDS YP_003065853.1 254558758 8190621 113466..114032 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type c : carrier; Cytochrome B561 114032 8190621 METDI0112 Methylobacterium extorquens DM4 Cytochrome B561 YP_003065853.1 113466 D 661410 CDS YP_003065854.1 254558759 8190622 complement(113991..114251) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 114251 8190622 METDI0113 Methylobacterium extorquens DM4 hypothetical protein YP_003065854.1 113991 R 661410 CDS YP_003065855.1 254558760 8190623 114518..114607 1 NC_012988.1 one of the components of the high-affinity ATP-driven potassium transport (or KDP)system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions; potassium-transporting ATPase subunit F 114607 8190623 METDI0115 Methylobacterium extorquens DM4 potassium-transporting ATPase subunit F YP_003065855.1 114518 D 661410 CDS YP_003065856.1 254558761 8190624 114629..116344 1 NC_012988.1 catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions; potassium-transporting ATPase subunit A 116344 kdpA 8190624 kdpA Methylobacterium extorquens DM4 potassium-transporting ATPase subunit A YP_003065856.1 114629 D 661410 CDS YP_003065857.1 254558762 8195614 116373..116534 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 116534 8195614 METDI0117 Methylobacterium extorquens DM4 hypothetical protein YP_003065857.1 116373 D 661410 CDS YP_003065858.1 254558763 8190625 116594..118684 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 6146979, 92202140, 93167625, 9858692; Product type t : transporter; Potassium-transporting ATPase B chain (Potassium-translocating ATPase B chain) (ATP phosphohydrolase [potassium-transporting] B chain) (Potassium binding and translocating subunit B) 118684 kdpB 8190625 kdpB Methylobacterium extorquens DM4 Potassium-transporting ATPase B chain (Potassium-translocating ATPase B chain) (ATP phosphohydrolase [potassium-transporting] B chain) (Potassium binding and translocating subunit B) YP_003065858.1 116594 D 661410 CDS YP_003065859.1 254558764 8195615 118708..119313 1 NC_012988.1 one of the components of the high-affinity ATP-driven potassium transport (or KDP)system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions; the C subunit may be involved in assembly of the KDP complex; potassium-transporting ATPase subunit C 119313 kdpC 8195615 kdpC Methylobacterium extorquens DM4 potassium-transporting ATPase subunit C YP_003065859.1 118708 D 661410 CDS YP_003065860.1 254558765 8195616 119324..122041 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; sensory histidine kinase 122041 kdpD 8195616 kdpD Methylobacterium extorquens DM4 sensory histidine kinase YP_003065860.1 119324 D 661410 CDS YP_003065861.1 254558766 8195617 122038..122784 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type r : regulator; response regulator in two-component regulatory system with KdpD, regulation of potassium translocation (OmpR family) 122784 kdpE 8195617 kdpE Methylobacterium extorquens DM4 response regulator in two-component regulatory system with KdpD, regulation of potassium translocation (OmpR family) YP_003065861.1 122038 D 661410 CDS YP_003065862.1 254558767 8195618 complement(123034..123267) 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 123267 8195618 METDI0122 Methylobacterium extorquens DM4 hypothetical protein YP_003065862.1 123034 R 661410 CDS YP_003065863.1 254558768 8190626 123528..124838 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 124838 8190626 METDI0123 Methylobacterium extorquens DM4 hypothetical protein YP_003065863.1 123528 D 661410 CDS YP_003065864.1 254558769 8190628 complement(125145..126083) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 126083 8190628 METDI0125 Methylobacterium extorquens DM4 hypothetical protein YP_003065864.1 125145 R 661410 CDS YP_003065865.1 254558770 8190629 complement(126080..126868) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 126868 8190629 METDI0126 Methylobacterium extorquens DM4 hypothetical protein YP_003065865.1 126080 R 661410 CDS YP_003065866.1 254558771 8190630 complement(126865..127650) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 127650 8190630 METDI0127 Methylobacterium extorquens DM4 hypothetical protein YP_003065866.1 126865 R 661410 CDS YP_003065867.1 254558772 8190631 complement(127647..128744) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; Myo-inositol-1-phosphate synthase 128744 8190631 METDI0128 Methylobacterium extorquens DM4 Myo-inositol-1-phosphate synthase YP_003065867.1 127647 R 661410 CDS YP_003065868.1 254558773 8190632 complement(128744..129784) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative dTDP-glucose 4,6-dehydratase 129784 8190632 METDI0129 Methylobacterium extorquens DM4 putative dTDP-glucose 4,6-dehydratase YP_003065868.1 128744 R 661410 CDS YP_003065869.1 254558774 8190633 complement(129796..130911) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 130911 8190633 METDI0130 Methylobacterium extorquens DM4 hypothetical protein YP_003065869.1 129796 R 661410 CDS YP_003065870.1 254558775 8190634 complement(130908..132014) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 132014 8190634 METDI0131 Methylobacterium extorquens DM4 hypothetical protein YP_003065870.1 130908 R 661410 CDS YP_003065871.1 254558776 8190635 complement(132011..133138) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 133138 8190635 METDI0132 Methylobacterium extorquens DM4 hypothetical protein YP_003065871.1 132011 R 661410 CDS YP_003065872.1 254558777 8190636 complement(133135..134241) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12068013; Product type pe : putative enzyme; putative glycosyl transferase 134241 8190636 METDI0133 Methylobacterium extorquens DM4 putative glycosyl transferase YP_003065872.1 133135 R 661410 CDS YP_003065873.1 254558778 8190637 complement(134232..135527) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; Radical SAM domain protein 135527 8190637 METDI0134 Methylobacterium extorquens DM4 Radical SAM domain protein YP_003065873.1 134232 R 661410 CDS YP_003065874.1 254558779 8190638 complement(135524..136615) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative dTDP-glucose 4,6-dehydratase 136615 8190638 METDI0135 Methylobacterium extorquens DM4 putative dTDP-glucose 4,6-dehydratase YP_003065874.1 135524 R 661410 CDS YP_003065875.1 254558780 8190639 complement(136612..137724) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative UDP-glucose 4-epimerase 137724 8190639 METDI0136 Methylobacterium extorquens DM4 putative UDP-glucose 4-epimerase YP_003065875.1 136612 R 661410 CDS YP_003065876.1 254558781 8190640 137916..138104 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 138104 8190640 METDI0137 Methylobacterium extorquens DM4 hypothetical protein YP_003065876.1 137916 D 661410 CDS YP_003065877.1 254558782 8190641 complement(138526..138993) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 138993 8190641 METDI0138 Methylobacterium extorquens DM4 hypothetical protein YP_003065877.1 138526 R 661410 CDS YP_003065878.1 254558783 8190642 139254..139535 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; transposase of ISMdi3, IS3 family (ORF 1) 139535 8190642 METDI0139 Methylobacterium extorquens DM4 transposase of ISMdi3, IS3 family (ORF 1) YP_003065878.1 139254 D 661410 CDS YP_003065879.1 254558784 8190643 139643..140395 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; transposase of ISMdi3, IS3 family (ORF 2) 140395 8190643 METDI0140 Methylobacterium extorquens DM4 transposase of ISMdi3, IS3 family (ORF 2) YP_003065879.1 139643 D 661410 CDS YP_003065880.1 254558785 8190644 140581..141510 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; transposase of ISMex17, IS110 family 141510 8190644 METDI0141 Methylobacterium extorquens DM4 transposase of ISMex17, IS110 family YP_003065880.1 140581 D 661410 CDS YP_003065881.1 254558786 8190645 141912..142367 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type e : enzyme; component of DNA polymerase V, subunit D 142367 umuD 8190645 umuD Methylobacterium extorquens DM4 component of DNA polymerase V, subunit D YP_003065881.1 141912 D 661410 CDS YP_003065882.1 254558787 8196301 142364..143515 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type e : enzyme; component of DNA polymerase V, subunit C 143515 umuC 8196301 umuC Methylobacterium extorquens DM4 component of DNA polymerase V, subunit C YP_003065882.1 142364 D 661410 CDS YP_003065883.1 254558788 8196299 complement(145410..145631) 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 145631 8196299 METDI0147 Methylobacterium extorquens DM4 hypothetical protein YP_003065883.1 145410 R 661410 CDS YP_003065884.1 254558789 8196263 146255..147568 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type cp : cell process; recombination factor protein RarA 147568 rarA 8196263 rarA Methylobacterium extorquens DM4 recombination factor protein RarA YP_003065884.1 146255 D 661410 CDS YP_003065885.1 254558790 8195964 147565..149097 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative Zn dependent carboxypeptidase 149097 8195964 METDI0149 Methylobacterium extorquens DM4 putative Zn dependent carboxypeptidase YP_003065885.1 147565 D 661410 CDS YP_003065886.1 254558791 8190647 149260..150507 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type f : factor; molecular chaperone, HSP70 class 150507 8190647 METDI0150 Methylobacterium extorquens DM4 molecular chaperone, HSP70 class YP_003065886.1 149260 D 661410 CDS YP_003065887.1 254558792 8190648 150735..152141 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 14704707; Product type e : enzyme; pseudouridylate synthase 152141 rluC 8190648 rluC Methylobacterium extorquens DM4 pseudouridylate synthase YP_003065887.1 150735 D 661410 CDS YP_003065888.1 254558793 8195999 152750..153475 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative haloacid dehalogenase family hydrolase 153475 8195999 METDI0153 Methylobacterium extorquens DM4 putative haloacid dehalogenase family hydrolase YP_003065888.1 152750 D 661410 CDS YP_003065889.1 254558794 8190649 153536..154339 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 154339 8190649 METDI0154 Methylobacterium extorquens DM4 hypothetical protein YP_003065889.1 153536 D 661410 CDS YP_003065890.1 254558795 8190650 154934..156466 1 NC_012988.1 Evidence 1c : Function experimentally demonstrated in the studied genus; Product type e : enzyme; propionyl-CoA carboxylase beta chain 156466 pccB 8190650 pccB Methylobacterium extorquens DM4 propionyl-CoA carboxylase beta chain YP_003065890.1 154934 D 661410 CDS YP_003065891.1 254558796 8195833 complement(156528..157082) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 157082 8195833 METDI0156 Methylobacterium extorquens DM4 hypothetical protein YP_003065891.1 156528 R 661410 CDS YP_003065892.1 254558797 8196268 157519..158166 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type pr : putative regulator; transcriptional regulator TetR family 158166 8196268 METDI0157 Methylobacterium extorquens DM4 transcriptional regulator TetR family YP_003065892.1 157519 D 661410 CDS YP_003065893.1 254558798 8190652 158200..159219 1 NC_012988.1 catalyzes the formation of (R)-2,3-dihydroxy-3-methylbutanoate from (S)-2-hydroxy-2-methyl-3-oxobutanoate in valine and isoleucine biosynthesis; ketol-acid reductoisomerase 159219 ilvC 8190652 ilvC Methylobacterium extorquens DM4 ketol-acid reductoisomerase YP_003065893.1 158200 D 661410 CDS YP_003065894.1 254558799 8195593 159387..160040 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type e : enzyme; Pyridoxamine 5'-phosphate oxidase-related 160040 8195593 METDI0159 Methylobacterium extorquens DM4 Pyridoxamine 5'-phosphate oxidase-related YP_003065894.1 159387 D 661410 CDS YP_003065895.1 254558800 8190653 160104..160976 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 160976 8190653 METDI0160 Methylobacterium extorquens DM4 hypothetical protein YP_003065895.1 160104 D 661410 CDS YP_003065896.1 254558801 8190654 complement(161049..162347) 1 NC_012988.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12730156, 15687219, 16926146, 17548827, 8704985; Product type e : enzyme; crotonyl-CoA carboxylase/reductase 162347 ccr 8190654 ccr Methylobacterium extorquens DM4 crotonyl-CoA carboxylase/reductase YP_003065896.1 161049 R 661410 CDS YP_003065897.1 254558802 8195157 complement(162528..163997) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 14702393, 8955300; Product type e : enzyme; catalase (hydroperoxidase II) 163997 katA 8195157 katA Methylobacterium extorquens DM4 catalase (hydroperoxidase II) YP_003065897.1 162528 R 661410 CDS YP_003065898.1 254558803 8195612 164364..166430 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 11872727, 17548827, 18819910; Product type e : enzyme; ethylmalonyl-CoA mutase 166430 ecm 8195612 ecm Methylobacterium extorquens DM4 ethylmalonyl-CoA mutase YP_003065898.1 164364 D 661410 CDS YP_003065899.1 254558804 8195324 complement(166540..167226) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 167226 8195324 METDI0164 Methylobacterium extorquens DM4 hypothetical protein YP_003065899.1 166540 R 661410 CDS YP_003065900.1 254558805 8190655 complement(167498..168244) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; Short-chain dehydrogenase/reductase SDR 168244 8190655 METDI0165 Methylobacterium extorquens DM4 Short-chain dehydrogenase/reductase SDR YP_003065900.1 167498 R 661410 CDS YP_003065901.1 254558806 8190656 168353..168682 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcriptional regulator, arsR family 168682 8190656 METDI0166 Methylobacterium extorquens DM4 putative transcriptional regulator, arsR family YP_003065901.1 168353 D 661410 CDS YP_003065902.1 254558807 8190657 168834..169895 1 NC_012988.1 catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; tryptophanyl-tRNA synthetase 169895 trpS 8190657 trpS Methylobacterium extorquens DM4 tryptophanyl-tRNA synthetase YP_003065902.1 168834 D 661410 CDS YP_003065903.1 254558808 8196279 complement(170011..170184) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 170184 8196279 METDI0168 Methylobacterium extorquens DM4 hypothetical protein YP_003065903.1 170011 R 661410 CDS YP_003065904.1 254558809 8190658 170344..170949 1 NC_012988.1 catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate in leucine biosynthesis; forms a heterodimer of LeuC/D; isopropylmalate isomerase small subunit 170949 leuD 8190658 leuD Methylobacterium extorquens DM4 isopropylmalate isomerase small subunit YP_003065904.1 170344 D 661410 CDS YP_003065905.1 254558810 8195631 complement(170957..171598) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative pyrrolidone-carboxylate peptidase 171598 8195631 METDI0170 Methylobacterium extorquens DM4 putative pyrrolidone-carboxylate peptidase YP_003065905.1 170957 R 661410 CDS YP_003065906.1 254558811 8190659 complement(171595..172584) 1 NC_012988.1 functions in transport of arginine/ornithine; inner membrane ATPase that cleaves ATP and phosphorylates two periplasmic proteins that function as two distinct transport systems, the AO (arginine and ornithine) and LAO (lysine, arginine, and ornithine) periplasmic binding proteins; arginine/ornithine transport system ATPase 172584 meaB 8190659 meaB Methylobacterium extorquens DM4 arginine/ornithine transport system ATPase YP_003065906.1 171595 R 661410 CDS YP_003065907.1 254558812 8195677 172731..173765 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 173765 8195677 METDI0172 Methylobacterium extorquens DM4 hypothetical protein YP_003065907.1 172731 D 661410 CDS YP_003065908.1 254558813 8190660 173951..174298 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 174298 8190660 METDI0174 Methylobacterium extorquens DM4 hypothetical protein YP_003065908.1 173951 D 661410 CDS YP_003065909.1 254558814 8190661 complement(174376..176256) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type e : enzyme; putative Acylaminoacyl-peptidase 176256 8190661 METDI0175 Methylobacterium extorquens DM4 putative Acylaminoacyl-peptidase YP_003065909.1 174376 R 661410 CDS YP_003065910.1 254558815 8190662 complement(176325..177203) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 177203 8190662 METDI0176 Methylobacterium extorquens DM4 hypothetical protein YP_003065910.1 176325 R 661410 CDS YP_003065911.1 254558816 8190663 177583..177828 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 177828 8190663 METDI0177 Methylobacterium extorquens DM4 hypothetical protein YP_003065911.1 177583 D 661410 CDS YP_003065912.1 254558817 8190664 177960..179207 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; ATP-dependent dsDNA exonuclease 179207 sbcD 8190664 sbcD Methylobacterium extorquens DM4 ATP-dependent dsDNA exonuclease YP_003065912.1 177960 D 661410 CDS YP_003065913.1 254558818 8196099 179219..182965 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; Nuclease sbcCD subunit C 182965 sbcC 8196099 sbcC Methylobacterium extorquens DM4 Nuclease sbcCD subunit C YP_003065913.1 179219 D 661410 CDS YP_003065914.1 254558819 8196098 183228..184487 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative nitrate transporter narK 184487 narK 8196098 narK Methylobacterium extorquens DM4 putative nitrate transporter narK YP_003065914.1 183228 D 661410 CDS YP_003065915.1 254558820 8195771 complement(184570..185337) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type e : enzyme; putative phosphoribosyltransferase 185337 8195771 METDI0181 Methylobacterium extorquens DM4 putative phosphoribosyltransferase YP_003065915.1 184570 R 661410 CDS YP_003065916.1 254558821 8190665 complement(185367..185594) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 185594 8190665 METDI0182 Methylobacterium extorquens DM4 hypothetical protein YP_003065916.1 185367 R 661410 CDS YP_003065917.1 254558822 8190666 185798..186691 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 186691 8190666 METDI0183 Methylobacterium extorquens DM4 hypothetical protein YP_003065917.1 185798 D 661410 CDS YP_003065918.1 254558823 8190667 186688..187044 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 187044 8190667 METDI0184 Methylobacterium extorquens DM4 hypothetical protein YP_003065918.1 186688 D 661410 CDS YP_003065919.1 254558824 8190668 complement(187053..188594) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 188594 8190668 METDI0185 Methylobacterium extorquens DM4 hypothetical protein YP_003065919.1 187053 R 661410 CDS YP_003065920.1 254558825 8190669 complement(188626..189042) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type e : enzyme; putative mutator MutT protein precursor; putative NTP pyrophosphohydrolase 189042 8190669 METDI0186 Methylobacterium extorquens DM4 putative mutator MutT protein precursor; putative NTP pyrophosphohydrolase YP_003065920.1 188626 R 661410 CDS YP_003065921.1 254558826 8190670 complement(189039..189761) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 189761 8190670 METDI0187 Methylobacterium extorquens DM4 hypothetical protein YP_003065921.1 189039 R 661410 CDS YP_003065922.1 254558827 8190671 complement(189758..191002) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; glutamate N-acetyltransferase/amino-acid acetyltransferase 191002 argJ 8190671 argJ Methylobacterium extorquens DM4 glutamate N-acetyltransferase/amino-acid acetyltransferase YP_003065922.1 189758 R 661410 CDS YP_003065923.1 254558828 8195090 191384..191854 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 191854 8195090 METDI0189 Methylobacterium extorquens DM4 hypothetical protein YP_003065923.1 191384 D 661410 CDS YP_003065924.1 254558829 8190672 191947..192501 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative glutathione peroxidase 192501 8190672 METDI0190 Methylobacterium extorquens DM4 putative glutathione peroxidase YP_003065924.1 191947 D 661410 CDS YP_003065925.1 254558830 8190673 complement(192518..192784) 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 192784 8190673 METDI0191 Methylobacterium extorquens DM4 hypothetical protein YP_003065925.1 192518 R 661410 CDS YP_003065926.1 254558831 8190674 192844..193071 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 193071 8190674 METDI0192 Methylobacterium extorquens DM4 hypothetical protein YP_003065926.1 192844 D 661410 CDS YP_003065927.1 254558832 8190675 193262..193504 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 193504 8190675 METDI0193 Methylobacterium extorquens DM4 hypothetical protein YP_003065927.1 193262 D 661410 CDS YP_003065928.1 254558833 8190676 complement(193511..196603) 1 NC_012988.1 proline utilization protein A; multifunctional protein that functions in proline catabolism in the first two enzymatic steps resulting in the conversion of proline to glutamate; in Escherichia coli this protein self regulates transcription via a DNA-binding domain at the N-terminus but the proteins from this group do not and in addition appear to have a truncated C-terminal domain; bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase 196603 putA 8190676 putA Methylobacterium extorquens DM4 bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase YP_003065928.1 193511 R 661410 CDS YP_003065929.1 254558834 8195941 complement(196706..200233) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 200233 8195941 METDI0195 Methylobacterium extorquens DM4 hypothetical protein YP_003065929.1 196706 R 661410 CDS YP_003065930.1 254558835 8190677 complement(200394..200645) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 200645 8190677 METDI0196 Methylobacterium extorquens DM4 hypothetical protein YP_003065930.1 200394 R 661410 CDS YP_003065931.1 254558836 8190678 200761..203148 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 2254268, 2943729, 6324092, 6379604, 8419285, 91193215, 93328668, 93341925; Product type e : enzyme; DNA-dependent ATPase I and helicase II 203148 uvrD 8190678 uvrD Methylobacterium extorquens DM4 DNA-dependent ATPase I and helicase II YP_003065931.1 200761 D 661410 CDS YP_003065932.1 254558837 8196332 complement(203278..203517) 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 203517 8196332 METDI0198 Methylobacterium extorquens DM4 hypothetical protein YP_003065932.1 203278 R 661410 CDS YP_003065933.1 254558838 8190679 203545..204261 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 2160940; Product type pe : putative enzyme; putative phosphate starvation induced PhoH-like protein 204261 8190679 METDI0199 Methylobacterium extorquens DM4 putative phosphate starvation induced PhoH-like protein YP_003065933.1 203545 D 661410 CDS YP_003065934.1 254558839 8190680 complement(204331..205071) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 96094287, 99328963, 99448397; Product type t : transporter; water channel (aquaporin Z) (MIP family) 205071 aqpZ 8190680 aqpZ Methylobacterium extorquens DM4 water channel (aquaporin Z) (MIP family) YP_003065934.1 204331 R 661410 CDS YP_003065935.1 254558840 8195079 complement(205453..206346) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 206346 8195079 METDI0201 Methylobacterium extorquens DM4 hypothetical protein YP_003065935.1 205453 R 661410 CDS YP_003065936.1 254558841 8190681 complement(206397..209360) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 11214968; Product type e : enzyme; Glutamate-ammonia-ligase adenylyltransferase ([Glutamate--ammonia-ligase] adenylyltransferase) (Glutamine-synthetase adenylyltransferase) (ATase) 209360 glnE 8190681 glnE Methylobacterium extorquens DM4 Glutamate-ammonia-ligase adenylyltransferase ([Glutamate--ammonia-ligase] adenylyltransferase) (Glutamine-synthetase adenylyltransferase) (ATase) YP_003065936.1 206397 R 661410 CDS YP_003065937.1 254558842 8195500 complement(209602..210297) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 210297 8195500 METDI0203 Methylobacterium extorquens DM4 hypothetical protein YP_003065937.1 209602 R 661410 CDS YP_003065938.1 254558843 8190682 210633..210929 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 210929 8190682 METDI0204 Methylobacterium extorquens DM4 hypothetical protein YP_003065938.1 210633 D 661410 CDS YP_003065939.1 254558844 8190683 complement(210937..212367) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type prc : putative receptor; putative sensor histidine kinase; putative membrane protein 212367 8190683 METDI0205 Methylobacterium extorquens DM4 putative sensor histidine kinase; putative membrane protein YP_003065939.1 210937 R 661410 CDS YP_003065940.1 254558845 8190684 complement(212364..213062) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 11283292, 11399769, 20461235; Product type r : regulator; response regulator in two-component regulatory system with CusS, regulation of copper resistance 213062 cusR 8190684 cusR Methylobacterium extorquens DM4 response regulator in two-component regulatory system with CusS, regulation of copper resistance YP_003065940.1 212364 R 661410 CDS YP_003065941.1 254558846 8195231 complement(213089..213598) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 213598 8195231 METDI0207 Methylobacterium extorquens DM4 hypothetical protein YP_003065941.1 213089 R 661410 CDS YP_003065942.1 254558847 8190685 complement(213675..214454) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 20245523, 3549459, 7984428, 99410391, 99436146; Product type t : transporter; alkanesulfonate transport protein (ABC superfamily, atp_bind) 214454 ssuB 8190685 ssuB Methylobacterium extorquens DM4 alkanesulfonate transport protein (ABC superfamily, atp_bind) YP_003065942.1 213675 R 661410 CDS YP_003065943.1 254558848 8196154 complement(214462..215301) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type t : transporter; alkanesulfonate transporter subunit ; membrane component of ABC superfamily 215301 ssuC 8196154 ssuC Methylobacterium extorquens DM4 alkanesulfonate transporter subunit ; membrane component of ABC superfamily YP_003065943.1 214462 R 661410 CDS YP_003065944.1 254558849 8196158 complement(215362..215994) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type t : transporter; transporter protein 215994 8196158 METDI0210 Methylobacterium extorquens DM4 transporter protein YP_003065944.1 215362 R 661410 CDS YP_003065945.1 254558850 8190686 complement(216003..216977) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type t : transporter; sulfonate transport system substrate-binding protein 216977 8190686 METDI0211 Methylobacterium extorquens DM4 sulfonate transport system substrate-binding protein YP_003065945.1 216003 R 661410 CDS YP_003065946.1 254558851 8190687 217137..219923 1 NC_012988.1 catalyzes the uridylylation or deuridylylation of the PII nitrogen regulatory protein; PII uridylyl-transferase 219923 glnD 8190687 glnD Methylobacterium extorquens DM4 PII uridylyl-transferase YP_003065946.1 217137 D 661410 CDS YP_003065947.1 254558852 8195499 220015..220623 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor; putative heat shock protein (HSP-70 COFACTOR), grpE 220623 8195499 METDI0213 Methylobacterium extorquens DM4 putative heat shock protein (HSP-70 COFACTOR), grpE YP_003065947.1 220015 D 661410 CDS YP_003065948.1 254558853 8190688 complement(220732..221067) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 221067 8190688 METDI0214 Methylobacterium extorquens DM4 hypothetical protein YP_003065948.1 220732 R 661410 CDS YP_003065949.1 254558854 8190689 complement(221039..221314) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 221314 8190689 METDI0215 Methylobacterium extorquens DM4 hypothetical protein YP_003065949.1 221039 R 661410 CDS YP_003065950.1 254558855 8190690 complement(221406..222263) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative Prephenate dehydratase 222263 8190690 METDI0216 Methylobacterium extorquens DM4 putative Prephenate dehydratase YP_003065950.1 221406 R 661410 CDS YP_003065951.1 254558856 8190691 complement(222280..223023) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 3023327; Product type e : enzyme; 3-deoxy-manno-octulosonate cytidylyltransferase 223023 kdsB 8190691 kdsB Methylobacterium extorquens DM4 3-deoxy-manno-octulosonate cytidylyltransferase YP_003065951.1 222280 R 661410 CDS YP_003065952.1 254558857 8195620 223331..224248 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type c : carrier; putative cytochrome c, class I 224248 8195620 METDI0218 Methylobacterium extorquens DM4 putative cytochrome c, class I YP_003065952.1 223331 D 661410 CDS YP_003065953.1 254558858 8190692 224421..226334 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative ABC transporter, periplasmic protein precursor 226334 8190692 METDI0219 Methylobacterium extorquens DM4 putative ABC transporter, periplasmic protein precursor YP_003065953.1 224421 D 661410 CDS YP_003065954.1 254558859 8190693 226331..228193 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative ABC transporter, periplasmic protein precursor 228193 8190693 METDI0220 Methylobacterium extorquens DM4 putative ABC transporter, periplasmic protein precursor YP_003065954.1 226331 D 661410 CDS YP_003065955.1 254558860 8190694 228203..229300 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative ABC transporter, permease 229300 8190694 METDI0221 Methylobacterium extorquens DM4 putative ABC transporter, permease YP_003065955.1 228203 D 661410 CDS YP_003065956.1 254558861 8190695 229369..229872 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative acyltransferase with acyl-CoA N-acyltransferase domain 229872 8190695 METDI0222 Methylobacterium extorquens DM4 putative acyltransferase with acyl-CoA N-acyltransferase domain YP_003065956.1 229369 D 661410 CDS YP_003065957.1 254558862 8190696 229986..231518 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative Long-chain acyl-CoA synthetase 231518 8190696 METDI0223 Methylobacterium extorquens DM4 putative Long-chain acyl-CoA synthetase YP_003065957.1 229986 D 661410 CDS YP_003065958.1 254558863 8190697 231579..232361 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8824620; Product type pe : putative enzyme; putative lipopolysaccharide core biosynthesis glycosyl transferase (LpsC-like, kdtX-like) 232361 8190697 METDI0224 Methylobacterium extorquens DM4 putative lipopolysaccharide core biosynthesis glycosyl transferase (LpsC-like, kdtX-like) YP_003065958.1 231579 D 661410 CDS YP_003065959.1 254558864 8196261 complement(232539..233249) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor; putative DNA-binding protein; putative AP2/ERF domain 233249 8196261 METDI0225 Methylobacterium extorquens DM4 putative DNA-binding protein; putative AP2/ERF domain YP_003065959.1 232539 R 661410 CDS YP_003065960.1 254558865 8190699 complement(233465..233749) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 233749 8190699 METDI0226 Methylobacterium extorquens DM4 hypothetical protein YP_003065960.1 233465 R 661410 CDS YP_003065961.1 254558866 8190700 complement(233746..234264) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 234264 8190700 METDI0227 Methylobacterium extorquens DM4 hypothetical protein YP_003065961.1 233746 R 661410 CDS YP_003065962.1 254558867 8190701 234279..234455 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 234455 8190701 METDI0228 Methylobacterium extorquens DM4 hypothetical protein YP_003065962.1 234279 D 661410 CDS YP_003065963.1 254558868 8190702 234854..236551 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative AAA ATPase domain protein 236551 8190702 METDI0229 Methylobacterium extorquens DM4 putative AAA ATPase domain protein YP_003065963.1 234854 D 661410 CDS YP_003065964.1 254558869 8190703 236548..236793 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 236793 8190703 METDI0230 Methylobacterium extorquens DM4 hypothetical protein YP_003065964.1 236548 D 661410 CDS YP_003065965.1 254558870 8190704 236778..237386 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 237386 8190704 METDI0231 Methylobacterium extorquens DM4 hypothetical protein YP_003065965.1 236778 D 661410 CDS YP_003065966.1 254558871 8190705 237422..238006 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 238006 8190705 METDI0232 Methylobacterium extorquens DM4 hypothetical protein YP_003065966.1 237422 D 661410 CDS YP_003065967.1 254558872 8190706 238003..238437 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 238437 8190706 METDI0233 Methylobacterium extorquens DM4 hypothetical protein YP_003065967.1 238003 D 661410 CDS YP_003065968.1 254558873 8190709 239025..239336 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 239336 8190709 METDI0236 Methylobacterium extorquens DM4 hypothetical protein YP_003065968.1 239025 D 661410 CDS YP_003065969.1 254558874 8190710 239600..239803 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 239803 8190710 METDI0238 Methylobacterium extorquens DM4 hypothetical protein YP_003065969.1 239600 D 661410 CDS YP_003065970.1 254558875 8190711 complement(239861..240118) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 240118 8190711 METDI0239 Methylobacterium extorquens DM4 hypothetical protein YP_003065970.1 239861 R 661410 CDS YP_003065971.1 254558876 8190712 240928..241275 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 241275 8190712 METDI0241 Methylobacterium extorquens DM4 hypothetical protein YP_003065971.1 240928 D 661410 CDS YP_003065972.1 254558877 8190713 241338..241586 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 241586 8190713 METDI0242 Methylobacterium extorquens DM4 hypothetical protein YP_003065972.1 241338 D 661410 CDS YP_003065973.1 254558878 8190714 241763..241828 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 241828 8190714 METDI0243 Methylobacterium extorquens DM4 hypothetical protein YP_003065973.1 241763 D 661410 CDS YP_003065974.1 254558879 8190715 241953..242165 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 242165 8190715 METDI0244 Methylobacterium extorquens DM4 hypothetical protein YP_003065974.1 241953 D 661410 CDS YP_003065975.1 254558880 8190717 complement(242489..242698) 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 242698 8190717 METDI0246 Methylobacterium extorquens DM4 hypothetical protein YP_003065975.1 242489 R 661410 CDS YP_003065976.1 254558881 8190718 242673..244754 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative histidine kinase and two component hybrid sensor and regulator; putative membrane protein 244754 8190718 METDI0247 Methylobacterium extorquens DM4 putative histidine kinase and two component hybrid sensor and regulator; putative membrane protein YP_003065976.1 242673 D 661410 CDS YP_003065977.1 254558882 8190719 244812..245063 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 245063 8190719 METDI0248 Methylobacterium extorquens DM4 hypothetical protein YP_003065977.1 244812 D 661410 CDS YP_003065978.1 254558883 8190720 245176..246444 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 12597275; Product type e : enzyme; signal transduction histidine kinase; GAF domain 246444 8190720 METDI0249 Methylobacterium extorquens DM4 signal transduction histidine kinase; GAF domain YP_003065978.1 245176 D 661410 CDS YP_003065979.1 254558884 8190721 complement(246551..246742) 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 246742 8190721 METDI0250 Methylobacterium extorquens DM4 hypothetical protein YP_003065979.1 246551 R 661410 CDS YP_003065980.1 254558885 8190722 complement(246739..247050) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 247050 8190722 METDI0251 Methylobacterium extorquens DM4 hypothetical protein YP_003065980.1 246739 R 661410 CDS YP_003065981.1 254558886 8190723 complement(247242..248813) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative diguanylate cyclase (GGDEF motif) 248813 8190723 METDI0252 Methylobacterium extorquens DM4 putative diguanylate cyclase (GGDEF motif) YP_003065981.1 247242 R 661410 CDS YP_003065982.1 254558887 8190724 complement(249502..250470) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type r : regulator; transcriptional regulator, LysR family 250470 8190724 METDI0253 Methylobacterium extorquens DM4 transcriptional regulator, LysR family YP_003065982.1 249502 R 661410 CDS YP_003065983.1 254558888 8190725 complement(250603..253731) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type t : transporter; Hydrophobe/Amphiphile Efflux-1 (HAE1) 253731 acrB 8190725 acrB Methylobacterium extorquens DM4 Hydrophobe/Amphiphile Efflux-1 (HAE1) YP_003065983.1 250603 R 661410 CDS YP_003065984.1 254558889 8195054 complement(253771..254802) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 15047512, 8878035; Product type t : transporter; RND efflux transporter, membrane fusion protein subunit 254802 8195054 METDI0255 Methylobacterium extorquens DM4 RND efflux transporter, membrane fusion protein subunit YP_003065984.1 253771 R 661410 CDS YP_003065985.1 254558890 8190726 255340..255819 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor; putative molecular chaperone, heat shock Hsp20 family 255819 8190726 METDI0256 Methylobacterium extorquens DM4 putative molecular chaperone, heat shock Hsp20 family YP_003065985.1 255340 D 661410 CDS YP_003065986.1 254558891 8190727 255819..256688 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type r : regulator; transcriptional regulator, Crp/Fnr family 256688 8190727 METDI0257 Methylobacterium extorquens DM4 transcriptional regulator, Crp/Fnr family YP_003065986.1 255819 D 661410 CDS YP_003065987.1 254558892 8190728 complement(256702..257520) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor; putative Universal stress protein, UspA 257520 8190728 METDI0258 Methylobacterium extorquens DM4 putative Universal stress protein, UspA YP_003065987.1 256702 R 661410 CDS YP_003065988.1 254558893 8190731 complement(258580..258957) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 258957 8190731 METDI0263 Methylobacterium extorquens DM4 hypothetical protein YP_003065988.1 258580 R 661410 CDS YP_003065989.1 254558894 8190732 complement(258954..259331) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 259331 8190732 METDI0264 Methylobacterium extorquens DM4 hypothetical protein YP_003065989.1 258954 R 661410 CDS YP_003065990.1 254558895 8190733 complement(259399..259638) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor; putative biotin/lipoyl attachment domain 259638 8190733 METDI0265 Methylobacterium extorquens DM4 putative biotin/lipoyl attachment domain YP_003065990.1 259399 R 661410 CDS YP_003065991.1 254558896 8190734 259833..260351 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 260351 8190734 METDI0266 Methylobacterium extorquens DM4 hypothetical protein YP_003065991.1 259833 D 661410 CDS YP_003065992.1 254558897 8190735 260435..260650 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 260650 8190735 METDI0267 Methylobacterium extorquens DM4 hypothetical protein YP_003065992.1 260435 D 661410 CDS YP_003065993.1 254558898 8190736 260660..260917 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 260917 8190736 METDI0268 Methylobacterium extorquens DM4 hypothetical protein YP_003065993.1 260660 D 661410 CDS YP_003065994.1 254558899 8190737 260914..262245 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative manganese transporter 262245 8190737 METDI0269 Methylobacterium extorquens DM4 putative manganese transporter YP_003065994.1 260914 D 661410 CDS YP_003065995.1 254558900 8190738 262311..262763 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 262763 8190738 METDI0270 Methylobacterium extorquens DM4 hypothetical protein YP_003065995.1 262311 D 661410 CDS YP_003065996.1 254558901 8190739 262813..263460 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pt : putative transporter; hypothetical protein 263460 8190739 METDI0271 Methylobacterium extorquens DM4 hypothetical protein YP_003065996.1 262813 D 661410 CDS YP_003065997.1 254558902 8190740 263547..264356 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 264356 8190740 METDI0272 Methylobacterium extorquens DM4 hypothetical protein YP_003065997.1 263547 D 661410 CDS YP_003065998.1 254558903 8190741 264357..264632 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 264632 8190741 METDI0273 Methylobacterium extorquens DM4 hypothetical protein YP_003065998.1 264357 D 661410 CDS YP_003065999.1 254558904 8190742 complement(264698..265558) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 265558 8190742 METDI0274 Methylobacterium extorquens DM4 hypothetical protein YP_003065999.1 264698 R 661410 CDS YP_003066000.1 254558905 8190743 complement(265574..265906) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 265906 8190743 METDI0275 Methylobacterium extorquens DM4 hypothetical protein YP_003066000.1 265574 R 661410 CDS YP_003066001.1 254558906 8190744 complement(265906..266721) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 266721 8190744 METDI0276 Methylobacterium extorquens DM4 hypothetical protein YP_003066001.1 265906 R 661410 CDS YP_003066002.1 254558907 8190745 complement(266800..267000) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 267000 8190745 METDI0277 Methylobacterium extorquens DM4 hypothetical protein YP_003066002.1 266800 R 661410 CDS YP_003066003.1 254558908 8190746 267269..267487 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 267487 8190746 METDI0278 Methylobacterium extorquens DM4 hypothetical protein YP_003066003.1 267269 D 661410 CDS YP_003066004.1 254558909 8190747 267313..267648 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 267648 8190747 METDI0279 Methylobacterium extorquens DM4 hypothetical protein YP_003066004.1 267313 D 661410 CDS YP_003066005.1 254558910 8190748 267623..268219 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier; putative Cytochrome b561 (Cytochrome b-561) 268219 8190748 METDI0280 Methylobacterium extorquens DM4 putative Cytochrome b561 (Cytochrome b-561) YP_003066005.1 267623 D 661410 CDS YP_003066006.1 254558911 8190749 268225..268920 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; hypothetical protein 268920 8190749 METDI0281 Methylobacterium extorquens DM4 hypothetical protein YP_003066006.1 268225 D 661410 CDS YP_003066007.1 254558912 8190750 268930..269139 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 269139 8190750 METDI0282 Methylobacterium extorquens DM4 hypothetical protein YP_003066007.1 268930 D 661410 CDS YP_003066008.1 254558913 8190751 complement(269220..270203) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 1735726; Product type pe : putative enzyme; putative Zn-containing alcohol dehydrogenase (ADH) 270203 8190751 METDI0283 Methylobacterium extorquens DM4 putative Zn-containing alcohol dehydrogenase (ADH) YP_003066008.1 269220 R 661410 CDS YP_003066009.1 254558914 8190752 complement(270213..270860) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 270860 8190752 METDI0284 Methylobacterium extorquens DM4 hypothetical protein YP_003066009.1 270213 R 661410 CDS YP_003066010.1 254558915 8190753 complement(270890..271090) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 271090 8190753 METDI0285 Methylobacterium extorquens DM4 hypothetical protein YP_003066010.1 270890 R 661410 CDS YP_003066011.1 254558916 8190754 271224..273809 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 11292814, 11823225; Product type e : enzyme; putative phosphoketolase 273809 xfp 8190754 xfp Methylobacterium extorquens DM4 putative phosphoketolase YP_003066011.1 271224 D 661410 CDS YP_003066012.1 254558917 8196339 273940..274137 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 274137 8196339 METDI0287 Methylobacterium extorquens DM4 hypothetical protein YP_003066012.1 273940 D 661410 CDS YP_003066013.1 254558918 8190755 274308..276932 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 14550559, 14640692, 91294166, 93015925, 93388583, 99428468; Product type f : factor; protein disaggregation chaperone 276932 clpB 8190755 clpB Methylobacterium extorquens DM4 protein disaggregation chaperone YP_003066013.1 274308 D 661410 CDS YP_003066014.1 254558919 8195169 277549..278454 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor; Chaperone DnaJ domain protein, putative heat shock protein 278454 8195169 METDI0289 Methylobacterium extorquens DM4 Chaperone DnaJ domain protein, putative heat shock protein YP_003066014.1 277549 D 661410 CDS YP_003066015.1 254558920 8190756 278458..278760 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; conserved DnaJ-associated protein of unknown function; putative transcriptional regulator 278760 8190756 METDI0290 Methylobacterium extorquens DM4 conserved DnaJ-associated protein of unknown function; putative transcriptional regulator YP_003066015.1 278458 D 661410 CDS YP_003066016.1 254558921 8190757 278757..279098 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 279098 8190757 METDI0291 Methylobacterium extorquens DM4 hypothetical protein YP_003066016.1 278757 D 661410 CDS YP_003066017.1 254558922 8190758 278944..280791 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative poly-beta-hydroxyalkanoate synthase (phbC) 280791 8190758 METDI0292 Methylobacterium extorquens DM4 putative poly-beta-hydroxyalkanoate synthase (phbC) YP_003066017.1 278944 D 661410 CDS YP_003066018.1 254558923 8190759 280788..281570 1 NC_012988.1 Catalyzes a key regulatory step in fatty acid biosynthesis; enoyl-(acyl carrier protein) reductase 281570 fabI 8190759 fabI Methylobacterium extorquens DM4 enoyl-(acyl carrier protein) reductase YP_003066018.1 280788 D 661410 CDS YP_003066019.1 254558924 8195347 281586..282983 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; bifunctional enoyl-CoA hydratase/phosphate acetyltransferase 282983 8195347 METDI0294 Methylobacterium extorquens DM4 bifunctional enoyl-CoA hydratase/phosphate acetyltransferase YP_003066019.1 281586 D 661410 CDS YP_003066020.1 254558925 8190760 282980..284167 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative acetate kinase (ackA) 284167 8190760 METDI0295 Methylobacterium extorquens DM4 putative acetate kinase (ackA) YP_003066020.1 282980 D 661410 CDS YP_003066021.1 254558926 8190762 complement(284876..285352) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 285352 8190762 METDI0297 Methylobacterium extorquens DM4 hypothetical protein YP_003066021.1 284876 R 661410 CDS YP_003066022.1 254558927 8190763 complement(285363..286013) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; hypothetical protein 286013 8190763 METDI0298 Methylobacterium extorquens DM4 hypothetical protein YP_003066022.1 285363 R 661410 CDS YP_003066023.1 254558928 8190764 complement(286067..286411) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 286411 8190764 METDI0299 Methylobacterium extorquens DM4 hypothetical protein YP_003066023.1 286067 R 661410 CDS YP_003066024.1 254558929 8190765 286572..286970 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 286970 8190765 METDI0300 Methylobacterium extorquens DM4 hypothetical protein YP_003066024.1 286572 D 661410 CDS YP_003066025.1 254558930 8190766 286936..289653 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type t : transporter; Cation-transporting ATPase 289653 8190766 METDI0301 Methylobacterium extorquens DM4 Cation-transporting ATPase YP_003066025.1 286936 D 661410 CDS YP_003066026.1 254558931 8190767 289760..290620 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 290620 8190767 METDI0302 Methylobacterium extorquens DM4 hypothetical protein YP_003066026.1 289760 D 661410 CDS YP_003066027.1 254558932 8190768 complement(290982..291305) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 291305 8190768 METDI0303 Methylobacterium extorquens DM4 hypothetical protein YP_003066027.1 290982 R 661410 CDS YP_003066028.1 254558933 8190769 complement(291565..292029) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 292029 8190769 METDI0304 Methylobacterium extorquens DM4 hypothetical protein YP_003066028.1 291565 R 661410 CDS YP_003066029.1 254558934 8190770 complement(292124..292810) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; nitrogen fixation transcriptional regulator fixK2, Crp/Fnr family 292810 fixK2 8190770 fixK2 Methylobacterium extorquens DM4 nitrogen fixation transcriptional regulator fixK2, Crp/Fnr family YP_003066029.1 292124 R 661410 CDS YP_003066030.1 254558935 8195380 complement(292934..293206) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 293206 8195380 METDI0306 Methylobacterium extorquens DM4 hypothetical protein YP_003066030.1 292934 R 661410 CDS YP_003066031.1 254558936 8190771 complement(293242..293322) 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 293322 8190771 METDI0307 Methylobacterium extorquens DM4 hypothetical protein YP_003066031.1 293242 R 661410 CDS YP_003066032.1 254558937 8190772 complement(293319..293534) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 293534 8190772 METDI0308 Methylobacterium extorquens DM4 hypothetical protein YP_003066032.1 293319 R 661410 CDS YP_003066033.1 254558938 8190773 complement(293766..294089) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 294089 8190773 METDI0309 Methylobacterium extorquens DM4 hypothetical protein YP_003066033.1 293766 R 661410 CDS YP_003066034.1 254558939 8190774 complement(294004..294216) 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 294216 8190774 METDI0310 Methylobacterium extorquens DM4 hypothetical protein YP_003066034.1 294004 R 661410 CDS YP_003066035.1 254558940 8190775 294379..294663 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 294663 8190775 METDI0311 Methylobacterium extorquens DM4 hypothetical protein YP_003066035.1 294379 D 661410 CDS YP_003066036.1 254558941 8190776 294654..294839 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 294839 8190776 METDI0312 Methylobacterium extorquens DM4 hypothetical protein YP_003066036.1 294654 D 661410 CDS YP_003066037.1 254558942 8190777 complement(294917..295036) 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 295036 8190777 METDI0313 Methylobacterium extorquens DM4 hypothetical protein YP_003066037.1 294917 R 661410 CDS YP_003066038.1 254558943 8190778 complement(295151..295933) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type e : enzyme; transposase of ISMdi17, IS5 family 295933 8190778 METDI0314 Methylobacterium extorquens DM4 transposase of ISMdi17, IS5 family YP_003066038.1 295151 R 661410 CDS YP_003066039.1 254558944 8190779 complement(296144..297094) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type e : enzyme; transposase of ISMdi8, IS481 family 297094 8190779 METDI0315 Methylobacterium extorquens DM4 transposase of ISMdi8, IS481 family YP_003066039.1 296144 R 661410 CDS YP_003066040.1 254558945 8190780 complement(297231..298565) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type e : enzyme; transposase of ISMdi6, IS1182 family 298565 8190780 METDI0316 Methylobacterium extorquens DM4 transposase of ISMdi6, IS1182 family YP_003066040.1 297231 R 661410 CDS YP_003066041.1 254558946 8190781 complement(299121..299513) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative two component response regulator (FixJ domain-like) 299513 8190781 METDI0317 Methylobacterium extorquens DM4 putative two component response regulator (FixJ domain-like) YP_003066041.1 299121 R 661410 CDS YP_003066042.1 254558947 8190782 complement(299603..300211) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type r : regulator; two component transcriptional regulator, LuxR family; putative nitrogen fixation transcriptional regulator FixJ 300211 fixJ 8190782 fixJ Methylobacterium extorquens DM4 two component transcriptional regulator, LuxR family; putative nitrogen fixation transcriptional regulator FixJ YP_003066042.1 299603 R 661410 CDS YP_003066043.1 254558948 8195377 complement(300201..301751) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type r : regulator; two component low oxygen sensor histidine kinase with PAS domains; FixL 301751 fixL 8195377 fixL Methylobacterium extorquens DM4 two component low oxygen sensor histidine kinase with PAS domains; FixL YP_003066043.1 300201 R 661410 CDS YP_003066044.1 254558949 8195382 302072..302932 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor; putative universal stress protein, UspA 302932 8195382 METDI0320 Methylobacterium extorquens DM4 putative universal stress protein, UspA YP_003066044.1 302072 D 661410 CDS YP_003066045.1 254558950 8190783 302949..303161 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 303161 8190783 METDI0321 Methylobacterium extorquens DM4 hypothetical protein YP_003066045.1 302949 D 661410 CDS YP_003066046.1 254558951 8190784 complement(303248..303583) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier; putative cytochrome c, class I 303583 8190784 METDI0322 Methylobacterium extorquens DM4 putative cytochrome c, class I YP_003066046.1 303248 R 661410 CDS YP_003066047.1 254558952 8190785 complement(303583..304395) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative Universal stress protein, UspA 304395 8190785 METDI0323 Methylobacterium extorquens DM4 putative Universal stress protein, UspA YP_003066047.1 303583 R 661410 CDS YP_003066048.1 254558953 8190786 complement(304490..306415) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11481432; Product type pt : putative transporter; putative cation transport P-type ATPase 306415 8190786 METDI0324 Methylobacterium extorquens DM4 putative cation transport P-type ATPase YP_003066048.1 304490 R 661410 CDS YP_003066049.1 254558954 8190787 complement(306792..307625) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; transposase of ISMdi8, IS481 family 307625 8190787 METDI0325 Methylobacterium extorquens DM4 transposase of ISMdi8, IS481 family YP_003066049.1 306792 R 661410 CDS YP_003066050.1 254558955 8190788 308146..310359 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative sensory box-containing diguanylate cyclase/phosphodiesterase, PAS/PAC, GGDEF and EAL domains 310359 8190788 METDI0326 Methylobacterium extorquens DM4 putative sensory box-containing diguanylate cyclase/phosphodiesterase, PAS/PAC, GGDEF and EAL domains YP_003066050.1 308146 D 661410 CDS YP_003066051.1 254558956 8190789 complement(310593..310763) 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 310763 8190789 METDI0327 Methylobacterium extorquens DM4 hypothetical protein YP_003066051.1 310593 R 661410 CDS YP_003066052.1 254558957 8190790 311020..311472 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 311472 8190790 METDI0328 Methylobacterium extorquens DM4 hypothetical protein YP_003066052.1 311020 D 661410 CDS YP_003066053.1 254558958 8190791 311743..312966 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative secretion protein precursor, putative RND family efflux protein 312966 8190791 METDI0329 Methylobacterium extorquens DM4 putative secretion protein precursor, putative RND family efflux protein YP_003066053.1 311743 D 661410 CDS YP_003066054.1 254558959 8190792 312970..316260 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 7766206; Product type t : transporter; Cation efflux system protein czcA 316260 czcA 8190792 czcA Methylobacterium extorquens DM4 Cation efflux system protein czcA YP_003066054.1 312970 D 661410 CDS YP_003066055.1 254558960 8195264 complement(316411..316707) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 316707 8195264 METDI0331 Methylobacterium extorquens DM4 hypothetical protein YP_003066055.1 316411 R 661410 CDS YP_003066056.1 254558961 8190793 complement(316833..319127) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11587643; Product type pe : putative enzyme; putative glycosyl hydrolase 319127 8190793 METDI0332 Methylobacterium extorquens DM4 putative glycosyl hydrolase YP_003066056.1 316833 R 661410 CDS YP_003066057.1 254558962 8190794 complement(319124..319894) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative haloacid dehalogenase-like hydrolase 319894 8190794 METDI0333 Methylobacterium extorquens DM4 putative haloacid dehalogenase-like hydrolase YP_003066057.1 319124 R 661410 CDS YP_003066058.1 254558963 8190795 319920..320309 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 320309 8190795 METDI0334 Methylobacterium extorquens DM4 hypothetical protein YP_003066058.1 319920 D 661410 CDS YP_003066059.1 254558964 8190796 321047..321370 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcriptional regulator, ArsR family 321370 8190796 METDI0335 Methylobacterium extorquens DM4 putative transcriptional regulator, ArsR family YP_003066059.1 321047 D 661410 CDS YP_003066060.1 254558965 8190797 complement(321758..323071) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type prc : putative receptor; putative integral membrane sensor signal transduction histidine kinase precursor 323071 8190797 METDI0337 Methylobacterium extorquens DM4 putative integral membrane sensor signal transduction histidine kinase precursor YP_003066060.1 321758 R 661410 CDS YP_003066061.1 254558966 8190798 complement(323068..323730) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type r : regulator; DNA-binding response regulator in two-component regulatory system 323730 8190798 METDI0338 Methylobacterium extorquens DM4 DNA-binding response regulator in two-component regulatory system YP_003066061.1 323068 R 661410 CDS YP_003066062.1 254558967 8190799 323838..325247 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type e : enzyme; putative thiol:disulfide interchange protein 325247 8190799 METDI0339 Methylobacterium extorquens DM4 putative thiol:disulfide interchange protein YP_003066062.1 323838 D 661410 CDS YP_003066063.1 254558968 8190800 325015..325611 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative thiol:disulfide interchange protein 325611 8190800 METDI0340 Methylobacterium extorquens DM4 putative thiol:disulfide interchange protein YP_003066063.1 325015 D 661410 CDS YP_003066064.1 254558969 8190801 325645..326280 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative thioredoxin domain protein precursor 326280 8190801 METDI0341 Methylobacterium extorquens DM4 putative thioredoxin domain protein precursor YP_003066064.1 325645 D 661410 CDS YP_003066065.1 254558970 8190802 326277..327128 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 327128 8190802 METDI0342 Methylobacterium extorquens DM4 hypothetical protein YP_003066065.1 326277 D 661410 CDS YP_003066066.1 254558971 8190803 327112..327576 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 327576 8190803 METDI0343 Methylobacterium extorquens DM4 hypothetical protein YP_003066066.1 327112 D 661410 CDS YP_003066067.1 254558972 8190804 complement(327612..328070) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 328070 8190804 METDI0344 Methylobacterium extorquens DM4 hypothetical protein YP_003066067.1 327612 R 661410 CDS YP_003066068.1 254558973 8190805 328235..328660 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 328660 8190805 METDI0345 Methylobacterium extorquens DM4 hypothetical protein YP_003066068.1 328235 D 661410 CDS YP_003066069.1 254558974 8190806 328664..329113 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 329113 8190806 METDI0346 Methylobacterium extorquens DM4 hypothetical protein YP_003066069.1 328664 D 661410 CDS YP_003066070.1 254558975 8190807 329113..329919 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 329919 8190807 METDI0347 Methylobacterium extorquens DM4 hypothetical protein YP_003066070.1 329113 D 661410 CDS YP_003066071.1 254558976 8190808 329937..330848 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; beta-lactamase domain protein, putative hydroxyacylglutathione hydrolase 330848 8190808 METDI0348 Methylobacterium extorquens DM4 beta-lactamase domain protein, putative hydroxyacylglutathione hydrolase YP_003066071.1 329937 D 661410 CDS YP_003066072.1 254558977 8190809 complement(331090..331533) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8652661; Product type pe : putative enzyme; hypothetical protein 331533 8190809 METDI0349 Methylobacterium extorquens DM4 hypothetical protein YP_003066072.1 331090 R 661410 CDS YP_003066073.1 254558978 8190810 complement(331650..332534) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; beta-lactamase domain protein 332534 8190810 METDI0350 Methylobacterium extorquens DM4 beta-lactamase domain protein YP_003066073.1 331650 R 661410 CDS YP_003066074.1 254558979 8190811 complement(332572..332784) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 332784 8190811 METDI0351 Methylobacterium extorquens DM4 hypothetical protein YP_003066074.1 332572 R 661410 CDS YP_003066075.1 254558980 8190812 complement(333170..335275) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 11114914; Product type r : regulator; methyl-accepting chemotaxis receptor/sensory transducer precursor; histidine kinase HAMP domain 335275 8190812 METDI0352 Methylobacterium extorquens DM4 methyl-accepting chemotaxis receptor/sensory transducer precursor; histidine kinase HAMP domain YP_003066075.1 333170 R 661410 CDS YP_003066076.1 254558981 8190813 335773..336582 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 1840580, 2155230, 93122525, 93273711, 93328121, 9650256; Product type t : transporter; phosphonate transport protein (ABC superfamily, atp_bind) 336582 phnC 8190813 phnC Methylobacterium extorquens DM4 phosphonate transport protein (ABC superfamily, atp_bind) YP_003066076.1 335773 D 661410 CDS YP_003066077.1 254558982 8195860 336595..337467 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 9791102; Product type pt : putative transporter; putative phosphonate transport system substrate-binding protein 337467 ptxB 8195860 ptxB Methylobacterium extorquens DM4 putative phosphonate transport system substrate-binding protein YP_003066077.1 336595 D 661410 CDS YP_003066078.1 254558983 8195919 337471..338304 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 9791102; Product type t : transporter; putative phosphate permease component of ATP-dependent phosphate uptake system 338304 ptxC 8195919 ptxC Methylobacterium extorquens DM4 putative phosphate permease component of ATP-dependent phosphate uptake system YP_003066078.1 337471 D 661410 CDS YP_003066079.1 254558984 8195920 338313..339332 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 11278981, 9791102; Product type e : enzyme; Phosphonate dehydrogenase (NAD-dependent phosphite dehydrogenase) 339332 ptxD 8195920 ptxD Methylobacterium extorquens DM4 Phosphonate dehydrogenase (NAD-dependent phosphite dehydrogenase) YP_003066079.1 338313 D 661410 CDS YP_003066080.1 254558985 8195921 339358..340218 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15640200; Product type pr : putative regulator; putative transcriptional regulator, LysR family 340218 8195921 METDI0357 Methylobacterium extorquens DM4 putative transcriptional regulator, LysR family YP_003066080.1 339358 D 661410 CDS YP_003066081.1 254558986 8190817 complement(341136..341948) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 7619830; Product type pc : putative carrier; putative cytochrome c 341948 8190817 METDI0362 Methylobacterium extorquens DM4 putative cytochrome c YP_003066081.1 341136 R 661410 CDS YP_003066082.1 254558987 8190818 complement(341945..343567) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10775261; Product type pe : putative enzyme; putative Cytochrome c oxidase, subunit I 343567 8190818 METDI0363 Methylobacterium extorquens DM4 putative Cytochrome c oxidase, subunit I YP_003066082.1 341945 R 661410 CDS YP_003066083.1 254558988 8190819 complement(343557..344120) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10775261; Product type pe : putative enzyme; putative cytochrome c oxidase, subunit II (cbaB) 344120 8190819 METDI0364 Methylobacterium extorquens DM4 putative cytochrome c oxidase, subunit II (cbaB) YP_003066083.1 343557 R 661410 CDS YP_003066084.1 254558989 8190820 complement(344133..344309) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 344309 8190820 METDI0365 Methylobacterium extorquens DM4 hypothetical protein YP_003066084.1 344133 R 661410 CDS YP_003066085.1 254558990 8190821 complement(344314..345570) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 9352901; Product type pc : putative carrier; putative cytochrome c, putative exported protein 345570 8190821 METDI0366 Methylobacterium extorquens DM4 putative cytochrome c, putative exported protein YP_003066085.1 344314 R 661410 CDS YP_003066086.1 254558991 8190822 complement(345582..346181) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier; putative cytochrome c 346181 8190822 METDI0367 Methylobacterium extorquens DM4 putative cytochrome c YP_003066086.1 345582 R 661410 CDS YP_003066087.1 254558992 8190823 346671..347360 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11882718, 8759861; Product type pr : putative regulator; putative transcriptional regulator, Crp/Fnr family 347360 8190823 METDI0368 Methylobacterium extorquens DM4 putative transcriptional regulator, Crp/Fnr family YP_003066087.1 346671 D 661410 CDS YP_003066088.1 254558993 8190824 347567..347797 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 347797 8190824 METDI0369 Methylobacterium extorquens DM4 hypothetical protein YP_003066088.1 347567 D 661410 CDS YP_003066089.1 254558994 8190825 complement(347733..348056) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 348056 8190825 METDI0370 Methylobacterium extorquens DM4 hypothetical protein YP_003066089.1 347733 R 661410 CDS YP_003066090.1 254558995 8190826 complement(348081..348326) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 348326 8190826 METDI0371 Methylobacterium extorquens DM4 hypothetical protein YP_003066090.1 348081 R 661410 CDS YP_003066091.1 254558996 8190827 348595..348990 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative Response regulator; CheY-like protein 348990 8190827 METDI0372 Methylobacterium extorquens DM4 putative Response regulator; CheY-like protein YP_003066091.1 348595 D 661410 CDS YP_003066092.1 254558997 8190828 349296..349742 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 349742 8190828 METDI0373 Methylobacterium extorquens DM4 hypothetical protein YP_003066092.1 349296 D 661410 CDS YP_003066093.1 254558998 8190829 349865..350194 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 350194 8190829 METDI0374 Methylobacterium extorquens DM4 hypothetical protein YP_003066093.1 349865 D 661410 CDS YP_003066094.1 254558999 8190830 complement(350423..350635) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 350635 8190830 METDI0375 Methylobacterium extorquens DM4 hypothetical protein YP_003066094.1 350423 R 661410 CDS YP_003066095.1 254559000 8190831 complement(350656..350970) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 350970 8190831 METDI0376 Methylobacterium extorquens DM4 hypothetical protein YP_003066095.1 350656 R 661410 CDS YP_003066096.1 254559001 8190832 complement(351013..351750) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; Short-chain dehydrogenase/reductase SDR 351750 8190832 METDI0377 Methylobacterium extorquens DM4 Short-chain dehydrogenase/reductase SDR YP_003066096.1 351013 R 661410 CDS YP_003066097.1 254559002 8190833 complement(351847..352830) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative oxidoreductase, aldo/keto reductase family 352830 8190833 METDI0378 Methylobacterium extorquens DM4 putative oxidoreductase, aldo/keto reductase family YP_003066097.1 351847 R 661410 CDS YP_003066098.1 254559003 8190834 352999..353895 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcriptional regulator, LysR family 353895 8190834 METDI0379 Methylobacterium extorquens DM4 putative transcriptional regulator, LysR family YP_003066098.1 352999 D 661410 CDS YP_003066099.1 254559004 8190835 354410..354616 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 354616 8190835 METDI0380 Methylobacterium extorquens DM4 hypothetical protein YP_003066099.1 354410 D 661410 CDS YP_003066100.1 254559005 8190836 354761..354979 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 354979 8190836 METDI0381 Methylobacterium extorquens DM4 hypothetical protein YP_003066100.1 354761 D 661410 CDS YP_003066101.1 254559006 8190837 complement(355367..356248) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 356248 8190837 METDI0382 Methylobacterium extorquens DM4 hypothetical protein YP_003066101.1 355367 R 661410 CDS YP_003066102.1 254559007 8190838 complement(356298..356849) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 10383985, 1472501, 7876185, 8704959; hypothetical protein 356849 8190838 METDI0383 Methylobacterium extorquens DM4 hypothetical protein YP_003066102.1 356298 R 661410 CDS YP_003066103.1 254559008 8190839 complement(357055..357273) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 357273 8190839 METDI0384 Methylobacterium extorquens DM4 hypothetical protein YP_003066103.1 357055 R 661410 CDS YP_003066104.1 254559009 8190840 complement(357400..358680) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 14727089, 3009477, 7984428, 8140616; Product type pt : putative transporter; putative transport protein, SulP family 358680 8190840 METDI0385 Methylobacterium extorquens DM4 putative transport protein, SulP family YP_003066104.1 357400 R 661410 CDS YP_003066105.1 254559010 8190841 359408..360433 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; histone deacetylase family protein 360433 8190841 METDI0386 Methylobacterium extorquens DM4 histone deacetylase family protein YP_003066105.1 359408 D 661410 CDS YP_003066106.1 254559011 8190842 complement(361106..361333) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 361333 8190842 METDI0389 Methylobacterium extorquens DM4 hypothetical protein YP_003066106.1 361106 R 661410 CDS YP_003066107.1 254559012 8190843 361463..365764 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 365764 8190843 METDI0390 Methylobacterium extorquens DM4 hypothetical protein YP_003066107.1 361463 D 661410 CDS YP_003066108.1 254559013 8190844 complement(365722..366657) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 366657 8190844 METDI0391 Methylobacterium extorquens DM4 hypothetical protein YP_003066108.1 365722 R 661410 CDS YP_003066109.1 254559014 8190845 367017..367376 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 367376 8190845 METDI0392 Methylobacterium extorquens DM4 hypothetical protein YP_003066109.1 367017 D 661410 CDS YP_003066110.1 254559015 8190846 367547..368476 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 368476 8190846 METDI0393 Methylobacterium extorquens DM4 hypothetical protein YP_003066110.1 367547 D 661410 CDS YP_003066111.1 254559016 8190847 368481..368801 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 368801 8190847 METDI0394 Methylobacterium extorquens DM4 hypothetical protein YP_003066111.1 368481 D 661410 CDS YP_003066112.1 254559017 8190848 complement(368954..370117) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 370117 8190848 METDI0395 Methylobacterium extorquens DM4 hypothetical protein YP_003066112.1 368954 R 661410 CDS YP_003066113.1 254559018 8190849 complement(370027..370917) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 370917 8190849 METDI0396 Methylobacterium extorquens DM4 hypothetical protein YP_003066113.1 370027 R 661410 CDS YP_003066114.1 254559019 8190850 complement(371059..371400) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 371400 8190850 METDI0397 Methylobacterium extorquens DM4 hypothetical protein YP_003066114.1 371059 R 661410 CDS YP_003066115.1 254559020 8190851 complement(371672..372160) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 372160 8190851 METDI0398 Methylobacterium extorquens DM4 hypothetical protein YP_003066115.1 371672 R 661410 CDS YP_003066116.1 254559021 8190852 372685..373371 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 373371 8190852 METDI0399 Methylobacterium extorquens DM4 hypothetical protein YP_003066116.1 372685 D 661410 CDS YP_003066117.1 254559022 8190853 373641..374003 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 374003 8190853 METDI0400 Methylobacterium extorquens DM4 hypothetical protein YP_003066117.1 373641 D 661410 CDS YP_003066118.1 254559023 8190854 373990..377409 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12620739; Product type pe : putative enzyme; putative ATP-dependent DNA helicase 377409 8190854 METDI0401 Methylobacterium extorquens DM4 putative ATP-dependent DNA helicase YP_003066118.1 373990 D 661410 CDS YP_003066119.1 254559024 8190855 377446..378249 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 378249 8190855 METDI0402 Methylobacterium extorquens DM4 hypothetical protein YP_003066119.1 377446 D 661410 CDS YP_003066120.1 254559025 8190856 378249..379643 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 379643 8190856 METDI0403 Methylobacterium extorquens DM4 hypothetical protein YP_003066120.1 378249 D 661410 CDS YP_003066121.1 254559026 8190857 379640..379981 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 379981 8190857 METDI0404 Methylobacterium extorquens DM4 hypothetical protein YP_003066121.1 379640 D 661410 CDS YP_003066122.1 254559027 8190858 complement(380060..380779) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 380779 8190858 METDI0405 Methylobacterium extorquens DM4 hypothetical protein YP_003066122.1 380060 R 661410 CDS YP_003066123.1 254559028 8190862 complement(382848..383009) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 383009 8190862 METDI0410 Methylobacterium extorquens DM4 hypothetical protein YP_003066123.1 382848 R 661410 CDS YP_003066124.1 254559029 8190863 383292..383573 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 383573 8190863 METDI0411 Methylobacterium extorquens DM4 hypothetical protein YP_003066124.1 383292 D 661410 CDS YP_003066125.1 254559030 8190864 383991..384380 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; PubMedId : 11055911; hypothetical protein 384380 8190864 METDI0412 Methylobacterium extorquens DM4 hypothetical protein YP_003066125.1 383991 D 661410 CDS YP_003066126.1 254559031 8190865 complement(384455..385291) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 385291 8190865 METDI0414 Methylobacterium extorquens DM4 hypothetical protein YP_003066126.1 384455 R 661410 CDS YP_003066127.1 254559032 8190866 complement(385356..385889) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 385889 8190866 METDI0415 Methylobacterium extorquens DM4 hypothetical protein YP_003066127.1 385356 R 661410 CDS YP_003066128.1 254559033 8190867 386043..386375 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 386375 8190867 METDI0416 Methylobacterium extorquens DM4 hypothetical protein YP_003066128.1 386043 D 661410 CDS YP_003066129.1 254559034 8190868 386372..386596 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 386596 8190868 METDI0417 Methylobacterium extorquens DM4 hypothetical protein YP_003066129.1 386372 D 661410 CDS YP_003066130.1 254559035 8190869 386593..387198 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 387198 8190869 METDI0418 Methylobacterium extorquens DM4 hypothetical protein YP_003066130.1 386593 D 661410 CDS YP_003066131.1 254559036 8190870 387198..387485 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 12767982; hypothetical protein 387485 8190870 METDI0419 Methylobacterium extorquens DM4 hypothetical protein YP_003066131.1 387198 D 661410 CDS YP_003066132.1 254559037 8190871 387559..387984 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 387984 8190871 METDI0420 Methylobacterium extorquens DM4 hypothetical protein YP_003066132.1 387559 D 661410 CDS YP_003066133.1 254559038 8190872 388077..388292 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 388292 8190872 METDI0421 Methylobacterium extorquens DM4 hypothetical protein YP_003066133.1 388077 D 661410 CDS YP_003066134.1 254559039 8190873 388421..388846 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 388846 8190873 METDI0422 Methylobacterium extorquens DM4 hypothetical protein YP_003066134.1 388421 D 661410 CDS YP_003066135.1 254559040 8190874 388958..389491 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 389491 8190874 METDI0423 Methylobacterium extorquens DM4 hypothetical protein YP_003066135.1 388958 D 661410 CDS YP_003066136.1 254559041 8190875 389586..390119 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 390119 8190875 METDI0424 Methylobacterium extorquens DM4 hypothetical protein YP_003066136.1 389586 D 661410 CDS YP_003066137.1 254559042 8190876 complement(390116..390700) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative phosphohydrolase/phosphoesterase 390700 8190876 METDI0425 Methylobacterium extorquens DM4 putative phosphohydrolase/phosphoesterase YP_003066137.1 390116 R 661410 CDS YP_003066138.1 254559043 8190877 complement(390794..392215) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type e : enzyme; putative phage integrase, putative integrase/resolvase/recombinase protein, putative DNA integration/recombination/inversion protein 392215 8190877 METDI0426 Methylobacterium extorquens DM4 putative phage integrase, putative integrase/resolvase/recombinase protein, putative DNA integration/recombination/inversion protein YP_003066138.1 390794 R 661410 CDS YP_003066139.1 254559044 8190878 392837..394297 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcriptional regulator, LuxR family 394297 8190878 METDI0427 Methylobacterium extorquens DM4 putative transcriptional regulator, LuxR family YP_003066139.1 392837 D 661410 CDS YP_003066140.1 254559045 8190879 394393..394548 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 10376822, 11988534; hypothetical protein 394548 8190879 METDI0428 Methylobacterium extorquens DM4 hypothetical protein YP_003066140.1 394393 D 661410 CDS YP_003066141.1 254559046 8190880 394607..394948 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 394948 8190880 METDI0429 Methylobacterium extorquens DM4 hypothetical protein YP_003066141.1 394607 D 661410 CDS YP_003066142.1 254559047 8190881 394992..395903 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 395903 8190881 METDI0430 Methylobacterium extorquens DM4 hypothetical protein YP_003066142.1 394992 D 661410 CDS YP_003066143.1 254559048 8190882 395994..396197 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 396197 8190882 METDI0431 Methylobacterium extorquens DM4 hypothetical protein YP_003066143.1 395994 D 661410 CDS YP_003066144.1 254559049 8190883 396272..396655 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 396655 8190883 METDI0432 Methylobacterium extorquens DM4 hypothetical protein YP_003066144.1 396272 D 661410 CDS YP_003066145.1 254559050 8190884 complement(396876..397796) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 397796 8190884 METDI0433 Methylobacterium extorquens DM4 hypothetical protein YP_003066145.1 396876 R 661410 CDS YP_003066146.1 254559051 8190885 complement(397807..398982) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 10684608; Product type e : enzyme; Acetylornithine deacetylase 398982 argE 8190885 argE Methylobacterium extorquens DM4 Acetylornithine deacetylase YP_003066146.1 397807 R 661410 CDS YP_003066147.1 254559052 8195086 complement(398979..399371) 1 NC_012988.1 protein associated with Co2+ and Mg2+ efflux; ApaG 399371 apaG 8195086 apaG Methylobacterium extorquens DM4 ApaG YP_003066147.1 398979 R 661410 CDS YP_003066148.1 254559053 8195076 399539..399988 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 399988 8195076 METDI0436 Methylobacterium extorquens DM4 hypothetical protein YP_003066148.1 399539 D 661410 CDS YP_003066149.1 254559054 8190886 399985..401103 1 NC_012988.1 Catalyzes the deamination of dCTP to form dUTP; 2'-deoxycytidine 5'-triphosphate deaminase 401103 dcd 8190886 dcd Methylobacterium extorquens DM4 2'-deoxycytidine 5'-triphosphate deaminase YP_003066149.1 399985 D 661410 CDS YP_003066150.1 254559055 8195275 complement(401150..402070) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative transport protein 402070 8195275 METDI0438 Methylobacterium extorquens DM4 putative transport protein YP_003066150.1 401150 R 661410 CDS YP_003066151.1 254559056 8190887 complement(402149..402886) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16926146; Product type pf : putative factor; putative Molybdopterin binding, CinA-related 402886 8190887 METDI0439 Methylobacterium extorquens DM4 putative Molybdopterin binding, CinA-related YP_003066151.1 402149 R 661410 CDS YP_003066152.1 254559057 8190888 402970..403716 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 11259647; Product type r : regulator; sugar fermentation stimulation protein 403716 sfsA 8190888 sfsA Methylobacterium extorquens DM4 sugar fermentation stimulation protein YP_003066152.1 402970 D 661410 CDS YP_003066153.1 254559058 8196114 complement(403673..404614) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative Methyltransferase FkbM 404614 8196114 METDI0441 Methylobacterium extorquens DM4 putative Methyltransferase FkbM YP_003066153.1 403673 R 661410 CDS YP_003066154.1 254559059 8190889 404658..405434 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16926146; Product type pe : putative enzyme; putative alpha/beta hydrolase 405434 8190889 METDI0442 Methylobacterium extorquens DM4 putative alpha/beta hydrolase YP_003066154.1 404658 D 661410 CDS YP_003066155.1 254559060 8190890 405573..406037 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 406037 8190890 METDI0443 Methylobacterium extorquens DM4 hypothetical protein YP_003066155.1 405573 D 661410 CDS YP_003066156.1 254559061 8190891 complement(406061..406840) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative ABC-2 transporter, permease 406840 8190891 METDI0444 Methylobacterium extorquens DM4 putative ABC-2 transporter, permease YP_003066156.1 406061 R 661410 CDS YP_003066157.1 254559062 8190892 complement(406837..407763) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16738553, 8202364, 9278503; Product type pt : putative transporter; putative ABC transporter, ATPase 407763 8190892 METDI0445 Methylobacterium extorquens DM4 putative ABC transporter, ATPase YP_003066157.1 406837 R 661410 CDS YP_003066158.1 254559063 8190893 complement(408084..410081) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type pc : putative carrier; 4Fe-4S ferredoxin, iron-sulfur binding 410081 8190893 METDI0446 Methylobacterium extorquens DM4 4Fe-4S ferredoxin, iron-sulfur binding YP_003066158.1 408084 R 661410 CDS YP_003066159.1 254559064 8190894 410264..411022 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 411022 8190894 METDI0447 Methylobacterium extorquens DM4 hypothetical protein YP_003066159.1 410264 D 661410 CDS YP_003066160.1 254559065 8190895 411019..411585 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 411585 8190895 METDI0448 Methylobacterium extorquens DM4 hypothetical protein YP_003066160.1 411019 D 661410 CDS YP_003066161.1 254559066 8190896 411582..412592 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 412592 8190896 METDI0449 Methylobacterium extorquens DM4 hypothetical protein YP_003066161.1 411582 D 661410 CDS YP_003066162.1 254559067 8190897 412601..413119 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 413119 8190897 METDI0450 Methylobacterium extorquens DM4 hypothetical protein YP_003066162.1 412601 D 661410 CDS YP_003066163.1 254559068 8190898 413116..413826 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 413826 8190898 METDI0451 Methylobacterium extorquens DM4 hypothetical protein YP_003066163.1 413116 D 661410 CDS YP_003066164.1 254559069 8190899 413914..414549 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; Cytoplasmic chaperone TorD 414549 8190899 METDI0452 Methylobacterium extorquens DM4 Cytoplasmic chaperone TorD YP_003066164.1 413914 D 661410 CDS YP_003066165.1 254559070 8190900 414623..414871 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; hypothetical protein 414871 8190900 METDI0453 Methylobacterium extorquens DM4 hypothetical protein YP_003066165.1 414623 D 661410 CDS YP_003066166.1 254559071 8190901 414879..417821 1 NC_012988.1 Evidence 1c : Function experimentally demonstrated in the studied genus; Product type e : enzyme; formate dehydrogenase alpha subunit precursor (tat pathway signal) 417821 fdh3A 8190901 fdh3A Methylobacterium extorquens DM4 formate dehydrogenase alpha subunit precursor (tat pathway signal) YP_003066166.1 414879 D 661410 CDS YP_003066167.1 254559072 8195366 417839..418435 1 NC_012988.1 Evidence 1c : Function experimentally demonstrated in the studied genus; Product type e : enzyme; Formate dehydrogenase iron-sulfur (beta) subunit 418435 fdh3B 8195366 fdh3B Methylobacterium extorquens DM4 Formate dehydrogenase iron-sulfur (beta) subunit YP_003066167.1 417839 D 661410 CDS YP_003066168.1 254559073 8195367 418504..419541 1 NC_012988.1 Evidence 1c : Function experimentally demonstrated in the studied genus; Product type e : enzyme; Formate dehydrogenase gamma (cytochrome) subunit 419541 fdh3C 8195367 fdh3C Methylobacterium extorquens DM4 Formate dehydrogenase gamma (cytochrome) subunit YP_003066168.1 418504 D 661410 CDS YP_003066169.1 254559074 8195368 419636..419875 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 419875 8195368 METDI0457 Methylobacterium extorquens DM4 hypothetical protein YP_003066169.1 419636 D 661410 CDS YP_003066170.1 254559075 8190902 419920..420537 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 420537 8190902 METDI0458 Methylobacterium extorquens DM4 hypothetical protein YP_003066170.1 419920 D 661410 CDS YP_003066171.1 254559076 8190903 complement(420575..421168) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 421168 8190903 METDI0459 Methylobacterium extorquens DM4 hypothetical protein YP_003066171.1 420575 R 661410 CDS YP_003066172.1 254559077 8190904 421488..421802 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 421802 8190904 METDI0460 Methylobacterium extorquens DM4 hypothetical protein YP_003066172.1 421488 D 661410 CDS YP_003066173.1 254559078 8190905 421799..422434 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative TetR family transcriptional regulatory protein 422434 8190905 METDI0461 Methylobacterium extorquens DM4 putative TetR family transcriptional regulatory protein YP_003066173.1 421799 D 661410 CDS YP_003066174.1 254559079 8190906 422431..423672 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative HlyD family secretion protein precursor; putative efflux transporter, membrane fusion protein subunit precursor 423672 8190906 METDI0462 Methylobacterium extorquens DM4 putative HlyD family secretion protein precursor; putative efflux transporter, membrane fusion protein subunit precursor YP_003066174.1 422431 D 661410 CDS YP_003066175.1 254559080 8190907 423721..426816 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type t : transporter; efflux transporter (AcrB/AcrD/AcrF family multidrug efflux pump 426816 8190907 METDI0463 Methylobacterium extorquens DM4 efflux transporter (AcrB/AcrD/AcrF family multidrug efflux pump YP_003066175.1 423721 D 661410 CDS YP_003066176.1 254559081 8190908 complement(427069..427347) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 427347 8190908 METDI0464 Methylobacterium extorquens DM4 hypothetical protein YP_003066176.1 427069 R 661410 CDS YP_003066177.1 254559082 8190909 complement(427476..428579) 1 NC_012988.1 Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons; heat-inducible transcription repressor 428579 hrcA 8190909 hrcA Methylobacterium extorquens DM4 heat-inducible transcription repressor YP_003066177.1 427476 R 661410 CDS YP_003066178.1 254559083 8195576 428845..429108 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 429108 8195576 METDI0466 Methylobacterium extorquens DM4 hypothetical protein YP_003066178.1 428845 D 661410 CDS YP_003066179.1 254559084 8190910 429026..429232 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 429232 8190910 METDI0467 Methylobacterium extorquens DM4 hypothetical protein YP_003066179.1 429026 D 661410 CDS YP_003066180.1 254559085 8190911 429273..429986 1 NC_012988.1 RNase PH; tRNA nucleotidyltransferase; forms hexamers in Bacillus subtilis; phosphoroltic 3'-5' exoribonuclease; involved in maturation of tRNA precursors and removes terminal nucleotides near CCA acceptor arms of mature tRNAs; ribonuclease PH 429986 rph 8190911 rph Methylobacterium extorquens DM4 ribonuclease PH YP_003066180.1 429273 D 661410 CDS YP_003066181.1 254559086 8196010 429983..430618 1 NC_012988.1 HAM1-like protein; Rec-dependent growth; RgdB; yggV; it is suspected that this protein functions to remove misincorporated bases such as xanthine or hypoxanthine; putative deoxyribonucleotide triphosphate pyrophosphatase 430618 8196010 METDI0469 Methylobacterium extorquens DM4 putative deoxyribonucleotide triphosphate pyrophosphatase YP_003066181.1 429983 D 661410 CDS YP_003066182.1 254559087 8190912 430868..432046 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative oxidase 432046 yggW 8190912 yggW Methylobacterium extorquens DM4 putative oxidase YP_003066182.1 430868 D 661410 CDS YP_003066183.1 254559088 8196366 432102..432335 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 432335 8196366 METDI0471 Methylobacterium extorquens DM4 hypothetical protein YP_003066183.1 432102 D 661410 CDS YP_003066184.1 254559089 8190913 432332..432619 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 432619 8190913 METDI0472 Methylobacterium extorquens DM4 hypothetical protein YP_003066184.1 432332 D 661410 CDS YP_003066185.1 254559090 8190914 complement(432641..433852) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type prc : putative receptor; putative extracellular ligand-binding receptor precursor 433852 8190914 METDI0473 Methylobacterium extorquens DM4 putative extracellular ligand-binding receptor precursor YP_003066185.1 432641 R 661410 CDS YP_003066186.1 254559091 8190915 433973..434923 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative methyltransferase 434923 yraL 8190915 yraL Methylobacterium extorquens DM4 putative methyltransferase YP_003066186.1 433973 D 661410 CDS YP_003066187.1 254559092 8196378 434907..435293 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 435293 8196378 METDI0475 Methylobacterium extorquens DM4 hypothetical protein YP_003066187.1 434907 D 661410 CDS YP_003066188.1 254559093 8190916 complement(435323..435712) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative response regulator receiver 435712 8190916 METDI0476 Methylobacterium extorquens DM4 putative response regulator receiver YP_003066188.1 435323 R 661410 CDS YP_003066189.1 254559094 8190917 436005..436916 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 15251200; Product type t : transporter; ABC transporter, periplasmic protein, putative glycine/betaine transporter 436916 8190917 METDI0477 Methylobacterium extorquens DM4 ABC transporter, periplasmic protein, putative glycine/betaine transporter YP_003066189.1 436005 D 661410 CDS YP_003066190.1 254559095 8190918 436913..438055 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type t : transporter; ABC transporter, permease, putative glycine/betaine transporter 438055 8190918 METDI0478 Methylobacterium extorquens DM4 ABC transporter, permease, putative glycine/betaine transporter YP_003066190.1 436913 D 661410 CDS YP_003066191.1 254559096 8190919 438052..438780 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type t : transporter; ABC transporter, permease, putative glycine/betaine transporter 438780 8190919 METDI0479 Methylobacterium extorquens DM4 ABC transporter, permease, putative glycine/betaine transporter YP_003066191.1 438052 D 661410 CDS YP_003066192.1 254559097 8190920 complement(438787..439881) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; ErfK/YbiS/YcfS/YnhG family protein 439881 8190920 METDI0480 Methylobacterium extorquens DM4 ErfK/YbiS/YcfS/YnhG family protein YP_003066192.1 438787 R 661410 CDS YP_003066193.1 254559098 8190921 complement(440003..440920) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 440920 8190921 METDI0481 Methylobacterium extorquens DM4 hypothetical protein YP_003066193.1 440003 R 661410 CDS YP_003066194.1 254559099 8190922 441118..443217 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; Peptidyl-dipeptidase 443217 dcp 8190922 dcp Methylobacterium extorquens DM4 Peptidyl-dipeptidase YP_003066194.1 441118 D 661410 CDS YP_003066195.1 254559100 8195278 complement(443332..445005) 1 NC_012988.1 Evidence 1c : Function experimentally demonstrated in the studied genus; PubMedId : 14645277; Product type e : enzyme; formate-tetrahydrofolate ligase (formyltetrahydrofolate synthetase) (FHS) (FTHFS) 445005 ftfL 8195278 ftfL Methylobacterium extorquens DM4 formate-tetrahydrofolate ligase (formyltetrahydrofolate synthetase) (FHS) (FTHFS) YP_003066195.1 443332 R 661410 CDS YP_003066196.1 254559101 8195446 complement(445244..445465) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12644235; Product type pc : putative carrier; putative copper ion binding protein; putative heavy metal transport/detoxification protein 445465 8195446 METDI0484 Methylobacterium extorquens DM4 putative copper ion binding protein; putative heavy metal transport/detoxification protein YP_003066196.1 445244 R 661410 CDS YP_003066197.1 254559102 8190923 445752..447233 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 447233 8190923 METDI0485 Methylobacterium extorquens DM4 hypothetical protein YP_003066197.1 445752 D 661410 CDS YP_003066198.1 254559103 8190924 complement(447268..447495) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 447495 8190924 METDI0486 Methylobacterium extorquens DM4 hypothetical protein YP_003066198.1 447268 R 661410 CDS YP_003066199.1 254559104 8190925 complement(447666..448202) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 448202 8190925 METDI0487 Methylobacterium extorquens DM4 hypothetical protein YP_003066199.1 447666 R 661410 CDS YP_003066200.1 254559105 8190926 448181..448420 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 448420 8190926 METDI0488 Methylobacterium extorquens DM4 hypothetical protein YP_003066200.1 448181 D 661410 CDS YP_003066201.1 254559106 8190927 complement(448386..448769) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative response regulator receiver (CheY-like protein) 448769 8190927 METDI0489 Methylobacterium extorquens DM4 putative response regulator receiver (CheY-like protein) YP_003066201.1 448386 R 661410 CDS YP_003066202.1 254559107 8190928 449076..450089 1 NC_012988.1 [Includes: Riboflavin kinase (Flavokinase); FMN adenylyltransferase (FAD pyrophosphorylase) (FAD synthetase)]; Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 2985604, 9743119; Product type pe : putative enzyme; putative riboflavin biosynthesis protein ribF 450089 ribF 8190928 ribF Methylobacterium extorquens DM4 putative riboflavin biosynthesis protein ribF YP_003066202.1 449076 D 661410 CDS YP_003066203.1 254559108 8195996 complement(450280..451284) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative 2-hydroxyacid dehydrogenase 451284 8195996 METDI0491 Methylobacterium extorquens DM4 putative 2-hydroxyacid dehydrogenase YP_003066203.1 450280 R 661410 CDS YP_003066204.1 254559109 8190929 451610..452203 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 452203 8190929 METDI0492 Methylobacterium extorquens DM4 hypothetical protein YP_003066204.1 451610 D 661410 CDS YP_003066205.1 254559110 8190930 complement(452308..452808) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type r : regulator; Ferric uptake regulator family, Irr-like protein 452808 8190930 METDI0493 Methylobacterium extorquens DM4 Ferric uptake regulator family, Irr-like protein YP_003066205.1 452308 R 661410 CDS YP_003066206.1 254559111 8190931 453085..453624 1 NC_012988.1 catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to 2,3-decenoyl-ACP or 3,4-decenoyl-ACP; 3-hydroxydecanoyl-(acyl carrier protein) dehydratase 453624 fabA 8190931 fabA Methylobacterium extorquens DM4 3-hydroxydecanoyl-(acyl carrier protein) dehydratase YP_003066206.1 453085 D 661410 CDS YP_003066207.1 254559112 8195341 453785..455011 1 NC_012988.1 FabB, beta-Ketoacyl-ACP synthase I, KASI; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP; 3-oxoacyl-(acyl carrier protein) synthase I 455011 fabB 8195341 fabB Methylobacterium extorquens DM4 3-oxoacyl-(acyl carrier protein) synthase I YP_003066207.1 453785 D 661410 CDS YP_003066208.1 254559113 8195342 455165..455284 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 455284 8195342 METDI0496 Methylobacterium extorquens DM4 hypothetical protein YP_003066208.1 455165 D 661410 CDS YP_003066209.1 254559114 8190932 455485..456315 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 10398587, 2687243; Product type e : enzyme; Enoyl-[acyl-carrier-protein] reductase (NADH) 456315 fabI 8190932 fabI Methylobacterium extorquens DM4 Enoyl-[acyl-carrier-protein] reductase (NADH) YP_003066209.1 455485 D 661410 CDS YP_003066210.1 254559115 8195348 456383..457144 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type s : structure; flagellar biosynthesis protein FliP 457144 fliP 8195348 fliP Methylobacterium extorquens DM4 flagellar biosynthesis protein FliP YP_003066210.1 456383 D 661410 CDS YP_003066211.1 254559116 8195426 457201..457602 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 457602 8195426 METDI0499 Methylobacterium extorquens DM4 hypothetical protein YP_003066211.1 457201 D 661410 CDS YP_003066212.1 254559117 8190933 complement(457606..460956) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 460956 8190933 METDI0500 Methylobacterium extorquens DM4 hypothetical protein YP_003066212.1 457606 R 661410 CDS YP_003066213.1 254559118 8190934 complement(461072..461503) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 461503 8190934 METDI0501 Methylobacterium extorquens DM4 hypothetical protein YP_003066213.1 461072 R 661410 CDS YP_003066214.1 254559119 8190935 complement(461657..463804) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; Peptidase S9, prolyl oligopeptidase 463804 8190935 METDI0502 Methylobacterium extorquens DM4 Peptidase S9, prolyl oligopeptidase YP_003066214.1 461657 R 661410 CDS YP_003066215.1 254559120 8190936 464233..464670 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 10656595, 11481430, 7756693; Product type r : regulator; Transcriptional regulatory protein mucR 464670 mucR 8190936 mucR Methylobacterium extorquens DM4 Transcriptional regulatory protein mucR YP_003066215.1 464233 D 661410 CDS YP_003066216.1 254559121 8195735 464821..465015 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 465015 8195735 METDI0504 Methylobacterium extorquens DM4 hypothetical protein YP_003066216.1 464821 D 661410 CDS YP_003066217.1 254559122 8190937 465152..465976 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 465976 8190937 METDI0505 Methylobacterium extorquens DM4 hypothetical protein YP_003066217.1 465152 D 661410 CDS YP_003066218.1 254559123 8190938 complement(466014..466442) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier; putative sulfur acceptor protein sufE 466442 8190938 METDI0506 Methylobacterium extorquens DM4 putative sulfur acceptor protein sufE YP_003066218.1 466014 R 661410 CDS YP_003066219.1 254559124 8190939 complement(466531..467610) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 467610 8190939 METDI0507 Methylobacterium extorquens DM4 hypothetical protein YP_003066219.1 466531 R 661410 CDS YP_003066220.1 254559125 8190940 complement(467763..471431) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative sensor hybrid histidine kinase with multiple PAS/PAC, GAF and response regulator receiver domains 471431 8190940 METDI0508 Methylobacterium extorquens DM4 putative sensor hybrid histidine kinase with multiple PAS/PAC, GAF and response regulator receiver domains YP_003066220.1 467763 R 661410 CDS YP_003066221.1 254559126 8190941 472118..472627 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 472627 8190941 METDI0509 Methylobacterium extorquens DM4 hypothetical protein YP_003066221.1 472118 D 661410 CDS YP_003066222.1 254559127 8190942 472743..472907 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 472907 8190942 METDI0510 Methylobacterium extorquens DM4 hypothetical protein YP_003066222.1 472743 D 661410 CDS YP_003066223.1 254559128 8190943 complement(472954..473376) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10882093; Product type pe : putative enzyme; putative lactoylglutathione lyase 473376 8190943 METDI0511 Methylobacterium extorquens DM4 putative lactoylglutathione lyase YP_003066223.1 472954 R 661410 CDS YP_003066224.1 254559129 8190944 473817..474725 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 474725 8190944 METDI0512 Methylobacterium extorquens DM4 hypothetical protein YP_003066224.1 473817 D 661410 CDS YP_003066225.1 254559130 8190945 474804..477440 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; aminopeptidase N 477440 pepN 8190945 pepN Methylobacterium extorquens DM4 aminopeptidase N YP_003066225.1 474804 D 661410 CDS YP_003066226.1 254559131 8195844 477626..479986 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative PAS sensor signal transduction histidine kinase 479986 8195844 METDI0514 Methylobacterium extorquens DM4 putative PAS sensor signal transduction histidine kinase YP_003066226.1 477626 D 661410 CDS YP_003066227.1 254559132 8190946 480393..481319 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 2806247, 7540694, 9375792; Product type e : enzyme; arginase (arginine amidinase) 481319 rocF 8190946 rocF Methylobacterium extorquens DM4 arginase (arginine amidinase) YP_003066227.1 480393 D 661410 CDS YP_003066228.1 254559133 8196008 complement(481412..482890) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 17631881, 9537370; Product type e : enzyme; Glucose-6-phosphate 1-dehydrogenase (G6PD) 482890 zwf 8196008 zwf Methylobacterium extorquens DM4 Glucose-6-phosphate 1-dehydrogenase (G6PD) YP_003066228.1 481412 R 661410 CDS YP_003066229.1 254559134 8196381 complement(483161..483598) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 483598 8196381 METDI0518 Methylobacterium extorquens DM4 hypothetical protein YP_003066229.1 483161 R 661410 CDS YP_003066230.1 254559135 8190947 complement(484230..484553) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 7623666, 7623667, 95349397; Product type pf : putative factor; copper binding protein, copper sensitivity 484553 cutA 8190947 cutA Methylobacterium extorquens DM4 copper binding protein, copper sensitivity YP_003066230.1 484230 R 661410 CDS YP_003066231.1 254559136 8195232 484659..485429 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11259647; Product type pe : putative enzyme; putative inorganic polyphosphate/ATP-NAD kinase (Poly(P)/ATP NAD kinase) 485429 ppnK 8195232 ppnK Methylobacterium extorquens DM4 putative inorganic polyphosphate/ATP-NAD kinase (Poly(P)/ATP NAD kinase) YP_003066231.1 484659 D 661410 CDS YP_003066232.1 254559137 8195885 complement(485498..485725) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 485725 8195885 METDI0521 Methylobacterium extorquens DM4 hypothetical protein YP_003066232.1 485498 R 661410 CDS YP_003066233.1 254559138 8190948 485815..487179 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 14656444, 8412700, 8432722, 9086272, 99212225; Product type e : enzyme; 16S rRNA m5C967 methyltransferase, S-adenosyl-L-methionine-dependent 487179 rsmB 8190948 rsmB Methylobacterium extorquens DM4 16S rRNA m5C967 methyltransferase, S-adenosyl-L-methionine-dependent YP_003066233.1 485815 D 661410 CDS YP_003066234.1 254559139 8196089 complement(487239..487403) 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 487403 8196089 METDI0523 Methylobacterium extorquens DM4 hypothetical protein YP_003066234.1 487239 R 661410 CDS YP_003066235.1 254559140 8190949 487750..488784 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 488784 8190949 METDI0524 Methylobacterium extorquens DM4 hypothetical protein YP_003066235.1 487750 D 661410 CDS YP_003066236.1 254559141 8190950 489158..490351 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative 2-amino-3-ketobutyrate coenzyme A ligase (AKB ligase) (Glycine acetyltransferase) 490351 8190950 METDI0525 Methylobacterium extorquens DM4 putative 2-amino-3-ketobutyrate coenzyme A ligase (AKB ligase) (Glycine acetyltransferase) YP_003066236.1 489158 D 661410 CDS YP_003066237.1 254559142 8190951 complement(490412..490741) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 490741 8190951 METDI0526 Methylobacterium extorquens DM4 hypothetical protein YP_003066237.1 490412 R 661410 CDS YP_003066238.1 254559143 8190952 491087..492019 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 7768883; Product type e : enzyme; malonyl-CoA-[acyl-carrier-protein] transacylase 492019 fabD 8190952 fabD Methylobacterium extorquens DM4 malonyl-CoA-[acyl-carrier-protein] transacylase YP_003066238.1 491087 D 661410 CDS YP_003066239.1 254559144 8195343 492128..492868 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 11669613, 1314802; Product type e : enzyme; 3-oxoacyl-[acyl-carrier-protein] reductase 492868 fabG 8195343 fabG Methylobacterium extorquens DM4 3-oxoacyl-[acyl-carrier-protein] reductase YP_003066239.1 492128 D 661410 CDS YP_003066240.1 254559145 8195345 493132..493368 1 NC_012988.1 carries the fatty acid chain in fatty acid biosynthesis; acyl carrier protein 493368 acpP 8195345 acpP Methylobacterium extorquens DM4 acyl carrier protein YP_003066240.1 493132 D 661410 CDS YP_003066241.1 254559146 8195050 493537..494769 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 9013860, 9482715; Product type e : enzyme; 3-oxoacyl-[acyl-carrier-protein] synthase II 494769 fabF 8195050 fabF Methylobacterium extorquens DM4 3-oxoacyl-[acyl-carrier-protein] synthase II YP_003066241.1 493537 D 661410 CDS YP_003066242.1 254559147 8195344 495032..496435 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 496435 8195344 METDI0532 Methylobacterium extorquens DM4 hypothetical protein YP_003066242.1 495032 D 661410 CDS YP_003066243.1 254559148 8190953 complement(496465..497181) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative haloacid dehalogenase-like hydrolase 497181 8190953 METDI0533 Methylobacterium extorquens DM4 putative haloacid dehalogenase-like hydrolase YP_003066243.1 496465 R 661410 CDS YP_003066244.1 254559149 8190954 complement(497195..499582) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type e : enzyme; putative glycoside hydrolase or sugar phosphorilase 499582 8190954 METDI0534 Methylobacterium extorquens DM4 putative glycoside hydrolase or sugar phosphorilase YP_003066244.1 497195 R 661410 CDS YP_003066245.1 254559150 8190955 500447..501649 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative acetate kinase (ackA) 501649 8190955 METDI0535 Methylobacterium extorquens DM4 putative acetate kinase (ackA) YP_003066245.1 500447 D 661410 CDS YP_003066246.1 254559151 8190956 501646..502677 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; putative membrane protein, component of efflux system 502677 8190956 METDI0536 Methylobacterium extorquens DM4 putative membrane protein, component of efflux system YP_003066246.1 501646 D 661410 CDS YP_003066247.1 254559152 8190957 502685..505423 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative ABC transporter, fused tandem ATPase and permease domains 505423 8190957 METDI0537 Methylobacterium extorquens DM4 putative ABC transporter, fused tandem ATPase and permease domains YP_003066247.1 502685 D 661410 CDS YP_003066248.1 254559153 8190958 505425..506624 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; putative ABC-2 transporter, permease 506624 8190958 METDI0538 Methylobacterium extorquens DM4 putative ABC-2 transporter, permease YP_003066248.1 505425 D 661410 CDS YP_003066249.1 254559154 8190959 506704..509139 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 11292814, 11823225; Product type e : enzyme; putative phosphoketolase 509139 xfp 8190959 xfp Methylobacterium extorquens DM4 putative phosphoketolase YP_003066249.1 506704 D 661410 CDS YP_003066250.1 254559155 8196340 509263..510393 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 11756688; Product type e : enzyme; Salicylate hydroxylase (Salicylate 1-monooxygenase) 510393 8196340 METDI0540 Methylobacterium extorquens DM4 Salicylate hydroxylase (Salicylate 1-monooxygenase) YP_003066250.1 509263 D 661410 CDS YP_003066251.1 254559156 8196227 510804..511862 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 2188958, 7665461, 90202710, 90264334; Product type pt : putative transporter; putative sulfate/thiosulfate transporter subunit ; ATP-binding component of ABC superfamily 511862 cysA 8196227 cysA Methylobacterium extorquens DM4 putative sulfate/thiosulfate transporter subunit ; ATP-binding component of ABC superfamily YP_003066251.1 510804 D 661410 CDS YP_003066252.1 254559157 8195248 511965..512990 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 16926146; Product type t : transporter; ABC transporter, periplasmic protein precursor, putative iron transporter 512990 fbpA 8195248 fbpA Methylobacterium extorquens DM4 ABC transporter, periplasmic protein precursor, putative iron transporter YP_003066252.1 511965 D 661410 CDS YP_003066253.1 254559158 8195357 513067..514719 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 9884235; Product type t : transporter; ABC transporter, permease precursor, putative iron transporter 514719 fpbB 8195357 fpbB Methylobacterium extorquens DM4 ABC transporter, permease precursor, putative iron transporter YP_003066253.1 513067 D 661410 CDS YP_003066254.1 254559159 8195440 complement(514727..514828) 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 514828 8195440 METDI0544 Methylobacterium extorquens DM4 hypothetical protein YP_003066254.1 514727 R 661410 CDS YP_003066255.1 254559160 8190961 complement(515142..515396) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 515396 8190961 METDI0545 Methylobacterium extorquens DM4 hypothetical protein YP_003066255.1 515142 R 661410 CDS YP_003066256.1 254559161 8190962 complement(515680..516378) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 516378 8190962 METDI0546 Methylobacterium extorquens DM4 hypothetical protein YP_003066256.1 515680 R 661410 CDS YP_003066257.1 254559162 8190963 516565..517530 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 517530 8190963 METDI0547 Methylobacterium extorquens DM4 hypothetical protein YP_003066257.1 516565 D 661410 CDS YP_003066258.1 254559163 8190964 517618..518946 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative flavin containing amine oxidase 518946 8190964 METDI0548 Methylobacterium extorquens DM4 putative flavin containing amine oxidase YP_003066258.1 517618 D 661410 CDS YP_003066259.1 254559164 8190965 519055..519690 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative cyclic nucleotide-binding domain 519690 8190965 METDI0549 Methylobacterium extorquens DM4 putative cyclic nucleotide-binding domain YP_003066259.1 519055 D 661410 CDS YP_003066260.1 254559165 8190966 complement(519694..520113) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 520113 8190966 METDI0550 Methylobacterium extorquens DM4 hypothetical protein YP_003066260.1 519694 R 661410 CDS YP_003066261.1 254559166 8190967 520318..520524 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 520524 8190967 METDI0551 Methylobacterium extorquens DM4 hypothetical protein YP_003066261.1 520318 D 661410 CDS YP_003066262.1 254559167 8190968 complement(520684..520797) 1 NC_012988.1 Evidence 6 : Doubtful CDS; Product type n : RNA; hypothetical protein 520797 8190968 METDI0552 Methylobacterium extorquens DM4 hypothetical protein YP_003066262.1 520684 R 661410 CDS YP_003066263.1 254559168 8190969 complement(520951..521241) 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 521241 8190969 METDI0553 Methylobacterium extorquens DM4 hypothetical protein YP_003066263.1 520951 R 661410 CDS YP_003066264.1 254559169 8190970 521894..522943 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 15188393, 16926146; Product type t : transporter; ABC transporter, periplasmic protein, putative sulfate/thiosulfate transporter 522943 cysP 8190970 cysP Methylobacterium extorquens DM4 ABC transporter, periplasmic protein, putative sulfate/thiosulfate transporter YP_003066264.1 521894 D 661410 CDS YP_003066265.1 254559170 8195260 522948..523802 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 2188958; Product type t : transporter; ABC transporter, permease, putative sulfate/thiosulfate transporter 523802 cysU 8195260 cysU Methylobacterium extorquens DM4 ABC transporter, permease, putative sulfate/thiosulfate transporter YP_003066265.1 522948 D 661410 CDS YP_003066266.1 254559171 8195262 523807..524697 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 2188958; Product type t : transporter; ABC transporter, permease, putative sulfate/thiosulfate transporter 524697 cysW 8195262 cysW Methylobacterium extorquens DM4 ABC transporter, permease, putative sulfate/thiosulfate transporter YP_003066266.1 523807 D 661410 CDS YP_003066267.1 254559172 8195263 524702..525745 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 2188958; Product type t : transporter; ABC transporter, ATPase, putative sulfate/thiosulfate transporter 525745 cysA 8195263 cysA Methylobacterium extorquens DM4 ABC transporter, ATPase, putative sulfate/thiosulfate transporter YP_003066267.1 524702 D 661410 CDS YP_003066268.1 254559173 8196084 complement(532146..532616) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 532616 8196084 METDI0563 Methylobacterium extorquens DM4 hypothetical protein YP_003066268.1 532146 R 661410 CDS YP_003066269.1 254559174 8190971 532799..533500 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 2669955; Product type e : enzyme; endonuclease III DNA glycosylase/apyrimidinic (AP) lyase 533500 nth 8190971 nth Methylobacterium extorquens DM4 endonuclease III DNA glycosylase/apyrimidinic (AP) lyase YP_003066269.1 532799 D 661410 CDS YP_003066270.1 254559175 8195784 533694..534488 1 NC_012988.1 catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis; SAICAR synthase; phosphoribosylaminoimidazole-succinocarboxamide synthase 534488 purC 8195784 purC Methylobacterium extorquens DM4 phosphoribosylaminoimidazole-succinocarboxamide synthase YP_003066270.1 533694 D 661410 CDS YP_003066271.1 254559176 8195931 complement(534496..536151) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 536151 8195931 METDI0566 Methylobacterium extorquens DM4 hypothetical protein YP_003066271.1 534496 R 661410 CDS YP_003066272.1 254559177 8190972 complement(536148..538202) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8626291; Product type pe : putative enzyme; putative glycosyl transferase 538202 8190972 METDI0567 Methylobacterium extorquens DM4 putative glycosyl transferase YP_003066272.1 536148 R 661410 CDS YP_003066273.1 254559178 8190973 complement(538261..538851) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 538851 8190973 METDI0568 Methylobacterium extorquens DM4 hypothetical protein YP_003066273.1 538261 R 661410 CDS YP_003066274.1 254559179 8190974 complement(538954..539496) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 539496 8190974 METDI0569 Methylobacterium extorquens DM4 hypothetical protein YP_003066274.1 538954 R 661410 CDS YP_003066275.1 254559180 8190975 539733..540152 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 540152 8190975 METDI0570 Methylobacterium extorquens DM4 hypothetical protein YP_003066275.1 539733 D 661410 CDS YP_003066276.1 254559181 8190976 complement(540239..540964) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative metal-dependent hydrolase 540964 8190976 METDI0571 Methylobacterium extorquens DM4 putative metal-dependent hydrolase YP_003066276.1 540239 R 661410 CDS YP_003066277.1 254559182 8190977 complement(541060..542304) 1 NC_012988.1 Evidence 1c : Function experimentally demonstrated in the studied genus; Product type e : enzyme; intracellular PHB depolymerase 542304 depA 8190977 depA Methylobacterium extorquens DM4 intracellular PHB depolymerase YP_003066277.1 541060 R 661410 CDS YP_003066278.1 254559183 8195289 542450..543844 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 9683482; Product type e : enzyme; two component sensor histidine kinase, RegS 543844 regS 8195289 regS Methylobacterium extorquens DM4 two component sensor histidine kinase, RegS YP_003066278.1 542450 D 661410 CDS YP_003066279.1 254559184 8195977 543881..544483 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 9683482; Product type r : regulator; two-component transcriptional regulator RegR, Fis family 544483 regR 8195977 regR Methylobacterium extorquens DM4 two-component transcriptional regulator RegR, Fis family YP_003066279.1 543881 D 661410 CDS YP_003066280.1 254559185 8195976 544665..544889 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 544889 8195976 METDI0575 Methylobacterium extorquens DM4 hypothetical protein YP_003066280.1 544665 D 661410 CDS YP_003066281.1 254559186 8190978 545081..545320 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 10784038; Product type pf : putative factor; Phosphoribosylformylglycinamidine synthetase PurS 545320 yexA 8190978 yexA Methylobacterium extorquens DM4 Phosphoribosylformylglycinamidine synthetase PurS YP_003066281.1 545081 D 661410 CDS YP_003066282.1 254559187 8196363 545320..546000 1 NC_012988.1 catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis; phosphoribosylformylglycinamidine synthase I 546000 purQ 8196363 purQ Methylobacterium extorquens DM4 phosphoribosylformylglycinamidine synthase I YP_003066282.1 545320 D 661410 CDS YP_003066283.1 254559188 8195940 complement(546126..546671) 1 NC_012988.1 catalyzes a salvage reaction resulting in the formation of AMP which is metabolically less costly than a de novo synthesis; adenine phosphoribosyltransferase 546671 apt 8195940 apt Methylobacterium extorquens DM4 adenine phosphoribosyltransferase YP_003066283.1 546126 R 661410 CDS YP_003066284.1 254559189 8195077 complement(546754..547548) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 10747806, 8002619; Product type e : enzyme; inositol monophosphatase 547548 suhB 8195077 suhB Methylobacterium extorquens DM4 inositol monophosphatase YP_003066284.1 546754 R 661410 CDS YP_003066285.1 254559190 8196175 complement(547832..548449) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; thiamine-phosphate pyrophosphorylase (TMP pyrophosphorylase) (TMP-PPase) (thiamine-phosphate synthase) 548449 thiE 8196175 thiE Methylobacterium extorquens DM4 thiamine-phosphate pyrophosphorylase (TMP pyrophosphorylase) (TMP-PPase) (thiamine-phosphate synthase) YP_003066285.1 547832 R 661410 CDS YP_003066286.1 254559191 8196187 complement(548456..549277) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; thiazole synthase 549277 thiG 8196187 thiG Methylobacterium extorquens DM4 thiazole synthase YP_003066286.1 548456 R 661410 CDS YP_003066287.1 254559192 8196189 complement(549280..549492) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type f : factor; thiamin biosynthesis proteinsulfur carrier) ThiS 549492 thiS 8196189 thiS Methylobacterium extorquens DM4 thiamin biosynthesis proteinsulfur carrier) ThiS YP_003066287.1 549280 R 661410 CDS YP_003066288.1 254559193 8196192 complement(549489..550724) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; glycine oxidase 550724 thiO 8196192 thiO Methylobacterium extorquens DM4 glycine oxidase YP_003066288.1 549489 R 661410 CDS YP_003066289.1 254559194 8195038 complement(551048..552322) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative Adenylate/Guanylate cyclase 552322 8195038 METDI0585 Methylobacterium extorquens DM4 putative Adenylate/Guanylate cyclase YP_003066289.1 551048 R 661410 CDS YP_003066290.1 254559195 8190979 552619..552987 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 552987 8190979 METDI0586 Methylobacterium extorquens DM4 hypothetical protein YP_003066290.1 552619 D 661410 CDS YP_003066291.1 254559196 8190980 553279..554283 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 554283 8190980 METDI0587 Methylobacterium extorquens DM4 hypothetical protein YP_003066291.1 553279 D 661410 CDS YP_003066292.1 254559197 8190981 554292..555635 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 7592429; Product type pt : putative transporter; major facilitator superfamily (MFS_1) transporter ( putative tartrate transporter, ttuB) 555635 8190981 METDI0588 Methylobacterium extorquens DM4 major facilitator superfamily (MFS_1) transporter ( putative tartrate transporter, ttuB) YP_003066292.1 554292 D 661410 CDS YP_003066293.1 254559198 8190982 complement(555680..557680) 1 NC_012988.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this is the primary sigma factor of bacteria; RNA polymerase sigma factor RpoD 557680 rpoD 8190982 rpoD Methylobacterium extorquens DM4 RNA polymerase sigma factor RpoD YP_003066293.1 555680 R 661410 CDS YP_003066294.1 254559199 8196047 complement(557882..559807) 1 NC_012988.1 synthesizes RNA primers at the replication forks; DNA primase 559807 dnaG 8196047 dnaG Methylobacterium extorquens DM4 DNA primase YP_003066294.1 557882 R 661410 CDS YP_003066295.1 254559200 8195306 559942..560928 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; Gluconolactonase (D-glucono-delta-lactone lactonohydrolase) 560928 gnl 8195306 gnl Methylobacterium extorquens DM4 Gluconolactonase (D-glucono-delta-lactone lactonohydrolase) YP_003066295.1 559942 D 661410 CDS YP_003066296.1 254559201 8195525 560925..562091 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 562091 8195525 METDI0592 Methylobacterium extorquens DM4 hypothetical protein YP_003066296.1 560925 D 661410 CDS YP_003066297.1 254559202 8190983 complement(562280..562738) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B (Asp/Glu-ADT subunit B) 562738 gatB 8190983 gatB Methylobacterium extorquens DM4 Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B (Asp/Glu-ADT subunit B) YP_003066297.1 562280 R 661410 CDS YP_003066298.1 254559203 8195469 562928..564178 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type e : enzyme; carbamoyl phosphate synthetase, glutamine amidotransferase small subunit 564178 carA 8195469 carA Methylobacterium extorquens DM4 carbamoyl phosphate synthetase, glutamine amidotransferase small subunit YP_003066298.1 562928 D 661410 CDS YP_003066299.1 254559204 8195146 564318..564692 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 564692 8195146 METDI0595 Methylobacterium extorquens DM4 hypothetical protein YP_003066299.1 564318 D 661410 CDS YP_003066300.1 254559205 8190984 complement(564733..567393) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 567393 8190984 METDI0596 Methylobacterium extorquens DM4 hypothetical protein YP_003066300.1 564733 R 661410 CDS YP_003066301.1 254559206 8190985 567551..567940 1 NC_012988.1 with FlgF and C makes up the proximal portion of the flagellar basal body rod; Bradyrhizobium have one thick flagellum and several thin flagella; the proteins in this cluster are associated with the thin flagella; flagellar basal body rod protein FlgB 567940 flgB 8190985 flgB Methylobacterium extorquens DM4 flagellar basal body rod protein FlgB YP_003066301.1 567551 D 661410 CDS YP_003066302.1 254559207 8195391 567937..568353 1 NC_012988.1 with FlgF and B makes up the proximal portion of the flagellar basal body rod; Bradyrhizobium have one thick flagellum and several thin flagella; the protein in this cluster is associated with the thin flagella; flagellar basal body rod protein FlgC 568353 flgC 8195391 flgC Methylobacterium extorquens DM4 flagellar basal body rod protein FlgC YP_003066302.1 567937 D 661410 CDS YP_003066303.1 254559208 8195393 568367..568720 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type s : structure; Flagellar hook-basal body complex protein FliE 568720 fliE 8195393 fliE Methylobacterium extorquens DM4 Flagellar hook-basal body complex protein FliE YP_003066303.1 568367 D 661410 CDS YP_003066304.1 254559209 8195413 568813..569601 1 NC_012988.1 makes up the distal portion of the flagellar basal body rod; Bradyrhizobium has one thick flagellum and several thin flagella; the protein in this cluster is associated with the thin flagella; flagellar basal body rod protein FlgG 569601 flgG 8195413 flgG Methylobacterium extorquens DM4 flagellar basal body rod protein FlgG YP_003066304.1 568813 D 661410 CDS YP_003066305.1 254559210 8195400 569667..570161 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type s : structure; Flagella basal body p ring formation protein FlgA 570161 flgA 8195400 flgA Methylobacterium extorquens DM4 Flagella basal body p ring formation protein FlgA YP_003066305.1 569667 D 661410 CDS YP_003066306.1 254559211 8195389 570158..571285 1 NC_012988.1 part of the basal body which consists of four rings L, P, S, and M mounted on a central rod; Bradyrhizobium has one thick flagellum and several thin flagella; the Bradyrhizobium protein in this cluster is associated with the thin flagella; flagellar basal body P-ring protein 571285 flgI 8195389 flgI Methylobacterium extorquens DM4 flagellar basal body P-ring protein YP_003066306.1 570158 D 661410 CDS YP_003066307.1 254559212 8195404 571285..571869 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 571869 8195404 METDI0603 Methylobacterium extorquens DM4 hypothetical protein YP_003066307.1 571285 D 661410 CDS YP_003066308.1 254559213 8190986 571869..572576 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type s : structure; flagellar L-ring protein FlgH 572576 flgH 8190986 flgH Methylobacterium extorquens DM4 flagellar L-ring protein FlgH YP_003066308.1 571869 D 661410 CDS YP_003066309.1 254559214 8195402 572657..573139 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type s : structure; Flagellar basal body-associated protein FliL 573139 fliL 8195402 fliL Methylobacterium extorquens DM4 Flagellar basal body-associated protein FliL YP_003066309.1 572657 D 661410 CDS YP_003066310.1 254559215 8195421 573136..573918 1 NC_012988.1 FliP, with proteins FliQ and FliR, forms the core of the central channel in the flagella export apparatus; Bradyrhizobium have one thick flagellum and several thin flagella; the Bradyrhizobium protein in this cluster is associated with the thin flagellum; flagellar biosynthesis protein FliP 573918 fliP 8195421 fliP Methylobacterium extorquens DM4 flagellar biosynthesis protein FliP YP_003066310.1 573136 D 661410 CDS YP_003066311.1 254559216 8195427 574424..576103 1 NC_012988.1 the MS-ring anchors the flagellum to the cytoplasmic membrane; part of the flagellar basal body which consists of four rings L, P, S, and M mounted on a central rod; flagellar MS-ring protein 576103 fliF 8195427 fliF Methylobacterium extorquens DM4 flagellar MS-ring protein YP_003066311.1 574424 D 661410 CDS YP_003066312.1 254559217 8195415 576103..576828 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 576828 8195415 METDI0609 Methylobacterium extorquens DM4 hypothetical protein YP_003066312.1 576103 D 661410 CDS YP_003066313.1 254559218 8190987 576830..578254 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type s : structure; Chemotaxis protein MotB 578254 motB 8190987 motB Methylobacterium extorquens DM4 Chemotaxis protein MotB YP_003066313.1 576830 D 661410 CDS YP_003066314.1 254559219 8195717 578254..579633 1 NC_012988.1 a periplasmic protein that interacts with and stabilizes MotB; in Rhizobium, interactions between MotB and MotC at the periplasmic surface of the motor control the energy flux or the energy coupling that drives flagellar rotation; chemotaxis protein 579633 motC 8195717 motC Methylobacterium extorquens DM4 chemotaxis protein YP_003066314.1 578254 D 661410 CDS YP_003066315.1 254559220 8195719 579673..581526 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 581526 8195719 METDI0612 Methylobacterium extorquens DM4 hypothetical protein YP_003066315.1 579673 D 661410 CDS YP_003066316.1 254559221 8190988 581480..582148 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 582148 8190988 METDI0613 Methylobacterium extorquens DM4 hypothetical protein YP_003066316.1 581480 D 661410 CDS YP_003066317.1 254559222 8190989 complement(582156..582857) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type r : regulator; Two-component response regulator 582857 8190989 METDI0615 Methylobacterium extorquens DM4 Two-component response regulator YP_003066317.1 582156 R 661410 CDS YP_003066318.1 254559223 8190990 complement(583079..583525) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 583525 8190990 METDI0616 Methylobacterium extorquens DM4 hypothetical protein YP_003066318.1 583079 R 661410 CDS YP_003066319.1 254559224 8190991 complement(583522..584583) 1 NC_012988.1 membrane protein responsible for substrate specificity switching from rod/hook-type export to filament-type export; Bradyrhizobium has one thick flagellum and several thin flagella; the Bradyrhizobium protein in this cluster is associated with the thin flagella; flagellar biosynthesis protein FlhB 584583 flhB 8190991 flhB Methylobacterium extorquens DM4 flagellar biosynthesis protein FlhB YP_003066319.1 583522 R 661410 CDS YP_003066320.1 254559225 8195411 complement(584627..585706) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type s : structure; flagellar motor switch protein FliG 585706 fliG 8195411 fliG Methylobacterium extorquens DM4 flagellar motor switch protein FliG YP_003066320.1 584627 R 661410 CDS YP_003066321.1 254559226 8195417 complement(585729..586055) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type s : structure; flagellar motor switch protein fliN 586055 fliN 8195417 fliN Methylobacterium extorquens DM4 flagellar motor switch protein fliN YP_003066321.1 585729 R 661410 CDS YP_003066322.1 254559227 8195425 586256..586528 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 586528 8195425 METDI0620 Methylobacterium extorquens DM4 hypothetical protein YP_003066322.1 586256 D 661410 CDS YP_003066323.1 254559228 8190992 complement(586542..586838) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 586838 8190992 METDI0621 Methylobacterium extorquens DM4 hypothetical protein YP_003066323.1 586542 R 661410 CDS YP_003066324.1 254559229 8190993 complement(586822..587844) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type s : structure; Flagellar motor switch protein FliM 587844 fliM 8190993 fliM Methylobacterium extorquens DM4 Flagellar motor switch protein FliM YP_003066324.1 586822 R 661410 CDS YP_003066325.1 254559230 8195423 complement(587859..588734) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type s : structure; Chemotaxis protein MotA (Motility protein A) 588734 motA 8195423 motA Methylobacterium extorquens DM4 Chemotaxis protein MotA (Motility protein A) YP_003066325.1 587859 R 661410 CDS YP_003066326.1 254559231 8195716 588933..589493 1 NC_012988.1 heat shock protein involved in degradation of misfolded proteins; ATP-dependent protease peptidase subunit 589493 hslV 8195716 hslV Methylobacterium extorquens DM4 ATP-dependent protease peptidase subunit YP_003066326.1 588933 D 661410 CDS YP_003066327.1 254559232 8195579 589605..590918 1 NC_012988.1 heat shock protein involved in degradation of misfolded proteins; ATP-dependent protease ATP-binding subunit HslU 590918 hslU 8195579 hslU Methylobacterium extorquens DM4 ATP-dependent protease ATP-binding subunit HslU YP_003066327.1 589605 D 661410 CDS YP_003066328.1 254559233 8195578 590921..591811 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8021175, 8930920; Product type pt : putative transporter; putative membrane protein DUF6 precursor, putative threonine and homoserine efflux protein 591811 8195578 METDI0626 Methylobacterium extorquens DM4 putative membrane protein DUF6 precursor, putative threonine and homoserine efflux protein YP_003066328.1 590921 D 661410 CDS YP_003066329.1 254559234 8190994 complement(591845..592906) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; Beta-lactamase-like 592906 8190994 METDI0627 Methylobacterium extorquens DM4 Beta-lactamase-like YP_003066329.1 591845 R 661410 CDS YP_003066330.1 254559235 8190995 complement(592956..594041) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative rieske 2Fe-2S family protein 594041 8190995 METDI0628 Methylobacterium extorquens DM4 putative rieske 2Fe-2S family protein YP_003066330.1 592956 R 661410 CDS YP_003066331.1 254559236 8190996 complement(594406..594912) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 594912 8190996 METDI0629 Methylobacterium extorquens DM4 hypothetical protein YP_003066331.1 594406 R 661410 CDS YP_003066332.1 254559237 8190997 595451..597013 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 6357787; Product type f : factor; signal recognition particle protein, GTPase 597013 ffh 8190997 ffh Methylobacterium extorquens DM4 signal recognition particle protein, GTPase YP_003066332.1 595451 D 661410 CDS YP_003066333.1 254559238 8195372 597010..597357 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12581215; Product type pe : putative enzyme; putative chorismate mutase 597357 8195372 METDI0633 Methylobacterium extorquens DM4 putative chorismate mutase YP_003066333.1 597010 D 661410 CDS YP_003066334.1 254559239 8190998 597357..597719 1 NC_012988.1 binds to lower part of 30S body where it stabilizes two domains; required for efficient assembly of 30S; in Escherichia coli this protein has nuclease activity; 30S ribosomal protein S16 597719 rpsP 8190998 rpsP Methylobacterium extorquens DM4 30S ribosomal protein S16 YP_003066334.1 597357 D 661410 CDS YP_003066335.1 254559240 8196067 597844..598515 1 NC_012988.1 Essential for efficient processing of 16S rRNA; 16S rRNA-processing protein RimM 598515 rimM 8196067 rimM Methylobacterium extorquens DM4 16S rRNA-processing protein RimM YP_003066335.1 597844 D 661410 CDS YP_003066336.1 254559241 8190999 complement(598523..599317) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 599317 8190999 METDI0636 Methylobacterium extorquens DM4 hypothetical protein YP_003066336.1 598523 R 661410 CDS YP_003066337.1 254559242 8191000 complement(599386..600117) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 600117 8191000 METDI0637 Methylobacterium extorquens DM4 hypothetical protein YP_003066337.1 599386 R 661410 CDS YP_003066338.1 254559243 8191001 600227..600544 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 600544 8191001 METDI0638 Methylobacterium extorquens DM4 hypothetical protein YP_003066338.1 600227 D 661410 CDS YP_003066339.1 254559244 8191002 600654..601376 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; tRNA (guanine)-methyltransferase 601376 trmD 8191002 trmD Methylobacterium extorquens DM4 tRNA (guanine)-methyltransferase YP_003066339.1 600654 D 661410 CDS YP_003066340.1 254559245 8196211 601550..602725 1 NC_012988.1 catalyzes the formation of 3-phosphonooxypyruvate and glutamate from O-phospho-L-serine and 2-oxoglutarate; phosphoserine aminotransferase 602725 serC1 8196211 serC1 Methylobacterium extorquens DM4 phosphoserine aminotransferase YP_003066340.1 601550 D 661410 CDS YP_003066341.1 254559246 8196111 602883..604490 1 NC_012988.1 catalyzes the formation of 3-phosphonooxypyruvate from 3-phospho-D-glycerate in serine biosynthesis; can also reduce alpha ketoglutarate to form 2-hydroxyglutarate; D-3-phosphoglycerate dehydrogenase 604490 serA2 8196111 serA2 Methylobacterium extorquens DM4 D-3-phosphoglycerate dehydrogenase YP_003066341.1 602883 D 661410 CDS YP_003066342.1 254559247 8196110 604468..604818 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 604818 8196110 METDI0642 Methylobacterium extorquens DM4 hypothetical protein YP_003066342.1 604468 D 661410 CDS YP_003066343.1 254559248 8191003 604961..606058 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor; putative translation initiation factor, aIF-2B alpha subunit (eIF-2B) 606058 8191003 METDI0643 Methylobacterium extorquens DM4 putative translation initiation factor, aIF-2B alpha subunit (eIF-2B) YP_003066343.1 604961 D 661410 CDS YP_003066344.1 254559249 8191004 complement(606070..606417) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type e : enzyme; putative DNA-binding protein 606417 8191004 METDI0644 Methylobacterium extorquens DM4 putative DNA-binding protein YP_003066344.1 606070 R 661410 CDS YP_003066345.1 254559250 8191005 complement(606483..607901) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative multidrug efflux system transporter mdtK 607901 8191005 METDI0645 Methylobacterium extorquens DM4 putative multidrug efflux system transporter mdtK YP_003066345.1 606483 R 661410 CDS YP_003066346.1 254559251 8191006 complement(607926..609782) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type t : transporter; ABC transporter, fused ATPase and permease domains 609782 8191006 METDI0646 Methylobacterium extorquens DM4 ABC transporter, fused ATPase and permease domains YP_003066346.1 607926 R 661410 CDS YP_003066347.1 254559252 8191007 609923..610372 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative rRNA methylase 610372 8191007 METDI0647 Methylobacterium extorquens DM4 putative rRNA methylase YP_003066347.1 609923 D 661410 CDS YP_003066348.1 254559253 8191008 610666..612300 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type cp : cell process; putative methyl-accepting chemotaxis sensory transducer 612300 8191008 METDI0648 Methylobacterium extorquens DM4 putative methyl-accepting chemotaxis sensory transducer YP_003066348.1 610666 D 661410 CDS YP_003066349.1 254559254 8191009 612563..613702 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 613702 8191009 METDI0649 Methylobacterium extorquens DM4 hypothetical protein YP_003066349.1 612563 D 661410 CDS YP_003066350.1 254559255 8191010 613699..614367 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 614367 8191010 METDI0650 Methylobacterium extorquens DM4 hypothetical protein YP_003066350.1 613699 D 661410 CDS YP_003066351.1 254559256 8191011 614404..616110 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; putative inner membrane protein (yqiK-like) 616110 8191011 METDI0651 Methylobacterium extorquens DM4 putative inner membrane protein (yqiK-like) YP_003066351.1 614404 D 661410 CDS YP_003066352.1 254559257 8191012 616302..618488 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type prc : putative receptor; putative TonB-dependent siderophore receptor 618488 8191012 METDI0652 Methylobacterium extorquens DM4 putative TonB-dependent siderophore receptor YP_003066352.1 616302 D 661410 CDS YP_003066353.1 254559258 8191013 618532..619455 1 NC_012988.1 catalyzes the conversion of the propionic acid groups of rings I and III to vinyl groups during heme synthesis; coproporphyrinogen III oxidase 619455 hemF 8191013 hemF Methylobacterium extorquens DM4 coproporphyrinogen III oxidase YP_003066353.1 618532 D 661410 CDS YP_003066354.1 254559259 8195552 619503..620624 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; Exodeoxyribonuclease V 620624 8195552 METDI0654 Methylobacterium extorquens DM4 Exodeoxyribonuclease V YP_003066354.1 619503 D 661410 CDS YP_003066355.1 254559260 8191014 complement(620788..622065) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 622065 8191014 METDI0655 Methylobacterium extorquens DM4 hypothetical protein YP_003066355.1 620788 R 661410 CDS YP_003066356.1 254559261 8191015 622450..623130 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type r : regulator; Two-component response regulator 623130 8191015 METDI0656 Methylobacterium extorquens DM4 Two-component response regulator YP_003066356.1 622450 D 661410 CDS YP_003066357.1 254559262 8191016 complement(623238..624635) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11514517, 2921241; Product type s : structure; putative flagellin (flaA-like; flaB-like) 624635 8191016 METDI0657 Methylobacterium extorquens DM4 putative flagellin (flaA-like; flaB-like) YP_003066357.1 623238 R 661410 CDS YP_003066358.1 254559263 8191017 complement(625158..625457) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 625457 8191017 METDI0659 Methylobacterium extorquens DM4 hypothetical protein YP_003066358.1 625158 R 661410 CDS YP_003066359.1 254559264 8191018 625660..626229 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 626229 8191018 METDI0660 Methylobacterium extorquens DM4 hypothetical protein YP_003066359.1 625660 D 661410 CDS YP_003066360.1 254559265 8191019 626402..627655 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 627655 8191019 METDI0661 Methylobacterium extorquens DM4 hypothetical protein YP_003066360.1 626402 D 661410 CDS YP_003066361.1 254559266 8191020 627661..628389 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type s : structure; Flagellar basal-body rod protein flgF 628389 flgF 8191020 flgF Methylobacterium extorquens DM4 Flagellar basal-body rod protein flgF YP_003066361.1 627661 D 661410 CDS YP_003066362.1 254559267 8195398 628394..629722 1 NC_012988.1 involved in type III protein export during flagellum assembly; flagellum-specific ATP synthase 629722 fliI 8195398 fliI Methylobacterium extorquens DM4 flagellum-specific ATP synthase YP_003066362.1 628394 D 661410 CDS YP_003066363.1 254559268 8195419 629805..631016 1 NC_012988.1 the hook connects flagellar basal body to the flagellar filament; flagellar hook protein FlgE 631016 flgE 8195419 flgE Methylobacterium extorquens DM4 flagellar hook protein FlgE YP_003066363.1 629805 D 661410 CDS YP_003066364.1 254559269 8195396 631095..632558 1 NC_012988.1 with FlgL acts as a hook filament junction protein to join the flagellar filament to the hook; flagellar hook-associated protein FlgK 632558 flgK 8195396 flgK Methylobacterium extorquens DM4 flagellar hook-associated protein FlgK YP_003066364.1 631095 D 661410 CDS YP_003066365.1 254559270 8195406 632566..633618 1 NC_012988.1 with FlgK acts as a hook filament junction protein to join the flagellar filament to the hook; Bradyrhizobium has one thick flagellum and several thin flagella; the Bradyrhizobium protein in this cluster is associated with the thin flagella; flagellar hook-associated protein FlgL 633618 flgL 8195406 flgL Methylobacterium extorquens DM4 flagellar hook-associated protein FlgL YP_003066365.1 632566 D 661410 CDS YP_003066366.1 254559271 8195408 633659..634009 1 NC_012988.1 acts as an activator or flagellin translation and may be required for filament secretion or assembly; Bradyrhizobium has one thick flagellum and several thin flagella; the protein in this cluster is associated with the thin flagella; flagellar biosynthesis regulatory protein FlaF 634009 flaF 8195408 flaF Methylobacterium extorquens DM4 flagellar biosynthesis regulatory protein FlaF YP_003066366.1 633659 D 661410 CDS YP_003066367.1 254559272 8195386 634020..634541 1 NC_012988.1 post-transcriptional repressor of flagellum biosynthesis; promotes degradation of fljK mRNA: Bradyrhizobium has one thick flagellum and several thin flagella; the protein in this cluster is associated with the thin flagella; flagellar biosynthesis repressor FlbT 634541 flbT 8195386 flbT Methylobacterium extorquens DM4 flagellar biosynthesis repressor FlbT YP_003066367.1 634020 D 661410 CDS YP_003066368.1 254559273 8195388 634548..634964 1 NC_012988.1 acts as a scaffold for the assembly of hook proteins onto the flagellar basal body rod; Yersinia, Vibrio parahaemolyticus, Bradyrhizobium and other organisms have 2 copies of some flagellar genes; Bradyrhizobium has one thick flagellum and several thin flagella; the protein in this cluster is associated with the thin flagella; flagellar basal body rod modification protein 634964 flgD 8195388 flgD Methylobacterium extorquens DM4 flagellar basal body rod modification protein YP_003066368.1 634548 D 661410 CDS YP_003066369.1 254559274 8195395 635031..635297 1 NC_012988.1 FliQ, with proteins FliP and FliR, forms the core of the central channel in the flagella export apparatus; Bradyrhizobium have one thick flagellum and several thin flagella; the protein in this cluster is associated with the thick flagellum; flagellar biosynthesis protein FliQ 635297 fliQ 8195395 fliQ Methylobacterium extorquens DM4 flagellar biosynthesis protein FliQ YP_003066369.1 635031 D 661410 CDS YP_003066370.1 254559275 8191021 635640..637721 1 NC_012988.1 membrane protein involved in the flagellar export apparatus; flagellar biosynthesis protein FlhA 637721 flhA 8191021 flhA Methylobacterium extorquens DM4 flagellar biosynthesis protein FlhA YP_003066370.1 635640 D 661410 CDS YP_003066371.1 254559276 8195409 637718..638488 1 NC_012988.1 FliR, with proteins FliP and FliQ, forms the core of the central channel in the flagella export apparatus; Bradyrhizobium has one thick and several thin flagella; the Bradyrhizobium protein in this cluster are associated with the thin flagella; flagellar biosynthesis protein FliR 638488 fliR 8195409 fliR Methylobacterium extorquens DM4 flagellar biosynthesis protein FliR YP_003066371.1 637718 D 661410 CDS YP_003066372.1 254559277 8195429 638494..638904 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 638904 8195429 METDI0673 Methylobacterium extorquens DM4 hypothetical protein YP_003066372.1 638494 D 661410 CDS YP_003066373.1 254559278 8191022 638980..639450 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 639450 8191022 METDI0674 Methylobacterium extorquens DM4 hypothetical protein YP_003066373.1 638980 D 661410 CDS YP_003066374.1 254559279 8191023 639456..639800 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 639800 8191023 METDI0675 Methylobacterium extorquens DM4 hypothetical protein YP_003066374.1 639456 D 661410 CDS YP_003066375.1 254559280 8191024 639804..640250 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 640250 8191024 METDI0676 Methylobacterium extorquens DM4 hypothetical protein YP_003066375.1 639804 D 661410 CDS YP_003066376.1 254559281 8191025 640346..641239 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative dihydrodipicolinate synthase (dapA-like) 641239 8191025 METDI0677 Methylobacterium extorquens DM4 putative dihydrodipicolinate synthase (dapA-like) YP_003066376.1 640346 D 661410 CDS YP_003066377.1 254559282 8191026 641341..642327 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 642327 8191026 METDI0678 Methylobacterium extorquens DM4 hypothetical protein YP_003066377.1 641341 D 661410 CDS YP_003066378.1 254559283 8191027 complement(642343..642684) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 642684 8191027 METDI0679 Methylobacterium extorquens DM4 hypothetical protein YP_003066378.1 642343 R 661410 CDS YP_003066379.1 254559284 8191028 complement(642746..643495) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 643495 8191028 METDI0680 Methylobacterium extorquens DM4 hypothetical protein YP_003066379.1 642746 R 661410 CDS YP_003066380.1 254559285 8191029 complement(643539..645479) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 1438215; Product type e : enzyme; Two-component sensor histidine kinase with a PAS domain 645479 8191029 METDI0681 Methylobacterium extorquens DM4 Two-component sensor histidine kinase with a PAS domain YP_003066380.1 643539 R 661410 CDS YP_003066381.1 254559286 8191030 645858..646190 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 646190 8191030 METDI0682 Methylobacterium extorquens DM4 hypothetical protein YP_003066381.1 645858 D 661410 CDS YP_003066382.1 254559287 8191031 646342..647385 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 11064196; Product type e : enzyme; Cytochrome bd ubiquinol oxidase, subunit II 647385 qxtB 8191031 qxtB Methylobacterium extorquens DM4 Cytochrome bd ubiquinol oxidase, subunit II YP_003066382.1 646342 D 661410 CDS YP_003066383.1 254559288 8195957 complement(647616..648845) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type t : transporter; Major facilitator superfamily transport protein 648845 8195957 METDI0686 Methylobacterium extorquens DM4 Major facilitator superfamily transport protein YP_003066383.1 647616 R 661410 CDS YP_003066384.1 254559289 8191032 complement(648926..650143) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type t : transporter; Major facilitator superfamily transport protein 650143 8191032 METDI0687 Methylobacterium extorquens DM4 Major facilitator superfamily transport protein YP_003066384.1 648926 R 661410 CDS YP_003066385.1 254559290 8191033 650250..650702 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcriptional regulator, HxlR family 650702 8191033 METDI0688 Methylobacterium extorquens DM4 putative transcriptional regulator, HxlR family YP_003066385.1 650250 D 661410 CDS YP_003066386.1 254559291 8191034 650999..653491 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 8335642; Product type e : enzyme; Penicillin-binding protein 1A 653491 8191034 METDI0689 Methylobacterium extorquens DM4 Penicillin-binding protein 1A YP_003066386.1 650999 D 661410 CDS YP_003066387.1 254559292 8191035 653698..655395 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 9163424; Product type pr : putative regulator; putative Methyl-accepting chemotaxis protein/ histidine kinase 655395 8191035 METDI0690 Methylobacterium extorquens DM4 putative Methyl-accepting chemotaxis protein/ histidine kinase YP_003066387.1 653698 D 661410 CDS YP_003066388.1 254559293 8191036 complement(655511..656998) 1 NC_012988.1 Catalyzes the hydrolysis of AMP to form adenine and ribose 5-phosphate using water as the nucleophile; AMP nucleosidase 656998 amn 8191036 amn Methylobacterium extorquens DM4 AMP nucleosidase YP_003066388.1 655511 R 661410 CDS YP_003066389.1 254559294 8195072 657180..657686 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 657686 8195072 METDI0692 Methylobacterium extorquens DM4 hypothetical protein YP_003066389.1 657180 D 661410 CDS YP_003066390.1 254559295 8191037 complement(657706..659016) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 659016 8191037 METDI0693 Methylobacterium extorquens DM4 hypothetical protein YP_003066390.1 657706 R 661410 CDS YP_003066391.1 254559296 8191038 complement(659225..660067) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 660067 8191038 METDI0694 Methylobacterium extorquens DM4 hypothetical protein YP_003066391.1 659225 R 661410 CDS YP_003066392.1 254559297 8191039 complement(660539..660970) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 660970 8191039 METDI0695 Methylobacterium extorquens DM4 hypothetical protein YP_003066392.1 660539 R 661410 CDS YP_003066393.1 254559298 8191040 complement(661032..661925) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 11259647; Product type e : enzyme; Histone deacetylase family protein 661925 8191040 METDI0696 Methylobacterium extorquens DM4 Histone deacetylase family protein YP_003066393.1 661032 R 661410 CDS YP_003066394.1 254559299 8191041 662041..663225 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; Ceramide glucosyltransferase 663225 8191041 METDI0697 Methylobacterium extorquens DM4 Ceramide glucosyltransferase YP_003066394.1 662041 D 661410 CDS YP_003066395.1 254559300 8191042 663727..665274 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 14675535; Product type ps : putative structure; putative crescentin ( creS ) 665274 8191042 METDI0698 Methylobacterium extorquens DM4 putative crescentin ( creS ) YP_003066395.1 663727 D 661410 CDS YP_003066396.1 254559301 8191043 665331..665822 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 665822 8191043 METDI0699 Methylobacterium extorquens DM4 hypothetical protein YP_003066396.1 665331 D 661410 CDS YP_003066397.1 254559302 8191044 665840..666346 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 666346 8191044 METDI0700 Methylobacterium extorquens DM4 hypothetical protein YP_003066397.1 665840 D 661410 CDS YP_003066398.1 254559303 8191045 666568..667944 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type t : transporter; permease; putative ethanolamine transporter 667944 8191045 METDI0701 Methylobacterium extorquens DM4 permease; putative ethanolamine transporter YP_003066398.1 666568 D 661410 CDS YP_003066399.1 254559304 8191046 complement(668149..669081) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative fatty acid desaturase ; putative membrane component 669081 8191046 METDI0702 Methylobacterium extorquens DM4 putative fatty acid desaturase ; putative membrane component YP_003066399.1 668149 R 661410 CDS YP_003066400.1 254559305 8191047 669115..669486 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcriptional regulator, ArsR family 669486 8191047 METDI0703 Methylobacterium extorquens DM4 putative transcriptional regulator, ArsR family YP_003066400.1 669115 D 661410 CDS YP_003066401.1 254559306 8191048 670101..670793 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative Glutamine amidotransferase, class-I family protein (guaA-like) 670793 8191048 METDI0704 Methylobacterium extorquens DM4 putative Glutamine amidotransferase, class-I family protein (guaA-like) YP_003066401.1 670101 D 661410 CDS YP_003066402.1 254559307 8191049 complement(670898..671914) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative oxidoreductase, aldo/keto reductase family 671914 8191049 METDI0705 Methylobacterium extorquens DM4 putative oxidoreductase, aldo/keto reductase family YP_003066402.1 670898 R 661410 CDS YP_003066403.1 254559308 8191050 672063..672974 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type r : regulator; Transcriptional regulator, AraC family 672974 8191050 METDI0706 Methylobacterium extorquens DM4 Transcriptional regulator, AraC family YP_003066403.1 672063 D 661410 CDS YP_003066404.1 254559309 8191051 673123..674445 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative integrase 674445 8191051 METDI0707 Methylobacterium extorquens DM4 putative integrase YP_003066404.1 673123 D 661410 CDS YP_003066405.1 254559310 8191055 676038..676352 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 676352 8191055 METDI0712 Methylobacterium extorquens DM4 hypothetical protein YP_003066405.1 676038 D 661410 CDS YP_003066406.1 254559311 8191056 676784..677932 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 677932 8191056 METDI0713 Methylobacterium extorquens DM4 hypothetical protein YP_003066406.1 676784 D 661410 CDS YP_003066407.1 254559312 8191057 677929..678159 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 678159 8191057 METDI0714 Methylobacterium extorquens DM4 hypothetical protein YP_003066407.1 677929 D 661410 CDS YP_003066408.1 254559313 8191059 complement(678468..679220) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; transposase of ISMdi3, IS3 family (ORF 2) 679220 8191059 METDI0716 Methylobacterium extorquens DM4 transposase of ISMdi3, IS3 family (ORF 2) YP_003066408.1 678468 R 661410 CDS YP_003066409.1 254559314 8191060 complement(679328..679609) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; transposase of ISMdi3, IS3 family (ORF 1) 679609 8191060 METDI0717 Methylobacterium extorquens DM4 transposase of ISMdi3, IS3 family (ORF 1) YP_003066409.1 679328 R 661410 CDS YP_003066410.1 254559315 8191063 complement(680494..680952) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 680952 8191063 METDI0720 Methylobacterium extorquens DM4 hypothetical protein YP_003066410.1 680494 R 661410 CDS YP_003066411.1 254559316 8191064 681019..681360 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcriptional regulator, ArsR family 681360 8191064 METDI0722 Methylobacterium extorquens DM4 putative transcriptional regulator, ArsR family YP_003066411.1 681019 D 661410 CDS YP_003066412.1 254559317 8191065 681368..681793 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 681793 8191065 METDI0723 Methylobacterium extorquens DM4 hypothetical protein YP_003066412.1 681368 D 661410 CDS YP_003066413.1 254559318 8191066 681799..682257 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 682257 8191066 METDI0724 Methylobacterium extorquens DM4 hypothetical protein YP_003066413.1 681799 D 661410 CDS YP_003066414.1 254559319 8191067 682254..683063 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 683063 8191067 METDI0725 Methylobacterium extorquens DM4 hypothetical protein YP_003066414.1 682254 D 661410 CDS YP_003066415.1 254559320 8191068 683085..683996 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; beta-lactamase domain protein, putative hydroxyacylglutathione hydrolase 683996 8191068 METDI0726 Methylobacterium extorquens DM4 beta-lactamase domain protein, putative hydroxyacylglutathione hydrolase YP_003066415.1 683085 D 661410 CDS YP_003066416.1 254559321 8191069 683993..684394 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; rhodanese domain protein, putative sulfur transferase 684394 8191069 METDI0727 Methylobacterium extorquens DM4 rhodanese domain protein, putative sulfur transferase YP_003066416.1 683993 D 661410 CDS YP_003066417.1 254559322 8191070 complement(684751..686067) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type rc : receptor; integral membrane sensor signal transduction histidine kinase precursor 686067 8191070 METDI0728 Methylobacterium extorquens DM4 integral membrane sensor signal transduction histidine kinase precursor YP_003066417.1 684751 R 661410 CDS YP_003066418.1 254559323 8191071 complement(686064..686726) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 21927389; Product type r : regulator; DNA-binding response regulator in two-component regulatory system 686726 8191071 METDI0729 Methylobacterium extorquens DM4 DNA-binding response regulator in two-component regulatory system YP_003066418.1 686064 R 661410 CDS YP_003066419.1 254559324 8191072 686833..688605 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative fused thiol:disulfide interchange protein precursor 688605 8191072 METDI0730 Methylobacterium extorquens DM4 putative fused thiol:disulfide interchange protein precursor YP_003066419.1 686833 D 661410 CDS YP_003066420.1 254559325 8191073 688645..689280 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative thioredoxin domain protein precursor 689280 8191073 METDI0731 Methylobacterium extorquens DM4 putative thioredoxin domain protein precursor YP_003066420.1 688645 D 661410 CDS YP_003066421.1 254559326 8191074 689280..690128 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 690128 8191074 METDI0732 Methylobacterium extorquens DM4 hypothetical protein YP_003066421.1 689280 D 661410 CDS YP_003066422.1 254559327 8191075 691319..694636 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type t : transporter; putative cation efflux system protein 694636 ragC 8191075 ragC Methylobacterium extorquens DM4 putative cation efflux system protein YP_003066422.1 691319 D 661410 CDS YP_003066423.1 254559328 8195961 694623..695903 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 10675036; Product type t : transporter; Efflux transporter, RND family, membrane fusion protein subunit; RagD-related 695903 8195961 METDI0737 Methylobacterium extorquens DM4 Efflux transporter, RND family, membrane fusion protein subunit; RagD-related YP_003066423.1 694623 D 661410 CDS YP_003066424.1 254559329 8191076 complement(696009..696311) 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 696311 8191076 METDI0738 Methylobacterium extorquens DM4 hypothetical protein YP_003066424.1 696009 R 661410 CDS YP_003066425.1 254559330 8191077 696636..697358 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 697358 8191077 METDI0739 Methylobacterium extorquens DM4 hypothetical protein YP_003066425.1 696636 D 661410 CDS YP_003066426.1 254559331 8191078 697572..697937 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 697937 8191078 METDI0740 Methylobacterium extorquens DM4 hypothetical protein YP_003066426.1 697572 D 661410 CDS YP_003066427.1 254559332 8191079 697957..698760 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier; putative thiol:disulfide interchange protein 698760 8191079 METDI0741 Methylobacterium extorquens DM4 putative thiol:disulfide interchange protein YP_003066427.1 697957 D 661410 CDS YP_003066428.1 254559333 8191080 698800..699315 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative nuclease precursor 699315 8191080 METDI0742 Methylobacterium extorquens DM4 putative nuclease precursor YP_003066428.1 698800 D 661410 CDS YP_003066429.1 254559334 8191082 699571..699762 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 699762 8191082 METDI0744 Methylobacterium extorquens DM4 hypothetical protein YP_003066429.1 699571 D 661410 CDS YP_003066430.1 254559335 8191083 699832..700047 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 700047 8191083 METDI0745 Methylobacterium extorquens DM4 hypothetical protein YP_003066430.1 699832 D 661410 CDS YP_003066431.1 254559336 8191085 complement(700827..701498) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative transglutaminase-like cysteine peptidase precursor 701498 8191085 METDI0747 Methylobacterium extorquens DM4 putative transglutaminase-like cysteine peptidase precursor YP_003066431.1 700827 R 661410 CDS YP_003066432.1 254559337 8191086 complement(701711..702730) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 16517654; Product type e : enzyme; transposase of ISMdi4, IS481 family 702730 8191086 METDI0748 Methylobacterium extorquens DM4 transposase of ISMdi4, IS481 family YP_003066432.1 701711 R 661410 CDS YP_003066433.1 254559338 8191087 complement(702857..703846) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15665824; Product type e : enzyme; putative sulfate-binding protein 703846 8191087 METDI0749 Methylobacterium extorquens DM4 putative sulfate-binding protein YP_003066433.1 702857 R 661410 CDS YP_003066434.1 254559339 8191088 complement(703856..704323) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 704323 8191088 METDI0750 Methylobacterium extorquens DM4 hypothetical protein YP_003066434.1 703856 R 661410 CDS YP_003066435.1 254559340 8191089 complement(704393..704854) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 704854 8191089 METDI0751 Methylobacterium extorquens DM4 hypothetical protein YP_003066435.1 704393 R 661410 CDS YP_003066436.1 254559341 8191090 complement(704950..705915) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative metallo-beta-lactamase family protein 705915 8191090 METDI0752 Methylobacterium extorquens DM4 putative metallo-beta-lactamase family protein YP_003066436.1 704950 R 661410 CDS YP_003066437.1 254559342 8191091 complement(705942..706622) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier; putative sulfite oxidase cytochrome subunit (SoxD) 706622 8191091 METDI0753 Methylobacterium extorquens DM4 putative sulfite oxidase cytochrome subunit (SoxD) YP_003066437.1 705942 R 661410 CDS YP_003066438.1 254559343 8191092 complement(706606..707895) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; sulfite oxidase precursor (tat pathway signal) 707895 soxC 8191092 soxC Methylobacterium extorquens DM4 sulfite oxidase precursor (tat pathway signal) YP_003066438.1 706606 R 661410 CDS YP_003066439.1 254559344 8196129 complement(707949..709628) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; sulfur/thiosulfate oxidation protein precursor (tat pathway signal) 709628 soxB 8196129 soxB Methylobacterium extorquens DM4 sulfur/thiosulfate oxidation protein precursor (tat pathway signal) YP_003066439.1 707949 R 661410 CDS YP_003066440.1 254559345 8196126 complement(709644..710486) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 11567011, 12411478; Product type c : carrier; diheme cytochrome c, sulfur oxidising protein SoxA 710486 soxA 8196126 soxA Methylobacterium extorquens DM4 diheme cytochrome c, sulfur oxidising protein SoxA YP_003066440.1 709644 R 661410 CDS YP_003066441.1 254559346 8196123 complement(710674..711003) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 11285738, 14645228; Product type e : enzyme; sulfur oxidation protein SoxZ 711003 soxZ 8196123 soxZ Methylobacterium extorquens DM4 sulfur oxidation protein SoxZ YP_003066441.1 710674 R 661410 CDS YP_003066442.1 254559347 8196141 complement(711045..711524) 1 NC_012988.1 with SoxZ catalyzes the oxidation of sulfur compounds; sulfur oxidation protein SoxY 711524 soxY 8196141 soxY Methylobacterium extorquens DM4 sulfur oxidation protein SoxY YP_003066442.1 711045 R 661410 CDS YP_003066443.1 254559348 8196140 complement(711521..711997) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 11567011, 12411478, 12597275; Product type c : carrier; cytochrome c SoxX precursor 711997 soxX 8196140 soxX Methylobacterium extorquens DM4 cytochrome c SoxX precursor YP_003066443.1 711521 R 661410 CDS YP_003066444.1 254559349 8196139 complement(712166..712741) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; Thioredoxin SoxW protein 712741 soxW 8196139 soxW Methylobacterium extorquens DM4 Thioredoxin SoxW protein YP_003066444.1 712166 R 661410 CDS YP_003066445.1 254559350 8196138 712772..713560 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 713560 8196138 METDI0761 Methylobacterium extorquens DM4 hypothetical protein YP_003066445.1 712772 D 661410 CDS YP_003066446.1 254559351 8191093 complement(713604..714338) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; sulfur oxidation V protein, cytochrome c-type biogenesis protein 714338 soxV 8191093 soxV Methylobacterium extorquens DM4 sulfur oxidation V protein, cytochrome c-type biogenesis protein YP_003066446.1 713604 R 661410 CDS YP_003066447.1 254559352 8196137 714435..714779 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 10894738, 11567011; Product type e : enzyme; regulatory protein SoxS precursor 714779 soxS 8196137 soxS Methylobacterium extorquens DM4 regulatory protein SoxS precursor YP_003066447.1 714435 D 661410 CDS YP_003066448.1 254559353 8196135 714835..715191 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type pr : putative regulator; transcriptional regulator, ArsR family; putative SoxR protein 715191 soxR 8196135 soxR Methylobacterium extorquens DM4 transcriptional regulator, ArsR family; putative SoxR protein YP_003066448.1 714835 D 661410 CDS YP_003066449.1 254559354 8196134 complement(715285..715785) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 715785 8196134 METDI0765 Methylobacterium extorquens DM4 hypothetical protein YP_003066449.1 715285 R 661410 CDS YP_003066450.1 254559355 8191094 complement(715933..716985) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type t : transporter; SoxT protein, YeeE/YedE family protein 716985 soxT 8191094 soxT Methylobacterium extorquens DM4 SoxT protein, YeeE/YedE family protein YP_003066450.1 715933 R 661410 CDS YP_003066451.1 254559356 8196136 complement(717385..717948) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative MFS transporter superfamily protein domain 717948 8196136 METDI0769 Methylobacterium extorquens DM4 putative MFS transporter superfamily protein domain YP_003066451.1 717385 R 661410 CDS YP_003066452.1 254559357 8191095 complement(718644..719042) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 719042 8191095 METDI0771 Methylobacterium extorquens DM4 hypothetical protein YP_003066452.1 718644 R 661410 CDS YP_003066453.1 254559358 8191096 719598..720038 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 720038 8191096 METDI0772 Methylobacterium extorquens DM4 hypothetical protein YP_003066453.1 719598 D 661410 CDS YP_003066454.1 254559359 8191098 720498..720725 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 720725 8191098 METDI0774 Methylobacterium extorquens DM4 hypothetical protein YP_003066454.1 720498 D 661410 CDS YP_003066455.1 254559360 8191099 complement(720822..721727) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; succinyl-CoA synthetase, alpha subunit 721727 sucD 8191099 sucD Methylobacterium extorquens DM4 succinyl-CoA synthetase, alpha subunit YP_003066455.1 720822 R 661410 CDS YP_003066456.1 254559361 8196168 complement(721724..722890) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; succinyl-CoA synthetase, beta subunit 722890 sucC 8196168 sucC Methylobacterium extorquens DM4 succinyl-CoA synthetase, beta subunit YP_003066456.1 721724 R 661410 CDS YP_003066457.1 254559362 8196166 complement(722887..724278) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8550525; Product type pe : putative enzyme; putative succinate-semialdehyde dehydrogenase 724278 8196166 METDI0777 Methylobacterium extorquens DM4 putative succinate-semialdehyde dehydrogenase YP_003066457.1 722887 R 661410 CDS YP_003066458.1 254559363 8191100 complement(724454..725725) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative transporter, major facilitator superfamily 725725 8191100 METDI0778 Methylobacterium extorquens DM4 putative transporter, major facilitator superfamily YP_003066458.1 724454 R 661410 CDS YP_003066459.1 254559364 8191101 726043..726861 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type r : regulator; transcriptional regulator, LysR family 726861 8191101 METDI0779 Methylobacterium extorquens DM4 transcriptional regulator, LysR family YP_003066459.1 726043 D 661410 CDS YP_003066460.1 254559365 8191102 726987..727199 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 727199 8191102 METDI0780 Methylobacterium extorquens DM4 hypothetical protein YP_003066460.1 726987 D 661410 CDS YP_003066461.1 254559366 8191103 727483..729183 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; glucose-methanol-choline oxidoreductase 729183 8191103 METDI0781 Methylobacterium extorquens DM4 glucose-methanol-choline oxidoreductase YP_003066461.1 727483 D 661410 CDS YP_003066462.1 254559367 8191104 729180..730568 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type t : transporter; MFS transporter membrane protein 730568 8191104 METDI0782 Methylobacterium extorquens DM4 MFS transporter membrane protein YP_003066462.1 729180 D 661410 CDS YP_003066463.1 254559368 8191105 730708..731733 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 731733 8191105 METDI0783 Methylobacterium extorquens DM4 hypothetical protein YP_003066463.1 730708 D 661410 CDS YP_003066464.1 254559369 8191106 731790..732995 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 10788424, 11285738; Product type e : enzyme; Sulfite:cytochrome c oxidoreductase subunit A 732995 sorA 8191106 sorA Methylobacterium extorquens DM4 Sulfite:cytochrome c oxidoreductase subunit A YP_003066464.1 731790 D 661410 CDS YP_003066465.1 254559370 8196122 733007..733345 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 10788424; Product type e : enzyme; Sulfite:cytochrome c oxidoreductase subunit B precursor 733345 8196122 METDI0785 Methylobacterium extorquens DM4 Sulfite:cytochrome c oxidoreductase subunit B precursor YP_003066465.1 733007 D 661410 CDS YP_003066466.1 254559371 8191107 733379..734722 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative sulfite oxidase (soxC-like) 734722 8191107 METDI0786 Methylobacterium extorquens DM4 putative sulfite oxidase (soxC-like) YP_003066466.1 733379 D 661410 CDS YP_003066467.1 254559372 8191108 734685..735251 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type c : carrier; Cytochrome c, class I precursor 735251 8191108 METDI0787 Methylobacterium extorquens DM4 Cytochrome c, class I precursor YP_003066467.1 734685 D 661410 CDS YP_003066468.1 254559373 8191109 complement(735334..737124) 1 NC_012988.1 catalyzes the formation of acetyl phosphate and sulfite from 2-sulfoacetaldehyde; is active when grown on taurine as a sole carbon source; sulfoacetaldehyde acetyltransferase 737124 xsc 8191109 xsc Methylobacterium extorquens DM4 sulfoacetaldehyde acetyltransferase YP_003066468.1 735334 R 661410 CDS YP_003066469.1 254559374 8196342 737319..738095 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 2185227; Product type r : regulator; DNA-binding transcriptional repressor, IclR family 738095 8196342 METDI0789 Methylobacterium extorquens DM4 DNA-binding transcriptional repressor, IclR family YP_003066469.1 737319 D 661410 CDS YP_003066470.1 254559375 8191110 738133..739317 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative acetate kinase (ackA) 739317 8191110 METDI0790 Methylobacterium extorquens DM4 putative acetate kinase (ackA) YP_003066470.1 738133 D 661410 CDS YP_003066471.1 254559376 8191114 complement(740345..741565) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 741565 8191114 METDI0794 Methylobacterium extorquens DM4 hypothetical protein YP_003066471.1 740345 R 661410 CDS YP_003066472.1 254559377 8191115 complement(741438..742184) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 742184 8191115 METDI0795 Methylobacterium extorquens DM4 hypothetical protein YP_003066472.1 741438 R 661410 CDS YP_003066473.1 254559378 8191116 complement(742072..742692) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 742692 8191116 METDI0796 Methylobacterium extorquens DM4 hypothetical protein YP_003066473.1 742072 R 661410 CDS YP_003066474.1 254559379 8191118 743367..743588 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 743588 8191118 METDI0798 Methylobacterium extorquens DM4 hypothetical protein YP_003066474.1 743367 D 661410 CDS YP_003066475.1 254559380 8191119 complement(743625..743960) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcriptional regulator, XRE family 743960 8191119 METDI0799 Methylobacterium extorquens DM4 putative transcriptional regulator, XRE family YP_003066475.1 743625 R 661410 CDS YP_003066476.1 254559381 8191120 complement(744099..744314) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 744314 8191120 METDI0800 Methylobacterium extorquens DM4 hypothetical protein YP_003066476.1 744099 R 661410 CDS YP_003066477.1 254559382 8191121 complement(744283..744759) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcriptional regulator, XRE family 744759 8191121 METDI0801 Methylobacterium extorquens DM4 putative transcriptional regulator, XRE family YP_003066477.1 744283 R 661410 CDS YP_003066478.1 254559383 8191122 complement(745540..745677) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 745677 8191122 METDI0804 Methylobacterium extorquens DM4 hypothetical protein YP_003066478.1 745540 R 661410 CDS YP_003066479.1 254559384 8191123 complement(745750..745965) 1 NC_012988.1 Evidence 6 : Doubtful CDS; Product type e : enzyme; hypothetical protein 745965 8191123 METDI0805 Methylobacterium extorquens DM4 hypothetical protein YP_003066479.1 745750 R 661410 CDS YP_003066480.1 254559385 8191124 complement(745893..746060) 1 NC_012988.1 Evidence 6 : Doubtful CDS; Product type e : enzyme; hypothetical protein 746060 8191124 METDI0806 Methylobacterium extorquens DM4 hypothetical protein YP_003066480.1 745893 R 661410 CDS YP_003066481.1 254559386 8191125 complement(746343..747782) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 747782 8191125 METDI0807 Methylobacterium extorquens DM4 hypothetical protein YP_003066481.1 746343 R 661410 CDS YP_003066482.1 254559387 8191126 complement(747965..748210) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 748210 8191126 METDI0808 Methylobacterium extorquens DM4 hypothetical protein YP_003066482.1 747965 R 661410 CDS YP_003066483.1 254559388 8191127 complement(748590..748943) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 748943 8191127 METDI0809 Methylobacterium extorquens DM4 hypothetical protein YP_003066483.1 748590 R 661410 CDS YP_003066484.1 254559389 8191128 complement(749765..750043) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 750043 8191128 METDI0810 Methylobacterium extorquens DM4 hypothetical protein YP_003066484.1 749765 R 661410 CDS YP_003066485.1 254559390 8191129 750525..750599 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 750599 8191129 METDI0811 Methylobacterium extorquens DM4 hypothetical protein YP_003066485.1 750525 D 661410 CDS YP_003066486.1 254559391 8191131 complement(751198..751671) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 751671 8191131 METDI0813 Methylobacterium extorquens DM4 hypothetical protein YP_003066486.1 751198 R 661410 CDS YP_003066487.1 254559392 8191132 complement(751638..752219) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 752219 8191132 METDI0814 Methylobacterium extorquens DM4 hypothetical protein YP_003066487.1 751638 R 661410 CDS YP_003066488.1 254559393 8191133 752346..752552 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 752552 8191133 METDI0815 Methylobacterium extorquens DM4 hypothetical protein YP_003066488.1 752346 D 661410 CDS YP_003066489.1 254559394 8191134 complement(752634..752846) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 752846 8191134 METDI0816 Methylobacterium extorquens DM4 hypothetical protein YP_003066489.1 752634 R 661410 CDS YP_003066490.1 254559395 8191135 complement(752863..753267) 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 753267 8191135 METDI0817 Methylobacterium extorquens DM4 hypothetical protein YP_003066490.1 752863 R 661410 CDS YP_003066491.1 254559396 8191136 complement(753180..753401) 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 753401 8191136 METDI0818 Methylobacterium extorquens DM4 hypothetical protein YP_003066491.1 753180 R 661410 CDS YP_003066492.1 254559397 8191137 complement(753702..754718) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 754718 8191137 METDI0819 Methylobacterium extorquens DM4 hypothetical protein YP_003066492.1 753702 R 661410 CDS YP_003066493.1 254559398 8191138 complement(755402..755746) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 755746 8191138 METDI0820 Methylobacterium extorquens DM4 hypothetical protein YP_003066493.1 755402 R 661410 CDS YP_003066494.1 254559399 8191139 complement(756093..756329) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 756329 8191139 METDI0821 Methylobacterium extorquens DM4 hypothetical protein YP_003066494.1 756093 R 661410 CDS YP_003066495.1 254559400 8191140 756692..756940 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 756940 8191140 METDI0822 Methylobacterium extorquens DM4 hypothetical protein YP_003066495.1 756692 D 661410 CDS YP_003066496.1 254559401 8191141 757180..757701 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 757701 8191141 METDI0823 Methylobacterium extorquens DM4 hypothetical protein YP_003066496.1 757180 D 661410 CDS YP_003066497.1 254559402 8196243 complement(759596..760822) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; Oxidoreductase 760822 8196243 METDI0826 Methylobacterium extorquens DM4 Oxidoreductase YP_003066497.1 759596 R 661410 CDS YP_003066498.1 254559403 8191145 761033..761614 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 7678242; Product type pm : putative membrane component; putative membrane protein, putative DedA family protein 761614 8191145 METDI0827 Methylobacterium extorquens DM4 putative membrane protein, putative DedA family protein YP_003066498.1 761033 D 661410 CDS YP_003066499.1 254559404 8191146 761611..762135 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12562793; Product type pe : putative enzyme; putative DsbB-like disulfide oxidoreductase precursor 762135 8191146 METDI0828 Methylobacterium extorquens DM4 putative DsbB-like disulfide oxidoreductase precursor YP_003066499.1 761611 D 661410 CDS YP_003066500.1 254559405 8191147 complement(762099..762716) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 762716 8191147 METDI0829 Methylobacterium extorquens DM4 hypothetical protein YP_003066500.1 762099 R 661410 CDS YP_003066501.1 254559406 8191148 763098..764288 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative Acyltransferase 3 764288 8191148 METDI0830 Methylobacterium extorquens DM4 putative Acyltransferase 3 YP_003066501.1 763098 D 661410 CDS YP_003066502.1 254559407 8191149 complement(764304..764726) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 764726 8191149 METDI0831 Methylobacterium extorquens DM4 hypothetical protein YP_003066502.1 764304 R 661410 CDS YP_003066503.1 254559408 8191150 complement(764828..765853) 1 NC_012988.1 catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate; NAD(P)H-dependent glycerol-3-phosphate dehydrogenase 765853 gpsA 8191150 gpsA Methylobacterium extorquens DM4 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase YP_003066503.1 764828 R 661410 CDS YP_003066504.1 254559409 8195530 766399..767874 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type rc : receptor; methyl-accepting chemotaxis receptor/sensory transducer 767874 8195530 METDI0833 Methylobacterium extorquens DM4 methyl-accepting chemotaxis receptor/sensory transducer YP_003066504.1 766399 D 661410 CDS YP_003066505.1 254559410 8191151 complement(767891..768934) 1 NC_012988.1 in most organisms, only the N-terminal domain is present in a single polypeptide; in some archaea this domain is fused to a kinase domain; this gene is essential for growth in Escherichia coli and Bacillus subtilis; the secreted glycoprotease from Pasteurella haemolytica showed specificity for O-sialoglycosylated proteins; the Pyrococcus structure shows DNA-binding properties, iron-binding, ATP-binding, and AP endonuclease activity; putative DNA-binding/iron metalloprotein/AP endonuclease 768934 ygjD 8191151 ygjD Methylobacterium extorquens DM4 putative DNA-binding/iron metalloprotein/AP endonuclease YP_003066505.1 767891 R 661410 CDS YP_003066506.1 254559411 8196367 769112..769825 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 90104310; Product type pe : putative enzyme; putative uroporphyrinogen III synthase 769825 8196367 METDI0835 Methylobacterium extorquens DM4 putative uroporphyrinogen III synthase YP_003066506.1 769112 D 661410 CDS YP_003066507.1 254559412 8191152 769981..772272 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 772272 8191152 METDI0837 Methylobacterium extorquens DM4 hypothetical protein YP_003066507.1 769981 D 661410 CDS YP_003066508.1 254559413 8191153 772390..773925 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 773925 8191153 METDI0838 Methylobacterium extorquens DM4 hypothetical protein YP_003066508.1 772390 D 661410 CDS YP_003066509.1 254559414 8196262 774239..775594 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative phage integrase 775594 8196262 METDI0840 Methylobacterium extorquens DM4 putative phage integrase YP_003066509.1 774239 D 661410 CDS YP_003066510.1 254559415 8191156 complement(775756..776652) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type r : regulator; LysR family transcriptional regulator 776652 8191156 METDI0842 Methylobacterium extorquens DM4 LysR family transcriptional regulator YP_003066510.1 775756 R 661410 CDS YP_003066511.1 254559416 8191157 776754..777404 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative dinucleotide-binding enzyme oxidoreductase protein precursor 777404 8191157 METDI0843 Methylobacterium extorquens DM4 putative dinucleotide-binding enzyme oxidoreductase protein precursor YP_003066511.1 776754 D 661410 CDS YP_003066512.1 254559417 8191158 777641..778495 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; Zinc-containing alcohol dehydrogenase superfamily 778495 8191158 METDI0844 Methylobacterium extorquens DM4 Zinc-containing alcohol dehydrogenase superfamily YP_003066512.1 777641 D 661410 CDS YP_003066513.1 254559418 8191159 778718..779143 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; transposase of ISMex15, IS5 family (ORF 1) 779143 8191159 METDI0845 Methylobacterium extorquens DM4 transposase of ISMex15, IS5 family (ORF 1) YP_003066513.1 778718 D 661410 CDS YP_003066514.1 254559419 8191160 778918..779472 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; transposase of ISMex15, IS5 family (ORF 2) 779472 8191160 METDI0846 Methylobacterium extorquens DM4 transposase of ISMex15, IS5 family (ORF 2) YP_003066514.1 778918 D 661410 CDS YP_003066515.1 254559420 8191163 780311..781843 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 781843 8191163 METDI0849 Methylobacterium extorquens DM4 hypothetical protein YP_003066515.1 780311 D 661410 CDS YP_003066516.1 254559421 8191164 complement(782110..782730) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative resolvase 782730 8191164 METDI0850 Methylobacterium extorquens DM4 putative resolvase YP_003066516.1 782110 R 661410 CDS YP_003066517.1 254559422 8191165 783114..786200 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type prc : putative receptor; putative diguanylate cyclase (GGDEF) /phosphodiesterase (EAL), with GAF and two PAS/PAC sensor domains 786200 8191165 METDI0851 Methylobacterium extorquens DM4 putative diguanylate cyclase (GGDEF) /phosphodiesterase (EAL), with GAF and two PAS/PAC sensor domains YP_003066517.1 783114 D 661410 CDS YP_003066518.1 254559423 8191167 788351..789493 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 789493 8191167 METDI0853 Methylobacterium extorquens DM4 hypothetical protein YP_003066518.1 788351 D 661410 CDS YP_003066519.1 254559424 8191168 789493..789840 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 789840 8191168 METDI0854 Methylobacterium extorquens DM4 hypothetical protein YP_003066519.1 789493 D 661410 CDS YP_003066520.1 254559425 8191169 789886..790179 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 790179 8191169 METDI0855 Methylobacterium extorquens DM4 hypothetical protein YP_003066520.1 789886 D 661410 CDS YP_003066521.1 254559426 8191170 complement(790298..791377) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 791377 8191170 METDI0856 Methylobacterium extorquens DM4 hypothetical protein YP_003066521.1 790298 R 661410 CDS YP_003066522.1 254559427 8191171 complement(791390..792253) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 792253 8191171 METDI0857 Methylobacterium extorquens DM4 hypothetical protein YP_003066522.1 791390 R 661410 CDS YP_003066523.1 254559428 8191172 793382..794002 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative resolvase 794002 8191172 METDI0858 Methylobacterium extorquens DM4 putative resolvase YP_003066523.1 793382 D 661410 CDS YP_003066524.1 254559429 8191173 complement(794269..795801) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 795801 8191173 METDI0859 Methylobacterium extorquens DM4 hypothetical protein YP_003066524.1 794269 R 661410 CDS YP_003066525.1 254559430 8191175 796201..796521 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 796521 8191175 METDI0861 Methylobacterium extorquens DM4 hypothetical protein YP_003066525.1 796201 D 661410 CDS YP_003066526.1 254559431 8191176 complement(796518..798377) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative resolvase 798377 8191176 METDI0862 Methylobacterium extorquens DM4 putative resolvase YP_003066526.1 796518 R 661410 CDS YP_003066527.1 254559432 8191177 complement(798370..798918) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 798918 8191177 METDI0863 Methylobacterium extorquens DM4 hypothetical protein YP_003066527.1 798370 R 661410 CDS YP_003066528.1 254559433 8191178 complement(798918..799463) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 799463 8191178 METDI0864 Methylobacterium extorquens DM4 hypothetical protein YP_003066528.1 798918 R 661410 CDS YP_003066529.1 254559434 8191179 complement(800026..801039) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; transposase of ISMdi14, IS110 family 801039 8191179 METDI0865 Methylobacterium extorquens DM4 transposase of ISMdi14, IS110 family YP_003066529.1 800026 R 661410 CDS YP_003066530.1 254559435 8191180 complement(801508..802749) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative Multidrug resistance efflux pump 802749 8191180 METDI0866 Methylobacterium extorquens DM4 putative Multidrug resistance efflux pump YP_003066530.1 801508 R 661410 CDS YP_003066531.1 254559436 8191181 complement(802746..803207) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 803207 8191181 METDI0867 Methylobacterium extorquens DM4 hypothetical protein YP_003066531.1 802746 R 661410 CDS YP_003066532.1 254559437 8191182 803483..803908 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; transposase of ISMex15, IS5 family (ORF 1) 803908 8191182 METDI0868 Methylobacterium extorquens DM4 transposase of ISMex15, IS5 family (ORF 1) YP_003066532.1 803483 D 661410 CDS YP_003066533.1 254559438 8191187 complement(806283..806447) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 806447 8191187 METDI0873 Methylobacterium extorquens DM4 hypothetical protein YP_003066533.1 806283 R 661410 CDS YP_003066534.1 254559439 8191188 806343..807155 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcriptional regulator, Crp/Fnr family 807155 8191188 METDI0874 Methylobacterium extorquens DM4 putative transcriptional regulator, Crp/Fnr family YP_003066534.1 806343 D 661410 CDS YP_003066535.1 254559440 8191189 complement(807269..807676) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative response regulator receiver 807676 8191189 METDI0875 Methylobacterium extorquens DM4 putative response regulator receiver YP_003066535.1 807269 R 661410 CDS YP_003066536.1 254559441 8191190 complement(807902..808117) 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 808117 8191190 METDI0876 Methylobacterium extorquens DM4 hypothetical protein YP_003066536.1 807902 R 661410 CDS YP_003066537.1 254559442 8191191 808397..808687 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 808687 8191191 METDI0877 Methylobacterium extorquens DM4 hypothetical protein YP_003066537.1 808397 D 661410 CDS YP_003066538.1 254559443 8191192 complement(808943..809320) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative dioxygenase 809320 8191192 METDI0878 Methylobacterium extorquens DM4 putative dioxygenase YP_003066538.1 808943 R 661410 CDS YP_003066539.1 254559444 8191193 complement(809597..809818) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 809818 8191193 METDI0879 Methylobacterium extorquens DM4 hypothetical protein YP_003066539.1 809597 R 661410 CDS YP_003066540.1 254559445 8191194 810013..810390 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 810390 8191194 METDI0880 Methylobacterium extorquens DM4 hypothetical protein YP_003066540.1 810013 D 661410 CDS YP_003066541.1 254559446 8191195 810458..811858 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative monooxygenase, Cytochrome P450 811858 8191195 METDI0881 Methylobacterium extorquens DM4 putative monooxygenase, Cytochrome P450 YP_003066541.1 810458 D 661410 CDS YP_003066542.1 254559447 8191197 complement(812548..813168) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12207015; Product type pe : putative enzyme; putative 5-formyltetrahydrofolate cyclo-ligase 813168 8191197 METDI0883 Methylobacterium extorquens DM4 putative 5-formyltetrahydrofolate cyclo-ligase YP_003066542.1 812548 R 661410 CDS YP_003066543.1 254559448 8191198 complement(813247..813477) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 813477 8191198 METDI0884 Methylobacterium extorquens DM4 hypothetical protein YP_003066543.1 813247 R 661410 CDS YP_003066544.1 254559449 8191201 complement(814511..814693) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 814693 8191201 METDI0887 Methylobacterium extorquens DM4 hypothetical protein YP_003066544.1 814511 R 661410 CDS YP_003066545.1 254559450 8191202 complement(815198..815455) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 815455 8191202 METDI0888 Methylobacterium extorquens DM4 hypothetical protein YP_003066545.1 815198 R 661410 CDS YP_003066546.1 254559451 8191203 complement(815826..816098) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 816098 8191203 METDI0889 Methylobacterium extorquens DM4 hypothetical protein YP_003066546.1 815826 R 661410 CDS YP_003066547.1 254559452 8191204 complement(817220..817456) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 817456 8191204 METDI0891 Methylobacterium extorquens DM4 hypothetical protein YP_003066547.1 817220 R 661410 CDS YP_003066548.1 254559453 8191205 complement(817453..818583) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcriptional regulator (Crp/Fnr family) with fused CheY-like response receiver and cyclic nucleotide binding domains 818583 8191205 METDI0892 Methylobacterium extorquens DM4 putative transcriptional regulator (Crp/Fnr family) with fused CheY-like response receiver and cyclic nucleotide binding domains YP_003066548.1 817453 R 661410 CDS YP_003066549.1 254559454 8191206 818853..819566 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcriptional regulator, Crp/Fnr family, with N-terminal cNMP-binding domain 819566 8191206 METDI0893 Methylobacterium extorquens DM4 putative transcriptional regulator, Crp/Fnr family, with N-terminal cNMP-binding domain YP_003066549.1 818853 D 661410 CDS YP_003066550.1 254559455 8191207 819566..819826 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 819826 8191207 METDI0894 Methylobacterium extorquens DM4 hypothetical protein YP_003066550.1 819566 D 661410 CDS YP_003066551.1 254559456 8191208 819874..820179 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 820179 8191208 METDI0895 Methylobacterium extorquens DM4 hypothetical protein YP_003066551.1 819874 D 661410 CDS YP_003066552.1 254559457 8191209 complement(820222..820455) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 820455 8191209 METDI0896 Methylobacterium extorquens DM4 hypothetical protein YP_003066552.1 820222 R 661410 CDS YP_003066553.1 254559458 8191210 820768..821478 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcriptional regulator, Crp/Fnr family, with N-terminal cNMP-binding domain 821478 8191210 METDI0897 Methylobacterium extorquens DM4 putative transcriptional regulator, Crp/Fnr family, with N-terminal cNMP-binding domain YP_003066553.1 820768 D 661410 CDS YP_003066554.1 254559459 8191211 821475..821639 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 821639 8191211 METDI0898 Methylobacterium extorquens DM4 hypothetical protein YP_003066554.1 821475 D 661410 CDS YP_003066555.1 254559460 8191212 822134..822856 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcriptional regulator, Crp/Fnr family, with N-terminal cNMP-binding domain 822856 8191212 METDI0899 Methylobacterium extorquens DM4 putative transcriptional regulator, Crp/Fnr family, with N-terminal cNMP-binding domain YP_003066555.1 822134 D 661410 CDS YP_003066556.1 254559461 8191213 822944..823180 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 823180 8191213 METDI0900 Methylobacterium extorquens DM4 hypothetical protein YP_003066556.1 822944 D 661410 CDS YP_003066557.1 254559462 8191214 complement(823210..823392) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 823392 8191214 METDI0901 Methylobacterium extorquens DM4 hypothetical protein YP_003066557.1 823210 R 661410 CDS YP_003066558.1 254559463 8191215 823391..824020 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; DNA integration/recombination/inversion protein, site-specific recombinase, phage integrase family 824020 8191215 METDI0902 Methylobacterium extorquens DM4 DNA integration/recombination/inversion protein, site-specific recombinase, phage integrase family YP_003066558.1 823391 D 661410 CDS YP_003066559.1 254559464 8191216 824567..825550 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type e : enzyme; Sulfatase-modifying factor like (SUMF1-related); putative C-alpha-formyglycine-generating enzyme or methyltransferase or protein kinase 825550 8191216 METDI0903 Methylobacterium extorquens DM4 Sulfatase-modifying factor like (SUMF1-related); putative C-alpha-formyglycine-generating enzyme or methyltransferase or protein kinase YP_003066559.1 824567 D 661410 CDS YP_003066560.1 254559465 8191217 825547..826230 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; Component of arylsulfatase A-related enzymes 826230 8191217 METDI0904 Methylobacterium extorquens DM4 Component of arylsulfatase A-related enzymes YP_003066560.1 825547 D 661410 CDS YP_003066561.1 254559466 8191218 826065..827255 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; Component of arylsulfatase A-related enzyme 827255 8191218 METDI0905 Methylobacterium extorquens DM4 Component of arylsulfatase A-related enzyme YP_003066561.1 826065 D 661410 CDS YP_003066562.1 254559467 8191222 828530..828700 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 828700 8191222 METDI0909 Methylobacterium extorquens DM4 hypothetical protein YP_003066562.1 828530 D 661410 CDS YP_003066563.1 254559468 8191223 828845..829006 1 NC_012988.1 Evidence 6 : Doubtful CDS; Product type e : enzyme; hypothetical protein 829006 8191223 METDI0910 Methylobacterium extorquens DM4 hypothetical protein YP_003066563.1 828845 D 661410 CDS YP_003066564.1 254559469 8191224 829028..829156 1 NC_012988.1 Evidence 6 : Doubtful CDS; Product type e : enzyme; hypothetical protein 829156 8191224 METDI0911 Methylobacterium extorquens DM4 hypothetical protein YP_003066564.1 829028 D 661410 CDS YP_003066565.1 254559470 8191225 829296..829508 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 829508 8191225 METDI0912 Methylobacterium extorquens DM4 hypothetical protein YP_003066565.1 829296 D 661410 CDS YP_003066566.1 254559471 8191226 829812..831701 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative histidine kinase of the HWE family 831701 8191226 METDI0914 Methylobacterium extorquens DM4 putative histidine kinase of the HWE family YP_003066566.1 829812 D 661410 CDS YP_003066567.1 254559472 8191227 831830..832060 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 832060 8191227 METDI0915 Methylobacterium extorquens DM4 hypothetical protein YP_003066567.1 831830 D 661410 CDS YP_003066568.1 254559473 8191228 complement(832770..833717) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; Zinc-containing alcohol dehydrogenase superfamily 833717 8191228 METDI0918 Methylobacterium extorquens DM4 Zinc-containing alcohol dehydrogenase superfamily YP_003066568.1 832770 R 661410 CDS YP_003066569.1 254559474 8191229 833864..834748 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8843437; Product type pr : putative regulator; putative transcriptional regulator, LysR family 834748 8191229 METDI0919 Methylobacterium extorquens DM4 putative transcriptional regulator, LysR family YP_003066569.1 833864 D 661410 CDS YP_003066570.1 254559475 8191230 834749..834979 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 834979 8191230 METDI0920 Methylobacterium extorquens DM4 hypothetical protein YP_003066570.1 834749 D 661410 CDS YP_003066571.1 254559476 8191234 complement(836222..839419) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative sensor hybrid histidine kinase with multiple PAS/PAC and response regulator receiver domains 839419 8191234 METDI0924 Methylobacterium extorquens DM4 putative sensor hybrid histidine kinase with multiple PAS/PAC and response regulator receiver domains YP_003066571.1 836222 R 661410 CDS YP_003066572.1 254559477 8191235 complement(839688..840242) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; transposase of ISMex15, IS5 family (ORF 2) 840242 8191235 METDI0925 Methylobacterium extorquens DM4 transposase of ISMex15, IS5 family (ORF 2) YP_003066572.1 839688 R 661410 CDS YP_003066573.1 254559478 8191236 complement(840017..840442) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; transposase of ISMex15, IS5 family (ORF 1) 840442 8191236 METDI0926 Methylobacterium extorquens DM4 transposase of ISMex15, IS5 family (ORF 1) YP_003066573.1 840017 R 661410 CDS YP_003066574.1 254559479 8191237 841897..842826 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type e : enzyme; transposase of ISMdi4, IS481 family 842826 8191237 METDI0927 Methylobacterium extorquens DM4 transposase of ISMdi4, IS481 family YP_003066574.1 841897 D 661410 CDS YP_003066575.1 254559480 8191238 complement(842839..843006) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 843006 8191238 METDI0928 Methylobacterium extorquens DM4 hypothetical protein YP_003066575.1 842839 R 661410 CDS YP_003066576.1 254559481 8191240 complement(843399..844304) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 14704707; Product type e : enzyme; putative Coenzyme B12-binding 844304 8191240 METDI0930 Methylobacterium extorquens DM4 putative Coenzyme B12-binding YP_003066576.1 843399 R 661410 CDS YP_003066577.1 254559482 8191241 complement(844482..844655) 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 844655 8191241 METDI0931 Methylobacterium extorquens DM4 hypothetical protein YP_003066577.1 844482 R 661410 CDS YP_003066578.1 254559483 8191242 844735..845010 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 845010 8191242 METDI0932 Methylobacterium extorquens DM4 hypothetical protein YP_003066578.1 844735 D 661410 CDS YP_003066579.1 254559484 8191243 complement(845213..846670) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative phage uncharacterized protein 846670 8191243 METDI0933 Methylobacterium extorquens DM4 putative phage uncharacterized protein YP_003066579.1 845213 R 661410 CDS YP_003066580.1 254559485 8191244 complement(846682..847236) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 847236 8191244 METDI0934 Methylobacterium extorquens DM4 hypothetical protein YP_003066580.1 846682 R 661410 CDS YP_003066581.1 254559486 8191245 complement(847229..848713) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative phage methyltransferase 848713 8191245 METDI0935 Methylobacterium extorquens DM4 putative phage methyltransferase YP_003066581.1 847229 R 661410 CDS YP_003066582.1 254559487 8191246 849607..849888 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 849888 8191246 METDI0936 Methylobacterium extorquens DM4 hypothetical protein YP_003066582.1 849607 D 661410 CDS YP_003066583.1 254559488 8191247 complement(849919..850149) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 850149 8191247 METDI0937 Methylobacterium extorquens DM4 hypothetical protein YP_003066583.1 849919 R 661410 CDS YP_003066584.1 254559489 8191248 850808..852772 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 9163424; Product type prc : putative receptor; putative chemoreceptor y4sI (Methyl-accepting chemotaxis protein) 852772 8191248 METDI0938 Methylobacterium extorquens DM4 putative chemoreceptor y4sI (Methyl-accepting chemotaxis protein) YP_003066584.1 850808 D 661410 CDS YP_003066585.1 254559490 8191249 852896..853546 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 853546 8191249 METDI0939 Methylobacterium extorquens DM4 hypothetical protein YP_003066585.1 852896 D 661410 CDS YP_003066586.1 254559491 8191250 complement(853901..854092) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 854092 8191250 METDI0940 Methylobacterium extorquens DM4 hypothetical protein YP_003066586.1 853901 R 661410 CDS YP_003066587.1 254559492 8191251 854266..854466 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 854466 8191251 METDI0941 Methylobacterium extorquens DM4 hypothetical protein YP_003066587.1 854266 D 661410 CDS YP_003066588.1 254559493 8191252 854618..856762 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 856762 8191252 METDI0942 Methylobacterium extorquens DM4 hypothetical protein YP_003066588.1 854618 D 661410 CDS YP_003066589.1 254559494 8196085 863237..863554 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 863554 8196085 METDI0948 Methylobacterium extorquens DM4 hypothetical protein YP_003066589.1 863237 D 661410 CDS YP_003066590.1 254559495 8191254 863804..866119 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 8755871; Product type f : factor; transcriptional accessory protein 866119 8191254 METDI0949 Methylobacterium extorquens DM4 transcriptional accessory protein YP_003066590.1 863804 D 661410 CDS YP_003066591.1 254559496 8191255 complement(866106..866426) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 866426 8191255 METDI0950 Methylobacterium extorquens DM4 hypothetical protein YP_003066591.1 866106 R 661410 CDS YP_003066592.1 254559497 8191256 866974..867627 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type t : transporter; ATP-binding protein 867627 8191256 METDI0951 Methylobacterium extorquens DM4 ATP-binding protein YP_003066592.1 866974 D 661410 CDS YP_003066593.1 254559498 8191257 867777..869021 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; putative Capsule polysaccharide export inner-membrane protein 869021 8191257 METDI0952 Methylobacterium extorquens DM4 putative Capsule polysaccharide export inner-membrane protein YP_003066593.1 867777 D 661410 CDS YP_003066594.1 254559499 8191258 complement(869030..869746) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 869746 8191258 METDI0953 Methylobacterium extorquens DM4 hypothetical protein YP_003066594.1 869030 R 661410 CDS YP_003066595.1 254559500 8191259 complement(869783..870091) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 870091 8191259 METDI0954 Methylobacterium extorquens DM4 hypothetical protein YP_003066595.1 869783 R 661410 CDS YP_003066596.1 254559501 8191260 870292..872433 1 NC_012988.1 membrane protein involved in the flagellar export apparatus; flagellar biosynthesis protein FlhA 872433 flhA 8191260 flhA Methylobacterium extorquens DM4 flagellar biosynthesis protein FlhA YP_003066596.1 870292 D 661410 CDS YP_003066597.1 254559502 8195410 872689..874365 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative methyl-accepting chemotaxis receptor/sensory transducer 874365 8195410 METDI0956 Methylobacterium extorquens DM4 putative methyl-accepting chemotaxis receptor/sensory transducer YP_003066597.1 872689 D 661410 CDS YP_003066598.1 254559503 8191261 complement(874516..874656) 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 874656 8191261 METDI0957 Methylobacterium extorquens DM4 hypothetical protein YP_003066598.1 874516 R 661410 CDS YP_003066599.1 254559504 8191262 complement(874889..875941) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 875941 8191262 METDI0958 Methylobacterium extorquens DM4 hypothetical protein YP_003066599.1 874889 R 661410 CDS YP_003066600.1 254559505 8191263 complement(876298..876702) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 876702 8191263 METDI0959 Methylobacterium extorquens DM4 hypothetical protein YP_003066600.1 876298 R 661410 CDS YP_003066601.1 254559506 8191264 complement(876798..878153) 1 NC_012988.1 involved in type III protein export during flagellum assembly; flagellum-specific ATP synthase 878153 fliI 8191264 fliI Methylobacterium extorquens DM4 flagellum-specific ATP synthase YP_003066601.1 876798 R 661410 CDS YP_003066602.1 254559507 8195420 878592..879293 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 11259647, 8548829, 9465034; Product type r : regulator; Cell cycle transcriptional regulator ctrA (Response regulator sokA) 879293 ctrA 8195420 ctrA Methylobacterium extorquens DM4 Cell cycle transcriptional regulator ctrA (Response regulator sokA) YP_003066602.1 878592 D 661410 CDS YP_003066603.1 254559508 8195227 complement(879405..879908) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 879908 8195227 METDI0962 Methylobacterium extorquens DM4 hypothetical protein YP_003066603.1 879405 R 661410 CDS YP_003066604.1 254559509 8191265 complement(880001..880252) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 880252 8191265 METDI0963 Methylobacterium extorquens DM4 hypothetical protein YP_003066604.1 880001 R 661410 CDS YP_003066605.1 254559510 8191266 complement(880286..880960) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8540711; Product type pe : putative enzyme; putative acetyltransferase 880960 8191266 METDI0964 Methylobacterium extorquens DM4 putative acetyltransferase YP_003066605.1 880286 R 661410 CDS YP_003066606.1 254559511 8191267 880988..883321 1 NC_012988.1 NADP-dependent; catalyzes the oxidative decarboxylation of malate to form pyruvate; decarboxylates oxaloacetate; malic enzyme 883321 dme 8191267 dme Methylobacterium extorquens DM4 malic enzyme YP_003066606.1 880988 D 661410 CDS YP_003066607.1 254559512 8195299 883424..884863 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 12694921; hypothetical protein 884863 8195299 METDI0966 Methylobacterium extorquens DM4 hypothetical protein YP_003066607.1 883424 D 661410 CDS YP_003066608.1 254559513 8191268 complement(885035..885214) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 885214 8191268 METDI0967 Methylobacterium extorquens DM4 hypothetical protein YP_003066608.1 885035 R 661410 CDS YP_003066609.1 254559514 8191269 complement(885293..886177) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 886177 8191269 METDI0968 Methylobacterium extorquens DM4 hypothetical protein YP_003066609.1 885293 R 661410 CDS YP_003066610.1 254559515 8191270 complement(886174..888249) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative glycosyl transferase 888249 8191270 METDI0969 Methylobacterium extorquens DM4 putative glycosyl transferase YP_003066610.1 886174 R 661410 CDS YP_003066611.1 254559516 8191271 complement(888253..890277) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 890277 8191271 METDI0970 Methylobacterium extorquens DM4 hypothetical protein YP_003066611.1 888253 R 661410 CDS YP_003066612.1 254559517 8191272 complement(890274..890963) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 890963 8191272 METDI0971 Methylobacterium extorquens DM4 hypothetical protein YP_003066612.1 890274 R 661410 CDS YP_003066613.1 254559518 8191273 complement(891159..892544) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; hypothetical protein 892544 8191273 METDI0972 Methylobacterium extorquens DM4 hypothetical protein YP_003066613.1 891159 R 661410 CDS YP_003066614.1 254559519 8191274 892833..893357 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; oxidoreductase, 2Fe-2S subunit 893357 8191274 METDI0973 Methylobacterium extorquens DM4 oxidoreductase, 2Fe-2S subunit YP_003066614.1 892833 D 661410 CDS YP_003066615.1 254559520 8191275 893354..894370 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; oxidoreductase, FAD-binding subunit; putative molybdopterin oxidoreductase, xanthine dehydrogenase family 894370 8191275 METDI0974 Methylobacterium extorquens DM4 oxidoreductase, FAD-binding subunit; putative molybdopterin oxidoreductase, xanthine dehydrogenase family YP_003066615.1 893354 D 661410 CDS YP_003066616.1 254559521 8191276 894380..896641 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; oxidoreductase, molybdopterin-binding subunit 896641 8191276 METDI0975 Methylobacterium extorquens DM4 oxidoreductase, molybdopterin-binding subunit YP_003066616.1 894380 D 661410 CDS YP_003066617.1 254559522 8191277 896918..897286 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 11545279; Product type m : membrane component; integral membrane protein precursor; putative CrcB protein 897286 8191277 METDI0976 Methylobacterium extorquens DM4 integral membrane protein precursor; putative CrcB protein YP_003066617.1 896918 D 661410 CDS YP_003066618.1 254559523 8191278 897283..897735 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 897735 8191278 METDI0977 Methylobacterium extorquens DM4 hypothetical protein YP_003066618.1 897283 D 661410 CDS YP_003066619.1 254559524 8191279 897735..898397 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 9687406, 9736537; Product type e : enzyme; D-alanyl-D-alanine dipeptidase 898397 8191279 METDI0978 Methylobacterium extorquens DM4 D-alanyl-D-alanine dipeptidase YP_003066619.1 897735 D 661410 CDS YP_003066620.1 254559525 8191280 898566..898841 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 898841 8191280 METDI0979 Methylobacterium extorquens DM4 hypothetical protein YP_003066620.1 898566 D 661410 CDS YP_003066621.1 254559526 8191281 898838..899164 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 899164 8191281 METDI0980 Methylobacterium extorquens DM4 hypothetical protein YP_003066621.1 898838 D 661410 CDS YP_003066622.1 254559527 8191282 complement(899282..899923) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcriptional regulator, MarR family 899923 8191282 METDI0981 Methylobacterium extorquens DM4 putative transcriptional regulator, MarR family YP_003066622.1 899282 R 661410 CDS YP_003066623.1 254559528 8191283 900170..902347 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative glycosyl transferase 902347 8191283 METDI0982 Methylobacterium extorquens DM4 putative glycosyl transferase YP_003066623.1 900170 D 661410 CDS YP_003066624.1 254559529 8191284 902379..903146 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; alpha-D-glucose-1-phosphate cytidylyltransferase 903146 rfbF 8191284 rfbF Methylobacterium extorquens DM4 alpha-D-glucose-1-phosphate cytidylyltransferase YP_003066624.1 902379 D 661410 CDS YP_003066625.1 254559530 8195985 903146..904252 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; cdp-glucose 4,6-dehydratase 904252 rfbG 8195985 rfbG Methylobacterium extorquens DM4 cdp-glucose 4,6-dehydratase YP_003066625.1 903146 D 661410 CDS YP_003066626.1 254559531 8195986 904249..905478 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type e : enzyme; putative Methyltransferase 905478 8195986 METDI0985 Methylobacterium extorquens DM4 putative Methyltransferase YP_003066626.1 904249 D 661410 CDS YP_003066627.1 254559532 8191285 905663..906196 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 1710759; Product type e : enzyme; dTDP-4-dehydrorhamnose 3,5-epimerase 906196 rfbC 8191285 rfbC Methylobacterium extorquens DM4 dTDP-4-dehydrorhamnose 3,5-epimerase YP_003066627.1 905663 D 661410 CDS YP_003066628.1 254559533 8195982 906193..907233 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative CDP-4-dehydro-6-deoxy-D-gulose 4-reductase 907233 8195982 METDI0987 Methylobacterium extorquens DM4 putative CDP-4-dehydro-6-deoxy-D-gulose 4-reductase YP_003066628.1 906193 D 661410 CDS YP_003066629.1 254559534 8191286 complement(907208..907606) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative response regulator receiver 907606 8191286 METDI0988 Methylobacterium extorquens DM4 putative response regulator receiver YP_003066629.1 907208 R 661410 CDS YP_003066630.1 254559535 8191287 complement(907858..909108) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; 7,8-diaminopelargonic acid synthetase, PLP-dependent (Adenosylmethionine-8-amino-7-oxononanoate aminotransferase) 909108 bioA 8191287 bioA Methylobacterium extorquens DM4 7,8-diaminopelargonic acid synthetase, PLP-dependent (Adenosylmethionine-8-amino-7-oxononanoate aminotransferase) YP_003066630.1 907858 R 661410 CDS YP_003066631.1 254559536 8195141 complement(909305..912151) 1 NC_012988.1 acts in conjunction with GvcH to form H-protein-S-aminomethyldihydrolipoyllysine from glycine; glycine dehydrogenase 912151 gcvP 8195141 gcvP Methylobacterium extorquens DM4 glycine dehydrogenase YP_003066631.1 909305 R 661410 CDS YP_003066632.1 254559537 8195476 complement(912325..912687) 1 NC_012988.1 part of multienzyme complex composed of H, L, P, and T proteins which catalyzes oxidation of glycine to yield carbon dioxide, ammonia, 5,10-CH2-H4folate and a reduced pyridine nucleotide; protein H is involved in transfer of methylamine group from the P to T protein; covalently bound to a lipoyl cofactor; glycine cleavage system protein H 912687 gcvH 8195476 gcvH Methylobacterium extorquens DM4 glycine cleavage system protein H YP_003066632.1 912325 R 661410 CDS YP_003066633.1 254559538 8195475 complement(912714..913901) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; glycine cleavage complex protein T, aminomethyltransferase, tetrahydrofolate-dependent 913901 gcvT 8195475 gcvT Methylobacterium extorquens DM4 glycine cleavage complex protein T, aminomethyltransferase, tetrahydrofolate-dependent YP_003066633.1 912714 R 661410 CDS YP_003066634.1 254559539 8195040 complement(914210..914440) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 914440 8195040 METDI0993 Methylobacterium extorquens DM4 hypothetical protein YP_003066634.1 914210 R 661410 CDS YP_003066635.1 254559540 8191288 914547..915698 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; 7-keto-8-aminopelargonic acid synthetase (8-amino-7-oxononanoate synthase 915698 bioF 8191288 bioF Methylobacterium extorquens DM4 7-keto-8-aminopelargonic acid synthetase (8-amino-7-oxononanoate synthase YP_003066635.1 914547 D 661410 CDS YP_003066636.1 254559541 8195145 complement(915705..916565) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 916565 8195145 METDI0995 Methylobacterium extorquens DM4 hypothetical protein YP_003066636.1 915705 R 661410 CDS YP_003066637.1 254559542 8191289 916943..917248 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 917248 8191289 METDI0997 Methylobacterium extorquens DM4 hypothetical protein YP_003066637.1 916943 D 661410 CDS YP_003066638.1 254559543 8191290 complement(917308..917994) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; Short-chain dehydrogenase/reductase SDR 917994 8191290 METDI0998 Methylobacterium extorquens DM4 Short-chain dehydrogenase/reductase SDR YP_003066638.1 917308 R 661410 CDS YP_003066639.1 254559544 8191291 complement(918057..918773) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative MgtC-magnesium transport 918773 8191291 METDI0999 Methylobacterium extorquens DM4 putative MgtC-magnesium transport YP_003066639.1 918057 R 661410 CDS YP_003066640.1 254559545 8191292 919065..920057 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8997703; Product type pe : putative enzyme; putative ATPase, MoxR-like protein 920057 8191292 METDI1000 Methylobacterium extorquens DM4 putative ATPase, MoxR-like protein YP_003066640.1 919065 D 661410 CDS YP_003066641.1 254559546 8191293 920063..920992 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 920992 8191293 METDI1001 Methylobacterium extorquens DM4 hypothetical protein YP_003066641.1 920063 D 661410 CDS YP_003066642.1 254559547 8191294 921161..921622 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 921622 8191294 METDI1002 Methylobacterium extorquens DM4 hypothetical protein YP_003066642.1 921161 D 661410 CDS YP_003066643.1 254559548 8191295 921628..922647 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 922647 8191295 METDI1003 Methylobacterium extorquens DM4 hypothetical protein YP_003066643.1 921628 D 661410 CDS YP_003066644.1 254559549 8191296 922659..923582 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 923582 8191296 METDI1004 Methylobacterium extorquens DM4 hypothetical protein YP_003066644.1 922659 D 661410 CDS YP_003066645.1 254559550 8191297 923582..924520 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 924520 8191297 METDI1005 Methylobacterium extorquens DM4 hypothetical protein YP_003066645.1 923582 D 661410 CDS YP_003066646.1 254559551 8191298 924520..925836 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 925836 8191298 METDI1006 Methylobacterium extorquens DM4 hypothetical protein YP_003066646.1 924520 D 661410 CDS YP_003066647.1 254559552 8191299 925924..927018 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 16926146; hypothetical protein 927018 8191299 METDI1007 Methylobacterium extorquens DM4 hypothetical protein YP_003066647.1 925924 D 661410 CDS YP_003066648.1 254559553 8191300 927170..928111 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 928111 8191300 METDI1008 Methylobacterium extorquens DM4 hypothetical protein YP_003066648.1 927170 D 661410 CDS YP_003066649.1 254559554 8191301 928077..928556 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 928556 8191301 METDI1009 Methylobacterium extorquens DM4 hypothetical protein YP_003066649.1 928077 D 661410 CDS YP_003066650.1 254559555 8191302 complement(928122..928412) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 928412 8191302 METDI1010 Methylobacterium extorquens DM4 hypothetical protein YP_003066650.1 928122 R 661410 CDS YP_003066651.1 254559556 8191303 complement(928681..929736) 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 929736 8191303 METDI1011 Methylobacterium extorquens DM4 hypothetical protein YP_003066651.1 928681 R 661410 CDS YP_003066652.1 254559557 8191304 complement(929982..930398) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; methionine sulfoxide reductase (Peptide-methionine (R)-S-oxide reductase) 930398 msrB 8191304 msrB Methylobacterium extorquens DM4 methionine sulfoxide reductase (Peptide-methionine (R)-S-oxide reductase) YP_003066652.1 929982 R 661410 CDS YP_003066653.1 254559558 8195729 complement(930502..931668) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; Ribonuclease BN 931668 rbn2 8195729 rbn2 Methylobacterium extorquens DM4 Ribonuclease BN YP_003066653.1 930502 R 661410 CDS YP_003066654.1 254559559 8195966 complement(931801..933267) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative sensory transduction histidine kinase 933267 8195966 METDI1014 Methylobacterium extorquens DM4 putative sensory transduction histidine kinase YP_003066654.1 931801 R 661410 CDS YP_003066655.1 254559560 8191305 complement(933471..935003) 1 NC_012988.1 catalyzes the formation of malonyl-CoA from malonate and CoA; malonyl-CoA synthase 935003 matB 8191305 matB Methylobacterium extorquens DM4 malonyl-CoA synthase YP_003066655.1 933471 R 661410 CDS YP_003066656.1 254559561 8195663 complement(935147..935587) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 935587 8195663 METDI1016 Methylobacterium extorquens DM4 hypothetical protein YP_003066656.1 935147 R 661410 CDS YP_003066657.1 254559562 8191306 935941..936834 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 936834 8191306 METDI1017 Methylobacterium extorquens DM4 hypothetical protein YP_003066657.1 935941 D 661410 CDS YP_003066658.1 254559563 8191307 complement(936847..938070) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 938070 8191307 METDI1018 Methylobacterium extorquens DM4 hypothetical protein YP_003066658.1 936847 R 661410 CDS YP_003066659.1 254559564 8191308 938385..939410 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 939410 8191308 METDI1019 Methylobacterium extorquens DM4 hypothetical protein YP_003066659.1 938385 D 661410 CDS YP_003066660.1 254559565 8191309 939552..939854 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 939854 8191309 METDI1020 Methylobacterium extorquens DM4 hypothetical protein YP_003066660.1 939552 D 661410 CDS YP_003066661.1 254559566 8191310 complement(939931..940509) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 16926146, 17933887, 8626329; Product type e : enzyme; General stress protein, putative intracellular proteinase 940509 pfpI 8191310 pfpI Methylobacterium extorquens DM4 General stress protein, putative intracellular proteinase YP_003066661.1 939931 R 661410 CDS YP_003066662.1 254559567 8195848 940693..940914 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 940914 8195848 METDI1022 Methylobacterium extorquens DM4 hypothetical protein YP_003066662.1 940693 D 661410 CDS YP_003066663.1 254559568 8191311 941090..941524 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 941524 8191311 METDI1024 Methylobacterium extorquens DM4 hypothetical protein YP_003066663.1 941090 D 661410 CDS YP_003066664.1 254559569 8191312 complement(941583..941972) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 941972 8191312 METDI1025 Methylobacterium extorquens DM4 hypothetical protein YP_003066664.1 941583 R 661410 CDS YP_003066665.1 254559570 8191313 942318..942527 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type f : factor; major cold shock protein 942527 cspA 8191313 cspA Methylobacterium extorquens DM4 major cold shock protein YP_003066665.1 942318 D 661410 CDS YP_003066666.1 254559571 8195222 942735..942962 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 942962 8195222 METDI1027 Methylobacterium extorquens DM4 hypothetical protein YP_003066666.1 942735 D 661410 CDS YP_003066667.1 254559572 8191314 complement(943132..943572) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 943572 8191314 METDI1028 Methylobacterium extorquens DM4 hypothetical protein YP_003066667.1 943132 R 661410 CDS YP_003066668.1 254559573 8191315 complement(943676..944875) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 944875 8191315 METDI1029 Methylobacterium extorquens DM4 hypothetical protein YP_003066668.1 943676 R 661410 CDS YP_003066669.1 254559574 8191316 945044..946249 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative transporter, major facilitator superfamily 946249 8191316 METDI1030 Methylobacterium extorquens DM4 putative transporter, major facilitator superfamily YP_003066669.1 945044 D 661410 CDS YP_003066670.1 254559575 8191317 946433..947581 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 17369300; Product type pt : putative transporter; putative ABC transporter, permease 947581 8191317 METDI1031 Methylobacterium extorquens DM4 putative ABC transporter, permease YP_003066670.1 946433 D 661410 CDS YP_003066671.1 254559576 8191318 947678..948451 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative ABC transporter, ATPase 948451 8191318 METDI1032 Methylobacterium extorquens DM4 putative ABC transporter, ATPase YP_003066671.1 947678 D 661410 CDS YP_003066672.1 254559577 8191319 948523..949605 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative ABC transporter, periplasmic protein 949605 8191319 METDI1033 Methylobacterium extorquens DM4 putative ABC transporter, periplasmic protein YP_003066672.1 948523 D 661410 CDS YP_003066673.1 254559578 8191320 949726..950349 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative uncharacterized ABC-transporter auxiliary component 950349 8191320 METDI1034 Methylobacterium extorquens DM4 putative uncharacterized ABC-transporter auxiliary component YP_003066673.1 949726 D 661410 CDS YP_003066674.1 254559579 8191321 complement(950401..951219) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10747806, 8002619; Product type pe : putative enzyme; putative inositol monophosphatase (suhB-like) 951219 8191321 METDI1035 Methylobacterium extorquens DM4 putative inositol monophosphatase (suhB-like) YP_003066674.1 950401 R 661410 CDS YP_003066675.1 254559580 8191322 951585..952085 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 952085 8191322 METDI1037 Methylobacterium extorquens DM4 hypothetical protein YP_003066675.1 951585 D 661410 CDS YP_003066676.1 254559581 8191323 complement(952206..952394) 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 952394 8191323 METDI1038 Methylobacterium extorquens DM4 hypothetical protein YP_003066676.1 952206 R 661410 CDS YP_003066677.1 254559582 8191324 complement(952438..953388) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; p-hydroxybenzoate octaprenyltransferase 953388 ubiA 8191324 ubiA Methylobacterium extorquens DM4 p-hydroxybenzoate octaprenyltransferase YP_003066677.1 952438 R 661410 CDS YP_003066678.1 254559583 8196293 complement(953424..954026) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 954026 8196293 METDI1040 Methylobacterium extorquens DM4 hypothetical protein YP_003066678.1 953424 R 661410 CDS YP_003066679.1 254559584 8191325 954334..955086 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 955086 8191325 METDI1041 Methylobacterium extorquens DM4 hypothetical protein YP_003066679.1 954334 D 661410 CDS YP_003066680.1 254559585 8191326 955116..956099 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative L-asparaginase (ansA-like) 956099 8191326 METDI1042 Methylobacterium extorquens DM4 putative L-asparaginase (ansA-like) YP_003066680.1 955116 D 661410 CDS YP_003066681.1 254559586 8191327 956286..957656 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 9807829; Product type e : enzyme; gamma-glutamylcysteine synthetase 957656 gshA 8191327 gshA Methylobacterium extorquens DM4 gamma-glutamylcysteine synthetase YP_003066681.1 956286 D 661410 CDS YP_003066682.1 254559587 8195537 957768..958178 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 958178 8195537 METDI1044 Methylobacterium extorquens DM4 hypothetical protein YP_003066682.1 957768 D 661410 CDS YP_003066683.1 254559588 8191328 958258..958524 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative sulfurtransferase tusA 958524 8191328 METDI1045 Methylobacterium extorquens DM4 putative sulfurtransferase tusA YP_003066683.1 958258 D 661410 CDS YP_003066684.1 254559589 8191329 958564..959130 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative NUDIX hydrolase 959130 8191329 METDI1046 Methylobacterium extorquens DM4 putative NUDIX hydrolase YP_003066684.1 958564 D 661410 CDS YP_003066685.1 254559590 8191330 959587..959985 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 959985 8191330 METDI1047 Methylobacterium extorquens DM4 hypothetical protein YP_003066685.1 959587 D 661410 CDS YP_003066686.1 254559591 8191331 complement(960135..960575) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 960575 8191331 METDI1048 Methylobacterium extorquens DM4 hypothetical protein YP_003066686.1 960135 R 661410 CDS YP_003066687.1 254559592 8191332 complement(960821..961522) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 961522 8191332 METDI1050 Methylobacterium extorquens DM4 hypothetical protein YP_003066687.1 960821 R 661410 CDS YP_003066688.1 254559593 8191333 complement(961510..961722) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 961722 8191333 METDI1051 Methylobacterium extorquens DM4 hypothetical protein YP_003066688.1 961510 R 661410 CDS YP_003066689.1 254559594 8191334 complement(961777..962454) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 962454 8191334 METDI1052 Methylobacterium extorquens DM4 hypothetical protein YP_003066689.1 961777 R 661410 CDS YP_003066690.1 254559595 8191335 complement(962469..963296) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 96062218; Product type e : enzyme; Cobalamin synthase 963296 cobS 8191335 cobS Methylobacterium extorquens DM4 Cobalamin synthase YP_003066690.1 962469 R 661410 CDS YP_003066691.1 254559596 8195196 963464..964501 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 96062218; Product type e : enzyme; Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase (NN:DBI PRT) (N(1)-alpha-phosphoribosyltransferase) 964501 cobT 8195196 cobT Methylobacterium extorquens DM4 Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase (NN:DBI PRT) (N(1)-alpha-phosphoribosyltransferase) YP_003066691.1 963464 D 661410 CDS YP_003066692.1 254559597 8195198 complement(964555..966096) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative integral membrane sensor signal transduction histidine kinase 966096 8195198 METDI1055 Methylobacterium extorquens DM4 putative integral membrane sensor signal transduction histidine kinase YP_003066692.1 964555 R 661410 CDS YP_003066693.1 254559598 8191336 966439..966894 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type e : enzyme; putative aldehyde oxidase, xanthine dehydrogenase family, Fe-S subunit 966894 8191336 METDI1056 Methylobacterium extorquens DM4 putative aldehyde oxidase, xanthine dehydrogenase family, Fe-S subunit YP_003066693.1 966439 D 661410 CDS YP_003066694.1 254559599 8191337 966891..969125 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative aldehyde dehydrogenase precursor (tat pathway signal) 969125 8191337 METDI1057 Methylobacterium extorquens DM4 putative aldehyde dehydrogenase precursor (tat pathway signal) YP_003066694.1 966891 D 661410 CDS YP_003066695.1 254559600 8191338 969305..972703 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative sensory histidine kinase, putative methyltransferase, putative sensory_box: PAS domain S-box domain 972703 8191338 METDI1058 Methylobacterium extorquens DM4 putative sensory histidine kinase, putative methyltransferase, putative sensory_box: PAS domain S-box domain YP_003066695.1 969305 D 661410 CDS YP_003066696.1 254559601 8191339 complement(972791..974032) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 12597275; Product type e : enzyme; Amidase 974032 8191339 METDI1059 Methylobacterium extorquens DM4 Amidase YP_003066696.1 972791 R 661410 CDS YP_003066697.1 254559602 8191340 974140..975129 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 975129 8191340 METDI1060 Methylobacterium extorquens DM4 hypothetical protein YP_003066697.1 974140 D 661410 CDS YP_003066698.1 254559603 8191341 975310..975777 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 975777 8191341 METDI1061 Methylobacterium extorquens DM4 hypothetical protein YP_003066698.1 975310 D 661410 CDS YP_003066699.1 254559604 8191342 975877..976551 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 2253883, 8188249, 90151658, 90264307; Product type e : enzyme; Ribonuclease T2 976551 8191342 METDI1062 Methylobacterium extorquens DM4 Ribonuclease T2 YP_003066699.1 975877 D 661410 CDS YP_003066700.1 254559605 8191343 977029..977835 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative DNA (exogenous) processing protein, yhiR 977835 8191343 METDI1063 Methylobacterium extorquens DM4 putative DNA (exogenous) processing protein, yhiR YP_003066700.1 977029 D 661410 CDS YP_003066701.1 254559606 8191344 complement(977852..978121) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 978121 8191344 METDI1064 Methylobacterium extorquens DM4 hypothetical protein YP_003066701.1 977852 R 661410 CDS YP_003066702.1 254559607 8191345 complement(978136..978366) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 978366 8191345 METDI1065 Methylobacterium extorquens DM4 hypothetical protein YP_003066702.1 978136 R 661410 CDS YP_003066703.1 254559608 8191346 complement(978472..979905) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 96178972; Product type pe : putative enzyme; putative glycolate oxidase (glcD-like), FAD-linked subunit 979905 8191346 METDI1066 Methylobacterium extorquens DM4 putative glycolate oxidase (glcD-like), FAD-linked subunit YP_003066703.1 978472 R 661410 CDS YP_003066704.1 254559609 8191347 980220..980582 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 221822; Product type c : carrier; Cytochrome c2 precursor 980582 cycA 8191347 cycA Methylobacterium extorquens DM4 Cytochrome c2 precursor YP_003066704.1 980220 D 661410 CDS YP_003066705.1 254559610 8195234 complement(980679..981164) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type r : regulator; transcriptional regulator, MarR family 981164 8195234 METDI1068 Methylobacterium extorquens DM4 transcriptional regulator, MarR family YP_003066705.1 980679 R 661410 CDS YP_003066706.1 254559611 8191348 complement(981710..982315) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 982315 8191348 METDI1069 Methylobacterium extorquens DM4 hypothetical protein YP_003066706.1 981710 R 661410 CDS YP_003066707.1 254559612 8191349 complement(982315..983055) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 983055 8191349 METDI1070 Methylobacterium extorquens DM4 hypothetical protein YP_003066707.1 982315 R 661410 CDS YP_003066708.1 254559613 8191350 complement(983066..985363) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 14704707; Product type pe : putative enzyme; putative penicillin-binding protein 985363 8191350 METDI1071 Methylobacterium extorquens DM4 putative penicillin-binding protein YP_003066708.1 983066 R 661410 CDS YP_003066709.1 254559614 8191351 985674..986138 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 986138 8191351 METDI1072 Methylobacterium extorquens DM4 hypothetical protein YP_003066709.1 985674 D 661410 CDS YP_003066710.1 254559615 8191352 complement(986148..986804) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 986804 8191352 METDI1073 Methylobacterium extorquens DM4 hypothetical protein YP_003066710.1 986148 R 661410 CDS YP_003066711.1 254559616 8191353 987123..987632 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 987632 8191353 METDI1074 Methylobacterium extorquens DM4 hypothetical protein YP_003066711.1 987123 D 661410 CDS YP_003066712.1 254559617 8191354 987632..988465 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 988465 8191354 METDI1075 Methylobacterium extorquens DM4 hypothetical protein YP_003066712.1 987632 D 661410 CDS YP_003066713.1 254559618 8191355 988462..989883 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 989883 8191355 METDI1076 Methylobacterium extorquens DM4 hypothetical protein YP_003066713.1 988462 D 661410 CDS YP_003066714.1 254559619 8191356 990190..991404 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; AFG1-like ATPase 991404 8191356 METDI1078 Methylobacterium extorquens DM4 AFG1-like ATPase YP_003066714.1 990190 D 661410 CDS YP_003066715.1 254559620 8191357 complement(991401..992027) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11481431; Product type pe : putative enzyme; putative 3-methyladenine DNA glycosylase 992027 8191357 METDI1079 Methylobacterium extorquens DM4 putative 3-methyladenine DNA glycosylase YP_003066715.1 991401 R 661410 CDS YP_003066716.1 254559621 8191358 complement(992100..992777) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 1311386, 1646006, 1698262, 2169648, 2171503, 91120714, 91326034, 94051590; Product type e : enzyme; Ribonuclease H (RNase H) 992777 rnhA 8191358 rnhA Methylobacterium extorquens DM4 Ribonuclease H (RNase H) YP_003066716.1 992100 R 661410 CDS YP_003066717.1 254559622 8196003 complement(992839..993624) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 993624 8196003 METDI1081 Methylobacterium extorquens DM4 hypothetical protein YP_003066717.1 992839 R 661410 CDS YP_003066718.1 254559623 8191359 complement(993621..993872) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 993872 8191359 METDI1082 Methylobacterium extorquens DM4 hypothetical protein YP_003066718.1 993621 R 661410 CDS YP_003066719.1 254559624 8191360 994337..994645 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 994645 8191360 METDI1083 Methylobacterium extorquens DM4 hypothetical protein YP_003066719.1 994337 D 661410 CDS YP_003066720.1 254559625 8191361 994947..995909 1 NC_012988.1 catalyzes the second step in the glutathione biosynthesis pathway, where it synthesizes ATP + gamma-L-glutamyl-L-cysteine + glycine = ADP + phosphate + glutathione; glutathione synthetase 995909 gshB 8191361 gshB Methylobacterium extorquens DM4 glutathione synthetase YP_003066720.1 994947 D 661410 CDS YP_003066721.1 254559626 8195538 complement(995968..996129) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 996129 8195538 METDI1085 Methylobacterium extorquens DM4 hypothetical protein YP_003066721.1 995968 R 661410 CDS YP_003066722.1 254559627 8191362 complement(996781..998358) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type t : transporter; Na+/H+ antiporter 998358 8191362 METDI1086 Methylobacterium extorquens DM4 Na+/H+ antiporter YP_003066722.1 996781 R 661410 CDS YP_003066723.1 254559628 8191363 complement(998456..999208) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 11743193, 11743194; Product type e : enzyme; N-acetylmuramoyl-L-alanine amidase (AGR_C_3833p) 999208 8191363 METDI1087 Methylobacterium extorquens DM4 N-acetylmuramoyl-L-alanine amidase (AGR_C_3833p) YP_003066723.1 998456 R 661410 CDS YP_003066724.1 254559629 8191364 complement(999205..999930) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 11214968; Product type f : factor; DnaJ-like protein 999930 8191364 METDI1088 Methylobacterium extorquens DM4 DnaJ-like protein YP_003066724.1 999205 R 661410 CDS YP_003066725.1 254559630 8191365 complement(1000133..1000402) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 2644204; Product type lp : lipoprotein; putative OsmB-like lipoprotein 1000402 8191365 METDI1089 Methylobacterium extorquens DM4 putative OsmB-like lipoprotein YP_003066725.1 1000133 R 661410 CDS YP_003066726.1 254559631 8191366 complement(1001212..1001592) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1001592 8191366 METDI1090 Methylobacterium extorquens DM4 hypothetical protein YP_003066726.1 1001212 R 661410 CDS YP_003066727.1 254559632 8191367 complement(1001715..1001966) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1001966 8191367 METDI1091 Methylobacterium extorquens DM4 hypothetical protein YP_003066727.1 1001715 R 661410 CDS YP_003066728.1 254559633 8191368 1002429..1003451 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 22095566; Product type e : enzyme; tRNA-dihydrouridine synthase A 1003451 dusA 8191368 dusA Methylobacterium extorquens DM4 tRNA-dihydrouridine synthase A YP_003066728.1 1002429 D 661410 CDS YP_003066729.1 254559634 8195317 complement(1003491..1005635) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative diguanylate cyclase (GGDEF) /phosphodiesterase (EAL) with PAS sensor; putative membrane-associated protein precursor 1005635 8195317 METDI1093 Methylobacterium extorquens DM4 putative diguanylate cyclase (GGDEF) /phosphodiesterase (EAL) with PAS sensor; putative membrane-associated protein precursor YP_003066729.1 1003491 R 661410 CDS YP_003066730.1 254559635 8191369 complement(1005950..1006402) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative response regulator receiver (CheY-like protein) 1006402 8191369 METDI1094 Methylobacterium extorquens DM4 putative response regulator receiver (CheY-like protein) YP_003066730.1 1005950 R 661410 CDS YP_003066731.1 254559636 8191370 complement(1006464..1006931) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1006931 8191370 METDI1095 Methylobacterium extorquens DM4 hypothetical protein YP_003066731.1 1006464 R 661410 CDS YP_003066732.1 254559637 8191371 1007166..1008548 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type s : structure; putative Flagellar hook protein flgE 1008548 flgE 8191371 flgE Methylobacterium extorquens DM4 putative Flagellar hook protein flgE YP_003066732.1 1007166 D 661410 CDS YP_003066733.1 254559638 8195397 1008575..1010473 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type s : structure; putative flagellar hook-associated protein 1 FlgK 1010473 flgK 8195397 flgK Methylobacterium extorquens DM4 putative flagellar hook-associated protein 1 FlgK YP_003066733.1 1008575 D 661410 CDS YP_003066734.1 254559639 8195407 1010488..1012281 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1012281 8195407 METDI1098 Methylobacterium extorquens DM4 hypothetical protein YP_003066734.1 1010488 D 661410 CDS YP_003066735.1 254559640 8191372 complement(1012381..1013670) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1013670 8191372 METDI1099 Methylobacterium extorquens DM4 hypothetical protein YP_003066735.1 1012381 R 661410 CDS YP_003066736.1 254559641 8191373 complement(1014219..1015127) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; protein-(glutamine-N5) methyltransferase, release factor-specific 1015127 prmC 8191373 prmC Methylobacterium extorquens DM4 protein-(glutamine-N5) methyltransferase, release factor-specific YP_003066736.1 1014219 R 661410 CDS YP_003066737.1 254559642 8195900 complement(1015124..1016209) 1 NC_012988.1 recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1; this protein is similar to release factor 2; peptide chain release factor 1 1016209 prfA 8195900 prfA Methylobacterium extorquens DM4 peptide chain release factor 1 YP_003066737.1 1015124 R 661410 CDS YP_003066738.1 254559643 8195894 complement(1016404..1017063) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1017063 8195894 METDI1102 Methylobacterium extorquens DM4 hypothetical protein YP_003066738.1 1016404 R 661410 CDS YP_003066739.1 254559644 8191374 complement(1017109..1019370) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 11287431; Product type e : enzyme; phosphoenolpyruvate-protein phosphotransferase 1019370 ptsP 8191374 ptsP Methylobacterium extorquens DM4 phosphoenolpyruvate-protein phosphotransferase YP_003066739.1 1017109 R 661410 CDS YP_003066740.1 254559645 8195918 complement(1019442..1020677) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 11287431, 8100567; Product type e : enzyme; aspartate kinase 1020677 ask 8195918 ask Methylobacterium extorquens DM4 aspartate kinase YP_003066740.1 1019442 R 661410 CDS YP_003066741.1 254559646 8195109 1021045..1021782 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16926146; Product type e : enzyme; putative UbiG: ubiquinone biosynthesis O-methyltransferase 1021782 8195109 METDI1105 Methylobacterium extorquens DM4 putative UbiG: ubiquinone biosynthesis O-methyltransferase YP_003066741.1 1021045 D 661410 CDS YP_003066742.1 254559647 8191375 1021858..1022430 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1022430 8191375 METDI1106 Methylobacterium extorquens DM4 hypothetical protein YP_003066742.1 1021858 D 661410 CDS YP_003066743.1 254559648 8191376 1022570..1023550 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; Zn-binding quinone oxidoreductase 1023550 8191376 METDI1108 Methylobacterium extorquens DM4 Zn-binding quinone oxidoreductase YP_003066743.1 1022570 D 661410 CDS YP_003066744.1 254559649 8191377 complement(1023777..1024385) 1 NC_012988.1 endonuclease; resolves Holliday structures; forms a complex of RuvABC; the junction binding protein RuvA forms a hexameric ring along with the RuvB helicase and catalyzes branch migration; RuvC then interacts with RuvAB to resolve the Holliday junction by nicking DNA strands of like polarity; Holliday junction resolvase 1024385 ruvC 8191377 ruvC Methylobacterium extorquens DM4 Holliday junction resolvase YP_003066744.1 1023777 R 661410 CDS YP_003066745.1 254559650 8196097 complement(1024436..1025077) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 11298273, 15741337, 1840644, 9298646; Product type c : carrier; polyprenyl-pyrophosphate binding protein 1025077 yceI 8196097 yceI Methylobacterium extorquens DM4 polyprenyl-pyrophosphate binding protein YP_003066745.1 1024436 R 661410 CDS YP_003066746.1 254559651 8196355 1025164..1025790 1 NC_012988.1 plays an essential role in ATP-dependent branch migration of the Holliday junction; Holliday junction DNA helicase RuvA 1025790 ruvA 8196355 ruvA Methylobacterium extorquens DM4 Holliday junction DNA helicase RuvA YP_003066746.1 1025164 D 661410 CDS YP_003066747.1 254559652 8196095 complement(1025807..1026103) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1026103 8196095 METDI1112 Methylobacterium extorquens DM4 hypothetical protein YP_003066747.1 1025807 R 661410 CDS YP_003066748.1 254559653 8191378 1026181..1026561 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative response regulator receiver 1026561 8191378 METDI1113 Methylobacterium extorquens DM4 putative response regulator receiver YP_003066748.1 1026181 D 661410 CDS YP_003066749.1 254559654 8191379 1026617..1027990 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type r : regulator; response regulator (CheY-like); diguanylate cyclase (GGDEF) and response regulator receiver domains 1027990 8191379 METDI1114 Methylobacterium extorquens DM4 response regulator (CheY-like); diguanylate cyclase (GGDEF) and response regulator receiver domains YP_003066749.1 1026617 D 661410 CDS YP_003066750.1 254559655 8191380 complement(1028008..1028481) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type r : regulator; transcriptional regulator, rrf2 family 1028481 8191380 METDI1115 Methylobacterium extorquens DM4 transcriptional regulator, rrf2 family YP_003066750.1 1028008 R 661410 CDS YP_003066751.1 254559656 8191381 1028576..1029820 1 NC_012988.1 flavohemoprotein; catalyzes the formation of nitrate from nitric oxide; can also catalyze the reduction of dihydropteridine; nitric oxide dioxygenase 1029820 hmp 8191381 hmp Methylobacterium extorquens DM4 nitric oxide dioxygenase YP_003066751.1 1028576 D 661410 CDS YP_003066752.1 254559657 8195567 complement(1029848..1030012) 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 1030012 8195567 METDI1117 Methylobacterium extorquens DM4 hypothetical protein YP_003066752.1 1029848 R 661410 CDS YP_003066753.1 254559658 8191382 complement(1030055..1030399) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1030399 8191382 METDI1118 Methylobacterium extorquens DM4 hypothetical protein YP_003066753.1 1030055 R 661410 CDS YP_003066754.1 254559659 8191383 complement(1030371..1030763) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1030763 8191383 METDI1119 Methylobacterium extorquens DM4 hypothetical protein YP_003066754.1 1030371 R 661410 CDS YP_003066755.1 254559660 8191384 complement(1030852..1031832) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 10930739; Product type e : enzyme; subunit of cysteine synthase A and O-acetylserine sulfhydrolase A, PLP-dependent enzyme 1031832 cysK 8191384 cysK Methylobacterium extorquens DM4 subunit of cysteine synthase A and O-acetylserine sulfhydrolase A, PLP-dependent enzyme YP_003066755.1 1030852 R 661410 CDS YP_003066756.1 254559661 8195257 complement(1032188..1032364) 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 1032364 8195257 METDI1121 Methylobacterium extorquens DM4 hypothetical protein YP_003066756.1 1032188 R 661410 CDS YP_003066757.1 254559662 8191385 complement(1032543..1033046) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1033046 8191385 METDI1122 Methylobacterium extorquens DM4 hypothetical protein YP_003066757.1 1032543 R 661410 CDS YP_003066758.1 254559663 8191386 1033491..1033769 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1033769 8191386 METDI1123 Methylobacterium extorquens DM4 hypothetical protein YP_003066758.1 1033491 D 661410 CDS YP_003066759.1 254559664 8191387 complement(1033779..1035020) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative FAD-dependent pyridine nucleotide-disulphide oxidoreductase 1035020 8191387 METDI1124 Methylobacterium extorquens DM4 putative FAD-dependent pyridine nucleotide-disulphide oxidoreductase YP_003066759.1 1033779 R 661410 CDS YP_003066760.1 254559665 8191388 complement(1035017..1036003) 1 NC_012988.1 Evidence 1c : Function experimentally demonstrated in the studied genus; PubMedId : 12562792, 16237034; Product type r : regulator; assimilatory C1 metabolism transcriptional regulator QscR, LysR family 1036003 qscR 8191388 qscR Methylobacterium extorquens DM4 assimilatory C1 metabolism transcriptional regulator QscR, LysR family YP_003066760.1 1035017 R 661410 CDS YP_003066761.1 254559666 8195955 1036212..1037267 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 1907281; Product type e : enzyme; fructose-1,6-bisphosphatase 1037267 cbbF 8195955 cbbF Methylobacterium extorquens DM4 fructose-1,6-bisphosphatase YP_003066761.1 1036212 D 661410 CDS YP_003066762.1 254559667 8195150 1037415..1038275 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 3038847; Product type e : enzyme; phosphoribulokinase 1038275 prk 8195150 prk Methylobacterium extorquens DM4 phosphoribulokinase YP_003066762.1 1037415 D 661410 CDS YP_003066763.1 254559668 8195898 complement(1038347..1039243) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1039243 8195898 METDI1128 Methylobacterium extorquens DM4 hypothetical protein YP_003066763.1 1038347 R 661410 CDS YP_003066764.1 254559669 8191389 complement(1039422..1040168) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1040168 8191389 METDI1129 Methylobacterium extorquens DM4 hypothetical protein YP_003066764.1 1039422 R 661410 CDS YP_003066765.1 254559670 8191390 complement(1040274..1040501) 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 1040501 8191390 METDI1130 Methylobacterium extorquens DM4 hypothetical protein YP_003066765.1 1040274 R 661410 CDS YP_003066766.1 254559671 8191391 complement(1040656..1041468) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; Beta-lactamase-like 1041468 8191391 METDI1131 Methylobacterium extorquens DM4 Beta-lactamase-like YP_003066766.1 1040656 R 661410 CDS YP_003066767.1 254559672 8191392 complement(1041501..1041674) 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 1041674 8191392 METDI1132 Methylobacterium extorquens DM4 hypothetical protein YP_003066767.1 1041501 R 661410 CDS YP_003066768.1 254559673 8191393 1041900..1042214 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1042214 8191393 METDI1133 Methylobacterium extorquens DM4 hypothetical protein YP_003066768.1 1041900 D 661410 CDS YP_003066769.1 254559674 8191394 complement(1042236..1043378) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1043378 8191394 METDI1134 Methylobacterium extorquens DM4 hypothetical protein YP_003066769.1 1042236 R 661410 CDS YP_003066770.1 254559675 8191395 complement(1043378..1044754) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; putative polysaccharide export protein, PST family 1044754 8191395 METDI1135 Methylobacterium extorquens DM4 putative polysaccharide export protein, PST family YP_003066770.1 1043378 R 661410 CDS YP_003066771.1 254559676 8191396 complement(1044873..1045856) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1045856 8191396 METDI1136 Methylobacterium extorquens DM4 hypothetical protein YP_003066771.1 1044873 R 661410 CDS YP_003066772.1 254559677 8191397 complement(1045775..1046914) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 9393720; hypothetical protein 1046914 8191397 METDI1137 Methylobacterium extorquens DM4 hypothetical protein YP_003066772.1 1045775 R 661410 CDS YP_003066773.1 254559678 8191398 complement(1047103..1047864) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 9425311; Product type pe : putative enzyme; putative haloacid dehalogenase family hydrolase (C-terminal domain) 1047864 8191398 METDI1138 Methylobacterium extorquens DM4 putative haloacid dehalogenase family hydrolase (C-terminal domain) YP_003066773.1 1047103 R 661410 CDS YP_003066774.1 254559679 8191399 complement(1047858..1048541) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 10191144, 9523694, 9729441; Product type e : enzyme; D-ribulose-5-phosphate 3-epimerase 1048541 rpe 8191399 rpe Methylobacterium extorquens DM4 D-ribulose-5-phosphate 3-epimerase YP_003066774.1 1047858 R 661410 CDS YP_003066775.1 254559680 8196009 complement(1048731..1049345) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; phophinothricin N-acetyltransferase 1049345 8196009 METDI1140 Methylobacterium extorquens DM4 phophinothricin N-acetyltransferase YP_003066775.1 1048731 R 661410 CDS YP_003066776.1 254559681 8191400 complement(1049345..1051690) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type e : enzyme; ornithine decarboxylase 1051690 8191400 METDI1141 Methylobacterium extorquens DM4 ornithine decarboxylase YP_003066776.1 1049345 R 661410 CDS YP_003066777.1 254559682 8191402 complement(1052427..1052984) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 93368423; Product type e : enzyme; molybdopterin biosynthesis protein B 1052984 moaB 8191402 moaB Methylobacterium extorquens DM4 molybdopterin biosynthesis protein B YP_003066777.1 1052427 R 661410 CDS YP_003066778.1 254559683 8195703 1053147..1054454 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 10673438; Product type e : enzyme; adenylosuccinate lyase 1054454 purB 8195703 purB Methylobacterium extorquens DM4 adenylosuccinate lyase YP_003066778.1 1053147 D 661410 CDS YP_003066779.1 254559684 8195930 1054512..1055369 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 7814322; Product type e : enzyme; putative D-amino-acid transaminase (D-alanine aminotransferase) 1055369 8195930 METDI1145 Methylobacterium extorquens DM4 putative D-amino-acid transaminase (D-alanine aminotransferase) YP_003066779.1 1054512 D 661410 CDS YP_003066780.1 254559685 8191403 1055442..1055759 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1055759 8191403 METDI1146 Methylobacterium extorquens DM4 hypothetical protein YP_003066780.1 1055442 D 661410 CDS YP_003066781.1 254559686 8191404 1055893..1057239 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 3058695, 9000627; Product type e : enzyme; adenylosuccinate synthetase 1057239 purA 8191404 purA Methylobacterium extorquens DM4 adenylosuccinate synthetase YP_003066781.1 1055893 D 661410 CDS YP_003066782.1 254559687 8195929 1057281..1058759 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1058759 8195929 METDI1148 Methylobacterium extorquens DM4 hypothetical protein YP_003066782.1 1057281 D 661410 CDS YP_003066783.1 254559688 8191405 complement(1058918..1059811) 1 NC_012988.1 binds with the catalytic core of RNA polymerase to produce the holoenzyme; this sigma factor is responsible for the expression of heat shock promoters; RNA polymerase factor sigma-32 1059811 rpoH 8191405 rpoH Methylobacterium extorquens DM4 RNA polymerase factor sigma-32 YP_003066783.1 1058918 R 661410 CDS YP_003066784.1 254559689 8196048 1060257..1061186 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; transposase of ISMex17, IS110 family 1061186 8196048 METDI1150 Methylobacterium extorquens DM4 transposase of ISMex17, IS110 family YP_003066784.1 1060257 D 661410 CDS YP_003066785.1 254559690 8191406 complement(1061203..1063209) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative diguanylate cyclase/phosphodiesterase, GGDEF and EAL domains 1063209 8191406 METDI1151 Methylobacterium extorquens DM4 putative diguanylate cyclase/phosphodiesterase, GGDEF and EAL domains YP_003066785.1 1061203 R 661410 CDS YP_003066786.1 254559691 8191407 complement(1063392..1063604) 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 1063604 8191407 METDI1152 Methylobacterium extorquens DM4 hypothetical protein YP_003066786.1 1063392 R 661410 CDS YP_003066787.1 254559692 8191408 1063643..1063909 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 1063909 8191408 METDI1153 Methylobacterium extorquens DM4 hypothetical protein YP_003066787.1 1063643 D 661410 CDS YP_003066788.1 254559693 8191409 complement(1063945..1064394) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative Acetyltransferase 1064394 8191409 METDI1154 Methylobacterium extorquens DM4 putative Acetyltransferase YP_003066788.1 1063945 R 661410 CDS YP_003066789.1 254559694 8191410 1064410..1064589 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 1064589 8191410 METDI1155 Methylobacterium extorquens DM4 hypothetical protein YP_003066789.1 1064410 D 661410 CDS YP_003066790.1 254559695 8191411 complement(1064605..1065597) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; ribosomal large subunit pseudouridine synthase D (Pseudouridylate synthase) (Uracil hydrolyase) 1065597 rluD 8191411 rluD Methylobacterium extorquens DM4 ribosomal large subunit pseudouridine synthase D (Pseudouridylate synthase) (Uracil hydrolyase) YP_003066790.1 1064605 R 661410 CDS YP_003066791.1 254559696 8196000 complement(1065633..1066913) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; phage integrase 1066913 8196000 METDI1157 Methylobacterium extorquens DM4 phage integrase YP_003066791.1 1065633 R 661410 CDS YP_003066792.1 254559697 8196224 complement(1067461..1068423) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 15758242; Product type e : enzyme; phage integrase 1068423 8196224 METDI1158 Methylobacterium extorquens DM4 phage integrase YP_003066792.1 1067461 R 661410 CDS YP_003066793.1 254559698 8191413 complement(1068555..1068794) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor; putative phage-associated protein 1068794 8191413 METDI1159 Methylobacterium extorquens DM4 putative phage-associated protein YP_003066793.1 1068555 R 661410 CDS YP_003066794.1 254559699 8191414 1069974..1070282 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1070282 8191414 METDI1160 Methylobacterium extorquens DM4 hypothetical protein YP_003066794.1 1069974 D 661410 CDS YP_003066795.1 254559700 8191415 1070386..1070703 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1070703 8191415 METDI1161 Methylobacterium extorquens DM4 hypothetical protein YP_003066795.1 1070386 D 661410 CDS YP_003066796.1 254559701 8191416 complement(1070691..1072967) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 2823072; Product type prc : putative receptor; putative ferrichrome-iron receptor protein 1072967 8191416 METDI1162 Methylobacterium extorquens DM4 putative ferrichrome-iron receptor protein YP_003066796.1 1070691 R 661410 CDS YP_003066797.1 254559702 8191417 1073195..1074160 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12652904; Product type pe : putative enzyme; putative exported esterase (IroE-like) 1074160 8191417 METDI1163 Methylobacterium extorquens DM4 putative exported esterase (IroE-like) YP_003066797.1 1073195 D 661410 CDS YP_003066798.1 254559703 8191418 1075176..1075514 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1075514 8191418 METDI1164 Methylobacterium extorquens DM4 hypothetical protein YP_003066798.1 1075176 D 661410 CDS YP_003066799.1 254559704 8191419 1075908..1076549 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1076549 8191419 METDI1165 Methylobacterium extorquens DM4 hypothetical protein YP_003066799.1 1075908 D 661410 CDS YP_003066800.1 254559705 8191420 1076546..1079182 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative ATP-hydrolyzing enzyme 1079182 8191420 METDI1166 Methylobacterium extorquens DM4 putative ATP-hydrolyzing enzyme YP_003066800.1 1076546 D 661410 CDS YP_003066801.1 254559706 8191421 1079765..1081510 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative resolvase/recombinase 1081510 8191421 METDI1168 Methylobacterium extorquens DM4 putative resolvase/recombinase YP_003066801.1 1079765 D 661410 CDS YP_003066802.1 254559707 8191422 1081938..1084061 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative resolvase/recombinase 1084061 8191422 METDI1170 Methylobacterium extorquens DM4 putative resolvase/recombinase YP_003066802.1 1081938 D 661410 CDS YP_003066803.1 254559708 8191423 1084049..1084249 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 1084249 8191423 METDI1171 Methylobacterium extorquens DM4 hypothetical protein YP_003066803.1 1084049 D 661410 CDS YP_003066804.1 254559709 8191424 complement(1084567..1084764) 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 1084764 8191424 METDI1172 Methylobacterium extorquens DM4 hypothetical protein YP_003066804.1 1084567 R 661410 CDS YP_003066805.1 254559710 8191425 complement(1084658..1085380) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1085380 8191425 METDI1173 Methylobacterium extorquens DM4 hypothetical protein YP_003066805.1 1084658 R 661410 CDS YP_003066806.1 254559711 8191426 complement(1085561..1086064) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1086064 8191426 METDI1174 Methylobacterium extorquens DM4 hypothetical protein YP_003066806.1 1085561 R 661410 CDS YP_003066807.1 254559712 8191427 1086246..1086458 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcriptional repressor 1086458 8191427 METDI1175 Methylobacterium extorquens DM4 putative transcriptional repressor YP_003066807.1 1086246 D 661410 CDS YP_003066808.1 254559713 8191428 1086681..1087610 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 16517654; Product type e : enzyme; transposase of ISMdi4, IS481 family 1087610 8191428 METDI1176 Methylobacterium extorquens DM4 transposase of ISMdi4, IS481 family YP_003066808.1 1086681 D 661410 CDS YP_003066809.1 254559714 8191431 1089097..1089390 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 1089390 8191431 METDI1179 Methylobacterium extorquens DM4 hypothetical protein YP_003066809.1 1089097 D 661410 CDS YP_003066810.1 254559715 8191432 1089412..1090290 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1090290 8191432 METDI1180 Methylobacterium extorquens DM4 hypothetical protein YP_003066810.1 1089412 D 661410 CDS YP_003066811.1 254559716 8191433 1090287..1092338 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative ATP-hydrolyzing enzyme 1092338 8191433 METDI1181 Methylobacterium extorquens DM4 putative ATP-hydrolyzing enzyme YP_003066811.1 1090287 D 661410 CDS YP_003066812.1 254559717 8191434 1092476..1092937 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1092937 8191434 METDI1182 Methylobacterium extorquens DM4 hypothetical protein YP_003066812.1 1092476 D 661410 CDS YP_003066813.1 254559718 8191435 1093400..1094062 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1094062 8191435 METDI1183 Methylobacterium extorquens DM4 hypothetical protein YP_003066813.1 1093400 D 661410 CDS YP_003066814.1 254559719 8191436 complement(1094076..1094345) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1094345 8191436 METDI1184 Methylobacterium extorquens DM4 hypothetical protein YP_003066814.1 1094076 R 661410 CDS YP_003066815.1 254559720 8191437 complement(1094694..1095083) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1095083 8191437 METDI1185 Methylobacterium extorquens DM4 hypothetical protein YP_003066815.1 1094694 R 661410 CDS YP_003066816.1 254559721 8191438 complement(1095320..1095445) 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 1095445 8191438 METDI1186 Methylobacterium extorquens DM4 hypothetical protein YP_003066816.1 1095320 R 661410 CDS YP_003066817.1 254559722 8191439 complement(1095480..1096160) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type f : factor; RNA polymerase sigma factor 1096160 8191439 METDI1187 Methylobacterium extorquens DM4 RNA polymerase sigma factor YP_003066817.1 1095480 R 661410 CDS YP_003066818.1 254559723 8191440 complement(1096639..1098228) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1098228 8191440 METDI1188 Methylobacterium extorquens DM4 hypothetical protein YP_003066818.1 1096639 R 661410 CDS YP_003066819.1 254559724 8191441 complement(1098672..1099154) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1099154 8191441 METDI1190 Methylobacterium extorquens DM4 hypothetical protein YP_003066819.1 1098672 R 661410 CDS YP_003066820.1 254559725 8191442 1099238..1099339 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 1099339 8191442 METDI1191 Methylobacterium extorquens DM4 hypothetical protein YP_003066820.1 1099238 D 661410 CDS YP_003066821.1 254559726 8191445 complement(1101319..1102368) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type t : transporter; carbohydrate-selective porin 1102368 8191445 METDI1195 Methylobacterium extorquens DM4 carbohydrate-selective porin YP_003066821.1 1101319 R 661410 CDS YP_003066822.1 254559727 8191446 1103420..1103863 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1103863 8191446 METDI1196 Methylobacterium extorquens DM4 hypothetical protein YP_003066822.1 1103420 D 661410 CDS YP_003066823.1 254559728 8191447 1103716..1103997 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 1103997 8191447 METDI1197 Methylobacterium extorquens DM4 hypothetical protein YP_003066823.1 1103716 D 661410 CDS YP_003066824.1 254559729 8191448 1104086..1104370 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1104370 8191448 METDI1198 Methylobacterium extorquens DM4 hypothetical protein YP_003066824.1 1104086 D 661410 CDS YP_003066825.1 254559730 8191449 1105280..1106014 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding response regulator in two-component regulatory system with ArcB or CpxA (putative arcA=cpxC, dye, fexA, msp) 1106014 8191449 METDI1199 Methylobacterium extorquens DM4 putative DNA-binding response regulator in two-component regulatory system with ArcB or CpxA (putative arcA=cpxC, dye, fexA, msp) YP_003066825.1 1105280 D 661410 CDS YP_003066826.1 254559731 8191450 1106011..1107345 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type prc : putative receptor; putative integral membrane sensor signal transduction histidine kinase 1107345 8191450 METDI1200 Methylobacterium extorquens DM4 putative integral membrane sensor signal transduction histidine kinase YP_003066826.1 1106011 D 661410 CDS YP_003066827.1 254559732 8191451 1107575..1107847 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 1107847 8191451 METDI1201 Methylobacterium extorquens DM4 hypothetical protein YP_003066827.1 1107575 D 661410 CDS YP_003066828.1 254559733 8191452 1107835..1108188 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1108188 8191452 METDI1202 Methylobacterium extorquens DM4 hypothetical protein YP_003066828.1 1107835 D 661410 CDS YP_003066829.1 254559734 8191453 complement(1108257..1108490) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1108490 8191453 METDI1203 Methylobacterium extorquens DM4 hypothetical protein YP_003066829.1 1108257 R 661410 CDS YP_003066830.1 254559735 8191454 1108260..1108451 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 1108451 8191454 METDI1204 Methylobacterium extorquens DM4 hypothetical protein YP_003066830.1 1108260 D 661410 CDS YP_003066831.1 254559736 8191455 1108796..1109167 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1109167 8191455 METDI1205 Methylobacterium extorquens DM4 hypothetical protein YP_003066831.1 1108796 D 661410 CDS YP_003066832.1 254559737 8191456 1109292..1110656 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10570969, 16926146; Product type pt : putative transporter; putative secretion protein, putative RND family efflux protein 1110656 8191456 METDI1206 Methylobacterium extorquens DM4 putative secretion protein, putative RND family efflux protein YP_003066832.1 1109292 D 661410 CDS YP_003066833.1 254559738 8191457 1110668..1113916 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 7766206; Product type t : transporter; Cobalt-zinc-cadmium resistance protein czcA (Cation efflux system protein czcA) 1113916 czcA 8191457 czcA Methylobacterium extorquens DM4 Cobalt-zinc-cadmium resistance protein czcA (Cation efflux system protein czcA) YP_003066833.1 1110668 D 661410 CDS YP_003066834.1 254559739 8195265 1113922..1114476 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; PubMedId : 11872709; hypothetical protein 1114476 8195265 METDI1208 Methylobacterium extorquens DM4 hypothetical protein YP_003066834.1 1113922 D 661410 CDS YP_003066835.1 254559740 8191458 1114522..1115439 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 2678100, 9044283; Product type t : transporter; Cobalt-zinc-cadmium resistance protein czcD (Cation efflux system protein czcD) 1115439 czcD 8191458 czcD Methylobacterium extorquens DM4 Cobalt-zinc-cadmium resistance protein czcD (Cation efflux system protein czcD) YP_003066835.1 1114522 D 661410 CDS YP_003066836.1 254559741 8195269 1115452..1115622 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1115622 8195269 METDI1210 Methylobacterium extorquens DM4 hypothetical protein YP_003066836.1 1115452 D 661410 CDS YP_003066837.1 254559742 8191459 1115945..1116199 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 1116199 8191459 METDI1211 Methylobacterium extorquens DM4 hypothetical protein YP_003066837.1 1115945 D 661410 CDS YP_003066838.1 254559743 8191460 1116438..1116578 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 1116578 8191460 METDI1212 Methylobacterium extorquens DM4 hypothetical protein YP_003066838.1 1116438 D 661410 CDS YP_003066839.1 254559744 8191461 complement(1116575..1118119) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1118119 8191461 METDI1213 Methylobacterium extorquens DM4 hypothetical protein YP_003066839.1 1116575 R 661410 CDS YP_003066840.1 254559745 8191462 complement(1118322..1119062) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1119062 8191462 METDI1214 Methylobacterium extorquens DM4 hypothetical protein YP_003066840.1 1118322 R 661410 CDS YP_003066841.1 254559746 8191463 1119250..1119516 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 1119516 8191463 METDI1215 Methylobacterium extorquens DM4 hypothetical protein YP_003066841.1 1119250 D 661410 CDS YP_003066842.1 254559747 8191464 complement(1119632..1119844) 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 1119844 8191464 METDI1216 Methylobacterium extorquens DM4 hypothetical protein YP_003066842.1 1119632 R 661410 CDS YP_003066843.1 254559748 8191466 complement(1120205..1120474) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1120474 8191466 METDI1218 Methylobacterium extorquens DM4 hypothetical protein YP_003066843.1 1120205 R 661410 CDS YP_003066844.1 254559749 8191468 complement(1120734..1121024) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1121024 8191468 METDI1220 Methylobacterium extorquens DM4 hypothetical protein YP_003066844.1 1120734 R 661410 CDS YP_003066845.1 254559750 8191469 complement(1121043..1121198) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1121198 8191469 METDI1221 Methylobacterium extorquens DM4 hypothetical protein YP_003066845.1 1121043 R 661410 CDS YP_003066846.1 254559751 8191470 complement(1121255..1121677) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1121677 8191470 METDI1222 Methylobacterium extorquens DM4 hypothetical protein YP_003066846.1 1121255 R 661410 CDS YP_003066847.1 254559752 8191471 complement(1121808..1123142) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 17186148, 17293508; Product type t : transporter; putative NcrA-like major facilitator superfamily permease 1123142 8191471 METDI1223 Methylobacterium extorquens DM4 putative NcrA-like major facilitator superfamily permease YP_003066847.1 1121808 R 661410 CDS YP_003066848.1 254559753 8191472 complement(1123150..1123419) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 17186148, 17293508; Product type pf : putative factor; putative NcrB-like regulator, DUF156 1123419 8191472 METDI1224 Methylobacterium extorquens DM4 putative NcrB-like regulator, DUF156 YP_003066848.1 1123150 R 661410 CDS YP_003066849.1 254559754 8191473 1123648..1123986 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor; putative system killer suppression protein 1123986 8191473 METDI1225 Methylobacterium extorquens DM4 putative system killer suppression protein YP_003066849.1 1123648 D 661410 CDS YP_003066850.1 254559755 8191474 1124004..1125098 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8645296; Product type pr : putative regulator; putative plasmid maintenance system antidote protein, HTH DNA-binding domain 1125098 8191474 METDI1226 Methylobacterium extorquens DM4 putative plasmid maintenance system antidote protein, HTH DNA-binding domain YP_003066850.1 1124004 D 661410 CDS YP_003066851.1 254559756 8191475 1125237..1125527 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1125527 8191475 METDI1227 Methylobacterium extorquens DM4 hypothetical protein YP_003066851.1 1125237 D 661410 CDS YP_003066852.1 254559757 8191476 complement(1125530..1126027) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1126027 8191476 METDI1228 Methylobacterium extorquens DM4 hypothetical protein YP_003066852.1 1125530 R 661410 CDS YP_003066853.1 254559758 8191477 complement(1125987..1126418) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1126418 8191477 METDI1229 Methylobacterium extorquens DM4 hypothetical protein YP_003066853.1 1125987 R 661410 CDS YP_003066854.1 254559759 8191478 complement(1126587..1126952) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1126952 8191478 METDI1230 Methylobacterium extorquens DM4 hypothetical protein YP_003066854.1 1126587 R 661410 CDS YP_003066855.1 254559760 8191479 complement(1126986..1130213) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type t : transporter; Heavy metal efflux pump CzcA (precursor) 1130213 8191479 METDI1231 Methylobacterium extorquens DM4 Heavy metal efflux pump CzcA (precursor) YP_003066855.1 1126986 R 661410 CDS YP_003066856.1 254559761 8191480 complement(1130227..1131957) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1131957 8191480 METDI1232 Methylobacterium extorquens DM4 hypothetical protein YP_003066856.1 1130227 R 661410 CDS YP_003066857.1 254559762 8191481 complement(1132040..1132423) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1132423 8191481 METDI1233 Methylobacterium extorquens DM4 hypothetical protein YP_003066857.1 1132040 R 661410 CDS YP_003066858.1 254559763 8191482 complement(1132743..1133009) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1133009 8191482 METDI1235 Methylobacterium extorquens DM4 hypothetical protein YP_003066858.1 1132743 R 661410 CDS YP_003066859.1 254559764 8191484 1132746..1132991 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 1132991 8191484 METDI1234 Methylobacterium extorquens DM4 hypothetical protein YP_003066859.1 1132746 D 661410 CDS YP_003066860.1 254559765 8191483 1133181..1133396 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 1133396 8191483 METDI1236 Methylobacterium extorquens DM4 hypothetical protein YP_003066860.1 1133181 D 661410 CDS YP_003066861.1 254559766 8191488 complement(1134661..1136205) 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 1136205 8191488 METDI1241 Methylobacterium extorquens DM4 hypothetical protein YP_003066861.1 1134661 R 661410 CDS YP_003066862.1 254559767 8191489 complement(1136269..1136595) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1136595 8191489 METDI1242 Methylobacterium extorquens DM4 hypothetical protein YP_003066862.1 1136269 R 661410 CDS YP_003066863.1 254559768 8191490 complement(1136674..1136772) 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 1136772 8191490 METDI1243 Methylobacterium extorquens DM4 hypothetical protein YP_003066863.1 1136674 R 661410 CDS YP_003066864.1 254559769 8191491 complement(1137027..1137746) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier; putative cytochrome c biogenesis protein precursor 1137746 8191491 METDI1244 Methylobacterium extorquens DM4 putative cytochrome c biogenesis protein precursor YP_003066864.1 1137027 R 661410 CDS YP_003066865.1 254559770 8191492 complement(1137753..1138145) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; Thioredoxin-related 1138145 8191492 METDI1245 Methylobacterium extorquens DM4 Thioredoxin-related YP_003066865.1 1137753 R 661410 CDS YP_003066866.1 254559771 8191493 complement(1138174..1138974) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1138974 8191493 METDI1246 Methylobacterium extorquens DM4 hypothetical protein YP_003066866.1 1138174 R 661410 CDS YP_003066867.1 254559772 8191494 1139112..1139348 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 1139348 8191494 METDI1247 Methylobacterium extorquens DM4 hypothetical protein YP_003066867.1 1139112 D 661410 CDS YP_003066868.1 254559773 8191495 1139548..1139838 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1139838 8191495 METDI1248 Methylobacterium extorquens DM4 hypothetical protein YP_003066868.1 1139548 D 661410 CDS YP_003066869.1 254559774 8191496 1139835..1140389 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1140389 8191496 METDI1249 Methylobacterium extorquens DM4 hypothetical protein YP_003066869.1 1139835 D 661410 CDS YP_003066870.1 254559775 8191497 complement(1140638..1140814) 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 1140814 8191497 METDI1250 Methylobacterium extorquens DM4 hypothetical protein YP_003066870.1 1140638 R 661410 CDS YP_003066871.1 254559776 8191498 complement(1141760..1142683) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type e : enzyme; transposase of ISMex31, IS110 family 1142683 8191498 METDI1251 Methylobacterium extorquens DM4 transposase of ISMex31, IS110 family YP_003066871.1 1141760 R 661410 CDS YP_003066872.1 254559777 8191502 complement(1144811..1145026) 1 NC_012988.1 Evidence 6 : Doubtful CDS; Product type e : enzyme; hypothetical protein 1145026 8191502 METDI1255 Methylobacterium extorquens DM4 hypothetical protein YP_003066872.1 1144811 R 661410 CDS YP_003066873.1 254559778 8191503 complement(1144954..1145121) 1 NC_012988.1 Evidence 6 : Doubtful CDS; Product type e : enzyme; hypothetical protein 1145121 8191503 METDI1256 Methylobacterium extorquens DM4 hypothetical protein YP_003066873.1 1144954 R 661410 CDS YP_003066874.1 254559779 8191504 1145247..1145693 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1145693 8191504 METDI1257 Methylobacterium extorquens DM4 hypothetical protein YP_003066874.1 1145247 D 661410 CDS YP_003066875.1 254559780 8191506 complement(1146046..1147119) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1147119 8191506 METDI1259 Methylobacterium extorquens DM4 hypothetical protein YP_003066875.1 1146046 R 661410 CDS YP_003066876.1 254559781 8191507 complement(1147208..1147729) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative prolipoprotein signal peptidase (SPase II) 1147729 lspA 8191507 lspA Methylobacterium extorquens DM4 putative prolipoprotein signal peptidase (SPase II) YP_003066876.1 1147208 R 661410 CDS YP_003066877.1 254559782 8195652 complement(1147726..1149921) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 10660539, 12746428, 21305696, 9364914, 9405611, 98070750, 99428388; Product type t : transporter; zinc, cadmium, cobalt and lead efflux system 1149921 zntA 8195652 zntA Methylobacterium extorquens DM4 zinc, cadmium, cobalt and lead efflux system YP_003066877.1 1147726 R 661410 CDS YP_003066878.1 254559783 8196379 1150022..1150423 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 11936079, 12213931; Product type pr : putative regulator; heavy metal resistance transcriptional regulator HmrR, MerR family 1150423 hmrR 8196379 hmrR Methylobacterium extorquens DM4 heavy metal resistance transcriptional regulator HmrR, MerR family YP_003066878.1 1150022 D 661410 CDS YP_003066879.1 254559784 8195569 complement(1150656..1150904) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1150904 8195569 METDI1263 Methylobacterium extorquens DM4 hypothetical protein YP_003066879.1 1150656 R 661410 CDS YP_003066880.1 254559785 8191508 complement(1151100..1153520) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 11936079, 9930866; Product type t : transporter; cation transporting P-type ATPase 1153520 actP 8191508 actP Methylobacterium extorquens DM4 cation transporting P-type ATPase YP_003066880.1 1151100 R 661410 CDS YP_003066881.1 254559786 8195059 complement(1153588..1154070) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1154070 8195059 METDI1265 Methylobacterium extorquens DM4 hypothetical protein YP_003066881.1 1153588 R 661410 CDS YP_003066882.1 254559787 8191509 complement(1154125..1154457) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1154457 8191509 METDI1267 Methylobacterium extorquens DM4 hypothetical protein YP_003066882.1 1154125 R 661410 CDS YP_003066883.1 254559788 8191510 complement(1154637..1155035) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1155035 8191510 METDI1268 Methylobacterium extorquens DM4 hypothetical protein YP_003066883.1 1154637 R 661410 CDS YP_003066884.1 254559789 8191511 complement(1155062..1155427) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1155427 8191511 METDI1269 Methylobacterium extorquens DM4 hypothetical protein YP_003066884.1 1155062 R 661410 CDS YP_003066885.1 254559790 8191512 complement(1155447..1158596) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type t : transporter; Heavy metal efflux pump CzcA (precursor) 1158596 8191512 METDI1270 Methylobacterium extorquens DM4 Heavy metal efflux pump CzcA (precursor) YP_003066885.1 1155447 R 661410 CDS YP_003066886.1 254559791 8191513 complement(1158610..1160349) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1160349 8191513 METDI1271 Methylobacterium extorquens DM4 hypothetical protein YP_003066886.1 1158610 R 661410 CDS YP_003066887.1 254559792 8191514 complement(1160430..1160903) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1160903 8191514 METDI1272 Methylobacterium extorquens DM4 hypothetical protein YP_003066887.1 1160430 R 661410 CDS YP_003066888.1 254559793 8191515 complement(1160435..1160797) 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 1160797 8191515 METDI1273 Methylobacterium extorquens DM4 hypothetical protein YP_003066888.1 1160435 R 661410 CDS YP_003066889.1 254559794 8191516 complement(1160995..1161207) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 12213931; Product type pf : putative factor; CopP metal-binding protein, putative exported protein 1161207 copP 8191516 copP Methylobacterium extorquens DM4 CopP metal-binding protein, putative exported protein YP_003066889.1 1160995 R 661410 CDS YP_003066890.1 254559795 8195203 1161654..1162328 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1162328 8195203 METDI1275 Methylobacterium extorquens DM4 hypothetical protein YP_003066890.1 1161654 D 661410 CDS YP_003066891.1 254559796 8191517 complement(1162342..1162818) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1162818 8191517 METDI1276 Methylobacterium extorquens DM4 hypothetical protein YP_003066891.1 1162342 R 661410 CDS YP_003066892.1 254559797 8191518 complement(1162838..1166011) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 11399769, 12813074, 1711024, 20461235, 21125583, 21178899, 21450803, 79844; Product type t : transporter; outer membrane copper (silver) and drug transport protein (RND family) 1166011 cusA 8191518 cusA Methylobacterium extorquens DM4 outer membrane copper (silver) and drug transport protein (RND family) YP_003066892.1 1162838 R 661410 CDS YP_003066893.1 254559798 8195229 complement(1166008..1167525) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative secretion protein precursor, putative RND family efflux protein 1167525 8195229 METDI1278 Methylobacterium extorquens DM4 putative secretion protein precursor, putative RND family efflux protein YP_003066893.1 1166008 R 661410 CDS YP_003066894.1 254559799 8191519 complement(1167522..1167926) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1167926 8191519 METDI1279 Methylobacterium extorquens DM4 hypothetical protein YP_003066894.1 1167522 R 661410 CDS YP_003066895.1 254559800 8191520 complement(1168008..1168406) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1168406 8191520 METDI1280 Methylobacterium extorquens DM4 hypothetical protein YP_003066895.1 1168008 R 661410 CDS YP_003066896.1 254559801 8191521 1169202..1169396 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 1169396 8191521 METDI1281 Methylobacterium extorquens DM4 hypothetical protein YP_003066896.1 1169202 D 661410 CDS YP_003066897.1 254559802 8191522 complement(1169453..1169626) 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 1169626 8191522 METDI1282 Methylobacterium extorquens DM4 hypothetical protein YP_003066897.1 1169453 R 661410 CDS YP_003066898.1 254559803 8191523 1170165..1170491 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1170491 8191523 METDI1283 Methylobacterium extorquens DM4 hypothetical protein YP_003066898.1 1170165 D 661410 CDS YP_003066899.1 254559804 8191524 1170720..1171064 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1171064 8191524 METDI1284 Methylobacterium extorquens DM4 hypothetical protein YP_003066899.1 1170720 D 661410 CDS YP_003066900.1 254559805 8191525 complement(1171061..1171507) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1171507 8191525 METDI1285 Methylobacterium extorquens DM4 hypothetical protein YP_003066900.1 1171061 R 661410 CDS YP_003066901.1 254559806 8191527 complement(1173291..1173812) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1173812 8191527 METDI1287 Methylobacterium extorquens DM4 hypothetical protein YP_003066901.1 1173291 R 661410 CDS YP_003066902.1 254559807 8195943 complement(1175709..1175879) 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 1175879 8195943 METDI1290 Methylobacterium extorquens DM4 hypothetical protein YP_003066902.1 1175709 R 661410 CDS YP_003066903.1 254559808 8191529 1176037..1179213 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative Alkaline phosphatase; Hemolysin-type calcium-binding domain 1179213 8191529 METDI1291 Methylobacterium extorquens DM4 putative Alkaline phosphatase; Hemolysin-type calcium-binding domain YP_003066903.1 1176037 D 661410 CDS YP_003066904.1 254559809 8191530 1179442..1179723 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; transposase of ISMdi3, IS3 family (ORF 1) 1179723 8191530 METDI1292 Methylobacterium extorquens DM4 transposase of ISMdi3, IS3 family (ORF 1) YP_003066904.1 1179442 D 661410 CDS YP_003066905.1 254559810 8191531 1179831..1180583 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; transposase of ISMdi3, IS3 family (ORF 2) 1180583 8191531 METDI1293 Methylobacterium extorquens DM4 transposase of ISMdi3, IS3 family (ORF 2) YP_003066905.1 1179831 D 661410 CDS YP_003066906.1 254559811 8191532 1180769..1181698 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; transposase of ISMex17, IS110 family 1181698 8191532 METDI1294 Methylobacterium extorquens DM4 transposase of ISMex17, IS110 family YP_003066906.1 1180769 D 661410 CDS YP_003066907.1 254559812 8191533 1182098..1182352 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1182352 8191533 METDI1295 Methylobacterium extorquens DM4 hypothetical protein YP_003066907.1 1182098 D 661410 CDS YP_003066908.1 254559813 8191534 complement(1182359..1182616) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1182616 8191534 METDI1296 Methylobacterium extorquens DM4 hypothetical protein YP_003066908.1 1182359 R 661410 CDS YP_003066909.1 254559814 8191535 1182922..1183113 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1183113 8191535 METDI1297 Methylobacterium extorquens DM4 hypothetical protein YP_003066909.1 1182922 D 661410 CDS YP_003066910.1 254559815 8195032 1183589..1185808 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type rc : receptor; TonB-dependent siderophore receptor 1185808 8195032 METDI1298 Methylobacterium extorquens DM4 TonB-dependent siderophore receptor YP_003066910.1 1183589 D 661410 CDS YP_003066911.1 254559816 8191537 1185812..1187251 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1187251 8191537 METDI1299 Methylobacterium extorquens DM4 hypothetical protein YP_003066911.1 1185812 D 661410 CDS YP_003066912.1 254559817 8191538 1187646..1187780 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 1187780 8191538 METDI1300 Methylobacterium extorquens DM4 hypothetical protein YP_003066912.1 1187646 D 661410 CDS YP_003066913.1 254559818 8191539 complement(1187833..1188216) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1188216 8191539 METDI1301 Methylobacterium extorquens DM4 hypothetical protein YP_003066913.1 1187833 R 661410 CDS YP_003066914.1 254559819 8191540 complement(1188850..1189830) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative ArsB-like efflux protein 1189830 8191540 METDI1302 Methylobacterium extorquens DM4 putative ArsB-like efflux protein YP_003066914.1 1188850 R 661410 CDS YP_003066915.1 254559820 8191541 complement(1189827..1190213) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 10788346, 12829264, 9537360; Product type r : regulator; transcriptional regulator, ArsR family 1190213 arsR 8191541 arsR Methylobacterium extorquens DM4 transcriptional regulator, ArsR family YP_003066915.1 1189827 R 661410 CDS YP_003066916.1 254559821 8195104 1190645..1192351 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type prc : putative receptor; putative methyl-accepting chemotaxis sensory transducer precursor 1192351 8195104 METDI1304 Methylobacterium extorquens DM4 putative methyl-accepting chemotaxis sensory transducer precursor YP_003066916.1 1190645 D 661410 CDS YP_003066917.1 254559822 8191542 1192948..1193085 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1193085 8191542 METDI1305 Methylobacterium extorquens DM4 hypothetical protein YP_003066917.1 1192948 D 661410 CDS YP_003066918.1 254559823 8191543 complement(1193133..1193879) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 10788346; Product type e : enzyme; NADPH-dependent FMN reductase 1193879 arsH 8191543 arsH Methylobacterium extorquens DM4 NADPH-dependent FMN reductase YP_003066918.1 1193133 R 661410 CDS YP_003066919.1 254559824 8195101 1193930..1194289 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 10788346, 12829264, 9537360; Product type r : regulator; transcriptional regulator, ArsR family 1194289 arsR 8195101 arsR Methylobacterium extorquens DM4 transcriptional regulator, ArsR family YP_003066919.1 1193930 D 661410 CDS YP_003066920.1 254559825 8195105 1194282..1194809 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 11573087, 16905151; Product type e : enzyme; arsenate reductase / phosphotyrosine protein phosphatase 1194809 arsC 8195105 arsC Methylobacterium extorquens DM4 arsenate reductase / phosphotyrosine protein phosphatase YP_003066920.1 1194282 D 661410 CDS YP_003066921.1 254559826 8195097 1194809..1195234 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 16905151, 17432936; Product type e : enzyme; arsenate reductase (glutaredoxin family) 1195234 arsC 8195097 arsC Methylobacterium extorquens DM4 arsenate reductase (glutaredoxin family) YP_003066921.1 1194809 D 661410 CDS YP_003066922.1 254559827 8191544 1195990..1196271 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; transposase of ISMdi3, IS3 family (ORF 1) 1196271 8191544 METDI1311 Methylobacterium extorquens DM4 transposase of ISMdi3, IS3 family (ORF 1) YP_003066922.1 1195990 D 661410 CDS YP_003066923.1 254559828 8191545 1196379..1197131 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; transposase of ISMdi3, IS3 family (ORF 2) 1197131 8191545 METDI1312 Methylobacterium extorquens DM4 transposase of ISMdi3, IS3 family (ORF 2) YP_003066923.1 1196379 D 661410 CDS YP_003066924.1 254559829 8191546 1197317..1198246 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; transposase of ISMex17, IS110 family 1198246 8191546 METDI1313 Methylobacterium extorquens DM4 transposase of ISMex17, IS110 family YP_003066924.1 1197317 D 661410 CDS YP_003066925.1 254559830 8191547 1198333..1198572 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1198572 8191547 METDI1314 Methylobacterium extorquens DM4 hypothetical protein YP_003066925.1 1198333 D 661410 CDS YP_003066926.1 254559831 8191548 complement(1198729..1199019) 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 1199019 8191548 METDI1315 Methylobacterium extorquens DM4 hypothetical protein YP_003066926.1 1198729 R 661410 CDS YP_003066927.1 254559832 8191549 complement(1199111..1199380) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1199380 8191549 METDI1316 Methylobacterium extorquens DM4 hypothetical protein YP_003066927.1 1199111 R 661410 CDS YP_003066928.1 254559833 8191550 complement(1199730..1200155) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1200155 8191550 METDI1317 Methylobacterium extorquens DM4 hypothetical protein YP_003066928.1 1199730 R 661410 CDS YP_003066929.1 254559834 8191551 complement(1200356..1200622) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1200622 8191551 METDI1318 Methylobacterium extorquens DM4 hypothetical protein YP_003066929.1 1200356 R 661410 CDS YP_003066930.1 254559835 8191552 1201006..1201443 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1201443 8191552 METDI1319 Methylobacterium extorquens DM4 hypothetical protein YP_003066930.1 1201006 D 661410 CDS YP_003066931.1 254559836 8191553 1201530..1203281 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1203281 8191553 METDI1320 Methylobacterium extorquens DM4 hypothetical protein YP_003066931.1 1201530 D 661410 CDS YP_003066932.1 254559837 8191554 1203294..1206437 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type t : transporter; Heavy metal efflux pump CzcA (precursor) 1206437 czcA 8191554 czcA Methylobacterium extorquens DM4 Heavy metal efflux pump CzcA (precursor) YP_003066932.1 1203294 D 661410 CDS YP_003066933.1 254559838 8195266 1206471..1206836 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1206836 8195266 METDI1322 Methylobacterium extorquens DM4 hypothetical protein YP_003066933.1 1206471 D 661410 CDS YP_003066934.1 254559839 8191555 1206859..1207293 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 12670971; hypothetical protein 1207293 8191555 METDI1323 Methylobacterium extorquens DM4 hypothetical protein YP_003066934.1 1206859 D 661410 CDS YP_003066935.1 254559840 8191556 1207485..1207817 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1207817 8191556 METDI1324 Methylobacterium extorquens DM4 hypothetical protein YP_003066935.1 1207485 D 661410 CDS YP_003066936.1 254559841 8191557 1207841..1208074 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1208074 8191557 METDI1325 Methylobacterium extorquens DM4 hypothetical protein YP_003066936.1 1207841 D 661410 CDS YP_003066937.1 254559842 8191558 1208240..1210669 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 11238972, 16151171; Product type t : transporter; cation transporting P-type ATPase 1210669 8191558 METDI1326 Methylobacterium extorquens DM4 cation transporting P-type ATPase YP_003066937.1 1208240 D 661410 CDS YP_003066938.1 254559843 8191559 1210980..1211456 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1211456 8191559 METDI1327 Methylobacterium extorquens DM4 hypothetical protein YP_003066938.1 1210980 D 661410 CDS YP_003066939.1 254559844 8191560 complement(1211520..1211711) 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 1211711 8191560 METDI1328 Methylobacterium extorquens DM4 hypothetical protein YP_003066939.1 1211520 R 661410 CDS YP_003066940.1 254559845 8191561 1211791..1212006 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 1212006 8191561 METDI1329 Methylobacterium extorquens DM4 hypothetical protein YP_003066940.1 1211791 D 661410 CDS YP_003066941.1 254559846 8191566 1213441..1215444 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type prc : putative receptor; putative outer membrane receptor for iron transport 1215444 8191566 METDI1335 Methylobacterium extorquens DM4 putative outer membrane receptor for iron transport YP_003066941.1 1213441 D 661410 CDS YP_003066942.1 254559847 8191567 complement(1215346..1215594) 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 1215594 8191567 METDI1336 Methylobacterium extorquens DM4 hypothetical protein YP_003066942.1 1215346 R 661410 CDS YP_003066943.1 254559848 8191568 complement(1216898..1217200) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1217200 8191568 METDI1338 Methylobacterium extorquens DM4 hypothetical protein YP_003066943.1 1216898 R 661410 CDS YP_003066944.1 254559849 8191569 complement(1217834..1218121) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1218121 8191569 METDI1339 Methylobacterium extorquens DM4 hypothetical protein YP_003066944.1 1217834 R 661410 CDS YP_003066945.1 254559850 8191570 1218157..1219449 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1219449 8191570 METDI1340 Methylobacterium extorquens DM4 hypothetical protein YP_003066945.1 1218157 D 661410 CDS YP_003066946.1 254559851 8191571 1219900..1221357 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1221357 8191571 METDI1341 Methylobacterium extorquens DM4 hypothetical protein YP_003066946.1 1219900 D 661410 CDS YP_003066947.1 254559852 8191572 complement(1221392..1221607) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1221607 8191572 METDI1342 Methylobacterium extorquens DM4 hypothetical protein YP_003066947.1 1221392 R 661410 CDS YP_003066948.1 254559853 8191573 complement(1221658..1222542) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1222542 8191573 METDI1343 Methylobacterium extorquens DM4 hypothetical protein YP_003066948.1 1221658 R 661410 CDS YP_003066949.1 254559854 8191575 complement(1223571..1224323) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1224323 8191575 METDI1345 Methylobacterium extorquens DM4 hypothetical protein YP_003066949.1 1223571 R 661410 CDS YP_003066950.1 254559855 8191576 complement(1224397..1224747) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1224747 8191576 METDI1346 Methylobacterium extorquens DM4 hypothetical protein YP_003066950.1 1224397 R 661410 CDS YP_003066951.1 254559856 8191577 complement(1224462..1224518) 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 1224518 8191577 METDI1347 Methylobacterium extorquens DM4 hypothetical protein YP_003066951.1 1224462 R 661410 CDS YP_003066952.1 254559857 8191578 complement(1224816..1225250) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1225250 8191578 METDI1348 Methylobacterium extorquens DM4 hypothetical protein YP_003066952.1 1224816 R 661410 CDS YP_003066953.1 254559858 8191579 complement(1225930..1226400) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1226400 8191579 METDI1349 Methylobacterium extorquens DM4 hypothetical protein YP_003066953.1 1225930 R 661410 CDS YP_003066954.1 254559859 8191580 complement(1226456..1229620) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 11399769, 12813074, 1711024, 20461235, 21125583, 21178899, 21450803; Product type t : transporter; copper/silver efflux system, membrane component 1229620 cusA 8191580 cusA Methylobacterium extorquens DM4 copper/silver efflux system, membrane component YP_003066954.1 1226456 R 661410 CDS YP_003066955.1 254559860 8195230 complement(1229617..1231143) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative secretion protein, putative RND family efflux protein 1231143 8195230 METDI1351 Methylobacterium extorquens DM4 putative secretion protein, putative RND family efflux protein YP_003066955.1 1229617 R 661410 CDS YP_003066956.1 254559861 8191581 complement(1231143..1231691) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1231691 8191581 METDI1352 Methylobacterium extorquens DM4 hypothetical protein YP_003066956.1 1231143 R 661410 CDS YP_003066957.1 254559862 8191582 complement(1231936..1232337) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1232337 8191582 METDI1353 Methylobacterium extorquens DM4 hypothetical protein YP_003066957.1 1231936 R 661410 CDS YP_003066958.1 254559863 8191583 complement(1232474..1232812) 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 1232812 8191583 METDI1354 Methylobacterium extorquens DM4 hypothetical protein YP_003066958.1 1232474 R 661410 CDS YP_003066959.1 254559864 8191584 1233358..1233576 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1233576 8191584 METDI1355 Methylobacterium extorquens DM4 hypothetical protein YP_003066959.1 1233358 D 661410 CDS YP_003066960.1 254559865 8191585 1233616..1233888 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 1233888 8191585 METDI1356 Methylobacterium extorquens DM4 hypothetical protein YP_003066960.1 1233616 D 661410 CDS YP_003066961.1 254559866 8191586 complement(1233933..1234583) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1234583 8191586 METDI1357 Methylobacterium extorquens DM4 hypothetical protein YP_003066961.1 1233933 R 661410 CDS YP_003066962.1 254559867 8191587 complement(1234580..1235188) 1 NC_012988.1 Bacteria have multiple sigma factors which are active under specific conditions; the sigma factor binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; RNA polymerase sigma factor 1235188 8191587 METDI1358 Methylobacterium extorquens DM4 RNA polymerase sigma factor YP_003066962.1 1234580 R 661410 CDS YP_003066963.1 254559868 8191588 complement(1235603..1235818) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1235818 8191588 METDI1359 Methylobacterium extorquens DM4 hypothetical protein YP_003066963.1 1235603 R 661410 CDS YP_003066964.1 254559869 8191589 1236147..1236518 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1236518 8191589 METDI1360 Methylobacterium extorquens DM4 hypothetical protein YP_003066964.1 1236147 D 661410 CDS YP_003066965.1 254559870 8191590 1237825..1238259 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1238259 8191590 METDI1361 Methylobacterium extorquens DM4 hypothetical protein YP_003066965.1 1237825 D 661410 CDS YP_003066966.1 254559871 8191591 1238328..1238750 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1238750 8191591 METDI1362 Methylobacterium extorquens DM4 hypothetical protein YP_003066966.1 1238328 D 661410 CDS YP_003066967.1 254559872 8191592 1238813..1240357 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative outer membrane efflux protein; putative copper tolerance protein 1240357 8191592 METDI1363 Methylobacterium extorquens DM4 putative outer membrane efflux protein; putative copper tolerance protein YP_003066967.1 1238813 D 661410 CDS YP_003066968.1 254559873 8191593 1240390..1241811 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 17359266; Product type e : enzyme; multicopper oxidase, putative manganese-oxidizing multicopper oxidase 1241811 8191593 METDI1364 Methylobacterium extorquens DM4 multicopper oxidase, putative manganese-oxidizing multicopper oxidase YP_003066968.1 1240390 D 661410 CDS YP_003066969.1 254559874 8191594 1241986..1242270 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1242270 8191594 METDI1365 Methylobacterium extorquens DM4 hypothetical protein YP_003066969.1 1241986 D 661410 CDS YP_003066970.1 254559875 8191595 1242342..1243046 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1243046 8191595 METDI1366 Methylobacterium extorquens DM4 hypothetical protein YP_003066970.1 1242342 D 661410 CDS YP_003066971.1 254559876 8191596 1243152..1243790 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier; putative cytochrome c family protein precursor 1243790 8191596 METDI1367 Methylobacterium extorquens DM4 putative cytochrome c family protein precursor YP_003066971.1 1243152 D 661410 CDS YP_003066972.1 254559877 8191597 1243924..1244304 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1244304 8191597 METDI1368 Methylobacterium extorquens DM4 hypothetical protein YP_003066972.1 1243924 D 661410 CDS YP_003066973.1 254559878 8191598 1244667..1244954 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 1244954 8191598 METDI1369 Methylobacterium extorquens DM4 hypothetical protein YP_003066973.1 1244667 D 661410 CDS YP_003066974.1 254559879 8191599 complement(1245246..1245557) 1 NC_012988.1 Evidence 6 : Doubtful CDS; Product type e : enzyme; hypothetical protein 1245557 8191599 METDI1370 Methylobacterium extorquens DM4 hypothetical protein YP_003066974.1 1245246 R 661410 CDS YP_003066975.1 254559880 8191600 complement(1245853..1246482) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 15064768; Product type r : regulator; transcriptional regulator, GntR family 1246482 8191600 METDI1371 Methylobacterium extorquens DM4 transcriptional regulator, GntR family YP_003066975.1 1245853 R 661410 CDS YP_003066976.1 254559881 8191601 1246677..1248020 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 7592429; Product type pt : putative transporter; putative tartrate transporter ttuB 1248020 8191601 METDI1372 Methylobacterium extorquens DM4 putative tartrate transporter ttuB YP_003066976.1 1246677 D 661410 CDS YP_003066977.1 254559882 8191602 1248062..1249138 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 10568751, 8969502, 9384377; Product type e : enzyme; Tartrate dehydrogenase/decarboxylase (TDH) (D-malate dehydrogenase [decarboxylating]) 1249138 ttuC 8191602 ttuC Methylobacterium extorquens DM4 Tartrate dehydrogenase/decarboxylase (TDH) (D-malate dehydrogenase [decarboxylating]) YP_003066977.1 1248062 D 661410 CDS YP_003066978.1 254559883 8196287 1249143..1250402 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative glycerate kinase 1250402 8196287 METDI1374 Methylobacterium extorquens DM4 putative glycerate kinase YP_003066978.1 1249143 D 661410 CDS YP_003066979.1 254559884 8191603 1250427..1251854 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 7592429; Product type e : enzyme; pyruvate kinase 1251854 pyk 8191603 pyk Methylobacterium extorquens DM4 pyruvate kinase YP_003066979.1 1250427 D 661410 CDS YP_003066980.1 254559885 8195944 1252306..1252518 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1252518 8195944 METDI1376 Methylobacterium extorquens DM4 hypothetical protein YP_003066980.1 1252306 D 661410 CDS YP_003066981.1 254559886 8191604 complement(1252566..1253312) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 10788346; Product type e : enzyme; NADPH-dependent FMN reductase 1253312 arsH 8191604 arsH Methylobacterium extorquens DM4 NADPH-dependent FMN reductase YP_003066981.1 1252566 R 661410 CDS YP_003066982.1 254559887 8195102 1253363..1254241 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 10788346, 11573087, 12829264, 16905151, 9537360; Product type e : enzyme; bifunctional protein, N-terminal transcriptional regulator, ArsR family and C-terminal arsenate reductase/phosphotyrosine protein phosphatase 1254241 arsRC 8195102 arsRC Methylobacterium extorquens DM4 bifunctional protein, N-terminal transcriptional regulator, ArsR family and C-terminal arsenate reductase/phosphotyrosine protein phosphatase YP_003066982.1 1253363 D 661410 CDS YP_003066983.1 254559888 8195107 1254241..1254666 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 16905151, 17432936; Product type e : enzyme; arsenate reductase (glutaredoxin family) 1254666 arsC 8195107 arsC Methylobacterium extorquens DM4 arsenate reductase (glutaredoxin family) YP_003066983.1 1254241 D 661410 CDS YP_003066984.1 254559889 8195099 1254675..1255742 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type t : transporter; arsenite efflux pump ACR3 1255742 acr3 8195099 acr3 Methylobacterium extorquens DM4 arsenite efflux pump ACR3 YP_003066984.1 1254675 D 661410 CDS YP_003066985.1 254559890 8195053 1255732..1256907 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative Major Facilitator Family (MFS) transporter 1256907 8195053 METDI1381 Methylobacterium extorquens DM4 putative Major Facilitator Family (MFS) transporter YP_003066985.1 1255732 D 661410 CDS YP_003066986.1 254559891 8191605 1257095..1257367 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1257367 8191605 METDI1382 Methylobacterium extorquens DM4 hypothetical protein YP_003066986.1 1257095 D 661410 CDS YP_003066987.1 254559892 8191606 1257522..1259276 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; peptidase S8/S53 subtilisin kexin sedolisin 1259276 8191606 METDI1383 Methylobacterium extorquens DM4 peptidase S8/S53 subtilisin kexin sedolisin YP_003066987.1 1257522 D 661410 CDS YP_003066988.1 254559893 8191607 1259374..1259934 1 NC_012988.1 Bacteria have multiple sigma factors which are active under specific conditions; the sigma factor binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; RNA polymerase sigma factor 1259934 8191607 METDI1384 Methylobacterium extorquens DM4 RNA polymerase sigma factor YP_003066988.1 1259374 D 661410 CDS YP_003066989.1 254559894 8191608 1259921..1260628 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1260628 8191608 METDI1385 Methylobacterium extorquens DM4 hypothetical protein YP_003066989.1 1259921 D 661410 CDS YP_003066990.1 254559895 8191609 1260644..1260952 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1260952 8191609 METDI1386 Methylobacterium extorquens DM4 hypothetical protein YP_003066990.1 1260644 D 661410 CDS YP_003066991.1 254559896 8191612 complement(1262124..1262366) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1262366 8191612 METDI1389 Methylobacterium extorquens DM4 hypothetical protein YP_003066991.1 1262124 R 661410 CDS YP_003066992.1 254559897 8191613 1262800..1263024 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1263024 8191613 METDI1391 Methylobacterium extorquens DM4 hypothetical protein YP_003066992.1 1262800 D 661410 CDS YP_003066993.1 254559898 8191614 1263278..1263562 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1263562 8191614 METDI1392 Methylobacterium extorquens DM4 hypothetical protein YP_003066993.1 1263278 D 661410 CDS YP_003066994.1 254559899 8191615 complement(1263630..1263974) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1263974 8191615 METDI1394 Methylobacterium extorquens DM4 hypothetical protein YP_003066994.1 1263630 R 661410 CDS YP_003066995.1 254559900 8191616 complement(1264163..1264687) 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 1264687 8191616 METDI1395 Methylobacterium extorquens DM4 hypothetical protein YP_003066995.1 1264163 R 661410 CDS YP_003066996.1 254559901 8191617 complement(1264831..1268091) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 7766206; Product type t : transporter; Cation efflux system protein czcA 1268091 czcA 8191617 czcA Methylobacterium extorquens DM4 Cation efflux system protein czcA YP_003066996.1 1264831 R 661410 CDS YP_003066997.1 254559902 8195267 complement(1268103..1269419) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; putative secretion protein, putative RND family efflux protein 1269419 8195267 METDI1397 Methylobacterium extorquens DM4 putative secretion protein, putative RND family efflux protein YP_003066997.1 1268103 R 661410 CDS YP_003066998.1 254559903 8191618 complement(1269567..1269953) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1269953 8191618 METDI1398 Methylobacterium extorquens DM4 hypothetical protein YP_003066998.1 1269567 R 661410 CDS YP_003066999.1 254559904 8191619 complement(1269969..1270379) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1270379 8191619 METDI1399 Methylobacterium extorquens DM4 hypothetical protein YP_003066999.1 1269969 R 661410 CDS YP_003067000.1 254559905 8191620 complement(1270482..1270964) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1270964 8191620 METDI1400 Methylobacterium extorquens DM4 hypothetical protein YP_003067000.1 1270482 R 661410 CDS YP_003067001.1 254559906 8191621 complement(1271062..1271484) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11936079, 12213931; Product type pr : putative regulator; putative transcriptional regulator, MerR family 1271484 8191621 METDI1401 Methylobacterium extorquens DM4 putative transcriptional regulator, MerR family YP_003067001.1 1271062 R 661410 CDS YP_003067002.1 254559907 8191622 1271532..1273682 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 10660539; Product type t : transporter; Zinc, cobalt and lead efflux system (P-type ATPase) 1273682 zntA 8191622 zntA Methylobacterium extorquens DM4 Zinc, cobalt and lead efflux system (P-type ATPase) YP_003067002.1 1271532 D 661410 CDS YP_003067003.1 254559908 8196380 1273695..1274303 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1274303 8196380 METDI1403 Methylobacterium extorquens DM4 hypothetical protein YP_003067003.1 1273695 D 661410 CDS YP_003067004.1 254559909 8191623 1274427..1275095 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1275095 8191623 METDI1404 Methylobacterium extorquens DM4 hypothetical protein YP_003067004.1 1274427 D 661410 CDS YP_003067005.1 254559910 8191624 1275026..1275340 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 1275340 8191624 METDI1405 Methylobacterium extorquens DM4 hypothetical protein YP_003067005.1 1275026 D 661410 CDS YP_003067006.1 254559911 8191626 complement(1276251..1277003) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type e : enzyme; transposase of ISMdi3, IS3 family (ORF 2) 1277003 8191626 METDI1407 Methylobacterium extorquens DM4 transposase of ISMdi3, IS3 family (ORF 2) YP_003067006.1 1276251 R 661410 CDS YP_003067007.1 254559912 8191627 complement(1277111..1277392) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; transposase of ISMdi3, IS3 family (ORF 1) 1277392 8191627 METDI1408 Methylobacterium extorquens DM4 transposase of ISMdi3, IS3 family (ORF 1) YP_003067007.1 1277111 R 661410 CDS YP_003067008.1 254559913 8191629 complement(1278382..1279395) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; transposase of ISMdi14, IS110 family 1279395 8191629 METDI1410 Methylobacterium extorquens DM4 transposase of ISMdi14, IS110 family YP_003067008.1 1278382 R 661410 CDS YP_003067009.1 254559914 8191630 complement(1279792..1280112) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1280112 8191630 METDI1411 Methylobacterium extorquens DM4 hypothetical protein YP_003067009.1 1279792 R 661410 CDS YP_003067010.1 254559915 8191631 complement(1280352..1280507) 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 1280507 8191631 METDI1412 Methylobacterium extorquens DM4 hypothetical protein YP_003067010.1 1280352 R 661410 CDS YP_003067011.1 254559916 8191632 complement(1280610..1282769) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor; putative plasmid stabilization protein (plasmid partitioning) 1282769 8191632 METDI1413 Methylobacterium extorquens DM4 putative plasmid stabilization protein (plasmid partitioning) YP_003067011.1 1280610 R 661410 CDS YP_003067012.1 254559917 8191633 complement(1283121..1284128) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type f : factor; Antirestriction protein (ardC) 1284128 ardC 8191633 ardC Methylobacterium extorquens DM4 Antirestriction protein (ardC) YP_003067012.1 1283121 R 661410 CDS YP_003067013.1 254559918 8191634 complement(1284771..1285856) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type e : enzyme; transposase of ISMdi10, IS110 family 1285856 8191634 METDI1416 Methylobacterium extorquens DM4 transposase of ISMdi10, IS110 family YP_003067013.1 1284771 R 661410 CDS YP_003067014.1 254559919 8191636 complement(1286120..1286362) 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 1286362 8191636 METDI1418 Methylobacterium extorquens DM4 hypothetical protein YP_003067014.1 1286120 R 661410 CDS YP_003067015.1 254559920 8191637 complement(1286323..1286532) 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 1286532 8191637 METDI1419 Methylobacterium extorquens DM4 hypothetical protein YP_003067015.1 1286323 R 661410 CDS YP_003067016.1 254559921 8191638 complement(1286664..1286918) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1286918 8191638 METDI1420 Methylobacterium extorquens DM4 hypothetical protein YP_003067016.1 1286664 R 661410 CDS YP_003067017.1 254559922 8191639 complement(1287150..1287668) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; transposase of ISMdi22, IS5 family 1287668 8191639 METDI1421 Methylobacterium extorquens DM4 transposase of ISMdi22, IS5 family YP_003067017.1 1287150 R 661410 CDS YP_003067018.1 254559923 8191641 complement(1288804..1289829) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; transposase of ISMdi12, IS110 family 1289829 8191641 METDI1423 Methylobacterium extorquens DM4 transposase of ISMdi12, IS110 family YP_003067018.1 1288804 R 661410 CDS YP_003067019.1 254559924 8191642 1289887..1290282 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1290282 8191642 METDI1424 Methylobacterium extorquens DM4 hypothetical protein YP_003067019.1 1289887 D 661410 CDS YP_003067020.1 254559925 8191643 1290482..1290760 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1290760 8191643 METDI1425 Methylobacterium extorquens DM4 hypothetical protein YP_003067020.1 1290482 D 661410 CDS YP_003067021.1 254559926 8191644 1291281..1293413 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1293413 8191644 METDI1426 Methylobacterium extorquens DM4 hypothetical protein YP_003067021.1 1291281 D 661410 CDS YP_003067022.1 254559927 8191645 complement(1293490..1293780) 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 1293780 8191645 METDI1427 Methylobacterium extorquens DM4 hypothetical protein YP_003067022.1 1293490 R 661410 CDS YP_003067023.1 254559928 8191646 complement(1294532..1294867) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1294867 8191646 METDI1428 Methylobacterium extorquens DM4 hypothetical protein YP_003067023.1 1294532 R 661410 CDS YP_003067024.1 254559929 8191647 1295178..1296317 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type e : enzyme; transposase of ISMdi9, IS110 family 1296317 8191647 METDI1429 Methylobacterium extorquens DM4 transposase of ISMdi9, IS110 family YP_003067024.1 1295178 D 661410 CDS YP_003067025.1 254559930 8191648 complement(1296961..1297770) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 8594334; Product type t : transporter; Copper resistance protein CopB precursor 1297770 copB 8191648 copB Methylobacterium extorquens DM4 Copper resistance protein CopB precursor YP_003067025.1 1296961 R 661410 CDS YP_003067026.1 254559931 8195202 complement(1297781..1299859) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; Copper resistance protein A precursor 1299859 copA 8195202 copA Methylobacterium extorquens DM4 Copper resistance protein A precursor YP_003067026.1 1297781 R 661410 CDS YP_003067027.1 254559932 8195201 1300326..1300520 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1300520 8195201 METDI1433 Methylobacterium extorquens DM4 hypothetical protein YP_003067027.1 1300326 D 661410 CDS YP_003067028.1 254559933 8191649 1300462..1300725 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor; putative periplasmic copper-binding protein (cusF-like domain) 1300725 8191649 METDI1434 Methylobacterium extorquens DM4 putative periplasmic copper-binding protein (cusF-like domain) YP_003067028.1 1300462 D 661410 CDS YP_003067029.1 254559934 8191650 1300973..1301329 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1301329 8191650 METDI1435 Methylobacterium extorquens DM4 hypothetical protein YP_003067029.1 1300973 D 661410 CDS YP_003067030.1 254559935 8191651 1301360..1301827 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1301827 8191651 METDI1436 Methylobacterium extorquens DM4 hypothetical protein YP_003067030.1 1301360 D 661410 CDS YP_003067031.1 254559936 8191652 complement(1301770..1302492) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative Transcriptional regulator, Crp/Fnr family 1302492 8191652 METDI1437 Methylobacterium extorquens DM4 putative Transcriptional regulator, Crp/Fnr family YP_003067031.1 1301770 R 661410 CDS YP_003067032.1 254559937 8191653 1302829..1303440 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1303440 8191653 METDI1438 Methylobacterium extorquens DM4 hypothetical protein YP_003067032.1 1302829 D 661410 CDS YP_003067033.1 254559938 8191654 1303760..1305457 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10651802; Product type pe : putative enzyme; putative HCP oxidoreductase, NADH-dependent (hcr-like domain); ferredoxin reductase-like, C-terminal NADP-linked domain 1305457 8191654 METDI1439 Methylobacterium extorquens DM4 putative HCP oxidoreductase, NADH-dependent (hcr-like domain); ferredoxin reductase-like, C-terminal NADP-linked domain YP_003067033.1 1303760 D 661410 CDS YP_003067034.1 254559939 8191655 1305412..1306209 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1306209 8191655 METDI1440 Methylobacterium extorquens DM4 hypothetical protein YP_003067034.1 1305412 D 661410 CDS YP_003067035.1 254559940 8191656 1306206..1306979 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1306979 8191656 METDI1441 Methylobacterium extorquens DM4 hypothetical protein YP_003067035.1 1306206 D 661410 CDS YP_003067036.1 254559941 8191657 1307896..1308360 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1308360 8191657 METDI1442 Methylobacterium extorquens DM4 hypothetical protein YP_003067036.1 1307896 D 661410 CDS YP_003067037.1 254559942 8191658 complement(1308591..1309685) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; Phosphate acetyltransferase 1309685 pta 8191658 pta Methylobacterium extorquens DM4 Phosphate acetyltransferase YP_003067037.1 1308591 R 661410 CDS YP_003067038.1 254559943 8195914 complement(1309682..1310893) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative acetate kinase, propionate kinase 1310893 8195914 METDI1444 Methylobacterium extorquens DM4 putative acetate kinase, propionate kinase YP_003067038.1 1309682 R 661410 CDS YP_003067039.1 254559944 8191659 complement(1310897..1312708) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1312708 8191659 METDI1445 Methylobacterium extorquens DM4 hypothetical protein YP_003067039.1 1310897 R 661410 CDS YP_003067040.1 254559945 8191660 complement(1312721..1312894) 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 1312894 8191660 METDI1446 Methylobacterium extorquens DM4 hypothetical protein YP_003067040.1 1312721 R 661410 CDS YP_003067041.1 254559946 8191661 complement(1312905..1313594) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; hypothetical protein 1313594 8191661 METDI1447 Methylobacterium extorquens DM4 hypothetical protein YP_003067041.1 1312905 R 661410 CDS YP_003067042.1 254559947 8191662 complement(1313614..1313865) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1313865 8191662 METDI1448 Methylobacterium extorquens DM4 hypothetical protein YP_003067042.1 1313614 R 661410 CDS YP_003067043.1 254559948 8191663 1314044..1314730 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1314730 8191663 METDI1449 Methylobacterium extorquens DM4 hypothetical protein YP_003067043.1 1314044 D 661410 CDS YP_003067044.1 254559949 8191664 1314860..1315027 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 1315027 8191664 METDI1450 Methylobacterium extorquens DM4 hypothetical protein YP_003067044.1 1314860 D 661410 CDS YP_003067045.1 254559950 8191665 1315294..1316736 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1316736 8191665 METDI1451 Methylobacterium extorquens DM4 hypothetical protein YP_003067045.1 1315294 D 661410 CDS YP_003067046.1 254559951 8191666 1316769..1316981 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1316981 8191666 METDI1452 Methylobacterium extorquens DM4 hypothetical protein YP_003067046.1 1316769 D 661410 CDS YP_003067047.1 254559952 8191669 1318235..1318957 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1318957 8191669 METDI1455 Methylobacterium extorquens DM4 hypothetical protein YP_003067047.1 1318235 D 661410 CDS YP_003067048.1 254559953 8191670 1318686..1319057 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1319057 8191670 METDI1456 Methylobacterium extorquens DM4 hypothetical protein YP_003067048.1 1318686 D 661410 CDS YP_003067049.1 254559954 8191671 complement(1319044..1319796) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; transposase of ISMdi3, IS3 family (ORF 2) 1319796 8191671 METDI1457 Methylobacterium extorquens DM4 transposase of ISMdi3, IS3 family (ORF 2) YP_003067049.1 1319044 R 661410 CDS YP_003067050.1 254559955 8191672 complement(1319904..1320185) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type e : enzyme; transposase of ISMdi3, IS3 family (ORF 1) 1320185 8191672 METDI1458 Methylobacterium extorquens DM4 transposase of ISMdi3, IS3 family (ORF 1) YP_003067050.1 1319904 R 661410 CDS YP_003067051.1 254559956 8191674 1320888..1321283 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1321283 8191674 METDI1460 Methylobacterium extorquens DM4 hypothetical protein YP_003067051.1 1320888 D 661410 CDS YP_003067052.1 254559957 8191675 1321375..1322607 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type t : transporter; Transcription regulatory protein 1322607 opdE 8191675 opdE Methylobacterium extorquens DM4 Transcription regulatory protein YP_003067052.1 1321375 D 661410 CDS YP_003067053.1 254559958 8195810 1322679..1323446 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; Short-chain dehydrogenase/reductase SDR 1323446 8195810 METDI1462 Methylobacterium extorquens DM4 Short-chain dehydrogenase/reductase SDR YP_003067053.1 1322679 D 661410 CDS YP_003067054.1 254559959 8191676 1323590..1323961 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1323961 8191676 METDI1463 Methylobacterium extorquens DM4 hypothetical protein YP_003067054.1 1323590 D 661410 CDS YP_003067055.1 254559960 8191677 1323972..1325027 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11418146, 17166853; Product type pe : putative enzyme; putative lactonase precursor 1325027 8191677 METDI1464 Methylobacterium extorquens DM4 putative lactonase precursor YP_003067055.1 1323972 D 661410 CDS YP_003067056.1 254559961 8191678 1325091..1325702 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1325702 8191678 METDI1465 Methylobacterium extorquens DM4 hypothetical protein YP_003067056.1 1325091 D 661410 CDS YP_003067057.1 254559962 8191679 1325474..1325977 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 1325977 8191679 METDI1466 Methylobacterium extorquens DM4 hypothetical protein YP_003067057.1 1325474 D 661410 CDS YP_003067058.1 254559963 8191680 1325808..1326467 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative short-chain dehydrogenase/reductase SDR 1326467 8191680 METDI1467 Methylobacterium extorquens DM4 putative short-chain dehydrogenase/reductase SDR YP_003067058.1 1325808 D 661410 CDS YP_003067059.1 254559964 8191681 complement(1326480..1327373) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcriptional regulator, LysR family 1327373 8191681 METDI1468 Methylobacterium extorquens DM4 putative transcriptional regulator, LysR family YP_003067059.1 1326480 R 661410 CDS YP_003067060.1 254559965 8191682 1327666..1328256 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; oxidoreductase, 2Fe-2S subunit 1328256 8191682 METDI1469 Methylobacterium extorquens DM4 oxidoreductase, 2Fe-2S subunit YP_003067060.1 1327666 D 661410 CDS YP_003067061.1 254559966 8191683 1328040..1329203 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; oxidoreductase, FAD-binding subunit 1329203 8191683 METDI1470 Methylobacterium extorquens DM4 oxidoreductase, FAD-binding subunit YP_003067061.1 1328040 D 661410 CDS YP_003067062.1 254559967 8191684 1329207..1331426 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; oxidoreductase, molybdopterin-binding subunit 1331426 8191684 METDI1471 Methylobacterium extorquens DM4 oxidoreductase, molybdopterin-binding subunit YP_003067062.1 1329207 D 661410 CDS YP_003067063.1 254559968 8191685 1331604..1331930 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1331930 8191685 METDI1472 Methylobacterium extorquens DM4 hypothetical protein YP_003067063.1 1331604 D 661410 CDS YP_003067064.1 254559969 8191686 1331985..1332161 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1332161 8191686 METDI1473 Methylobacterium extorquens DM4 hypothetical protein YP_003067064.1 1331985 D 661410 CDS YP_003067065.1 254559970 8191687 1332237..1332638 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 1332638 8191687 MEDTI5946 Methylobacterium extorquens DM4 hypothetical protein YP_003067065.1 1332237 D 661410 CDS YP_003067066.1 254559971 8190528 1332884..1333234 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1333234 8190528 METDI1474 Methylobacterium extorquens DM4 hypothetical protein YP_003067066.1 1332884 D 661410 CDS YP_003067067.1 254559972 8191688 1333806..1334840 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative GTPase 1334840 8191688 METDI1475 Methylobacterium extorquens DM4 putative GTPase YP_003067067.1 1333806 D 661410 CDS YP_003067068.1 254559973 8196086 complement(1341266..1342435) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 1342435 8196086 METDI1481 Methylobacterium extorquens DM4 putative NADH dehydrogenase (ubiquinone) 1 alpha subcomplex YP_003067068.1 1341266 R 661410 CDS YP_003067069.1 254559974 8191690 complement(1342676..1343341) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1343341 8191690 METDI1482 Methylobacterium extorquens DM4 hypothetical protein YP_003067069.1 1342676 R 661410 CDS YP_003067070.1 254559975 8191691 1343583..1344752 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 9603882; Product type pt : putative transporter; putative transporter, major facilitator superfamily 1344752 8191691 METDI1483 Methylobacterium extorquens DM4 putative transporter, major facilitator superfamily YP_003067070.1 1343583 D 661410 CDS YP_003067071.1 254559976 8191692 1344836..1347013 1 NC_012988.1 binding of PriA to forked DNA starts the assembly of the primosome, also possesses 3'-5' helicase activity; primosome assembly protein PriA 1347013 priA 8191692 priA Methylobacterium extorquens DM4 primosome assembly protein PriA YP_003067071.1 1344836 D 661410 CDS YP_003067072.1 254559977 8195897 1347098..1347460 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1347460 8195897 METDI1485 Methylobacterium extorquens DM4 hypothetical protein YP_003067072.1 1347098 D 661410 CDS YP_003067073.1 254559978 8191693 complement(1347549..1347929) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1347929 8191693 METDI1486 Methylobacterium extorquens DM4 hypothetical protein YP_003067073.1 1347549 R 661410 CDS YP_003067074.1 254559979 8191694 complement(1348352..1348603) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1348603 8191694 METDI1487 Methylobacterium extorquens DM4 hypothetical protein YP_003067074.1 1348352 R 661410 CDS YP_003067075.1 254559980 8191695 complement(1348721..1349731) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative short-chain dehydrogenase/reductase SDR 1349731 8191695 METDI1488 Methylobacterium extorquens DM4 putative short-chain dehydrogenase/reductase SDR YP_003067075.1 1348721 R 661410 CDS YP_003067076.1 254559981 8191696 complement(1349877..1350488) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative Isochorismatase hydrolase 1350488 8191696 METDI1489 Methylobacterium extorquens DM4 putative Isochorismatase hydrolase YP_003067076.1 1349877 R 661410 CDS YP_003067077.1 254559982 8191697 complement(1350521..1351645) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative zinc-containing alcohol dehydrogenase 1351645 8191697 METDI1490 Methylobacterium extorquens DM4 putative zinc-containing alcohol dehydrogenase YP_003067077.1 1350521 R 661410 CDS YP_003067078.1 254559983 8191698 complement(1351823..1352431) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1352431 8191698 METDI1491 Methylobacterium extorquens DM4 hypothetical protein YP_003067078.1 1351823 R 661410 CDS YP_003067079.1 254559984 8191699 1352697..1353509 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; Short-chain dehydrogenase/reductase SDR 1353509 8191699 METDI1492 Methylobacterium extorquens DM4 Short-chain dehydrogenase/reductase SDR YP_003067079.1 1352697 D 661410 CDS YP_003067080.1 254559985 8191700 1353577..1354569 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative short-chain dehydrogenase/reductase SDR 1354569 8191700 METDI1493 Methylobacterium extorquens DM4 putative short-chain dehydrogenase/reductase SDR YP_003067080.1 1353577 D 661410 CDS YP_003067081.1 254559986 8191701 1354652..1354831 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 1354831 8191701 METDI1494 Methylobacterium extorquens DM4 hypothetical protein YP_003067081.1 1354652 D 661410 CDS YP_003067082.1 254559987 8191702 complement(1354969..1356600) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative ubiquinone biosynthesis protein 1356600 8191702 METDI1495 Methylobacterium extorquens DM4 putative ubiquinone biosynthesis protein YP_003067082.1 1354969 R 661410 CDS YP_003067083.1 254559988 8191703 complement(1356761..1357240) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1357240 8191703 METDI1496 Methylobacterium extorquens DM4 hypothetical protein YP_003067083.1 1356761 R 661410 CDS YP_003067084.1 254559989 8196087 1363666..1365759 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; Peptidase M23B 1365759 8196087 METDI1502 Methylobacterium extorquens DM4 Peptidase M23B YP_003067084.1 1363666 D 661410 CDS YP_003067085.1 254559990 8191705 complement(1365782..1366276) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1366276 8191705 METDI1503 Methylobacterium extorquens DM4 hypothetical protein YP_003067085.1 1365782 R 661410 CDS YP_003067086.1 254559991 8191706 complement(1366361..1367254) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative glutamyl-tRNA synthetase 1367254 8191706 METDI1504 Methylobacterium extorquens DM4 putative glutamyl-tRNA synthetase YP_003067086.1 1366361 R 661410 CDS YP_003067087.1 254559992 8191707 complement(1367285..1367584) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1367584 8191707 METDI1505 Methylobacterium extorquens DM4 hypothetical protein YP_003067087.1 1367285 R 661410 CDS YP_003067088.1 254559993 8191708 1367808..1368026 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1368026 8191708 METDI1506 Methylobacterium extorquens DM4 hypothetical protein YP_003067088.1 1367808 D 661410 CDS YP_003067089.1 254559994 8191709 complement(1368049..1369929) 1 NC_012988.1 molecular chaperone; heat shock protein 90 1369929 htpG 8191709 htpG Methylobacterium extorquens DM4 heat shock protein 90 YP_003067089.1 1368049 R 661410 CDS YP_003067090.1 254559995 8195582 complement(1370084..1370275) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1370275 8195582 METDI1508 Methylobacterium extorquens DM4 hypothetical protein YP_003067090.1 1370084 R 661410 CDS YP_003067091.1 254559996 8191710 1370714..1372309 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative gamma-glutamyltranspeptidase 1372309 8191710 METDI1509 Methylobacterium extorquens DM4 putative gamma-glutamyltranspeptidase YP_003067091.1 1370714 D 661410 CDS YP_003067092.1 254559997 8191711 1372412..1374049 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 12966101, 7635824; Product type e : enzyme; Dihydroxyacetone kinase (Glycerone kinase) 1374049 dhaK 8191711 dhaK Methylobacterium extorquens DM4 Dihydroxyacetone kinase (Glycerone kinase) YP_003067092.1 1372412 D 661410 CDS YP_003067093.1 254559998 8195294 1374058..1374906 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative methyltransferase 1374906 8195294 METDI1511 Methylobacterium extorquens DM4 putative methyltransferase YP_003067093.1 1374058 D 661410 CDS YP_003067094.1 254559999 8191712 1374962..1376254 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type t : transporter; oxalate/formate antiporter 1376254 oxlT 8191712 oxlT Methylobacterium extorquens DM4 oxalate/formate antiporter YP_003067094.1 1374962 D 661410 CDS YP_003067095.1 254560000 8195816 1376373..1377608 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 1732195, 2211521; Product type e : enzyme; Precorrin-6Y C(5,15)-methyltransferase [decarboxylating] (Precorrin-6 methyltransferase) (Precorrin-6Y methylase) 1377608 cobL 8195816 cobL Methylobacterium extorquens DM4 Precorrin-6Y C(5,15)-methyltransferase [decarboxylating] (Precorrin-6 methyltransferase) (Precorrin-6Y methylase) YP_003067095.1 1376373 D 661410 CDS YP_003067096.1 254560001 8195192 1377587..1378012 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative cobalamin biosynthesis protein 1378012 8195192 METDI1514 Methylobacterium extorquens DM4 putative cobalamin biosynthesis protein YP_003067096.1 1377587 D 661410 CDS YP_003067097.1 254560002 8191713 1378101..1379192 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative diguanylate cyclase; two GGDEF domains 1379192 8191713 METDI1515 Methylobacterium extorquens DM4 putative diguanylate cyclase; two GGDEF domains YP_003067097.1 1378101 D 661410 CDS YP_003067098.1 254560003 8191714 complement(1379267..1380175) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcriptional regulator (LysR family) 1380175 8191714 METDI1516 Methylobacterium extorquens DM4 putative transcriptional regulator (LysR family) YP_003067098.1 1379267 R 661410 CDS YP_003067099.1 254560004 8191715 1380285..1380728 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1380728 8191715 METDI1517 Methylobacterium extorquens DM4 hypothetical protein YP_003067099.1 1380285 D 661410 CDS YP_003067100.1 254560005 8191716 1380808..1381608 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 2211521, 8226690; Product type e : enzyme; Precorrin-4 C(11)-methyltransferase (Precorrin-3 methylase) 1381608 cobM 8191716 cobM Methylobacterium extorquens DM4 Precorrin-4 C(11)-methyltransferase (Precorrin-3 methylase) YP_003067100.1 1380808 D 661410 CDS YP_003067101.1 254560006 8195193 1381605..1382930 1 NC_012988.1 responsible for the amidation of carboxylic groups at position A and C of cobyrinic acid or hydrogenobrynic acid; cobyrinic acid a,c-diamide synthase 1382930 cobB 8195193 cobB Methylobacterium extorquens DM4 cobyrinic acid a,c-diamide synthase YP_003067101.1 1381605 D 661410 CDS YP_003067102.1 254560007 8195182 complement(1383196..1383624) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcriptional regulator, XRE family 1383624 8195182 METDI1520 Methylobacterium extorquens DM4 putative transcriptional regulator, XRE family YP_003067102.1 1383196 R 661410 CDS YP_003067103.1 254560008 8191717 complement(1383830..1384024) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1384024 8191717 METDI1521 Methylobacterium extorquens DM4 hypothetical protein YP_003067103.1 1383830 R 661410 CDS YP_003067104.1 254560009 8191718 1384075..1384410 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1384410 8191718 METDI1522 Methylobacterium extorquens DM4 hypothetical protein YP_003067104.1 1384075 D 661410 CDS YP_003067105.1 254560010 8191719 complement(1384564..1385811) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type t : transporter; multidrug transport protein (MFS family) 1385811 fsr 8191719 fsr Methylobacterium extorquens DM4 multidrug transport protein (MFS family) YP_003067105.1 1384564 R 661410 CDS YP_003067106.1 254560011 8195445 1386242..1387747 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative glycosyl transferase 1387747 8195445 METDI1524 Methylobacterium extorquens DM4 putative glycosyl transferase YP_003067106.1 1386242 D 661410 CDS YP_003067107.1 254560012 8191720 complement(1387751..1388338) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcriptional regulator, Fur family; zinc uptake regulator ZUR 1388338 8191720 METDI1525 Methylobacterium extorquens DM4 putative transcriptional regulator, Fur family; zinc uptake regulator ZUR YP_003067107.1 1387751 R 661410 CDS YP_003067108.1 254560013 8191721 1388685..1389596 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type t : transporter; ABC transporter, ATP-binding protein 1389596 8191721 METDI1526 Methylobacterium extorquens DM4 ABC transporter, ATP-binding protein YP_003067108.1 1388685 D 661410 CDS YP_003067109.1 254560014 8191722 1389650..1390480 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type t : transporter; ABC family transporter permease protein 1390480 8191722 METDI1527 Methylobacterium extorquens DM4 ABC family transporter permease protein YP_003067109.1 1389650 D 661410 CDS YP_003067110.1 254560015 8191723 1391116..1394637 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 14762018; Product type e : enzyme; DNA polymerase III, alpha subunit 1394637 dnaE 8191723 dnaE Methylobacterium extorquens DM4 DNA polymerase III, alpha subunit YP_003067110.1 1391116 D 661410 CDS YP_003067111.1 254560016 8195304 1394959..1395744 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative membrane bound lytic murein transglycosylase B, mltB 1395744 8195304 METDI1529 Methylobacterium extorquens DM4 putative membrane bound lytic murein transglycosylase B, mltB YP_003067111.1 1394959 D 661410 CDS YP_003067112.1 254560017 8191724 complement(1395860..1396555) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative cation transport protein (ChaC) 1396555 8191724 METDI1530 Methylobacterium extorquens DM4 putative cation transport protein (ChaC) YP_003067112.1 1395860 R 661410 CDS YP_003067113.1 254560018 8191725 complement(1396634..1396837) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1396837 8191725 METDI1531 Methylobacterium extorquens DM4 hypothetical protein YP_003067113.1 1396634 R 661410 CDS YP_003067114.1 254560019 8191726 complement(1396800..1397192) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1397192 8191726 METDI1532 Methylobacterium extorquens DM4 hypothetical protein YP_003067114.1 1396800 R 661410 CDS YP_003067115.1 254560020 8191727 1397321..1398061 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 11743007, 12769856, 1537800, 25401, 94179089, 94266719, 95058623, 98196719; Product type cp : cell process; DNA repair protein RecO 1398061 recO 8191727 recO Methylobacterium extorquens DM4 DNA repair protein RecO YP_003067115.1 1397321 D 661410 CDS YP_003067116.1 254560021 8195973 1398183..1400429 1 NC_012988.1 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling; DNA topoisomerase IV subunit A 1400429 parC 8195973 parC Methylobacterium extorquens DM4 DNA topoisomerase IV subunit A YP_003067116.1 1398183 D 661410 CDS YP_003067117.1 254560022 8195828 complement(1400507..1400764) 1 NC_012988.1 stimulates the activities of the other two initiation factors, IF-2 and IF-3; translation initiation factor IF-1 1400764 infA 8195828 infA Methylobacterium extorquens DM4 translation initiation factor IF-1 YP_003067117.1 1400507 R 661410 CDS YP_003067118.1 254560023 8195597 complement(1401100..1402212) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative extracellular ligand-binding receptor 1402212 8195597 METDI1536 Methylobacterium extorquens DM4 putative extracellular ligand-binding receptor YP_003067118.1 1401100 R 661410 CDS YP_003067119.1 254560024 8191728 1402382..1402705 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1402705 8191728 METDI1537 Methylobacterium extorquens DM4 hypothetical protein YP_003067119.1 1402382 D 661410 CDS YP_003067120.1 254560025 8191729 1402930..1403646 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1403646 8191729 METDI1538 Methylobacterium extorquens DM4 hypothetical protein YP_003067120.1 1402930 D 661410 CDS YP_003067121.1 254560026 8191730 1403651..1404661 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1404661 8191730 METDI1539 Methylobacterium extorquens DM4 hypothetical protein YP_003067121.1 1403651 D 661410 CDS YP_003067122.1 254560027 8191731 1404648..1405241 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1405241 8191731 METDI1540 Methylobacterium extorquens DM4 hypothetical protein YP_003067122.1 1404648 D 661410 CDS YP_003067123.1 254560028 8191732 complement(1405263..1405385) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1405385 8191732 METDI1541 Methylobacterium extorquens DM4 hypothetical protein YP_003067123.1 1405263 R 661410 CDS YP_003067124.1 254560029 8191733 complement(1405631..1406497) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative Formyl transferase (fmt-like) 1406497 8191733 METDI1542 Methylobacterium extorquens DM4 putative Formyl transferase (fmt-like) YP_003067124.1 1405631 R 661410 CDS YP_003067125.1 254560030 8191734 1406662..1407396 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12524213, 7704278, 9405410; Product type pe : putative enzyme; putative short-chain dehydrogenase/reductase 1407396 8191734 METDI1543 Methylobacterium extorquens DM4 putative short-chain dehydrogenase/reductase YP_003067125.1 1406662 D 661410 CDS YP_003067126.1 254560031 8191735 complement(1407455..1408216) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1408216 8191735 METDI1544 Methylobacterium extorquens DM4 hypothetical protein YP_003067126.1 1407455 R 661410 CDS YP_003067127.1 254560032 8191736 1408504..1409100 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1409100 8191736 METDI1545 Methylobacterium extorquens DM4 hypothetical protein YP_003067127.1 1408504 D 661410 CDS YP_003067128.1 254560033 8191737 complement(1409305..1410015) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type t : transporter; outer membrane-specific lipoprotein transporter subunit ; ATP-binding component of ABC superfamily 1410015 lolD 8191737 lolD Methylobacterium extorquens DM4 outer membrane-specific lipoprotein transporter subunit ; ATP-binding component of ABC superfamily YP_003067128.1 1409305 R 661410 CDS YP_003067129.1 254560034 8195641 complement(1410031..1411350) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative Lipoprotein releasing system, transmembrane protein, LolC/E family 1411350 8195641 METDI1547 Methylobacterium extorquens DM4 putative Lipoprotein releasing system, transmembrane protein, LolC/E family YP_003067129.1 1410031 R 661410 CDS YP_003067130.1 254560035 8191738 complement(1411363..1412691) 1 NC_012988.1 catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro); prolyl-tRNA synthetase 1412691 proS 8191738 proS Methylobacterium extorquens DM4 prolyl-tRNA synthetase YP_003067130.1 1411363 R 661410 CDS YP_003067131.1 254560036 8195904 complement(1413164..1413505) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1413505 8195904 METDI1549 Methylobacterium extorquens DM4 hypothetical protein YP_003067131.1 1413164 R 661410 CDS YP_003067132.1 254560037 8191739 complement(1413571..1413975) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 18819910; Product type e : enzyme; ethylmalonyl-CoA/methylmalonyl-CoA epimerase 1413975 epi 8191739 epi Methylobacterium extorquens DM4 ethylmalonyl-CoA/methylmalonyl-CoA epimerase YP_003067132.1 1413571 R 661410 CDS YP_003067133.1 254560038 8195331 complement(1414128..1415801) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative hydrolase, metallo-beta-lactamase superfamily 1415801 8195331 METDI1551 Methylobacterium extorquens DM4 putative hydrolase, metallo-beta-lactamase superfamily YP_003067133.1 1414128 R 661410 CDS YP_003067134.1 254560039 8191740 complement(1415821..1416660) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative biotin-protein ligase (birA-like) 1416660 8191740 METDI1552 Methylobacterium extorquens DM4 putative biotin-protein ligase (birA-like) YP_003067134.1 1415821 R 661410 CDS YP_003067135.1 254560040 8191741 complement(1416680..1418119) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; NADH-quinone oxidoreductase chain N (NADH dehydrogenase I, chain N) 1418119 nuoN 8191741 nuoN Methylobacterium extorquens DM4 NADH-quinone oxidoreductase chain N (NADH dehydrogenase I, chain N) YP_003067135.1 1416680 R 661410 CDS YP_003067136.1 254560041 8195800 complement(1418116..1419699) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; NADH-quinone oxidoreductase chain M (NADH dehydrogenase I, chain M) 1419699 nuoM 8195800 nuoM Methylobacterium extorquens DM4 NADH-quinone oxidoreductase chain M (NADH dehydrogenase I, chain M) YP_003067136.1 1418116 R 661410 CDS YP_003067137.1 254560042 8195799 complement(1419699..1421810) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; NADH-quinone oxidoreductase chain L (NADH dehydrogenase I, chain L) 1421810 nuoL 8195799 nuoL Methylobacterium extorquens DM4 NADH-quinone oxidoreductase chain L (NADH dehydrogenase I, chain L) YP_003067137.1 1419699 R 661410 CDS YP_003067138.1 254560043 8195798 complement(1421869..1422174) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; NADH-quinone oxidoreductase chain K (NADH dehydrogenase I, chain K) 1422174 nuoK 8195798 nuoK Methylobacterium extorquens DM4 NADH-quinone oxidoreductase chain K (NADH dehydrogenase I, chain K) YP_003067138.1 1421869 R 661410 CDS YP_003067139.1 254560044 8195797 complement(1422180..1422800) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; NADH-quinone oxidoreductase chain J (NADH dehydrogenase I, chain J) 1422800 nuoJ 8195797 nuoJ Methylobacterium extorquens DM4 NADH-quinone oxidoreductase chain J (NADH dehydrogenase I, chain J) YP_003067139.1 1422180 R 661410 CDS YP_003067140.1 254560045 8195796 complement(1423010..1423498) 1 NC_012988.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit I 1423498 nuoI 8195796 nuoI Methylobacterium extorquens DM4 NADH dehydrogenase subunit I YP_003067140.1 1423010 R 661410 CDS YP_003067141.1 254560046 8195795 complement(1423583..1424605) 1 NC_012988.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit H 1424605 nuoH 8195795 nuoH Methylobacterium extorquens DM4 NADH dehydrogenase subunit H YP_003067141.1 1423583 R 661410 CDS YP_003067142.1 254560047 8195794 complement(1424618..1426684) 1 NC_012988.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit G 1426684 nuoG 8195794 nuoG Methylobacterium extorquens DM4 NADH dehydrogenase subunit G YP_003067142.1 1424618 R 661410 CDS YP_003067143.1 254560048 8195793 complement(1426719..1428020) 1 NC_012988.1 part of NADH-ubiquinone oxidoreductase complex I; shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain; NuoF is part of the soluble NADH dehydrogenase fragment, which represents the electron input part of NADH dehydrogenase; NADH dehydrogenase I subunit F 1428020 nuoF 8195793 nuoF Methylobacterium extorquens DM4 NADH dehydrogenase I subunit F YP_003067143.1 1426719 R 661410 CDS YP_003067144.1 254560049 8195792 complement(1428031..1429269) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; NADH-quinone oxidoreductase chain E (NADH dehydrogenase I, chain E) 1429269 nuoE 8195792 nuoE Methylobacterium extorquens DM4 NADH-quinone oxidoreductase chain E (NADH dehydrogenase I, chain E) YP_003067144.1 1428031 R 661410 CDS YP_003067145.1 254560050 8195791 complement(1429288..1430478) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; NADH-quinone oxidoreductase chain D (NADH dehydrogenase I, chain D) 1430478 nuoD 8195791 nuoD Methylobacterium extorquens DM4 NADH-quinone oxidoreductase chain D (NADH dehydrogenase I, chain D) YP_003067145.1 1429288 R 661410 CDS YP_003067146.1 254560051 8195790 complement(1430490..1431164) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; NADH-quinone oxidoreductase chain C (NADH dehydrogenase I, chain C) 1431164 nuoC 8195790 nuoC Methylobacterium extorquens DM4 NADH-quinone oxidoreductase chain C (NADH dehydrogenase I, chain C) YP_003067146.1 1430490 R 661410 CDS YP_003067147.1 254560052 8195789 complement(1431161..1431748) 1 NC_012988.1 The point of entry for the majority of electrons that traverse the respiratory chain eventually resulting in the reduction of oxygen; NADH dehydrogenase subunit B 1431748 nuoB 8195789 nuoB Methylobacterium extorquens DM4 NADH dehydrogenase subunit B YP_003067147.1 1431161 R 661410 CDS YP_003067148.1 254560053 8195788 complement(1431801..1432166) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; NADH-quinone oxidoreductase chain A (NADH dehydrogenase I, chain A) 1432166 nuoA 8195788 nuoA Methylobacterium extorquens DM4 NADH-quinone oxidoreductase chain A (NADH dehydrogenase I, chain A) YP_003067148.1 1431801 R 661410 CDS YP_003067149.1 254560054 8196222 1432998..1433486 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor; putative SCP-like extracellular protein 1433486 8196222 METDI1567 Methylobacterium extorquens DM4 putative SCP-like extracellular protein YP_003067149.1 1432998 D 661410 CDS YP_003067150.1 254560055 8191742 complement(1433532..1433978) 1 NC_012988.1 Evidence 1c : Function experimentally demonstrated in the studied genus; PubMedId : 15299445, 4091802; Product type c : carrier; pseudoazurin 1433978 8191742 METDI1568 Methylobacterium extorquens DM4 pseudoazurin YP_003067150.1 1433532 R 661410 CDS YP_003067151.1 254560056 8191743 1434273..1437746 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 10089390, 9174345; Product type e : enzyme; carbamoyl phosphate synthase, large subunit 1437746 carB 8191743 carB Methylobacterium extorquens DM4 carbamoyl phosphate synthase, large subunit YP_003067151.1 1434273 D 661410 CDS YP_003067152.1 254560057 8195147 1437877..1438359 1 NC_012988.1 necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus; transcription elongation factor GreA 1438359 greA 8195147 greA Methylobacterium extorquens DM4 transcription elongation factor GreA YP_003067152.1 1437877 D 661410 CDS YP_003067153.1 254560058 8195531 1438364..1438864 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1438864 8195531 METDI1571 Methylobacterium extorquens DM4 hypothetical protein YP_003067153.1 1438364 D 661410 CDS YP_003067154.1 254560059 8191744 1438917..1439987 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1439987 8191744 METDI1572 Methylobacterium extorquens DM4 hypothetical protein YP_003067154.1 1438917 D 661410 CDS YP_003067155.1 254560060 8191745 1440138..1441112 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 10947986; Product type e : enzyme; thioredoxin reductase, FAD/NAD(P)-binding 1441112 trxB 8191745 trxB Methylobacterium extorquens DM4 thioredoxin reductase, FAD/NAD(P)-binding YP_003067155.1 1440138 D 661410 CDS YP_003067156.1 254560061 8196285 1441075..1441305 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 1441305 8196285 METDI1574 Methylobacterium extorquens DM4 hypothetical protein YP_003067156.1 1441075 D 661410 CDS YP_003067157.1 254560062 8191746 1441453..1442343 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcriptional regulator, LysR family 1442343 8191746 METDI1575 Methylobacterium extorquens DM4 putative transcriptional regulator, LysR family YP_003067157.1 1441453 D 661410 CDS YP_003067158.1 254560063 8191747 1442460..1442915 1 NC_012988.1 catalyzes the formation of 3-dehydroshikimate from 3-dehydroquinate in chorismate biosynthesis; 3-dehydroquinate dehydratase 1442915 aroQ 8191747 aroQ Methylobacterium extorquens DM4 3-dehydroquinate dehydratase YP_003067158.1 1442460 D 661410 CDS YP_003067159.1 254560064 8195095 1442934..1443404 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 10542197; Product type c : carrier; acetyl-CoA carboxylase, biotin carboxyl carrier protein subunit 1443404 accB 8195095 accB Methylobacterium extorquens DM4 acetyl-CoA carboxylase, biotin carboxyl carrier protein subunit YP_003067159.1 1442934 D 661410 CDS YP_003067160.1 254560065 8195045 1443415..1444782 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 10821865, 7915138; Product type e : enzyme; acetyl CoA carboxylase, biotin carboxylase subunit 1444782 accC 8195045 accC Methylobacterium extorquens DM4 acetyl CoA carboxylase, biotin carboxylase subunit YP_003067160.1 1443415 D 661410 CDS YP_003067161.1 254560066 8195046 1444834..1445541 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 90352297, 91177849; Product type pe : putative enzyme; putative leucyl/phenylalanyl-tRNA-protein transferase 1445541 aat 8195046 aat Methylobacterium extorquens DM4 putative leucyl/phenylalanyl-tRNA-protein transferase YP_003067161.1 1444834 D 661410 CDS YP_003067162.1 254560067 8195042 complement(1445607..1446227) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcriptional regulator, TetR family 1446227 8195042 METDI1580 Methylobacterium extorquens DM4 putative transcriptional regulator, TetR family YP_003067162.1 1445607 R 661410 CDS YP_003067163.1 254560068 8191748 1446275..1446754 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1446754 8191748 METDI1581 Methylobacterium extorquens DM4 hypothetical protein YP_003067163.1 1446275 D 661410 CDS YP_003067164.1 254560069 8191749 complement(1446824..1447483) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1447483 8191749 METDI1582 Methylobacterium extorquens DM4 hypothetical protein YP_003067164.1 1446824 R 661410 CDS YP_003067165.1 254560070 8191750 complement(1447661..1448077) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; NADH:ubiquinone oxidoreductase 17.2 kD subunit 1448077 8191750 METDI1584 Methylobacterium extorquens DM4 NADH:ubiquinone oxidoreductase 17.2 kD subunit YP_003067165.1 1447661 R 661410 CDS YP_003067166.1 254560071 8191751 1448597..1452328 1 NC_012988.1 Catalyzes the rate-limiting step in dNTP synthesis; ribonucleotide-diphosphate reductase subunit alpha 1452328 nrd 8191751 nrd Methylobacterium extorquens DM4 ribonucleotide-diphosphate reductase subunit alpha YP_003067166.1 1448597 D 661410 CDS YP_003067167.1 254560072 8195778 1452662..1455646 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative enzyme with a helicase domain 1455646 8195778 METDI1586 Methylobacterium extorquens DM4 putative enzyme with a helicase domain YP_003067167.1 1452662 D 661410 CDS YP_003067168.1 254560073 8191752 complement(1455827..1457476) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; transposase of ISMex10, ISL3 family 1457476 8191752 METDI1587 Methylobacterium extorquens DM4 transposase of ISMex10, ISL3 family YP_003067168.1 1455827 R 661410 CDS YP_003067169.1 254560074 8191753 1457641..1457886 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; transposase of ISMex5, IS3 family (ORF 1) 1457886 8191753 METDI1588 Methylobacterium extorquens DM4 transposase of ISMex5, IS3 family (ORF 1) YP_003067169.1 1457641 D 661410 CDS YP_003067170.1 254560075 8191757 1460866..1461132 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; transposase of ISMex11, IS3 family (ORF 1) 1461132 8191757 METDI1592 Methylobacterium extorquens DM4 transposase of ISMex11, IS3 family (ORF 1) YP_003067170.1 1460866 D 661410 CDS YP_003067171.1 254560076 8191758 1461129..1461965 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; transposase of ISMex11, IS3 family (ORF 2) 1461965 8191758 METDI1593 Methylobacterium extorquens DM4 transposase of ISMex11, IS3 family (ORF 2) YP_003067171.1 1461129 D 661410 CDS YP_003067172.1 254560077 8191759 complement(1462268..1463398) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; Arylamine N-acetyltransferase 1463398 8191759 METDI1594 Methylobacterium extorquens DM4 Arylamine N-acetyltransferase YP_003067172.1 1462268 R 661410 CDS YP_003067173.1 254560078 8191760 complement(1463827..1464309) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1464309 8191760 METDI1595 Methylobacterium extorquens DM4 hypothetical protein YP_003067173.1 1463827 R 661410 CDS YP_003067174.1 254560079 8191761 1464495..1464791 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1464791 8191761 METDI1596 Methylobacterium extorquens DM4 hypothetical protein YP_003067174.1 1464495 D 661410 CDS YP_003067175.1 254560080 8191762 1464921..1465256 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1465256 8191762 METDI1597 Methylobacterium extorquens DM4 hypothetical protein YP_003067175.1 1464921 D 661410 CDS YP_003067176.1 254560081 8191763 1465357..1465587 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1465587 8191763 METDI1598 Methylobacterium extorquens DM4 hypothetical protein YP_003067176.1 1465357 D 661410 CDS YP_003067177.1 254560082 8191764 1465512..1465847 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1465847 8191764 METDI1599 Methylobacterium extorquens DM4 hypothetical protein YP_003067177.1 1465512 D 661410 CDS YP_003067178.1 254560083 8191765 1465817..1466194 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1466194 8191765 METDI1600 Methylobacterium extorquens DM4 hypothetical protein YP_003067178.1 1465817 D 661410 CDS YP_003067179.1 254560084 8191766 complement(1466239..1467099) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative short-chain dehydrogenase/reductase SDR 1467099 8191766 METDI1601 Methylobacterium extorquens DM4 putative short-chain dehydrogenase/reductase SDR YP_003067179.1 1466239 R 661410 CDS YP_003067180.1 254560085 8191767 1467110..1468039 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcriptional regulator 1468039 8191767 METDI1602 Methylobacterium extorquens DM4 putative transcriptional regulator YP_003067180.1 1467110 D 661410 CDS YP_003067181.1 254560086 8191768 1468331..1470193 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 6389496, 92065796, 93186701, 94068502, 94148987, 9636708, 9643547, 9712851; Product type e : enzyme; protease, ATP-dependent zinc-metallo 1470193 ftsH 8191768 ftsH Methylobacterium extorquens DM4 protease, ATP-dependent zinc-metallo YP_003067181.1 1468331 D 661410 CDS YP_003067182.1 254560087 8195450 complement(1470305..1470736) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1470736 8195450 METDI1604 Methylobacterium extorquens DM4 hypothetical protein YP_003067182.1 1470305 R 661410 CDS YP_003067183.1 254560088 8191769 1471213..1471473 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1471473 8191769 METDI1605 Methylobacterium extorquens DM4 hypothetical protein YP_003067183.1 1471213 D 661410 CDS YP_003067184.1 254560089 8191770 complement(1471612..1472730) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative metallopeptidase, CBS (cystathionine-beta-synthase)domain 1472730 8191770 METDI1606 Methylobacterium extorquens DM4 putative metallopeptidase, CBS (cystathionine-beta-synthase)domain YP_003067184.1 1471612 R 661410 CDS YP_003067185.1 254560090 8191771 1473246..1473431 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1473431 8191771 METDI1607 Methylobacterium extorquens DM4 hypothetical protein YP_003067185.1 1473246 D 661410 CDS YP_003067186.1 254560091 8191772 complement(1473500..1475911) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 8331082, 8331083; Product type e : enzyme; DNA-binding ATP-dependent protease La, induced by heat shock and other stresses 1475911 lon 8191772 lon Methylobacterium extorquens DM4 DNA-binding ATP-dependent protease La, induced by heat shock and other stresses YP_003067186.1 1473500 R 661410 CDS YP_003067187.1 254560092 8195642 complement(1475925..1476332) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor; putative small heat shock protein (HSP20) family 1476332 8195642 METDI1609 Methylobacterium extorquens DM4 putative small heat shock protein (HSP20) family YP_003067187.1 1475925 R 661410 CDS YP_003067188.1 254560093 8191773 complement(1476436..1476639) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1476639 8191773 METDI1610 Methylobacterium extorquens DM4 hypothetical protein YP_003067188.1 1476436 R 661410 CDS YP_003067189.1 254560094 8191774 complement(1476714..1477625) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 12597275; Product type e : enzyme; Molecular chaperone dnaJ family 1477625 8191774 METDI1611 Methylobacterium extorquens DM4 Molecular chaperone dnaJ family YP_003067189.1 1476714 R 661410 CDS YP_003067190.1 254560095 8191775 complement(1477976..1478413) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1478413 8191775 METDI1612 Methylobacterium extorquens DM4 hypothetical protein YP_003067190.1 1477976 R 661410 CDS YP_003067191.1 254560096 8191776 complement(1478467..1479108) 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 1479108 8191776 MEDTI5947 Methylobacterium extorquens DM4 hypothetical protein YP_003067191.1 1478467 R 661410 CDS YP_003067192.1 254560097 8190529 complement(1479132..1479560) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1479560 8190529 METDI1613 Methylobacterium extorquens DM4 hypothetical protein YP_003067192.1 1479132 R 661410 CDS YP_003067193.1 254560098 8191777 complement(1479931..1480299) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1480299 8191777 METDI1614 Methylobacterium extorquens DM4 hypothetical protein YP_003067193.1 1479931 R 661410 CDS YP_003067194.1 254560099 8191778 complement(1480304..1480801) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type f : factor; small heat shock protein 1480801 8191778 METDI1615 Methylobacterium extorquens DM4 small heat shock protein YP_003067194.1 1480304 R 661410 CDS YP_003067195.1 254560100 8191779 complement(1481130..1481411) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1481411 8191779 METDI1616 Methylobacterium extorquens DM4 hypothetical protein YP_003067195.1 1481130 R 661410 CDS YP_003067196.1 254560101 8191780 complement(1481936..1484212) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; glycogen debranching enzyme 1484212 glgX 8191780 glgX Methylobacterium extorquens DM4 glycogen debranching enzyme YP_003067196.1 1481936 R 661410 CDS YP_003067197.1 254560102 8195491 1484434..1484748 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1484748 8195491 METDI1618 Methylobacterium extorquens DM4 hypothetical protein YP_003067197.1 1484434 D 661410 CDS YP_003067198.1 254560103 8191781 1485056..1485283 1 NC_012988.1 Evidence 6 : Doubtful CDS; Product type e : enzyme; hypothetical protein 1485283 8191781 METDI1619 Methylobacterium extorquens DM4 hypothetical protein YP_003067198.1 1485056 D 661410 CDS YP_003067199.1 254560104 8191782 1485445..1485615 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1485615 8191782 METDI1620 Methylobacterium extorquens DM4 hypothetical protein YP_003067199.1 1485445 D 661410 CDS YP_003067200.1 254560105 8191783 complement(1485858..1486109) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1486109 8191783 METDI1621 Methylobacterium extorquens DM4 hypothetical protein YP_003067200.1 1485858 R 661410 CDS YP_003067201.1 254560106 8191784 complement(1486420..1486632) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1486632 8191784 METDI1622 Methylobacterium extorquens DM4 hypothetical protein YP_003067201.1 1486420 R 661410 CDS YP_003067202.1 254560107 8191785 complement(1487067..1487522) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1487522 8191785 METDI1623 Methylobacterium extorquens DM4 hypothetical protein YP_003067202.1 1487067 R 661410 CDS YP_003067203.1 254560108 8191786 1487922..1488152 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1488152 8191786 METDI1624 Methylobacterium extorquens DM4 hypothetical protein YP_003067203.1 1487922 D 661410 CDS YP_003067204.1 254560109 8191788 1488846..1489277 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1489277 8191788 METDI1626 Methylobacterium extorquens DM4 hypothetical protein YP_003067204.1 1488846 D 661410 CDS YP_003067205.1 254560110 8191790 complement(1490424..1493048) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type f : factor; protein disaggregation chaperone 1493048 clpB 8191790 clpB Methylobacterium extorquens DM4 protein disaggregation chaperone YP_003067205.1 1490424 R 661410 CDS YP_003067206.1 254560111 8195170 complement(1493218..1494438) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type r : regulator; signal transduction histidine kinase; GAF domain 1494438 8195170 METDI1629 Methylobacterium extorquens DM4 signal transduction histidine kinase; GAF domain YP_003067206.1 1493218 R 661410 CDS YP_003067207.1 254560112 8191791 1494671..1495084 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 9388228; Product type c : carrier; thioredoxin 1495084 trx 8191791 trx Methylobacterium extorquens DM4 thioredoxin YP_003067207.1 1494671 D 661410 CDS YP_003067208.1 254560113 8196282 complement(1495231..1495563) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1495563 8196282 METDI1631 Methylobacterium extorquens DM4 hypothetical protein YP_003067208.1 1495231 R 661410 CDS YP_003067209.1 254560114 8191792 complement(1496167..1496925) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1496925 8191792 METDI1632 Methylobacterium extorquens DM4 hypothetical protein YP_003067209.1 1496167 R 661410 CDS YP_003067210.1 254560115 8191793 complement(1497360..1497872) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor; putative molecular chaperone, heat shock Hsp20 family 1497872 8191793 METDI1633 Methylobacterium extorquens DM4 putative molecular chaperone, heat shock Hsp20 family YP_003067210.1 1497360 R 661410 CDS YP_003067211.1 254560116 8191794 complement(1497968..1498465) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type f : factor; small heat shock protein 1498465 ibpA 8191794 ibpA Methylobacterium extorquens DM4 small heat shock protein YP_003067211.1 1497968 R 661410 CDS YP_003067212.1 254560117 8195584 complement(1498818..1500236) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative phospholipase D/transphosphatidylase 1500236 8195584 METDI1635 Methylobacterium extorquens DM4 putative phospholipase D/transphosphatidylase YP_003067212.1 1498818 R 661410 CDS YP_003067213.1 254560118 8191795 1501348..1501845 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type f : factor; small heat shock protein 1501845 8191795 METDI1636 Methylobacterium extorquens DM4 small heat shock protein YP_003067213.1 1501348 D 661410 CDS YP_003067214.1 254560119 8191796 1501903..1502460 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor; putative molecular chaperone, heat shock Hsp20 family 1502460 8191796 METDI1637 Methylobacterium extorquens DM4 putative molecular chaperone, heat shock Hsp20 family YP_003067214.1 1501903 D 661410 CDS YP_003067215.1 254560120 8191797 complement(1502560..1502976) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1502976 8191797 METDI1638 Methylobacterium extorquens DM4 hypothetical protein YP_003067215.1 1502560 R 661410 CDS YP_003067216.1 254560121 8191798 1503041..1503340 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1503340 8191798 METDI1639 Methylobacterium extorquens DM4 hypothetical protein YP_003067216.1 1503041 D 661410 CDS YP_003067217.1 254560122 8191799 1503367..1504119 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1504119 8191799 METDI1640 Methylobacterium extorquens DM4 hypothetical protein YP_003067217.1 1503367 D 661410 CDS YP_003067218.1 254560123 8191800 1504262..1504666 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1504666 8191800 METDI1641 Methylobacterium extorquens DM4 hypothetical protein YP_003067218.1 1504262 D 661410 CDS YP_003067219.1 254560124 8191801 1504960..1505970 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 10920254, 11160799, 7651136, 8407802; Product type pm : putative membrane component; RND efflux transporter, membrane fusion protein subunit 1505970 8191801 METDI1642 Methylobacterium extorquens DM4 RND efflux transporter, membrane fusion protein subunit YP_003067219.1 1504960 D 661410 CDS YP_003067220.1 254560125 8191802 1506209..1506769 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1506769 8191802 METDI1643 Methylobacterium extorquens DM4 hypothetical protein YP_003067220.1 1506209 D 661410 CDS YP_003067221.1 254560126 8191803 1506877..1507176 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1507176 8191803 METDI1644 Methylobacterium extorquens DM4 hypothetical protein YP_003067221.1 1506877 D 661410 CDS YP_003067222.1 254560127 8191804 complement(1507388..1507717) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1507717 8191804 METDI1645 Methylobacterium extorquens DM4 hypothetical protein YP_003067222.1 1507388 R 661410 CDS YP_003067223.1 254560128 8191805 1507861..1508112 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1508112 8191805 METDI1646 Methylobacterium extorquens DM4 hypothetical protein YP_003067223.1 1507861 D 661410 CDS YP_003067224.1 254560129 8191806 1508287..1510446 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1510446 8191806 METDI1647 Methylobacterium extorquens DM4 hypothetical protein YP_003067224.1 1508287 D 661410 CDS YP_003067225.1 254560130 8191807 1510446..1510640 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 1510640 8191807 METDI1648 Methylobacterium extorquens DM4 hypothetical protein YP_003067225.1 1510446 D 661410 CDS YP_003067226.1 254560131 8191808 1511291..1511611 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 1511611 8191808 METDI1649 Methylobacterium extorquens DM4 hypothetical protein YP_003067226.1 1511291 D 661410 CDS YP_003067227.1 254560132 8191809 1512111..1512578 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1512578 8191809 METDI1650 Methylobacterium extorquens DM4 hypothetical protein YP_003067227.1 1512111 D 661410 CDS YP_003067228.1 254560133 8191810 1513315..1514073 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1514073 8191810 METDI1651 Methylobacterium extorquens DM4 hypothetical protein YP_003067228.1 1513315 D 661410 CDS YP_003067229.1 254560134 8191811 1514073..1516442 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1516442 8191811 METDI1652 Methylobacterium extorquens DM4 hypothetical protein YP_003067229.1 1514073 D 661410 CDS YP_003067230.1 254560135 8191812 1516384..1517667 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1517667 8191812 METDI1653 Methylobacterium extorquens DM4 hypothetical protein YP_003067230.1 1516384 D 661410 CDS YP_003067231.1 254560136 8191813 1517664..1519508 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1519508 8191813 METDI1654 Methylobacterium extorquens DM4 hypothetical protein YP_003067231.1 1517664 D 661410 CDS YP_003067232.1 254560137 8191816 1520589..1520795 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1520795 8191816 METDI1657 Methylobacterium extorquens DM4 hypothetical protein YP_003067232.1 1520589 D 661410 CDS YP_003067233.1 254560138 8191817 1523061..1523810 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative ion transporter 1523810 8191817 METDI1658 Methylobacterium extorquens DM4 putative ion transporter YP_003067233.1 1523061 D 661410 CDS YP_003067234.1 254560139 8191818 complement(1523893..1524705) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1524705 8191818 METDI1659 Methylobacterium extorquens DM4 hypothetical protein YP_003067234.1 1523893 R 661410 CDS YP_003067235.1 254560140 8191819 1524814..1525389 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; hypothetical protein 1525389 8191819 METDI1660 Methylobacterium extorquens DM4 hypothetical protein YP_003067235.1 1524814 D 661410 CDS YP_003067236.1 254560141 8191820 complement(1525744..1526130) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10368157; Product type pr : putative regulator; putative translational regulator (YjgH-related) 1526130 8191820 METDI1661 Methylobacterium extorquens DM4 putative translational regulator (YjgH-related) YP_003067236.1 1525744 R 661410 CDS YP_003067237.1 254560142 8191821 complement(1526229..1527239) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; NADH:flavin oxidoreductase/NADH oxidase 1527239 8191821 METDI1662 Methylobacterium extorquens DM4 NADH:flavin oxidoreductase/NADH oxidase YP_003067237.1 1526229 R 661410 CDS YP_003067238.1 254560143 8191822 1527435..1528358 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type r : regulator; Transcriptional regulator, LysR family 1528358 8191822 METDI1663 Methylobacterium extorquens DM4 Transcriptional regulator, LysR family YP_003067238.1 1527435 D 661410 CDS YP_003067239.1 254560144 8191823 1528636..1529220 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1529220 8191823 METDI1664 Methylobacterium extorquens DM4 hypothetical protein YP_003067239.1 1528636 D 661410 CDS YP_003067240.1 254560145 8191824 1530039..1530566 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1530566 8191824 METDI1665 Methylobacterium extorquens DM4 hypothetical protein YP_003067240.1 1530039 D 661410 CDS YP_003067241.1 254560146 8191825 complement(1531517..1532392) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8763943; Product type pr : putative regulator; putative transcriptional regulator, LysR family 1532392 8191825 METDI1666 Methylobacterium extorquens DM4 putative transcriptional regulator, LysR family YP_003067241.1 1531517 R 661410 CDS YP_003067242.1 254560147 8191826 1532536..1533492 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type t : transporter; ABC transporter, periplasmic protein; putative taurine transporter 1533492 8191826 METDI1667 Methylobacterium extorquens DM4 ABC transporter, periplasmic protein; putative taurine transporter YP_003067242.1 1532536 D 661410 CDS YP_003067243.1 254560148 8191827 1533600..1534370 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type t : transporter; ABC transporter, permease component; putative taurine transporter 1534370 8191827 METDI1668 Methylobacterium extorquens DM4 ABC transporter, permease component; putative taurine transporter YP_003067243.1 1533600 D 661410 CDS YP_003067244.1 254560149 8191828 1534363..1535142 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type t : transporter; ABC transporter, ATPase; putative taurine transporter 1535142 8191828 METDI1669 Methylobacterium extorquens DM4 ABC transporter, ATPase; putative taurine transporter YP_003067244.1 1534363 D 661410 CDS YP_003067245.1 254560150 8191829 1535142..1535972 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1535972 8191829 METDI1670 Methylobacterium extorquens DM4 hypothetical protein YP_003067245.1 1535142 D 661410 CDS YP_003067246.1 254560151 8191830 1535996..1537846 1 NC_012988.1 catalyzes the hydrolysis of allophanate; allophanate hydrolase 1537846 8191830 METDI1671 Methylobacterium extorquens DM4 allophanate hydrolase YP_003067246.1 1535996 D 661410 CDS YP_003067247.1 254560152 8191831 complement(1538105..1539148) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1539148 8191831 METDI1672 Methylobacterium extorquens DM4 hypothetical protein YP_003067247.1 1538105 R 661410 CDS YP_003067248.1 254560153 8191832 1539359..1540411 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1540411 8191832 METDI1673 Methylobacterium extorquens DM4 hypothetical protein YP_003067248.1 1539359 D 661410 CDS YP_003067249.1 254560154 8191833 complement(1540436..1540609) 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 1540609 8191833 METDI1674 Methylobacterium extorquens DM4 hypothetical protein YP_003067249.1 1540436 R 661410 CDS YP_003067250.1 254560155 8191834 complement(1540587..1542119) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative histidine kinase of the HWE family 1542119 8191834 METDI1675 Methylobacterium extorquens DM4 putative histidine kinase of the HWE family YP_003067250.1 1540587 R 661410 CDS YP_003067251.1 254560156 8191835 complement(1542394..1543059) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative short-chain dehydrogenase/reductase SDR 1543059 8191835 METDI1676 Methylobacterium extorquens DM4 putative short-chain dehydrogenase/reductase SDR YP_003067251.1 1542394 R 661410 CDS YP_003067252.1 254560157 8191836 complement(1543119..1543754) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1543754 8191836 METDI1677 Methylobacterium extorquens DM4 hypothetical protein YP_003067252.1 1543119 R 661410 CDS YP_003067253.1 254560158 8191837 complement(1544026..1544679) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1544679 8191837 METDI1678 Methylobacterium extorquens DM4 hypothetical protein YP_003067253.1 1544026 R 661410 CDS YP_003067254.1 254560159 8191838 complement(1544612..1544815) 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 1544815 8191838 METDI1679 Methylobacterium extorquens DM4 hypothetical protein YP_003067254.1 1544612 R 661410 CDS YP_003067255.1 254560160 8191839 1544970..1545344 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1545344 8191839 METDI1680 Methylobacterium extorquens DM4 hypothetical protein YP_003067255.1 1544970 D 661410 CDS YP_003067256.1 254560161 8191840 1545446..1547356 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 89197799, 94042856, 99229748; Product type t : transporter; potassium uptake protein Kup 1547356 trkD 8191840 trkD Methylobacterium extorquens DM4 potassium uptake protein Kup YP_003067256.1 1545446 D 661410 CDS YP_003067257.1 254560162 8196208 complement(1547415..1547876) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1547876 8196208 METDI1682 Methylobacterium extorquens DM4 hypothetical protein YP_003067257.1 1547415 R 661410 CDS YP_003067258.1 254560163 8191841 complement(1547972..1548181) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1548181 8191841 METDI1683 Methylobacterium extorquens DM4 hypothetical protein YP_003067258.1 1547972 R 661410 CDS YP_003067259.1 254560164 8191842 complement(1548242..1549195) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1549195 8191842 METDI1684 Methylobacterium extorquens DM4 hypothetical protein YP_003067259.1 1548242 R 661410 CDS YP_003067260.1 254560165 8191843 complement(1549480..1549722) 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 1549722 8191843 METDI1685 Methylobacterium extorquens DM4 hypothetical protein YP_003067260.1 1549480 R 661410 CDS YP_003067261.1 254560166 8191844 1550052..1551104 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1551104 8191844 METDI1686 Methylobacterium extorquens DM4 hypothetical protein YP_003067261.1 1550052 D 661410 CDS YP_003067262.1 254560167 8191845 1551139..1552272 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; Metallophosphoesterase 1552272 8191845 METDI1687 Methylobacterium extorquens DM4 Metallophosphoesterase YP_003067262.1 1551139 D 661410 CDS YP_003067263.1 254560168 8191846 complement(1552673..1552933) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1552933 8191846 METDI1688 Methylobacterium extorquens DM4 hypothetical protein YP_003067263.1 1552673 R 661410 CDS YP_003067264.1 254560169 8191847 complement(1552981..1553538) 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 1553538 8191847 METDI1689 Methylobacterium extorquens DM4 hypothetical protein YP_003067264.1 1552981 R 661410 CDS YP_003067265.1 254560170 8191848 complement(1553857..1554354) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1554354 8191848 METDI1690 Methylobacterium extorquens DM4 hypothetical protein YP_003067265.1 1553857 R 661410 CDS YP_003067266.1 254560171 8191849 complement(1554723..1556207) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1556207 8191849 METDI1691 Methylobacterium extorquens DM4 hypothetical protein YP_003067266.1 1554723 R 661410 CDS YP_003067267.1 254560172 8191850 complement(1556327..1556569) 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 1556569 8191850 METDI1692 Methylobacterium extorquens DM4 hypothetical protein YP_003067267.1 1556327 R 661410 CDS YP_003067268.1 254560173 8191851 complement(1556837..1557025) 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 1557025 8191851 METDI1693 Methylobacterium extorquens DM4 hypothetical protein YP_003067268.1 1556837 R 661410 CDS YP_003067269.1 254560174 8191852 1557211..1557396 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 1557396 8191852 METDI1694 Methylobacterium extorquens DM4 hypothetical protein YP_003067269.1 1557211 D 661410 CDS YP_003067270.1 254560175 8191853 1558203..1558742 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1558742 8191853 METDI1695 Methylobacterium extorquens DM4 hypothetical protein YP_003067270.1 1558203 D 661410 CDS YP_003067271.1 254560176 8191854 complement(1558825..1559607) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; transposase of ISMdi18, IS1595 family 1559607 8191854 METDI1696 Methylobacterium extorquens DM4 transposase of ISMdi18, IS1595 family YP_003067271.1 1558825 R 661410 CDS YP_003067272.1 254560177 8191855 1560162..1561001 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative formate/nitrate transporter 1561001 8191855 METDI1697 Methylobacterium extorquens DM4 putative formate/nitrate transporter YP_003067272.1 1560162 D 661410 CDS YP_003067273.1 254560178 8191856 1561069..1562784 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative dual serine/threonine-protein kinase/phosphatase 1562784 8191856 METDI1698 Methylobacterium extorquens DM4 putative dual serine/threonine-protein kinase/phosphatase YP_003067273.1 1561069 D 661410 CDS YP_003067274.1 254560179 8191857 complement(1563855..1565873) 1 NC_012988.1 [UDP-forming]; Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative Cellulose synthase catalytic subunit 1565873 8191857 METDI1699 Methylobacterium extorquens DM4 putative Cellulose synthase catalytic subunit YP_003067274.1 1563855 R 661410 CDS YP_003067275.1 254560180 8191858 complement(1565855..1567021) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type t : transporter; Multidrug resistance efflux pump 1567021 8191858 METDI1700 Methylobacterium extorquens DM4 Multidrug resistance efflux pump YP_003067275.1 1565855 R 661410 CDS YP_003067276.1 254560181 8191859 complement(1568185..1568574) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1568574 8191859 METDI1701 Methylobacterium extorquens DM4 hypothetical protein YP_003067276.1 1568185 R 661410 CDS YP_003067277.1 254560182 8191860 1568663..1568908 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1568908 8191860 METDI1702 Methylobacterium extorquens DM4 hypothetical protein YP_003067277.1 1568663 D 661410 CDS YP_003067278.1 254560183 8191861 1568869..1569255 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1569255 8191861 METDI1703 Methylobacterium extorquens DM4 hypothetical protein YP_003067278.1 1568869 D 661410 CDS YP_003067279.1 254560184 8191864 complement(1570387..1571139) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; transposase of ISMdi3, IS3 family (ORF 2) 1571139 8191864 METDI1706 Methylobacterium extorquens DM4 transposase of ISMdi3, IS3 family (ORF 2) YP_003067279.1 1570387 R 661410 CDS YP_003067280.1 254560185 8191865 complement(1571247..1571528) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; transposase of ISMdi3, IS3 family (ORF 1) 1571528 8191865 METDI1707 Methylobacterium extorquens DM4 transposase of ISMdi3, IS3 family (ORF 1) YP_003067280.1 1571247 R 661410 CDS YP_003067281.1 254560186 8191866 1571607..1572410 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1572410 8191866 METDI1708 Methylobacterium extorquens DM4 hypothetical protein YP_003067281.1 1571607 D 661410 CDS YP_003067282.1 254560187 8191867 1572427..1572921 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1572921 8191867 METDI1709 Methylobacterium extorquens DM4 hypothetical protein YP_003067282.1 1572427 D 661410 CDS YP_003067283.1 254560188 8191868 complement(1572935..1573120) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1573120 8191868 METDI1710 Methylobacterium extorquens DM4 hypothetical protein YP_003067283.1 1572935 R 661410 CDS YP_003067284.1 254560189 8191869 complement(1573298..1574140) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1574140 8191869 METDI1711 Methylobacterium extorquens DM4 hypothetical protein YP_003067284.1 1573298 R 661410 CDS YP_003067285.1 254560190 8191870 complement(1574182..1577373) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type t : transporter; multidrug transport protein, acriflavin resistance protein F (RND family) 1577373 acrF 8191870 acrF Methylobacterium extorquens DM4 multidrug transport protein, acriflavin resistance protein F (RND family) YP_003067285.1 1574182 R 661410 CDS YP_003067286.1 254560191 8195055 complement(1577379..1578503) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative RND efflux transporter, membrane fusion protein subunit 1578503 8195055 METDI1713 Methylobacterium extorquens DM4 putative RND efflux transporter, membrane fusion protein subunit YP_003067286.1 1577379 R 661410 CDS YP_003067287.1 254560192 8191871 complement(1578760..1579014) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1579014 8191871 METDI1714 Methylobacterium extorquens DM4 hypothetical protein YP_003067287.1 1578760 R 661410 CDS YP_003067288.1 254560193 8191872 complement(1578962..1579411) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1579411 8191872 METDI1715 Methylobacterium extorquens DM4 hypothetical protein YP_003067288.1 1578962 R 661410 CDS YP_003067289.1 254560194 8191873 complement(1579415..1579840) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 1579840 8191873 METDI1716 Methylobacterium extorquens DM4 hypothetical protein YP_003067289.1 1579415 R 661410 CDS YP_003067290.1 254560195 8191874 1580260..1582200 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type t : transporter; Heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase:Heavy metal translocating P-type ATPase 1582200 8191874 METDI1717 Methylobacterium extorquens DM4 Heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase:Heavy metal translocating P-type ATPase YP_003067290.1 1580260 D 661410 CDS YP_003067291.1 254560196 8191875 complement(1582308..1582631) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 12151239, 12426355, 1840615; Product type r : regulator; transcriptional regulator, ArsR family 1582631 8191875 METDI1718 Methylobacterium extorquens DM4 transcriptional regulator, ArsR family YP_003067291.1 1582308 R 661410 CDS YP_003067292.1 254560197 8191876 complement(1583060..1584040) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type t : transporter; nitrate transport system ATP-binding protein 1584040 nrtC 8191876 nrtC Methylobacterium extorquens DM4 nitrate transport system ATP-binding protein YP_003067292.1 1583060 R 661410 CDS YP_003067293.1 254560198 8195783 complement(1584049..1584903) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type t : transporter; nitrate transport system permease protein 1584903 nrtB 8195783 nrtB Methylobacterium extorquens DM4 nitrate transport system permease protein YP_003067293.1 1584049 R 661410 CDS YP_003067294.1 254560199 8195781 complement(1584893..1586254) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type t : transporter; nitrate ABC transporter component precursor (substrate-binding protein) (tat pathway signal) 1586254 nrtA 8195781 nrtA Methylobacterium extorquens DM4 nitrate ABC transporter component precursor (substrate-binding protein) (tat pathway signal) YP_003067294.1 1584893 R 661410 CDS YP_003067295.1 254560200 8195779 complement(1586420..1587754) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; FAD-dependent pyridine nucleotide-disulphide oxidoreductase:Rubredoxin-type Fe(Cys)4 protein 1587754 8195779 METDI1722 Methylobacterium extorquens DM4 FAD-dependent pyridine nucleotide-disulphide oxidoreductase:Rubredoxin-type Fe(Cys)4 protein YP_003067295.1 1586420 R 661410 CDS YP_003067296.1 254560201 8191877 complement(1587751..1588944) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative acyl-CoA dehydrogenase 1588944 8191877 METDI1723 Methylobacterium extorquens DM4 putative acyl-CoA dehydrogenase YP_003067296.1 1587751 R 661410 CDS YP_003067297.1 254560202 8191878 complement(1589005..1589556) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; OsmC family protein (osmotically induced proteins) 1589556 8191878 METDI1724 Methylobacterium extorquens DM4 OsmC family protein (osmotically induced proteins) YP_003067297.1 1589005 R 661410 CDS YP_003067298.1 254560203 8191879 complement(1589769..1591373) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 2450865, 2840552; Product type pr : putative regulator; putative two-component sigma-54 specific transcriptional regulator, Fis subfamily; with N-terminal response receiver, GAF and ATPase domains 1591373 8191879 METDI1725 Methylobacterium extorquens DM4 putative two-component sigma-54 specific transcriptional regulator, Fis subfamily; with N-terminal response receiver, GAF and ATPase domains YP_003067298.1 1589769 R 661410 CDS YP_003067299.1 254560204 8191880 complement(1591743..1592717) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative bifunctional protein; N-terminal amidase, C-terminal transcriptional regulator, AraC family 1592717 8191880 METDI1726 Methylobacterium extorquens DM4 putative bifunctional protein; N-terminal amidase, C-terminal transcriptional regulator, AraC family YP_003067299.1 1591743 R 661410 CDS YP_003067300.1 254560205 8191881 1592810..1593514 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 12244065; Product type e : enzyme; isonitrile hydratase, ThiJ/PfpI family protein 1593514 inh 8191881 inh Methylobacterium extorquens DM4 isonitrile hydratase, ThiJ/PfpI family protein YP_003067300.1 1592810 D 661410 CDS YP_003067301.1 254560206 8195600 complement(1593589..1595157) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative sodium:solute symporter 1595157 8195600 METDI1728 Methylobacterium extorquens DM4 putative sodium:solute symporter YP_003067301.1 1593589 R 661410 CDS YP_003067302.1 254560207 8191882 complement(1595168..1595389) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1595389 8191882 METDI1729 Methylobacterium extorquens DM4 hypothetical protein YP_003067302.1 1595168 R 661410 CDS YP_003067303.1 254560208 8191883 complement(1595573..1596682) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative nitrilase 1596682 8191883 METDI1730 Methylobacterium extorquens DM4 putative nitrilase YP_003067303.1 1595573 R 661410 CDS YP_003067304.1 254560209 8191884 complement(1596785..1597681) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type r : regulator; transcriptional regulator, LysR family 1597681 8191884 METDI1731 Methylobacterium extorquens DM4 transcriptional regulator, LysR family YP_003067304.1 1596785 R 661410 CDS YP_003067305.1 254560210 8191885 1598497..1599051 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type f : factor; RNA polymerase sigma factor 1599051 8191885 METDI1734 Methylobacterium extorquens DM4 RNA polymerase sigma factor YP_003067305.1 1598497 D 661410 CDS YP_003067306.1 254560211 8191886 complement(1599537..1599833) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type r : regulator; Transcriptional regulator, Cro/CI family 1599833 8191886 METDI1736 Methylobacterium extorquens DM4 Transcriptional regulator, Cro/CI family YP_003067306.1 1599537 R 661410 CDS YP_003067307.1 254560212 8191887 1600193..1601956 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type t : transporter; type I secretion system ATPase 1601956 8191887 METDI1737 Methylobacterium extorquens DM4 type I secretion system ATPase YP_003067307.1 1600193 D 661410 CDS YP_003067308.1 254560213 8191888 1601966..1603342 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type t : transporter; type I secretion membrane fusion protein, HlyD family 1603342 8191888 METDI1738 Methylobacterium extorquens DM4 type I secretion membrane fusion protein, HlyD family YP_003067308.1 1601966 D 661410 CDS YP_003067309.1 254560214 8191889 1603421..1607839 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1607839 8191889 METDI1739 Methylobacterium extorquens DM4 hypothetical protein YP_003067309.1 1603421 D 661410 CDS YP_003067310.1 254560215 8191890 complement(1607978..1609933) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type e : enzyme; putative Cellulose synthase (UDP-forming) 1609933 8191890 METDI1740 Methylobacterium extorquens DM4 putative Cellulose synthase (UDP-forming) YP_003067310.1 1607978 R 661410 CDS YP_003067311.1 254560216 8191891 complement(1609933..1611108) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1611108 8191891 METDI1741 Methylobacterium extorquens DM4 hypothetical protein YP_003067311.1 1609933 R 661410 CDS YP_003067312.1 254560217 8191892 complement(1611144..1612898) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1612898 8191892 METDI1742 Methylobacterium extorquens DM4 hypothetical protein YP_003067312.1 1611144 R 661410 CDS YP_003067313.1 254560218 8191893 complement(1614054..1614854) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 10913158; Product type t : transporter; ABC transporter, ATPase 1614854 8191893 METDI1743 Methylobacterium extorquens DM4 ABC transporter, ATPase YP_003067313.1 1614054 R 661410 CDS YP_003067314.1 254560219 8191894 complement(1614848..1615846) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type t : transporter; ABC transporter, permease 1615846 8191894 METDI1744 Methylobacterium extorquens DM4 ABC transporter, permease YP_003067314.1 1614848 R 661410 CDS YP_003067315.1 254560220 8191895 complement(1615856..1616941) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type t : transporter; ABC transporter, periplasmic protein 1616941 8191895 METDI1745 Methylobacterium extorquens DM4 ABC transporter, periplasmic protein YP_003067315.1 1615856 R 661410 CDS YP_003067316.1 254560221 8191896 1617479..1618624 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; Acyl-CoA dehydrogenase 1618624 8191896 METDI1746 Methylobacterium extorquens DM4 Acyl-CoA dehydrogenase YP_003067316.1 1617479 D 661410 CDS YP_003067317.1 254560222 8191897 1618643..1619740 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10506196; Product type pe : putative enzyme; putative alkanesulfonate monooxygenase 1619740 8191897 METDI1747 Methylobacterium extorquens DM4 putative alkanesulfonate monooxygenase YP_003067317.1 1618643 D 661410 CDS YP_003067318.1 254560223 8191898 1619740..1620681 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type t : transporter; ABC transporter, substrate-binding protein, aliphatic sulphonates 1620681 ssuA 8191898 ssuA Methylobacterium extorquens DM4 ABC transporter, substrate-binding protein, aliphatic sulphonates YP_003067318.1 1619740 D 661410 CDS YP_003067319.1 254560224 8196149 1620708..1621250 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative mannose-6-phosphate isomerase 1621250 8196149 METDI1749 Methylobacterium extorquens DM4 putative mannose-6-phosphate isomerase YP_003067319.1 1620708 D 661410 CDS YP_003067320.1 254560225 8191899 1621900..1622103 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1622103 8191899 METDI1751 Methylobacterium extorquens DM4 hypothetical protein YP_003067320.1 1621900 D 661410 CDS YP_003067321.1 254560226 8191900 1622189..1623034 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 10617639, 3309158; Product type e : enzyme; serine acetyltransferase 1623034 cysE-2 8191900 cysE-2 Methylobacterium extorquens DM4 serine acetyltransferase YP_003067321.1 1622189 D 661410 CDS YP_003067322.1 254560227 8195252 1623455..1624846 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 11325927, 11567001, 12488450, 16788203, 16926146; Product type e : enzyme; eshA 1624846 eshA 8195252 eshA Methylobacterium extorquens DM4 eshA YP_003067322.1 1623455 D 661410 CDS YP_003067323.1 254560228 8195333 1624833..1626857 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative cysteine desulfurase 1626857 8195333 METDI1754 Methylobacterium extorquens DM4 putative cysteine desulfurase YP_003067323.1 1624833 D 661410 CDS YP_003067324.1 254560229 8191901 complement(1626932..1627516) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1627516 8191901 METDI1755 Methylobacterium extorquens DM4 hypothetical protein YP_003067324.1 1626932 R 661410 CDS YP_003067325.1 254560230 8191903 1629180..1630157 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative Thioredoxin reductase 1630157 8191903 METDI1759 Methylobacterium extorquens DM4 putative Thioredoxin reductase YP_003067325.1 1629180 D 661410 CDS YP_003067326.1 254560231 8191904 1630385..1631254 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; putative outer-membrane immunogenic protein precursor 1631254 8191904 METDI1760 Methylobacterium extorquens DM4 putative outer-membrane immunogenic protein precursor YP_003067326.1 1630385 D 661410 CDS YP_003067327.1 254560232 8191905 1631643..1631894 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1631894 8191905 METDI1761 Methylobacterium extorquens DM4 hypothetical protein YP_003067327.1 1631643 D 661410 CDS YP_003067328.1 254560233 8191906 1631906..1632319 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1632319 8191906 METDI1762 Methylobacterium extorquens DM4 hypothetical protein YP_003067328.1 1631906 D 661410 CDS YP_003067329.1 254560234 8191907 1633662..1633871 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 10483731, 10618253; Product type f : factor; cold shock DNA binding protein CspA 1633871 cspA 8191907 cspA Methylobacterium extorquens DM4 cold shock DNA binding protein CspA YP_003067329.1 1633662 D 661410 CDS YP_003067330.1 254560235 8195223 1634079..1634324 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1634324 8195223 METDI1764 Methylobacterium extorquens DM4 hypothetical protein YP_003067330.1 1634079 D 661410 CDS YP_003067331.1 254560236 8191908 complement(1634547..1634879) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1634879 8191908 METDI1765 Methylobacterium extorquens DM4 hypothetical protein YP_003067331.1 1634547 R 661410 CDS YP_003067332.1 254560237 8191909 1635234..1637192 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1637192 8191909 METDI1766 Methylobacterium extorquens DM4 hypothetical protein YP_003067332.1 1635234 D 661410 CDS YP_003067333.1 254560238 8191910 complement(1637364..1638095) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1638095 8191910 METDI1767 Methylobacterium extorquens DM4 hypothetical protein YP_003067333.1 1637364 R 661410 CDS YP_003067334.1 254560239 8191911 complement(1638507..1641503) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative histidine kinase of the HWE family 1641503 8191911 METDI1768 Methylobacterium extorquens DM4 putative histidine kinase of the HWE family YP_003067334.1 1638507 R 661410 CDS YP_003067335.1 254560240 8191912 complement(1641738..1642412) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1642412 8191912 METDI1769 Methylobacterium extorquens DM4 hypothetical protein YP_003067335.1 1641738 R 661410 CDS YP_003067336.1 254560241 8191913 1642850..1644817 1 NC_012988.1 in group A Streptococci this protein was found to cross react with anti myosin antibodies and may play a role in rheumatic fever; myosin-cross-reactive antigen 1644817 8191913 METDI1770 Methylobacterium extorquens DM4 myosin-cross-reactive antigen YP_003067336.1 1642850 D 661410 CDS YP_003067337.1 254560242 8191914 1645080..1646123 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1646123 8191914 METDI1771 Methylobacterium extorquens DM4 hypothetical protein YP_003067337.1 1645080 D 661410 CDS YP_003067338.1 254560243 8191915 1646407..1646871 1 NC_012988.1 involved in the assembly of the urease metallocenter; possible nickel donor; urease accessory protein UreE 1646871 ureE 8191915 ureE Methylobacterium extorquens DM4 urease accessory protein UreE YP_003067338.1 1646407 D 661410 CDS YP_003067339.1 254560244 8191916 1646876..1647556 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type f : factor; putative urease accessory protein UreF 1647556 8191916 METDI1774 Methylobacterium extorquens DM4 putative urease accessory protein UreF YP_003067339.1 1646876 D 661410 CDS YP_003067340.1 254560245 8191917 1647570..1648265 1 NC_012988.1 ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 ureC (alpha) and 3 ureAB (gamma/beta) subunits; bifunctional urease subunit gamma/beta 1648265 ureAB 8191917 ureAB Methylobacterium extorquens DM4 bifunctional urease subunit gamma/beta YP_003067340.1 1647570 D 661410 CDS YP_003067341.1 254560246 8196309 1648281..1649993 1 NC_012988.1 ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 ureC (alpha) and 3 ureAB (gamma/beta) subunits; urease subunit alpha 1649993 ureC 8196309 ureC Methylobacterium extorquens DM4 urease subunit alpha YP_003067341.1 1648281 D 661410 CDS YP_003067342.1 254560247 8196313 1649990..1650634 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 8045421; Product type e : enzyme; urease accessory protein UreG 1650634 ureG 8196313 ureG Methylobacterium extorquens DM4 urease accessory protein UreG YP_003067342.1 1649990 D 661410 CDS YP_003067343.1 254560248 8196325 1650634..1651518 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 7813887; Product type f : factor; putative urease accessory protein UreD 1651518 8196325 METDI1778 Methylobacterium extorquens DM4 putative urease accessory protein UreD YP_003067343.1 1650634 D 661410 CDS YP_003067344.1 254560249 8191918 1651708..1652949 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 9245819, 9492267; Product type f : factor; short-chain amide-urea binding porin 1652949 fmdD 8191918 fmdD Methylobacterium extorquens DM4 short-chain amide-urea binding porin YP_003067344.1 1651708 D 661410 CDS YP_003067345.1 254560250 8195433 complement(1652965..1654161) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1654161 8195433 METDI1780 Methylobacterium extorquens DM4 hypothetical protein YP_003067345.1 1652965 R 661410 CDS YP_003067346.1 254560251 8191919 complement(1654161..1656362) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type prc : putative receptor; putative TonB-dependent porin receptor 1656362 8191919 METDI1781 Methylobacterium extorquens DM4 putative TonB-dependent porin receptor YP_003067346.1 1654161 R 661410 CDS YP_003067347.1 254560252 8195033 1657112..1658302 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1658302 8195033 METDI1782 Methylobacterium extorquens DM4 hypothetical protein YP_003067347.1 1657112 D 661410 CDS YP_003067348.1 254560253 8191921 complement(1658426..1658794) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1658794 8191921 METDI1783 Methylobacterium extorquens DM4 hypothetical protein YP_003067348.1 1658426 R 661410 CDS YP_003067349.1 254560254 8191922 complement(1658827..1659270) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1659270 8191922 METDI1784 Methylobacterium extorquens DM4 hypothetical protein YP_003067349.1 1658827 R 661410 CDS YP_003067350.1 254560255 8191923 1659336..1659512 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 1659512 8191923 METDI1785 Methylobacterium extorquens DM4 hypothetical protein YP_003067350.1 1659336 D 661410 CDS YP_003067351.1 254560256 8191924 1659537..1659986 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1659986 8191924 METDI1786 Methylobacterium extorquens DM4 hypothetical protein YP_003067351.1 1659537 D 661410 CDS YP_003067352.1 254560257 8191925 1660087..1661337 1 NC_012988.1 catalyzes the formation of oxalyl-CoA from oxalate and Formyl-CoA; formyl-coenzyme A transferase 1661337 frc 8191925 frc Methylobacterium extorquens DM4 formyl-coenzyme A transferase YP_003067352.1 1660087 D 661410 CDS YP_003067353.1 254560258 8195442 complement(1661577..1662296) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; Phospholipase/Carboxylesterase 1662296 8195442 METDI1788 Methylobacterium extorquens DM4 Phospholipase/Carboxylesterase YP_003067353.1 1661577 R 661410 CDS YP_003067354.1 254560259 8191926 complement(1662560..1664311) 1 NC_012988.1 catalyzes the formation of formyl-CoA from oxalyl-CoA; putative oxalyl-CoA decarboxylase 1664311 8191926 METDI1789 Methylobacterium extorquens DM4 putative oxalyl-CoA decarboxylase YP_003067354.1 1662560 R 661410 CDS YP_003067355.1 254560260 8191927 complement(1664788..1667079) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative Galactose oxidase 1667079 8191927 METDI1790 Methylobacterium extorquens DM4 putative Galactose oxidase YP_003067355.1 1664788 R 661410 CDS YP_003067356.1 254560261 8191928 complement(1667432..1668757) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type t : transporter; oxalate/formate antiporter 1668757 oxlT 8191928 oxlT Methylobacterium extorquens DM4 oxalate/formate antiporter YP_003067356.1 1667432 R 661410 CDS YP_003067357.1 254560262 8195817 complement(1669022..1670278) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type t : transporter; oxalate/formate antiporter 1670278 oxlT 8195817 oxlT Methylobacterium extorquens DM4 oxalate/formate antiporter YP_003067357.1 1669022 R 661410 CDS YP_003067358.1 254560263 8195818 complement(1670783..1670956) 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 1670956 8195818 METDI1793 Methylobacterium extorquens DM4 hypothetical protein YP_003067358.1 1670783 R 661410 CDS YP_003067359.1 254560264 8191929 1670873..1671313 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1671313 8191929 METDI1794 Methylobacterium extorquens DM4 hypothetical protein YP_003067359.1 1670873 D 661410 CDS YP_003067360.1 254560265 8191930 1671480..1671761 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1671761 8191930 METDI1795 Methylobacterium extorquens DM4 hypothetical protein YP_003067360.1 1671480 D 661410 CDS YP_003067361.1 254560266 8191931 1671784..1673640 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1673640 8191931 METDI1796 Methylobacterium extorquens DM4 hypothetical protein YP_003067361.1 1671784 D 661410 CDS YP_003067362.1 254560267 8191932 1673653..1673838 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 1673838 8191932 METDI1797 Methylobacterium extorquens DM4 hypothetical protein YP_003067362.1 1673653 D 661410 CDS YP_003067363.1 254560268 8191933 1673860..1674027 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 1674027 8191933 METDI1798 Methylobacterium extorquens DM4 hypothetical protein YP_003067363.1 1673860 D 661410 CDS YP_003067364.1 254560269 8191934 complement(1674009..1674236) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1674236 8191934 METDI1799 Methylobacterium extorquens DM4 hypothetical protein YP_003067364.1 1674009 R 661410 CDS YP_003067365.1 254560270 8191935 complement(1674375..1675664) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 12844490; Product type e : enzyme; formyl-CoA transferase, NAD(P)-binding 1675664 frc 8191935 frc Methylobacterium extorquens DM4 formyl-CoA transferase, NAD(P)-binding YP_003067365.1 1674375 R 661410 CDS YP_003067366.1 254560271 8195443 1676085..1676768 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type r : regulator; transcriptional regulator, GntR family 1676768 8195443 METDI1801 Methylobacterium extorquens DM4 transcriptional regulator, GntR family YP_003067366.1 1676085 D 661410 CDS YP_003067367.1 254560272 8191936 complement(1676900..1678000) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative GTPase, putative cobalamin biosynthesis protein (CobW homolog) 1678000 8191936 METDI1802 Methylobacterium extorquens DM4 putative GTPase, putative cobalamin biosynthesis protein (CobW homolog) YP_003067367.1 1676900 R 661410 CDS YP_003067368.1 254560273 8191937 complement(1678132..1679637) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; serine-type D-alanyl-D-alanine carboxypeptidase precursor 1679637 8191937 METDI1803 Methylobacterium extorquens DM4 serine-type D-alanyl-D-alanine carboxypeptidase precursor YP_003067368.1 1678132 R 661410 CDS YP_003067369.1 254560274 8191938 1679909..1680547 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1680547 8191938 METDI1804 Methylobacterium extorquens DM4 hypothetical protein YP_003067369.1 1679909 D 661410 CDS YP_003067370.1 254560275 8191939 1680711..1681148 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1681148 8191939 METDI1805 Methylobacterium extorquens DM4 hypothetical protein YP_003067370.1 1680711 D 661410 CDS YP_003067371.1 254560276 8191940 1681241..1681525 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1681525 8191940 METDI1806 Methylobacterium extorquens DM4 hypothetical protein YP_003067371.1 1681241 D 661410 CDS YP_003067372.1 254560277 8191941 complement(1681619..1682860) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative hydroxylase 1682860 8191941 METDI1807 Methylobacterium extorquens DM4 putative hydroxylase YP_003067372.1 1681619 R 661410 CDS YP_003067373.1 254560278 8191942 complement(1683146..1683583) 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 1683583 8191942 METDI1808 Methylobacterium extorquens DM4 hypothetical protein YP_003067373.1 1683146 R 661410 CDS YP_003067374.1 254560279 8191943 1683692..1684048 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type e : enzyme; putative 6-pyruvol tetrahydrobiopterin synthase 1684048 ptpS 8191943 ptpS Methylobacterium extorquens DM4 putative 6-pyruvol tetrahydrobiopterin synthase YP_003067374.1 1683692 D 661410 CDS YP_003067375.1 254560280 8195916 1684051..1684782 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type pr : putative regulator; putative regulator, ATP-binding 1684782 exsB 8195916 exsB Methylobacterium extorquens DM4 putative regulator, ATP-binding YP_003067375.1 1684051 D 661410 CDS YP_003067376.1 254560281 8195340 1684793..1685530 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative LmbE-like protein 1685530 8195340 METDI1811 Methylobacterium extorquens DM4 putative LmbE-like protein YP_003067376.1 1684793 D 661410 CDS YP_003067377.1 254560282 8191944 1685621..1686472 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15294902; Product type pe : putative enzyme; putative glycosyl transferase 1686472 8191944 METDI1812 Methylobacterium extorquens DM4 putative glycosyl transferase YP_003067377.1 1685621 D 661410 CDS YP_003067378.1 254560283 8191945 1686866..1687048 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1687048 8191945 METDI1813 Methylobacterium extorquens DM4 hypothetical protein YP_003067378.1 1686866 D 661410 CDS YP_003067379.1 254560284 8191946 1687049..1687276 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1687276 8191946 METDI1814 Methylobacterium extorquens DM4 hypothetical protein YP_003067379.1 1687049 D 661410 CDS YP_003067380.1 254560285 8191947 1687339..1687632 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1687632 8191947 METDI1815 Methylobacterium extorquens DM4 hypothetical protein YP_003067380.1 1687339 D 661410 CDS YP_003067381.1 254560286 8191948 complement(1687781..1688830) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative glycosyl transferase; putative UDP-N-acetylglucosamine, LPS N-acetylglucosamine transferase 1688830 8191948 METDI1816 Methylobacterium extorquens DM4 putative glycosyl transferase; putative UDP-N-acetylglucosamine, LPS N-acetylglucosamine transferase YP_003067381.1 1687781 R 661410 CDS YP_003067382.1 254560287 8191949 complement(1688891..1689979) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12213785; Product type pe : putative enzyme; putative glycosyl transferase 1689979 8191949 METDI1817 Methylobacterium extorquens DM4 putative glycosyl transferase YP_003067382.1 1688891 R 661410 CDS YP_003067383.1 254560288 8191950 complement(1689984..1691078) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11583114, 12788726, 15838019, 16934238; Product type pe : putative enzyme; putative glycosyl transferase 1691078 8191950 METDI1818 Methylobacterium extorquens DM4 putative glycosyl transferase YP_003067383.1 1689984 R 661410 CDS YP_003067384.1 254560289 8191951 complement(1691187..1691366) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1691366 8191951 METDI1819 Methylobacterium extorquens DM4 hypothetical protein YP_003067384.1 1691187 R 661410 CDS YP_003067385.1 254560290 8191952 1691307..1691513 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 1691513 8191952 METDI1820 Methylobacterium extorquens DM4 hypothetical protein YP_003067385.1 1691307 D 661410 CDS YP_003067386.1 254560291 8191953 complement(1691593..1691904) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative Phosphoryl transfer system, HPr 1691904 8191953 METDI1821 Methylobacterium extorquens DM4 putative Phosphoryl transfer system, HPr YP_003067386.1 1691593 R 661410 CDS YP_003067387.1 254560292 8191954 complement(1692050..1692442) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative PTS system subfamily mannose/fructose-specific IIA component 1692442 8191954 METDI1822 Methylobacterium extorquens DM4 putative PTS system subfamily mannose/fructose-specific IIA component YP_003067387.1 1692050 R 661410 CDS YP_003067388.1 254560293 8191955 complement(1692577..1693092) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative PTS system Hpr Kinase 1693092 8191955 METDI1823 Methylobacterium extorquens DM4 putative PTS system Hpr Kinase YP_003067388.1 1692577 R 661410 CDS YP_003067389.1 254560294 8191956 complement(1693089..1694939) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 11481430, 11743193, 11743194, 7559334, 8407839, 9422587, 9701808; Product type r : regulator; integral membrane sensor signal transduction histidine kinase 1694939 8191956 METDI1824 Methylobacterium extorquens DM4 integral membrane sensor signal transduction histidine kinase YP_003067389.1 1693089 R 661410 CDS YP_003067390.1 254560295 8191957 complement(1694968..1695681) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 7559334, 8407839; Product type r : regulator; Two-component response regulator ChvI 1695681 chvI 8191957 chvI Methylobacterium extorquens DM4 Two-component response regulator ChvI YP_003067390.1 1694968 R 661410 CDS YP_003067391.1 254560296 8195167 1696081..1696896 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1696896 8195167 METDI1826 Methylobacterium extorquens DM4 hypothetical protein YP_003067391.1 1696081 D 661410 CDS YP_003067392.1 254560297 8191958 1697057..1698862 1 NC_012988.1 binds to the ribosome on the universally-conserved alpha-sarcin loop; GTP-binding protein LepA 1698862 lepA 8191958 lepA Methylobacterium extorquens DM4 GTP-binding protein LepA YP_003067392.1 1697057 D 661410 CDS YP_003067393.1 254560298 8195627 1699302..1700555 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative heavy metal efflux pump, HlyD family secretion protein 1700555 8195627 METDI1828 Methylobacterium extorquens DM4 putative heavy metal efflux pump, HlyD family secretion protein YP_003067393.1 1699302 D 661410 CDS YP_003067394.1 254560299 8191959 1700647..1703817 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type t : transporter; Heavy metal efflux pump CzcA 1703817 czcA 8191959 czcA Methylobacterium extorquens DM4 Heavy metal efflux pump CzcA YP_003067394.1 1700647 D 661410 CDS YP_003067395.1 254560300 8195268 complement(1704273..1705346) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; PubMedId : 1823284; hypothetical protein 1705346 8195268 METDI1830 Methylobacterium extorquens DM4 hypothetical protein YP_003067395.1 1704273 R 661410 CDS YP_003067396.1 254560301 8191960 complement(1705393..1708473) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12461003; Product type pe : putative enzyme; putative bifunctional N-terminal transglycosylase/C-terminal transpeptidase 1708473 8191960 METDI1831 Methylobacterium extorquens DM4 putative bifunctional N-terminal transglycosylase/C-terminal transpeptidase YP_003067396.1 1705393 R 661410 CDS YP_003067397.1 254560302 8191961 complement(1708664..1709863) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1709863 8191961 METDI1832 Methylobacterium extorquens DM4 hypothetical protein YP_003067397.1 1708664 R 661410 CDS YP_003067398.1 254560303 8191962 complement(1710047..1711246) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1711246 8191962 METDI1833 Methylobacterium extorquens DM4 hypothetical protein YP_003067398.1 1710047 R 661410 CDS YP_003067399.1 254560304 8191963 1711450..1711866 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative flagellar FlbT family protein 1711866 8191963 METDI1834 Methylobacterium extorquens DM4 putative flagellar FlbT family protein YP_003067399.1 1711450 D 661410 CDS YP_003067400.1 254560305 8191964 complement(1711963..1712178) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1712178 8191964 METDI1835 Methylobacterium extorquens DM4 hypothetical protein YP_003067400.1 1711963 R 661410 CDS YP_003067401.1 254560306 8191965 complement(1712273..1713436) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; Acyltransferase 3 family 1713436 8191965 METDI1836 Methylobacterium extorquens DM4 Acyltransferase 3 family YP_003067401.1 1712273 R 661410 CDS YP_003067402.1 254560307 8191966 1713740..1715125 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; Metal-dependent phosphohydrolase, HD subdomain 1715125 8191966 METDI1837 Methylobacterium extorquens DM4 Metal-dependent phosphohydrolase, HD subdomain YP_003067402.1 1713740 D 661410 CDS YP_003067403.1 254560308 8191967 complement(1715216..1715593) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1715593 8191967 METDI1838 Methylobacterium extorquens DM4 hypothetical protein YP_003067403.1 1715216 R 661410 CDS YP_003067404.1 254560309 8191968 1715770..1716198 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1716198 8191968 METDI1839 Methylobacterium extorquens DM4 hypothetical protein YP_003067404.1 1715770 D 661410 CDS YP_003067405.1 254560310 8191969 complement(1716321..1717073) 1 NC_012988.1 catalyzes the removal of N-terminal amino acids from peptides and arylamides; generally Co(II) however activity has been shown for some methionine aminopeptidases with Zn, Fe, or Mnin Bacillus subtilis the protein in this cluster is considered non-essential; methionine aminopeptidase 1717073 map 8191969 map Methylobacterium extorquens DM4 methionine aminopeptidase YP_003067405.1 1716321 R 661410 CDS YP_003067406.1 254560311 8195660 1717682..1718341 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1718341 8195660 METDI1841 Methylobacterium extorquens DM4 hypothetical protein YP_003067406.1 1717682 D 661410 CDS YP_003067407.1 254560312 8191970 complement(1718376..1719182) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative CoxB 1719182 8191970 METDI1842 Methylobacterium extorquens DM4 putative CoxB YP_003067407.1 1718376 R 661410 CDS YP_003067408.1 254560313 8191971 complement(1719668..1720525) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1720525 8191971 METDI1843 Methylobacterium extorquens DM4 hypothetical protein YP_003067408.1 1719668 R 661410 CDS YP_003067409.1 254560314 8191972 complement(1720525..1721880) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 2134335, 2793824; Product type r : regulator; two-component DctB-like sigma-54 specific transcriptional regulator, Fis subfamily; with N-terminal response regulator receiver and ATPase domains 1721880 8191972 METDI1844 Methylobacterium extorquens DM4 two-component DctB-like sigma-54 specific transcriptional regulator, Fis subfamily; with N-terminal response regulator receiver and ATPase domains YP_003067409.1 1720525 R 661410 CDS YP_003067410.1 254560315 8191973 complement(1721870..1723750) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type prc : putative receptor; putative sensor histidine kinase precursor, putative transcriptional regulator of C4 dicarboxylate transporter 1723750 8191973 METDI1845 Methylobacterium extorquens DM4 putative sensor histidine kinase precursor, putative transcriptional regulator of C4 dicarboxylate transporter YP_003067410.1 1721870 R 661410 CDS YP_003067411.1 254560316 8191974 complement(1724014..1724895) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 9401024, 96404792; Product type t : transporter; taurine transport protein (ABC superfamily, atp_bind) 1724895 tauB 8191974 tauB Methylobacterium extorquens DM4 taurine transport protein (ABC superfamily, atp_bind) YP_003067411.1 1724014 R 661410 CDS YP_003067412.1 254560317 8196182 complement(1724904..1725689) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type t : transporter; alkanesulfonate transporter subunit ; membrane component of ABC superfamily 1725689 ssuC 8196182 ssuC Methylobacterium extorquens DM4 alkanesulfonate transporter subunit ; membrane component of ABC superfamily YP_003067412.1 1724904 R 661410 CDS YP_003067413.1 254560318 8196159 complement(1725738..1726718) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type pf : putative factor; Extracellular solute-binding protein, family 3 precursor 1726718 8196159 METDI1848 Methylobacterium extorquens DM4 Extracellular solute-binding protein, family 3 precursor YP_003067413.1 1725738 R 661410 CDS YP_003067414.1 254560319 8191975 complement(1726982..1727710) 1 NC_012988.1 blocks the formation of polar Z-ring septums; septum formation inhibitor 1727710 minC 8191975 minC Methylobacterium extorquens DM4 septum formation inhibitor YP_003067414.1 1726982 R 661410 CDS YP_003067415.1 254560320 8195696 complement(1727837..1729105) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1729105 8195696 METDI1850 Methylobacterium extorquens DM4 hypothetical protein YP_003067415.1 1727837 R 661410 CDS YP_003067416.1 254560321 8191976 1729444..1731270 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 7783627, 9298646, 9622352, 9642082; Product type f : factor; GTP-binding elongation factor family protein with P-loop containing NTP hydrolase domain 1731270 typA 8191976 typA Methylobacterium extorquens DM4 GTP-binding elongation factor family protein with P-loop containing NTP hydrolase domain YP_003067416.1 1729444 D 661410 CDS YP_003067417.1 254560322 8196291 complement(1731413..1733101) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type prc : putative receptor; putative methyl-accepting chemotaxis sensory transducer 1733101 8196291 METDI1852 Methylobacterium extorquens DM4 putative methyl-accepting chemotaxis sensory transducer YP_003067417.1 1731413 R 661410 CDS YP_003067418.1 254560323 8191977 1733473..1734159 1 NC_012988.1 blocks the formation of polar Z-ring septums; septum formation inhibitor 1734159 minC 8191977 minC Methylobacterium extorquens DM4 septum formation inhibitor YP_003067418.1 1733473 D 661410 CDS YP_003067419.1 254560324 8195697 1734172..1734987 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 10096083, 11248256, 12519187, 90138951, 1836760, 1729224, 99248411; Product type e : enzyme; membrane ATPase of the MinC-MinD-MinE system 1734987 minD 8195697 minD Methylobacterium extorquens DM4 membrane ATPase of the MinC-MinD-MinE system YP_003067419.1 1734172 D 661410 CDS YP_003067420.1 254560325 8195698 1734984..1735271 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 12271122; Product type f : factor; cell division topological specificity factor 1735271 minE 8195698 minE Methylobacterium extorquens DM4 cell division topological specificity factor YP_003067420.1 1734984 D 661410 CDS YP_003067421.1 254560326 8195699 complement(1735547..1736926) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative cytochrome P450 family enzyme 1736926 8195699 METDI1856 Methylobacterium extorquens DM4 putative cytochrome P450 family enzyme YP_003067421.1 1735547 R 661410 CDS YP_003067422.1 254560327 8191978 1737181..1738074 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1738074 8191978 METDI1857 Methylobacterium extorquens DM4 hypothetical protein YP_003067422.1 1737181 D 661410 CDS YP_003067423.1 254560328 8191979 1738232..1740082 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative glycoside hydrolase 1740082 8191979 METDI1858 Methylobacterium extorquens DM4 putative glycoside hydrolase YP_003067423.1 1738232 D 661410 CDS YP_003067424.1 254560329 8191980 1740091..1741053 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative dehydrogenase protein 1741053 8191980 METDI1859 Methylobacterium extorquens DM4 putative dehydrogenase protein YP_003067424.1 1740091 D 661410 CDS YP_003067425.1 254560330 8191983 1742106..1743521 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative carbohydrate-selective porin 1743521 8191983 METDI1862 Methylobacterium extorquens DM4 putative carbohydrate-selective porin YP_003067425.1 1742106 D 661410 CDS YP_003067426.1 254560331 8191986 1744620..1746242 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative dipeptide transporter; periplasmic binding component of ABC superfamily (dppA-like) 1746242 8191986 METDI1865 Methylobacterium extorquens DM4 putative dipeptide transporter; periplasmic binding component of ABC superfamily (dppA-like) YP_003067426.1 1744620 D 661410 CDS YP_003067427.1 254560332 8191987 1746401..1747354 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative dipeptide transporter; membrane component of ABC superfamily (dppB-like) 1747354 8191987 METDI1866 Methylobacterium extorquens DM4 putative dipeptide transporter; membrane component of ABC superfamily (dppB-like) YP_003067427.1 1746401 D 661410 CDS YP_003067428.1 254560333 8191988 1747371..1748306 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative dipeptide transporter; membrane component of ABC superfamily (dppC-like) 1748306 8191988 METDI1867 Methylobacterium extorquens DM4 putative dipeptide transporter; membrane component of ABC superfamily (dppC-like) YP_003067428.1 1747371 D 661410 CDS YP_003067429.1 254560334 8191989 1748303..1749358 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 7536291; Product type t : transporter; dipeptide transporter; ATP-binding component of ABC superfamily 1749358 dppF 8191989 dppF Methylobacterium extorquens DM4 dipeptide transporter; ATP-binding component of ABC superfamily YP_003067429.1 1748303 D 661410 CDS YP_003067430.1 254560335 8195315 1749355..1750389 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 2821267, 3926486, 7536291; Product type t : transporter; dipeptide transporter; ATP-binding component of ABC superfamily 1750389 dppD 8195315 dppD Methylobacterium extorquens DM4 dipeptide transporter; ATP-binding component of ABC superfamily YP_003067430.1 1749355 D 661410 CDS YP_003067431.1 254560336 8195314 complement(1750750..1752249) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 10984043, 1339433; Product type e : enzyme; aldehyde dehydrogenase, putative malonate/methylmalonate semialdehyde dehydrogenase MmsA 1752249 8195314 METDI1870 Methylobacterium extorquens DM4 aldehyde dehydrogenase, putative malonate/methylmalonate semialdehyde dehydrogenase MmsA YP_003067431.1 1750750 R 661410 CDS YP_003067432.1 254560337 8191990 complement(1752315..1752791) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor; putative carbon monoxide dehydrogenase accessory protein CoxG 1752791 8191990 METDI1871 Methylobacterium extorquens DM4 putative carbon monoxide dehydrogenase accessory protein CoxG YP_003067432.1 1752315 R 661410 CDS YP_003067433.1 254560338 8191991 complement(1752821..1753525) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type t : transporter; ATP transport, ATPase 1753525 8191991 METDI1872 Methylobacterium extorquens DM4 ATP transport, ATPase YP_003067433.1 1752821 R 661410 CDS YP_003067434.1 254560339 8191992 complement(1753518..1754288) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type t : transporter; ABC transporter, ATPase 1754288 8191992 METDI1873 Methylobacterium extorquens DM4 ABC transporter, ATPase YP_003067434.1 1753518 R 661410 CDS YP_003067435.1 254560340 8191993 complement(1754285..1755298) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type t : transporter; ABC transporter, permease 1755298 8191993 METDI1874 Methylobacterium extorquens DM4 ABC transporter, permease YP_003067435.1 1754285 R 661410 CDS YP_003067436.1 254560341 8191994 complement(1755310..1756200) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type t : transporter; ABC transporter, permease 1756200 8191994 METDI1875 Methylobacterium extorquens DM4 ABC transporter, permease YP_003067436.1 1755310 R 661410 CDS YP_003067437.1 254560342 8191995 complement(1756218..1757495) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type t : transporter; ABC transporter, periplasmic protein (tat pathway signal) 1757495 8191995 METDI1876 Methylobacterium extorquens DM4 ABC transporter, periplasmic protein (tat pathway signal) YP_003067437.1 1756218 R 661410 CDS YP_003067438.1 254560343 8191996 complement(1757532..1759910) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; oxidoreductase, molybdopterin-binding subunit; putative carbon monoxide dehydrogenase, large subunit CoxL 1759910 8191996 METDI1877 Methylobacterium extorquens DM4 oxidoreductase, molybdopterin-binding subunit; putative carbon monoxide dehydrogenase, large subunit CoxL YP_003067438.1 1757532 R 661410 CDS YP_003067439.1 254560344 8191997 complement(1759907..1760410) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 10430865, 12475995; Product type e : enzyme; oxidoreductase, 2Fe-2S subunit; putative carbon monoxide dehydrogenase, small subunit CoxS 1760410 8191997 METDI1878 Methylobacterium extorquens DM4 oxidoreductase, 2Fe-2S subunit; putative carbon monoxide dehydrogenase, small subunit CoxS YP_003067439.1 1759907 R 661410 CDS YP_003067440.1 254560345 8191998 complement(1760407..1761309) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; oxidoreductase, FAD-binding subunit; putative carbon monoxide dehydrogenase, medium subunit CoxM 1761309 8191998 METDI1879 Methylobacterium extorquens DM4 oxidoreductase, FAD-binding subunit; putative carbon monoxide dehydrogenase, medium subunit CoxM YP_003067440.1 1760407 R 661410 CDS YP_003067441.1 254560346 8191999 1761414..1762109 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 10400605; Product type r : regulator; transcriptional regulatory protein (TetR family) 1762109 8191999 METDI1880 Methylobacterium extorquens DM4 transcriptional regulatory protein (TetR family) YP_003067441.1 1761414 D 661410 CDS YP_003067442.1 254560347 8192000 1762851..1764143 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 11976087; Product type e : enzyme; N-carbamyl-L-amino acid hydrolase (amidase, hydantoinase/carbamoylase family) 1764143 8192000 METDI1881 Methylobacterium extorquens DM4 N-carbamyl-L-amino acid hydrolase (amidase, hydantoinase/carbamoylase family) YP_003067442.1 1762851 D 661410 CDS YP_003067443.1 254560348 8192001 1764494..1765831 1 NC_012988.1 catalyzes the formation of pyruvate and beta-alanine from L-alanine and 3-oxopropanoate; beta alanine--pyruvate transaminase 1765831 aptA 8192001 aptA Methylobacterium extorquens DM4 beta alanine--pyruvate transaminase YP_003067443.1 1764494 D 661410 CDS YP_003067444.1 254560349 8195078 1766159..1766575 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative NAD-dependent aldehyde dehydrogenase 1766575 8195078 METDI1883 Methylobacterium extorquens DM4 putative NAD-dependent aldehyde dehydrogenase YP_003067444.1 1766159 D 661410 CDS YP_003067445.1 254560350 8192002 complement(1766431..1766766) 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 1766766 8192002 METDI1884 Methylobacterium extorquens DM4 hypothetical protein YP_003067445.1 1766431 R 661410 CDS YP_003067446.1 254560351 8192003 1766854..1767099 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1767099 8192003 METDI1885 Methylobacterium extorquens DM4 hypothetical protein YP_003067446.1 1766854 D 661410 CDS YP_003067447.1 254560352 8192004 complement(1767216..1767524) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1767524 8192004 METDI1886 Methylobacterium extorquens DM4 hypothetical protein YP_003067447.1 1767216 R 661410 CDS YP_003067448.1 254560353 8192005 complement(1767798..1771133) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; DEAD/DEAH box helicase domain protein 1771133 8192005 METDI1887 Methylobacterium extorquens DM4 DEAD/DEAH box helicase domain protein YP_003067448.1 1767798 R 661410 CDS YP_003067449.1 254560354 8192006 complement(1771136..1771360) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1771360 8192006 METDI1888 Methylobacterium extorquens DM4 hypothetical protein YP_003067449.1 1771136 R 661410 CDS YP_003067450.1 254560355 8192007 complement(1771412..1772650) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type t : transporter; ammonium transport protein (Amt family) 1772650 amtB 8192007 amtB Methylobacterium extorquens DM4 ammonium transport protein (Amt family) YP_003067450.1 1771412 R 661410 CDS YP_003067451.1 254560356 8195074 complement(1772744..1773757) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative urea transporter 1773757 8195074 METDI1890 Methylobacterium extorquens DM4 putative urea transporter YP_003067451.1 1772744 R 661410 CDS YP_003067452.1 254560357 8192008 complement(1773773..1774708) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type cp : cell process; Urease accessory protein ureD 1774708 ureD 8192008 ureD Methylobacterium extorquens DM4 Urease accessory protein ureD YP_003067452.1 1773773 R 661410 CDS YP_003067453.1 254560358 8196317 complement(1774713..1775360) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type cp : cell process; urease accessory protein UreG 1775360 ureG 8196317 ureG Methylobacterium extorquens DM4 urease accessory protein UreG YP_003067453.1 1774713 R 661410 CDS YP_003067454.1 254560359 8196326 complement(1775381..1776061) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type f : factor; Urease accessory protein ureF 1776061 ureF 8196326 ureF Methylobacterium extorquens DM4 Urease accessory protein ureF YP_003067454.1 1775381 R 661410 CDS YP_003067455.1 254560360 8196322 complement(1776103..1776756) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type f : factor; Urease accessory protein ureE 1776756 ureE 8196322 ureE Methylobacterium extorquens DM4 Urease accessory protein ureE YP_003067455.1 1776103 R 661410 CDS YP_003067456.1 254560361 8196319 complement(1776780..1777163) 1 NC_012988.1 may be involved in chromosome condensation; overexpression in Escherichia coli protects against decondensation by camphor; overexpressing the protein results in an increase in supercoiling; camphor resistance protein CrcB 1777163 ccrB 8196319 ccrB Methylobacterium extorquens DM4 camphor resistance protein CrcB YP_003067456.1 1776780 R 661410 CDS YP_003067457.1 254560362 8192009 complement(1777173..1777538) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12904550, 8844142; Product type m : membrane component; putative integral membrane protein; putative CrcB protein 1777538 8192009 METDI1897 Methylobacterium extorquens DM4 putative integral membrane protein; putative CrcB protein YP_003067457.1 1777173 R 661410 CDS YP_003067458.1 254560363 8192010 complement(1777618..1779336) 1 NC_012988.1 ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 ureC (alpha) and 3 ureAB (gamma/beta) subunits; urease subunit alpha 1779336 ureC 8192010 ureC Methylobacterium extorquens DM4 urease subunit alpha YP_003067458.1 1777618 R 661410 CDS YP_003067459.1 254560364 8196314 complement(1779373..1779783) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type e : enzyme; urease beta subunit 1779783 ureB 8196314 ureB Methylobacterium extorquens DM4 urease beta subunit YP_003067459.1 1779373 R 661410 CDS YP_003067460.1 254560365 8196312 complement(1779808..1780110) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type e : enzyme; urease gamma subunit 1780110 ureA 8196312 ureA Methylobacterium extorquens DM4 urease gamma subunit YP_003067460.1 1779808 R 661410 CDS YP_003067461.1 254560366 8196308 1780750..1782864 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical exported protein, putative outer membrane receptor protein 1782864 8196308 METDI1901 Methylobacterium extorquens DM4 hypothetical exported protein, putative outer membrane receptor protein YP_003067461.1 1780750 D 661410 CDS YP_003067462.1 254560367 8192011 1782861..1783592 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1783592 8192011 METDI1902 Methylobacterium extorquens DM4 hypothetical protein YP_003067462.1 1782861 D 661410 CDS YP_003067463.1 254560368 8192012 complement(1783648..1783863) 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 1783863 8192012 METDI1903 Methylobacterium extorquens DM4 hypothetical protein YP_003067463.1 1783648 R 661410 CDS YP_003067464.1 254560369 8192013 1783995..1784606 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1784606 8192013 METDI1904 Methylobacterium extorquens DM4 hypothetical protein YP_003067464.1 1783995 D 661410 CDS YP_003067465.1 254560370 8192014 complement(1784676..1785077) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1785077 8192014 METDI1905 Methylobacterium extorquens DM4 hypothetical protein YP_003067465.1 1784676 R 661410 CDS YP_003067466.1 254560371 8192015 1785161..1785502 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1785502 8192015 METDI1906 Methylobacterium extorquens DM4 hypothetical protein YP_003067466.1 1785161 D 661410 CDS YP_003067467.1 254560372 8192016 1788192..1788581 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1788581 8192016 METDI1907 Methylobacterium extorquens DM4 hypothetical protein YP_003067467.1 1788192 D 661410 CDS YP_003067468.1 254560373 8192017 1788745..1789308 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative resolvase 1789308 8192017 METDI1908 Methylobacterium extorquens DM4 putative resolvase YP_003067468.1 1788745 D 661410 CDS YP_003067469.1 254560374 8192018 complement(1789322..1789636) 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 1789636 8192018 METDI1909 Methylobacterium extorquens DM4 hypothetical protein YP_003067469.1 1789322 R 661410 CDS YP_003067470.1 254560375 8192019 1789756..1790313 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 1790313 8192019 METDI1910 Methylobacterium extorquens DM4 hypothetical protein YP_003067470.1 1789756 D 661410 CDS YP_003067471.1 254560376 8192020 complement(1790443..1790928) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1790928 8192020 METDI1911 Methylobacterium extorquens DM4 hypothetical protein YP_003067471.1 1790443 R 661410 CDS YP_003067472.1 254560377 8192021 complement(1791081..1791554) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1791554 8192021 METDI1912 Methylobacterium extorquens DM4 hypothetical protein YP_003067472.1 1791081 R 661410 CDS YP_003067473.1 254560378 8192022 1792042..1793616 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; ADP-ribosyl glycohydrolase family protein 1793616 8192022 METDI1913 Methylobacterium extorquens DM4 ADP-ribosyl glycohydrolase family protein YP_003067473.1 1792042 D 661410 CDS YP_003067474.1 254560379 8192023 1793613..1793981 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1793981 8192023 METDI1914 Methylobacterium extorquens DM4 hypothetical protein YP_003067474.1 1793613 D 661410 CDS YP_003067475.1 254560380 8192024 complement(1794199..1796430) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative P4 family phage/plasmid primase 1796430 8192024 METDI1915 Methylobacterium extorquens DM4 putative P4 family phage/plasmid primase YP_003067475.1 1794199 R 661410 CDS YP_003067476.1 254560381 8196258 1798479..1798907 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1798907 8196258 METDI1916 Methylobacterium extorquens DM4 hypothetical protein YP_003067476.1 1798479 D 661410 CDS YP_003067477.1 254560382 8192026 complement(1799177..1799731) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; transposase of ISMex15, IS5 family (ORF 2) 1799731 8192026 METDI1917 Methylobacterium extorquens DM4 transposase of ISMex15, IS5 family (ORF 2) YP_003067477.1 1799177 R 661410 CDS YP_003067478.1 254560383 8192027 complement(1799506..1799931) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; transposase of ISMex15, IS5 family (ORF 1) 1799931 8192027 METDI1918 Methylobacterium extorquens DM4 transposase of ISMex15, IS5 family (ORF 1) YP_003067478.1 1799506 R 661410 CDS YP_003067479.1 254560384 8192028 complement(1799957..1800616) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1800616 8192028 METDI1919 Methylobacterium extorquens DM4 hypothetical protein YP_003067479.1 1799957 R 661410 CDS YP_003067480.1 254560385 8192029 complement(1800604..1800948) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1800948 8192029 METDI1920 Methylobacterium extorquens DM4 hypothetical protein YP_003067480.1 1800604 R 661410 CDS YP_003067481.1 254560386 8192030 complement(1800884..1801237) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative phosphoglycerate/bisphosphoglycerate mutase 1801237 8192030 METDI1921 Methylobacterium extorquens DM4 putative phosphoglycerate/bisphosphoglycerate mutase YP_003067481.1 1800884 R 661410 CDS YP_003067482.1 254560387 8192031 complement(1801460..1801936) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1801936 8192031 METDI1922 Methylobacterium extorquens DM4 hypothetical protein YP_003067482.1 1801460 R 661410 CDS YP_003067483.1 254560388 8192032 complement(1802427..1803104) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; Metal-dependent phosphohydrolase, HD subdomain 1803104 8192032 METDI1923 Methylobacterium extorquens DM4 Metal-dependent phosphohydrolase, HD subdomain YP_003067483.1 1802427 R 661410 CDS YP_003067484.1 254560389 8192033 1803166..1804188 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type r : regulator; Transcriptional regulator, AraC family 1804188 8192033 METDI1924 Methylobacterium extorquens DM4 Transcriptional regulator, AraC family YP_003067484.1 1803166 D 661410 CDS YP_003067485.1 254560390 8192034 complement(1804264..1805106) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1805106 8192034 METDI1925 Methylobacterium extorquens DM4 hypothetical protein YP_003067485.1 1804264 R 661410 CDS YP_003067486.1 254560391 8192035 complement(1805224..1805367) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1805367 8192035 METDI1926 Methylobacterium extorquens DM4 hypothetical protein YP_003067486.1 1805224 R 661410 CDS YP_003067487.1 254560392 8192036 complement(1805759..1806148) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1806148 8192036 METDI1927 Methylobacterium extorquens DM4 hypothetical protein YP_003067487.1 1805759 R 661410 CDS YP_003067488.1 254560393 8192037 complement(1806540..1806806) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1806806 8192037 METDI1928 Methylobacterium extorquens DM4 hypothetical protein YP_003067488.1 1806540 R 661410 CDS YP_003067489.1 254560394 8192038 complement(1807240..1808661) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type prc : putative receptor; putative integral membrane sensor signal transduction histidine kinase precursor 1808661 8192038 METDI1929 Methylobacterium extorquens DM4 putative integral membrane sensor signal transduction histidine kinase precursor YP_003067489.1 1807240 R 661410 CDS YP_003067490.1 254560395 8192039 complement(1808831..1809880) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative sodium/hydrogen exchanger 1809880 8192039 METDI1930 Methylobacterium extorquens DM4 putative sodium/hydrogen exchanger YP_003067490.1 1808831 R 661410 CDS YP_003067491.1 254560396 8192041 1810622..1811047 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; transposase of ISMex15, IS5 family (ORF 1) 1811047 8192041 METDI1932 Methylobacterium extorquens DM4 transposase of ISMex15, IS5 family (ORF 1) YP_003067491.1 1810622 D 661410 CDS YP_003067492.1 254560397 8192042 1810822..1811376 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; transposase of ISMex15, IS5 family (ORF 2) 1811376 8192042 METDI1933 Methylobacterium extorquens DM4 transposase of ISMex15, IS5 family (ORF 2) YP_003067492.1 1810822 D 661410 CDS YP_003067493.1 254560398 8192043 1811637..1811879 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1811879 8192043 METDI1934 Methylobacterium extorquens DM4 hypothetical protein YP_003067493.1 1811637 D 661410 CDS YP_003067494.1 254560399 8192044 complement(1811987..1813171) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1813171 8192044 METDI1935 Methylobacterium extorquens DM4 hypothetical protein YP_003067494.1 1811987 R 661410 CDS YP_003067495.1 254560400 8192045 complement(1813457..1814209) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; transposase of ISMdi3, IS3 family (ORF 2) 1814209 8192045 METDI1936 Methylobacterium extorquens DM4 transposase of ISMdi3, IS3 family (ORF 2) YP_003067495.1 1813457 R 661410 CDS YP_003067496.1 254560401 8192046 complement(1814317..1814598) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; transposase of ISMdi3, IS3 family (ORF 1) 1814598 8192046 METDI1937 Methylobacterium extorquens DM4 transposase of ISMdi3, IS3 family (ORF 1) YP_003067496.1 1814317 R 661410 CDS YP_003067497.1 254560402 8192047 complement(1814850..1815155) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1815155 8192047 METDI1938 Methylobacterium extorquens DM4 hypothetical protein YP_003067497.1 1814850 R 661410 CDS YP_003067498.1 254560403 8192048 complement(1815166..1815849) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1815849 8192048 METDI1939 Methylobacterium extorquens DM4 hypothetical protein YP_003067498.1 1815166 R 661410 CDS YP_003067499.1 254560404 8192049 complement(1815861..1816988) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; hypothetical protein 1816988 8192049 METDI1940 Methylobacterium extorquens DM4 hypothetical protein YP_003067499.1 1815861 R 661410 CDS YP_003067500.1 254560405 8192050 complement(1817098..1819530) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10664842; Product type pe : putative enzyme; putative N,N-dimethylformamidase large subunit 1819530 8192050 METDI1941 Methylobacterium extorquens DM4 putative N,N-dimethylformamidase large subunit YP_003067500.1 1817098 R 661410 CDS YP_003067501.1 254560406 8192051 complement(1819653..1820093) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative N,N-dimethylformamidase, small subunit 1820093 8192051 METDI1942 Methylobacterium extorquens DM4 putative N,N-dimethylformamidase, small subunit YP_003067501.1 1819653 R 661410 CDS YP_003067502.1 254560407 8192052 complement(1820463..1821161) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative leucine/isoleucine/valine transporter subunit (ATP-binding component of ABC superfamily) (livF) 1821161 8192052 METDI1943 Methylobacterium extorquens DM4 putative leucine/isoleucine/valine transporter subunit (ATP-binding component of ABC superfamily) (livF) YP_003067502.1 1820463 R 661410 CDS YP_003067503.1 254560408 8192053 complement(1821164..1821904) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative leucine/isoleucine/valine transporter subunit (ATP-binding component of ABC superfamily) (livG) 1821904 8192053 METDI1944 Methylobacterium extorquens DM4 putative leucine/isoleucine/valine transporter subunit (ATP-binding component of ABC superfamily) (livG) YP_003067503.1 1821164 R 661410 CDS YP_003067504.1 254560409 8192054 complement(1821920..1823041) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative Branched-chain amino acid ABC transporter, permease protein 1823041 8192054 METDI1945 Methylobacterium extorquens DM4 putative Branched-chain amino acid ABC transporter, permease protein YP_003067504.1 1821920 R 661410 CDS YP_003067505.1 254560410 8192055 complement(1823091..1823975) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative ABC transporter, membrane spanning protein 1823975 8192055 METDI1946 Methylobacterium extorquens DM4 putative ABC transporter, membrane spanning protein YP_003067505.1 1823091 R 661410 CDS YP_003067506.1 254560411 8192056 complement(1824043..1825329) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10508151, 10708652, 1762155, 1907262, 7813419; Product type pr : putative regulator; putative aliphatic amidase expression-regulating protein precursor, amiC 1825329 8192056 METDI1947 Methylobacterium extorquens DM4 putative aliphatic amidase expression-regulating protein precursor, amiC YP_003067506.1 1824043 R 661410 CDS YP_003067507.1 254560412 8192057 1826028..1826195 1 NC_012988.1 Evidence 6 : Doubtful CDS; Product type e : enzyme; hypothetical protein 1826195 8192057 METDI1948 Methylobacterium extorquens DM4 hypothetical protein YP_003067507.1 1826028 D 661410 CDS YP_003067508.1 254560413 8192058 1826123..1826338 1 NC_012988.1 Evidence 6 : Doubtful CDS; Product type e : enzyme; hypothetical protein 1826338 8192058 METDI1949 Methylobacterium extorquens DM4 hypothetical protein YP_003067508.1 1826123 D 661410 CDS YP_003067509.1 254560414 8192059 1826981..1827253 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1827253 8192059 METDI1950 Methylobacterium extorquens DM4 hypothetical protein YP_003067509.1 1826981 D 661410 CDS YP_003067510.1 254560415 8192060 complement(1827465..1827641) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1827641 8192060 METDI1951 Methylobacterium extorquens DM4 hypothetical protein YP_003067510.1 1827465 R 661410 CDS YP_003067511.1 254560416 8192061 complement(1827765..1827962) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1827962 8192061 METDI1952 Methylobacterium extorquens DM4 hypothetical protein YP_003067511.1 1827765 R 661410 CDS YP_003067512.1 254560417 8192062 1827989..1829113 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 16522795, 16864586; Product type e : enzyme; PQQ-dependent aldose sugar dehydrogenase precursor (asd) 1829113 yliI 8192062 yliI Methylobacterium extorquens DM4 PQQ-dependent aldose sugar dehydrogenase precursor (asd) YP_003067512.1 1827989 D 661410 CDS YP_003067513.1 254560418 8196373 complement(1829147..1830148) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative alpha/beta hydrolase 1830148 8196373 METDI1954 Methylobacterium extorquens DM4 putative alpha/beta hydrolase YP_003067513.1 1829147 R 661410 CDS YP_003067514.1 254560419 8192063 complement(1830276..1830488) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1830488 8192063 METDI1955 Methylobacterium extorquens DM4 hypothetical protein YP_003067514.1 1830276 R 661410 CDS YP_003067515.1 254560420 8192064 complement(1830475..1830642) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1830642 8192064 METDI1956 Methylobacterium extorquens DM4 hypothetical protein YP_003067515.1 1830475 R 661410 CDS YP_003067516.1 254560421 8192065 1831162..1831827 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1831827 8192065 METDI1957 Methylobacterium extorquens DM4 hypothetical protein YP_003067516.1 1831162 D 661410 CDS YP_003067517.1 254560422 8192066 1831844..1833349 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1833349 8192066 METDI1958 Methylobacterium extorquens DM4 hypothetical protein YP_003067517.1 1831844 D 661410 CDS YP_003067518.1 254560423 8192067 1833415..1834386 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1834386 8192067 METDI1959 Methylobacterium extorquens DM4 hypothetical protein YP_003067518.1 1833415 D 661410 CDS YP_003067519.1 254560424 8192068 1834697..1835512 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative short-chain dehydrogenase/reductase SDR 1835512 8192068 METDI1960 Methylobacterium extorquens DM4 putative short-chain dehydrogenase/reductase SDR YP_003067519.1 1834697 D 661410 CDS YP_003067520.1 254560425 8192069 complement(1835827..1835970) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1835970 8192069 METDI1961 Methylobacterium extorquens DM4 hypothetical protein YP_003067520.1 1835827 R 661410 CDS YP_003067521.1 254560426 8192070 complement(1836638..1837276) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 8110200; Product type e : enzyme; phosphoglyceromutase 1837276 gpmA 8192070 gpmA Methylobacterium extorquens DM4 phosphoglyceromutase YP_003067521.1 1836638 R 661410 CDS YP_003067522.1 254560427 8195528 1837275..1837463 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1837463 8195528 METDI1963 Methylobacterium extorquens DM4 hypothetical protein YP_003067522.1 1837275 D 661410 CDS YP_003067523.1 254560428 8192071 1837548..1838015 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1838015 8192071 METDI1964 Methylobacterium extorquens DM4 hypothetical protein YP_003067523.1 1837548 D 661410 CDS YP_003067524.1 254560429 8192072 complement(1838239..1838484) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1838484 8192072 METDI1965 Methylobacterium extorquens DM4 hypothetical protein YP_003067524.1 1838239 R 661410 CDS YP_003067525.1 254560430 8192073 1838677..1838895 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 1838895 8192073 METDI1966 Methylobacterium extorquens DM4 hypothetical protein YP_003067525.1 1838677 D 661410 CDS YP_003067526.1 254560431 8192074 1838911..1839090 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 1839090 8192074 METDI1967 Methylobacterium extorquens DM4 hypothetical protein YP_003067526.1 1838911 D 661410 CDS YP_003067527.1 254560432 8192075 1839087..1839212 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 1839212 8192075 METDI1968 Methylobacterium extorquens DM4 hypothetical protein YP_003067527.1 1839087 D 661410 CDS YP_003067528.1 254560433 8192076 1839553..1839984 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1839984 8192076 METDI1969 Methylobacterium extorquens DM4 hypothetical protein YP_003067528.1 1839553 D 661410 CDS YP_003067529.1 254560434 8192077 1840097..1840861 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative short-chain dehydrogenase/reductase SDR 1840861 8192077 METDI1970 Methylobacterium extorquens DM4 putative short-chain dehydrogenase/reductase SDR YP_003067529.1 1840097 D 661410 CDS YP_003067530.1 254560435 8192078 complement(1840941..1841477) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1841477 8192078 METDI1971 Methylobacterium extorquens DM4 hypothetical protein YP_003067530.1 1840941 R 661410 CDS YP_003067531.1 254560436 8192079 1840947..1841126 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1841126 8192079 METDI1972 Methylobacterium extorquens DM4 hypothetical protein YP_003067531.1 1840947 D 661410 CDS YP_003067532.1 254560437 8192080 complement(1841513..1842403) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative Acetyl-hydrolase 1842403 8192080 METDI1973 Methylobacterium extorquens DM4 putative Acetyl-hydrolase YP_003067532.1 1841513 R 661410 CDS YP_003067533.1 254560438 8192081 complement(1843203..1844708) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 9045826; Product type pr : putative regulator; putative hybrid histidine kinase with PAS sensor and response receiver regulator domains 1844708 8192081 METDI1974 Methylobacterium extorquens DM4 putative hybrid histidine kinase with PAS sensor and response receiver regulator domains YP_003067533.1 1843203 R 661410 CDS YP_003067534.1 254560439 8192082 complement(1844710..1846695) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative sensor histidine kinase with multiple PAS and GAF domains 1846695 8192082 METDI1975 Methylobacterium extorquens DM4 putative sensor histidine kinase with multiple PAS and GAF domains YP_003067534.1 1844710 R 661410 CDS YP_003067535.1 254560440 8192083 1847185..1848636 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor; putative cytochrome P450 1848636 8192083 METDI1976 Methylobacterium extorquens DM4 putative cytochrome P450 YP_003067535.1 1847185 D 661410 CDS YP_003067536.1 254560441 8192084 1848614..1851061 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative sensory box-containing diguanylate cyclase/phosphodiesterase; permease, PAS/PAC, GGDEF and EAL domains 1851061 8192084 METDI1977 Methylobacterium extorquens DM4 putative sensory box-containing diguanylate cyclase/phosphodiesterase; permease, PAS/PAC, GGDEF and EAL domains YP_003067536.1 1848614 D 661410 CDS YP_003067537.1 254560442 8192085 complement(1851233..1852072) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative tRNA delta(2)-isopentenylpyrophosphate transferase (IPP transferase) (Isopentenyl-diphosphate:tRNA isopentenyltransferase) (IPTase) (IPPT) 1852072 8192085 METDI1978 Methylobacterium extorquens DM4 putative tRNA delta(2)-isopentenylpyrophosphate transferase (IPP transferase) (Isopentenyl-diphosphate:tRNA isopentenyltransferase) (IPTase) (IPPT) YP_003067537.1 1851233 R 661410 CDS YP_003067538.1 254560443 8192086 complement(1852085..1853065) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10960107, 9274035; Product type pe : putative enzyme; putative nosX precursor (nitrous oxide reductase) 1853065 8192086 METDI1979 Methylobacterium extorquens DM4 putative nosX precursor (nitrous oxide reductase) YP_003067538.1 1852085 R 661410 CDS YP_003067539.1 254560444 8192087 complement(1853071..1855188) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12186758; Product type pr : putative regulator; putative regulatory protein NosR 1855188 8192087 METDI1980 Methylobacterium extorquens DM4 putative regulatory protein NosR YP_003067539.1 1853071 R 661410 CDS YP_003067540.1 254560445 8192088 complement(1855185..1856201) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1856201 8192088 METDI1981 Methylobacterium extorquens DM4 hypothetical protein YP_003067540.1 1855185 R 661410 CDS YP_003067541.1 254560446 8192089 complement(1856249..1857475) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1857475 8192089 METDI1982 Methylobacterium extorquens DM4 hypothetical protein YP_003067541.1 1856249 R 661410 CDS YP_003067542.1 254560447 8192090 1857637..1858059 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 10075429; Product type c : carrier; cytochrome c550 1858059 8192090 METDI1983 Methylobacterium extorquens DM4 cytochrome c550 YP_003067542.1 1857637 D 661410 CDS YP_003067543.1 254560448 8192091 1858074..1858940 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1858940 8192091 METDI1984 Methylobacterium extorquens DM4 hypothetical protein YP_003067543.1 1858074 D 661410 CDS YP_003067544.1 254560449 8192092 1859231..1860994 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 10736230; Product type e : enzyme; Quinoprotein ethanol dehydrogenase precursor (QEDH) 1860994 exa 8192092 exa Methylobacterium extorquens DM4 Quinoprotein ethanol dehydrogenase precursor (QEDH) YP_003067544.1 1859231 D 661410 CDS YP_003067545.1 254560450 8195338 complement(1861316..1862908) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative transporter, major facilitator superfamily 1862908 8195338 METDI1986 Methylobacterium extorquens DM4 putative transporter, major facilitator superfamily YP_003067545.1 1861316 R 661410 CDS YP_003067546.1 254560451 8192093 1862811..1863212 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1863212 8192093 METDI1987 Methylobacterium extorquens DM4 hypothetical protein YP_003067546.1 1862811 D 661410 CDS YP_003067547.1 254560452 8192094 1863272..1863514 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1863514 8192094 METDI1988 Methylobacterium extorquens DM4 hypothetical protein YP_003067547.1 1863272 D 661410 CDS YP_003067548.1 254560453 8192095 complement(1863492..1863737) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1863737 8192095 METDI1989 Methylobacterium extorquens DM4 hypothetical protein YP_003067548.1 1863492 R 661410 CDS YP_003067549.1 254560454 8192096 complement(1863734..1864426) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1864426 8192096 METDI1990 Methylobacterium extorquens DM4 hypothetical protein YP_003067549.1 1863734 R 661410 CDS YP_003067550.1 254560455 8192097 complement(1864423..1864581) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1864581 8192097 METDI1991 Methylobacterium extorquens DM4 hypothetical protein YP_003067550.1 1864423 R 661410 CDS YP_003067551.1 254560456 8192098 complement(1864776..1864904) 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 1864904 8192098 METDI1992 Methylobacterium extorquens DM4 hypothetical protein YP_003067551.1 1864776 R 661410 CDS YP_003067552.1 254560457 8192099 complement(1864948..1865445) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1865445 8192099 METDI1993 Methylobacterium extorquens DM4 hypothetical protein YP_003067552.1 1864948 R 661410 CDS YP_003067553.1 254560458 8192100 complement(1865511..1866272) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1866272 8192100 METDI1994 Methylobacterium extorquens DM4 hypothetical protein YP_003067553.1 1865511 R 661410 CDS YP_003067554.1 254560459 8192101 1866335..1866661 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1866661 8192101 METDI1995 Methylobacterium extorquens DM4 hypothetical protein YP_003067554.1 1866335 D 661410 CDS YP_003067555.1 254560460 8192102 complement(1866680..1867189) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1867189 8192102 METDI1996 Methylobacterium extorquens DM4 hypothetical protein YP_003067555.1 1866680 R 661410 CDS YP_003067556.1 254560461 8192103 complement(1867186..1869303) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative peptidase 1869303 8192103 METDI1997 Methylobacterium extorquens DM4 putative peptidase YP_003067556.1 1867186 R 661410 CDS YP_003067557.1 254560462 8192104 1869855..1870121 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1870121 8192104 METDI1998 Methylobacterium extorquens DM4 hypothetical protein YP_003067557.1 1869855 D 661410 CDS YP_003067558.1 254560463 8192105 1870136..1870285 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1870285 8192105 METDI1999 Methylobacterium extorquens DM4 hypothetical protein YP_003067558.1 1870136 D 661410 CDS YP_003067559.1 254560464 8192106 complement(1870344..1870691) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1870691 8192106 METDI2000 Methylobacterium extorquens DM4 hypothetical protein YP_003067559.1 1870344 R 661410 CDS YP_003067560.1 254560465 8192107 complement(1870775..1871521) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; Short-chain dehydrogenase/reductase SDR 1871521 8192107 METDI2001 Methylobacterium extorquens DM4 Short-chain dehydrogenase/reductase SDR YP_003067560.1 1870775 R 661410 CDS YP_003067561.1 254560466 8192108 complement(1871641..1872555) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcriptional regulator, LysR family 1872555 8192108 METDI2002 Methylobacterium extorquens DM4 putative transcriptional regulator, LysR family YP_003067561.1 1871641 R 661410 CDS YP_003067562.1 254560467 8192109 complement(1872729..1873565) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1873565 8192109 METDI2003 Methylobacterium extorquens DM4 hypothetical protein YP_003067562.1 1872729 R 661410 CDS YP_003067563.1 254560468 8192110 1873733..1874545 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1874545 8192110 METDI2004 Methylobacterium extorquens DM4 hypothetical protein YP_003067563.1 1873733 D 661410 CDS YP_003067564.1 254560469 8192111 1874545..1874871 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10866828; Product type pe : putative enzyme; putative cytochrome c, class I 1874871 8192111 METDI2005 Methylobacterium extorquens DM4 putative cytochrome c, class I YP_003067564.1 1874545 D 661410 CDS YP_003067565.1 254560470 8192112 complement(1874947..1875699) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 1319772, 1551834, 1766374, 7559356; Product type r : regulator; transcriptional regulator, Crp/Fnr family 1875699 8192112 METDI2006 Methylobacterium extorquens DM4 transcriptional regulator, Crp/Fnr family YP_003067565.1 1874947 R 661410 CDS YP_003067566.1 254560471 8192113 complement(1876064..1877719) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative ABC transporter related, fused ATPase and permease domains (CydD-like) 1877719 8192113 METDI2007 Methylobacterium extorquens DM4 putative ABC transporter related, fused ATPase and permease domains (CydD-like) YP_003067566.1 1876064 R 661410 CDS YP_003067567.1 254560472 8192114 complement(1877674..1879317) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative ABC transporter related, fused ATPase and permease domains (CydD-like) 1879317 8192114 METDI2009 Methylobacterium extorquens DM4 putative ABC transporter related, fused ATPase and permease domains (CydD-like) YP_003067567.1 1877674 R 661410 CDS YP_003067568.1 254560473 8192115 1879417..1881006 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type e : enzyme; cytochrome d terminal oxidase, polypeptide subunit I 1881006 cydA 8192115 cydA Methylobacterium extorquens DM4 cytochrome d terminal oxidase, polypeptide subunit I YP_003067568.1 1879417 D 661410 CDS YP_003067569.1 254560474 8195239 1881072..1882226 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type e : enzyme; cytochrome d terminal oxidase, polypeptide subunit II 1882226 cydB 8195239 cydB Methylobacterium extorquens DM4 cytochrome d terminal oxidase, polypeptide subunit II YP_003067569.1 1881072 D 661410 CDS YP_003067570.1 254560475 8195240 1882280..1882411 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; putative exported protein, putative cyd operon protein 1882411 8195240 METDI2012 Methylobacterium extorquens DM4 putative exported protein, putative cyd operon protein YP_003067570.1 1882280 D 661410 CDS YP_003067571.1 254560476 8192116 complement(1882644..1883396) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 2653814; Product type pr : putative regulator; transcriptional regulator, DeoR family 1883396 8192116 METDI2013 Methylobacterium extorquens DM4 transcriptional regulator, DeoR family YP_003067571.1 1882644 R 661410 CDS YP_003067572.1 254560477 8192117 complement(1883562..1885136) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative Glutamyl-tRNA(Gln) amidotransferase subunit A (Glu-ADT subunit A) 1885136 8192117 METDI2014 Methylobacterium extorquens DM4 putative Glutamyl-tRNA(Gln) amidotransferase subunit A (Glu-ADT subunit A) YP_003067572.1 1883562 R 661410 CDS YP_003067573.1 254560478 8192118 1885663..1888089 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 10199407; hypothetical protein 1888089 8192118 METDI2015 Methylobacterium extorquens DM4 hypothetical protein YP_003067573.1 1885663 D 661410 CDS YP_003067574.1 254560479 8192119 1888294..1889034 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1889034 8192119 METDI2016 Methylobacterium extorquens DM4 hypothetical protein YP_003067574.1 1888294 D 661410 CDS YP_003067575.1 254560480 8192120 1889363..1891867 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 7860585; Product type e : enzyme; Cellulose synthase (UDP-forming) 1891867 celA 8192120 celA Methylobacterium extorquens DM4 Cellulose synthase (UDP-forming) YP_003067575.1 1889363 D 661410 CDS YP_003067576.1 254560481 8195161 1891864..1894506 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10376842; Product type pe : putative enzyme; putative CelB-like protein 1894506 8195161 METDI2018 Methylobacterium extorquens DM4 putative CelB-like protein YP_003067576.1 1891864 D 661410 CDS YP_003067577.1 254560482 8192121 1894506..1895789 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10376842; Product type pe : putative enzyme; putative cellulase, endoglucanase (celC) 1895789 8192121 METDI2019 Methylobacterium extorquens DM4 putative cellulase, endoglucanase (celC) YP_003067577.1 1894506 D 661410 CDS YP_003067578.1 254560483 8192122 1895774..1897837 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1897837 8192122 METDI2020 Methylobacterium extorquens DM4 hypothetical protein YP_003067578.1 1895774 D 661410 CDS YP_003067579.1 254560484 8192123 1897834..1898847 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1898847 8192123 METDI2021 Methylobacterium extorquens DM4 hypothetical protein YP_003067579.1 1897834 D 661410 CDS YP_003067580.1 254560485 8196259 complement(1906274..1910164) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative glycosyl transferase 1910164 8196259 METDI2028 Methylobacterium extorquens DM4 putative glycosyl transferase YP_003067580.1 1906274 R 661410 CDS YP_003067581.1 254560486 8192125 complement(1910188..1910556) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1910556 8192125 METDI2029 Methylobacterium extorquens DM4 hypothetical protein YP_003067581.1 1910188 R 661410 CDS YP_003067582.1 254560487 8192126 1910821..1911714 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1911714 8192126 METDI2030 Methylobacterium extorquens DM4 hypothetical protein YP_003067582.1 1910821 D 661410 CDS YP_003067583.1 254560488 8192127 complement(1912091..1912861) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1912861 8192127 METDI2031 Methylobacterium extorquens DM4 hypothetical protein YP_003067583.1 1912091 R 661410 CDS YP_003067584.1 254560489 8192128 complement(1912947..1913510) 1 NC_012988.1 Bacteria have multiple sigma factors which are active under specific conditions; the sigma factor binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; possibly involved in prevention of copper toxicity; RNA polymerase sigma factor 1913510 8192128 METDI2032 Methylobacterium extorquens DM4 RNA polymerase sigma factor YP_003067584.1 1912947 R 661410 CDS YP_003067585.1 254560490 8192129 complement(1913747..1915051) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier; putative Peptidoglycan-binding protein 1915051 8192129 METDI2033 Methylobacterium extorquens DM4 putative Peptidoglycan-binding protein YP_003067585.1 1913747 R 661410 CDS YP_003067586.1 254560491 8192130 1915336..1915749 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1915749 8192130 METDI2034 Methylobacterium extorquens DM4 hypothetical protein YP_003067586.1 1915336 D 661410 CDS YP_003067587.1 254560492 8192131 1915799..1916866 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1916866 8192131 METDI2035 Methylobacterium extorquens DM4 hypothetical protein YP_003067587.1 1915799 D 661410 CDS YP_003067588.1 254560493 8192132 1916982..1917506 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1917506 8192132 METDI2036 Methylobacterium extorquens DM4 hypothetical protein YP_003067588.1 1916982 D 661410 CDS YP_003067589.1 254560494 8192133 1917496..1918143 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1918143 8192133 METDI2037 Methylobacterium extorquens DM4 hypothetical protein YP_003067589.1 1917496 D 661410 CDS YP_003067590.1 254560495 8192134 1918287..1918643 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1918643 8192134 METDI2038 Methylobacterium extorquens DM4 hypothetical protein YP_003067590.1 1918287 D 661410 CDS YP_003067591.1 254560496 8192135 1918686..1920833 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type prc : putative receptor; putative outer membrane receptor for iron transport 1920833 8192135 METDI2039 Methylobacterium extorquens DM4 putative outer membrane receptor for iron transport YP_003067591.1 1918686 D 661410 CDS YP_003067592.1 254560497 8192136 1921079..1922926 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1922926 8192136 METDI2040 Methylobacterium extorquens DM4 hypothetical protein YP_003067592.1 1921079 D 661410 CDS YP_003067593.1 254560498 8192137 complement(1923077..1924549) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1924549 8192137 METDI2041 Methylobacterium extorquens DM4 hypothetical protein YP_003067593.1 1923077 R 661410 CDS YP_003067594.1 254560499 8192138 complement(1924654..1925313) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 11106435, 9826185; Product type r : regulator; transcriptional regulator, GntR family 1925313 8192138 METDI2042 Methylobacterium extorquens DM4 transcriptional regulator, GntR family YP_003067594.1 1924654 R 661410 CDS YP_003067595.1 254560500 8192139 1925489..1926511 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type t : transporter; putative tripartite ATP-independent periplasmic transporter, periplasmic binding protein precursor (tat pathway signal) 1926511 8192139 METDI2043 Methylobacterium extorquens DM4 putative tripartite ATP-independent periplasmic transporter, periplasmic binding protein precursor (tat pathway signal) YP_003067595.1 1925489 D 661410 CDS YP_003067596.1 254560501 8192140 1926508..1927233 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative tripartite ATP-independent periplasmic transporter, permease (DctQ) subunit; putative membrane protein 1927233 8192140 METDI2044 Methylobacterium extorquens DM4 putative tripartite ATP-independent periplasmic transporter, permease (DctQ) subunit; putative membrane protein YP_003067596.1 1926508 D 661410 CDS YP_003067597.1 254560502 8192141 1927230..1928582 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative tripartite ATP-independent periplasmic transporter, putative membrane component 1928582 8192141 METDI2045 Methylobacterium extorquens DM4 putative tripartite ATP-independent periplasmic transporter, putative membrane component YP_003067597.1 1927230 D 661410 CDS YP_003067598.1 254560503 8192142 1928750..1928947 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1928947 8192142 METDI2046 Methylobacterium extorquens DM4 hypothetical protein YP_003067598.1 1928750 D 661410 CDS YP_003067600.1 254560505 8192144 1929727..1929960 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 1929960 8192144 METDI2048 Methylobacterium extorquens DM4 hypothetical protein YP_003067600.1 1929727 D 661410 CDS YP_003067601.1 254560506 8192145 1930028..1931074 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 9108143, 9406390; Product type e : enzyme; Cysteine synthase 1931074 cysK 8192145 cysK Methylobacterium extorquens DM4 Cysteine synthase YP_003067601.1 1930028 D 661410 CDS YP_003067602.1 254560507 8195258 1931187..1931342 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1931342 8195258 METDI2050 Methylobacterium extorquens DM4 hypothetical protein YP_003067602.1 1931187 D 661410 CDS YP_003067603.1 254560508 8192146 complement(1931441..1932916) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1932916 8192146 METDI2051 Methylobacterium extorquens DM4 hypothetical protein YP_003067603.1 1931441 R 661410 CDS YP_003067604.1 254560509 8192147 1933096..1933542 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1933542 8192147 METDI2052 Methylobacterium extorquens DM4 hypothetical protein YP_003067604.1 1933096 D 661410 CDS YP_003067605.1 254560510 8192148 1933812..1939118 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1939118 8192148 METDI2053 Methylobacterium extorquens DM4 hypothetical protein YP_003067605.1 1933812 D 661410 CDS YP_003067606.1 254560511 8192149 1939123..1941324 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 8335642; Product type e : enzyme; penicillin binding protein 1941324 pbpC 8192149 pbpC Methylobacterium extorquens DM4 penicillin binding protein YP_003067606.1 1939123 D 661410 CDS YP_003067607.1 254560512 8195830 1941463..1941783 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type t : transporter; multidrug efflux system protein 1941783 sugE 8195830 sugE Methylobacterium extorquens DM4 multidrug efflux system protein YP_003067607.1 1941463 D 661410 CDS YP_003067608.1 254560513 8196174 complement(1941788..1942588) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1942588 8196174 METDI2056 Methylobacterium extorquens DM4 hypothetical protein YP_003067608.1 1941788 R 661410 CDS YP_003067609.1 254560514 8192150 complement(1942640..1943275) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative sortase (surface protein transpeptidase) precursor 1943275 8192150 METDI2057 Methylobacterium extorquens DM4 putative sortase (surface protein transpeptidase) precursor YP_003067609.1 1942640 R 661410 CDS YP_003067610.1 254560515 8192151 complement(1943272..1945473) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1945473 8192151 METDI2058 Methylobacterium extorquens DM4 hypothetical protein YP_003067610.1 1943272 R 661410 CDS YP_003067611.1 254560516 8192152 1945718..1946329 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative phosphoglycerate mutase domain protein 1946329 8192152 METDI2059 Methylobacterium extorquens DM4 putative phosphoglycerate mutase domain protein YP_003067611.1 1945718 D 661410 CDS YP_003067612.1 254560517 8192153 complement(1946417..1947157) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1947157 8192153 METDI2060 Methylobacterium extorquens DM4 hypothetical protein YP_003067612.1 1946417 R 661410 CDS YP_003067613.1 254560518 8192154 complement(1947268..1948278) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1948278 8192154 METDI2061 Methylobacterium extorquens DM4 hypothetical protein YP_003067613.1 1947268 R 661410 CDS YP_003067614.1 254560519 8192155 complement(1948269..1948946) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1948946 8192155 METDI2062 Methylobacterium extorquens DM4 hypothetical protein YP_003067614.1 1948269 R 661410 CDS YP_003067615.1 254560520 8192156 complement(1949060..1949521) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 10339610, 12196152, 7715601, 9524269; Product type e : enzyme; cytochrome c-type biogenesis protein CycL precursor 1949521 cycL 8192156 cycL Methylobacterium extorquens DM4 cytochrome c-type biogenesis protein CycL precursor YP_003067615.1 1949060 R 661410 CDS YP_003067616.1 254560521 8195238 complement(1949518..1951518) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 11744735, 7635817; Product type e : enzyme; cytochrome c-type biogenesis protein CycK; heme lyase 1951518 cycK 8195238 cycK Methylobacterium extorquens DM4 cytochrome c-type biogenesis protein CycK; heme lyase YP_003067616.1 1949518 R 661410 CDS YP_003067617.1 254560522 8195237 complement(1951565..1952098) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type f : factor; cytochrome c-type biogenesis protein CycJ; periplasmic heme chaperone 1952098 cycJ 8195237 cycJ Methylobacterium extorquens DM4 cytochrome c-type biogenesis protein CycJ; periplasmic heme chaperone YP_003067617.1 1951565 R 661410 CDS YP_003067618.1 254560523 8195236 complement(1952261..1953844) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 7715602, 8231805; Product type f : factor; cytochrome c-type biogenesis protein CycH 1953844 cycH 8195236 cycH Methylobacterium extorquens DM4 cytochrome c-type biogenesis protein CycH YP_003067618.1 1952261 R 661410 CDS YP_003067619.1 254560524 8195235 complement(1953991..1955406) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type rc : receptor; integral membrane sensor signal transduction histidine kinase precursor 1955406 8195235 METDI2067 Methylobacterium extorquens DM4 integral membrane sensor signal transduction histidine kinase precursor YP_003067619.1 1953991 R 661410 CDS YP_003067620.1 254560525 8192157 complement(1955403..1955660) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1955660 8192157 METDI2068 Methylobacterium extorquens DM4 hypothetical protein YP_003067620.1 1955403 R 661410 CDS YP_003067621.1 254560526 8192158 complement(1955793..1956470) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative phoP: DNA-binding response regulator in two-component regulatory system with PhoQ 1956470 8192158 METDI2069 Methylobacterium extorquens DM4 putative phoP: DNA-binding response regulator in two-component regulatory system with PhoQ YP_003067621.1 1955793 R 661410 CDS YP_003067622.1 254560527 8192159 complement(1956509..1957048) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1957048 8192159 METDI2070 Methylobacterium extorquens DM4 hypothetical protein YP_003067622.1 1956509 R 661410 CDS YP_003067623.1 254560528 8192160 complement(1957062..1957310) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1957310 8192160 METDI2071 Methylobacterium extorquens DM4 hypothetical protein YP_003067623.1 1957062 R 661410 CDS YP_003067624.1 254560529 8192161 complement(1957332..1957685) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1957685 8192161 METDI2072 Methylobacterium extorquens DM4 hypothetical protein YP_003067624.1 1957332 R 661410 CDS YP_003067625.1 254560530 8192162 complement(1957735..1958337) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1958337 8192162 METDI2073 Methylobacterium extorquens DM4 hypothetical protein YP_003067625.1 1957735 R 661410 CDS YP_003067626.1 254560531 8192163 complement(1958371..1958934) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1958934 8192163 METDI2074 Methylobacterium extorquens DM4 hypothetical protein YP_003067626.1 1958371 R 661410 CDS YP_003067627.1 254560532 8192164 complement(1959054..1959890) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1959890 8192164 METDI2075 Methylobacterium extorquens DM4 hypothetical protein YP_003067627.1 1959054 R 661410 CDS YP_003067628.1 254560533 8192165 complement(1959437..1960135) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1960135 8192165 METDI2076 Methylobacterium extorquens DM4 hypothetical protein YP_003067628.1 1959437 R 661410 CDS YP_003067629.1 254560534 8192166 complement(1960160..1964062) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1964062 8192166 METDI2077 Methylobacterium extorquens DM4 hypothetical protein YP_003067629.1 1960160 R 661410 CDS YP_003067630.1 254560535 8192167 complement(1964086..1964550) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12620121; Product type pe : putative enzyme; putative phage cell wall peptidase 1964550 8192167 METDI2078 Methylobacterium extorquens DM4 putative phage cell wall peptidase YP_003067630.1 1964086 R 661410 CDS YP_003067631.1 254560536 8192168 complement(1964558..1965451) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1965451 8192168 METDI2079 Methylobacterium extorquens DM4 hypothetical protein YP_003067631.1 1964558 R 661410 CDS YP_003067632.1 254560537 8192169 complement(1965462..1966103) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1966103 8192169 METDI2080 Methylobacterium extorquens DM4 hypothetical protein YP_003067632.1 1965462 R 661410 CDS YP_003067633.1 254560538 8192170 complement(1966115..1966744) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1966744 8192170 METDI2081 Methylobacterium extorquens DM4 hypothetical protein YP_003067633.1 1966115 R 661410 CDS YP_003067634.1 254560539 8192171 complement(1966741..1966971) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1966971 8192171 METDI2082 Methylobacterium extorquens DM4 hypothetical protein YP_003067634.1 1966741 R 661410 CDS YP_003067635.1 254560540 8192172 complement(1966968..1967300) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1967300 8192172 METDI2083 Methylobacterium extorquens DM4 hypothetical protein YP_003067635.1 1966968 R 661410 CDS YP_003067636.1 254560541 8192173 complement(1967297..1967680) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Phage major tail protein 1967680 8192173 METDI2084 Methylobacterium extorquens DM4 Phage major tail protein YP_003067636.1 1967297 R 661410 CDS YP_003067637.1 254560542 8192174 complement(1967737..1968156) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1968156 8192174 METDI2085 Methylobacterium extorquens DM4 hypothetical protein YP_003067637.1 1967737 R 661410 CDS YP_003067638.1 254560543 8192175 complement(1968153..1968494) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1968494 8192175 METDI2086 Methylobacterium extorquens DM4 hypothetical protein YP_003067638.1 1968153 R 661410 CDS YP_003067639.1 254560544 8192176 complement(1968517..1969092) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1969092 8192176 METDI2087 Methylobacterium extorquens DM4 hypothetical protein YP_003067639.1 1968517 R 661410 CDS YP_003067640.1 254560545 8192177 1969126..1969881 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative Peptidase S1 and S6, chymotrypsin/Hap 1969881 8192177 METDI2088 Methylobacterium extorquens DM4 putative Peptidase S1 and S6, chymotrypsin/Hap YP_003067640.1 1969126 D 661410 CDS YP_003067641.1 254560546 8192178 1970029..1970877 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative peptidase 1970877 8192178 METDI2089 Methylobacterium extorquens DM4 putative peptidase YP_003067641.1 1970029 D 661410 CDS YP_003067642.1 254560547 8192179 complement(1970884..1972149) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; phage major capsid protein 1972149 8192179 METDI2090 Methylobacterium extorquens DM4 phage major capsid protein YP_003067642.1 1970884 R 661410 CDS YP_003067643.1 254560548 8192180 complement(1972182..1972652) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; phage prohead protease 1972652 8192180 METDI2091 Methylobacterium extorquens DM4 phage prohead protease YP_003067643.1 1972182 R 661410 CDS YP_003067644.1 254560549 8192181 complement(1972710..1973882) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 7723020; Product type h : extrachromosomal origin; Phage portal protein, HK97 1973882 8192181 METDI2092 Methylobacterium extorquens DM4 Phage portal protein, HK97 YP_003067644.1 1972710 R 661410 CDS YP_003067645.1 254560550 8192182 complement(1973929..1975194) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1975194 8192182 METDI2093 Methylobacterium extorquens DM4 hypothetical protein YP_003067645.1 1973929 R 661410 CDS YP_003067646.1 254560551 8192183 complement(1975157..1975585) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1975585 8192183 METDI2094 Methylobacterium extorquens DM4 hypothetical protein YP_003067646.1 1975157 R 661410 CDS YP_003067648.1 254560553 8192185 complement(1976010..1976771) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 2211521, 8226690; Product type e : enzyme; Precorrin-3B C(17)-methyltransferase (Precorrin-3 methyltransferase) (Precorrin-3 methylase) 1976771 cobJ 8192185 cobJ Methylobacterium extorquens DM4 Precorrin-3B C(17)-methyltransferase (Precorrin-3 methyltransferase) (Precorrin-3 methylase) YP_003067648.1 1976010 R 661410 CDS YP_003067649.1 254560554 8195190 complement(1976768..1977565) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 2211521; Product type e : enzyme; Precorrin-2 C(20)-methyltransferase (S-adenosyl-L-methionine--precorrin-2 methyltransferase) (SP2MT) 1977565 cobI 8195190 cobI Methylobacterium extorquens DM4 Precorrin-2 C(20)-methyltransferase (S-adenosyl-L-methionine--precorrin-2 methyltransferase) (SP2MT) YP_003067649.1 1976768 R 661410 CDS YP_003067650.1 254560555 8195189 complement(1977565..1978197) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 11470433, 1732194, 2211521; Product type e : enzyme; Precorrin-8X methylmutase (Precorrin isomerase) (HBA synthase) 1978197 cobH 8195189 cobH Methylobacterium extorquens DM4 Precorrin-8X methylmutase (Precorrin isomerase) (HBA synthase) YP_003067650.1 1977565 R 661410 CDS YP_003067651.1 254560556 8195188 complement(1978204..1979490) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 2211521; Product type e : enzyme; precorrin-3B synthase 1979490 cobG 8195188 cobG Methylobacterium extorquens DM4 precorrin-3B synthase YP_003067651.1 1978204 R 661410 CDS YP_003067652.1 254560557 8195187 complement(1979487..1982918) 1 NC_012988.1 with CobST catalyzes the formation of cobyrinic acid a,c-diamide from hydrogenobyrinic acid a,c-diamide in an ATP-dependent manner; involved in porphyrin and chlorophyll metabolism; vitamin B12 metabolism; cobaltochelatase subunit CobN 1982918 cobN 8195187 cobN Methylobacterium extorquens DM4 cobaltochelatase subunit CobN YP_003067652.1 1979487 R 661410 CDS YP_003067653.1 254560558 8192186 complement(1982932..1983828) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1983828 8192186 METDI2101 Methylobacterium extorquens DM4 hypothetical protein YP_003067653.1 1982932 R 661410 CDS YP_003067654.1 254560559 8192187 complement(1983825..1984859) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 1655697; Product type e : enzyme; cobalamin biosynthesis protein CobW 1984859 cobW 8192187 cobW Methylobacterium extorquens DM4 cobalamin biosynthesis protein CobW YP_003067654.1 1983825 R 661410 CDS YP_003067655.1 254560560 8195200 complement(1984856..1985263) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1985263 8195200 METDI2103 Methylobacterium extorquens DM4 hypothetical protein YP_003067655.1 1984856 R 661410 CDS YP_003067656.1 254560561 8192188 complement(1985256..1986023) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1986023 8192188 METDI2104 Methylobacterium extorquens DM4 hypothetical protein YP_003067656.1 1985256 R 661410 CDS YP_003067657.1 254560562 8192189 complement(1986054..1986236) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; hypothetical protein 1986236 8192189 METDI2105 Methylobacterium extorquens DM4 hypothetical protein YP_003067657.1 1986054 R 661410 CDS YP_003067658.1 254560563 8195031 complement(1986521..1986943) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1986943 8195031 METDI2106 Methylobacterium extorquens DM4 hypothetical protein YP_003067658.1 1986521 R 661410 CDS YP_003067659.1 254560564 8192191 complement(1986930..1987421) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 12612613, 12694921, 9402023; Product type r : regulator; transcriptional regulator, MarR family 1987421 8192191 METDI2107 Methylobacterium extorquens DM4 transcriptional regulator, MarR family YP_003067659.1 1986930 R 661410 CDS YP_003067660.1 254560565 8192192 1987503..1988033 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 1655696, 7635831; Product type e : enzyme; Bifunctional adenosylcobalamin biosynthesis protein cobP 1988033 cobP 8192192 cobP Methylobacterium extorquens DM4 Bifunctional adenosylcobalamin biosynthesis protein cobP YP_003067660.1 1987503 D 661410 CDS YP_003067661.1 254560566 8195194 1988033..1988635 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 12080060, 1655697, 1917862, 2403541, 2644187, 7860601, 7916712; Product type e : enzyme; cob(I)alamin adenolsyltransferase/cobinamide ATP-dependent adenolsyltransferase 1988635 cobA 8195194 cobA Methylobacterium extorquens DM4 cob(I)alamin adenolsyltransferase/cobinamide ATP-dependent adenolsyltransferase YP_003067661.1 1988033 D 661410 CDS YP_003067662.1 254560567 8195181 1989200..1990741 1 NC_012988.1 class II family (does not require metal); tetrameric enzyme; fumarase C; reversibly converts (S)-malate to fumarate and water; functions in the TCA cycle; fumarate hydratase 1990741 fumC 8195181 fumC Methylobacterium extorquens DM4 fumarate hydratase YP_003067662.1 1989200 D 661410 CDS YP_003067663.1 254560568 8195459 complement(1990856..1991395) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; formaldehyde activating enzyme homolog 1991395 fae 8195459 fae Methylobacterium extorquens DM4 formaldehyde activating enzyme homolog YP_003067663.1 1990856 R 661410 CDS YP_003067664.1 254560569 8195353 1991576..1991857 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1991857 8195353 METDI2112 Methylobacterium extorquens DM4 hypothetical protein YP_003067664.1 1991576 D 661410 CDS YP_003067665.1 254560570 8192193 complement(1991883..1992329) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1992329 8192193 METDI2113 Methylobacterium extorquens DM4 hypothetical protein YP_003067665.1 1991883 R 661410 CDS YP_003067666.1 254560571 8192194 1992550..1993434 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 9169427, 9578475; Product type pe : putative enzyme; putative alpha/beta hydrolase, putative epoxide hydrolase 1993434 8192194 METDI2114 Methylobacterium extorquens DM4 putative alpha/beta hydrolase, putative epoxide hydrolase YP_003067666.1 1992550 D 661410 CDS YP_003067667.1 254560572 8192195 1993730..1995811 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1995811 8192195 METDI2115 Methylobacterium extorquens DM4 hypothetical protein YP_003067667.1 1993730 D 661410 CDS YP_003067668.1 254560573 8192196 complement(1995846..1999157) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative sensor hybrid histidine kinase with multiple PAS and response regulator receiver domains 1999157 8192196 METDI2116 Methylobacterium extorquens DM4 putative sensor hybrid histidine kinase with multiple PAS and response regulator receiver domains YP_003067668.1 1995846 R 661410 CDS YP_003067669.1 254560574 8192197 complement(1999280..2000221) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2000221 8192197 METDI2117 Methylobacterium extorquens DM4 hypothetical protein YP_003067669.1 1999280 R 661410 CDS YP_003067670.1 254560575 8192198 2000410..2001219 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcriptional regulator (AraC family) 2001219 8192198 METDI2118 Methylobacterium extorquens DM4 putative transcriptional regulator (AraC family) YP_003067670.1 2000410 D 661410 CDS YP_003067671.1 254560576 8192199 complement(2001275..2003365) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2003365 8192199 METDI2119 Methylobacterium extorquens DM4 hypothetical protein YP_003067671.1 2001275 R 661410 CDS YP_003067672.1 254560577 8192200 complement(2003556..2006393) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2006393 8192200 METDI2120 Methylobacterium extorquens DM4 hypothetical protein YP_003067672.1 2003556 R 661410 CDS YP_003067673.1 254560578 8192201 complement(2006407..2007321) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2007321 8192201 METDI2121 Methylobacterium extorquens DM4 hypothetical protein YP_003067673.1 2006407 R 661410 CDS YP_003067674.1 254560579 8192202 complement(2007333..2008343) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16677824; Product type pe : putative enzyme; putative ATPase, MoxR-like protein 2008343 8192202 METDI2122 Methylobacterium extorquens DM4 putative ATPase, MoxR-like protein YP_003067674.1 2007333 R 661410 CDS YP_003067675.1 254560580 8192203 2008540..2008974 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2008974 8192203 METDI2123 Methylobacterium extorquens DM4 hypothetical protein YP_003067675.1 2008540 D 661410 CDS YP_003067676.1 254560581 8192204 2008971..2009552 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2009552 8192204 METDI2124 Methylobacterium extorquens DM4 hypothetical protein YP_003067676.1 2008971 D 661410 CDS YP_003067677.1 254560582 8192205 2009549..2010229 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2010229 8192205 METDI2125 Methylobacterium extorquens DM4 hypothetical protein YP_003067677.1 2009549 D 661410 CDS YP_003067678.1 254560583 8192206 2010298..2010555 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2010555 8192206 METDI2126 Methylobacterium extorquens DM4 hypothetical protein YP_003067678.1 2010298 D 661410 CDS YP_003067679.1 254560584 8192207 2010552..2011826 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative nucleotidyl transferase/polymerase 2011826 8192207 METDI2127 Methylobacterium extorquens DM4 putative nucleotidyl transferase/polymerase YP_003067679.1 2010552 D 661410 CDS YP_003067680.1 254560585 8192208 complement(2011924..2012325) 1 NC_012988.1 part of catalytic core of ATP synthase; alpha(3)beta(3)gamma(1)delta(1)epsilon(1); involved in producing ATP from ADP in the presence of the proton motive force across the membrane; F0F1 ATP synthase subunit epsilon 2012325 atpC 8192208 atpC Methylobacterium extorquens DM4 F0F1 ATP synthase subunit epsilon YP_003067680.1 2011924 R 661410 CDS YP_003067681.1 254560586 8195118 complement(2012352..2012603) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2012603 8195118 METDI2129 Methylobacterium extorquens DM4 hypothetical protein YP_003067681.1 2012352 R 661410 CDS YP_003067682.1 254560587 8192209 complement(2012727..2014184) 1 NC_012988.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The beta chain is a regulatory subunit; F0F1 ATP synthase subunit beta 2014184 atpD 8192209 atpD Methylobacterium extorquens DM4 F0F1 ATP synthase subunit beta YP_003067682.1 2012727 R 661410 CDS YP_003067683.1 254560588 8195119 complement(2014209..2015099) 1 NC_012988.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is a regulatory subunit; F0F1 ATP synthase subunit gamma 2015099 atpG 8195119 atpG Methylobacterium extorquens DM4 F0F1 ATP synthase subunit gamma YP_003067683.1 2014209 R 661410 CDS YP_003067684.1 254560589 8195121 complement(2015267..2016796) 1 NC_012988.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the alpha chain is a catalytic subunit; F0F1 ATP synthase subunit alpha 2016796 atpA 8195121 atpA Methylobacterium extorquens DM4 F0F1 ATP synthase subunit alpha YP_003067684.1 2015267 R 661410 CDS YP_003067685.1 254560590 8195116 complement(2016871..2017440) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative ATP synthase delta chain (atpH) 2017440 8195116 METDI2133 Methylobacterium extorquens DM4 putative ATP synthase delta chain (atpH) YP_003067685.1 2016871 R 661410 CDS YP_003067686.1 254560591 8192210 complement(2017709..2018779) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 11743193, 11743194; Product type e : enzyme; Ferrochelatase (Protoheme ferro-lyase) (Heme synthetase) 2018779 hemH 8192210 hemH Methylobacterium extorquens DM4 Ferrochelatase (Protoheme ferro-lyase) (Heme synthetase) YP_003067686.1 2017709 R 661410 CDS YP_003067687.1 254560592 8195553 2018971..2019942 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative S-adenosyl-L-methionine-dependent methyltransferase 2019942 8195553 METDI2135 Methylobacterium extorquens DM4 putative S-adenosyl-L-methionine-dependent methyltransferase YP_003067687.1 2018971 D 661410 CDS YP_003067688.1 254560593 8192211 2019950..2021467 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative 5'-nucleotidase , 2'3'-cyclic-nucleotide 2'-phosphodiesterase 2021467 8192211 METDI2136 Methylobacterium extorquens DM4 putative 5'-nucleotidase , 2'3'-cyclic-nucleotide 2'-phosphodiesterase YP_003067688.1 2019950 D 661410 CDS YP_003067689.1 254560594 8192212 2021635..2022339 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 10984043; Product type e : enzyme; Uracil-DNA glycosylase (UDG) 2022339 ung 8192212 ung Methylobacterium extorquens DM4 Uracil-DNA glycosylase (UDG) YP_003067689.1 2021635 D 661410 CDS YP_003067690.1 254560595 8196303 2022571..2023401 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 12471500; hypothetical protein 2023401 8196303 METDI2138 Methylobacterium extorquens DM4 hypothetical protein YP_003067690.1 2022571 D 661410 CDS YP_003067691.1 254560596 8192213 2023404..2024807 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12471500, 2152903; Product type pt : putative transporter; putative chromate transport protein ChrA; putative membrane protein 2024807 8192213 METDI2139 Methylobacterium extorquens DM4 putative chromate transport protein ChrA; putative membrane protein YP_003067691.1 2023404 D 661410 CDS YP_003067692.1 254560597 8192214 complement(2024950..2025147) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2025147 8192214 METDI2140 Methylobacterium extorquens DM4 hypothetical protein YP_003067692.1 2024950 R 661410 CDS YP_003067693.1 254560598 8192215 complement(2025281..2026183) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8525063; Product type pf : putative factor; putative cell-binding factor 2 precursor (Major antigen peb4A), cbf2 2026183 8192215 METDI2141 Methylobacterium extorquens DM4 putative cell-binding factor 2 precursor (Major antigen peb4A), cbf2 YP_003067693.1 2025281 R 661410 CDS YP_003067694.1 254560599 8192216 2026658..2029570 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type t : transporter; preprotein translocase subunit, ATPase 2029570 secA 8192216 secA Methylobacterium extorquens DM4 preprotein translocase subunit, ATPase YP_003067694.1 2026658 D 661410 CDS YP_003067695.1 254560600 8196105 complement(2029733..2030896) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 10595535, 6795623, 7041115, 92212899, 97464439, 9819201, 99421326; Product type e : enzyme; beta-lactamase 2030896 ampC 8196105 ampC Methylobacterium extorquens DM4 beta-lactamase YP_003067695.1 2029733 R 661410 CDS YP_003067696.1 254560601 8195073 2031053..2031934 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2031934 8195073 METDI2144 Methylobacterium extorquens DM4 hypothetical protein YP_003067696.1 2031053 D 661410 CDS YP_003067697.1 254560602 8192217 2031931..2032386 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 9371440; Product type pe : putative enzyme; putative hydrolase, Nudix domain 2032386 8192217 METDI2145 Methylobacterium extorquens DM4 putative hydrolase, Nudix domain YP_003067697.1 2031931 D 661410 CDS YP_003067698.1 254560603 8192218 complement(2032421..2033677) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative Poly(3-hydroxybutyrate) depolymerase 2033677 8192218 METDI2146 Methylobacterium extorquens DM4 putative Poly(3-hydroxybutyrate) depolymerase YP_003067698.1 2032421 R 661410 CDS YP_003067699.1 254560604 8192219 complement(2033752..2034201) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2034201 8192219 METDI2147 Methylobacterium extorquens DM4 hypothetical protein YP_003067699.1 2033752 R 661410 CDS YP_003067700.1 254560605 8192220 complement(2034408..2035118) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 10217794; Product type e : enzyme; DNA polymerase III epsilon subunit 2035118 dnaQ 8192220 dnaQ Methylobacterium extorquens DM4 DNA polymerase III epsilon subunit YP_003067700.1 2034408 R 661410 CDS YP_003067701.1 254560606 8195310 complement(2035189..2035779) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; dephospho-CoA kinase (dephosphocoenzyme A kinase) 2035779 coaE 8195310 coaE Methylobacterium extorquens DM4 dephospho-CoA kinase (dephosphocoenzyme A kinase) YP_003067701.1 2035189 R 661410 CDS YP_003067702.1 254560607 8195180 complement(2035806..2036642) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10739937, 3277621; Product type pe : putative enzyme; putative shikimate 5-dehydrogenase (aroE) 2036642 8195180 METDI2150 Methylobacterium extorquens DM4 putative shikimate 5-dehydrogenase (aroE) YP_003067702.1 2035806 R 661410 CDS YP_003067703.1 254560608 8192221 complement(2036671..2037696) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10229265, 11443104, 15919996, 9696746; Product type pt : putative transporter; putative cation efflux system protein 2037696 8192221 METDI2151 Methylobacterium extorquens DM4 putative cation efflux system protein YP_003067703.1 2036671 R 661410 CDS YP_003067704.1 254560609 8192222 complement(2037711..2038325) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type cp : cell process; Maf-like protein 2038325 8192222 METDI2152 Methylobacterium extorquens DM4 Maf-like protein YP_003067704.1 2037711 R 661410 CDS YP_003067705.1 254560610 8192223 complement(2038342..2039478) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2039478 8192223 METDI2153 Methylobacterium extorquens DM4 hypothetical protein YP_003067705.1 2038342 R 661410 CDS YP_003067706.1 254560611 8192224 complement(2039490..2040320) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2040320 8192224 METDI2154 Methylobacterium extorquens DM4 hypothetical protein YP_003067706.1 2039490 R 661410 CDS YP_003067707.1 254560612 8192225 2041068..2042180 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type e : enzyme; uroporphyrinogen decarboxylase 2042180 hemE 8192225 hemE Methylobacterium extorquens DM4 uroporphyrinogen decarboxylase YP_003067707.1 2041068 D 661410 CDS YP_003067708.1 254560613 8195551 2042177..2042626 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative Nudix hydrolase family protein, putative pyrophosphohydrolase 2042626 8195551 METDI2156 Methylobacterium extorquens DM4 putative Nudix hydrolase family protein, putative pyrophosphohydrolase YP_003067708.1 2042177 D 661410 CDS YP_003067709.1 254560614 8192226 2042607..2043059 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2043059 8192226 METDI2157 Methylobacterium extorquens DM4 hypothetical protein YP_003067709.1 2042607 D 661410 CDS YP_003067710.1 254560615 8192227 2043146..2043487 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2043487 8192227 METDI2158 Methylobacterium extorquens DM4 hypothetical protein YP_003067710.1 2043146 D 661410 CDS YP_003067711.1 254560616 8192228 complement(2043636..2044613) 1 NC_012988.1 long form of enzyme; catalyzes the formation of N'-5'-phosphoribosyl-ATP from phosphoribosyl pyrophosphate; crucial role in histidine biosynthesis; forms active dimers and inactive hexamers which is dependent on concentration of substrates and inhibitors; ATP phosphoribosyltransferase 2044613 hisG 8192228 hisG Methylobacterium extorquens DM4 ATP phosphoribosyltransferase YP_003067711.1 2043636 R 661410 CDS YP_003067712.1 254560617 8195563 complement(2044610..2045788) 1 NC_012988.1 May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine; ATP phosphoribosyltransferase regulatory subunit 2045788 hisZ 8195563 hisZ Methylobacterium extorquens DM4 ATP phosphoribosyltransferase regulatory subunit YP_003067712.1 2044610 R 661410 CDS YP_003067713.1 254560618 8192229 complement(2045933..2046820) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative haloacid dehalogenase-like hydrolase, HAD-superfamily subfamily IIA hydrolase 2046820 8192229 METDI2161 Methylobacterium extorquens DM4 putative haloacid dehalogenase-like hydrolase, HAD-superfamily subfamily IIA hydrolase YP_003067713.1 2045933 R 661410 CDS YP_003067714.1 254560619 8192230 complement(2046941..2047453) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2047453 8192230 METDI2162 Methylobacterium extorquens DM4 hypothetical protein YP_003067714.1 2046941 R 661410 CDS YP_003067715.1 254560620 8192231 2047759..2051175 1 NC_012988.1 Synthesizes thioester adducts of fatty acids enzymatically to the phosphopantetheine group of acyl carrier protein; acylglycerophosphoethanolamine acyltransferase 2051175 8192231 METDI2163 Methylobacterium extorquens DM4 acylglycerophosphoethanolamine acyltransferase YP_003067715.1 2047759 D 661410 CDS YP_003067716.1 254560621 8192232 2051452..2051721 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2051721 8192232 METDI2164 Methylobacterium extorquens DM4 hypothetical protein YP_003067716.1 2051452 D 661410 CDS YP_003067717.1 254560622 8192233 2051765..2052028 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type pr : putative regulator; DNA-binding protein 2052028 pgpC 8192233 pgpC Methylobacterium extorquens DM4 DNA-binding protein YP_003067717.1 2051765 D 661410 CDS YP_003067718.1 254560623 8195852 2052175..2052861 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2052861 8195852 METDI2166 Methylobacterium extorquens DM4 hypothetical protein YP_003067718.1 2052175 D 661410 CDS YP_003067719.1 254560624 8192234 complement(2052883..2053875) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2053875 8192234 METDI2167 Methylobacterium extorquens DM4 hypothetical protein YP_003067719.1 2052883 R 661410 CDS YP_003067720.1 254560625 8192235 complement(2053936..2054958) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2054958 8192235 METDI2168 Methylobacterium extorquens DM4 hypothetical protein YP_003067720.1 2053936 R 661410 CDS YP_003067721.1 254560626 8192236 2055118..2055570 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 11135669, 12571227, 8514782, 93368423; Product type e : enzyme; molybdopterin synthase, large subunit 2055570 moaE 8192236 moaE Methylobacterium extorquens DM4 molybdopterin synthase, large subunit YP_003067721.1 2055118 D 661410 CDS YP_003067722.1 254560627 8195706 2055663..2056835 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2056835 8195706 METDI2170 Methylobacterium extorquens DM4 hypothetical protein YP_003067722.1 2055663 D 661410 CDS YP_003067723.1 254560628 8192237 complement(2056873..2058525) 1 NC_012988.1 malate dehydrogenase; catalyzes the oxidation of malate to oxaloacetate; malate:quinone oxidoreductase 2058525 mqo 8192237 mqo Methylobacterium extorquens DM4 malate:quinone oxidoreductase YP_003067723.1 2056873 R 661410 CDS YP_003067724.1 254560629 8195721 complement(2058871..2060034) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2060034 8195721 METDI2172 Methylobacterium extorquens DM4 hypothetical protein YP_003067724.1 2058871 R 661410 CDS YP_003067725.1 254560630 8192238 complement(2060031..2062364) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2062364 8192238 METDI2173 Methylobacterium extorquens DM4 hypothetical protein YP_003067725.1 2060031 R 661410 CDS YP_003067726.1 254560631 8192239 complement(2062361..2063461) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative ABC superfamily protein 2063461 yehL 8192239 yehL Methylobacterium extorquens DM4 putative ABC superfamily protein YP_003067726.1 2062361 R 661410 CDS YP_003067727.1 254560632 8196359 complement(2063458..2065041) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2065041 8196359 METDI2175 Methylobacterium extorquens DM4 hypothetical protein YP_003067727.1 2063458 R 661410 CDS YP_003067728.1 254560633 8192240 complement(2065041..2066408) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2066408 8192240 METDI2176 Methylobacterium extorquens DM4 hypothetical protein YP_003067728.1 2065041 R 661410 CDS YP_003067729.1 254560634 8192241 complement(2066604..2068106) 1 NC_012988.1 catalyzes the formation of D-glucono-1,5-lactone 6-phosphate from D-glucose 6-phosphate; glucose-6-phosphate 1-dehydrogenase 2068106 zwf 8192241 zwf Methylobacterium extorquens DM4 glucose-6-phosphate 1-dehydrogenase YP_003067729.1 2066604 R 661410 CDS YP_003067730.1 254560635 8196382 2068240..2068488 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2068488 8196382 METDI2178 Methylobacterium extorquens DM4 hypothetical protein YP_003067730.1 2068240 D 661410 CDS YP_003067731.1 254560636 8192242 2068485..2068775 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2068775 8192242 METDI2179 Methylobacterium extorquens DM4 hypothetical protein YP_003067731.1 2068485 D 661410 CDS YP_003067732.1 254560637 8192243 2068857..2069495 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2069495 8192243 METDI2180 Methylobacterium extorquens DM4 hypothetical protein YP_003067732.1 2068857 D 661410 CDS YP_003067733.1 254560638 8192246 2071458..2072156 1 NC_012988.1 type 1 subfamily; involved in last step of pyrimidine biosynthesis; converts orotidine 5'-phosphate to UMP and carbon dioxide; OMP decarboxylase; OMPDCase; OMPdecase; orotidine 5'-phosphate decarboxylase 2072156 pyrF 8192246 pyrF Methylobacterium extorquens DM4 orotidine 5'-phosphate decarboxylase YP_003067733.1 2071458 D 661410 CDS YP_003067734.1 254560639 8195951 2072159..2072503 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2072503 8195951 METDI2184 Methylobacterium extorquens DM4 hypothetical protein YP_003067734.1 2072159 D 661410 CDS YP_003067735.1 254560640 8192247 complement(2072523..2073146) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcriptional regulator, TetR family 2073146 8192247 METDI2185 Methylobacterium extorquens DM4 putative transcriptional regulator, TetR family YP_003067735.1 2072523 R 661410 CDS YP_003067736.1 254560641 8192248 complement(2073369..2073569) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2073569 8192248 METDI2186 Methylobacterium extorquens DM4 hypothetical protein YP_003067736.1 2073369 R 661410 CDS YP_003067737.1 254560642 8192249 complement(2073772..2074278) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; deoxyuridine 5'-triphosphate nucleotidohydrolase 2074278 dut 8192249 dut Methylobacterium extorquens DM4 deoxyuridine 5'-triphosphate nucleotidohydrolase YP_003067737.1 2073772 R 661410 CDS YP_003067738.1 254560643 8195319 2074375..2075148 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2075148 8195319 METDI2188 Methylobacterium extorquens DM4 hypothetical protein YP_003067738.1 2074375 D 661410 CDS YP_003067739.1 254560644 8192250 2075153..2075686 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative mutator protein MutT/NUDIX-family hydrolase 2075686 8192250 METDI2189 Methylobacterium extorquens DM4 putative mutator protein MutT/NUDIX-family hydrolase YP_003067739.1 2075153 D 661410 CDS YP_003067740.1 254560645 8192251 2075913..2076599 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16926146; Product type pe : putative enzyme; putative carbonic anhydrase domain 2076599 8192251 METDI2190 Methylobacterium extorquens DM4 putative carbonic anhydrase domain YP_003067740.1 2075913 D 661410 CDS YP_003067741.1 254560646 8192252 complement(2076818..2077741) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 1729235; Product type pe : putative enzyme; putative CysQ protein (PAPS (adenosine 3'-phosphate 5'-phosphosulfate) 3'(2'),5'-bisphosphate nucleotidase) 2077741 8192252 METDI2191 Methylobacterium extorquens DM4 putative CysQ protein (PAPS (adenosine 3'-phosphate 5'-phosphosulfate) 3'(2'),5'-bisphosphate nucleotidase) YP_003067741.1 2076818 R 661410 CDS YP_003067742.1 254560647 8192253 complement(2077752..2077967) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2077967 8192253 METDI2192 Methylobacterium extorquens DM4 hypothetical protein YP_003067742.1 2077752 R 661410 CDS YP_003067743.1 254560648 8192254 2078096..2078836 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2078836 8192254 METDI2193 Methylobacterium extorquens DM4 hypothetical protein YP_003067743.1 2078096 D 661410 CDS YP_003067744.1 254560649 8192255 2079014..2081764 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; signal transduction histidine kinase with N-terminal phosphotransfer, CheW-like and C-terminal response regulator receiver domains 2081764 8192255 METDI2194 Methylobacterium extorquens DM4 signal transduction histidine kinase with N-terminal phosphotransfer, CheW-like and C-terminal response regulator receiver domains YP_003067744.1 2079014 D 661410 CDS YP_003067745.1 254560650 8192256 2081797..2082276 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 11934495; Product type r : regulator; Chemotaxis signal transduction/oligomerization protein 2082276 cheW 8192256 cheW Methylobacterium extorquens DM4 Chemotaxis signal transduction/oligomerization protein YP_003067745.1 2081797 D 661410 CDS YP_003067746.1 254560651 8195165 2082297..2082719 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type r : regulator; Chemotaxis response regulator receiver 2082719 cheY 8195165 cheY Methylobacterium extorquens DM4 Chemotaxis response regulator receiver YP_003067746.1 2082297 D 661410 CDS YP_003067747.1 254560652 8195166 2082786..2083934 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 3280143, 3510184, 89053899, 90008896, 93209955, 9687492, 99395068; Product type r : regulator; Chemotaxis response regulator protein-glutamate methylesterase 2083934 cheB 8195166 cheB Methylobacterium extorquens DM4 Chemotaxis response regulator protein-glutamate methylesterase YP_003067747.1 2082786 D 661410 CDS YP_003067748.1 254560653 8195162 2083934..2084791 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 11934495; Product type r : regulator; glutamate methyltransferase, chemotactic response regulator 2084791 cheR 8195162 cheR Methylobacterium extorquens DM4 glutamate methyltransferase, chemotactic response regulator YP_003067748.1 2083934 D 661410 CDS YP_003067749.1 254560654 8195164 2084838..2085563 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative amidolyase/hydrolase/carboxylase subunit 2085563 8195164 METDI2199 Methylobacterium extorquens DM4 putative amidolyase/hydrolase/carboxylase subunit YP_003067749.1 2084838 D 661410 CDS YP_003067750.1 254560655 8192257 2085560..2086579 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative amidolyase/hydrolase/carboxylase subunit 2086579 8192257 METDI2200 Methylobacterium extorquens DM4 putative amidolyase/hydrolase/carboxylase subunit YP_003067750.1 2085560 D 661410 CDS YP_003067751.1 254560656 8192258 2086625..2087719 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8614629; Product type pe : putative enzyme; putative UV damage endonuclease 2087719 8192258 METDI2201 Methylobacterium extorquens DM4 putative UV damage endonuclease YP_003067751.1 2086625 D 661410 CDS YP_003067752.1 254560657 8192259 2087840..2090557 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2090557 8192259 METDI2202 Methylobacterium extorquens DM4 hypothetical protein YP_003067752.1 2087840 D 661410 CDS YP_003067753.1 254560658 8192260 2090733..2090918 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2090918 8192260 METDI2203 Methylobacterium extorquens DM4 hypothetical protein YP_003067753.1 2090733 D 661410 CDS YP_003067754.1 254560659 8192261 complement(2090949..2091389) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 16926146; hypothetical protein 2091389 8192261 METDI2204 Methylobacterium extorquens DM4 hypothetical protein YP_003067754.1 2090949 R 661410 CDS YP_003067755.1 254560660 8192262 2091705..2092343 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2092343 8192262 METDI2205 Methylobacterium extorquens DM4 hypothetical protein YP_003067755.1 2091705 D 661410 CDS YP_003067756.1 254560661 8192263 2092464..2093036 1 NC_012988.1 Evidence 1c : Function experimentally demonstrated in the studied genus; PubMedId : 12511515, 14734568; Product type e : enzyme; cobalamin adenosyltransferase, methylmalonyl-CoA mutase cofactor biosynthesis protein 2093036 meaD 8192263 meaD Methylobacterium extorquens DM4 cobalamin adenosyltransferase, methylmalonyl-CoA mutase cofactor biosynthesis protein YP_003067756.1 2092464 D 661410 CDS YP_003067757.1 254560662 8195678 2093199..2093948 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; Electron transfer flavoprotein subunit beta (Beta-ETF) (Electron transfer flavoprotein small subunit) (ETFSS) 2093948 etfB 8195678 etfB Methylobacterium extorquens DM4 Electron transfer flavoprotein subunit beta (Beta-ETF) (Electron transfer flavoprotein small subunit) (ETFSS) YP_003067757.1 2093199 D 661410 CDS YP_003067758.1 254560663 8195335 2094029..2094982 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 15188393, 16926146, 8599534; Product type e : enzyme; electron transfer flavoprotein, NAD/FAD-binding domain and ETFP adenine nucleotide-binding domain-like 2094982 etfA 8195335 etfA Methylobacterium extorquens DM4 electron transfer flavoprotein, NAD/FAD-binding domain and ETFP adenine nucleotide-binding domain-like YP_003067758.1 2094029 D 661410 CDS YP_003067759.1 254560664 8195334 2095141..2096022 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 2687255, 8655474; Product type e : enzyme; 3-hydroxybutyryl-CoA dehydrogenase 2096022 hbdA 8195334 hbdA Methylobacterium extorquens DM4 3-hydroxybutyryl-CoA dehydrogenase YP_003067759.1 2095141 D 661410 CDS YP_003067760.1 254560665 8195546 complement(2096158..2096436) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2096436 8195546 METDI2210 Methylobacterium extorquens DM4 hypothetical protein YP_003067760.1 2096158 R 661410 CDS YP_003067761.1 254560666 8192264 complement(2096628..2097638) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative NADPH quinone oxidoreductase 2097638 8192264 METDI2211 Methylobacterium extorquens DM4 putative NADPH quinone oxidoreductase YP_003067761.1 2096628 R 661410 CDS YP_003067762.1 254560667 8192265 complement(2097635..2097889) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 16208464; hypothetical protein 2097889 8192265 METDI2212 Methylobacterium extorquens DM4 hypothetical protein YP_003067762.1 2097635 R 661410 CDS YP_003067763.1 254560668 8192266 complement(2097993..2098643) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 12037295; Product type e : enzyme; uracil phosphoribosyltransferase 2098643 upp 8192266 upp Methylobacterium extorquens DM4 uracil phosphoribosyltransferase YP_003067763.1 2097993 R 661410 CDS YP_003067764.1 254560669 8196305 complement(2098740..2100833) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 2975249, 8980629; Product type e : enzyme; glycosyl hydrolase (Debranching enzyme) 2100833 glgX 8196305 glgX Methylobacterium extorquens DM4 glycosyl hydrolase (Debranching enzyme) YP_003067764.1 2098740 R 661410 CDS YP_003067765.1 254560670 8195492 complement(2100916..2102340) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 16052332, 17209814; Product type e : enzyme; alpha,alpha-trehalose-phosphate synthase (UDP-forming); osmoregulatory trehalose synthesis protein A 2102340 otsA 8195492 otsA Methylobacterium extorquens DM4 alpha,alpha-trehalose-phosphate synthase (UDP-forming); osmoregulatory trehalose synthesis protein A YP_003067765.1 2100916 R 661410 CDS YP_003067766.1 254560671 8195814 2102871..2103350 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 11097914; hypothetical protein 2103350 8195814 METDI2216 Methylobacterium extorquens DM4 hypothetical protein YP_003067766.1 2102871 D 661410 CDS YP_003067767.1 254560672 8192267 2103347..2103769 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2103769 8192267 METDI2217 Methylobacterium extorquens DM4 hypothetical protein YP_003067767.1 2103347 D 661410 CDS YP_003067768.1 254560673 8192268 2103766..2104152 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2104152 8192268 METDI2218 Methylobacterium extorquens DM4 hypothetical protein YP_003067768.1 2103766 D 661410 CDS YP_003067769.1 254560674 8192269 2104217..2105053 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; PubMedId : 16926146; hypothetical protein 2105053 8192269 METDI2219 Methylobacterium extorquens DM4 hypothetical protein YP_003067769.1 2104217 D 661410 CDS YP_003067770.1 254560675 8192270 complement(2105133..2106644) 1 NC_012988.1 catalyzes a two-step reaction, first charging a histidine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class II aminoacyl-tRNA synthetase; forms homodimers; some organisms have a paralogous gene, hisZ, that is similar to hisS and produces a protein that performs the first step in histidine biosynthesis along with HisG; histidyl-tRNA synthetase 2106644 hisS 8192270 hisS Methylobacterium extorquens DM4 histidyl-tRNA synthetase YP_003067770.1 2105133 R 661410 CDS YP_003067771.1 254560676 8195566 complement(2106728..2107099) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 1435734; Product type f : factor; Secretion chaperone protein 2107099 csaA 8195566 csaA Methylobacterium extorquens DM4 Secretion chaperone protein YP_003067771.1 2106728 R 661410 CDS YP_003067772.1 254560677 8195221 complement(2107198..2107716) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2107716 8195221 METDI2222 Methylobacterium extorquens DM4 hypothetical protein YP_003067772.1 2107198 R 661410 CDS YP_003067773.1 254560678 8192271 complement(2107783..2109036) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative transporter, major facilitator family 2109036 8192271 METDI2223 Methylobacterium extorquens DM4 putative transporter, major facilitator family YP_003067773.1 2107783 R 661410 CDS YP_003067774.1 254560679 8192272 complement(2109325..2109831) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 12475171, 14643199, 15128935, 21194699, 90361704, 91004235, 93304177, 9564; Product type f : factor; protein-export protein SecB 2109831 secB 8192272 secB Methylobacterium extorquens DM4 protein-export protein SecB YP_003067774.1 2109325 R 661410 CDS YP_003067775.1 254560680 8196106 2110293..2111012 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2111012 8196106 METDI2225 Methylobacterium extorquens DM4 hypothetical protein YP_003067775.1 2110293 D 661410 CDS YP_003067776.1 254560681 8192273 2111025..2112296 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative membrane-bound lytic murein transglycosylase 2112296 8192273 METDI2226 Methylobacterium extorquens DM4 putative membrane-bound lytic murein transglycosylase YP_003067776.1 2111025 D 661410 CDS YP_003067777.1 254560682 8192274 2112293..2113078 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor; putative Smr protein/MutS2 C-terminal, damaged DNA binding, mismatch repair 2113078 8192274 METDI2227 Methylobacterium extorquens DM4 putative Smr protein/MutS2 C-terminal, damaged DNA binding, mismatch repair YP_003067777.1 2112293 D 661410 CDS YP_003067778.1 254560683 8192275 2113331..2114674 1 NC_012988.1 An RNA-DNA helicase that actively releases nascent mRNAs from paused transcription complexes; transcription termination factor Rho 2114674 rho 8192275 rho Methylobacterium extorquens DM4 transcription termination factor Rho YP_003067778.1 2113331 D 661410 CDS YP_003067779.1 254560684 8195991 2114948..2116681 1 NC_012988.1 catalyzes the formation of acetate from pyruvate; pyruvate dehydrogenase 2116681 poxB 8195991 poxB Methylobacterium extorquens DM4 pyruvate dehydrogenase YP_003067779.1 2114948 D 661410 CDS YP_003067780.1 254560685 8195879 complement(2116794..2117714) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2117714 8195879 METDI2230 Methylobacterium extorquens DM4 hypothetical protein YP_003067780.1 2116794 R 661410 CDS YP_003067781.1 254560686 8192276 complement(2118021..2118767) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type m : membrane component; Membrane protein, TerC family 2118767 8192276 METDI2231 Methylobacterium extorquens DM4 Membrane protein, TerC family YP_003067781.1 2118021 R 661410 CDS YP_003067782.1 254560687 8192277 complement(2118784..2119713) 1 NC_012988.1 similar to YegS from E. coli; putative lipid kinase 2119713 8192277 METDI2232 Methylobacterium extorquens DM4 putative lipid kinase YP_003067782.1 2118784 R 661410 CDS YP_003067783.1 254560688 8192278 2120278..2121093 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2121093 8192278 METDI2233 Methylobacterium extorquens DM4 hypothetical protein YP_003067783.1 2120278 D 661410 CDS YP_003067784.1 254560689 8192279 2121230..2122540 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2122540 8192279 METDI2234 Methylobacterium extorquens DM4 hypothetical protein YP_003067784.1 2121230 D 661410 CDS YP_003067785.1 254560690 8192280 complement(2122571..2123449) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative acid phosphatase 2123449 8192280 METDI2235 Methylobacterium extorquens DM4 putative acid phosphatase YP_003067785.1 2122571 R 661410 CDS YP_003067786.1 254560691 8192281 complement(2123615..2124505) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2124505 8192281 METDI2236 Methylobacterium extorquens DM4 hypothetical protein YP_003067786.1 2123615 R 661410 CDS YP_003067787.1 254560692 8192282 complement(2124502..2124798) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; DNA-binding protein, putative transcriptional regulator 2124798 8192282 METDI2237 Methylobacterium extorquens DM4 DNA-binding protein, putative transcriptional regulator YP_003067787.1 2124502 R 661410 CDS YP_003067788.1 254560693 8192283 complement(2124829..2125209) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2125209 8192283 METDI2238 Methylobacterium extorquens DM4 hypothetical protein YP_003067788.1 2124829 R 661410 CDS YP_003067789.1 254560694 8192284 complement(2125266..2126108) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 9012664; Product type e : enzyme; 2,3,4,5-tetrahydropyridine-2-carboxylate N-succinyltransferase 2126108 dapD 8192284 dapD Methylobacterium extorquens DM4 2,3,4,5-tetrahydropyridine-2-carboxylate N-succinyltransferase YP_003067789.1 2125266 R 661410 CDS YP_003067790.1 254560695 8195272 complement(2126271..2126738) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative cyclic nucleotide binding protein 2126738 8195272 METDI2240 Methylobacterium extorquens DM4 putative cyclic nucleotide binding protein YP_003067790.1 2126271 R 661410 CDS YP_003067791.1 254560696 8192285 complement(2126925..2127611) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8655513; Product type pr : putative regulator; putative two-component transcriptional regulator, winged helix family 2127611 8192285 METDI2241 Methylobacterium extorquens DM4 putative two-component transcriptional regulator, winged helix family YP_003067791.1 2126925 R 661410 CDS YP_003067792.1 254560697 8192286 2127902..2128495 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2128495 8192286 METDI2242 Methylobacterium extorquens DM4 hypothetical protein YP_003067792.1 2127902 D 661410 CDS YP_003067793.1 254560698 8192287 complement(2128535..2129275) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative enzyme with PLP-binding domain, putative alanine racemase 2129275 8192287 METDI2243 Methylobacterium extorquens DM4 putative enzyme with PLP-binding domain, putative alanine racemase YP_003067793.1 2128535 R 661410 CDS YP_003067794.1 254560699 8192288 2129587..2132214 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; leucine tRNA synthetase 2132214 leuS 8192288 leuS Methylobacterium extorquens DM4 leucine tRNA synthetase YP_003067794.1 2129587 D 661410 CDS YP_003067795.1 254560700 8195632 2132305..2133639 1 NC_012988.1 in Escherichia coli this protein is involved in the biosynthesis of the hypermodified nucleoside 5-methylaminomethyl-2-thiouridine, which is found in the wobble position of some tRNAs and affects ribosomal frameshifting; shows potassium-dependent dimerization and GTP hydrolysis; also involved in regulation of glutamate-dependent acid resistance and activation of gadE; tRNA modification GTPase TrmE 2133639 trmE 8195632 trmE Methylobacterium extorquens DM4 tRNA modification GTPase TrmE YP_003067795.1 2132305 D 661410 CDS YP_003067796.1 254560701 8196212 complement(2133653..2134675) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2134675 8196212 METDI2246 Methylobacterium extorquens DM4 hypothetical protein YP_003067796.1 2133653 R 661410 CDS YP_003067797.1 254560702 8192289 2135043..2135309 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2135309 8192289 METDI2247 Methylobacterium extorquens DM4 hypothetical protein YP_003067797.1 2135043 D 661410 CDS YP_003067798.1 254560703 8192290 2135483..2137357 1 NC_012988.1 GidA; glucose-inhibited cell division protein A; involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U) of the wobble uridine base in some tRNAs; tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA 2137357 gidA 8192290 gidA Methylobacterium extorquens DM4 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA YP_003067798.1 2135483 D 661410 CDS YP_003067799.1 254560704 8195484 2137323..2138027 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 12597275; Product type e : enzyme; Methyltransferase gidB (Glucose-inhibited division protein B) 2138027 gidB 8195484 gidB Methylobacterium extorquens DM4 Methyltransferase gidB (Glucose-inhibited division protein B) YP_003067799.1 2137323 D 661410 CDS YP_003067800.1 254560705 8195485 2138024..2138884 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 12603730, 9054507; Product type e : enzyme; chromosome partitioning protein, ATP-binding, nucleotide-binding 2138884 parA 8195485 parA Methylobacterium extorquens DM4 chromosome partitioning protein, ATP-binding, nucleotide-binding YP_003067800.1 2138024 D 661410 CDS YP_003067801.1 254560706 8195826 2138918..2139814 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type f : factor; chromosome-partitioning protein parB 2139814 parB 8195826 parB Methylobacterium extorquens DM4 chromosome-partitioning protein parB YP_003067801.1 2138918 D 661410 CDS YP_003067802.1 254560707 8195827 complement(2139879..2140910) 1 NC_012988.1 required for the assembly and function of the DNAX complex which are required for the assembly of the beta subunit onto primed DNA; DNA polymerase III subunit delta 2140910 holA 8195827 holA Methylobacterium extorquens DM4 DNA polymerase III subunit delta YP_003067802.1 2139879 R 661410 CDS YP_003067803.1 254560708 8192291 complement(2140921..2141469) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2141469 8192291 METDI2253 Methylobacterium extorquens DM4 hypothetical protein YP_003067803.1 2140921 R 661410 CDS YP_003067804.1 254560709 8192292 2141873..2142217 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2142217 8192292 METDI2254 Methylobacterium extorquens DM4 hypothetical protein YP_003067804.1 2141873 D 661410 CDS YP_003067805.1 254560710 8192293 2142350..2143453 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2143453 8192293 METDI2255 Methylobacterium extorquens DM4 hypothetical protein YP_003067805.1 2142350 D 661410 CDS YP_003067806.1 254560711 8192294 complement(2143460..2144404) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2144404 8192294 METDI2256 Methylobacterium extorquens DM4 hypothetical protein YP_003067806.1 2143460 R 661410 CDS YP_003067807.1 254560712 8192295 complement(2144422..2145360) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 7916685; Product type pe : putative enzyme; putative cyclohexadienyl dehydrogenase (tyrC-like) 2145360 8192295 METDI2257 Methylobacterium extorquens DM4 putative cyclohexadienyl dehydrogenase (tyrC-like) YP_003067807.1 2144422 R 661410 CDS YP_003067808.1 254560713 8192296 complement(2145357..2146475) 1 NC_012988.1 catalyzes the formation of L-histidinol phosphate from imidazole-acetol phosphate and glutamate in histidine biosynthesis; histidinol-phosphate aminotransferase 2146475 hisC 8192296 hisC Methylobacterium extorquens DM4 histidinol-phosphate aminotransferase YP_003067808.1 2145357 R 661410 CDS YP_003067809.1 254560714 8195559 complement(2146590..2147087) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2147087 8195559 METDI2259 Methylobacterium extorquens DM4 hypothetical protein YP_003067809.1 2146590 R 661410 CDS YP_003067810.1 254560715 8192297 complement(2147234..2149468) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type prc : putative receptor; putative TonB-dependent siderophore receptor (putative ferrichrome outer membrane transporter) 2149468 8192297 METDI2260 Methylobacterium extorquens DM4 putative TonB-dependent siderophore receptor (putative ferrichrome outer membrane transporter) YP_003067810.1 2147234 R 661410 CDS YP_003067811.1 254560716 8192298 complement(2149740..2151746) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 89197799, 94042856, 99229748; Product type t : transporter; potassium uptake protein Kup 2151746 trkD 8192298 trkD Methylobacterium extorquens DM4 potassium uptake protein Kup YP_003067811.1 2149740 R 661410 CDS YP_003067812.1 254560717 8196209 complement(2152065..2153384) 1 NC_012988.1 catalyzes the conversion of 2C-methyl-D-erythritol 2,4-cyclodiphosphate into 4-hydroxy-3-methyl-2-en-1-yl diphosphate; involved in isoprenoid synthesis; 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase 2153384 ispG 8196209 ispG Methylobacterium extorquens DM4 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase YP_003067812.1 2152065 R 661410 CDS YP_003067813.1 254560718 8195474 2153725..2154969 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; hypothetical protein 2154969 8195474 METDI2264 Methylobacterium extorquens DM4 hypothetical protein YP_003067813.1 2153725 D 661410 CDS YP_003067814.1 254560719 8192299 2155061..2156113 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2156113 8192299 METDI2265 Methylobacterium extorquens DM4 hypothetical protein YP_003067814.1 2155061 D 661410 CDS YP_003067815.1 254560720 8192300 2156213..2157145 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 10201405, 6356036; Product type e : enzyme; 5,10-methylenetetrahydrofolate reductase 2157145 metF 8192300 metF Methylobacterium extorquens DM4 5,10-methylenetetrahydrofolate reductase YP_003067815.1 2156213 D 661410 CDS YP_003067816.1 254560721 8195682 2157345..2161097 1 NC_012988.1 one of two methionine synthases in Escherichia coli; MetH catalyzes a methyl transfer reaction from methyltetrahydrofolate to homocysteine to create methionine; requires zinc for activity; B12-dependent methionine synthase 2161097 metH 8195682 metH Methylobacterium extorquens DM4 B12-dependent methionine synthase YP_003067816.1 2157345 D 661410 CDS YP_003067817.1 254560722 8195684 2161241..2161456 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2161456 8195684 METDI2268 Methylobacterium extorquens DM4 hypothetical protein YP_003067817.1 2161241 D 661410 CDS YP_003067818.1 254560723 8192301 complement(2161550..2162752) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2162752 8192301 METDI2269 Methylobacterium extorquens DM4 hypothetical protein YP_003067818.1 2161550 R 661410 CDS YP_003067819.1 254560724 8192302 2162960..2164012 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative glycoside hydrolase/deacetylase 2164012 8192302 METDI2270 Methylobacterium extorquens DM4 putative glycoside hydrolase/deacetylase YP_003067819.1 2162960 D 661410 CDS YP_003067820.1 254560725 8192303 complement(2164025..2164462) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2164462 8192303 METDI2271 Methylobacterium extorquens DM4 hypothetical protein YP_003067820.1 2164025 R 661410 CDS YP_003067821.1 254560726 8192304 complement(2164598..2164804) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2164804 8192304 METDI2272 Methylobacterium extorquens DM4 hypothetical protein YP_003067821.1 2164598 R 661410 CDS YP_003067822.1 254560727 8192305 2165178..2166326 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor; putative cytochrome c oxidase assembly protein 2166326 8192305 METDI2273 Methylobacterium extorquens DM4 putative cytochrome c oxidase assembly protein YP_003067822.1 2165178 D 661410 CDS YP_003067823.1 254560728 8192306 2166609..2167289 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 7495855; Product type pf : putative factor; putative hemolysin III, HlyIII family 2167289 8192306 METDI2274 Methylobacterium extorquens DM4 putative hemolysin III, HlyIII family YP_003067823.1 2166609 D 661410 CDS YP_003067824.1 254560729 8192307 complement(2167412..2167675) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2167675 8192307 METDI2275 Methylobacterium extorquens DM4 hypothetical protein YP_003067824.1 2167412 R 661410 CDS YP_003067825.1 254560730 8195037 2168113..2170005 1 NC_012988.1 required for the synthesis of the hydromethylpyrimidine moiety of thiamine; thiamine biosynthesis protein ThiC 2170005 thiC 8195037 thiC Methylobacterium extorquens DM4 thiamine biosynthesis protein ThiC YP_003067825.1 2168113 D 661410 CDS YP_003067826.1 254560731 8196185 2170222..2170569 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2170569 8196185 METDI2277 Methylobacterium extorquens DM4 hypothetical protein YP_003067826.1 2170222 D 661410 CDS YP_003067827.1 254560732 8192309 complement(2170746..2171120) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 1699845; Product type pr : putative regulator; putative flagellar protein FlaF 2171120 8192309 METDI2279 Methylobacterium extorquens DM4 putative flagellar protein FlaF YP_003067827.1 2170746 R 661410 CDS YP_003067828.1 254560733 8192310 2171298..2171537 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2171537 8192310 METDI2280 Methylobacterium extorquens DM4 hypothetical protein YP_003067828.1 2171298 D 661410 CDS YP_003067829.1 254560734 8192311 complement(2171662..2171802) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2171802 8192311 METDI2281 Methylobacterium extorquens DM4 hypothetical protein YP_003067829.1 2171662 R 661410 CDS YP_003067830.1 254560735 8192312 complement(2171986..2172312) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2172312 8192312 METDI2282 Methylobacterium extorquens DM4 hypothetical protein YP_003067830.1 2171986 R 661410 CDS YP_003067831.1 254560736 8192313 complement(2172548..2173117) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative phosphohydrolase/phosphoesterase 2173117 8192313 METDI2283 Methylobacterium extorquens DM4 putative phosphohydrolase/phosphoesterase YP_003067831.1 2172548 R 661410 CDS YP_003067832.1 254560737 8192314 complement(2173175..2174311) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative TonB family C-terminal domain protein 2174311 8192314 METDI2284 Methylobacterium extorquens DM4 putative TonB family C-terminal domain protein YP_003067832.1 2173175 R 661410 CDS YP_003067833.1 254560738 8192315 complement(2174316..2174777) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 1644779, 2670903, 88273230, 93302502; Product type m : membrane component; enterobactin uptake protein 2174777 exbD 8192315 exbD Methylobacterium extorquens DM4 enterobactin uptake protein YP_003067833.1 2174316 R 661410 CDS YP_003067834.1 254560739 8195339 complement(2174862..2175563) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type m : membrane component; membrane spanning protein in TonB-ExbB-ExbD complex 2175563 8195339 METDI2286 Methylobacterium extorquens DM4 membrane spanning protein in TonB-ExbB-ExbD complex YP_003067834.1 2174862 R 661410 CDS YP_003067835.1 254560740 8192316 complement(2175635..2176117) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2176117 8192316 METDI2287 Methylobacterium extorquens DM4 hypothetical protein YP_003067835.1 2175635 R 661410 CDS YP_003067836.1 254560741 8192317 2176685..2177116 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type f : factor; small heat shock protein 2177116 ibpA 8192317 ibpA Methylobacterium extorquens DM4 small heat shock protein YP_003067836.1 2176685 D 661410 CDS YP_003067837.1 254560742 8195585 2177290..2177571 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2177571 8195585 METDI2289 Methylobacterium extorquens DM4 hypothetical protein YP_003067837.1 2177290 D 661410 CDS YP_003067838.1 254560743 8192318 complement(2177603..2178388) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2178388 8192318 METDI2290 Methylobacterium extorquens DM4 hypothetical protein YP_003067838.1 2177603 R 661410 CDS YP_003067839.1 254560744 8192319 2178514..2179743 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11157937; Product type pe : putative enzyme; putative glycosyl transferase 2179743 8192319 METDI2291 Methylobacterium extorquens DM4 putative glycosyl transferase YP_003067839.1 2178514 D 661410 CDS YP_003067840.1 254560745 8192320 2179920..2180441 1 NC_012988.1 IF-3 has several functions that are required and promote translation initiation including; preventing association of 70S by binding to 30S; monitoring codon-anticodon interactions by promoting disassociation of fMet-tRNA(fMet) from initiation complexes formed on leaderless mRNAs or incorrectly bound noninitiatior tRNAs and complexes with noncanonical start sites; stimulates codon-anticodon interactions at P-site; involved in moving mRNA to the P-site; and in recycling subunits; translation initiation factor IF-3 2180441 infC 8192320 infC Methylobacterium extorquens DM4 translation initiation factor IF-3 YP_003067840.1 2179920 D 661410 CDS YP_003067841.1 254560746 8195599 complement(2180634..2182970) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2182970 8195599 METDI2293 Methylobacterium extorquens DM4 hypothetical protein YP_003067841.1 2180634 R 661410 CDS YP_003067842.1 254560747 8192321 complement(2183129..2184262) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15838019, 16934238; Product type pe : putative enzyme; putative glycosyl transferase 2184262 8192321 METDI2294 Methylobacterium extorquens DM4 putative glycosyl transferase YP_003067842.1 2183129 R 661410 CDS YP_003067843.1 254560748 8192322 2184717..2184920 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 10094780, 3298224, 3542048, 6325158, 93085722; Product type s : structure; 50S ribosomal protein L35 2184920 rpmI 8192322 rpmI Methylobacterium extorquens DM4 50S ribosomal protein L35 YP_003067843.1 2184717 D 661410 CDS YP_003067844.1 254560749 8196042 2184973..2185338 1 NC_012988.1 binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit; 50S ribosomal protein L20 2185338 rplT 8196042 rplT Methylobacterium extorquens DM4 50S ribosomal protein L20 YP_003067844.1 2184973 D 661410 CDS YP_003067845.1 254560750 8196029 2185523..2186602 1 NC_012988.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a heterotetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 1 subfamily; phenylalanyl-tRNA synthetase subunit alpha 2186602 pheS 8196029 pheS Methylobacterium extorquens DM4 phenylalanyl-tRNA synthetase subunit alpha YP_003067845.1 2185523 D 661410 CDS YP_003067846.1 254560751 8195858 2186667..2189090 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; phenylalanine tRNA synthetase, beta-subunit 2189090 pheT 8195858 pheT Methylobacterium extorquens DM4 phenylalanine tRNA synthetase, beta-subunit YP_003067846.1 2186667 D 661410 CDS YP_003067847.1 254560752 8195859 2189116..2189991 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2189991 8195859 METDI2299 Methylobacterium extorquens DM4 hypothetical protein YP_003067847.1 2189116 D 661410 CDS YP_003067848.1 254560753 8192323 complement(2189939..2190766) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 11463785, 88314906, 90148107, 8514782, 93368423; Product type e : enzyme; molybdopterin synthase sulfurylase 2190766 moeB 8192323 moeB Methylobacterium extorquens DM4 molybdopterin synthase sulfurylase YP_003067848.1 2189939 R 661410 CDS YP_003067849.1 254560754 8195715 2191032..2192198 1 NC_012988.1 dapE-encoded N-succinyl-L,L-diaminopimelic acid desuccinylase (DapE), catalyzes the hydrolysis of N-succinyl-L,Ldiaminopimelate L,L-SDAP to L,L-diaminopimelate and succinate. It is a metalloprotease containing dinuclear active sites. Its structure is similar to the carboxypeptidase G2 from Pseudomonas sp. strain RS-16 and the aminopeptidase from Aeromonas proteolytica.; succinyl-diaminopimelate desuccinylase 2192198 dapE 8195715 dapE Methylobacterium extorquens DM4 succinyl-diaminopimelate desuccinylase YP_003067849.1 2191032 D 661410 CDS YP_003067850.1 254560755 8195273 complement(2192359..2193111) 1 NC_012988.1 mediates pseudouridylation (positions 38, 39, 40) at the tRNA anticodon region which contributes to the structural stability; tRNA pseudouridine synthase A 2193111 truA 8195273 truA Methylobacterium extorquens DM4 tRNA pseudouridine synthase A YP_003067850.1 2192359 R 661410 CDS YP_003067851.1 254560756 8196280 complement(2193125..2194054) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; 10-formyltetrahydrofolate:L-methionyl-tRNA(fMet) N-formyltransferase 2194054 fmt 8196280 fmt Methylobacterium extorquens DM4 10-formyltetrahydrofolate:L-methionyl-tRNA(fMet) N-formyltransferase YP_003067851.1 2193125 R 661410 CDS YP_003067852.1 254560757 8195434 complement(2194065..2194580) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type e : enzyme; peptide deformylase 2194580 def 8195434 def Methylobacterium extorquens DM4 peptide deformylase YP_003067852.1 2194065 R 661410 CDS YP_003067853.1 254560758 8195284 complement(2194836..2196122) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2196122 8195284 METDI2305 Methylobacterium extorquens DM4 hypothetical protein YP_003067853.1 2194836 R 661410 CDS YP_003067854.1 254560759 8192324 complement(2196237..2196842) 1 NC_012988.1 involved in a recombinational process of DNA repair, independent of the recBC complex; recombination protein RecR 2196842 recR 8192324 recR Methylobacterium extorquens DM4 recombination protein RecR YP_003067854.1 2196237 R 661410 CDS YP_003067855.1 254560760 8195975 2197170..2198789 1 NC_012988.1 PEP carboxykinase; PEP carboxylase; PEPCK; catalyzes the phosphorylation and decarboxylation of oxaloacetate to form phosphoenolpyruvate using ATP; phosphoenolpyruvate carboxykinase 2198789 pck 8195975 pck Methylobacterium extorquens DM4 phosphoenolpyruvate carboxykinase YP_003067855.1 2197170 D 661410 CDS YP_003067856.1 254560761 8195834 complement(2198836..2200113) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative Fe-S containing enzyme (yfgB) 2200113 8195834 METDI2308 Methylobacterium extorquens DM4 putative Fe-S containing enzyme (yfgB) YP_003067856.1 2198836 R 661410 CDS YP_003067857.1 254560762 8192325 complement(2200230..2201969) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; bifunctional shikimate kinase (N-terminal) / dehydroquinate synthase (C-terminal) enzyme 2201969 8192325 METDI2309 Methylobacterium extorquens DM4 bifunctional shikimate kinase (N-terminal) / dehydroquinate synthase (C-terminal) enzyme YP_003067857.1 2200230 R 661410 CDS YP_003067858.1 254560763 8192326 2202218..2202952 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcriptional regulator (helix-turn-helix structure) 2202952 8192326 METDI2310 Methylobacterium extorquens DM4 putative transcriptional regulator (helix-turn-helix structure) YP_003067858.1 2202218 D 661410 CDS YP_003067859.1 254560764 8192327 2203303..2204265 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 15188393, 16926146, 8550482; Product type e : enzyme; malate dehydrogenase 2204265 mdh 8192327 mdh Methylobacterium extorquens DM4 malate dehydrogenase YP_003067859.1 2203303 D 661410 CDS YP_003067860.1 254560765 8195675 2204343..2205539 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 10625475, 10671455, 9917402; Product type e : enzyme; succinyl-CoA synthetase, beta subunit 2205539 sucC 8195675 sucC Methylobacterium extorquens DM4 succinyl-CoA synthetase, beta subunit YP_003067860.1 2204343 D 661410 CDS YP_003067861.1 254560766 8196167 2205548..2206435 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type e : enzyme; succinyl-CoA synthetase, alpha subunit 2206435 sucD 8196167 sucD Methylobacterium extorquens DM4 succinyl-CoA synthetase, alpha subunit YP_003067861.1 2205548 D 661410 CDS YP_003067862.1 254560767 8196169 2206660..2209650 1 NC_012988.1 SucA; E1 component of the oxoglutarate dehydrogenase complex which catalyzes the formation of succinyl-CoA from 2-oxoglutarate; SucA catalyzes the reaction of 2-oxoglutarate with dihydrolipoamide succinyltransferase-lipoate to form dihydrolipoamide succinyltransferase-succinyldihydrolipoate and carbon dioxide; 2-oxoglutarate dehydrogenase E1 component 2209650 sucA 8196169 sucA Methylobacterium extorquens DM4 2-oxoglutarate dehydrogenase E1 component YP_003067862.1 2206660 D 661410 CDS YP_003067863.1 254560768 8196164 2209734..2211074 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type e : enzyme; dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex 2211074 sucB 8196164 sucB Methylobacterium extorquens DM4 dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex YP_003067863.1 2209734 D 661410 CDS YP_003067864.1 254560769 8196165 2211363..2212766 1 NC_012988.1 Catalyzes the oxidation of dihydrolipoamide to lipoamide; dihydrolipoamide dehydrogenase 2212766 lpd 8196165 lpd Methylobacterium extorquens DM4 dihydrolipoamide dehydrogenase YP_003067864.1 2211363 D 661410 CDS YP_003067865.1 254560770 8195644 2212966..2214591 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; histidine kinase 2214591 8195644 METDI2317 Methylobacterium extorquens DM4 histidine kinase YP_003067865.1 2212966 D 661410 CDS YP_003067866.1 254560771 8192328 2214650..2215282 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2215282 8192328 METDI2318 Methylobacterium extorquens DM4 hypothetical protein YP_003067866.1 2214650 D 661410 CDS YP_003067867.1 254560772 8192329 complement(2215264..2215893) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; sarcosine oxidase, gamma subunit 2215893 soxG 8192329 soxG Methylobacterium extorquens DM4 sarcosine oxidase, gamma subunit YP_003067867.1 2215264 R 661410 CDS YP_003067868.1 254560773 8196132 complement(2215886..2218915) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 7543100; Product type pe : putative enzyme; sarcosine oxidase, alpha subunit 2218915 soxA 8196132 soxA Methylobacterium extorquens DM4 sarcosine oxidase, alpha subunit YP_003067868.1 2215886 R 661410 CDS YP_003067869.1 254560774 8196124 complement(2218912..2219199) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 7543100; Product type e : enzyme; sarcosine oxidase, delta subunit 2219199 soxD 8196124 soxD Methylobacterium extorquens DM4 sarcosine oxidase, delta subunit YP_003067869.1 2218912 R 661410 CDS YP_003067870.1 254560775 8196130 complement(2219317..2220567) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 7692961, 8611516, 9485355; Product type e : enzyme; sarcosine oxidase beta subunit 2220567 soxB 8196130 soxB Methylobacterium extorquens DM4 sarcosine oxidase beta subunit YP_003067870.1 2219317 R 661410 CDS YP_003067871.1 254560776 8196127 2220768..2221766 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 9286980; Product type pr : putative regulator; transcriptional regulator, AraC family 2221766 8196127 METDI2323 Methylobacterium extorquens DM4 transcriptional regulator, AraC family YP_003067871.1 2220768 D 661410 CDS YP_003067872.1 254560777 8192330 2221941..2222876 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative amidotransferase; glutamine amidotransferase class-II domain 2222876 8192330 METDI2324 Methylobacterium extorquens DM4 putative amidotransferase; glutamine amidotransferase class-II domain YP_003067872.1 2221941 D 661410 CDS YP_003067873.1 254560778 8192331 2222876..2223565 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative GXGXG-motif protein, glutamate synthase and formylmethanofuran dehydrogenase-like domain 2223565 8192331 METDI2325 Methylobacterium extorquens DM4 putative GXGXG-motif protein, glutamate synthase and formylmethanofuran dehydrogenase-like domain YP_003067873.1 2222876 D 661410 CDS YP_003067874.1 254560779 8192332 2223565..2224908 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; FMN-dependent dehydrogenase with conserved glutamate synthase region 2224908 8192332 METDI2326 Methylobacterium extorquens DM4 FMN-dependent dehydrogenase with conserved glutamate synthase region YP_003067874.1 2223565 D 661410 CDS YP_003067875.1 254560780 8192333 2224998..2226296 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 1356885, 18175924; Product type pe : putative enzyme; putative gamma-glutamylmethylamide synthetase; glutamine synthetase type III family 2226296 8192333 METDI2327 Methylobacterium extorquens DM4 putative gamma-glutamylmethylamide synthetase; glutamine synthetase type III family YP_003067875.1 2224998 D 661410 CDS YP_003067876.1 254560781 8192334 2226486..2226995 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2226995 8192334 METDI2328 Methylobacterium extorquens DM4 hypothetical protein YP_003067876.1 2226486 D 661410 CDS YP_003067877.1 254560782 8192336 2228008..2238864 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative heme peroxidase with hemolysin-type calcium-binding domain 2238864 8192336 METDI2330 Methylobacterium extorquens DM4 putative heme peroxidase with hemolysin-type calcium-binding domain YP_003067877.1 2228008 D 661410 CDS YP_003067878.1 254560783 8192337 2238925..2240691 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 10388672, 11467725, 2184029; Product type t : transporter; type I secretion system ATPase 2240691 8192337 METDI2331 Methylobacterium extorquens DM4 type I secretion system ATPase YP_003067878.1 2238925 D 661410 CDS YP_003067879.1 254560784 8192338 2240688..2242943 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2242943 8192338 METDI2332 Methylobacterium extorquens DM4 hypothetical protein YP_003067879.1 2240688 D 661410 CDS YP_003067880.1 254560785 8192339 2242965..2244311 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type t : transporter; type I secretion membrane fusion protein, HlyD family 2244311 8192339 METDI2333 Methylobacterium extorquens DM4 type I secretion membrane fusion protein, HlyD family YP_003067880.1 2242965 D 661410 CDS YP_003067881.1 254560786 8192340 2244555..2245022 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2245022 8192340 METDI2334 Methylobacterium extorquens DM4 hypothetical protein YP_003067881.1 2244555 D 661410 CDS YP_003067882.1 254560787 8192341 2245072..2246193 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2246193 8192341 METDI2335 Methylobacterium extorquens DM4 hypothetical protein YP_003067882.1 2245072 D 661410 CDS YP_003067883.1 254560788 8192342 2246186..2246854 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type r : regulator; two-component transcriptional regulator, LuxR family 2246854 8192342 METDI2336 Methylobacterium extorquens DM4 two-component transcriptional regulator, LuxR family YP_003067883.1 2246186 D 661410 CDS YP_003067884.1 254560789 8192343 complement(2247218..2248093) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; Esterase/lipase-like protein 2248093 8192343 METDI2337 Methylobacterium extorquens DM4 Esterase/lipase-like protein YP_003067884.1 2247218 R 661410 CDS YP_003067885.1 254560790 8192344 complement(2248193..2249002) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative ubiE/COQ5 methyltransferase family enzyme 2249002 8192344 METDI2338 Methylobacterium extorquens DM4 putative ubiE/COQ5 methyltransferase family enzyme YP_003067885.1 2248193 R 661410 CDS YP_003067886.1 254560791 8192345 2249658..2255471 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2255471 8192345 METDI2339 Methylobacterium extorquens DM4 hypothetical protein YP_003067886.1 2249658 D 661410 CDS YP_003067887.1 254560792 8192346 2255468..2257555 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative sensor hybrid histidine kinase with PAS and two responser regulator receiver domains 2257555 8192346 METDI2340 Methylobacterium extorquens DM4 putative sensor hybrid histidine kinase with PAS and two responser regulator receiver domains YP_003067887.1 2255468 D 661410 CDS YP_003067888.1 254560793 8192347 complement(2257826..2258695) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2258695 8192347 METDI2341 Methylobacterium extorquens DM4 hypothetical protein YP_003067888.1 2257826 R 661410 CDS YP_003067889.1 254560794 8192348 2258799..2259692 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type r : regulator; Transcriptional regulator, LysR family 2259692 8192348 METDI2342 Methylobacterium extorquens DM4 Transcriptional regulator, LysR family YP_003067889.1 2258799 D 661410 CDS YP_003067890.1 254560795 8192351 complement(2262156..2262554) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2262554 8192351 METDI2345 Methylobacterium extorquens DM4 hypothetical protein YP_003067890.1 2262156 R 661410 CDS YP_003067891.1 254560796 8192352 2262680..2263570 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type r : regulator; transcriptional regulator, LysR family 2263570 8192352 METDI2346 Methylobacterium extorquens DM4 transcriptional regulator, LysR family YP_003067891.1 2262680 D 661410 CDS YP_003067892.1 254560797 8192353 complement(2263626..2263808) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2263808 8192353 METDI2347 Methylobacterium extorquens DM4 hypothetical protein YP_003067892.1 2263626 R 661410 CDS YP_003067893.1 254560798 8192354 complement(2263918..2264580) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11714269, 3062312, 9782055; Product type pe : putative enzyme; putative enzyme with cysteine hydrolase domain 2264580 ycaC 8192354 ycaC Methylobacterium extorquens DM4 putative enzyme with cysteine hydrolase domain YP_003067893.1 2263918 R 661410 CDS YP_003067894.1 254560799 8196353 complement(2264674..2265630) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; Zinc-containing alcohol dehydrogenase superfamily 2265630 8196353 METDI2349 Methylobacterium extorquens DM4 Zinc-containing alcohol dehydrogenase superfamily YP_003067894.1 2264674 R 661410 CDS YP_003067895.1 254560800 8192355 2265726..2266664 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type r : regulator; transcriptional regulator, LysR family 2266664 8192355 METDI2350 Methylobacterium extorquens DM4 transcriptional regulator, LysR family YP_003067895.1 2265726 D 661410 CDS YP_003067896.1 254560801 8192356 complement(2267248..2267622) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2267622 8192356 METDI2351 Methylobacterium extorquens DM4 hypothetical protein YP_003067896.1 2267248 R 661410 CDS YP_003067897.1 254560802 8192357 2268432..2269124 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2269124 8192357 METDI2352 Methylobacterium extorquens DM4 hypothetical protein YP_003067897.1 2268432 D 661410 CDS YP_003067898.1 254560803 8192358 2269187..2270065 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcriptional regulator, LysR family 2270065 8192358 METDI2353 Methylobacterium extorquens DM4 putative transcriptional regulator, LysR family YP_003067898.1 2269187 D 661410 CDS YP_003067899.1 254560804 8192359 2270149..2270445 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2270445 8192359 METDI2354 Methylobacterium extorquens DM4 hypothetical protein YP_003067899.1 2270149 D 661410 CDS YP_003067900.1 254560805 8192360 complement(2270518..2270943) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2270943 8192360 METDI2355 Methylobacterium extorquens DM4 hypothetical protein YP_003067900.1 2270518 R 661410 CDS YP_003067901.1 254560806 8192361 complement(2270907..2271257) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2271257 8192361 METDI2356 Methylobacterium extorquens DM4 hypothetical protein YP_003067901.1 2270907 R 661410 CDS YP_003067902.1 254560807 8192362 complement(2271397..2272413) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; NADPH quinone oxidoreductase, Zinc-containing alcohol dehydrogenase superfamily 2272413 8192362 METDI2357 Methylobacterium extorquens DM4 NADPH quinone oxidoreductase, Zinc-containing alcohol dehydrogenase superfamily YP_003067902.1 2271397 R 661410 CDS YP_003067903.1 254560808 8192363 complement(2272441..2273301) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2273301 8192363 METDI2358 Methylobacterium extorquens DM4 hypothetical protein YP_003067903.1 2272441 R 661410 CDS YP_003067904.1 254560809 8192364 2274014..2275738 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative sensor histidine kinase, putative diguanylate cyclase (GGDEF) domain 2275738 8192364 METDI2359 Methylobacterium extorquens DM4 putative sensor histidine kinase, putative diguanylate cyclase (GGDEF) domain YP_003067904.1 2274014 D 661410 CDS YP_003067905.1 254560810 8192366 complement(2276398..2276727) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2276727 8192366 METDI2361 Methylobacterium extorquens DM4 hypothetical protein YP_003067905.1 2276398 R 661410 CDS YP_003067906.1 254560811 8192367 complement(2276821..2281986) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative amidase-related protein 2281986 8192367 METDI2362 Methylobacterium extorquens DM4 putative amidase-related protein YP_003067906.1 2276821 R 661410 CDS YP_003067907.1 254560812 8192369 2282629..2284029 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type t : transporter; transporter 2284029 ygfU 8192369 ygfU Methylobacterium extorquens DM4 transporter YP_003067907.1 2282629 D 661410 CDS YP_003067908.1 254560813 8196364 complement(2284156..2284563) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2284563 8196364 METDI2365 Methylobacterium extorquens DM4 hypothetical protein YP_003067908.1 2284156 R 661410 CDS YP_003067909.1 254560814 8192370 complement(2284560..2285975) 1 NC_012988.1 catalyzes the hydrolysis of a monocarboxylic acid amid to form a monocarboxylate and ammonia; amidase 2285975 8192370 METDI2366 Methylobacterium extorquens DM4 amidase YP_003067909.1 2284560 R 661410 CDS YP_003067910.1 254560815 8192371 complement(2285972..2286175) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2286175 8192371 METDI2367 Methylobacterium extorquens DM4 hypothetical protein YP_003067910.1 2285972 R 661410 CDS YP_003067911.1 254560816 8192372 complement(2286278..2286958) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16540542; Product type pe : putative enzyme; putative isochorismatase family protein RutB (Pyrimidine utilization protein B) 2286958 8192372 METDI2368 Methylobacterium extorquens DM4 putative isochorismatase family protein RutB (Pyrimidine utilization protein B) YP_003067911.1 2286278 R 661410 CDS YP_003067912.1 254560817 8192373 complement(2287249..2287443) 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 2287443 8192373 METDI2369 Methylobacterium extorquens DM4 hypothetical protein YP_003067912.1 2287249 R 661410 CDS YP_003067913.1 254560818 8192374 2287466..2288461 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2288461 8192374 METDI2370 Methylobacterium extorquens DM4 hypothetical protein YP_003067913.1 2287466 D 661410 CDS YP_003067914.1 254560819 8192375 2288487..2289851 1 NC_012988.1 catalyzes the transformation of hydroxyatrazine to N-isopropylammelide and ethylamine in the atrazine degradation pathway.; hydroxydechloroatrazine ethylaminohydrolase 2289851 atzB 8192375 atzB Methylobacterium extorquens DM4 hydroxydechloroatrazine ethylaminohydrolase YP_003067914.1 2288487 D 661410 CDS YP_003067915.1 254560820 8195122 2289851..2291455 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative methyl-galactoside transporter, ATP-binding component of sugar ABC transporter (mglA-like) 2291455 8195122 METDI2372 Methylobacterium extorquens DM4 putative methyl-galactoside transporter, ATP-binding component of sugar ABC transporter (mglA-like) YP_003067915.1 2289851 D 661410 CDS YP_003067916.1 254560821 8192376 2291514..2292608 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative L-arabinose transporter, membrane component of sugar ABC transporter (araH-like) 2292608 8192376 METDI2373 Methylobacterium extorquens DM4 putative L-arabinose transporter, membrane component of sugar ABC transporter (araH-like) YP_003067916.1 2291514 D 661410 CDS YP_003067917.1 254560822 8192377 2292605..2293531 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative ABC transporter protein, permease component 2293531 8192377 METDI2374 Methylobacterium extorquens DM4 putative ABC transporter protein, permease component YP_003067917.1 2292605 D 661410 CDS YP_003067918.1 254560823 8192378 2293697..2294836 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative ABC transporter (substrate-binding protein precursor) (tat pathway signal) 2294836 8192378 METDI2375 Methylobacterium extorquens DM4 putative ABC transporter (substrate-binding protein precursor) (tat pathway signal) YP_003067918.1 2293697 D 661410 CDS YP_003067919.1 254560824 8192379 2295010..2296167 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative permease component of sugar ABC transporter 2296167 8192379 METDI2376 Methylobacterium extorquens DM4 putative permease component of sugar ABC transporter YP_003067919.1 2295010 D 661410 CDS YP_003067920.1 254560825 8192380 2296190..2297110 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative membrane component of sugar ABC transporter 2297110 8192380 METDI2377 Methylobacterium extorquens DM4 putative membrane component of sugar ABC transporter YP_003067920.1 2296190 D 661410 CDS YP_003067921.1 254560826 8192381 2297120..2298148 1 NC_012988.1 formamide amidohydrolase; catalyzes the hydrolysis of formamide to formate; formamidase 2298148 amiF 8192381 amiF Methylobacterium extorquens DM4 formamidase YP_003067921.1 2297120 D 661410 CDS YP_003067922.1 254560827 8195066 2298145..2298864 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative Isochorismatase hydrolase family 2298864 8195066 METDI2379 Methylobacterium extorquens DM4 putative Isochorismatase hydrolase family YP_003067922.1 2298145 D 661410 CDS YP_003067923.1 254560828 8192382 2298872..2300422 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative ATP-binding protein of sugar ABC transporter 2300422 8192382 METDI2380 Methylobacterium extorquens DM4 putative ATP-binding protein of sugar ABC transporter YP_003067923.1 2298872 D 661410 CDS YP_003067924.1 254560829 8192383 complement(2300763..2301575) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2301575 8192383 METDI2381 Methylobacterium extorquens DM4 hypothetical protein YP_003067924.1 2300763 R 661410 CDS YP_003067925.1 254560830 8192384 2301912..2302985 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type s : structure; Basic membrane lipoprotein 2302985 8192384 METDI2382 Methylobacterium extorquens DM4 Basic membrane lipoprotein YP_003067925.1 2301912 D 661410 CDS YP_003067926.1 254560831 8192385 complement(2303061..2303342) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2303342 8192385 METDI2383 Methylobacterium extorquens DM4 hypothetical protein YP_003067926.1 2303061 R 661410 CDS YP_003067927.1 254560832 8192386 complement(2303414..2303620) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2303620 8192386 METDI2384 Methylobacterium extorquens DM4 hypothetical protein YP_003067927.1 2303414 R 661410 CDS YP_003067928.1 254560833 8192387 complement(2303709..2305355) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; Peptidase S15 2305355 8192387 METDI2385 Methylobacterium extorquens DM4 Peptidase S15 YP_003067928.1 2303709 R 661410 CDS YP_003067929.1 254560834 8192388 complement(2305345..2306166) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative creatininase (creatine amidohydrolase) 2306166 8192388 METDI2386 Methylobacterium extorquens DM4 putative creatininase (creatine amidohydrolase) YP_003067929.1 2305345 R 661410 CDS YP_003067930.1 254560835 8192389 complement(2306163..2307722) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative Long-chain-fatty-acid--CoA ligase (Long-chain acyl-CoA synthetase) (Acyl-CoA synthetase) (putative fadD) 2307722 8192389 METDI2387 Methylobacterium extorquens DM4 putative Long-chain-fatty-acid--CoA ligase (Long-chain acyl-CoA synthetase) (Acyl-CoA synthetase) (putative fadD) YP_003067930.1 2306163 R 661410 CDS YP_003067931.1 254560836 8192390 complement(2307762..2308349) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative NAD(P)H dehydrogenase (quione) 2308349 8192390 METDI2388 Methylobacterium extorquens DM4 putative NAD(P)H dehydrogenase (quione) YP_003067931.1 2307762 R 661410 CDS YP_003067932.1 254560837 8192391 complement(2308346..2309734) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2309734 8192391 METDI2389 Methylobacterium extorquens DM4 hypothetical protein YP_003067932.1 2308346 R 661410 CDS YP_003067933.1 254560838 8192392 complement(2309736..2310707) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative 2OG-Fe(II) oxygenase superfamily 2310707 8192392 METDI2390 Methylobacterium extorquens DM4 putative 2OG-Fe(II) oxygenase superfamily YP_003067933.1 2309736 R 661410 CDS YP_003067934.1 254560839 8192393 complement(2310720..2311688) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative ABC transporter protein, periplasmic substrate-binding component precursor 2311688 8192393 METDI2391 Methylobacterium extorquens DM4 putative ABC transporter protein, periplasmic substrate-binding component precursor YP_003067934.1 2310720 R 661410 CDS YP_003067935.1 254560840 8192394 complement(2311688..2312761) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type cp : cell process; rieske 2Fe-2S family protein 2312761 8192394 METDI2392 Methylobacterium extorquens DM4 rieske 2Fe-2S family protein YP_003067935.1 2311688 R 661410 CDS YP_003067936.1 254560841 8192395 complement(2312828..2313622) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative permease component of ABC transporter 2313622 8192395 METDI2393 Methylobacterium extorquens DM4 putative permease component of ABC transporter YP_003067936.1 2312828 R 661410 CDS YP_003067937.1 254560842 8192396 complement(2313619..2314557) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative ATP-binding component of ABC transporter 2314557 8192396 METDI2394 Methylobacterium extorquens DM4 putative ATP-binding component of ABC transporter YP_003067937.1 2313619 R 661410 CDS YP_003067938.1 254560843 8192397 complement(2314566..2315552) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative ABC transporter protein, periplasmic substrate-binding component precursor 2315552 8192397 METDI2395 Methylobacterium extorquens DM4 putative ABC transporter protein, periplasmic substrate-binding component precursor YP_003067938.1 2314566 R 661410 CDS YP_003067939.1 254560844 8192398 2315879..2316784 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcriptional regulator, LysR family 2316784 8192398 METDI2396 Methylobacterium extorquens DM4 putative transcriptional regulator, LysR family YP_003067939.1 2315879 D 661410 CDS YP_003067940.1 254560845 8192399 2316864..2318243 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; cytosine deaminase-like protein 2318243 8192399 METDI2397 Methylobacterium extorquens DM4 cytosine deaminase-like protein YP_003067940.1 2316864 D 661410 CDS YP_003067941.1 254560846 8192400 2318538..2318786 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2318786 8192400 METDI2398 Methylobacterium extorquens DM4 hypothetical protein YP_003067941.1 2318538 D 661410 CDS YP_003067942.1 254560847 8192401 2319049..2319279 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2319279 8192401 METDI2399 Methylobacterium extorquens DM4 hypothetical protein YP_003067942.1 2319049 D 661410 CDS YP_003067943.1 254560848 8192402 2319461..2320384 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type r : regulator; transcriptional regulator, LysR family 2320384 8192402 METDI2400 Methylobacterium extorquens DM4 transcriptional regulator, LysR family YP_003067943.1 2319461 D 661410 CDS YP_003067944.1 254560849 8192403 complement(2320412..2321770) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; guanine deaminase 2321770 guaD 8192403 guaD Methylobacterium extorquens DM4 guanine deaminase YP_003067944.1 2320412 R 661410 CDS YP_003067945.1 254560850 8195541 complement(2321767..2324547) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative oxidoreductase, molybdopterin-binding subunit 2324547 8195541 METDI2402 Methylobacterium extorquens DM4 putative oxidoreductase, molybdopterin-binding subunit YP_003067945.1 2321767 R 661410 CDS YP_003067946.1 254560851 8192404 complement(2324544..2325359) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative oxidoreductase, FAD-binding subunit 2325359 8192404 METDI2403 Methylobacterium extorquens DM4 putative oxidoreductase, FAD-binding subunit YP_003067946.1 2324544 R 661410 CDS YP_003067947.1 254560852 8192405 complement(2325500..2326489) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2326489 8192405 METDI2404 Methylobacterium extorquens DM4 hypothetical protein YP_003067947.1 2325500 R 661410 CDS YP_003067948.1 254560853 8192406 complement(2326594..2327559) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type t : transporter; ATP-binding protein of ABC family transporter 2327559 8192406 METDI2405 Methylobacterium extorquens DM4 ATP-binding protein of ABC family transporter YP_003067948.1 2326594 R 661410 CDS YP_003067949.1 254560854 8192407 complement(2327556..2328464) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type t : transporter; ABC family transporter permease protein 2328464 8192407 METDI2406 Methylobacterium extorquens DM4 ABC family transporter permease protein YP_003067949.1 2327556 R 661410 CDS YP_003067950.1 254560855 8192408 complement(2328454..2329308) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type t : transporter; ABC family transporter substrate-binding protein 2329308 8192408 METDI2407 Methylobacterium extorquens DM4 ABC family transporter substrate-binding protein YP_003067950.1 2328454 R 661410 CDS YP_003067951.1 254560856 8192409 complement(2329509..2330126) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; flavin reductase domain protein, FMN-binding 2330126 8192409 METDI2408 Methylobacterium extorquens DM4 flavin reductase domain protein, FMN-binding YP_003067951.1 2329509 R 661410 CDS YP_003067952.1 254560857 8192410 complement(2330158..2330940) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative enzyme of alternative pyrimidine degradation pathway, putative alpha/beta hydrolase 2330940 rutD 8192410 rutD Methylobacterium extorquens DM4 putative enzyme of alternative pyrimidine degradation pathway, putative alpha/beta hydrolase YP_003067952.1 2330158 R 661410 CDS YP_003067953.1 254560858 8196094 complement(2330945..2331337) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 16540542; Product type e : enzyme; enzyme of alternative pyrimidine degradation pathway 2331337 rutC 8196094 rutC Methylobacterium extorquens DM4 enzyme of alternative pyrimidine degradation pathway YP_003067953.1 2330945 R 661410 CDS YP_003067954.1 254560859 8196093 complement(2331350..2332096) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 16540542; Product type e : enzyme; enzyme of alternative pyrimidine degradation pathway 2332096 rutB 8196093 rutB Methylobacterium extorquens DM4 enzyme of alternative pyrimidine degradation pathway YP_003067954.1 2331350 R 661410 CDS YP_003067955.1 254560860 8196092 complement(2332096..2333190) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative luciferase family protein, putative flavin-dependent oxidoreductase 2333190 8196092 METDI2412 Methylobacterium extorquens DM4 putative luciferase family protein, putative flavin-dependent oxidoreductase YP_003067955.1 2332096 R 661410 CDS YP_003067956.1 254560861 8192411 complement(2333449..2334231) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcriptional regulator, TetR/AcrR family 2334231 8192411 METDI2413 Methylobacterium extorquens DM4 putative transcriptional regulator, TetR/AcrR family YP_003067956.1 2333449 R 661410 CDS YP_003067957.1 254560862 8192412 complement(2334218..2334715) 1 NC_012988.1 catalyzes the formation of glyoxylate from (S)-ureidoglycolate; ureidoglycolate hydrolase 2334715 allA 8192412 allA Methylobacterium extorquens DM4 ureidoglycolate hydrolase YP_003067957.1 2334218 R 661410 CDS YP_003067958.1 254560863 8195070 complement(2334712..2335551) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2335551 8195070 METDI2415 Methylobacterium extorquens DM4 hypothetical protein YP_003067958.1 2334712 R 661410 CDS YP_003067959.1 254560864 8192413 complement(2335591..2336826) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2336826 8192413 METDI2416 Methylobacterium extorquens DM4 hypothetical protein YP_003067959.1 2335591 R 661410 CDS YP_003067960.1 254560865 8192414 2336961..2337893 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type r : regulator; Transcriptional regulator, LysR family 2337893 8192414 METDI2417 Methylobacterium extorquens DM4 Transcriptional regulator, LysR family YP_003067960.1 2336961 D 661410 CDS YP_003067961.1 254560866 8192415 complement(2337924..2339336) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2339336 8192415 METDI2418 Methylobacterium extorquens DM4 hypothetical protein YP_003067961.1 2337924 R 661410 CDS YP_003067962.1 254560867 8192416 2339573..2339965 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2339965 8192416 METDI2419 Methylobacterium extorquens DM4 hypothetical protein YP_003067962.1 2339573 D 661410 CDS YP_003067963.1 254560868 8192417 2340024..2340359 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2340359 8192417 METDI2420 Methylobacterium extorquens DM4 hypothetical protein YP_003067963.1 2340024 D 661410 CDS YP_003067964.1 254560869 8192418 2340757..2341749 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2341749 8192418 METDI2422 Methylobacterium extorquens DM4 hypothetical protein YP_003067964.1 2340757 D 661410 CDS YP_003067965.1 254560870 8192419 2341998..2342981 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2342981 8192419 METDI2423 Methylobacterium extorquens DM4 hypothetical protein YP_003067965.1 2341998 D 661410 CDS YP_003067966.1 254560871 8192420 2343128..2344381 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16926146; Product type pe : putative enzyme; putative diguanylate cyclase with GGDEF motif; putative membrane protein 2344381 8192420 METDI2424 Methylobacterium extorquens DM4 putative diguanylate cyclase with GGDEF motif; putative membrane protein YP_003067966.1 2343128 D 661410 CDS YP_003067967.1 254560872 8192421 2344608..2345288 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; putative outer membrane protein, OmpW family 2345288 8192421 METDI2425 Methylobacterium extorquens DM4 putative outer membrane protein, OmpW family YP_003067967.1 2344608 D 661410 CDS YP_003067968.1 254560873 8192422 complement(2345568..2345930) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2345930 8192422 METDI2426 Methylobacterium extorquens DM4 hypothetical protein YP_003067968.1 2345568 R 661410 CDS YP_003067969.1 254560874 8192423 2346072..2346263 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 2346263 8192423 METDI2428 Methylobacterium extorquens DM4 hypothetical protein YP_003067969.1 2346072 D 661410 CDS YP_003067970.1 254560875 8192424 2346677..2346973 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2346973 8192424 METDI2429 Methylobacterium extorquens DM4 hypothetical protein YP_003067970.1 2346677 D 661410 CDS YP_003067971.1 254560876 8192425 complement(2347283..2347540) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2347540 8192425 METDI2430 Methylobacterium extorquens DM4 hypothetical protein YP_003067971.1 2347283 R 661410 CDS YP_003067972.1 254560877 8192426 2347651..2349459 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 2570061, 88106604; Product type e : enzyme; gamma-glutamyltranspeptidase 2349459 ggt 8192426 ggt Methylobacterium extorquens DM4 gamma-glutamyltranspeptidase YP_003067972.1 2347651 D 661410 CDS YP_003067973.1 254560878 8195482 complement(2349456..2350382) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative aminoglycoside phosphotransferase 2350382 8195482 METDI2432 Methylobacterium extorquens DM4 putative aminoglycoside phosphotransferase YP_003067973.1 2349456 R 661410 CDS YP_003067974.1 254560879 8192427 2350812..2351603 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16151217; Product type pe : putative enzyme; putative 1-acylglycerol-3-phosphate O-acyltransferase (plsC) 2351603 8192427 METDI2433 Methylobacterium extorquens DM4 putative 1-acylglycerol-3-phosphate O-acyltransferase (plsC) YP_003067974.1 2350812 D 661410 CDS YP_003067975.1 254560880 8192428 2351693..2351977 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2351977 8192428 METDI2434 Methylobacterium extorquens DM4 hypothetical protein YP_003067975.1 2351693 D 661410 CDS YP_003067976.1 254560881 8192429 2351931..2352260 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2352260 8192429 METDI2435 Methylobacterium extorquens DM4 hypothetical protein YP_003067976.1 2351931 D 661410 CDS YP_003067977.1 254560882 8192430 complement(2352318..2353007) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 11479715, 9721288; Product type e : enzyme; MetW (putative cysthationine synthase) 2353007 metW 8192430 metW Methylobacterium extorquens DM4 MetW (putative cysthationine synthase) YP_003067977.1 2352318 R 661410 CDS YP_003067978.1 254560883 8195686 complement(2353014..2354231) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 11479715, 12951250, 9209059; Product type e : enzyme; homoserine O-acetyltransferase 2354231 metX 8195686 metX Methylobacterium extorquens DM4 homoserine O-acetyltransferase YP_003067978.1 2353014 R 661410 CDS YP_003067979.1 254560884 8195687 2354635..2355138 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; methionine sulfoxide reductase (Peptide-methionine (R)-S-oxide reductase) 2355138 msrB 8195687 msrB Methylobacterium extorquens DM4 methionine sulfoxide reductase (Peptide-methionine (R)-S-oxide reductase) YP_003067979.1 2354635 D 661410 CDS YP_003067980.1 254560885 8195730 2355166..2355888 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; Peptide methionine sulfoxide reductase msrA (Protein-methionine-S-oxide reductase) (Peptide Met(O) reductase) 2355888 msrA 8195730 msrA Methylobacterium extorquens DM4 Peptide methionine sulfoxide reductase msrA (Protein-methionine-S-oxide reductase) (Peptide Met(O) reductase) YP_003067980.1 2355166 D 661410 CDS YP_003067981.1 254560886 8195727 complement(2355934..2356431) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type c : carrier; bacterioferritin, an iron storage homoprotein 2356431 bfr 8195727 bfr Methylobacterium extorquens DM4 bacterioferritin, an iron storage homoprotein YP_003067981.1 2355934 R 661410 CDS YP_003067982.1 254560887 8195140 complement(2356472..2356723) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2356723 8195140 METDI2441 Methylobacterium extorquens DM4 hypothetical protein YP_003067982.1 2356472 R 661410 CDS YP_003067983.1 254560888 8192431 complement(2357104..2357967) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2357967 8192431 METDI2442 Methylobacterium extorquens DM4 hypothetical protein YP_003067983.1 2357104 R 661410 CDS YP_003067984.1 254560889 8192432 complement(2358081..2359181) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type f : factor; Exopolysaccharide biosynthesis protein 2359181 8192432 METDI2443 Methylobacterium extorquens DM4 Exopolysaccharide biosynthesis protein YP_003067984.1 2358081 R 661410 CDS YP_003067985.1 254560890 8192433 2359352..2360062 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2360062 8192433 METDI2444 Methylobacterium extorquens DM4 hypothetical protein YP_003067985.1 2359352 D 661410 CDS YP_003067986.1 254560891 8192434 complement(2360323..2361459) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2361459 8192434 METDI2445 Methylobacterium extorquens DM4 hypothetical protein YP_003067986.1 2360323 R 661410 CDS YP_003067987.1 254560892 8192435 2361626..2362147 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2362147 8192435 METDI2446 Methylobacterium extorquens DM4 hypothetical protein YP_003067987.1 2361626 D 661410 CDS YP_003067988.1 254560893 8192436 complement(2362208..2362390) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2362390 8192436 METDI2447 Methylobacterium extorquens DM4 hypothetical protein YP_003067988.1 2362208 R 661410 CDS YP_003067989.1 254560894 8192437 complement(2362632..2362799) 1 NC_012988.1 in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif; 50S ribosomal protein L33 2362799 rpmG 8192437 rpmG Methylobacterium extorquens DM4 50S ribosomal protein L33 YP_003067989.1 2362632 R 661410 CDS YP_003067990.1 254560895 8196041 complement(2364454..2365278) 1 NC_012988.1 catalyzes the formation of tetrahydrofolate and 2-dehydropantoate from 5,10-methylenetetrahydrofolate and 3-methyl-2-oxobutanoate; 3-methyl-2-oxobutanoate hydroxymethyltransferase 2365278 panB 8196041 panB Methylobacterium extorquens DM4 3-methyl-2-oxobutanoate hydroxymethyltransferase YP_003067990.1 2364454 R 661410 CDS YP_003067991.1 254560896 8195823 complement(2365705..2366100) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; thioredoxin-related 2366100 8195823 METDI2452 Methylobacterium extorquens DM4 thioredoxin-related YP_003067991.1 2365705 R 661410 CDS YP_003067992.1 254560897 8192438 complement(2366131..2366718) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2366718 8192438 METDI2453 Methylobacterium extorquens DM4 hypothetical protein YP_003067992.1 2366131 R 661410 CDS YP_003067993.1 254560898 8192439 complement(2366736..2367551) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2367551 8192439 METDI2454 Methylobacterium extorquens DM4 hypothetical protein YP_003067993.1 2366736 R 661410 CDS YP_003067994.1 254560899 8192440 complement(2367593..2368525) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative metallo-hydrolase/oxidoreductase 2368525 8192440 METDI2455 Methylobacterium extorquens DM4 putative metallo-hydrolase/oxidoreductase YP_003067994.1 2367593 R 661410 CDS YP_003067995.1 254560900 8192441 2368708..2369286 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type r : regulator; Transcriptional regulator, TetR family 2369286 8192441 METDI2456 Methylobacterium extorquens DM4 Transcriptional regulator, TetR family YP_003067995.1 2368708 D 661410 CDS YP_003067996.1 254560901 8192442 2369313..2369609 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative nucleotidyltransferase 2369609 8192442 METDI2457 Methylobacterium extorquens DM4 putative nucleotidyltransferase YP_003067996.1 2369313 D 661410 CDS YP_003067997.1 254560902 8192443 2369609..2369983 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2369983 8192443 METDI2458 Methylobacterium extorquens DM4 hypothetical protein YP_003067997.1 2369609 D 661410 CDS YP_003067998.1 254560903 8192444 2370026..2371012 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 14556637; Product type pe : putative enzyme; putative GTPase, putative CobW-like cobalamin biosynthesis protein 2371012 8192444 METDI2459 Methylobacterium extorquens DM4 putative GTPase, putative CobW-like cobalamin biosynthesis protein YP_003067998.1 2370026 D 661410 CDS YP_003067999.1 254560904 8192445 complement(2371240..2371332) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2371332 8192445 METDI2460 Methylobacterium extorquens DM4 hypothetical protein YP_003067999.1 2371240 R 661410 CDS YP_003068000.1 254560905 8192446 complement(2371466..2371717) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2371717 8192446 METDI2461 Methylobacterium extorquens DM4 hypothetical protein YP_003068000.1 2371466 R 661410 CDS YP_003068001.1 254560906 8192447 2372304..2373731 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2373731 8192447 METDI2462 Methylobacterium extorquens DM4 hypothetical protein YP_003068001.1 2372304 D 661410 CDS YP_003068002.1 254560907 8192448 2373728..2377105 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2377105 8192448 METDI2463 Methylobacterium extorquens DM4 hypothetical protein YP_003068002.1 2373728 D 661410 CDS YP_003068003.1 254560908 8192449 2377206..2378654 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2378654 8192449 METDI2464 Methylobacterium extorquens DM4 hypothetical protein YP_003068003.1 2377206 D 661410 CDS YP_003068004.1 254560909 8192450 2378651..2379673 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2379673 8192450 METDI2465 Methylobacterium extorquens DM4 hypothetical protein YP_003068004.1 2378651 D 661410 CDS YP_003068005.1 254560910 8192451 2379798..2380268 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2380268 8192451 METDI2466 Methylobacterium extorquens DM4 hypothetical protein YP_003068005.1 2379798 D 661410 CDS YP_003068006.1 254560911 8192452 complement(2379807..2380193) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2380193 8192452 METDI2467 Methylobacterium extorquens DM4 hypothetical protein YP_003068006.1 2379807 R 661410 CDS YP_003068007.1 254560912 8192453 complement(2380402..2380953) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2380953 8192453 METDI2468 Methylobacterium extorquens DM4 hypothetical protein YP_003068007.1 2380402 R 661410 CDS YP_003068008.1 254560913 8192454 complement(2381024..2382292) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 14343156, 6272062; Product type e : enzyme; diaminopimelate decarboxylase 2382292 lysA 8192454 lysA Methylobacterium extorquens DM4 diaminopimelate decarboxylase YP_003068008.1 2381024 R 661410 CDS YP_003068009.1 254560914 8195656 complement(2382493..2382843) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2382843 8195656 METDI2470 Methylobacterium extorquens DM4 hypothetical protein YP_003068009.1 2382493 R 661410 CDS YP_003068010.1 254560915 8192455 complement(2382996..2383274) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2383274 8192455 METDI2471 Methylobacterium extorquens DM4 hypothetical protein YP_003068010.1 2382996 R 661410 CDS YP_003068011.1 254560916 8192456 complement(2383465..2384187) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2384187 8192456 METDI2472 Methylobacterium extorquens DM4 hypothetical protein YP_003068011.1 2383465 R 661410 CDS YP_003068012.1 254560917 8192457 complement(2384412..2385029) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2385029 8192457 METDI2473 Methylobacterium extorquens DM4 hypothetical protein YP_003068012.1 2384412 R 661410 CDS YP_003068013.1 254560918 8192458 complement(2385384..2386034) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; RNAse HII 2386034 rnhB 8192458 rnhB Methylobacterium extorquens DM4 RNAse HII YP_003068013.1 2385384 R 661410 CDS YP_003068014.1 254560919 8196004 complement(2386162..2387238) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative glycosyl transferase, group 1 2387238 8196004 METDI2476 Methylobacterium extorquens DM4 putative glycosyl transferase, group 1 YP_003068014.1 2386162 R 661410 CDS YP_003068015.1 254560920 8192459 complement(2387359..2388171) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2388171 8192459 METDI2477 Methylobacterium extorquens DM4 hypothetical protein YP_003068015.1 2387359 R 661410 CDS YP_003068016.1 254560921 8192460 2388834..2390042 1 NC_012988.1 Evidence 1c : Function experimentally demonstrated in the studied genus; Product type e : enzyme; serine-glyoxylate aminotransferase (SGAT) 2390042 sga 8192460 sga Methylobacterium extorquens DM4 serine-glyoxylate aminotransferase (SGAT) YP_003068016.1 2388834 D 661410 CDS YP_003068017.1 254560922 8196115 2390323..2391267 1 NC_012988.1 Evidence 1c : Function experimentally demonstrated in the studied genus; PubMedId : 12055310, 1657886; Product type e : enzyme; Hydroxypyruvate reductase, NAD(P)H-dependent 2391267 hprA 8196115 hprA Methylobacterium extorquens DM4 Hydroxypyruvate reductase, NAD(P)H-dependent YP_003068017.1 2390323 D 661410 CDS YP_003068018.1 254560923 8195574 2391411..2392277 1 NC_012988.1 Evidence 1c : Function experimentally demonstrated in the studied genus; Product type e : enzyme; NADP-dependent methylene-tetrahydromethanopterin/methylene- tetrahydrofolate dehydrogenase 2392277 mtdA 8195574 mtdA Methylobacterium extorquens DM4 NADP-dependent methylene-tetrahydromethanopterin/methylene- tetrahydrofolate dehydrogenase YP_003068018.1 2391411 D 661410 CDS YP_003068019.1 254560924 8195731 2392371..2392997 1 NC_012988.1 Evidence 1c : Function experimentally demonstrated in the studied genus; Product type e : enzyme; methenyl tetrahydrofolate cyclohydrolase 2392997 fch 8195731 fch Methylobacterium extorquens DM4 methenyl tetrahydrofolate cyclohydrolase YP_003068019.1 2392371 D 661410 CDS YP_003068020.1 254560925 8195358 2393446..2394618 1 NC_012988.1 catalyzes the formation of malyl-CoA from malate and CoA; malate--CoA ligase subunit beta 2394618 mtkA 8195358 mtkA Methylobacterium extorquens DM4 malate--CoA ligase subunit beta YP_003068020.1 2393446 D 661410 CDS YP_003068021.1 254560926 8195733 2394641..2395531 1 NC_012988.1 Catalyzes the only substrate-level phosphorylation in the TCA cycle; succinyl-CoA synthetase subunit alpha 2395531 mtkB 8195733 mtkB Methylobacterium extorquens DM4 succinyl-CoA synthetase subunit alpha YP_003068021.1 2394641 D 661410 CDS YP_003068022.1 254560927 8195734 2395731..2398499 1 NC_012988.1 Evidence 1c : Function experimentally demonstrated in the studied genus; Product type e : enzyme; phosphoenolpyruvate carboxylase 2398499 ppc 8195734 ppc Methylobacterium extorquens DM4 phosphoenolpyruvate carboxylase YP_003068022.1 2395731 D 661410 CDS YP_003068023.1 254560928 8195881 2398687..2399661 1 NC_012988.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15188393, 16856937, 16926146, 17548827; Product type e : enzyme; malyl-CoA lyase/beta-methylmalyl-CoA lyase 2399661 mcl 8195881 mcl Methylobacterium extorquens DM4 malyl-CoA lyase/beta-methylmalyl-CoA lyase YP_003068023.1 2398687 D 661410 CDS YP_003068024.1 254560929 8195667 complement(2399731..2400297) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2400297 8195667 METDI2486 Methylobacterium extorquens DM4 hypothetical protein YP_003068024.1 2399731 R 661410 CDS YP_003068025.1 254560930 8192461 2400593..2401468 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative carboxymethylenebutenolidase precursor (dienelactone hydrolase) (tat pathway signal) 2401468 8192461 METDI2487 Methylobacterium extorquens DM4 putative carboxymethylenebutenolidase precursor (dienelactone hydrolase) (tat pathway signal) YP_003068025.1 2400593 D 661410 CDS YP_003068026.1 254560931 8192462 complement(2401476..2401853) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative transcriptional coactivator/pterin dehydratase 2401853 8192462 METDI2488 Methylobacterium extorquens DM4 putative transcriptional coactivator/pterin dehydratase YP_003068026.1 2401476 R 661410 CDS YP_003068027.1 254560932 8192463 2402080..2403075 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type t : transporter; ABC transporter substrate binding protein (subunit A) 2403075 8192463 METDI2489 Methylobacterium extorquens DM4 ABC transporter substrate binding protein (subunit A) YP_003068027.1 2402080 D 661410 CDS YP_003068028.1 254560933 8192464 2403115..2403849 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type t : transporter; ABC transporter permease component (subunit B) 2403849 8192464 METDI2490 Methylobacterium extorquens DM4 ABC transporter permease component (subunit B) YP_003068028.1 2403115 D 661410 CDS YP_003068029.1 254560934 8192465 2403830..2404603 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type t : transporter; ABC transporter ATP-binding protein (subunit C) 2404603 8192465 METDI2491 Methylobacterium extorquens DM4 ABC transporter ATP-binding protein (subunit C) YP_003068029.1 2403830 D 661410 CDS YP_003068030.1 254560935 8192466 2405310..2407115 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative PQQ-linked dehydrogenase precursor 2407115 8192466 METDI2492 Methylobacterium extorquens DM4 putative PQQ-linked dehydrogenase precursor YP_003068030.1 2405310 D 661410 CDS YP_003068031.1 254560936 8192467 2407270..2407860 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 1657873; Product type c : carrier; cytochrome c 2407860 8192467 METDI2493 Methylobacterium extorquens DM4 cytochrome c YP_003068031.1 2407270 D 661410 CDS YP_003068032.1 254560937 8192468 2407860..2408714 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative XoxJ-and MxaJ-like protein precursor 2408714 8192468 METDI2494 Methylobacterium extorquens DM4 putative XoxJ-and MxaJ-like protein precursor YP_003068032.1 2407860 D 661410 CDS YP_003068033.1 254560938 8192469 complement(2408820..2409296) 1 NC_012988.1 Evidence 1c : Function experimentally demonstrated in the studied genus; PubMedId : 12730156, 9168622; Product type e : enzyme; 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase (7, 8-dihydro-6-hydroxymethylpterin-pyrophosphokinase, 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, PPPK) 2409296 folK 8192469 folK Methylobacterium extorquens DM4 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase (7, 8-dihydro-6-hydroxymethylpterin-pyrophosphokinase, 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, PPPK) YP_003068033.1 2408820 R 661410 CDS YP_003068034.1 254560939 8195438 complement(2409293..2409685) 1 NC_012988.1 Evidence 1c : Function experimentally demonstrated in the studied genus; PubMedId : 12730156, 9168622; Product type e : enzyme; dihydroneopterin aldolase 2409685 folB 8195438 folB Methylobacterium extorquens DM4 dihydroneopterin aldolase YP_003068034.1 2409293 R 661410 CDS YP_003068035.1 254560940 8195435 complement(2409678..2410547) 1 NC_012988.1 Evidence 1c : Function experimentally demonstrated in the studied genus; PubMedId : 12730156, 9168622; Product type e : enzyme; 7,8-dihydropteroate synthase (dihydropteroate synthase (DHPS), dihydropteroate pyrophosphorylase) 2410547 folP 8195435 folP Methylobacterium extorquens DM4 7,8-dihydropteroate synthase (dihydropteroate synthase (DHPS), dihydropteroate pyrophosphorylase) YP_003068035.1 2409678 R 661410 CDS YP_003068036.1 254560941 8195439 complement(2410642..2411007) 1 NC_012988.1 Evidence 1c : Function experimentally demonstrated in the studied genus; PubMedId : 9168622; Product type f : factor; Orf3, putative exported protein 2411007 8195439 METDI2498 Methylobacterium extorquens DM4 Orf3, putative exported protein YP_003068036.1 2410642 R 661410 CDS YP_003068037.1 254560942 8192470 complement(2410988..2411722) 1 NC_012988.1 Evidence 1c : Function experimentally demonstrated in the studied genus; PubMedId : 9168622; Product type f : factor; Orf4 2411722 8192470 METDI2499 Methylobacterium extorquens DM4 Orf4 YP_003068037.1 2410988 R 661410 CDS YP_003068038.1 254560943 8192471 complement(2411719..2412873) 1 NC_012988.1 Evidence 1c : Function experimentally demonstrated in the studied genus; Product type e : enzyme; pyrroloquinoline quinone biosynthesis protein PqqE 2412873 pqqE 8192471 pqqE Methylobacterium extorquens DM4 pyrroloquinoline quinone biosynthesis protein PqqE YP_003068038.1 2411719 R 661410 CDS YP_003068039.1 254560944 8195891 complement(2412870..2413970) 1 NC_012988.1 Required in the synthesis of PPQ, but its exact function is unknown; pyrroloquinoline quinone biosynthesis protein PqqC 2413970 pqqCD 8195891 pqqCD Methylobacterium extorquens DM4 pyrroloquinoline quinone biosynthesis protein PqqC YP_003068039.1 2412870 R 661410 CDS YP_003068040.1 254560945 8195890 complement(2414137..2415036) 1 NC_012988.1 possibly involved in transport of pyrroloquinoline quinone transport; pyrroloquinoline quinone biosynthesis protein PqqB 2415036 pqqB 8195890 pqqB Methylobacterium extorquens DM4 pyrroloquinoline quinone biosynthesis protein PqqB YP_003068040.1 2414137 R 661410 CDS YP_003068041.1 254560946 8195889 complement(2415084..2415173) 1 NC_012988.1 Required for coenzyme pyrroloquinoline quinone (PQQ) biosynthesis; probably provides the glutamate and tyrosine residues that are cross-linked and modified to form the coenzyme; coenzyme PQQ synthesis protein PqqA 2415173 pqqA 8195889 pqqA Methylobacterium extorquens DM4 coenzyme PQQ synthesis protein PqqA YP_003068041.1 2415084 R 661410 CDS YP_003068042.1 254560947 8195887 complement(2415508..2416215) 1 NC_012988.1 Evidence 1c : Function experimentally demonstrated in the studied genus; Product type r : regulator; two-component transcriptional regulator, response regulator 2416215 mxbM 8195887 mxbM Methylobacterium extorquens DM4 two-component transcriptional regulator, response regulator YP_003068042.1 2415508 R 661410 CDS YP_003068043.1 254560948 8195764 complement(2416212..2417849) 1 NC_012988.1 Evidence 1c : Function experimentally demonstrated in the studied genus; Product type r : regulator; two-component transcriptional regulator, sensor kinase 2417849 mxbD 8195764 mxbD Methylobacterium extorquens DM4 two-component transcriptional regulator, sensor kinase YP_003068043.1 2416212 R 661410 CDS YP_003068044.1 254560949 8195763 complement(2417958..2418164) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2418164 8195763 METDI2506 Methylobacterium extorquens DM4 hypothetical protein YP_003068044.1 2417958 R 661410 CDS YP_003068045.1 254560950 8192472 complement(2418312..2419109) 1 NC_012988.1 Evidence 1c : Function experimentally demonstrated in the studied genus; Product type e : enzyme; formyltransferase/hydrolase complex Fhc subunit C 2419109 fhcC 8192472 fhcC Methylobacterium extorquens DM4 formyltransferase/hydrolase complex Fhc subunit C YP_003068045.1 2418312 R 661410 CDS YP_003068046.1 254560951 8195375 complement(2419106..2420041) 1 NC_012988.1 catalyzes the transfer of a formyl group from formylmethanofuran to tetrahydromethanopterin tetrahydromethanopterin; formylmethanofuran--tetrahydromethanopterin formyltransferase 2420041 fhcD 8195375 fhcD Methylobacterium extorquens DM4 formylmethanofuran--tetrahydromethanopterin formyltransferase YP_003068046.1 2419106 R 661410 CDS YP_003068047.1 254560952 8195376 complement(2420067..2421713) 1 NC_012988.1 Evidence 1c : Function experimentally demonstrated in the studied genus; Product type e : enzyme; formyltransferase/hydrolase complex Fhc subunit A 2421713 fhcA 8195376 fhcA Methylobacterium extorquens DM4 formyltransferase/hydrolase complex Fhc subunit A YP_003068047.1 2420067 R 661410 CDS YP_003068048.1 254560953 8195373 complement(2421707..2422795) 1 NC_012988.1 Evidence 1c : Function experimentally demonstrated in the studied genus; Product type e : enzyme; Formyltransferase/hydrolase complex Fhc subunit B 2422795 fhcB 8195373 fhcB Methylobacterium extorquens DM4 Formyltransferase/hydrolase complex Fhc subunit B YP_003068048.1 2421707 R 661410 CDS YP_003068049.1 254560954 8195374 2423224..2424222 1 NC_012988.1 Evidence 1c : Function experimentally demonstrated in the studied genus; Product type e : enzyme; ribofuranosylaminobenzene 5'-phosphate (RFAP) synthase 2424222 mptG 8195374 mptG Methylobacterium extorquens DM4 ribofuranosylaminobenzene 5'-phosphate (RFAP) synthase YP_003068049.1 2423224 D 661410 CDS YP_003068050.1 254560955 8195720 2424333..2425226 1 NC_012988.1 Evidence 1c : Function experimentally demonstrated in the studied genus; Product type e : enzyme; NAD(P)-dependent methylene tetrahydromethanopterin dehydrogenase 2425226 mtdB 8195720 mtdB Methylobacterium extorquens DM4 NAD(P)-dependent methylene tetrahydromethanopterin dehydrogenase YP_003068050.1 2424333 D 661410 CDS YP_003068051.1 254560956 8195732 2425337..2426461 1 NC_012988.1 Evidence 1c : Function experimentally demonstrated in the studied genus; hypothetical protein 2426461 8195732 METDI2514 Methylobacterium extorquens DM4 hypothetical protein YP_003068051.1 2425337 D 661410 CDS YP_003068052.1 254560957 8192473 2426391..2427362 1 NC_012988.1 catalyzes the reversible formation of methenyl-H(4)methanopterin from N(5)-formyl-H(4)methanopterin; N(5),N(10)-methenyltetrahydromethanopterin cyclohydrolase 2427362 mch 8192473 mch Methylobacterium extorquens DM4 N(5),N(10)-methenyltetrahydromethanopterin cyclohydrolase YP_003068052.1 2426391 D 661410 CDS YP_003068053.1 254560958 8195666 2427637..2428551 1 NC_012988.1 Evidence 1c : Function experimentally demonstrated in the studied genus; Product type e : enzyme; hypothetical protein 2428551 8195666 METDI2516 Methylobacterium extorquens DM4 hypothetical protein YP_003068053.1 2427637 D 661410 CDS YP_003068054.1 254560959 8192474 2428548..2429417 1 NC_012988.1 Evidence 1c : Function experimentally demonstrated in the studied genus; Product type e : enzyme; hypothetical protein 2429417 8192474 METDI2517 Methylobacterium extorquens DM4 hypothetical protein YP_003068054.1 2428548 D 661410 CDS YP_003068055.1 254560960 8192475 2429675..2430187 1 NC_012988.1 Evidence 1c : Function experimentally demonstrated in the studied genus; PubMedId : 15632161; Product type e : enzyme; formaldehyde-activating enzyme 2430187 fae 8192475 fae Methylobacterium extorquens DM4 formaldehyde-activating enzyme YP_003068055.1 2429675 D 661410 CDS YP_003068056.1 254560961 8195354 complement(2430327..2431022) 1 NC_012988.1 Evidence 1c : Function experimentally demonstrated in the studied genus; PubMedId : 12055310; Product type e : enzyme; conserved HisA-related protein (Orf17) involved in tetrahydromethanopterin-dependent formaldehyde oxidation 2431022 8195354 METDI2519 Methylobacterium extorquens DM4 conserved HisA-related protein (Orf17) involved in tetrahydromethanopterin-dependent formaldehyde oxidation YP_003068056.1 2430327 R 661410 CDS YP_003068057.1 254560962 8192476 2431026..2432060 1 NC_012988.1 Evidence 1c : Function experimentally demonstrated in the studied genus; Product type e : enzyme; hypothetical protein 2432060 8192476 METDI2520 Methylobacterium extorquens DM4 hypothetical protein YP_003068057.1 2431026 D 661410 CDS YP_003068058.1 254560963 8192477 complement(2432315..2433415) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pf : putative factor; Conserved MxaE-like protein of unknown function 2433415 8192477 METDI2522 Methylobacterium extorquens DM4 Conserved MxaE-like protein of unknown function YP_003068058.1 2432315 R 661410 CDS YP_003068059.1 254560964 8192478 complement(2433441..2433971) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pf : putative factor; Conserved MxaD-like protein precursor of unknown function 2433971 8192478 METDI2523 Methylobacterium extorquens DM4 Conserved MxaD-like protein precursor of unknown function YP_003068059.1 2433441 R 661410 CDS YP_003068060.1 254560965 8192479 complement(2434037..2434591) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pf : putative factor; Conserved MxaD-like protein precursor of unknown function 2434591 8192479 METDI2524 Methylobacterium extorquens DM4 Conserved MxaD-like protein precursor of unknown function YP_003068060.1 2434037 R 661410 CDS YP_003068061.1 254560966 8192480 complement(2434612..2435208) 1 NC_012988.1 Evidence 1c : Function experimentally demonstrated in the studied genus; Product type e : enzyme; hypothetical protein 2435208 8192480 METDI2525 Methylobacterium extorquens DM4 hypothetical protein YP_003068061.1 2434612 R 661410 CDS YP_003068062.1 254560967 8192481 complement(2435266..2436840) 1 NC_012988.1 Evidence 1c : Function experimentally demonstrated in the studied genus; Product type e : enzyme; hypothetical protein 2436840 8192481 METDI2526 Methylobacterium extorquens DM4 hypothetical protein YP_003068062.1 2435266 R 661410 CDS YP_003068063.1 254560968 8192482 complement(2436837..2437460) 1 NC_012988.1 Evidence 1c : Function experimentally demonstrated in the studied genus; Product type e : enzyme; hypothetical protein 2437460 8192482 METDI2527 Methylobacterium extorquens DM4 hypothetical protein YP_003068063.1 2436837 R 661410 CDS YP_003068064.1 254560969 8192483 complement(2437457..2438167) 1 NC_012988.1 Evidence 1c : Function experimentally demonstrated in the studied genus; Product type e : enzyme; hypothetical protein 2438167 8192483 METDI2528 Methylobacterium extorquens DM4 hypothetical protein YP_003068064.1 2437457 R 661410 CDS YP_003068065.1 254560970 8192484 complement(2438213..2438734) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2438734 8192484 METDI2529 Methylobacterium extorquens DM4 hypothetical protein YP_003068065.1 2438213 R 661410 CDS YP_003068066.1 254560971 8192485 2438967..2440235 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2440235 8192485 METDI2530 Methylobacterium extorquens DM4 hypothetical protein YP_003068066.1 2438967 D 661410 CDS YP_003068067.1 254560972 8192486 2440402..2441388 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2441388 8192486 METDI2531 Methylobacterium extorquens DM4 hypothetical protein YP_003068067.1 2440402 D 661410 CDS YP_003068068.1 254560973 8192487 2441480..2441914 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2441914 8192487 METDI2532 Methylobacterium extorquens DM4 hypothetical protein YP_003068068.1 2441480 D 661410 CDS YP_003068069.1 254560974 8192488 2441928..2442206 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2442206 8192488 METDI2533 Methylobacterium extorquens DM4 hypothetical protein YP_003068069.1 2441928 D 661410 CDS YP_003068070.1 254560975 8192489 2442203..2442952 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative ABC transporter, ATPase 2442952 8192489 METDI2534 Methylobacterium extorquens DM4 putative ABC transporter, ATPase YP_003068070.1 2442203 D 661410 CDS YP_003068071.1 254560976 8192490 2442949..2443842 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; hypothetical protein 2443842 8192490 METDI2535 Methylobacterium extorquens DM4 hypothetical protein YP_003068071.1 2442949 D 661410 CDS YP_003068072.1 254560977 8192491 2443853..2444482 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2444482 8192491 METDI2536 Methylobacterium extorquens DM4 hypothetical protein YP_003068072.1 2443853 D 661410 CDS YP_003068073.1 254560978 8192492 2445024..2447543 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type prc : putative receptor; putative TonB-dependent receptor:IMP dehydrogenase/GMP reductase precursor 2447543 8192492 METDI2538 Methylobacterium extorquens DM4 putative TonB-dependent receptor:IMP dehydrogenase/GMP reductase precursor YP_003068073.1 2445024 D 661410 CDS YP_003068074.1 254560979 8192493 2447861..2448262 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2448262 8192493 METDI2539 Methylobacterium extorquens DM4 hypothetical protein YP_003068074.1 2447861 D 661410 CDS YP_003068075.1 254560980 8192494 2448465..2448824 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 2448824 8192494 METDI2540 Methylobacterium extorquens DM4 hypothetical protein YP_003068075.1 2448465 D 661410 CDS YP_003068076.1 254560981 8192495 complement(2448928..2450475) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type e : enzyme; putative glycosyl transferase 2450475 8192495 METDI2541 Methylobacterium extorquens DM4 putative glycosyl transferase YP_003068076.1 2448928 R 661410 CDS YP_003068077.1 254560982 8192496 complement(2450607..2451866) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type e : enzyme; glycosyl transferase 2451866 8192496 METDI2542 Methylobacterium extorquens DM4 glycosyl transferase YP_003068077.1 2450607 R 661410 CDS YP_003068078.1 254560983 8192497 complement(2452039..2452617) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative polysaccharide export protein 2452617 8192497 METDI2543 Methylobacterium extorquens DM4 putative polysaccharide export protein YP_003068078.1 2452039 R 661410 CDS YP_003068079.1 254560984 8192498 2452838..2455252 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative succinoglycan biosynthesis transport protein exoP 2455252 8192498 METDI2544 Methylobacterium extorquens DM4 putative succinoglycan biosynthesis transport protein exoP YP_003068079.1 2452838 D 661410 CDS YP_003068080.1 254560985 8192499 complement(2455289..2455423) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2455423 8192499 METDI2545 Methylobacterium extorquens DM4 hypothetical protein YP_003068080.1 2455289 R 661410 CDS YP_003068081.1 254560986 8192500 complement(2455807..2456130) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 15322138, 1698765, 2674903; hypothetical protein 2456130 8192500 METDI2546 Methylobacterium extorquens DM4 hypothetical protein YP_003068081.1 2455807 R 661410 CDS YP_003068082.1 254560987 8192501 complement(2456221..2458101) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; DNA polymerase III, tau and gamma subunits 2458101 dnaX 8192501 dnaX Methylobacterium extorquens DM4 DNA polymerase III, tau and gamma subunits YP_003068082.1 2456221 R 661410 CDS YP_003068083.1 254560988 8195311 2458358..2458846 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2458846 8195311 METDI2548 Methylobacterium extorquens DM4 hypothetical protein YP_003068083.1 2458358 D 661410 CDS YP_003068084.1 254560989 8192502 complement(2458881..2459141) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2459141 8192502 METDI2549 Methylobacterium extorquens DM4 hypothetical protein YP_003068084.1 2458881 R 661410 CDS YP_003068085.1 254560990 8192504 2460335..2462083 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative recombinase 2462083 8192504 METDI2551 Methylobacterium extorquens DM4 putative recombinase YP_003068085.1 2460335 D 661410 CDS YP_003068086.1 254560991 8192505 2462304..2463188 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2463188 8192505 METDI2553 Methylobacterium extorquens DM4 hypothetical protein YP_003068086.1 2462304 D 661410 CDS YP_003068087.1 254560992 8192506 2463469..2464428 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2464428 8192506 METDI2554 Methylobacterium extorquens DM4 hypothetical protein YP_003068087.1 2463469 D 661410 CDS YP_003068088.1 254560993 8192507 2464428..2464595 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2464595 8192507 METDI2555 Methylobacterium extorquens DM4 hypothetical protein YP_003068088.1 2464428 D 661410 CDS YP_003068089.1 254560994 8192508 2464592..2465125 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2465125 8192508 METDI2556 Methylobacterium extorquens DM4 hypothetical protein YP_003068089.1 2464592 D 661410 CDS YP_003068090.1 254560995 8192509 2465177..2465455 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2465455 8192509 METDI2557 Methylobacterium extorquens DM4 hypothetical protein YP_003068090.1 2465177 D 661410 CDS YP_003068091.1 254560996 8192510 complement(2466281..2467339) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2467339 8192510 MEDTI5948 Methylobacterium extorquens DM4 hypothetical protein YP_003068091.1 2466281 R 661410 CDS YP_003068092.1 254560997 8190530 complement(2467490..2468038) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative resolvase 2468038 8190530 METDI2559 Methylobacterium extorquens DM4 putative resolvase YP_003068092.1 2467490 R 661410 CDS YP_003068093.1 254560998 8192511 complement(2468245..2470005) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2470005 8192511 MEDTI5949 Methylobacterium extorquens DM4 hypothetical protein YP_003068093.1 2468245 R 661410 CDS YP_003068094.1 254560999 8190531 complement(2470109..2471824) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative site-specific DNA methyltransferase 2471824 8190531 METDI2560 Methylobacterium extorquens DM4 putative site-specific DNA methyltransferase YP_003068094.1 2470109 R 661410 CDS YP_003068095.1 254561000 8192512 2472351..2472590 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2472590 8192512 METDI2561 Methylobacterium extorquens DM4 hypothetical protein YP_003068095.1 2472351 D 661410 CDS YP_003068096.1 254561001 8192513 complement(2472987..2473517) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2473517 8192513 METDI2562 Methylobacterium extorquens DM4 hypothetical protein YP_003068096.1 2472987 R 661410 CDS YP_003068097.1 254561002 8192514 2473739..2473981 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2473981 8192514 METDI2563 Methylobacterium extorquens DM4 hypothetical protein YP_003068097.1 2473739 D 661410 CDS YP_003068098.1 254561003 8192515 2474041..2474328 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2474328 8192515 METDI2564 Methylobacterium extorquens DM4 hypothetical protein YP_003068098.1 2474041 D 661410 CDS YP_003068099.1 254561004 8192516 2474416..2475039 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2475039 8192516 METDI2565 Methylobacterium extorquens DM4 hypothetical protein YP_003068099.1 2474416 D 661410 CDS YP_003068100.1 254561005 8192517 2475169..2475498 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2475498 8192517 METDI2566 Methylobacterium extorquens DM4 hypothetical protein YP_003068100.1 2475169 D 661410 CDS YP_003068101.1 254561006 8192518 2475613..2476194 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2476194 8192518 METDI2567 Methylobacterium extorquens DM4 hypothetical protein YP_003068101.1 2475613 D 661410 CDS YP_003068102.1 254561007 8196236 2477164..2478210 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2478210 8196236 MEDTI5950 Methylobacterium extorquens DM4 hypothetical protein YP_003068102.1 2477164 D 661410 CDS YP_003068103.1 254561008 8190532 complement(2478314..2479420) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative AFG1-family ATPase 2479420 8190532 METDI2569 Methylobacterium extorquens DM4 putative AFG1-family ATPase YP_003068103.1 2478314 R 661410 CDS YP_003068104.1 254561009 8192520 2479684..2479878 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2479878 8192520 MEDTI5951 Methylobacterium extorquens DM4 hypothetical protein YP_003068104.1 2479684 D 661410 CDS YP_003068105.1 254561010 8190533 2480364..2482007 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative transporter, major facilitator superfamily; putative oxalate/formate antiporter 2482007 8190533 METDI2570 Methylobacterium extorquens DM4 putative transporter, major facilitator superfamily; putative oxalate/formate antiporter YP_003068105.1 2480364 D 661410 CDS YP_003068106.1 254561011 8192521 2482333..2483085 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2483085 8192521 METDI2572 Methylobacterium extorquens DM4 hypothetical protein YP_003068106.1 2482333 D 661410 CDS YP_003068107.1 254561012 8192522 2483348..2483614 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2483614 8192522 METDI2574 Methylobacterium extorquens DM4 hypothetical protein YP_003068107.1 2483348 D 661410 CDS YP_003068108.1 254561013 8192523 2483731..2484207 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2484207 8192523 METDI2575 Methylobacterium extorquens DM4 hypothetical protein YP_003068108.1 2483731 D 661410 CDS YP_003068109.1 254561014 8192524 2484648..2486183 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative DNA mismatch repair protein 2486183 8192524 METDI2576 Methylobacterium extorquens DM4 putative DNA mismatch repair protein YP_003068109.1 2484648 D 661410 CDS YP_003068110.1 254561015 8192525 2486180..2487718 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative DNA mismatch repair protein 2487718 8192525 METDI2577 Methylobacterium extorquens DM4 putative DNA mismatch repair protein YP_003068110.1 2486180 D 661410 CDS YP_003068111.1 254561016 8192526 2488481..2488687 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2488687 8192526 METDI2579 Methylobacterium extorquens DM4 hypothetical protein YP_003068111.1 2488481 D 661410 CDS YP_003068112.1 254561017 8192527 complement(2488928..2491264) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2491264 8192527 METDI2580 Methylobacterium extorquens DM4 hypothetical protein YP_003068112.1 2488928 R 661410 CDS YP_003068113.1 254561018 8192528 complement(2491261..2491638) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2491638 8192528 METDI2581 Methylobacterium extorquens DM4 hypothetical protein YP_003068113.1 2491261 R 661410 CDS YP_003068114.1 254561019 8192529 2492290..2492991 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative partitioning protein, putative ATPase 2492991 8192529 METDI2582 Methylobacterium extorquens DM4 putative partitioning protein, putative ATPase YP_003068114.1 2492290 D 661410 CDS YP_003068115.1 254561020 8192530 2492988..2493398 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2493398 8192530 METDI2583 Methylobacterium extorquens DM4 hypothetical protein YP_003068115.1 2492988 D 661410 CDS YP_003068116.1 254561021 8192531 complement(2493475..2494719) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 10613878, 18433868; Product type f : factor; replication initiation protein RepC 2494719 8192531 METDI2584 Methylobacterium extorquens DM4 replication initiation protein RepC YP_003068116.1 2493475 R 661410 CDS YP_003068117.1 254561022 8192532 2495104..2495337 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcriptional regulator 2495337 8192532 METDI2585 Methylobacterium extorquens DM4 putative transcriptional regulator YP_003068117.1 2495104 D 661410 CDS YP_003068118.1 254561023 8192533 2495447..2495818 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcriptional regulator 2495818 8192533 METDI2586 Methylobacterium extorquens DM4 putative transcriptional regulator YP_003068118.1 2495447 D 661410 CDS YP_003068119.1 254561024 8192534 complement(2495841..2496047) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pf : putative factor; hypothetical protein 2496047 8192534 MEDTI5952 Methylobacterium extorquens DM4 hypothetical protein YP_003068119.1 2495841 R 661410 CDS YP_003068120.1 254561025 8190534 complement(2496182..2496514) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor; putative single-strand binding protein/primosomal replication protein 2496514 8190534 METDI2587 Methylobacterium extorquens DM4 putative single-strand binding protein/primosomal replication protein YP_003068120.1 2496182 R 661410 CDS YP_003068121.1 254561026 8192535 complement(2497115..2498278) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 10613878, 18433868; Product type f : factor; replication initiation protein RepC 2498278 repC 8192535 repC Methylobacterium extorquens DM4 replication initiation protein RepC YP_003068121.1 2497115 R 661410 CDS YP_003068122.1 254561027 8195036 complement(2498541..2499539) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 10613878, 18433868; Product type f : factor; replication protein B 2499539 repB 8195036 repB Methylobacterium extorquens DM4 replication protein B YP_003068122.1 2498541 R 661410 CDS YP_003068123.1 254561028 8195980 complement(2499521..2500675) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 12383728, 18433868; Product type f : factor; replication protein A 2500675 repA 8195980 repA Methylobacterium extorquens DM4 replication protein A YP_003068123.1 2499521 R 661410 CDS YP_003068124.1 254561029 8195979 complement(2500951..2502123) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; integrase/recombinase protein 2502123 8195979 METDI2591 Methylobacterium extorquens DM4 integrase/recombinase protein YP_003068124.1 2500951 R 661410 CDS YP_003068125.1 254561030 8192536 complement(2502137..2503225) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2503225 8192536 METDI2592 Methylobacterium extorquens DM4 hypothetical protein YP_003068125.1 2502137 R 661410 CDS YP_003068126.1 254561031 8192537 complement(2503222..2503659) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; plasmid stability protein 2503659 8192537 METDI2593 Methylobacterium extorquens DM4 plasmid stability protein YP_003068126.1 2503222 R 661410 CDS YP_003068127.1 254561032 8192538 complement(2503656..2503934) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor; putative prevent-host-death family protein, putative antitoxin of toxin-antitoxin system 2503934 8192538 METDI2594 Methylobacterium extorquens DM4 putative prevent-host-death family protein, putative antitoxin of toxin-antitoxin system YP_003068127.1 2503656 R 661410 CDS YP_003068128.1 254561033 8192539 2504056..2504355 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor; putative prevent-host-death family protein 2504355 8192539 METDI2595 Methylobacterium extorquens DM4 putative prevent-host-death family protein YP_003068128.1 2504056 D 661410 CDS YP_003068129.1 254561034 8192540 2504902..2506023 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2506023 8192540 METDI2596 Methylobacterium extorquens DM4 hypothetical protein YP_003068129.1 2504902 D 661410 CDS YP_003068130.1 254561035 8192541 complement(2505901..2507145) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2507145 8192541 METDI2597 Methylobacterium extorquens DM4 hypothetical protein YP_003068130.1 2505901 R 661410 CDS YP_003068131.1 254561036 8192542 complement(2507142..2508020) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type f : factor; ATP-binding protein TniB 2508020 tniB 8192542 tniB Methylobacterium extorquens DM4 ATP-binding protein TniB YP_003068131.1 2507142 R 661410 CDS YP_003068132.1 254561037 8196202 complement(2508022..2509680) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; transposase of ISMdi29, ISNCY family 2509680 8196202 METDI2599 Methylobacterium extorquens DM4 transposase of ISMdi29, ISNCY family YP_003068132.1 2508022 R 661410 CDS YP_003068133.1 254561038 8192543 2509956..2510882 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2510882 8192543 METDI2601 Methylobacterium extorquens DM4 hypothetical protein YP_003068133.1 2509956 D 661410 CDS YP_003068134.1 254561039 8192544 2510882..2512393 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2512393 8192544 METDI2602 Methylobacterium extorquens DM4 hypothetical protein YP_003068134.1 2510882 D 661410 CDS YP_003068135.1 254561040 8192545 2512606..2513814 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative AAA ATPase 2513814 8192545 METDI2603 Methylobacterium extorquens DM4 putative AAA ATPase YP_003068135.1 2512606 D 661410 CDS YP_003068136.1 254561041 8192546 2513804..2516332 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2516332 8192546 METDI2604 Methylobacterium extorquens DM4 hypothetical protein YP_003068136.1 2513804 D 661410 CDS YP_003068137.1 254561042 8192547 2516450..2517640 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2517640 8192547 METDI2605 Methylobacterium extorquens DM4 hypothetical protein YP_003068137.1 2516450 D 661410 CDS YP_003068138.1 254561043 8192548 2517708..2518358 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2518358 8192548 METDI2606 Methylobacterium extorquens DM4 hypothetical protein YP_003068138.1 2517708 D 661410 CDS YP_003068139.1 254561044 8192549 2518364..2519320 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2519320 8192549 METDI2607 Methylobacterium extorquens DM4 hypothetical protein YP_003068139.1 2518364 D 661410 CDS YP_003068140.1 254561045 8192550 2520413..2520814 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative caspase-like protease 2520814 8192550 METDI2608 Methylobacterium extorquens DM4 putative caspase-like protease YP_003068140.1 2520413 D 661410 CDS YP_003068141.1 254561046 8192551 complement(2520875..2521213) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2521213 8192551 METDI2609 Methylobacterium extorquens DM4 hypothetical protein YP_003068141.1 2520875 R 661410 CDS YP_003068142.1 254561047 8192552 complement(2521291..2522187) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2522187 8192552 METDI2610 Methylobacterium extorquens DM4 hypothetical protein YP_003068142.1 2521291 R 661410 CDS YP_003068143.1 254561048 8192553 2522287..2522628 1 NC_012988.1 SohA; PrlF; involved in protein secretion; when overproduced or mutated, it induces growth defect and increased export of a reporter protein; a PrlF mutation induces the activity of the Lon protease, and a Lon-deficient strain suppresses the phenotype conferred by the PrlF mutation; putative regulator PrlF 2522628 8192553 METDI2611 Methylobacterium extorquens DM4 putative regulator PrlF YP_003068143.1 2522287 D 661410 CDS YP_003068144.1 254561049 8192554 2522625..2523128 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2523128 8192554 METDI2612 Methylobacterium extorquens DM4 hypothetical protein YP_003068144.1 2522625 D 661410 CDS YP_003068145.1 254561050 8192555 2523189..2523386 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2523386 8192555 METDI2613 Methylobacterium extorquens DM4 hypothetical protein YP_003068145.1 2523189 D 661410 CDS YP_003068146.1 254561051 8192556 2523456..2524157 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2524157 8192556 METDI2614 Methylobacterium extorquens DM4 hypothetical protein YP_003068146.1 2523456 D 661410 CDS YP_003068147.1 254561052 8192557 complement(2524546..2524857) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2524857 8192557 METDI2615 Methylobacterium extorquens DM4 hypothetical protein YP_003068147.1 2524546 R 661410 CDS YP_003068148.1 254561053 8192558 complement(2525518..2525736) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2525736 8192558 MEDTI5953 Methylobacterium extorquens DM4 hypothetical protein YP_003068148.1 2525518 R 661410 CDS YP_003068149.1 254561054 8190535 2525900..2527309 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 2882477; Product type e : enzyme; glutamine synthetase, type I 2527309 glnA 8190535 glnA Methylobacterium extorquens DM4 glutamine synthetase, type I YP_003068149.1 2525900 D 661410 CDS YP_003068150.1 254561055 8195496 complement(2527333..2528214) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2528214 8195496 METDI2617 Methylobacterium extorquens DM4 hypothetical protein YP_003068150.1 2527333 R 661410 CDS YP_003068151.1 254561056 8192559 complement(2528211..2529137) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor; putative conjugal transfer antirestriction protein 2529137 8192559 METDI2618 Methylobacterium extorquens DM4 putative conjugal transfer antirestriction protein YP_003068151.1 2528211 R 661410 CDS YP_003068152.1 254561057 8192560 complement(2529487..2530074) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2530074 8192560 METDI2619 Methylobacterium extorquens DM4 hypothetical protein YP_003068152.1 2529487 R 661410 CDS YP_003068153.1 254561058 8192561 complement(2530468..2530794) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2530794 8192561 METDI2621 Methylobacterium extorquens DM4 hypothetical protein YP_003068153.1 2530468 R 661410 CDS YP_003068154.1 254561059 8192562 complement(2530791..2531009) 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 2531009 8192562 METDI2622 Methylobacterium extorquens DM4 hypothetical protein YP_003068154.1 2530791 R 661410 CDS YP_003068155.1 254561060 8192563 complement(2531039..2531242) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2531242 8192563 METDI2623 Methylobacterium extorquens DM4 hypothetical protein YP_003068155.1 2531039 R 661410 CDS YP_003068156.1 254561061 8192564 complement(2531246..2532118) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2532118 8192564 METDI2624 Methylobacterium extorquens DM4 hypothetical protein YP_003068156.1 2531246 R 661410 CDS YP_003068157.1 254561062 8192565 complement(2532115..2532588) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2532588 8192565 METDI2625 Methylobacterium extorquens DM4 hypothetical protein YP_003068157.1 2532115 R 661410 CDS YP_003068158.1 254561063 8192566 complement(2532675..2534357) 1 NC_012988.1 ParB family; plasmid partitioning protein 2534357 8192566 METDI2626 Methylobacterium extorquens DM4 plasmid partitioning protein YP_003068158.1 2532675 R 661410 CDS YP_003068159.1 254561064 8192567 complement(2534608..2539704) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative DNA adenine methyltransferase; putative methylase and helicase domains 2539704 8192567 METDI2627 Methylobacterium extorquens DM4 putative DNA adenine methyltransferase; putative methylase and helicase domains YP_003068159.1 2534608 R 661410 CDS YP_003068160.1 254561065 8192568 complement(2539809..2540003) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2540003 8192568 METDI2628 Methylobacterium extorquens DM4 hypothetical protein YP_003068160.1 2539809 R 661410 CDS YP_003068161.1 254561066 8192569 complement(2540020..2540622) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2540622 8192569 METDI2629 Methylobacterium extorquens DM4 hypothetical protein YP_003068161.1 2540020 R 661410 CDS YP_003068162.1 254561067 8192570 complement(2540914..2541207) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2541207 8192570 METDI2630 Methylobacterium extorquens DM4 hypothetical protein YP_003068162.1 2540914 R 661410 CDS YP_003068163.1 254561068 8192571 complement(2541239..2541901) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2541901 8192571 METDI2631 Methylobacterium extorquens DM4 hypothetical protein YP_003068163.1 2541239 R 661410 CDS YP_003068164.1 254561069 8192572 complement(2541941..2543734) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2543734 8192572 METDI2632 Methylobacterium extorquens DM4 hypothetical protein YP_003068164.1 2541941 R 661410 CDS YP_003068165.1 254561070 8192573 complement(2543731..2544162) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2544162 8192573 METDI2633 Methylobacterium extorquens DM4 hypothetical protein YP_003068165.1 2543731 R 661410 CDS YP_003068166.1 254561071 8192574 complement(2544316..2544618) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2544618 8192574 METDI2634 Methylobacterium extorquens DM4 hypothetical protein YP_003068166.1 2544316 R 661410 CDS YP_003068167.1 254561072 8192575 complement(2544849..2545142) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2545142 8192575 METDI2635 Methylobacterium extorquens DM4 hypothetical protein YP_003068167.1 2544849 R 661410 CDS YP_003068168.1 254561073 8192576 complement(2545139..2545552) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2545552 8192576 METDI2636 Methylobacterium extorquens DM4 hypothetical protein YP_003068168.1 2545139 R 661410 CDS YP_003068169.1 254561074 8192577 complement(2545685..2546611) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2546611 8192577 METDI2637 Methylobacterium extorquens DM4 hypothetical protein YP_003068169.1 2545685 R 661410 CDS YP_003068170.1 254561075 8192578 complement(2546816..2546992) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2546992 8192578 METDI2638 Methylobacterium extorquens DM4 hypothetical protein YP_003068170.1 2546816 R 661410 CDS YP_003068171.1 254561076 8192579 complement(2547541..2548344) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2548344 8192579 METDI2640 Methylobacterium extorquens DM4 hypothetical protein YP_003068171.1 2547541 R 661410 CDS YP_003068172.1 254561077 8192580 complement(2548347..2549081) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2549081 8192580 METDI2641 Methylobacterium extorquens DM4 hypothetical protein YP_003068172.1 2548347 R 661410 CDS YP_003068173.1 254561078 8192581 complement(2549173..2549865) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 7665460, 8564363, 87194564, 89155423, 93368423; Product type t : transporter; ABC transporter, ATPase; molybdate transporter 2549865 modC 8192581 modC Methylobacterium extorquens DM4 ABC transporter, ATPase; molybdate transporter YP_003068173.1 2549173 R 661410 CDS YP_003068174.1 254561079 8195713 complement(2549906..2550574) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 3553151, 7665460, 8564363, 89155423, 90148107, 93368423; Product type t : transporter; ABC transporter, permease; molybdate transporter 2550574 modB 8195713 modB Methylobacterium extorquens DM4 ABC transporter, permease; molybdate transporter YP_003068174.1 2549906 R 661410 CDS YP_003068175.1 254561080 8195710 complement(2550590..2551414) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type t : transporter; ABC transporter, periplasmic protein; molybdate transporter 2551414 8195710 METDI2644 Methylobacterium extorquens DM4 ABC transporter, periplasmic protein; molybdate transporter YP_003068175.1 2550590 R 661410 CDS YP_003068176.1 254561081 8192582 2551651..2552604 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10564479; Product type pr : putative regulator; putative regulator; putative molybdate and DNA-binding domains, excisionase family protein 2552604 8192582 METDI2645 Methylobacterium extorquens DM4 putative regulator; putative molybdate and DNA-binding domains, excisionase family protein YP_003068176.1 2551651 D 661410 CDS YP_003068177.1 254561082 8192583 complement(2552812..2553660) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor; putative universal stress protein UspA 2553660 8192583 METDI2646 Methylobacterium extorquens DM4 putative universal stress protein UspA YP_003068177.1 2552812 R 661410 CDS YP_003068178.1 254561083 8192584 complement(2553672..2554958) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative sulfate transporter/antisigma-factor antagonist, major facilitator superfamily 2554958 8192584 METDI2647 Methylobacterium extorquens DM4 putative sulfate transporter/antisigma-factor antagonist, major facilitator superfamily YP_003068178.1 2553672 R 661410 CDS YP_003068179.1 254561084 8192587 complement(2557645..2558910) 1 NC_012988.1 Evidence 1a : Function experimentally demonstrated in the studied strain; PubMedId : 1938878, 9274009; Product type e : enzyme; transposase of IS1354, IS256 family 2558910 8192587 METDI2651 Methylobacterium extorquens DM4 transposase of IS1354, IS256 family YP_003068179.1 2557645 R 661410 CDS YP_003068180.1 254561085 8192590 2560108..2561211 1 NC_012988.1 Evidence 1a : Function experimentally demonstrated in the studied strain; PubMedId : 9274009; Product type e : enzyme; transposase of IS1357, IS701 family 2561211 8192590 METDI2654 Methylobacterium extorquens DM4 transposase of IS1357, IS701 family YP_003068180.1 2560108 D 661410 CDS YP_003068181.1 254561086 8192591 complement(2561469..2562266) 1 NC_012988.1 Evidence 1a : Function experimentally demonstrated in the studied strain; PubMedId : 1938878; Product type r : regulator; transcriptional repressor of DCM dehalogenase 2562266 dcmR 8192591 dcmR Methylobacterium extorquens DM4 transcriptional repressor of DCM dehalogenase YP_003068181.1 2561469 R 661410 CDS YP_003068182.1 254561087 8195277 2563050..2563823 1 NC_012988.1 Evidence 1a : Function experimentally demonstrated in the studied strain; PubMedId : 11238968, 2104602, 8206823; Product type e : enzyme; dichloromethane dehalogenase (DCM dehalogenase) 2563823 dcmA 8195277 dcmA Methylobacterium extorquens DM4 dichloromethane dehalogenase (DCM dehalogenase) YP_003068182.1 2563050 D 661410 CDS YP_003068183.1 254561088 8195276 2563926..2564987 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2564987 8195276 METDI2657 Methylobacterium extorquens DM4 hypothetical protein YP_003068183.1 2563926 D 661410 CDS YP_003068184.1 254561089 8192592 2565022..2565600 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2565600 8192592 METDI2658 Methylobacterium extorquens DM4 hypothetical protein YP_003068184.1 2565022 D 661410 CDS YP_003068185.1 254561090 8192593 complement(2565711..2566976) 1 NC_012988.1 Evidence 1a : Function experimentally demonstrated in the studied strain; PubMedId : 9274009; Product type e : enzyme; transposase of IS1354, IS256 family 2566976 8192593 METDI2659 Methylobacterium extorquens DM4 transposase of IS1354, IS256 family YP_003068185.1 2565711 R 661410 CDS YP_003068186.1 254561091 8192595 complement(2567488..2568453) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 1310791, 3174633; Product type e : enzyme; transposase of ISMdi13, IS256 family (ORF2) 2568453 8192595 METDI2661 Methylobacterium extorquens DM4 transposase of ISMdi13, IS256 family (ORF2) YP_003068186.1 2567488 R 661410 CDS YP_003068187.1 254561092 8192596 complement(2568405..2568770) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; transposase of ISMdi13, IS256 family (ORF1) 2568770 8192596 METDI2662 Methylobacterium extorquens DM4 transposase of ISMdi13, IS256 family (ORF1) YP_003068187.1 2568405 R 661410 CDS YP_003068188.1 254561093 8192598 complement(2569301..2570218) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative nitrilase/amidohydrolase 2570218 8192598 METDI2664 Methylobacterium extorquens DM4 putative nitrilase/amidohydrolase YP_003068188.1 2569301 R 661410 CDS YP_003068189.1 254561094 8192599 complement(2570346..2571059) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative glutathione S-transferase 2571059 8192599 METDI2665 Methylobacterium extorquens DM4 putative glutathione S-transferase YP_003068189.1 2570346 R 661410 CDS YP_003068190.1 254561095 8192600 complement(2571056..2572207) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative coenzyme A transferase; putative formyl-CoA transferase 2572207 8192600 METDI2666 Methylobacterium extorquens DM4 putative coenzyme A transferase; putative formyl-CoA transferase YP_003068190.1 2571056 R 661410 CDS YP_003068191.1 254561096 8192601 complement(2572757..2573125) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2573125 8192601 METDI2667 Methylobacterium extorquens DM4 hypothetical protein YP_003068191.1 2572757 R 661410 CDS YP_003068192.1 254561097 8192602 2573315..2574484 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2574484 8192602 METDI2668 Methylobacterium extorquens DM4 hypothetical protein YP_003068192.1 2573315 D 661410 CDS YP_003068193.1 254561098 8192603 complement(2575436..2576701) 1 NC_012988.1 catalyzes the formation of S-adenosyl-4-methylthionine-2-oxobutanoate and 7,8-diaminononanoate from S-adenosyl-L-methionine and 8-amino-7-oxononanoate; adenosylmethionine--8-amino-7-oxononanoate transaminase 2576701 8192603 METDI2670 Methylobacterium extorquens DM4 adenosylmethionine--8-amino-7-oxononanoate transaminase YP_003068193.1 2575436 R 661410 CDS YP_003068194.1 254561099 8192604 complement(2576698..2577330) 1 NC_012988.1 DTB synthetase; dethiobiotin synthase; involved in production of dethiobiotin from ATP and 7,8-diaminononanoate and carbon dioxide; contains magnesium; dithiobiotin synthetase 2577330 bioD 8192604 bioD Methylobacterium extorquens DM4 dithiobiotin synthetase YP_003068194.1 2576698 R 661410 CDS YP_003068195.1 254561100 8195143 complement(2577327..2578331) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative bifunctional enzyme, phosphoglycerate mutase and PLP-dependent aminotransferase domains 2578331 8195143 METDI2672 Methylobacterium extorquens DM4 putative bifunctional enzyme, phosphoglycerate mutase and PLP-dependent aminotransferase domains YP_003068195.1 2577327 R 661410 CDS YP_003068196.1 254561101 8192605 complement(2578741..2578917) 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 2578917 8192605 METDI2673 Methylobacterium extorquens DM4 hypothetical protein YP_003068196.1 2578741 R 661410 CDS YP_003068197.1 254561102 8192606 2579887..2580144 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 2580144 8192606 METDI2674 Methylobacterium extorquens DM4 hypothetical protein YP_003068197.1 2579887 D 661410 CDS YP_003068198.1 254561103 8192607 2580380..2580688 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 2580688 8192607 METDI2675 Methylobacterium extorquens DM4 hypothetical protein YP_003068198.1 2580380 D 661410 CDS YP_003068199.1 254561104 8192608 2581383..2581637 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2581637 8192608 METDI2676 Methylobacterium extorquens DM4 hypothetical protein YP_003068199.1 2581383 D 661410 CDS YP_003068200.1 254561105 8192609 complement(2581654..2581887) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2581887 8192609 METDI2677 Methylobacterium extorquens DM4 hypothetical protein YP_003068200.1 2581654 R 661410 CDS YP_003068201.1 254561106 8192610 complement(2582625..2582858) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2582858 8192610 METDI2679 Methylobacterium extorquens DM4 hypothetical protein YP_003068201.1 2582625 R 661410 CDS YP_003068202.1 254561107 8192611 complement(2582910..2583575) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2583575 8192611 METDI2680 Methylobacterium extorquens DM4 hypothetical protein YP_003068202.1 2582910 R 661410 CDS YP_003068203.1 254561108 8192612 complement(2584162..2585910) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2585910 8192612 METDI2682 Methylobacterium extorquens DM4 hypothetical protein YP_003068203.1 2584162 R 661410 CDS YP_003068204.1 254561109 8192614 2587552..2588160 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative glutathione S-transferase 2588160 8192614 METDI2685 Methylobacterium extorquens DM4 putative glutathione S-transferase YP_003068204.1 2587552 D 661410 CDS YP_003068205.1 254561110 8192615 2588338..2589534 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2589534 8192615 METDI2686 Methylobacterium extorquens DM4 hypothetical protein YP_003068205.1 2588338 D 661410 CDS YP_003068206.1 254561111 8192616 2589545..2590909 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative sensor and regulator, histidine kinase and CheY-like receiver domains 2590909 8192616 METDI2687 Methylobacterium extorquens DM4 putative sensor and regulator, histidine kinase and CheY-like receiver domains YP_003068206.1 2589545 D 661410 CDS YP_003068207.1 254561112 8192617 complement(2590932..2591255) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2591255 8192617 METDI2688 Methylobacterium extorquens DM4 hypothetical protein YP_003068207.1 2590932 R 661410 CDS YP_003068208.1 254561113 8192618 complement(2591568..2592236) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; transglutaminase family protein cysteine peptidase precursor 2592236 8192618 METDI2689 Methylobacterium extorquens DM4 transglutaminase family protein cysteine peptidase precursor YP_003068208.1 2591568 R 661410 CDS YP_003068209.1 254561114 8192619 2592480..2592899 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 15808744, 2985285; Product type e : enzyme; thioesterase/thiol ester dehydrase-isomerase domain protein 2592899 8192619 METDI2690 Methylobacterium extorquens DM4 thioesterase/thiol ester dehydrase-isomerase domain protein YP_003068209.1 2592480 D 661410 CDS YP_003068210.1 254561115 8192620 complement(2592935..2593840) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; alpha/beta hydrolase protein precursor 2593840 8192620 METDI2691 Methylobacterium extorquens DM4 alpha/beta hydrolase protein precursor YP_003068210.1 2592935 R 661410 CDS YP_003068211.1 254561116 8192621 complement(2593904..2594833) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2594833 8192621 METDI2692 Methylobacterium extorquens DM4 hypothetical protein YP_003068211.1 2593904 R 661410 CDS YP_003068212.1 254561117 8192622 2595057..2597237 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type e : enzyme; putative molybdopterin oxidoreductase 2597237 8192622 METDI2693 Methylobacterium extorquens DM4 putative molybdopterin oxidoreductase YP_003068212.1 2595057 D 661410 CDS YP_003068213.1 254561118 8192623 2597344..2598972 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type t : transporter; oligopeptide transport protein (ABC superfamily, atp_bind) 2598972 yejF 8192623 yejF Methylobacterium extorquens DM4 oligopeptide transport protein (ABC superfamily, atp_bind) YP_003068213.1 2597344 D 661410 CDS YP_003068214.1 254561119 8196362 2598976..2600196 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 9692190; Product type e : enzyme; phosphopentomutase 2600196 deoB 8196362 deoB Methylobacterium extorquens DM4 phosphopentomutase YP_003068214.1 2598976 D 661410 CDS YP_003068215.1 254561120 8195287 complement(2600485..2602137) 1 NC_012988.1 ChvD; in Agrobacterium tumefaciens, mutations in both Walker boxes were found to affect virulence; putative ABC transporter ATP-binding protein 2602137 8195287 METDI2696 Methylobacterium extorquens DM4 putative ABC transporter ATP-binding protein YP_003068215.1 2600485 R 661410 CDS YP_003068216.1 254561121 8192624 complement(2602362..2602640) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2602640 8192624 METDI2697 Methylobacterium extorquens DM4 hypothetical protein YP_003068216.1 2602362 R 661410 CDS YP_003068217.1 254561122 8192625 complement(2602651..2603526) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11406279, 9746353; Product type pe : putative enzyme; putative DNA/RNA non-specific endonuclease 2603526 8192625 METDI2698 Methylobacterium extorquens DM4 putative DNA/RNA non-specific endonuclease YP_003068217.1 2602651 R 661410 CDS YP_003068218.1 254561123 8192626 complement(2603534..2603788) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2603788 8192626 METDI2699 Methylobacterium extorquens DM4 hypothetical protein YP_003068218.1 2603534 R 661410 CDS YP_003068219.1 254561124 8192627 2604112..2606094 1 NC_012988.1 catalyzes the formation of 1-deoxy-D-xylulose 5-phosphate from pyruvate and D-glyceraldehyde 3-phosphate; 1-deoxy-D-xylulose-5-phosphate synthase 2606094 dxs 8192627 dxs Methylobacterium extorquens DM4 1-deoxy-D-xylulose-5-phosphate synthase YP_003068219.1 2604112 D 661410 CDS YP_003068220.1 254561125 8195321 2606285..2607328 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative dihydroflavonol-4-reductase (Dihydrokaempferol 4-reductase) 2607328 8195321 METDI2701 Methylobacterium extorquens DM4 putative dihydroflavonol-4-reductase (Dihydrokaempferol 4-reductase) YP_003068220.1 2606285 D 661410 CDS YP_003068221.1 254561126 8192628 2607325..2608224 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative phytoene synthase 2608224 8192628 METDI2702 Methylobacterium extorquens DM4 putative phytoene synthase YP_003068221.1 2607325 D 661410 CDS YP_003068222.1 254561127 8192629 2608221..2609072 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative phytoene synthase 2609072 8192629 METDI2703 Methylobacterium extorquens DM4 putative phytoene synthase YP_003068222.1 2608221 D 661410 CDS YP_003068223.1 254561128 8192630 2609072..2610373 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative oxidoreductase, putative amine oxidase 2610373 8192630 METDI2704 Methylobacterium extorquens DM4 putative oxidoreductase, putative amine oxidase YP_003068223.1 2609072 D 661410 CDS YP_003068224.1 254561129 8192631 2610418..2612421 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 9555026; Product type e : enzyme; squalene-hopene-cyclase 2612421 shc 8192631 shc Methylobacterium extorquens DM4 squalene-hopene-cyclase YP_003068224.1 2610418 D 661410 CDS YP_003068225.1 254561130 8196117 2612555..2613223 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pe : putative enzyme; hypothetical protein 2613223 8196117 METDI2706 Methylobacterium extorquens DM4 hypothetical protein YP_003068225.1 2612555 D 661410 CDS YP_003068226.1 254561131 8192632 complement(2613383..2614756) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 9079896; Product type e : enzyme; acyltransferase (wcbT-like, rkpG-like) 2614756 rkpG 8192632 rkpG Methylobacterium extorquens DM4 acyltransferase (wcbT-like, rkpG-like) YP_003068226.1 2613383 R 661410 CDS YP_003068227.1 254561132 8195998 complement(2614753..2622159) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16404952; Product type pe : putative enzyme; putative fatty acid synthase multidomain protein (rkpA-like; wcbR-like) 2622159 8195998 METDI2708 Methylobacterium extorquens DM4 putative fatty acid synthase multidomain protein (rkpA-like; wcbR-like) YP_003068227.1 2614753 R 661410 CDS YP_003068228.1 254561133 8192633 complement(2622357..2622686) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2622686 8192633 METDI2709 Methylobacterium extorquens DM4 hypothetical protein YP_003068228.1 2622357 R 661410 CDS YP_003068229.1 254561134 8192634 complement(2622679..2623983) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 9765575; Product type e : enzyme; UDP-glucose-6-dehydrogenase 2623983 ugdH 8192634 ugdH Methylobacterium extorquens DM4 UDP-glucose-6-dehydrogenase YP_003068229.1 2622679 R 661410 CDS YP_003068230.1 254561135 8196297 complement(2624083..2626236) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative glycosyl transferase 2626236 8196297 METDI2711 Methylobacterium extorquens DM4 putative glycosyl transferase YP_003068230.1 2624083 R 661410 CDS YP_003068231.1 254561136 8192635 complement(2626243..2627289) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2627289 8192635 METDI2712 Methylobacterium extorquens DM4 hypothetical protein YP_003068231.1 2626243 R 661410 CDS YP_003068232.1 254561137 8196269 complement(2627858..2629075) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11113128, 11274108, 11500368, 11919184, 8636101, 9651403; Product type pt : putative transporter; putative oxalate/formate antiporter 2629075 oxlT 8196269 oxlT Methylobacterium extorquens DM4 putative oxalate/formate antiporter YP_003068232.1 2627858 R 661410 CDS YP_003068233.1 254561138 8195819 2629775..2631157 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 3905806; Product type e : enzyme; ethanolamine ammonia-lyase, heavy chain 2631157 eutB 8195819 eutB Methylobacterium extorquens DM4 ethanolamine ammonia-lyase, heavy chain YP_003068233.1 2629775 D 661410 CDS YP_003068234.1 254561139 8195337 2631154..2631936 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 2197274; Product type pe : putative enzyme; putative ethanolamine ammonia-lyase light chain (eutC-like) 2631936 8195337 METDI2715 Methylobacterium extorquens DM4 putative ethanolamine ammonia-lyase light chain (eutC-like) YP_003068234.1 2631154 D 661410 CDS YP_003068235.1 254561140 8192637 2632382..2634112 1 NC_012988.1 catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis; dihydroxy-acid dehydratase 2634112 8192637 METDI2716 Methylobacterium extorquens DM4 dihydroxy-acid dehydratase YP_003068235.1 2632382 D 661410 CDS YP_003068236.1 254561141 8192638 2634132..2634986 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2634986 8192638 METDI2717 Methylobacterium extorquens DM4 hypothetical protein YP_003068236.1 2634132 D 661410 CDS YP_003068237.1 254561142 8192639 complement(2635018..2635812) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 3049539; Product type e : enzyme; Exodeoxyribonuclease III (Exonuclease III) (EXO III) (AP endonuclease VI) 2635812 xthA 8192639 xthA Methylobacterium extorquens DM4 Exodeoxyribonuclease III (Exonuclease III) (EXO III) (AP endonuclease VI) YP_003068237.1 2635018 R 661410 CDS YP_003068238.1 254561143 8196345 2635974..2636633 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2636633 8196345 METDI2719 Methylobacterium extorquens DM4 hypothetical protein YP_003068238.1 2635974 D 661410 CDS YP_003068239.1 254561144 8192640 complement(2636726..2638657) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10411265; Product type pe : putative enzyme; putative Propionate-CoA ligase (Propionyl-CoA synthetase) (prpE-like) 2638657 8192640 METDI2720 Methylobacterium extorquens DM4 putative Propionate-CoA ligase (Propionyl-CoA synthetase) (prpE-like) YP_003068239.1 2636726 R 661410 CDS YP_003068240.1 254561145 8192641 complement(2638874..2639050) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2639050 8192641 METDI2722 Methylobacterium extorquens DM4 hypothetical protein YP_003068240.1 2638874 R 661410 CDS YP_003068241.1 254561146 8192642 2639302..2639523 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2639523 8192642 METDI2723 Methylobacterium extorquens DM4 hypothetical protein YP_003068241.1 2639302 D 661410 CDS YP_003068242.1 254561147 8192643 complement(2639751..2639927) 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 2639927 8192643 METDI2724 Methylobacterium extorquens DM4 hypothetical protein YP_003068242.1 2639751 R 661410 CDS YP_003068243.1 254561148 8192644 2640229..2640726 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 10574791, 8117684; Product type e : enzyme; phosphoribosylaminoimidazole carboxylase = AIR carboxylase, catalytic subunit 2640726 purE 8192644 purE Methylobacterium extorquens DM4 phosphoribosylaminoimidazole carboxylase = AIR carboxylase, catalytic subunit YP_003068243.1 2640229 D 661410 CDS YP_003068244.1 254561149 8195933 2640744..2641856 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 10074353, 10569930, 8117684, 9797284; Product type e : enzyme; phosphoribosylaminoimidazole carboxylase = AIR carboxylase, CO(2)-fixing subunit 2641856 purK 8195933 purK Methylobacterium extorquens DM4 phosphoribosylaminoimidazole carboxylase = AIR carboxylase, CO(2)-fixing subunit YP_003068244.1 2640744 D 661410 CDS YP_003068245.1 254561150 8195936 2642244..2643104 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2643104 8195936 METDI2727 Methylobacterium extorquens DM4 hypothetical protein YP_003068245.1 2642244 D 661410 CDS YP_003068246.1 254561151 8192645 2643510..2643890 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type r : regulator; response regulator receiver 2643890 8192645 METDI2728 Methylobacterium extorquens DM4 response regulator receiver YP_003068246.1 2643510 D 661410 CDS YP_003068247.1 254561152 8192646 complement(2643961..2644956) 1 NC_012988.1 type II fructose 1,6-bisphosphatae; in Escherichia coli this protein forms a dimer and binds manganese; fructose 1,6-bisphosphatase II 2644956 glpX 8192646 glpX Methylobacterium extorquens DM4 fructose 1,6-bisphosphatase II YP_003068247.1 2643961 R 661410 CDS YP_003068248.1 254561153 8195509 complement(2645192..2646514) 1 NC_012988.1 catalyzes the formation of L-aspartate 4-semialdehyde from L-homoserine; homoserine dehydrogenase 2646514 hom 8195509 hom Methylobacterium extorquens DM4 homoserine dehydrogenase YP_003068248.1 2645192 R 661410 CDS YP_003068249.1 254561154 8195571 2646881..2647180 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2647180 8195571 METDI2731 Methylobacterium extorquens DM4 hypothetical protein YP_003068249.1 2646881 D 661410 CDS YP_003068250.1 254561155 8192647 complement(2647220..2648206) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2648206 8192647 METDI2732 Methylobacterium extorquens DM4 hypothetical protein YP_003068250.1 2647220 R 661410 CDS YP_003068251.1 254561156 8192648 complement(2648311..2648649) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2648649 8192648 METDI2733 Methylobacterium extorquens DM4 hypothetical protein YP_003068251.1 2648311 R 661410 CDS YP_003068252.1 254561157 8192649 complement(2648725..2649975) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative sodium/proton nucleoside transporter 2649975 yeiM 8192649 yeiM Methylobacterium extorquens DM4 putative sodium/proton nucleoside transporter YP_003068252.1 2648725 R 661410 CDS YP_003068253.1 254561158 8196360 complement(2650065..2650727) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2650727 8196360 METDI2735 Methylobacterium extorquens DM4 hypothetical protein YP_003068253.1 2650065 R 661410 CDS YP_003068254.1 254561159 8192650 2651076..2651375 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2651375 8192650 METDI2736 Methylobacterium extorquens DM4 hypothetical protein YP_003068254.1 2651076 D 661410 CDS YP_003068255.1 254561160 8192651 complement(2651429..2652577) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11157937, 9387226; Product type pe : putative enzyme; putative glycosyl transferase 2652577 8192651 METDI2737 Methylobacterium extorquens DM4 putative glycosyl transferase YP_003068255.1 2651429 R 661410 CDS YP_003068256.1 254561161 8192652 2652661..2653863 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative DNA topoisomerase I 2653863 8192652 METDI2738 Methylobacterium extorquens DM4 putative DNA topoisomerase I YP_003068256.1 2652661 D 661410 CDS YP_003068257.1 254561162 8192653 complement(2653883..2654977) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2654977 8192653 METDI2739 Methylobacterium extorquens DM4 hypothetical protein YP_003068257.1 2653883 R 661410 CDS YP_003068258.1 254561163 8192654 2655124..2655306 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2655306 8192654 METDI2740 Methylobacterium extorquens DM4 hypothetical protein YP_003068258.1 2655124 D 661410 CDS YP_003068259.1 254561164 8192655 2655288..2656703 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative cytochrome bd-quinol oxidase subunit I 2656703 8192655 METDI2741 Methylobacterium extorquens DM4 putative cytochrome bd-quinol oxidase subunit I YP_003068259.1 2655288 D 661410 CDS YP_003068260.1 254561165 8192656 complement(2656795..2657502) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative Response regulator, CheY-like and LuxR domain 2657502 8192656 METDI2742 Methylobacterium extorquens DM4 putative Response regulator, CheY-like and LuxR domain YP_003068260.1 2656795 R 661410 CDS YP_003068261.1 254561166 8192657 complement(2657684..2658580) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2658580 8192657 METDI2743 Methylobacterium extorquens DM4 hypothetical protein YP_003068261.1 2657684 R 661410 CDS YP_003068262.1 254561167 8192658 complement(2658688..2659134) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2659134 8192658 METDI2744 Methylobacterium extorquens DM4 hypothetical protein YP_003068262.1 2658688 R 661410 CDS YP_003068263.1 254561168 8192659 complement(2659307..2659555) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2659555 8192659 METDI2745 Methylobacterium extorquens DM4 hypothetical protein YP_003068263.1 2659307 R 661410 CDS YP_003068264.1 254561169 8192660 2660009..2660839 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 8599111; Product type e : enzyme; Iron permease FTR1 2660839 ftr1 8192660 ftr1 Methylobacterium extorquens DM4 Iron permease FTR1 YP_003068264.1 2660009 D 661410 CDS YP_003068265.1 254561170 8195447 complement(2660952..2661425) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative phosphotyrosine protein phosphatase 2661425 8195447 METDI2747 Methylobacterium extorquens DM4 putative phosphotyrosine protein phosphatase YP_003068265.1 2660952 R 661410 CDS YP_003068266.1 254561171 8192661 complement(2661733..2662257) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2662257 8192661 METDI2748 Methylobacterium extorquens DM4 hypothetical protein YP_003068266.1 2661733 R 661410 CDS YP_003068267.1 254561172 8192662 complement(2662387..2663682) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; bifunctional HisD: L-histidinal:NAD+ dehydrogenase ; L-histidinol:NAD+ dehydrogenase 2663682 hisD 8192662 hisD Methylobacterium extorquens DM4 bifunctional HisD: L-histidinal:NAD+ dehydrogenase ; L-histidinol:NAD+ dehydrogenase YP_003068267.1 2662387 R 661410 CDS YP_003068268.1 254561173 8195560 complement(2663714..2664169) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2664169 8195560 METDI2750 Methylobacterium extorquens DM4 hypothetical protein YP_003068268.1 2663714 R 661410 CDS YP_003068269.1 254561174 8192663 2664463..2664843 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2664843 8192663 METDI2751 Methylobacterium extorquens DM4 hypothetical protein YP_003068269.1 2664463 D 661410 CDS YP_003068270.1 254561175 8192664 complement(2664939..2666228) 1 NC_012988.1 adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active; UDP-N-acetylglucosamine 1-carboxyvinyltransferase 2666228 murA 8192664 murA Methylobacterium extorquens DM4 UDP-N-acetylglucosamine 1-carboxyvinyltransferase YP_003068270.1 2664939 R 661410 CDS YP_003068271.1 254561176 8195736 complement(2666420..2666569) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2666569 8195736 METDI2753 Methylobacterium extorquens DM4 hypothetical protein YP_003068271.1 2666420 R 661410 CDS YP_003068272.1 254561177 8192665 2666819..2666992 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2666992 8192665 METDI2754 Methylobacterium extorquens DM4 hypothetical protein YP_003068272.1 2666819 D 661410 CDS YP_003068273.1 254561178 8192666 2667158..2668546 1 NC_012988.1 catalyzes the formation of 5-aminolevulinate from succinyl-CoA and glycine; 5-aminolevulinate synthase 2668546 hemA 8192666 hemA Methylobacterium extorquens DM4 5-aminolevulinate synthase YP_003068273.1 2667158 D 661410 CDS YP_003068274.1 254561179 8195547 2668586..2668792 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2668792 8195547 METDI2756 Methylobacterium extorquens DM4 hypothetical protein YP_003068274.1 2668586 D 661410 CDS YP_003068275.1 254561180 8192667 2668789..2669256 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2669256 8192667 METDI2757 Methylobacterium extorquens DM4 hypothetical protein YP_003068275.1 2668789 D 661410 CDS YP_003068276.1 254561181 8192668 complement(2669263..2669817) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2669817 8192668 METDI2758 Methylobacterium extorquens DM4 hypothetical protein YP_003068276.1 2669263 R 661410 CDS YP_003068277.1 254561182 8192669 2670039..2670344 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type t : transporter; Alkylphosphonate uptake protein 2670344 yjdM 8192669 yjdM Methylobacterium extorquens DM4 Alkylphosphonate uptake protein YP_003068277.1 2670039 D 661410 CDS YP_003068278.1 254561183 8196370 complement(2670367..2671098) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; Beta-lactamase-like 2671098 8196370 METDI2760 Methylobacterium extorquens DM4 Beta-lactamase-like YP_003068278.1 2670367 R 661410 CDS YP_003068279.1 254561184 8192670 2671483..2672649 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2672649 8192670 METDI2761 Methylobacterium extorquens DM4 hypothetical protein YP_003068279.1 2671483 D 661410 CDS YP_003068280.1 254561185 8192671 2672787..2674169 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 8760910; Product type e : enzyme; 2-dehydro-3-deoxyphosphoheptonate aldolase 2674169 aroG2 8192671 aroG2 Methylobacterium extorquens DM4 2-dehydro-3-deoxyphosphoheptonate aldolase YP_003068280.1 2672787 D 661410 CDS YP_003068281.1 254561186 8195094 2674390..2674605 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2674605 8195094 METDI2763 Methylobacterium extorquens DM4 hypothetical protein YP_003068281.1 2674390 D 661410 CDS YP_003068282.1 254561187 8192672 complement(2674683..2675228) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2675228 8192672 METDI2764 Methylobacterium extorquens DM4 hypothetical protein YP_003068282.1 2674683 R 661410 CDS YP_003068283.1 254561188 8192673 2675560..2676474 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2676474 8192673 METDI2765 Methylobacterium extorquens DM4 hypothetical protein YP_003068283.1 2675560 D 661410 CDS YP_003068284.1 254561189 8192674 2676509..2677180 1 NC_012988.1 Essential for recycling GMP and indirectly, cGMP; guanylate kinase 2677180 gmk 8192674 gmk Methylobacterium extorquens DM4 guanylate kinase YP_003068284.1 2676509 D 661410 CDS YP_003068285.1 254561190 8195523 complement(2677227..2678975) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative ABC transporter, fused ATPase and transmembrane permease domains 2678975 8195523 METDI2767 Methylobacterium extorquens DM4 putative ABC transporter, fused ATPase and transmembrane permease domains YP_003068285.1 2677227 R 661410 CDS YP_003068286.1 254561191 8192675 complement(2679148..2679663) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2679663 8192675 METDI2768 Methylobacterium extorquens DM4 hypothetical protein YP_003068286.1 2679148 R 661410 CDS YP_003068287.1 254561192 8192676 complement(2679852..2680517) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative cob(II)yrinic acid a,c-diamide reductase 2680517 8192676 METDI2769 Methylobacterium extorquens DM4 putative cob(II)yrinic acid a,c-diamide reductase YP_003068287.1 2679852 R 661410 CDS YP_003068288.1 254561193 8192677 complement(2680774..2680881) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2680881 8192677 METDI2770 Methylobacterium extorquens DM4 hypothetical protein YP_003068288.1 2680774 R 661410 CDS YP_003068289.1 254561194 8192678 2681031..2681426 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2681426 8192678 METDI2771 Methylobacterium extorquens DM4 hypothetical protein YP_003068289.1 2681031 D 661410 CDS YP_003068290.1 254561195 8192679 complement(2681464..2683644) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type prc : putative receptor; putative Catecholate siderophore receptor fiu precursor (TonB-dependent receptor fiu) 2683644 8192679 METDI2772 Methylobacterium extorquens DM4 putative Catecholate siderophore receptor fiu precursor (TonB-dependent receptor fiu) YP_003068290.1 2681464 R 661410 CDS YP_003068291.1 254561196 8192680 complement(2684144..2684764) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 4560498, 7016177; Product type e : enzyme; multifunctional: 2-keto-3-deoxygluconate 6-phosphate aldolase; 2-keto-4-hydroxyglutarate aldolase; oxaloacetate decarboxylase 2684764 eda 8192680 eda Methylobacterium extorquens DM4 multifunctional: 2-keto-3-deoxygluconate 6-phosphate aldolase; 2-keto-4-hydroxyglutarate aldolase; oxaloacetate decarboxylase YP_003068291.1 2684144 R 661410 CDS YP_003068292.1 254561197 8195325 complement(2684984..2686813) 1 NC_012988.1 catalyzes the formation of 2-dehydro-3-deoxy-6-phospho-D-gluconate from 6-phospho-D-gluconate; phosphogluconate dehydratase 2686813 edd 8195325 edd Methylobacterium extorquens DM4 phosphogluconate dehydratase YP_003068292.1 2684984 R 661410 CDS YP_003068293.1 254561198 8195326 complement(2687163..2688170) 1 NC_012988.1 becomes active under oxidative stress; four conserved cysteines bind a zinc atom when they are in the reduced state and the enzyme is inactive; oxidative stress results in oxidized cysteines, release of zinc, and binding of Hsp33 to aggregation-prone proteins; forms dimers and higher order oligomers; Hsp33-like chaperonin 2688170 hslO 8195326 hslO Methylobacterium extorquens DM4 Hsp33-like chaperonin YP_003068293.1 2687163 R 661410 CDS YP_003068294.1 254561199 8192681 complement(2688430..2690541) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative outer membrane porin (OMPA-like) 2690541 8192681 METDI2776 Methylobacterium extorquens DM4 putative outer membrane porin (OMPA-like) YP_003068294.1 2688430 R 661410 CDS YP_003068295.1 254561200 8192682 complement(2690898..2691410) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2691410 8192682 METDI2777 Methylobacterium extorquens DM4 hypothetical protein YP_003068295.1 2690898 R 661410 CDS YP_003068296.1 254561201 8192683 2691788..2692210 1 NC_012988.1 catalyzes the formation of nucleoside triphosphate from ATP and nucleoside diphosphate; nucleoside diphosphate kinase 2692210 ndk 8192683 ndk Methylobacterium extorquens DM4 nucleoside diphosphate kinase YP_003068296.1 2691788 D 661410 CDS YP_003068297.1 254561202 8195774 2692495..2692875 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2692875 8195774 METDI2779 Methylobacterium extorquens DM4 hypothetical protein YP_003068297.1 2692495 D 661410 CDS YP_003068298.1 254561203 8192684 complement(2692972..2694108) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative metallopeptidase 2694108 8192684 METDI2780 Methylobacterium extorquens DM4 putative metallopeptidase YP_003068298.1 2692972 R 661410 CDS YP_003068299.1 254561204 8192685 complement(2694116..2695405) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2695405 8192685 METDI2781 Methylobacterium extorquens DM4 hypothetical protein YP_003068299.1 2694116 R 661410 CDS YP_003068300.1 254561205 8192686 complement(2695794..2696006) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2696006 8192686 METDI2782 Methylobacterium extorquens DM4 hypothetical protein YP_003068300.1 2695794 R 661410 CDS YP_003068301.1 254561206 8192687 complement(2696035..2698092) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 1848300; Product type m : membrane component; carbon starvation protein A precursor 2698092 cstA 8192687 cstA Methylobacterium extorquens DM4 carbon starvation protein A precursor YP_003068301.1 2696035 R 661410 CDS YP_003068302.1 254561207 8195226 complement(2698393..2699076) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2699076 8195226 METDI2784 Methylobacterium extorquens DM4 hypothetical protein YP_003068302.1 2698393 R 661410 CDS YP_003068303.1 254561208 8192688 complement(2699009..2699794) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2699794 8192688 METDI2785 Methylobacterium extorquens DM4 hypothetical protein YP_003068303.1 2699009 R 661410 CDS YP_003068304.1 254561209 8192689 complement(2699814..2700449) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2700449 8192689 METDI2786 Methylobacterium extorquens DM4 hypothetical protein YP_003068304.1 2699814 R 661410 CDS YP_003068305.1 254561210 8192690 2700695..2701009 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2701009 8192690 METDI2788 Methylobacterium extorquens DM4 hypothetical protein YP_003068305.1 2700695 D 661410 CDS YP_003068306.1 254561211 8192691 2701109..2703250 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative Histidine protein kinase of the HWE family 2703250 8192691 METDI2789 Methylobacterium extorquens DM4 putative Histidine protein kinase of the HWE family YP_003068306.1 2701109 D 661410 CDS YP_003068307.1 254561212 8192692 complement(2703273..2704109) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 10427017, 11934293, 99357626; Product type e : enzyme; 2,5-diketo-D-gluconate reductase A 2704109 dkgA 8192692 dkgA Methylobacterium extorquens DM4 2,5-diketo-D-gluconate reductase A YP_003068307.1 2703273 R 661410 CDS YP_003068308.1 254561213 8195297 complement(2704224..2705003) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 1522059, 1551834; Product type pr : putative regulator; putative Regulatory protein, Crp family 2705003 8195297 METDI2791 Methylobacterium extorquens DM4 putative Regulatory protein, Crp family YP_003068308.1 2704224 R 661410 CDS YP_003068309.1 254561214 8192693 complement(2705304..2706836) 1 NC_012988.1 catalyzes the formation of alpha-1,4-glucan chains from ADP-glucose; glycogen synthase 2706836 glgA 8192693 glgA Methylobacterium extorquens DM4 glycogen synthase YP_003068309.1 2705304 R 661410 CDS YP_003068310.1 254561215 8195488 complement(2707096..2708721) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative glycosyl hydrolase 2708721 8195488 METDI2793 Methylobacterium extorquens DM4 putative glycosyl hydrolase YP_003068310.1 2707096 R 661410 CDS YP_003068311.1 254561216 8192694 2709050..2711584 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; glycogen phosphorylase 2711584 glgP 8192694 glgP Methylobacterium extorquens DM4 glycogen phosphorylase YP_003068311.1 2709050 D 661410 CDS YP_003068312.1 254561217 8195490 complement(2711762..2712703) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2712703 8195490 METDI2795 Methylobacterium extorquens DM4 hypothetical protein YP_003068312.1 2711762 R 661410 CDS YP_003068313.1 254561218 8192695 complement(2712747..2713175) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2713175 8192695 METDI2796 Methylobacterium extorquens DM4 hypothetical protein YP_003068313.1 2712747 R 661410 CDS YP_003068314.1 254561219 8192696 complement(2713296..2716226) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type rc : receptor; diguanylate cyclase (GGDEF domain) /phosphodiesterase (EAL domain) with PAS/PAC and GAF sensor domains 2716226 8192696 METDI2797 Methylobacterium extorquens DM4 diguanylate cyclase (GGDEF domain) /phosphodiesterase (EAL domain) with PAS/PAC and GAF sensor domains YP_003068314.1 2713296 R 661410 CDS YP_003068315.1 254561220 8192697 2716656..2717675 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11024259, 7537247, 8051012; Product type pe : putative enzyme; putative glycosyl transferase 2717675 8192697 METDI2798 Methylobacterium extorquens DM4 putative glycosyl transferase YP_003068315.1 2716656 D 661410 CDS YP_003068316.1 254561221 8192698 2717687..2718610 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative UDP-glucose 4-epimerase 2718610 8192698 METDI2799 Methylobacterium extorquens DM4 putative UDP-glucose 4-epimerase YP_003068316.1 2717687 D 661410 CDS YP_003068317.1 254561222 8192699 complement(2718615..2719226) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 11583992, 16511052; Product type e : enzyme; FMN-dependent NADH-azoreductase (FMN-dependent NADH-azo compound oxidoreductase) (Azo-dye reductase) 2719226 azoR 8192699 azoR Methylobacterium extorquens DM4 FMN-dependent NADH-azoreductase (FMN-dependent NADH-azo compound oxidoreductase) (Azo-dye reductase) YP_003068317.1 2718615 R 661410 CDS YP_003068318.1 254561223 8195123 2719303..2719707 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11443074, 9573147; Product type pr : putative regulator; putative transcriptional regulator, HxlR family 2719707 8195123 METDI2801 Methylobacterium extorquens DM4 putative transcriptional regulator, HxlR family YP_003068318.1 2719303 D 661410 CDS YP_003068319.1 254561224 8192700 complement(2719727..2721700) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative nucleotide sugar epimerase/dehydratase 2721700 8192700 METDI2802 Methylobacterium extorquens DM4 putative nucleotide sugar epimerase/dehydratase YP_003068319.1 2719727 R 661410 CDS YP_003068320.1 254561225 8192701 complement(2721804..2722655) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2722655 8192701 METDI2803 Methylobacterium extorquens DM4 hypothetical protein YP_003068320.1 2721804 R 661410 CDS YP_003068321.1 254561226 8192702 complement(2722662..2723003) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2723003 8192702 METDI2804 Methylobacterium extorquens DM4 hypothetical protein YP_003068321.1 2722662 R 661410 CDS YP_003068322.1 254561227 8192703 complement(2723029..2723595) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2723595 8192703 METDI2805 Methylobacterium extorquens DM4 hypothetical protein YP_003068322.1 2723029 R 661410 CDS YP_003068323.1 254561228 8192704 complement(2723667..2724227) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2724227 8192704 METDI2806 Methylobacterium extorquens DM4 hypothetical protein YP_003068323.1 2723667 R 661410 CDS YP_003068324.1 254561229 8192705 complement(2724315..2725763) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 8841401; Product type e : enzyme; homospermidine synthase 2725763 hss 8192705 hss Methylobacterium extorquens DM4 homospermidine synthase YP_003068324.1 2724315 R 661410 CDS YP_003068325.1 254561230 8195580 2726037..2726225 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 2726225 8195580 METDI2808 Methylobacterium extorquens DM4 hypothetical protein YP_003068325.1 2726037 D 661410 CDS YP_003068326.1 254561231 8192706 complement(2726385..2726942) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative acyltransferase with acyl-CoA N-acyltransferase domain 2726942 8192706 METDI2809 Methylobacterium extorquens DM4 putative acyltransferase with acyl-CoA N-acyltransferase domain YP_003068326.1 2726385 R 661410 CDS YP_003068327.1 254561232 8192707 complement(2727121..2728287) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11073919; Product type pe : putative enzyme; putative ornithine/diaminopimelate PLP-dependent decarboxylase 2728287 8192707 METDI2810 Methylobacterium extorquens DM4 putative ornithine/diaminopimelate PLP-dependent decarboxylase YP_003068327.1 2727121 R 661410 CDS YP_003068328.1 254561233 8192708 2728972..2730591 1 NC_012988.1 involved in the biosynthesis of osmoregulated periplasmic glucans; required for the assembly of the polyglucose structure of glucan; glucan biosynthesis protein G 2730591 mdoG 8192708 mdoG Methylobacterium extorquens DM4 glucan biosynthesis protein G YP_003068328.1 2728972 D 661410 CDS YP_003068329.1 254561234 8195676 2730564..2731100 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2731100 8195676 METDI2812 Methylobacterium extorquens DM4 hypothetical protein YP_003068329.1 2730564 D 661410 CDS YP_003068330.1 254561235 8192709 2731244..2732332 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 97165929; Product type e : enzyme; NADH:flavin oxidoreductase/NADH oxidase; putative FMN-linked N-ethylmaleimide reductase 2732332 8192709 METDI2813 Methylobacterium extorquens DM4 NADH:flavin oxidoreductase/NADH oxidase; putative FMN-linked N-ethylmaleimide reductase YP_003068330.1 2731244 D 661410 CDS YP_003068331.1 254561236 8192710 2732414..2733127 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative haloacid dehalogenase family hydrolase 2733127 8192710 METDI2814 Methylobacterium extorquens DM4 putative haloacid dehalogenase family hydrolase YP_003068331.1 2732414 D 661410 CDS YP_003068332.1 254561237 8192711 complement(2733121..2733618) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2733618 8192711 METDI2815 Methylobacterium extorquens DM4 hypothetical protein YP_003068332.1 2733121 R 661410 CDS YP_003068333.1 254561238 8192712 2733776..2734342 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2734342 8192712 METDI2816 Methylobacterium extorquens DM4 hypothetical protein YP_003068333.1 2733776 D 661410 CDS YP_003068334.1 254561239 8192713 2734339..2734857 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2734857 8192713 METDI2817 Methylobacterium extorquens DM4 hypothetical protein YP_003068334.1 2734339 D 661410 CDS YP_003068335.1 254561240 8192714 2735022..2736080 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; Fatty acid/phospholipid synthesis protein 2736080 plsX 8192714 plsX Methylobacterium extorquens DM4 Fatty acid/phospholipid synthesis protein YP_003068335.1 2735022 D 661410 CDS YP_003068336.1 254561241 8195867 2736114..2737094 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 10593943, 11078736, 11243824, 8631920; Product type e : enzyme; 3-oxoacyl-[acyl-carrier-protein] synthase III; acetylCoA ACP transacylase 2737094 fabH 8195867 fabH Methylobacterium extorquens DM4 3-oxoacyl-[acyl-carrier-protein] synthase III; acetylCoA ACP transacylase YP_003068336.1 2736114 D 661410 CDS YP_003068337.1 254561242 8195346 2737303..2737629 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 2991205, 3528129, 6397321, 8980235, 91348524, 92021785, 92155171; Product type f : factor; integration host factor (IHF), DNA-binding protein, alpha subunit 2737629 ihfA 8195346 ihfA Methylobacterium extorquens DM4 integration host factor (IHF), DNA-binding protein, alpha subunit YP_003068337.1 2737303 D 661410 CDS YP_003068338.1 254561243 8195589 2737683..2738180 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcriptional regulator, MerR family 2738180 8195589 METDI2821 Methylobacterium extorquens DM4 putative transcriptional regulator, MerR family YP_003068338.1 2737683 D 661410 CDS YP_003068339.1 254561244 8192715 2738344..2738742 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2738742 8192715 METDI2823 Methylobacterium extorquens DM4 hypothetical protein YP_003068339.1 2738344 D 661410 CDS YP_003068340.1 254561245 8192716 2738884..2739357 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2739357 8192716 METDI2824 Methylobacterium extorquens DM4 hypothetical protein YP_003068340.1 2738884 D 661410 CDS YP_003068341.1 254561246 8192717 2739617..2741569 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2741569 8192717 METDI2825 Methylobacterium extorquens DM4 hypothetical protein YP_003068341.1 2739617 D 661410 CDS YP_003068342.1 254561247 8192718 2741673..2742977 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2742977 8192718 METDI2826 Methylobacterium extorquens DM4 hypothetical protein YP_003068342.1 2741673 D 661410 CDS YP_003068343.1 254561248 8192719 2743025..2744596 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; SpoVR family protein 2744596 8192719 METDI2827 Methylobacterium extorquens DM4 SpoVR family protein YP_003068343.1 2743025 D 661410 CDS YP_003068344.1 254561249 8192720 complement(2744774..2745433) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 10606510, 3301838; Product type e : enzyme; phosphoribosylglycinamide formyltransferase 1 2745433 purN 8192720 purN Methylobacterium extorquens DM4 phosphoribosylglycinamide formyltransferase 1 YP_003068344.1 2744774 R 661410 CDS YP_003068345.1 254561250 8195939 complement(2745430..2746497) 1 NC_012988.1 catalyzes the formation of 1-(5-phosphoribosyl)-5-aminoimidazole from 2-(formamido)-N1-(5-phosphoribosyl)acetamidine and ATP in purine biosynthesis; phosphoribosylaminoimidazole synthetase 2746497 purM 8195939 purM Methylobacterium extorquens DM4 phosphoribosylaminoimidazole synthetase YP_003068345.1 2745430 R 661410 CDS YP_003068346.1 254561251 8195938 complement(2746494..2746655) 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 2746655 8195938 METDI2830 Methylobacterium extorquens DM4 hypothetical protein YP_003068346.1 2746494 R 661410 CDS YP_003068347.1 254561252 8192721 2746801..2747913 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative permease (PerM family) 2747913 8192721 METDI2831 Methylobacterium extorquens DM4 putative permease (PerM family) YP_003068347.1 2746801 D 661410 CDS YP_003068348.1 254561253 8192722 2748035..2748793 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2748793 8192722 METDI2832 Methylobacterium extorquens DM4 hypothetical protein YP_003068348.1 2748035 D 661410 CDS YP_003068349.1 254561254 8192723 2748933..2751299 1 NC_012988.1 catalyzes the reversible transfer of the terminal phosphate of ATP to form a long chain polyphosphate; polyphosphate kinase 2751299 ppk 8192723 ppk Methylobacterium extorquens DM4 polyphosphate kinase YP_003068349.1 2748933 D 661410 CDS YP_003068350.1 254561255 8195884 2751488..2753041 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; exopolyphosphatase 2753041 8195884 METDI2834 Methylobacterium extorquens DM4 exopolyphosphatase YP_003068350.1 2751488 D 661410 CDS YP_003068351.1 254561256 8192724 complement(2753120..2753419) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2753419 8192724 METDI2835 Methylobacterium extorquens DM4 hypothetical protein YP_003068351.1 2753120 R 661410 CDS YP_003068352.1 254561257 8192725 complement(2753949..2755151) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 8096210; Product type e : enzyme; aspartate aminotransferase A 2755151 aatA 8192725 aatA Methylobacterium extorquens DM4 aspartate aminotransferase A YP_003068352.1 2753949 R 661410 CDS YP_003068353.1 254561258 8195043 2755592..2757574 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative Acyl CoA:acetate/3-ketoacid CoA transferase; fused alpha subunit and beta subunit 2757574 8195043 METDI2837 Methylobacterium extorquens DM4 putative Acyl CoA:acetate/3-ketoacid CoA transferase; fused alpha subunit and beta subunit YP_003068353.1 2755592 D 661410 CDS YP_003068354.1 254561259 8192726 2757951..2759621 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type prc : putative receptor; putative methyl-accepting chemotaxis sensory transducer precursor 2759621 8192726 METDI2838 Methylobacterium extorquens DM4 putative methyl-accepting chemotaxis sensory transducer precursor YP_003068354.1 2757951 D 661410 CDS YP_003068355.1 254561260 8192727 2759877..2760926 1 NC_012988.1 one of the last subunits in the assembly of the 30S subunit; absence of S2 does not inhibit assembly but results in an inactive subunit; 30S ribosomal protein S2 2760926 rpsB 8192727 rpsB Methylobacterium extorquens DM4 30S ribosomal protein S2 YP_003068355.1 2759877 D 661410 CDS YP_003068356.1 254561261 8196053 2761071..2761991 1 NC_012988.1 EF-Ts; functions during elongation stage of protein translation; forms a dimer; associates with EF-Tu-GDP complex and promotes exchange of GDP to GTP resulting in regeneration of the active form of EF-Tu; elongation factor Ts 2761991 tsf 8196053 tsf Methylobacterium extorquens DM4 elongation factor Ts YP_003068356.1 2761071 D 661410 CDS YP_003068357.1 254561262 8196286 2762158..2762880 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 15857829; Product type e : enzyme; uridylate kinase 2762880 pyrH 8196286 pyrH Methylobacterium extorquens DM4 uridylate kinase YP_003068357.1 2762158 D 661410 CDS YP_003068358.1 254561263 8195953 complement(2762992..2763531) 1 NC_012988.1 catalyzes the hydrolysis of pyrophosphate to phosphate; inorganic pyrophosphatase 2763531 ppa 8195953 ppa Methylobacterium extorquens DM4 inorganic pyrophosphatase YP_003068358.1 2762992 R 661410 CDS YP_003068359.1 254561264 8195880 complement(2763806..2764312) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative GCN5-related N-acetyltransferase 2764312 8195880 METDI2843 Methylobacterium extorquens DM4 putative GCN5-related N-acetyltransferase YP_003068359.1 2763806 R 661410 CDS YP_003068360.1 254561265 8192728 2764450..2765175 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2765175 8192728 METDI2844 Methylobacterium extorquens DM4 hypothetical protein YP_003068360.1 2764450 D 661410 CDS YP_003068361.1 254561266 8192729 2765184..2766179 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2766179 8192729 METDI2845 Methylobacterium extorquens DM4 hypothetical protein YP_003068361.1 2765184 D 661410 CDS YP_003068362.1 254561267 8192730 complement(2766241..2767296) 1 NC_012988.1 adds the O-linked and N-linked 3(R)-hydroxy fatty acids to the glucosamine disaccharide during lipid A biosynthesis; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase 2767296 lpxD 8192730 lpxD Methylobacterium extorquens DM4 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase YP_003068362.1 2766241 R 661410 CDS YP_003068363.1 254561268 8195649 complement(2767459..2770023) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor; putative outer membrane protein assembly factor 2770023 8195649 METDI2847 Methylobacterium extorquens DM4 putative outer membrane protein assembly factor YP_003068363.1 2767459 R 661410 CDS YP_003068364.1 254561269 8192731 complement(2770384..2771544) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 15686556; Product type e : enzyme; membrane-associated zinc metalloprotease 2771544 8192731 METDI2848 Methylobacterium extorquens DM4 membrane-associated zinc metalloprotease YP_003068364.1 2770384 R 661410 CDS YP_003068365.1 254561270 8192732 complement(2771761..2772939) 1 NC_012988.1 catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate; 1-deoxy-D-xylulose 5-phosphate reductoisomerase 2772939 dxr 8192732 dxr Methylobacterium extorquens DM4 1-deoxy-D-xylulose 5-phosphate reductoisomerase YP_003068365.1 2771761 R 661410 CDS YP_003068366.1 254561271 8195320 complement(2772954..2773814) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 2995359, 30751; Product type e : enzyme; CDP-diglyceride synthase 2773814 cdsA 8195320 cdsA Methylobacterium extorquens DM4 CDP-diglyceride synthase YP_003068366.1 2772954 R 661410 CDS YP_003068367.1 254561272 8195160 complement(2773814..2774593) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 11287651, 9882662; Product type e : enzyme; undecaprenyl pyrophosphate synthetase (di-trans, poly-cis-decaprenylcistransferase) 2774593 uppS 8195160 uppS Methylobacterium extorquens DM4 undecaprenyl pyrophosphate synthetase (di-trans, poly-cis-decaprenylcistransferase) YP_003068367.1 2773814 R 661410 CDS YP_003068368.1 254561273 8196306 complement(2774664..2775227) 1 NC_012988.1 Rrf; Frr; ribosome-recycling factor; release factor 4; RF4; recycles ribosomes upon translation termination along with release factor RF-3 and elongation factor EF-G; A GTPase-dependent process results in release of 50S from 70S; inhibited by release factor RF-1; essential for viability; structurally similar to tRNAs; ribosome recycling factor 2775227 frr 8196306 frr Methylobacterium extorquens DM4 ribosome recycling factor YP_003068368.1 2774664 R 661410 CDS YP_003068369.1 254561274 8195444 2775560..2776699 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2776699 8195444 METDI2853 Methylobacterium extorquens DM4 hypothetical protein YP_003068369.1 2775560 D 661410 CDS YP_003068370.1 254561275 8192733 complement(2777022..2778302) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative ubiquinone biosynthesis hydroxylase/monooxygenase 2778302 8192733 METDI2854 Methylobacterium extorquens DM4 putative ubiquinone biosynthesis hydroxylase/monooxygenase YP_003068370.1 2777022 R 661410 CDS YP_003068371.1 254561276 8192734 2778435..2778608 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2778608 8192734 METDI2855 Methylobacterium extorquens DM4 hypothetical protein YP_003068371.1 2778435 D 661410 CDS YP_003068372.1 254561277 8192735 2778695..2779639 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 1200544, 12878731, 13129938, 8113168, 9689094; Product type r : regulator; transcriptional regulator, LysR family 2779639 8192735 METDI2856 Methylobacterium extorquens DM4 transcriptional regulator, LysR family YP_003068372.1 2778695 D 661410 CDS YP_003068373.1 254561278 8192736 2779884..2780633 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative 3-oxoacyl-[acyl-carrier-protein] reductase (fabG-like) 2780633 8192736 METDI2857 Methylobacterium extorquens DM4 putative 3-oxoacyl-[acyl-carrier-protein] reductase (fabG-like) YP_003068373.1 2779884 D 661410 CDS YP_003068374.1 254561279 8192737 2780651..2781511 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative transketolase, alpha subunit 2781511 8192737 METDI2858 Methylobacterium extorquens DM4 putative transketolase, alpha subunit YP_003068374.1 2780651 D 661410 CDS YP_003068375.1 254561280 8192738 2781508..2782527 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative transketolase (C-terminal domain) 2782527 8192738 METDI2859 Methylobacterium extorquens DM4 putative transketolase (C-terminal domain) YP_003068375.1 2781508 D 661410 CDS YP_003068376.1 254561281 8192739 2782690..2783706 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 1809844; Product type prc : putative receptor; putative ABC transporter substrate-binding protein, putative C4-dicarboxylate-binding periplasmic protein DctP precursor 2783706 8192739 METDI2860 Methylobacterium extorquens DM4 putative ABC transporter substrate-binding protein, putative C4-dicarboxylate-binding periplasmic protein DctP precursor YP_003068376.1 2782690 D 661410 CDS YP_003068377.1 254561282 8192740 2783718..2785604 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative ABC transporter permease protein 2785604 8192740 METDI2861 Methylobacterium extorquens DM4 putative ABC transporter permease protein YP_003068377.1 2783718 D 661410 CDS YP_003068378.1 254561283 8192741 complement(2785686..2785862) 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 2785862 8192741 METDI2862 Methylobacterium extorquens DM4 hypothetical protein YP_003068378.1 2785686 R 661410 CDS YP_003068379.1 254561284 8192742 complement(2785994..2786248) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2786248 8192742 METDI2863 Methylobacterium extorquens DM4 hypothetical protein YP_003068379.1 2785994 R 661410 CDS YP_003068380.1 254561285 8192743 2786474..2787199 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10433972; Product type pe : putative enzyme; putative CoxB-related 2787199 8192743 METDI2864 Methylobacterium extorquens DM4 putative CoxB-related YP_003068380.1 2786474 D 661410 CDS YP_003068381.1 254561286 8192744 complement(2787429..2795819) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16113259; hypothetical protein 2795819 8192744 METDI2865 Methylobacterium extorquens DM4 hypothetical protein YP_003068381.1 2787429 R 661410 CDS YP_003068382.1 254561287 8192745 2796215..2797078 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 10876240; Product type e : enzyme; acyl-CoA thioesterase II 2797078 tesB 8192745 tesB Methylobacterium extorquens DM4 acyl-CoA thioesterase II YP_003068382.1 2796215 D 661410 CDS YP_003068383.1 254561288 8196183 2797341..2797679 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 11847102, 7590157, 7904973, 8843440, 9720863, 9733647, 99248410; Product type r : regulator; nitrogen assimilation regulatory protein for GlnL, GlnE, and AmtB 2797679 glnK 8196183 glnK Methylobacterium extorquens DM4 nitrogen assimilation regulatory protein for GlnL, GlnE, and AmtB YP_003068383.1 2797341 D 661410 CDS YP_003068384.1 254561289 8195504 2797812..2799308 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type t : transporter; ammonium transport protein (Amt family) 2799308 amtB 8195504 amtB Methylobacterium extorquens DM4 ammonium transport protein (Amt family) YP_003068384.1 2797812 D 661410 CDS YP_003068385.1 254561290 8195075 2799650..2800912 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2800912 8195075 METDI2869 Methylobacterium extorquens DM4 hypothetical protein YP_003068385.1 2799650 D 661410 CDS YP_003068386.1 254561291 8192746 2801094..2803709 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type cp : cell process; DNA-binding membrane protein required for chromosome resolution and partitioning 2803709 ftsK 8192746 ftsK Methylobacterium extorquens DM4 DNA-binding membrane protein required for chromosome resolution and partitioning YP_003068386.1 2801094 D 661410 CDS YP_003068387.1 254561292 8195453 2803861..2806020 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type prc : putative receptor; putative TonB-dependent receptor/siderophore receptor protein 2806020 8195453 METDI2871 Methylobacterium extorquens DM4 putative TonB-dependent receptor/siderophore receptor protein YP_003068387.1 2803861 D 661410 CDS YP_003068388.1 254561293 8192747 2806376..2808343 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative histidine kinase of the HWE family 2808343 8192747 METDI2872 Methylobacterium extorquens DM4 putative histidine kinase of the HWE family YP_003068388.1 2806376 D 661410 CDS YP_003068389.1 254561294 8192748 complement(2808366..2808668) 1 NC_012988.1 Evidence 1c : Function experimentally demonstrated in the studied genus; PubMedId : 17921299; Product type e : enzyme; Formate dehydrogenase subunit B 2808668 fdh4B 8192748 fdh4B Methylobacterium extorquens DM4 Formate dehydrogenase subunit B YP_003068389.1 2808366 R 661410 CDS YP_003068390.1 254561295 8195370 complement(2808665..2810980) 1 NC_012988.1 Evidence 1c : Function experimentally demonstrated in the studied genus; PubMedId : 17921299; Product type e : enzyme; Formate dehydrogenase subunit A 2810980 fdh4A 8195370 fdh4A Methylobacterium extorquens DM4 Formate dehydrogenase subunit A YP_003068390.1 2808665 R 661410 CDS YP_003068391.1 254561296 8195369 complement(2811502..2812578) 1 NC_012988.1 catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway; uses a flavin nucleotide as an essential cofactor; class 2 enzymes are monomeric and compared to the class 1 class 2 possess an extended N terminus, which plays a role in the membrane association of the enzyme and provides the binding site for the respiratory quinones that serve as physiological electron acceptors; dihydroorotate dehydrogenase 2 2812578 pyrD 8195369 pyrD Methylobacterium extorquens DM4 dihydroorotate dehydrogenase 2 YP_003068391.1 2811502 R 661410 CDS YP_003068392.1 254561297 8195949 complement(2812575..2812925) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2812925 8195949 METDI2876 Methylobacterium extorquens DM4 hypothetical protein YP_003068392.1 2812575 R 661410 CDS YP_003068393.1 254561298 8192749 2813148..2813780 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative LexA/Signal peptidase 2813780 8192749 METDI2877 Methylobacterium extorquens DM4 putative LexA/Signal peptidase YP_003068393.1 2813148 D 661410 CDS YP_003068394.1 254561299 8192750 complement(2813791..2814120) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 2814120 8192750 METDI2878 Methylobacterium extorquens DM4 hypothetical protein YP_003068394.1 2813791 R 661410 CDS YP_003068395.1 254561300 8192751 complement(2814291..2814599) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2814599 8192751 METDI2879 Methylobacterium extorquens DM4 hypothetical protein YP_003068395.1 2814291 R 661410 CDS YP_003068396.1 254561301 8192752 complement(2814642..2815502) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 10617639, 3309158, 9622597; Product type e : enzyme; serine acetyltransferase 2815502 cysE-1 8192752 cysE-1 Methylobacterium extorquens DM4 serine acetyltransferase YP_003068396.1 2814642 R 661410 CDS YP_003068397.1 254561302 8195251 complement(2815783..2816682) 1 NC_012988.1 consists of N-terminal helix-turn-helix domain and C-terminal shikimate kinase-like domain which may bind benzoyl-CoA; controls inducible expression of the bzd catabolic operon that is involved in the anaerobic catabolism of benzoate; anaerobic benzoate catabolism transcriptional regulator 2816682 8195251 METDI2881 Methylobacterium extorquens DM4 anaerobic benzoate catabolism transcriptional regulator YP_003068397.1 2815783 R 661410 CDS YP_003068398.1 254561303 8192753 complement(2817145..2817297) 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 2817297 8192753 METDI2882 Methylobacterium extorquens DM4 hypothetical protein YP_003068398.1 2817145 R 661410 CDS YP_003068399.1 254561304 8192754 complement(2817346..2819619) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type r : regulator; integral membrane sensor signal transduction histidine kinase 2819619 8192754 METDI2883 Methylobacterium extorquens DM4 integral membrane sensor signal transduction histidine kinase YP_003068399.1 2817346 R 661410 CDS YP_003068400.1 254561305 8192755 complement(2819741..2819944) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2819944 8192755 METDI2884 Methylobacterium extorquens DM4 hypothetical protein YP_003068400.1 2819741 R 661410 CDS YP_003068401.1 254561306 8192756 complement(2819956..2820222) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2820222 8192756 METDI2885 Methylobacterium extorquens DM4 hypothetical protein YP_003068401.1 2819956 R 661410 CDS YP_003068402.1 254561307 8192757 complement(2820396..2821130) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type r : regulator; response regulator in two-component regulatory system (OmpR family) 2821130 ompR 8192757 ompR Methylobacterium extorquens DM4 response regulator in two-component regulatory system (OmpR family) YP_003068402.1 2820396 R 661410 CDS YP_003068403.1 254561308 8195806 2821476..2823326 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative two-component system regulator: response regulator receiver (N-terminal) and histidine kinase (C-terminal) 2823326 8195806 METDI2887 Methylobacterium extorquens DM4 putative two-component system regulator: response regulator receiver (N-terminal) and histidine kinase (C-terminal) YP_003068403.1 2821476 D 661410 CDS YP_003068404.1 254561309 8192758 complement(2823412..2823810) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative glyoxalase/Bleomycin resistance protein/dioxygenase 2823810 8192758 METDI2888 Methylobacterium extorquens DM4 putative glyoxalase/Bleomycin resistance protein/dioxygenase YP_003068404.1 2823412 R 661410 CDS YP_003068405.1 254561310 8192759 complement(2823949..2824221) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2824221 8192759 METDI2889 Methylobacterium extorquens DM4 hypothetical protein YP_003068405.1 2823949 R 661410 CDS YP_003068406.1 254561311 8192760 complement(2824319..2825011) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcriptional regulator with N-terminal cNMP-binding domain 2825011 8192760 METDI2890 Methylobacterium extorquens DM4 putative transcriptional regulator with N-terminal cNMP-binding domain YP_003068406.1 2824319 R 661410 CDS YP_003068407.1 254561312 8192761 complement(2825234..2826415) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2826415 8192761 METDI2891 Methylobacterium extorquens DM4 hypothetical protein YP_003068407.1 2825234 R 661410 CDS YP_003068408.1 254561313 8192764 2828993..2829493 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2829493 8192764 METDI2894 Methylobacterium extorquens DM4 hypothetical protein YP_003068408.1 2828993 D 661410 CDS YP_003068409.1 254561314 8192765 2829737..2830342 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; Oxidoreductase, molybdopterin binding 2830342 8192765 METDI2895 Methylobacterium extorquens DM4 Oxidoreductase, molybdopterin binding YP_003068409.1 2829737 D 661410 CDS YP_003068410.1 254561315 8192766 2830347..2831087 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative oxidoreductase, FAD-binding domain 2831087 8192766 METDI2896 Methylobacterium extorquens DM4 putative oxidoreductase, FAD-binding domain YP_003068410.1 2830347 D 661410 CDS YP_003068411.1 254561316 8192767 complement(2831256..2831597) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2831597 8192767 METDI2897 Methylobacterium extorquens DM4 hypothetical protein YP_003068411.1 2831256 R 661410 CDS YP_003068412.1 254561317 8192768 complement(2831814..2832080) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2832080 8192768 METDI2899 Methylobacterium extorquens DM4 hypothetical protein YP_003068412.1 2831814 R 661410 CDS YP_003068413.1 254561318 8192769 2832512..2833822 1 NC_012988.1 catalyzes the formation of 5-O-(1-carboxyvinyl)-3-phosphoshikimate from phosphoenolpyruvate and 3-phosphoshikimate in tryptophan biosynthesis; 3-phosphoshikimate 1-carboxyvinyltransferase 2833822 aroA 8192769 aroA Methylobacterium extorquens DM4 3-phosphoshikimate 1-carboxyvinyltransferase YP_003068413.1 2832512 D 661410 CDS YP_003068414.1 254561319 8195092 2833819..2834487 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 6281725, 95138007; Product type e : enzyme; cytidine monophosphate (CMP) kinase 2834487 cmk 8195092 cmk Methylobacterium extorquens DM4 cytidine monophosphate (CMP) kinase YP_003068414.1 2833819 D 661410 CDS YP_003068415.1 254561320 8195176 complement(2834499..2834816) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2834816 8195176 METDI2902 Methylobacterium extorquens DM4 hypothetical protein YP_003068415.1 2834499 R 661410 CDS YP_003068416.1 254561321 8196264 2835554..2836912 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2836912 8196264 METDI2903 Methylobacterium extorquens DM4 hypothetical protein YP_003068416.1 2835554 D 661410 CDS YP_003068417.1 254561322 8192771 2836949..2838211 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 14523113, 1761231, 9651492, 9791104; Product type pe : putative enzyme; putative glycosyl transferase 2838211 8192771 METDI2904 Methylobacterium extorquens DM4 putative glycosyl transferase YP_003068417.1 2836949 D 661410 CDS YP_003068418.1 254561323 8192772 complement(2838218..2838994) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; creatininase (creatine amidohydrolase) 2838994 8192772 METDI2905 Methylobacterium extorquens DM4 creatininase (creatine amidohydrolase) YP_003068418.1 2838218 R 661410 CDS YP_003068419.1 254561324 8192773 2839176..2840084 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2840084 8192773 METDI2906 Methylobacterium extorquens DM4 hypothetical protein YP_003068419.1 2839176 D 661410 CDS YP_003068420.1 254561325 8192774 complement(2840068..2840484) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2840484 8192774 METDI2907 Methylobacterium extorquens DM4 hypothetical protein YP_003068420.1 2840068 R 661410 CDS YP_003068421.1 254561326 8192775 complement(2840615..2840818) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 10376822, 11988534; hypothetical protein 2840818 8192775 METDI2908 Methylobacterium extorquens DM4 hypothetical protein YP_003068421.1 2840615 R 661410 CDS YP_003068422.1 254561327 8192776 2841123..2842433 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type pt : putative transporter; putative oxalate/formate antiporter 2842433 oxlT 8192776 oxlT Methylobacterium extorquens DM4 putative oxalate/formate antiporter YP_003068422.1 2841123 D 661410 CDS YP_003068423.1 254561328 8195820 2842430..2843209 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type e : enzyme; Fumarylacetoacetate (FAA) hydrolase family 2843209 8195820 METDI2910 Methylobacterium extorquens DM4 Fumarylacetoacetate (FAA) hydrolase family YP_003068423.1 2842430 D 661410 CDS YP_003068424.1 254561329 8192777 2843315..2844322 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; 2-dehydropantoate 2-reductase (ketopantoate reductase) 2844322 panE 8192777 panE Methylobacterium extorquens DM4 2-dehydropantoate 2-reductase (ketopantoate reductase) YP_003068424.1 2843315 D 661410 CDS YP_003068425.1 254561330 8195825 2844319..2845905 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; putative acyl-coenzyme A synthetase 2845905 8195825 METDI2912 Methylobacterium extorquens DM4 putative acyl-coenzyme A synthetase YP_003068425.1 2844319 D 661410 CDS YP_003068426.1 254561331 8192778 complement(2846469..2846750) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2846750 8192778 METDI2913 Methylobacterium extorquens DM4 hypothetical protein YP_003068426.1 2846469 R 661410 CDS YP_003068427.1 254561332 8192779 complement(2846751..2847005) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2847005 8192779 METDI2914 Methylobacterium extorquens DM4 hypothetical protein YP_003068427.1 2846751 R 661410 CDS YP_003068428.1 254561333 8192780 complement(2847121..2847486) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2847486 8192780 METDI2915 Methylobacterium extorquens DM4 hypothetical protein YP_003068428.1 2847121 R 661410 CDS YP_003068429.1 254561334 8192781 complement(2847617..2848819) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2848819 8192781 METDI2916 Methylobacterium extorquens DM4 hypothetical protein YP_003068429.1 2847617 R 661410 CDS YP_003068430.1 254561335 8192782 2848937..2849839 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type r : regulator; transcriptional activator, LysR family 2849839 phnR 8192782 phnR Methylobacterium extorquens DM4 transcriptional activator, LysR family YP_003068430.1 2848937 D 661410 CDS YP_003068431.1 254561336 8195861 complement(2849823..2850212) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; 4-oxalocrotonate tautomerase 2850212 8195861 METDI2918 Methylobacterium extorquens DM4 4-oxalocrotonate tautomerase YP_003068431.1 2849823 R 661410 CDS YP_003068432.1 254561337 8192783 2850473..2851363 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative carbon-carbon lyase, HpcH/HpaI aldolase/citrate lyase family 2851363 8192783 METDI2919 Methylobacterium extorquens DM4 putative carbon-carbon lyase, HpcH/HpaI aldolase/citrate lyase family YP_003068432.1 2850473 D 661410 CDS YP_003068433.1 254561338 8192784 complement(2851433..2851822) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2851822 8192784 METDI2920 Methylobacterium extorquens DM4 hypothetical protein YP_003068433.1 2851433 R 661410 CDS YP_003068434.1 254561339 8192785 complement(2852048..2852737) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative haloacid dehalogenase family hydrolase 2852737 8192785 METDI2921 Methylobacterium extorquens DM4 putative haloacid dehalogenase family hydrolase YP_003068434.1 2852048 R 661410 CDS YP_003068435.1 254561340 8192786 2852875..2854287 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2854287 8192786 METDI2922 Methylobacterium extorquens DM4 hypothetical protein YP_003068435.1 2852875 D 661410 CDS YP_003068436.1 254561341 8192787 2854300..2854935 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2854935 8192787 METDI2923 Methylobacterium extorquens DM4 hypothetical protein YP_003068436.1 2854300 D 661410 CDS YP_003068437.1 254561342 8192788 complement(2854890..2855852) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type r : regulator; transcriptional regulator, LysR family 2855852 8192788 METDI2924 Methylobacterium extorquens DM4 transcriptional regulator, LysR family YP_003068437.1 2854890 R 661410 CDS YP_003068438.1 254561343 8192789 2855988..2856917 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative dioxygenase/glyoxalase family protein 2856917 8192789 METDI2925 Methylobacterium extorquens DM4 putative dioxygenase/glyoxalase family protein YP_003068438.1 2855988 D 661410 CDS YP_003068439.1 254561344 8192790 2856994..2857623 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2857623 8192790 METDI2926 Methylobacterium extorquens DM4 hypothetical protein YP_003068439.1 2856994 D 661410 CDS YP_003068440.1 254561345 8192791 complement(2857705..2857941) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2857941 8192791 METDI2927 Methylobacterium extorquens DM4 hypothetical protein YP_003068440.1 2857705 R 661410 CDS YP_003068441.1 254561346 8192792 2858219..2858446 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2858446 8192792 METDI2928 Methylobacterium extorquens DM4 hypothetical protein YP_003068441.1 2858219 D 661410 CDS YP_003068442.1 254561347 8192793 2858995..2862474 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2862474 8192793 METDI2929 Methylobacterium extorquens DM4 hypothetical protein YP_003068442.1 2858995 D 661410 CDS YP_003068443.1 254561348 8192794 2862863..2863234 1 NC_012988.1 interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone; located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side; mutations in the S12 gene confer streptomycin resistance; 30S ribosomal protein S12 2863234 rpsL 8192794 rpsL Methylobacterium extorquens DM4 30S ribosomal protein S12 YP_003068443.1 2862863 D 661410 CDS YP_003068444.1 254561349 8196063 2863341..2863811 1 NC_012988.1 binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit; 30S ribosomal protein S7 2863811 rpsG 8196063 rpsG Methylobacterium extorquens DM4 30S ribosomal protein S7 YP_003068444.1 2863341 D 661410 CDS YP_003068445.1 254561350 8196058 2863875..2865950 1 NC_012988.1 EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene; elongation factor G 2865950 fusA 8196058 fusA Methylobacterium extorquens DM4 elongation factor G YP_003068445.1 2863875 D 661410 CDS YP_003068446.1 254561351 8195461 2866004..2867194 1 NC_012988.1 EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu; elongation factor Tu 2867194 tufB 8195461 tufB Methylobacterium extorquens DM4 elongation factor Tu YP_003068446.1 2866004 D 661410 CDS YP_003068447.1 254561352 8196290 2867274..2867582 1 NC_012988.1 NusE; involved in assembly of the 30S subunit; in the ribosome, this protein is involved in the binding of tRNA; in Escherichia coli this protein was also found to be involved in transcription antitermination; NusB/S10 heterodimers bind boxA sequences in the leader RNA of rrn operons which is required for antitermination; binding of NusB/S10 to boxA nucleates assembly of the antitermination complex; 30S ribosomal protein S10 2867582 rpsJ 8196290 rpsJ Methylobacterium extorquens DM4 30S ribosomal protein S10 YP_003068447.1 2867274 D 661410 CDS YP_003068448.1 254561353 8196061 2867633..2868373 1 NC_012988.1 binds directly near the 3' end of the 23S rRNA, where it nucleates assembly of the 50S subunit; essential for peptidyltransferase activity; mutations in this gene confer resistance to tiamulin; 50S ribosomal protein L3 2868373 rplC 8196061 rplC Methylobacterium extorquens DM4 50S ribosomal protein L3 YP_003068448.1 2867633 D 661410 CDS YP_003068449.1 254561354 8196014 2868373..2868993 1 NC_012988.1 L4 is important during the early stages of 50S assembly; it initially binds near the 5' end of the 23S rRNA; 50S ribosomal protein L4 2868993 rplD 8196014 rplD Methylobacterium extorquens DM4 50S ribosomal protein L4 YP_003068449.1 2868373 D 661410 CDS YP_003068450.1 254561355 8196015 2868990..2869286 1 NC_012988.1 binds third domain of 23S rRNA and protein L29; part of exit tunnel; 50S ribosomal protein L23 2869286 rplW 8196015 rplW Methylobacterium extorquens DM4 50S ribosomal protein L23 YP_003068450.1 2868990 D 661410 CDS YP_003068451.1 254561356 8196032 2869312..2870148 1 NC_012988.1 one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation; 50S ribosomal protein L2 2870148 rplB 8196032 rplB Methylobacterium extorquens DM4 50S ribosomal protein L2 YP_003068451.1 2869312 D 661410 CDS YP_003068452.1 254561357 8196013 2870154..2870432 1 NC_012988.1 protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA; 30S ribosomal protein S19 2870432 rpsS 8196013 rpsS Methylobacterium extorquens DM4 30S ribosomal protein S19 YP_003068452.1 2870154 D 661410 CDS YP_003068453.1 254561358 8196070 2870434..2870817 1 NC_012988.1 binds specifically to 23S rRNA during the early stages of 50S assembly; makes contact with all 6 domains of the 23S rRNA in the assembled 50S subunit and ribosome; mutations in this gene result in erythromycin resistance; located near peptidyl-transferase center; 50S ribosomal protein L22 2870817 rplV 8196070 rplV Methylobacterium extorquens DM4 50S ribosomal protein L22 YP_003068453.1 2870434 D 661410 CDS YP_003068454.1 254561359 8196031 2870829..2871575 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 10094780, 12244297, 12809609, 387449, 389248, 89263724, 92345329, 93011980; Product type s : structure; 30S ribosomal subunit protein S3 2871575 rpsC 8196031 rpsC Methylobacterium extorquens DM4 30S ribosomal subunit protein S3 YP_003068454.1 2870829 D 661410 CDS YP_003068455.1 254561360 8196054 2871609..2872022 1 NC_012988.1 located in the peptidyl transferase center and may be involved in peptidyl transferase activity; similar to archaeal L10e; 50S ribosomal protein L16 2872022 rplP 8196054 rplP Methylobacterium extorquens DM4 50S ribosomal protein L16 YP_003068455.1 2871609 D 661410 CDS YP_003068456.1 254561361 8196025 2872035..2872250 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 10094780, 1092361, 12809609, 3892488, 89287320, 91088242; Product type s : structure; 50S ribosomal subunit protein L29 2872250 rpmC 8196025 rpmC Methylobacterium extorquens DM4 50S ribosomal subunit protein L29 YP_003068456.1 2872035 D 661410 CDS YP_003068457.1 254561362 8196037 2872262..2872528 1 NC_012988.1 primary binding protein; helps mediate assembly; involved in translation fidelity; 30S ribosomal protein S17 2872528 rpsQ 8196037 rpsQ Methylobacterium extorquens DM4 30S ribosomal protein S17 YP_003068457.1 2872262 D 661410 CDS YP_003068458.1 254561363 8196068 2872901..2874289 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2874289 8196068 METDI2945 Methylobacterium extorquens DM4 hypothetical protein YP_003068458.1 2872901 D 661410 CDS YP_003068459.1 254561364 8192795 complement(2874503..2874961) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2874961 8192795 METDI2946 Methylobacterium extorquens DM4 hypothetical protein YP_003068459.1 2874503 R 661410 CDS YP_003068460.1 254561365 8192796 complement(2875207..2875671) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type r : regulator; transcriptional regulator, MarR family 2875671 8192796 METDI2947 Methylobacterium extorquens DM4 transcriptional regulator, MarR family YP_003068460.1 2875207 R 661410 CDS YP_003068461.1 254561366 8192797 complement(2875961..2876377) 1 NC_012988.1 is a component of the macrolide binding site in the peptidyl transferase center; 50S ribosomal protein L17 2876377 rplQ 8192797 rplQ Methylobacterium extorquens DM4 50S ribosomal protein L17 YP_003068461.1 2875961 R 661410 CDS YP_003068462.1 254561367 8196026 complement(2876608..2877627) 1 NC_012988.1 catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme; DNA-directed RNA polymerase subunit alpha 2877627 rpoA 8196026 rpoA Methylobacterium extorquens DM4 DNA-directed RNA polymerase subunit alpha YP_003068462.1 2876608 R 661410 CDS YP_003068463.1 254561368 8196044 complement(2877726..2878607) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative metallo-beta-lactamase family protein 2878607 8196044 METDI2950 Methylobacterium extorquens DM4 putative metallo-beta-lactamase family protein YP_003068463.1 2877726 R 661410 CDS YP_003068464.1 254561369 8192798 complement(2878645..2879034) 1 NC_012988.1 located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA; forms part of the Shine-Dalgarno cleft in the 70S ribosome; interacts with S7 and S18 and IF-3; 30S ribosomal protein S11 2879034 rpsK 8192798 rpsK Methylobacterium extorquens DM4 30S ribosomal protein S11 YP_003068464.1 2878645 R 661410 CDS YP_003068465.1 254561370 8196062 complement(2879205..2879573) 1 NC_012988.1 located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA; makes contact with the large subunit via RNA-protein interactions and via protein-protein interactions with L5; contacts P-site tRNA; 30S ribosomal protein S13 2879573 rpsM 8196062 rpsM Methylobacterium extorquens DM4 30S ribosomal protein S13 YP_003068465.1 2879205 R 661410 CDS YP_003068466.1 254561371 8196064 complement(2879877..2880479) 1 NC_012988.1 essential enzyme that recycles AMP in active cells; converts ATP and AMP to two molecules of ADP; adenylate kinase 2880479 adk 8196064 adk Methylobacterium extorquens DM4 adenylate kinase YP_003068466.1 2879877 R 661410 CDS YP_003068467.1 254561372 8195064 complement(2880650..2881993) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 10348856, 1633829, 200755, 92156163, 92202287, 92339472, 9564033, 99298179; Product type t : transporter; preprotein translocase, membrane component, transport across inner membrane (General Secretory Pathway) 2881993 secY 8195064 secY Methylobacterium extorquens DM4 preprotein translocase, membrane component, transport across inner membrane (General Secretory Pathway) YP_003068467.1 2880650 R 661410 CDS YP_003068468.1 254561373 8196108 complement(2882108..2882617) 1 NC_012988.1 late assembly protein; 50S ribosomal protein L15 2882617 rplO 8196108 rplO Methylobacterium extorquens DM4 50S ribosomal protein L15 YP_003068468.1 2882108 R 661410 CDS YP_003068469.1 254561374 8196024 complement(2882631..2882825) 1 NC_012988.1 L30 binds domain II of the 23S rRNA and the 5S rRNA; similar to eukaryotic protein L7; 50S ribosomal protein L30 2882825 rpmD 8196024 rpmD Methylobacterium extorquens DM4 50S ribosomal protein L30 YP_003068469.1 2882631 R 661410 CDS YP_003068470.1 254561375 8196038 complement(2882837..2883415) 1 NC_012988.1 located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body; contacts S4 and S8; with S4 and S12 plays a role in translational accuracy; mutations in this gene result in spectinomycin resistance; 30S ribosomal protein S5 2883415 rpsE 8196038 rpsE Methylobacterium extorquens DM4 30S ribosomal protein S5 YP_003068470.1 2882837 R 661410 CDS YP_003068471.1 254561376 8196056 complement(2883506..2883868) 1 NC_012988.1 binds 5S rRNA along with protein L5 and L25; 50S ribosomal protein L18 2883868 rplR 8196056 rplR Methylobacterium extorquens DM4 50S ribosomal protein L18 YP_003068471.1 2883506 R 661410 CDS YP_003068472.1 254561377 8196027 complement(2883880..2884413) 1 NC_012988.1 ribosomal protein L6 appears to have arisen as a result of an ancient gene duplication as based on structural comparison of the Bacillus stearothermophilus protein; RNA-binding appears to be in the C-terminal domain; mutations in the L6 gene confer resistance to aminoglycoside antibiotics such as gentamicin and these occur in truncations of the C-terminal domain; it has been localized to a region between the base of the L7/L12 stalk and the central protuberance; 50S ribosomal protein L6 2884413 rplF 8196027 rplF Methylobacterium extorquens DM4 50S ribosomal protein L6 YP_003068472.1 2883880 R 661410 CDS YP_003068473.1 254561378 8196017 complement(2884430..2884825) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 10094780, 12244297, 12809609, 1735715, 36569, 89098950, 90096156, 93257440; Product type s : structure; 30S ribosomal subunit protein S8, and regulator 2884825 rpsH 8196017 rpsH Methylobacterium extorquens DM4 30S ribosomal subunit protein S8, and regulator YP_003068473.1 2884430 R 661410 CDS YP_003068474.1 254561379 8196059 complement(2884838..2885143) 1 NC_012988.1 located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group do not appear to have the zinc-binding motif; 30S ribosomal protein S14 2885143 rpsN 8196059 rpsN Methylobacterium extorquens DM4 30S ribosomal protein S14 YP_003068474.1 2884838 R 661410 CDS YP_003068475.1 254561380 8196065 complement(2885185..2885751) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 89313662; Product type s : structure; 50S ribosomal subunit protein L5 2885751 rplE 8196065 rplE Methylobacterium extorquens DM4 50S ribosomal subunit protein L5 YP_003068475.1 2885185 R 661410 CDS YP_003068476.1 254561381 8196016 complement(2885744..2886058) 1 NC_012988.1 assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel; 50S ribosomal protein L24 2886058 rplX 8196016 rplX Methylobacterium extorquens DM4 50S ribosomal protein L24 YP_003068476.1 2885744 R 661410 CDS YP_003068477.1 254561382 8196033 complement(2886058..2886426) 1 NC_012988.1 binds to the 23S rRNA between the centers for peptidyl transferase and GTPase; 50S ribosomal protein L14 2886426 rplN 8196033 rplN Methylobacterium extorquens DM4 50S ribosomal protein L14 YP_003068477.1 2886058 R 661410 CDS YP_003068478.1 254561383 8196023 complement(2886780..2887061) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2887061 8196023 METDI2966 Methylobacterium extorquens DM4 hypothetical protein YP_003068478.1 2886780 R 661410 CDS YP_003068479.1 254561384 8192799 complement(2887370..2887903) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2887903 8192799 METDI2967 Methylobacterium extorquens DM4 hypothetical protein YP_003068479.1 2887370 R 661410 CDS YP_003068480.1 254561385 8192800 2888506..2888886 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2888886 8192800 METDI2968 Methylobacterium extorquens DM4 hypothetical protein YP_003068480.1 2888506 D 661410 CDS YP_003068481.1 254561386 8192801 2889000..2890247 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative diguanylate cyclase (GGDEF domain) 2890247 8192801 METDI2969 Methylobacterium extorquens DM4 putative diguanylate cyclase (GGDEF domain) YP_003068481.1 2889000 D 661410 CDS YP_003068482.1 254561387 8192802 2890338..2891408 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2891408 8192802 METDI2970 Methylobacterium extorquens DM4 hypothetical protein YP_003068482.1 2890338 D 661410 CDS YP_003068483.1 254561388 8192803 complement(2891473..2891913) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2891913 8192803 METDI2971 Methylobacterium extorquens DM4 hypothetical protein YP_003068483.1 2891473 R 661410 CDS YP_003068484.1 254561389 8192804 2892112..2892324 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 2892324 8192804 METDI2972 Methylobacterium extorquens DM4 hypothetical protein YP_003068484.1 2892112 D 661410 CDS YP_003068485.1 254561390 8192805 complement(2892321..2892617) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2892617 8192805 METDI2973 Methylobacterium extorquens DM4 hypothetical protein YP_003068485.1 2892321 R 661410 CDS YP_003068486.1 254561391 8192806 2892901..2893158 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2893158 8192806 METDI2974 Methylobacterium extorquens DM4 hypothetical protein YP_003068486.1 2892901 D 661410 CDS YP_003068487.1 254561392 8192807 2893415..2893684 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2893684 8192807 METDI2975 Methylobacterium extorquens DM4 hypothetical protein YP_003068487.1 2893415 D 661410 CDS YP_003068488.1 254561393 8196242 complement(2894008..2895195) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8561793, 8695632; Product type pe : putative enzyme; putative salicylate hydroxylase, Salicylate 1-monooxygenase, nahG 2895195 8196242 METDI2976 Methylobacterium extorquens DM4 putative salicylate hydroxylase, Salicylate 1-monooxygenase, nahG YP_003068488.1 2894008 R 661410 CDS YP_003068489.1 254561394 8192809 complement(2895211..2895477) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2895477 8192809 METDI2977 Methylobacterium extorquens DM4 hypothetical protein YP_003068489.1 2895211 R 661410 CDS YP_003068490.1 254561395 8192810 2895864..2896349 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2896349 8192810 METDI2978 Methylobacterium extorquens DM4 hypothetical protein YP_003068490.1 2895864 D 661410 CDS YP_003068491.1 254561396 8192811 2896376..2896582 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type pr : putative regulator; transcriptional regulator, XRE family 2896582 8192811 METDI2979 Methylobacterium extorquens DM4 transcriptional regulator, XRE family YP_003068491.1 2896376 D 661410 CDS YP_003068492.1 254561397 8192812 2896640..2897911 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2897911 8192812 METDI2980 Methylobacterium extorquens DM4 hypothetical protein YP_003068492.1 2896640 D 661410 CDS YP_003068493.1 254561398 8192813 2898013..2898867 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 10387007, 3027045, 8471602; Product type e : enzyme; methionine aminopeptidase 2898867 map 8192813 map Methylobacterium extorquens DM4 methionine aminopeptidase YP_003068493.1 2898013 D 661410 CDS YP_003068494.1 254561399 8195661 2898882..2899628 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 10652786, 11743193, 11743194; Product type cp : cell process; DNA repair protein RadC 2899628 radC 8195661 radC Methylobacterium extorquens DM4 DNA repair protein RadC YP_003068494.1 2898882 D 661410 CDS YP_003068495.1 254561400 8195960 2899944..2901383 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2901383 8195960 METDI2983 Methylobacterium extorquens DM4 hypothetical protein YP_003068495.1 2899944 D 661410 CDS YP_003068496.1 254561401 8192814 2901491..2902435 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2902435 8192814 METDI2984 Methylobacterium extorquens DM4 hypothetical protein YP_003068496.1 2901491 D 661410 CDS YP_003068497.1 254561402 8192815 complement(2902536..2902790) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2902790 8192815 METDI2985 Methylobacterium extorquens DM4 hypothetical protein YP_003068497.1 2902536 R 661410 CDS YP_003068498.1 254561403 8192816 complement(2902831..2903280) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2903280 8192816 METDI2986 Methylobacterium extorquens DM4 hypothetical protein YP_003068498.1 2902831 R 661410 CDS YP_003068499.1 254561404 8192817 complement(2903288..2903665) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2903665 8192817 METDI2987 Methylobacterium extorquens DM4 hypothetical protein YP_003068499.1 2903288 R 661410 CDS YP_003068500.1 254561405 8192818 2903307..2903603 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2903603 8192818 METDI2988 Methylobacterium extorquens DM4 hypothetical protein YP_003068500.1 2903307 D 661410 CDS YP_003068501.1 254561406 8192819 2903894..2904382 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2904382 8192819 METDI2989 Methylobacterium extorquens DM4 hypothetical protein YP_003068501.1 2903894 D 661410 CDS YP_003068502.1 254561407 8192820 2904749..2905639 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; Transglutaminase-like domain 2905639 8192820 METDI2990 Methylobacterium extorquens DM4 Transglutaminase-like domain YP_003068502.1 2904749 D 661410 CDS YP_003068503.1 254561408 8192821 2905706..2906509 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2906509 8192821 METDI2991 Methylobacterium extorquens DM4 hypothetical protein YP_003068503.1 2905706 D 661410 CDS YP_003068504.1 254561409 8192822 complement(2906624..2907343) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 10381378, 10811920, 15019790, 22586414, 8955330, 9822644; Product type e : enzyme; NAD-dependent protein deacetylase, regulatory protein SIR2 family 2907343 cobB 8192822 cobB Methylobacterium extorquens DM4 NAD-dependent protein deacetylase, regulatory protein SIR2 family YP_003068504.1 2906624 R 661410 CDS YP_003068505.1 254561410 8195183 complement(2907340..2908554) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; putative inner membrane protein (UPF0053 family) with 2 CBS domains 2908554 8195183 METDI2993 Methylobacterium extorquens DM4 putative inner membrane protein (UPF0053 family) with 2 CBS domains YP_003068505.1 2907340 R 661410 CDS YP_003068506.1 254561411 8192823 2909033..2912101 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2912101 8192823 METDI2994 Methylobacterium extorquens DM4 hypothetical protein YP_003068506.1 2909033 D 661410 CDS YP_003068507.1 254561412 8192824 2912193..2912423 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2912423 8192824 METDI2995 Methylobacterium extorquens DM4 hypothetical protein YP_003068507.1 2912193 D 661410 CDS YP_003068509.1 254561414 8192826 complement(2912546..2912797) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2912797 8192826 METDI2997 Methylobacterium extorquens DM4 hypothetical protein YP_003068509.1 2912546 R 661410 CDS YP_003068510.1 254561415 8192827 complement(2913082..2914548) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; serine protease precursor 2914548 8192827 METDI2998 Methylobacterium extorquens DM4 serine protease precursor YP_003068510.1 2913082 R 661410 CDS YP_003068511.1 254561416 8192828 complement(2914881..2915633) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2915633 8192828 METDI2999 Methylobacterium extorquens DM4 hypothetical protein YP_003068511.1 2914881 R 661410 CDS YP_003068512.1 254561417 8192829 complement(2915798..2916154) 1 NC_012988.1 Evidence 1c : Function experimentally demonstrated in the studied genus; Product type f : factor; Granule-associated 11 kDa protein 2916154 gap11 8192829 gap11 Methylobacterium extorquens DM4 Granule-associated 11 kDa protein YP_003068512.1 2915798 R 661410 CDS YP_003068513.1 254561418 8195465 complement(2916383..2917687) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative glycosyl transferase 2917687 8195465 METDI3001 Methylobacterium extorquens DM4 putative glycosyl transferase YP_003068513.1 2916383 R 661410 CDS YP_003068514.1 254561419 8192830 2917902..2919173 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative glycosyl transferase 2919173 8192830 METDI3002 Methylobacterium extorquens DM4 putative glycosyl transferase YP_003068514.1 2917902 D 661410 CDS YP_003068515.1 254561420 8192831 2919261..2919440 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2919440 8192831 METDI3003 Methylobacterium extorquens DM4 hypothetical protein YP_003068515.1 2919261 D 661410 CDS YP_003068516.1 254561421 8192832 complement(2919475..2921808) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type prc : putative receptor; putative diguanylate cyclase (GGDEF) /phosphodiesterase (EAL) with PAS sensor 2921808 8192832 METDI3004 Methylobacterium extorquens DM4 putative diguanylate cyclase (GGDEF) /phosphodiesterase (EAL) with PAS sensor YP_003068516.1 2919475 R 661410 CDS YP_003068517.1 254561422 8192833 complement(2922033..2923721) 1 NC_012988.1 Evidence 1c : Function experimentally demonstrated in the studied genus; PubMedId : 16856937, 17548827; Product type e : enzyme; methylsuccinyl-CoA dehydrogenase 2923721 msd 8192833 msd Methylobacterium extorquens DM4 methylsuccinyl-CoA dehydrogenase YP_003068517.1 2922033 R 661410 CDS YP_003068518.1 254561423 8195726 complement(2923884..2924774) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2924774 8195726 METDI3006 Methylobacterium extorquens DM4 hypothetical protein YP_003068518.1 2923884 R 661410 CDS YP_003068519.1 254561424 8192834 2924927..2925829 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative ribonuclease RNAse BN 2925829 8192834 METDI3007 Methylobacterium extorquens DM4 putative ribonuclease RNAse BN YP_003068519.1 2924927 D 661410 CDS YP_003068520.1 254561425 8192835 complement(2925741..2926781) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2926781 8192835 METDI3008 Methylobacterium extorquens DM4 hypothetical protein YP_003068520.1 2925741 R 661410 CDS YP_003068521.1 254561426 8192836 complement(2926967..2928376) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 1316900, 2828368, 88115389, 92112707, 92268080; Product type e : enzyme; ATP-sulfurylase, subunit 1 (ATP:sulfate adenylyltransferase) 2928376 cysN 8192836 cysN Methylobacterium extorquens DM4 ATP-sulfurylase, subunit 1 (ATP:sulfate adenylyltransferase) YP_003068521.1 2926967 R 661410 CDS YP_003068522.1 254561427 8195259 complement(2928376..2929305) 1 NC_012988.1 with CysN catalyzes the formation of adenylylsulfate from sulfate and ATP; sulfate adenylyltransferase subunit 2 2929305 cysD 8195259 cysD Methylobacterium extorquens DM4 sulfate adenylyltransferase subunit 2 YP_003068522.1 2928376 R 661410 CDS YP_003068523.1 254561428 8195250 complement(2929305..2930114) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 10464198, 11481430; Product type e : enzyme; Phosphoadenosine phosphosulfate reductase (PAPS reductase, thioredoxin dependent) (PAdoPS reductase) (3'-phosphoadenylyl-sulfate reductase) (PAPS sulfotransferase) 2930114 cysH 8195250 cysH Methylobacterium extorquens DM4 Phosphoadenosine phosphosulfate reductase (PAPS reductase, thioredoxin dependent) (PAdoPS reductase) (3'-phosphoadenylyl-sulfate reductase) (PAPS sulfotransferase) YP_003068523.1 2929305 R 661410 CDS YP_003068524.1 254561429 8195254 2930379..2930882 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcriptional regulator, AsnC/Lrp family 2930882 8195254 METDI3012 Methylobacterium extorquens DM4 putative transcriptional regulator, AsnC/Lrp family YP_003068524.1 2930379 D 661410 CDS YP_003068525.1 254561430 8192837 2930995..2932770 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 16738553, 2550423, 2670946, 7589518, 7657631, 9153434, 9278503, 9618257; Product type e : enzyme; sulfite reductase, alpha subunit (flavoprotein) 2932770 cysJ 8192837 cysJ Methylobacterium extorquens DM4 sulfite reductase, alpha subunit (flavoprotein) YP_003068525.1 2930995 D 661410 CDS YP_003068526.1 254561431 8195256 2932957..2934795 1 NC_012988.1 hemoprotein; NADPH dependent; with the alpha subunit (a flavoprotein) catalyzes the reduction of sulfite to sulfide; sulfite reductase subunit beta 2934795 cysI 8195256 cysI Methylobacterium extorquens DM4 sulfite reductase subunit beta YP_003068526.1 2932957 D 661410 CDS YP_003068527.1 254561432 8195255 complement(2934859..2937039) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type prc : putative receptor; putative TonB-dependent receptor 2937039 8195255 METDI3015 Methylobacterium extorquens DM4 putative TonB-dependent receptor YP_003068527.1 2934859 R 661410 CDS YP_003068528.1 254561433 8192838 complement(2937374..2938231) 1 NC_012988.1 catalyzes the formation of (R)-pantothenate from pantoate and beta-alanine; pantoate--beta-alanine ligase 2938231 panC 8192838 panC Methylobacterium extorquens DM4 pantoate--beta-alanine ligase YP_003068528.1 2937374 R 661410 CDS YP_003068529.1 254561434 8195824 complement(2938307..2938666) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2938666 8195824 METDI3017 Methylobacterium extorquens DM4 hypothetical protein YP_003068529.1 2938307 R 661410 CDS YP_003068530.1 254561435 8192839 complement(2938739..2939344) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcriptional regulator, XRE family 2939344 8192839 METDI3018 Methylobacterium extorquens DM4 putative transcriptional regulator, XRE family YP_003068530.1 2938739 R 661410 CDS YP_003068531.1 254561436 8192840 complement(2939721..2940287) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type cp : cell process; Single-stranded DNA-binding protein 2940287 ssb 8192840 ssb Methylobacterium extorquens DM4 Single-stranded DNA-binding protein YP_003068531.1 2939721 R 661410 CDS YP_003068532.1 254561437 8196147 complement(2940592..2941608) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative conserved oxidoreductase, Zn-dependent and NAD(P)-binding 2941608 yncB 8196147 yncB Methylobacterium extorquens DM4 putative conserved oxidoreductase, Zn-dependent and NAD(P)-binding YP_003068532.1 2940592 R 661410 CDS YP_003068533.1 254561438 8196375 2941701..2942108 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2942108 8196375 METDI3022 Methylobacterium extorquens DM4 hypothetical protein YP_003068533.1 2941701 D 661410 CDS YP_003068534.1 254561439 8192841 complement(2942161..2942700) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2942700 8192841 METDI3023 Methylobacterium extorquens DM4 hypothetical protein YP_003068534.1 2942161 R 661410 CDS YP_003068535.1 254561440 8192842 2942927..2943703 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2943703 8192842 METDI3024 Methylobacterium extorquens DM4 hypothetical protein YP_003068535.1 2942927 D 661410 CDS YP_003068536.1 254561441 8192843 complement(2943862..2944980) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16109935; Product type pe : putative enzyme; putative NADH:flavin oxidoreductase/NADH oxidase 2944980 8192843 METDI3025 Methylobacterium extorquens DM4 putative NADH:flavin oxidoreductase/NADH oxidase YP_003068536.1 2943862 R 661410 CDS YP_003068537.1 254561442 8192846 2946211..2946726 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2946726 8192846 METDI3028 Methylobacterium extorquens DM4 hypothetical protein YP_003068537.1 2946211 D 661410 CDS YP_003068538.1 254561443 8192847 2946963..2947871 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type c : carrier; thioredoxin 2947871 trx 8192847 trx Methylobacterium extorquens DM4 thioredoxin YP_003068538.1 2946963 D 661410 CDS YP_003068539.1 254561444 8196283 2947957..2948625 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10583374, 10877760, 12123452; Product type pe : putative enzyme; putative Lon family ATP-dependent protease 2948625 8196283 METDI3030 Methylobacterium extorquens DM4 putative Lon family ATP-dependent protease YP_003068539.1 2947957 D 661410 CDS YP_003068540.1 254561445 8192848 2948683..2948889 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2948889 8192848 METDI3031 Methylobacterium extorquens DM4 hypothetical protein YP_003068540.1 2948683 D 661410 CDS YP_003068541.1 254561446 8192849 complement(2949044..2950003) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2950003 8192849 METDI3032 Methylobacterium extorquens DM4 hypothetical protein YP_003068541.1 2949044 R 661410 CDS YP_003068542.1 254561447 8192850 2949783..2950079 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2950079 8192850 METDI3033 Methylobacterium extorquens DM4 hypothetical protein YP_003068542.1 2949783 D 661410 CDS YP_003068543.1 254561448 8192851 complement(2950204..2951319) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2951319 8192851 METDI3034 Methylobacterium extorquens DM4 hypothetical protein YP_003068543.1 2950204 R 661410 CDS YP_003068544.1 254561449 8192852 complement(2951441..2952145) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2952145 8192852 METDI3035 Methylobacterium extorquens DM4 hypothetical protein YP_003068544.1 2951441 R 661410 CDS YP_003068545.1 254561450 8192853 complement(2952352..2953011) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative transglutaminase-like cysteine peptidase precursor 2953011 8192853 METDI3036 Methylobacterium extorquens DM4 putative transglutaminase-like cysteine peptidase precursor YP_003068545.1 2952352 R 661410 CDS YP_003068546.1 254561451 8192854 complement(2953455..2954054) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2954054 8192854 METDI3037 Methylobacterium extorquens DM4 hypothetical protein YP_003068546.1 2953455 R 661410 CDS YP_003068547.1 254561452 8192855 complement(2954287..2954919) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2954919 8192855 METDI3038 Methylobacterium extorquens DM4 hypothetical protein YP_003068547.1 2954287 R 661410 CDS YP_003068548.1 254561453 8192856 2955148..2955972 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative rhomboid-like protein 2955972 8192856 METDI3039 Methylobacterium extorquens DM4 putative rhomboid-like protein YP_003068548.1 2955148 D 661410 CDS YP_003068549.1 254561454 8192857 2956214..2956654 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 2956654 8192857 METDI3040 Methylobacterium extorquens DM4 hypothetical protein YP_003068549.1 2956214 D 661410 CDS YP_003068550.1 254561455 8192858 2956270..2957100 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10433972; Product type pf : putative factor; putative CoxB-related 2957100 8192858 METDI3041 Methylobacterium extorquens DM4 putative CoxB-related YP_003068550.1 2956270 D 661410 CDS YP_003068551.1 254561456 8192859 complement(2957072..2957368) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2957368 8192859 METDI3042 Methylobacterium extorquens DM4 hypothetical protein YP_003068551.1 2957072 R 661410 CDS YP_003068552.1 254561457 8192860 2957459..2957890 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2957890 8192860 METDI3043 Methylobacterium extorquens DM4 hypothetical protein YP_003068552.1 2957459 D 661410 CDS YP_003068553.1 254561458 8192861 complement(2957943..2959001) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type e : enzyme; putative patatin-like esterase 2959001 8192861 METDI3044 Methylobacterium extorquens DM4 putative patatin-like esterase YP_003068553.1 2957943 R 661410 CDS YP_003068554.1 254561459 8192862 complement(2958998..2959420) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; phosphoribosyl c-AMP cyclohydrolase 2959420 hisI 8192862 hisI Methylobacterium extorquens DM4 phosphoribosyl c-AMP cyclohydrolase YP_003068554.1 2958998 R 661410 CDS YP_003068555.1 254561460 8195565 complement(2959440..2960249) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 12730156; Product type e : enzyme; GTP cyclohydrolase I 2960249 folE 8195565 folE Methylobacterium extorquens DM4 GTP cyclohydrolase I YP_003068555.1 2959440 R 661410 CDS YP_003068556.1 254561461 8195437 2960473..2960946 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2960946 8195437 METDI3048 Methylobacterium extorquens DM4 hypothetical protein YP_003068556.1 2960473 D 661410 CDS YP_003068557.1 254561462 8192863 2961018..2961338 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2961338 8192863 METDI3049 Methylobacterium extorquens DM4 hypothetical protein YP_003068557.1 2961018 D 661410 CDS YP_003068558.1 254561463 8192864 complement(2961496..2962263) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pt : putative transporter; hypothetical protein 2962263 ybhL 8192864 ybhL Methylobacterium extorquens DM4 hypothetical protein YP_003068558.1 2961496 R 661410 CDS YP_003068559.1 254561464 8196352 complement(2962481..2965063) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2965063 8196352 METDI3051 Methylobacterium extorquens DM4 hypothetical protein YP_003068559.1 2962481 R 661410 CDS YP_003068560.1 254561465 8192865 complement(2965176..2966591) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type prc : putative receptor; putative integral membrane sensor signal transduction histidine kinase precursor 2966591 8192865 METDI3052 Methylobacterium extorquens DM4 putative integral membrane sensor signal transduction histidine kinase precursor YP_003068560.1 2965176 R 661410 CDS YP_003068561.1 254561466 8192866 2966733..2967482 1 NC_012988.1 involved in the de novo synthesis of pyridoxine (Vitamin B6); pyridoxine 5'-phosphate synthase 2967482 pdxJ 8192866 pdxJ Methylobacterium extorquens DM4 pyridoxine 5'-phosphate synthase YP_003068561.1 2966733 D 661410 CDS YP_003068562.1 254561467 8195842 2967479..2967889 1 NC_012988.1 Catalyzes the formation of holo-ACP, which mediates the essential transfer of acyl fatty acid intermediates during the biosynthesis of fatty acids and lipids; 4'-phosphopantetheinyl transferase 2967889 acpS 8195842 acpS Methylobacterium extorquens DM4 4'-phosphopantetheinyl transferase YP_003068562.1 2967479 D 661410 CDS YP_003068563.1 254561468 8195051 2968019..2968825 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 9870699; Product type e : enzyme; signal peptidase I (SPase I) (leader peptidase I) 2968825 8195051 METDI3055 Methylobacterium extorquens DM4 signal peptidase I (SPase I) (leader peptidase I) YP_003068563.1 2968019 D 661410 CDS YP_003068564.1 254561469 8192867 2968886..2969656 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 14704707; Product type e : enzyme; ribonuclease III 2969656 rnc 8192867 rnc Methylobacterium extorquens DM4 ribonuclease III YP_003068564.1 2968886 D 661410 CDS YP_003068565.1 254561470 8196001 2969677..2970657 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 12597275, 9870699; Product type e : enzyme; GTP-binding protein 2970657 era 8196001 era Methylobacterium extorquens DM4 GTP-binding protein YP_003068565.1 2969677 D 661410 CDS YP_003068566.1 254561471 8195332 2970853..2971779 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative methyltransferase 2971779 8195332 METDI3058 Methylobacterium extorquens DM4 putative methyltransferase YP_003068566.1 2970853 D 661410 CDS YP_003068567.1 254561472 8192868 2971776..2972504 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 10376875, 11953756, 7612632; Product type e : enzyme; 16S rRNA pseudouridylate 516 synthase 2972504 rsuA 8192868 rsuA Methylobacterium extorquens DM4 16S rRNA pseudouridylate 516 synthase YP_003068567.1 2971776 D 661410 CDS YP_003068568.1 254561473 8196090 complement(2972509..2973150) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2973150 8196090 METDI3060 Methylobacterium extorquens DM4 hypothetical protein YP_003068568.1 2972509 R 661410 CDS YP_003068569.1 254561474 8192869 2973374..2974768 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2974768 8192869 METDI3061 Methylobacterium extorquens DM4 hypothetical protein YP_003068569.1 2973374 D 661410 CDS YP_003068570.1 254561475 8192870 2974969..2975760 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2975760 8192870 METDI3062 Methylobacterium extorquens DM4 hypothetical protein YP_003068570.1 2974969 D 661410 CDS YP_003068571.1 254561476 8192871 2975971..2976276 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2976276 8192871 METDI3063 Methylobacterium extorquens DM4 hypothetical protein YP_003068571.1 2975971 D 661410 CDS YP_003068572.1 254561477 8192872 complement(2976284..2978212) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 89197799, 94042856, 99229748; Product type t : transporter; potassium uptake protein Kup 2978212 kup1 8192872 kup1 Methylobacterium extorquens DM4 potassium uptake protein Kup YP_003068572.1 2976284 R 661410 CDS YP_003068573.1 254561478 8195625 complement(2978412..2979068) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2979068 8195625 METDI3065 Methylobacterium extorquens DM4 hypothetical protein YP_003068573.1 2978412 R 661410 CDS YP_003068574.1 254561479 8192873 complement(2979096..2979683) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 10760174, 11479323, 14594825, 21474313; Product type pe : putative enzyme; (di)nucleoside polyphosphate hydrolase (Nudix family) 2979683 8192873 METDI3066 Methylobacterium extorquens DM4 (di)nucleoside polyphosphate hydrolase (Nudix family) YP_003068574.1 2979096 R 661410 CDS YP_003068575.1 254561480 8192874 complement(2979828..2981516) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type prc : putative receptor; putative methyl-accepting chemotaxis sensory transducer 2981516 8192874 METDI3067 Methylobacterium extorquens DM4 putative methyl-accepting chemotaxis sensory transducer YP_003068575.1 2979828 R 661410 CDS YP_003068576.1 254561481 8192875 complement(2981877..2983106) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2983106 8192875 METDI3068 Methylobacterium extorquens DM4 hypothetical protein YP_003068576.1 2981877 R 661410 CDS YP_003068577.1 254561482 8192876 complement(2983234..2984595) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative periplasmic carboxyl-terminal processing protease 2984595 8192876 METDI3069 Methylobacterium extorquens DM4 putative periplasmic carboxyl-terminal processing protease YP_003068577.1 2983234 R 661410 CDS YP_003068578.1 254561483 8192877 complement(2984556..2985956) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative membrane-bound metallopeptidase 2985956 8192877 METDI3070 Methylobacterium extorquens DM4 putative membrane-bound metallopeptidase YP_003068578.1 2984556 R 661410 CDS YP_003068579.1 254561484 8192878 complement(2985953..2986450) 1 NC_012988.1 SPOUT methyltransferase family protein; crystal structure shows homodimer; in Escherichia coli this protein methylates pseudouridine at position 1915 of the 23S ribosomal RNA; rRNA large subunit methyltransferase 2986450 8192878 METDI3071 Methylobacterium extorquens DM4 rRNA large subunit methyltransferase YP_003068579.1 2985953 R 661410 CDS YP_003068580.1 254561485 8192879 2986698..2988008 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type t : transporter; MFS transporter membrane protein 2988008 8192879 METDI3072 Methylobacterium extorquens DM4 MFS transporter membrane protein YP_003068580.1 2986698 D 661410 CDS YP_003068581.1 254561486 8192880 2988289..2990238 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative diguanylate cyclase/phosphodiesterase (GGDEF and EAL motifs) 2990238 8192880 METDI3073 Methylobacterium extorquens DM4 putative diguanylate cyclase/phosphodiesterase (GGDEF and EAL motifs) YP_003068581.1 2988289 D 661410 CDS YP_003068582.1 254561487 8192881 complement(2990243..2990869) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; periplasmic oxidoreductase, DsbA family 2990869 8192881 METDI3074 Methylobacterium extorquens DM4 periplasmic oxidoreductase, DsbA family YP_003068582.1 2990243 R 661410 CDS YP_003068583.1 254561488 8192882 2991044..2992285 1 NC_012988.1 catalyzes the formation of 2-N(omega)-(L-arginino)succinate from L-citrulline and L-aspartate in arginine biosynthesis, AMP-forming; argininosuccinate synthase 2992285 argG 8192882 argG Methylobacterium extorquens DM4 argininosuccinate synthase YP_003068583.1 2991044 D 661410 CDS YP_003068584.1 254561489 8195088 complement(2992488..2992772) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2992772 8195088 METDI3076 Methylobacterium extorquens DM4 hypothetical protein YP_003068584.1 2992488 R 661410 CDS YP_003068585.1 254561490 8192883 complement(2992859..2993524) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2993524 8192883 METDI3077 Methylobacterium extorquens DM4 hypothetical protein YP_003068585.1 2992859 R 661410 CDS YP_003068586.1 254561491 8192884 complement(2993720..2994421) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8226680, 9006018; Product type pe : putative enzyme; putative haloacid dehalogenase family hydrolase 2994421 8192884 METDI3078 Methylobacterium extorquens DM4 putative haloacid dehalogenase family hydrolase YP_003068586.1 2993720 R 661410 CDS YP_003068587.1 254561492 8192885 2994617..2995114 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2995114 8192885 METDI3079 Methylobacterium extorquens DM4 hypothetical protein YP_003068587.1 2994617 D 661410 CDS YP_003068588.1 254561493 8192886 2995295..2996005 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 12517338, 8366047; Product type e : enzyme; Ribose-5-phosphate isomerase A 2996005 rpiA 8192886 rpiA Methylobacterium extorquens DM4 Ribose-5-phosphate isomerase A YP_003068588.1 2995295 D 661410 CDS YP_003068589.1 254561494 8196011 2996047..2996643 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2996643 8196011 METDI3081 Methylobacterium extorquens DM4 hypothetical protein YP_003068589.1 2996047 D 661410 CDS YP_003068590.1 254561495 8192887 2996815..2997984 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2997984 8192887 METDI3082 Methylobacterium extorquens DM4 hypothetical protein YP_003068590.1 2996815 D 661410 CDS YP_003068591.1 254561496 8192888 2997981..2999381 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 1849605; Product type e : enzyme; glutathione reductase 2999381 gor 8192888 gor Methylobacterium extorquens DM4 glutathione reductase YP_003068591.1 2997981 D 661410 CDS YP_003068592.1 254561497 8195527 complement(2999383..3000807) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3000807 8195527 METDI3084 Methylobacterium extorquens DM4 hypothetical protein YP_003068592.1 2999383 R 661410 CDS YP_003068593.1 254561498 8192889 3001041..3001523 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3001523 8192889 METDI3085 Methylobacterium extorquens DM4 hypothetical protein YP_003068593.1 3001041 D 661410 CDS YP_003068594.1 254561499 8192890 3001609..3002040 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 15188393, 16926146, 1715407; Product type m : membrane component; osmotically inducible protein OsmC 3002040 osmC 8192890 osmC Methylobacterium extorquens DM4 osmotically inducible protein OsmC YP_003068594.1 3001609 D 661410 CDS YP_003068595.1 254561500 8195813 3002147..3003358 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3003358 8195813 METDI3087 Methylobacterium extorquens DM4 hypothetical protein YP_003068595.1 3002147 D 661410 CDS YP_003068596.1 254561501 8192891 3003358..3004815 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; Uracil-DNA glycosylase superfamily protein (DNA replication, recombination and repair) 3004815 ung 8192891 ung Methylobacterium extorquens DM4 Uracil-DNA glycosylase superfamily protein (DNA replication, recombination and repair) YP_003068596.1 3003358 D 661410 CDS YP_003068597.1 254561502 8196304 3005099..3006271 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative zinc-containing alcohol dehydrogenase 3006271 8196304 METDI3089 Methylobacterium extorquens DM4 putative zinc-containing alcohol dehydrogenase YP_003068597.1 3005099 D 661410 CDS YP_003068598.1 254561503 8192892 3006414..3006998 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3006998 8192892 METDI3090 Methylobacterium extorquens DM4 hypothetical protein YP_003068598.1 3006414 D 661410 CDS YP_003068599.1 254561504 8192893 complement(3007056..3008753) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3008753 8192893 METDI3091 Methylobacterium extorquens DM4 hypothetical protein YP_003068599.1 3007056 R 661410 CDS YP_003068600.1 254561505 8192894 complement(3008750..3009868) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3009868 8192894 METDI3092 Methylobacterium extorquens DM4 hypothetical protein YP_003068600.1 3008750 R 661410 CDS YP_003068601.1 254561506 8192895 3010048..3010710 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3010710 8192895 METDI3093 Methylobacterium extorquens DM4 hypothetical protein YP_003068601.1 3010048 D 661410 CDS YP_003068602.1 254561507 8192896 3010749..3011336 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative glutathione S-transferase 3011336 8192896 METDI3094 Methylobacterium extorquens DM4 putative glutathione S-transferase YP_003068602.1 3010749 D 661410 CDS YP_003068603.1 254561508 8192897 3011495..3011749 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3011749 8192897 METDI3095 Methylobacterium extorquens DM4 hypothetical protein YP_003068603.1 3011495 D 661410 CDS YP_003068604.1 254561509 8192898 3011923..3012915 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative catalase precursor 3012915 8192898 METDI3096 Methylobacterium extorquens DM4 putative catalase precursor YP_003068604.1 3011923 D 661410 CDS YP_003068605.1 254561510 8192899 complement(3013348..3013953) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3013953 8192899 METDI3097 Methylobacterium extorquens DM4 hypothetical protein YP_003068605.1 3013348 R 661410 CDS YP_003068606.1 254561511 8192900 complement(3013964..3014551) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; Nitroreductase family protein 3014551 8192900 METDI3098 Methylobacterium extorquens DM4 Nitroreductase family protein YP_003068606.1 3013964 R 661410 CDS YP_003068607.1 254561512 8192901 3014708..3015640 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3015640 8192901 METDI3099 Methylobacterium extorquens DM4 hypothetical protein YP_003068607.1 3014708 D 661410 CDS YP_003068608.1 254561513 8192902 3015646..3016038 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3016038 8192902 METDI3100 Methylobacterium extorquens DM4 hypothetical protein YP_003068608.1 3015646 D 661410 CDS YP_003068609.1 254561514 8192903 complement(3016245..3016376) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3016376 8192903 METDI3101 Methylobacterium extorquens DM4 hypothetical protein YP_003068609.1 3016245 R 661410 CDS YP_003068610.1 254561515 8192904 3016503..3017897 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcriptional regulator (GntR family) 3017897 8192904 METDI3102 Methylobacterium extorquens DM4 putative transcriptional regulator (GntR family) YP_003068610.1 3016503 D 661410 CDS YP_003068611.1 254561516 8192905 complement(3017928..3019955) 1 NC_012988.1 catalyzes a two-step reaction, first charging a threonine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; catalyzes the formation of threonyl-tRNA(Thr) from threonine and tRNA(Thr); threonyl-tRNA synthetase 3019955 thrS 8192905 thrS Methylobacterium extorquens DM4 threonyl-tRNA synthetase YP_003068611.1 3017928 R 661410 CDS YP_003068612.1 254561517 8196195 complement(3020121..3020873) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3020873 8196195 METDI3104 Methylobacterium extorquens DM4 hypothetical protein YP_003068612.1 3020121 R 661410 CDS YP_003068613.1 254561518 8192906 complement(3020870..3021772) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11742072; Product type pe : putative enzyme; putative kinase (mak-like) /transcriptional regulator, actin-like ATPase domain (NagC/XylR (ROK) familiy) 3021772 8192906 METDI3105 Methylobacterium extorquens DM4 putative kinase (mak-like) /transcriptional regulator, actin-like ATPase domain (NagC/XylR (ROK) familiy) YP_003068613.1 3020870 R 661410 CDS YP_003068614.1 254561519 8192907 complement(3021795..3023123) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 10482502, 4568614; Product type t : transporter; sodium:dicarboxylate symporter (DAACS family) 3023123 dctA 8192907 dctA Methylobacterium extorquens DM4 sodium:dicarboxylate symporter (DAACS family) YP_003068614.1 3021795 R 661410 CDS YP_003068615.1 254561520 8195279 3023675..3026650 1 NC_012988.1 IleRS; catalyzes the formation of isoleucyl-tRNA(Ile) from isoleucine and tRNA(Ile); since isoleucine and other amino acids such as valine are similar, there are additional editing function in this enzyme; one is involved in hydrolysis of activated valine-AMP and the other is involved in deacylation of mischarged Val-tRNA(Ile); there are two active sites, one for aminoacylation and one for editing; class-I aminoacyl-tRNA synthetase family; some organisms carry two different copies of this enzyme; isoleucyl-tRNA synthetase 3026650 ileS 8195279 ileS Methylobacterium extorquens DM4 isoleucyl-tRNA synthetase YP_003068615.1 3023675 D 661410 CDS YP_003068616.1 254561521 8195591 3026647..3027162 1 NC_012988.1 lipoprotein signal peptidase; integral membrane protein that removes signal peptides from prolipoproteins during lipoprotein biosynthesis; lipoprotein signal peptidase 3027162 lspA 8195591 lspA Methylobacterium extorquens DM4 lipoprotein signal peptidase YP_003068616.1 3026647 D 661410 CDS YP_003068617.1 254561522 8195653 3027325..3028029 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3028029 8195653 METDI3109 Methylobacterium extorquens DM4 hypothetical protein YP_003068617.1 3027325 D 661410 CDS YP_003068618.1 254561523 8192908 3028223..3029605 1 NC_012988.1 Evidence 1c : Function experimentally demonstrated in the studied genus; Product type e : enzyme; putative protease 3029605 pqqF 8192908 pqqF Methylobacterium extorquens DM4 putative protease YP_003068618.1 3028223 D 661410 CDS YP_003068619.1 254561524 8195892 3029677..3030960 1 NC_012988.1 Evidence 1c : Function experimentally demonstrated in the studied genus; Product type e : enzyme; putative protease 3030960 pqqG 8195892 pqqG Methylobacterium extorquens DM4 putative protease YP_003068619.1 3029677 D 661410 CDS YP_003068620.1 254561525 8195893 3031147..3032079 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10542173; Product type pe : putative enzyme; putative linE 3032079 8195893 METDI3112 Methylobacterium extorquens DM4 putative linE YP_003068620.1 3031147 D 661410 CDS YP_003068621.1 254561526 8192909 3032249..3033022 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 8034707, 9865948; Product type e : enzyme; ferredoxin--NADP+ reductase 3033022 fpr 8192909 fpr Methylobacterium extorquens DM4 ferredoxin--NADP+ reductase YP_003068621.1 3032249 D 661410 CDS YP_003068622.1 254561527 8195441 3033316..3033993 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 11259647; Product type e : enzyme; Dethiobiotin synthetase (Dethiobiotin synthase) (DTB synthetase) (DTBS) 3033993 bioD 8195441 bioD Methylobacterium extorquens DM4 Dethiobiotin synthetase (Dethiobiotin synthase) (DTB synthetase) (DTBS) YP_003068622.1 3033316 D 661410 CDS YP_003068623.1 254561528 8195144 complement(3034000..3034359) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3034359 8195144 METDI3115 Methylobacterium extorquens DM4 hypothetical protein YP_003068623.1 3034000 R 661410 CDS YP_003068624.1 254561529 8192910 complement(3034393..3034812) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative Response regulator receiver domain (cheY-like protein) 3034812 8192910 METDI3116 Methylobacterium extorquens DM4 putative Response regulator receiver domain (cheY-like protein) YP_003068624.1 3034393 R 661410 CDS YP_003068625.1 254561530 8192911 3035080..3035754 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3035754 8192911 METDI3117 Methylobacterium extorquens DM4 hypothetical protein YP_003068625.1 3035080 D 661410 CDS YP_003068626.1 254561531 8192912 3035772..3036779 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; WD-40 repeat family protein 3036779 8192912 METDI3118 Methylobacterium extorquens DM4 WD-40 repeat family protein YP_003068626.1 3035772 D 661410 CDS YP_003068627.1 254561532 8192913 3036790..3037050 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3037050 8192913 METDI3119 Methylobacterium extorquens DM4 hypothetical protein YP_003068627.1 3036790 D 661410 CDS YP_003068628.1 254561533 8192914 3037117..3037647 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3037647 8192914 METDI3120 Methylobacterium extorquens DM4 hypothetical protein YP_003068628.1 3037117 D 661410 CDS YP_003068629.1 254561534 8192915 3037777..3039009 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3039009 8192915 METDI3121 Methylobacterium extorquens DM4 hypothetical protein YP_003068629.1 3037777 D 661410 CDS YP_003068630.1 254561535 8192916 complement(3039014..3039454) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3039454 8192916 METDI3122 Methylobacterium extorquens DM4 hypothetical protein YP_003068630.1 3039014 R 661410 CDS YP_003068631.1 254561536 8192917 complement(3039451..3040197) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative Pyrimidine 5-nucleotidase (HAD-superfamily hydrolase) 3040197 8192917 METDI3123 Methylobacterium extorquens DM4 putative Pyrimidine 5-nucleotidase (HAD-superfamily hydrolase) YP_003068631.1 3039451 R 661410 CDS YP_003068632.1 254561537 8192918 complement(3040285..3041181) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type e : enzyme; acetylglutamate kinase 3041181 argB 8192918 argB Methylobacterium extorquens DM4 acetylglutamate kinase YP_003068632.1 3040285 R 661410 CDS YP_003068633.1 254561538 8195083 3041581..3041805 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 3041805 8195083 METDI3125 Methylobacterium extorquens DM4 hypothetical protein YP_003068633.1 3041581 D 661410 CDS YP_003068634.1 254561539 8192919 complement(3041827..3042603) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; MOSC (sulfur-carrier) domain protein 3042603 8192919 METDI3126 Methylobacterium extorquens DM4 MOSC (sulfur-carrier) domain protein YP_003068634.1 3041827 R 661410 CDS YP_003068635.1 254561540 8192920 3042740..3043534 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; MOSC (sulfur-carrier) domain protein 3043534 8192920 METDI3127 Methylobacterium extorquens DM4 MOSC (sulfur-carrier) domain protein YP_003068635.1 3042740 D 661410 CDS YP_003068636.1 254561541 8192921 3043763..3046387 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type f : factor; protein disaggregation chaperone 3046387 clpB 8192921 clpB Methylobacterium extorquens DM4 protein disaggregation chaperone YP_003068636.1 3043763 D 661410 CDS YP_003068637.1 254561542 8195171 3046565..3047239 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; Metallophosphoesterase 3047239 8195171 METDI3129 Methylobacterium extorquens DM4 Metallophosphoesterase YP_003068637.1 3046565 D 661410 CDS YP_003068638.1 254561543 8192922 3047367..3048806 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type t : transporter; short-chain fatty acid transporter (scFAT family) 3048806 atoE 8192922 atoE Methylobacterium extorquens DM4 short-chain fatty acid transporter (scFAT family) YP_003068638.1 3047367 D 661410 CDS YP_003068639.1 254561544 8195115 complement(3048814..3049032) 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 3049032 8195115 METDI3131 Methylobacterium extorquens DM4 hypothetical protein YP_003068639.1 3048814 R 661410 CDS YP_003068640.1 254561545 8192923 complement(3049067..3049438) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3049438 8192923 METDI3132 Methylobacterium extorquens DM4 hypothetical protein YP_003068640.1 3049067 R 661410 CDS YP_003068641.1 254561546 8192924 complement(3049435..3050094) 1 NC_012988.1 binds guanine nucleotides; in Escherichia coli depletion results in defective cell division and filamentation; in Bacillus subtilis this gene is essential; ribosome biogenesis GTP-binding protein YsxC 3050094 engB 8192924 engB Methylobacterium extorquens DM4 ribosome biogenesis GTP-binding protein YsxC YP_003068641.1 3049435 R 661410 CDS YP_003068642.1 254561547 8192925 complement(3050342..3052255) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 17922846; Product type m : membrane component; transmembrane protein, OxaA-like, preprotein translocase component 3052255 oxaA 8192925 oxaA Methylobacterium extorquens DM4 transmembrane protein, OxaA-like, preprotein translocase component YP_003068642.1 3050342 R 661410 CDS YP_003068643.1 254561548 8195815 complement(3052185..3052682) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; ribonuclease P protein component (RNaseP protein, RNase P protein, protein C5) 3052682 rnpA 8195815 rnpA Methylobacterium extorquens DM4 ribonuclease P protein component (RNaseP protein, RNase P protein, protein C5) YP_003068643.1 3052185 R 661410 CDS YP_003068644.1 254561549 8196006 3053017..3053241 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3053241 8196006 METDI3136 Methylobacterium extorquens DM4 hypothetical protein YP_003068644.1 3053017 D 661410 CDS YP_003068645.1 254561550 8192926 3053562..3054095 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcriptional regulator, AraC family 3054095 8192926 METDI3137 Methylobacterium extorquens DM4 putative transcriptional regulator, AraC family YP_003068645.1 3053562 D 661410 CDS YP_003068646.1 254561551 8192927 complement(3054429..3054683) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type s : structure; 50S ribosomal protein L31 3054683 rpmE 8192927 rpmE Methylobacterium extorquens DM4 50S ribosomal protein L31 YP_003068646.1 3054429 R 661410 CDS YP_003068647.1 254561552 8196039 3054976..3056835 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative ABC transporter related, fused ATPase and transmembrane permease domains 3056835 8196039 METDI3139 Methylobacterium extorquens DM4 putative ABC transporter related, fused ATPase and transmembrane permease domains YP_003068647.1 3054976 D 661410 CDS YP_003068648.1 254561553 8192928 3056969..3057976 1 NC_012988.1 catalyzes the formation of pyruvate from D-cysteine; D-cysteine desulfhydrase 3057976 dcyD 8192928 dcyD Methylobacterium extorquens DM4 D-cysteine desulfhydrase YP_003068648.1 3056969 D 661410 CDS YP_003068649.1 254561554 8195282 complement(3058016..3059029) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type s : structure; flagellar motor protein MotB 3059029 motB 8195282 motB Methylobacterium extorquens DM4 flagellar motor protein MotB YP_003068649.1 3058016 R 661410 CDS YP_003068650.1 254561555 8195718 complement(3059030..3060025) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3060025 8195718 METDI3142 Methylobacterium extorquens DM4 hypothetical protein YP_003068650.1 3059030 R 661410 CDS YP_003068651.1 254561556 8192929 complement(3060187..3061008) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3061008 8192929 METDI3143 Methylobacterium extorquens DM4 hypothetical protein YP_003068651.1 3060187 R 661410 CDS YP_003068652.1 254561557 8192930 complement(3061074..3061664) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative ligase (ygfA) 3061664 8192930 METDI3144 Methylobacterium extorquens DM4 putative ligase (ygfA) YP_003068652.1 3061074 R 661410 CDS YP_003068653.1 254561558 8192931 complement(3061912..3062283) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3062283 8192931 METDI3145 Methylobacterium extorquens DM4 hypothetical protein YP_003068653.1 3061912 R 661410 CDS YP_003068654.1 254561559 8192932 complement(3062307..3062627) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3062627 8192932 METDI3146 Methylobacterium extorquens DM4 hypothetical protein YP_003068654.1 3062307 R 661410 CDS YP_003068655.1 254561560 8192933 3063090..3064097 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 10799476, 7751290; Product type e : enzyme; Glyceraldehyde-3-phosphate dehydrogenase 3064097 gapA 8192933 gapA Methylobacterium extorquens DM4 Glyceraldehyde-3-phosphate dehydrogenase YP_003068655.1 3063090 D 661410 CDS YP_003068656.1 254561561 8195467 3064292..3064798 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3064798 8195467 METDI3148 Methylobacterium extorquens DM4 hypothetical protein YP_003068656.1 3064292 D 661410 CDS YP_003068657.1 254561562 8192934 3064814..3066016 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 1433299; Product type e : enzyme; phosphoglycerate kinase 3066016 pgk 8192934 pgk Methylobacterium extorquens DM4 phosphoglycerate kinase YP_003068657.1 3064814 D 661410 CDS YP_003068658.1 254561563 8195849 3066169..3067236 1 NC_012988.1 class II aldolase; catalyzes the reversible aldol condensation of dihydroxyacetonephosphate and glyceraldehyde 3-phosphate in the Calvin cycle, glycolysis and gluconeogenesis; fructose-1,6-bisphosphate aldolase 3067236 cbbA 8195849 cbbA Methylobacterium extorquens DM4 fructose-1,6-bisphosphate aldolase YP_003068658.1 3066169 D 661410 CDS YP_003068659.1 254561564 8195149 3067243..3067911 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative thiamine-phosphate pyrophosphorylase (TMP pyrophosphorylase) (TMP-PPase) (thiamine-phosphate synthase) 3067911 8195149 METDI3151 Methylobacterium extorquens DM4 putative thiamine-phosphate pyrophosphorylase (TMP pyrophosphorylase) (TMP-PPase) (thiamine-phosphate synthase) YP_003068659.1 3067243 D 661410 CDS YP_003068660.1 254561565 8192935 3067908..3069056 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Sel1-like repeats containing protein 3069056 8192935 METDI3152 Methylobacterium extorquens DM4 Sel1-like repeats containing protein YP_003068660.1 3067908 D 661410 CDS YP_003068661.1 254561566 8192936 3069286..3070695 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative amino acid permease 3070695 8192936 METDI3153 Methylobacterium extorquens DM4 putative amino acid permease YP_003068661.1 3069286 D 661410 CDS YP_003068662.1 254561567 8192937 complement(3070705..3072228) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative carbohydrate kinase 3072228 8192937 METDI3154 Methylobacterium extorquens DM4 putative carbohydrate kinase YP_003068662.1 3070705 R 661410 CDS YP_003068663.1 254561568 8192938 3072413..3072751 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type r : regulator; regulatory protein (P-II) for nitrogen assimilation by glutamine synthetase (ATase) 3072751 glnB 8192938 glnB Methylobacterium extorquens DM4 regulatory protein (P-II) for nitrogen assimilation by glutamine synthetase (ATase) YP_003068663.1 3072413 D 661410 CDS YP_003068664.1 254561569 8195498 3072838..3073767 1 NC_012988.1 catalyzes the formation of glutamate from glutamine; glutaminase 3073767 glsA 8195498 glsA Methylobacterium extorquens DM4 glutaminase YP_003068664.1 3072838 D 661410 CDS YP_003068665.1 254561570 8195510 complement(3074008..3075054) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 1355107; Product type e : enzyme; glutamine synthetase II 3075054 glnII 8195510 glnII Methylobacterium extorquens DM4 glutamine synthetase II YP_003068665.1 3074008 R 661410 CDS YP_003068666.1 254561571 8195503 3075630..3077039 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 2882477; Product type e : enzyme; glutamine synthetase, type I 3077039 glnA 8195503 glnA Methylobacterium extorquens DM4 glutamine synthetase, type I YP_003068666.1 3075630 D 661410 CDS YP_003068667.1 254561572 8195497 3077172..3077750 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; NADPH-dependent FMN reductase 3077750 8195497 METDI3159 Methylobacterium extorquens DM4 NADPH-dependent FMN reductase YP_003068667.1 3077172 D 661410 CDS YP_003068668.1 254561573 8192939 3077895..3078233 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3078233 8192939 METDI3160 Methylobacterium extorquens DM4 hypothetical protein YP_003068668.1 3077895 D 661410 CDS YP_003068669.1 254561574 8192940 3078167..3078280 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3078280 8192940 METDI3161 Methylobacterium extorquens DM4 hypothetical protein YP_003068669.1 3078167 D 661410 CDS YP_003068670.1 254561575 8192941 3078392..3080758 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; ribonuclease R 3080758 RNR 8192941 RNR Methylobacterium extorquens DM4 ribonuclease R YP_003068670.1 3078392 D 661410 CDS YP_003068671.1 254561576 8196007 3080782..3081279 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3081279 8196007 METDI3163 Methylobacterium extorquens DM4 hypothetical protein YP_003068671.1 3080782 D 661410 CDS YP_003068672.1 254561577 8192942 3081320..3082003 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative NUDIX hydrolase 3082003 8192942 METDI3164 Methylobacterium extorquens DM4 putative NUDIX hydrolase YP_003068672.1 3081320 D 661410 CDS YP_003068673.1 254561578 8192943 3082125..3084089 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type rc : receptor; methyl-accepting chemotaxis receptor/sensory transducer with PAS domain 3084089 8192943 METDI3165 Methylobacterium extorquens DM4 methyl-accepting chemotaxis receptor/sensory transducer with PAS domain YP_003068673.1 3082125 D 661410 CDS YP_003068674.1 254561579 8192944 complement(3084149..3085018) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative epimerase with NAD(P)-binding Rossmann-fold domain (yeeZ-like) 3085018 8192944 METDI3166 Methylobacterium extorquens DM4 putative epimerase with NAD(P)-binding Rossmann-fold domain (yeeZ-like) YP_003068674.1 3084149 R 661410 CDS YP_003068675.1 254561580 8192945 complement(3085025..3086329) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier; putative iron-sulfur cluster binding protein 3086329 8192945 METDI3167 Methylobacterium extorquens DM4 putative iron-sulfur cluster binding protein YP_003068675.1 3085025 R 661410 CDS YP_003068676.1 254561581 8192946 complement(3086200..3086892) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative glutathione S-transferase 3086892 8192946 METDI3168 Methylobacterium extorquens DM4 putative glutathione S-transferase YP_003068676.1 3086200 R 661410 CDS YP_003068677.1 254561582 8192947 3087120..3087971 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 11743193, 11743194; Product type e : enzyme; Undecaprenyl-diphosphatase (Undecaprenyl pyrophosphate phosphatase) (Bacitracin resistance protein) 3087971 bacA 8192947 bacA Methylobacterium extorquens DM4 Undecaprenyl-diphosphatase (Undecaprenyl pyrophosphate phosphatase) (Bacitracin resistance protein) YP_003068677.1 3087120 D 661410 CDS YP_003068678.1 254561583 8195124 3088120..3089937 1 NC_012988.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14734568; Product type e : enzyme; methylmalonyl-CoA beta subunit 3089937 mcmB 8195124 mcmB Methylobacterium extorquens DM4 methylmalonyl-CoA beta subunit YP_003068678.1 3088120 D 661410 CDS YP_003068679.1 254561584 8195669 3090045..3090437 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3090437 8195669 METDI3171 Methylobacterium extorquens DM4 hypothetical protein YP_003068679.1 3090045 D 661410 CDS YP_003068680.1 254561585 8192948 3090624..3091079 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3091079 8192948 METDI3172 Methylobacterium extorquens DM4 hypothetical protein YP_003068680.1 3090624 D 661410 CDS YP_003068681.1 254561586 8192949 complement(3091102..3091545) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3091545 8192949 METDI3173 Methylobacterium extorquens DM4 hypothetical protein YP_003068681.1 3091102 R 661410 CDS YP_003068682.1 254561587 8192950 3091731..3092282 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 1710759; Product type e : enzyme; dTDP-4-dehydrorhamnose 3,5-epimerase 3092282 rfbC 8192950 rfbC Methylobacterium extorquens DM4 dTDP-4-dehydrorhamnose 3,5-epimerase YP_003068682.1 3091731 D 661410 CDS YP_003068683.1 254561588 8195983 3092416..3093474 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 7559340; Product type e : enzyme; dTDP-glucose 4,6-dehydratase 3093474 rffG 8195983 rffG Methylobacterium extorquens DM4 dTDP-glucose 4,6-dehydratase YP_003068683.1 3092416 D 661410 CDS YP_003068684.1 254561589 8195987 3093477..3094367 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; dTDP-4-dehydrorhamnose reductase 3094367 rfbD 8195987 rfbD Methylobacterium extorquens DM4 dTDP-4-dehydrorhamnose reductase YP_003068684.1 3093477 D 661410 CDS YP_003068685.1 254561590 8195984 3094384..3095274 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 7559340; Product type e : enzyme; Glucose-1-phosphate thymidylyltransferase 3095274 rffH 8195984 rffH Methylobacterium extorquens DM4 Glucose-1-phosphate thymidylyltransferase YP_003068685.1 3094384 D 661410 CDS YP_003068686.1 254561591 8195988 complement(3095407..3096066) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3096066 8195988 METDI3178 Methylobacterium extorquens DM4 hypothetical protein YP_003068686.1 3095407 R 661410 CDS YP_003068687.1 254561592 8192951 complement(3096136..3097017) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3097017 8192951 METDI3179 Methylobacterium extorquens DM4 hypothetical protein YP_003068687.1 3096136 R 661410 CDS YP_003068688.1 254561593 8192952 complement(3097031..3099067) 1 NC_012988.1 functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; in some organisms, there are paralogous proteins that have been found to be nonessential but do function in secretion of a subset of exported proteins; preprotein translocase subunit SecA 3099067 secA 8192952 secA Methylobacterium extorquens DM4 preprotein translocase subunit SecA YP_003068688.1 3097031 R 661410 CDS YP_003068689.1 254561594 8192953 complement(3099060..3100154) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3100154 8192953 METDI3181 Methylobacterium extorquens DM4 hypothetical protein YP_003068689.1 3099060 R 661410 CDS YP_003068690.1 254561595 8192954 3100250..3100999 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3100999 8192954 METDI3182 Methylobacterium extorquens DM4 hypothetical protein YP_003068690.1 3100250 D 661410 CDS YP_003068691.1 254561596 8192955 complement(3101107..3102546) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative multicopper oxidase 3102546 8192955 METDI3183 Methylobacterium extorquens DM4 putative multicopper oxidase YP_003068691.1 3101107 R 661410 CDS YP_003068692.1 254561597 8196239 3102927..3104363 1 NC_012988.1 Tig; RopA; peptidyl-prolyl cis/trans isomerase; promotes folding of newly synthesized proteins; binds ribosomal 50S subunit; forms a homodimer; trigger factor 3104363 tig 8196239 tig Methylobacterium extorquens DM4 trigger factor YP_003068692.1 3102927 D 661410 CDS YP_003068693.1 254561598 8196197 3104495..3105121 1 NC_012988.1 hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates; ATP-dependent Clp protease proteolytic subunit 3105121 clpP 8196197 clpP Methylobacterium extorquens DM4 ATP-dependent Clp protease proteolytic subunit YP_003068693.1 3104495 D 661410 CDS YP_003068694.1 254561599 8195172 3105373..3106644 1 NC_012988.1 binds and unfolds substrates as part of the ClpXP protease; ATP-dependent protease ATP-binding subunit ClpX 3106644 clpX 8195172 clpX Methylobacterium extorquens DM4 ATP-dependent protease ATP-binding subunit ClpX YP_003068694.1 3105373 D 661410 CDS YP_003068695.1 254561600 8195174 3106912..3109332 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 10877760, 12123452, 14764100; Product type e : enzyme; ATP-dependent protease La (Lon) 3109332 lon 8195174 lon Methylobacterium extorquens DM4 ATP-dependent protease La (Lon) YP_003068695.1 3106912 D 661410 CDS YP_003068696.1 254561601 8196267 complement(3109923..3110159) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3110159 8196267 METDI3188 Methylobacterium extorquens DM4 hypothetical protein YP_003068696.1 3109923 R 661410 CDS YP_003068697.1 254561602 8192957 3110487..3111725 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative Glycosyl transferase, group 1 3111725 8192957 METDI3189 Methylobacterium extorquens DM4 putative Glycosyl transferase, group 1 YP_003068697.1 3110487 D 661410 CDS YP_003068698.1 254561603 8192958 complement(3111737..3112684) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3112684 8192958 METDI3190 Methylobacterium extorquens DM4 hypothetical protein YP_003068698.1 3111737 R 661410 CDS YP_003068699.1 254561604 8192959 complement(3112681..3113706) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3113706 8192959 METDI3191 Methylobacterium extorquens DM4 hypothetical protein YP_003068699.1 3112681 R 661410 CDS YP_003068700.1 254561605 8192960 complement(3113709..3114464) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3114464 8192960 METDI3192 Methylobacterium extorquens DM4 hypothetical protein YP_003068700.1 3113709 R 661410 CDS YP_003068701.1 254561606 8192961 complement(3114741..3115337) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3115337 8192961 METDI3193 Methylobacterium extorquens DM4 hypothetical protein YP_003068701.1 3114741 R 661410 CDS YP_003068702.1 254561607 8192962 3115510..3117525 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative oligopeptide transporter, OPT superfamily 3117525 8192962 METDI3194 Methylobacterium extorquens DM4 putative oligopeptide transporter, OPT superfamily YP_003068702.1 3115510 D 661410 CDS YP_003068703.1 254561608 8192963 3117594..3118388 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type t : transporter; ABC-2 transporter, permease 3118388 8192963 METDI3195 Methylobacterium extorquens DM4 ABC-2 transporter, permease YP_003068703.1 3117594 D 661410 CDS YP_003068704.1 254561609 8196214 complement(3118978..3119679) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3119679 8196214 METDI3196 Methylobacterium extorquens DM4 hypothetical protein YP_003068704.1 3118978 R 661410 CDS YP_003068705.1 254561610 8192965 3119915..3121108 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; Ribonuclease BN family protein 3121108 8192965 METDI3197 Methylobacterium extorquens DM4 Ribonuclease BN family protein YP_003068705.1 3119915 D 661410 CDS YP_003068706.1 254561611 8192966 complement(3121456..3121848) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3121848 8192966 METDI3198 Methylobacterium extorquens DM4 hypothetical protein YP_003068706.1 3121456 R 661410 CDS YP_003068707.1 254561612 8192967 3122353..3125496 1 NC_012988.1 Evidence 1a : Function experimentally demonstrated in the studied strain; PubMedId : 10986246; Product type e : enzyme; DNA polymerase I 3125496 polA 8192967 polA Methylobacterium extorquens DM4 DNA polymerase I YP_003068707.1 3122353 D 661410 CDS YP_003068708.1 254561613 8195874 complement(3126542..3127204) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 20075121, 6246346, 8206931, 8990280, 9388217, 97144513; Product type e : enzyme; Endonuclease V (Deoxyinosine 3'endonuclease) (Deoxyribonuclease V) (DNase V) 3127204 nfi 8195874 nfi Methylobacterium extorquens DM4 Endonuclease V (Deoxyinosine 3'endonuclease) (Deoxyribonuclease V) (DNase V) YP_003068708.1 3126542 R 661410 CDS YP_003068709.1 254561614 8195776 complement(3127218..3128315) 1 NC_012988.1 translation-associated GTPase; the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3); fluorescence spectroscopy revealed nucleic acid binding; the yeast protein YBR025c interacts with the translation elongation factor eEF1; GTP-dependent nucleic acid-binding protein EngD 3128315 ychF 8195776 ychF Methylobacterium extorquens DM4 GTP-dependent nucleic acid-binding protein EngD YP_003068709.1 3127218 R 661410 CDS YP_003068710.1 254561615 8196356 complement(3128395..3129027) 1 NC_012988.1 Enables the recycling of peptidyl-tRNAs produced at termination of translation; peptidyl-tRNA hydrolase 3129027 pth 8196356 pth Methylobacterium extorquens DM4 peptidyl-tRNA hydrolase YP_003068710.1 3128395 R 661410 CDS YP_003068711.1 254561616 8195915 complement(3129129..3129815) 1 NC_012988.1 the Ctc family of proteins consists of two types, one that contains the N-terminal ribosomal protein L25 domain only which in Escherichia coli binds the 5S rRNA while a subset of proteins contain a C-terminal extension that is involved in the stress response; 50S ribosomal protein L25/general stress protein Ctc 3129815 rplY 8195915 rplY Methylobacterium extorquens DM4 50S ribosomal protein L25/general stress protein Ctc YP_003068711.1 3129129 R 661410 CDS YP_003068712.1 254561617 8196034 complement(3130096..3130578) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3130578 8196034 METDI3204 Methylobacterium extorquens DM4 hypothetical protein YP_003068712.1 3130096 R 661410 CDS YP_003068713.1 254561618 8192968 3130931..3131137 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 10880436; Product type f : factor; Flp/Fap pilin component 3131137 8192968 METDI3205 Methylobacterium extorquens DM4 Flp/Fap pilin component YP_003068713.1 3130931 D 661410 CDS YP_003068714.1 254561619 8192969 3131336..3131854 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; type IV prepilin peptidase, cpaA 3131854 cpaA 8192969 cpaA Methylobacterium extorquens DM4 type IV prepilin peptidase, cpaA YP_003068714.1 3131336 D 661410 CDS YP_003068715.1 254561620 8195209 3132047..3132832 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type f : factor; pilus assembly protein cpaB 3132832 cpaB 8195209 cpaB Methylobacterium extorquens DM4 pilus assembly protein cpaB YP_003068715.1 3132047 D 661410 CDS YP_003068716.1 254561621 8195210 3132844..3134352 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; putative pilus assembly protein; putative precursor 3134352 8195210 METDI3208 Methylobacterium extorquens DM4 putative pilus assembly protein; putative precursor YP_003068716.1 3132844 D 661410 CDS YP_003068717.1 254561622 8192970 3134378..3135124 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type s : structure; pilus assembly protein cpaD 3135124 cpaD 8192970 cpaD Methylobacterium extorquens DM4 pilus assembly protein cpaD YP_003068717.1 3134378 D 661410 CDS YP_003068718.1 254561623 8195211 3135210..3136454 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type s : structure; pilus assembly protein cpaE 3136454 cpaE 8195211 cpaE Methylobacterium extorquens DM4 pilus assembly protein cpaE YP_003068718.1 3135210 D 661410 CDS YP_003068719.1 254561624 8195212 3136502..3137950 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; secretory protein kinase, cpaF 3137950 cpaF 8195212 cpaF Methylobacterium extorquens DM4 secretory protein kinase, cpaF YP_003068719.1 3136502 D 661410 CDS YP_003068720.1 254561625 8195213 3137947..3138918 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type t : transporter; Pilus assembly protein, type II secretion protein 3138918 8195213 METDI3212 Methylobacterium extorquens DM4 Pilus assembly protein, type II secretion protein YP_003068720.1 3137947 D 661410 CDS YP_003068721.1 254561626 8192971 3138967..3139938 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3139938 8192971 METDI3213 Methylobacterium extorquens DM4 hypothetical protein YP_003068721.1 3138967 D 661410 CDS YP_003068722.1 254561627 8192972 3140039..3141037 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3141037 8192972 METDI3214 Methylobacterium extorquens DM4 hypothetical protein YP_003068722.1 3140039 D 661410 CDS YP_003068723.1 254561628 8192973 3141034..3142296 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative MFS transporter membrane protein 3142296 8192973 METDI3215 Methylobacterium extorquens DM4 putative MFS transporter membrane protein YP_003068723.1 3141034 D 661410 CDS YP_003068724.1 254561629 8192974 3142438..3142863 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; organic hydroperoxide resistance protein 3142863 ohr 8192974 ohr Methylobacterium extorquens DM4 organic hydroperoxide resistance protein YP_003068724.1 3142438 D 661410 CDS YP_003068725.1 254561630 8195804 complement(3143013..3143594) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; CoA Binding Domain protein 3143594 8195804 METDI3217 Methylobacterium extorquens DM4 CoA Binding Domain protein YP_003068725.1 3143013 R 661410 CDS YP_003068726.1 254561631 8192975 3143621..3144052 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3144052 8192975 METDI3218 Methylobacterium extorquens DM4 hypothetical protein YP_003068726.1 3143621 D 661410 CDS YP_003068727.1 254561632 8192976 complement(3144108..3145427) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type t : transporter; Major Facilitator Superfamily (MFS) transporter 3145427 8192976 METDI3219 Methylobacterium extorquens DM4 Major Facilitator Superfamily (MFS) transporter YP_003068727.1 3144108 R 661410 CDS YP_003068728.1 254561633 8192977 3145827..3147323 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative diguanylate cyclase with GGDEF motif; putative membrane protein 3147323 8192977 METDI3220 Methylobacterium extorquens DM4 putative diguanylate cyclase with GGDEF motif; putative membrane protein YP_003068728.1 3145827 D 661410 CDS YP_003068729.1 254561634 8192978 complement(3147396..3147815) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3147815 8192978 METDI3221 Methylobacterium extorquens DM4 hypothetical protein YP_003068729.1 3147396 R 661410 CDS YP_003068730.1 254561635 8192979 complement(3147945..3148856) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3148856 8192979 METDI3222 Methylobacterium extorquens DM4 hypothetical protein YP_003068730.1 3147945 R 661410 CDS YP_003068731.1 254561636 8192980 complement(3148904..3149236) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3149236 8192980 METDI3223 Methylobacterium extorquens DM4 hypothetical protein YP_003068731.1 3148904 R 661410 CDS YP_003068732.1 254561637 8192981 3149554..3149919 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3149919 8192981 METDI3224 Methylobacterium extorquens DM4 hypothetical protein YP_003068732.1 3149554 D 661410 CDS YP_003068733.1 254561638 8192982 3150029..3150658 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; 3'-5' exonuclease 3150658 8192982 METDI3225 Methylobacterium extorquens DM4 3'-5' exonuclease YP_003068733.1 3150029 D 661410 CDS YP_003068734.1 254561639 8192983 3150929..3151687 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3151687 8192983 METDI3226 Methylobacterium extorquens DM4 hypothetical protein YP_003068734.1 3150929 D 661410 CDS YP_003068735.1 254561640 8192984 3151684..3152424 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3152424 8192984 METDI3227 Methylobacterium extorquens DM4 hypothetical protein YP_003068735.1 3151684 D 661410 CDS YP_003068736.1 254561641 8192985 3152442..3153311 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 17056748, 7876255, 9298646; Product type pt : putative transporter; putative ABC transporter, ATPase 3153311 8192985 METDI3228 Methylobacterium extorquens DM4 putative ABC transporter, ATPase YP_003068736.1 3152442 D 661410 CDS YP_003068737.1 254561642 8192986 3153875..3155422 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 12597275, 1991712; Product type f : factor; sigma N (sigma 54) factor of RNA polymerase 3155422 rpoN 8192986 rpoN Methylobacterium extorquens DM4 sigma N (sigma 54) factor of RNA polymerase YP_003068737.1 3153875 D 661410 CDS YP_003068738.1 254561643 8196050 3155536..3156144 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 1991712, 7876255, 8025669; Product type f : factor; ribosomal subunit interface protein, sigma 54 (RpoN) modulation protein 3156144 8196050 METDI3230 Methylobacterium extorquens DM4 ribosomal subunit interface protein, sigma 54 (RpoN) modulation protein YP_003068738.1 3155536 D 661410 CDS YP_003068739.1 254561644 8192987 3156344..3156811 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type t : transporter; sugar-specific enzyme IIA component of PTS 3156811 ptsN 8192987 ptsN Methylobacterium extorquens DM4 sugar-specific enzyme IIA component of PTS YP_003068739.1 3156344 D 661410 CDS YP_003068740.1 254561645 8195917 3156813..3157142 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3157142 8195917 METDI3232 Methylobacterium extorquens DM4 hypothetical protein YP_003068740.1 3156813 D 661410 CDS YP_003068741.1 254561646 8192988 3157278..3158291 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 7892204; Product type pe : putative enzyme; Mg chelatase subunit Bchl, participate to introduce Mg in bacteriochlorophyl with BchH and BchD 3158291 bchI 8192988 bchI Methylobacterium extorquens DM4 Mg chelatase subunit Bchl, participate to introduce Mg in bacteriochlorophyl with BchH and BchD YP_003068741.1 3157278 D 661410 CDS YP_003068742.1 254561647 8195132 complement(3158315..3158953) 1 NC_012988.1 catalyzes the interconversion of 2-phosphoglycerate to 3-phosphoglycerate; phosphoglyceromutase 3158953 gpmA 8195132 gpmA Methylobacterium extorquens DM4 phosphoglyceromutase YP_003068742.1 3158315 R 661410 CDS YP_003068743.1 254561648 8195529 complement(3159090..3159893) 1 NC_012988.1 catalyzes the reduction of 2,3-dihydrodipicolinate to 2,3,4,5-tetrahydrodipicolinate in lysine and diaminopimelate biosynthesis; dihydrodipicolinate reductase 3159893 dapB 8195529 dapB Methylobacterium extorquens DM4 dihydrodipicolinate reductase YP_003068743.1 3159090 R 661410 CDS YP_003068744.1 254561649 8195271 complement(3159968..3160663) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative multiple antibiotic resistance protein, MarC family transport protein 3160663 8195271 METDI3236 Methylobacterium extorquens DM4 putative multiple antibiotic resistance protein, MarC family transport protein YP_003068744.1 3159968 R 661410 CDS YP_003068745.1 254561650 8192989 complement(3160700..3161452) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3161452 8192989 METDI3237 Methylobacterium extorquens DM4 hypothetical protein YP_003068745.1 3160700 R 661410 CDS YP_003068746.1 254561651 8192990 3161666..3162445 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative hydroxyacylglutathione hydrolase (gloB-like) with metallo-hydrolase/oxidoreductase domain 3162445 8192990 METDI3238 Methylobacterium extorquens DM4 putative hydroxyacylglutathione hydrolase (gloB-like) with metallo-hydrolase/oxidoreductase domain YP_003068746.1 3161666 D 661410 CDS YP_003068747.1 254561652 8192991 3162706..3162858 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3162858 8192991 METDI3239 Methylobacterium extorquens DM4 hypothetical protein YP_003068747.1 3162706 D 661410 CDS YP_003068748.1 254561653 8192992 3162855..3163841 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 10361305, 10635320, 11832, 20209354, 94006566, 94100681, 94222031, 9632255; Product type e : enzyme; Tyrosine recombinase xerD 3163841 xerD 8192992 xerD Methylobacterium extorquens DM4 Tyrosine recombinase xerD YP_003068748.1 3162855 D 661410 CDS YP_003068749.1 254561654 8196338 3164012..3165229 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; diguanylate cyclase precursor with GGDEF motif; putative membrane protein 3165229 8196338 METDI3241 Methylobacterium extorquens DM4 diguanylate cyclase precursor with GGDEF motif; putative membrane protein YP_003068749.1 3164012 D 661410 CDS YP_003068750.1 254561655 8192993 3165363..3167594 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative Glycoside hydrolase, family 3, N-terminal and C-terminal domain (bglX-like) 3167594 8192993 METDI3242 Methylobacterium extorquens DM4 putative Glycoside hydrolase, family 3, N-terminal and C-terminal domain (bglX-like) YP_003068750.1 3165363 D 661410 CDS YP_003068751.1 254561656 8192994 complement(3167601..3168803) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative oligopeptide transporter subunit ; permease component of ABC superfamily transporter 3168803 yejE 8192994 yejE Methylobacterium extorquens DM4 putative oligopeptide transporter subunit ; permease component of ABC superfamily transporter YP_003068751.1 3167601 R 661410 CDS YP_003068752.1 254561657 8196361 complement(3168841..3169365) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3169365 8196361 METDI3244 Methylobacterium extorquens DM4 hypothetical protein YP_003068752.1 3168841 R 661410 CDS YP_003068753.1 254561658 8192995 complement(3169362..3170546) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; hypothetical protein 3170546 8192995 METDI3245 Methylobacterium extorquens DM4 hypothetical protein YP_003068753.1 3169362 R 661410 CDS YP_003068754.1 254561659 8192996 complement(3170543..3170893) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3170893 8192996 METDI3246 Methylobacterium extorquens DM4 hypothetical protein YP_003068754.1 3170543 R 661410 CDS YP_003068755.1 254561660 8192997 3170984..3171157 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3171157 8192997 METDI3247 Methylobacterium extorquens DM4 hypothetical protein YP_003068755.1 3170984 D 661410 CDS YP_003068756.1 254561661 8192998 3171315..3172703 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 12107133, 12107134, 15793131; Product type t : transporter; multidrug efflux protein, subunit A; RND efflux transporter, membrane fusion protein subunit 3172703 8192998 METDI3248 Methylobacterium extorquens DM4 multidrug efflux protein, subunit A; RND efflux transporter, membrane fusion protein subunit YP_003068756.1 3171315 D 661410 CDS YP_003068757.1 254561662 8192999 3172716..3175853 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 12107133, 12107134; Product type t : transporter; multidrug efflux protein, subunit B; RND efflux transporter 3175853 8192999 METDI3249 Methylobacterium extorquens DM4 multidrug efflux protein, subunit B; RND efflux transporter YP_003068757.1 3172716 D 661410 CDS YP_003068758.1 254561663 8193000 3176380..3179694 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 12107133, 12107134; Product type t : transporter; multidrug efflux system, subunit C; RND efflux exporter 3179694 8193000 METDI3251 Methylobacterium extorquens DM4 multidrug efflux system, subunit C; RND efflux exporter YP_003068758.1 3176380 D 661410 CDS YP_003068759.1 254561664 8193001 3179768..3181255 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative outer membrane lipoprotein precursor 3181255 8193001 METDI3252 Methylobacterium extorquens DM4 putative outer membrane lipoprotein precursor YP_003068759.1 3179768 D 661410 CDS YP_003068760.1 254561665 8193002 3181356..3182864 1 NC_012988.1 catalyzes the formation of D-glucono-1,5-lactone 6-phosphate from D-glucose 6-phosphate; glucose-6-phosphate 1-dehydrogenase 3182864 zwf 8193002 zwf Methylobacterium extorquens DM4 glucose-6-phosphate 1-dehydrogenase YP_003068760.1 3181356 D 661410 CDS YP_003068761.1 254561666 8196383 complement(3182975..3184084) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 9003442; Product type e : enzyme; 3-isopropylmalate dehydrogenase 3184084 leuB 8196383 leuB Methylobacterium extorquens DM4 3-isopropylmalate dehydrogenase YP_003068761.1 3182975 R 661410 CDS YP_003068762.1 254561667 8195629 complement(3184192..3184509) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3184509 8195629 METDI3255 Methylobacterium extorquens DM4 hypothetical protein YP_003068762.1 3184192 R 661410 CDS YP_003068763.1 254561668 8193003 3184675..3186291 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3186291 8193003 METDI3256 Methylobacterium extorquens DM4 hypothetical protein YP_003068763.1 3184675 D 661410 CDS YP_003068764.1 254561669 8193004 3186451..3188139 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type e : enzyme; putative decarboxylase, Thiamine pyrophosphate-requiring 3188139 8193004 METDI3257 Methylobacterium extorquens DM4 putative decarboxylase, Thiamine pyrophosphate-requiring YP_003068764.1 3186451 D 661410 CDS YP_003068765.1 254561670 8193005 3188160..3188591 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3188591 8193005 METDI3258 Methylobacterium extorquens DM4 hypothetical protein YP_003068765.1 3188160 D 661410 CDS YP_003068766.1 254561671 8193006 complement(3188769..3189731) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; geranyltranstransferase (farnesyl-diphosphate synthase) 3189731 ispA 8193006 ispA Methylobacterium extorquens DM4 geranyltranstransferase (farnesyl-diphosphate synthase) YP_003068766.1 3188769 R 661410 CDS YP_003068767.1 254561672 8195606 3189768..3190553 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 8830253; Product type e : enzyme; monofunctional biosynthetic peptidoglycan transglycosylase 3190553 mgtA 8195606 mgtA Methylobacterium extorquens DM4 monofunctional biosynthetic peptidoglycan transglycosylase YP_003068767.1 3189768 D 661410 CDS YP_003068768.1 254561673 8195693 complement(3190558..3191961) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 7813451; Product type e : enzyme; deoxyribodipyrimidine photolyase (DNA photolyase) 3191961 phr 8195693 phr Methylobacterium extorquens DM4 deoxyribodipyrimidine photolyase (DNA photolyase) YP_003068768.1 3190558 R 661410 CDS YP_003068769.1 254561674 8195864 complement(3192581..3193702) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier; putative extracellular solute-binding protein family 7, twin-arginine translocation pathway signal 3193702 8195864 METDI3262 Methylobacterium extorquens DM4 putative extracellular solute-binding protein family 7, twin-arginine translocation pathway signal YP_003068769.1 3192581 R 661410 CDS YP_003068770.1 254561675 8193007 3193837..3194412 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 16926146; hypothetical protein 3194412 8193007 METDI3263 Methylobacterium extorquens DM4 hypothetical protein YP_003068770.1 3193837 D 661410 CDS YP_003068771.1 254561676 8193008 complement(3194422..3195546) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type prc : putative receptor; putative extracellular ligand-binding receptor precursor 3195546 8193008 METDI3264 Methylobacterium extorquens DM4 putative extracellular ligand-binding receptor precursor YP_003068771.1 3194422 R 661410 CDS YP_003068772.1 254561677 8193009 complement(3195866..3197038) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative capsule polysaccharide export outer membrane protein 3197038 8193009 METDI3265 Methylobacterium extorquens DM4 putative capsule polysaccharide export outer membrane protein YP_003068772.1 3195866 R 661410 CDS YP_003068773.1 254561678 8193010 complement(3197236..3198705) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative Capsular polysaccharide biosynthesis protein 3198705 8193010 METDI3266 Methylobacterium extorquens DM4 putative Capsular polysaccharide biosynthesis protein YP_003068773.1 3197236 R 661410 CDS YP_003068774.1 254561679 8193011 complement(3198712..3200661) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3200661 8193011 METDI3267 Methylobacterium extorquens DM4 hypothetical protein YP_003068774.1 3198712 R 661410 CDS YP_003068775.1 254561680 8193012 3201024..3202331 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10094710, 8397187; Product type pm : putative membrane component; putative capsular polysaccharide biosynthesis/export protein, (kpsS, Synonyms : wcbO) 3202331 8193012 METDI3268 Methylobacterium extorquens DM4 putative capsular polysaccharide biosynthesis/export protein, (kpsS, Synonyms : wcbO) YP_003068775.1 3201024 D 661410 CDS YP_003068776.1 254561681 8193013 3202388..3203155 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative oxidoreductase, short-chain dehydrogenase/reductase family 3203155 8193013 METDI3269 Methylobacterium extorquens DM4 putative oxidoreductase, short-chain dehydrogenase/reductase family YP_003068776.1 3202388 D 661410 CDS YP_003068777.1 254561682 8193014 3203155..3204012 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative Methionyl-tRNA formyltransferase (partial) 3204012 8193014 METDI3270 Methylobacterium extorquens DM4 putative Methionyl-tRNA formyltransferase (partial) YP_003068777.1 3203155 D 661410 CDS YP_003068778.1 254561683 8193015 complement(3204016..3205296) 1 NC_012988.1 catalyzes the formation of L-methionine and acetate from O-acetyl-L-homoserine and methanethiol; O-acetylhomoserine aminocarboxypropyltransferase 3205296 metY-2 8193015 metY-2 Methylobacterium extorquens DM4 O-acetylhomoserine aminocarboxypropyltransferase YP_003068778.1 3204016 R 661410 CDS YP_003068779.1 254561684 8195689 3205856..3206404 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 12597275, 2541921; Product type e : enzyme; Ubiquinol-cytochrome c reductase complex, iron-sulfur subunit (Rieske iron-sulfur protein) 3206404 petA 8195689 petA Methylobacterium extorquens DM4 Ubiquinol-cytochrome c reductase complex, iron-sulfur subunit (Rieske iron-sulfur protein) YP_003068779.1 3205856 D 661410 CDS YP_003068780.1 254561685 8195845 3206439..3207731 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 2176897, 2556259; Product type e : enzyme; Ubiquinol-cytochrome c reductase complex, cytochrome b subunit 3207731 petB 8195845 petB Methylobacterium extorquens DM4 Ubiquinol-cytochrome c reductase complex, cytochrome b subunit YP_003068780.1 3206439 D 661410 CDS YP_003068781.1 254561686 8195846 3207753..3208646 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 10873857, 11880631; Product type e : enzyme; Ubiquinol-cytochrome c reductase complex, cytochrome c1 subunit 3208646 petC 8195846 petC Methylobacterium extorquens DM4 Ubiquinol-cytochrome c reductase complex, cytochrome c1 subunit YP_003068781.1 3207753 D 661410 CDS YP_003068782.1 254561687 8195847 3208858..3209733 1 NC_012988.1 Catalyzes the reversible phosphorolysis of 5'-deoxy-5'- methylthioadenosine (MTA) to adenine and 5-methylthio-D-ribose-1- phosphate; 5'-methylthioadenosine phosphorylase 3209733 8195847 METDI3275 Methylobacterium extorquens DM4 5'-methylthioadenosine phosphorylase YP_003068782.1 3208858 D 661410 CDS YP_003068783.1 254561688 8193016 complement(3209838..3210098) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3210098 8193016 METDI3276 Methylobacterium extorquens DM4 hypothetical protein YP_003068783.1 3209838 R 661410 CDS YP_003068784.1 254561689 8193017 complement(3210133..3211038) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3211038 8193017 METDI3277 Methylobacterium extorquens DM4 hypothetical protein YP_003068784.1 3210133 R 661410 CDS YP_003068785.1 254561690 8193018 3211249..3211836 1 NC_012988.1 catalyzes the dehydration of D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate to 3-(imidazol-4-yl)-2-oxopropyl phosphate in histidine biosynthesis; imidazoleglycerol-phosphate dehydratase 3211836 hisB 8193018 hisB Methylobacterium extorquens DM4 imidazoleglycerol-phosphate dehydratase YP_003068785.1 3211249 D 661410 CDS YP_003068786.1 254561691 8195558 3211859..3212362 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3212362 8195558 METDI3279 Methylobacterium extorquens DM4 hypothetical protein YP_003068786.1 3211859 D 661410 CDS YP_003068787.1 254561692 8193019 3212359..3213021 1 NC_012988.1 with HisF IGPS catalyzes the conversion of phosphoribulosyl-formimino-5-aminoimidazole-4-carboxamide ribonucleotide phosphate and glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamide ribonucleotide, and glutamate in histidine biosynthesis; the HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of imidazole-glycerol phosphate and 5-aminoimidazol-4-carboxamide ribonucleotide; imidazole glycerol phosphate synthase subunit HisH 3213021 hisH 8193019 hisH Methylobacterium extorquens DM4 imidazole glycerol phosphate synthase subunit HisH YP_003068787.1 3212359 D 661410 CDS YP_003068788.1 254561693 8195564 3213063..3213830 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; N-(5'-phospho-L-ribosyl-formimino)-5-amino-1- (5'-phosphoribosyl)-4-imidazolecarboxamide isomerase 3213830 hisA 8195564 hisA Methylobacterium extorquens DM4 N-(5'-phospho-L-ribosyl-formimino)-5-amino-1- (5'-phosphoribosyl)-4-imidazolecarboxamide isomerase YP_003068788.1 3213063 D 661410 CDS YP_003068789.1 254561694 8195557 3213878..3214654 1 NC_012988.1 catalyzes the conversion of 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]- 1-(5-phosphoribosyl)imidazole-4-carboxamideand glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamideribonucleotide and glutamate; the HisF subunit acts as a cyclase; imidazole glycerol phosphate synthase subunit HisF 3214654 hisF 8195557 hisF Methylobacterium extorquens DM4 imidazole glycerol phosphate synthase subunit HisF YP_003068789.1 3213878 D 661410 CDS YP_003068790.1 254561695 8195562 3214775..3215098 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 2664449; Product type e : enzyme; phosphoribosyl-ATP pyrophosphatase 3215098 hisE 8195562 hisE Methylobacterium extorquens DM4 phosphoribosyl-ATP pyrophosphatase YP_003068790.1 3214775 D 661410 CDS YP_003068791.1 254561696 8195561 3215095..3216108 1 NC_012988.1 catalyzes the formation of (R)-4'-phosphopantothenate in coenzyme A biosynthesis; pantothenate kinase 3216108 coaA 8195561 coaA Methylobacterium extorquens DM4 pantothenate kinase YP_003068791.1 3215095 D 661410 CDS YP_003068792.1 254561697 8195177 complement(3216276..3217610) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type rc : receptor; methyl-accepting chemotaxis sensory transducer 3217610 8195177 METDI3285 Methylobacterium extorquens DM4 methyl-accepting chemotaxis sensory transducer YP_003068792.1 3216276 R 661410 CDS YP_003068793.1 254561698 8193020 3218528..3219673 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3219673 8193020 METDI3287 Methylobacterium extorquens DM4 hypothetical protein YP_003068793.1 3218528 D 661410 CDS YP_003068794.1 254561699 8193021 3219865..3220386 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative response regulator receiver (CheY-like protein) 3220386 8193021 METDI3288 Methylobacterium extorquens DM4 putative response regulator receiver (CheY-like protein) YP_003068794.1 3219865 D 661410 CDS YP_003068795.1 254561700 8193022 3220777..3221004 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3221004 8193022 METDI3289 Methylobacterium extorquens DM4 hypothetical protein YP_003068795.1 3220777 D 661410 CDS YP_003068796.1 254561701 8193023 3221137..3221808 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3221808 8193023 METDI3291 Methylobacterium extorquens DM4 hypothetical protein YP_003068796.1 3221137 D 661410 CDS YP_003068797.1 254561702 8193024 complement(3221929..3222255) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3222255 8193024 METDI3292 Methylobacterium extorquens DM4 hypothetical protein YP_003068797.1 3221929 R 661410 CDS YP_003068798.1 254561703 8193025 complement(3222463..3222903) 1 NC_012988.1 Evidence 1c : Function experimentally demonstrated in the studied genus; PubMedId : 12399487, 16926146; Product type f : factor; Granule-associated 20 kDa protein (phasin) 3222903 gap20 8193025 gap20 Methylobacterium extorquens DM4 Granule-associated 20 kDa protein (phasin) YP_003068798.1 3222463 R 661410 CDS YP_003068799.1 254561704 8195466 3223181..3225709 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative histidine kinase with HK Homodimeric domain, ATPase domain and a sensory PAS domain 3225709 8195466 METDI3294 Methylobacterium extorquens DM4 putative histidine kinase with HK Homodimeric domain, ATPase domain and a sensory PAS domain YP_003068799.1 3223181 D 661410 CDS YP_003068800.1 254561705 8193026 3225969..3227918 1 NC_012988.1 Acs; catalyzes the conversion of acetate and CoA to acetyl-CoA; acetyl-CoA synthetase 3227918 acs 8193026 acs Methylobacterium extorquens DM4 acetyl-CoA synthetase YP_003068800.1 3225969 D 661410 CDS YP_003068801.1 254561706 8195057 3228131..3228517 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 14563880; Product type pm : putative membrane component; hypothetical protein 3228517 8195057 METDI3296 Methylobacterium extorquens DM4 hypothetical protein YP_003068801.1 3228131 D 661410 CDS YP_003068802.1 254561707 8193027 3228514..3230199 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 14563880; Product type t : transporter; Cation/acetate symporter actP; acetate and glycolate permease 3230199 actP 8193027 actP Methylobacterium extorquens DM4 Cation/acetate symporter actP; acetate and glycolate permease YP_003068802.1 3228514 D 661410 CDS YP_003068803.1 254561708 8195060 3230506..3232194 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative MFS transporter membrane protein 3232194 8195060 METDI3298 Methylobacterium extorquens DM4 putative MFS transporter membrane protein YP_003068803.1 3230506 D 661410 CDS YP_003068804.1 254561709 8193028 complement(3232408..3234006) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 2192230, 2687276; Product type e : enzyme; bifunctional: IMP cyclohydrolase (N-terminal); phosphoribosylaminoimidazolecarboxamide formyltransferase (C-terminal) 3234006 purH 8193028 purH Methylobacterium extorquens DM4 bifunctional: IMP cyclohydrolase (N-terminal); phosphoribosylaminoimidazolecarboxamide formyltransferase (C-terminal) YP_003068804.1 3232408 R 661410 CDS YP_003068805.1 254561710 8195935 complement(3234230..3235921) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3235921 8195935 METDI3300 Methylobacterium extorquens DM4 hypothetical protein YP_003068805.1 3234230 R 661410 CDS YP_003068806.1 254561711 8193029 complement(3236130..3236978) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 11445076; Product type e : enzyme; 3-mercaptopyruvate sulfurtransferase 3236978 sseA 8193029 sseA Methylobacterium extorquens DM4 3-mercaptopyruvate sulfurtransferase YP_003068806.1 3236130 R 661410 CDS YP_003068807.1 254561712 8196148 3237251..3237487 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3237487 8196148 METDI3302 Methylobacterium extorquens DM4 hypothetical protein YP_003068807.1 3237251 D 661410 CDS YP_003068808.1 254561713 8193030 complement(3237598..3238683) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3238683 8193030 METDI3303 Methylobacterium extorquens DM4 hypothetical protein YP_003068808.1 3237598 R 661410 CDS YP_003068809.1 254561714 8193031 3239358..3240890 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 10361280, 14731278, 15196029, 15554979, 1931833, 94312114; Product type e : enzyme; RNA helicase 3240890 rhlE 8193031 rhlE Methylobacterium extorquens DM4 RNA helicase YP_003068809.1 3239358 D 661410 CDS YP_003068810.1 254561715 8195989 3241065..3241250 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3241250 8195989 METDI3305 Methylobacterium extorquens DM4 hypothetical protein YP_003068810.1 3241065 D 661410 CDS YP_003068811.1 254561716 8193032 3241377..3241661 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3241661 8193032 METDI3306 Methylobacterium extorquens DM4 hypothetical protein YP_003068811.1 3241377 D 661410 CDS YP_003068812.1 254561717 8193033 3241871..3242014 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3242014 8193033 METDI3307 Methylobacterium extorquens DM4 hypothetical protein YP_003068812.1 3241871 D 661410 CDS YP_003068813.1 254561718 8193034 3242102..3242521 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 15808744, 2985285; Product type pe : putative enzyme; acyl-CoA thioester hydrolase 3242521 yciA 8193034 yciA Methylobacterium extorquens DM4 acyl-CoA thioester hydrolase YP_003068813.1 3242102 D 661410 CDS YP_003068814.1 254561719 8196357 3242687..3243331 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative metal-binding hydrolase 3243331 ycbL 8196357 ycbL Methylobacterium extorquens DM4 putative metal-binding hydrolase YP_003068814.1 3242687 D 661410 CDS YP_003068815.1 254561720 8196354 3243570..3246017 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 1656869, 8226640; Product type e : enzyme; DNA gyrase, subunit B (type II topoisomerase) 3246017 gyrB 8196354 gyrB Methylobacterium extorquens DM4 DNA gyrase, subunit B (type II topoisomerase) YP_003068815.1 3243570 D 661410 CDS YP_003068816.1 254561721 8195544 complement(3246081..3246788) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type f : factor; RNA polymerase sigma factor 3246788 8195544 METDI3311 Methylobacterium extorquens DM4 RNA polymerase sigma factor YP_003068816.1 3246081 R 661410 CDS YP_003068817.1 254561722 8193035 3247215..3247640 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 9632260; Product type t : transporter; mechanosensitive channel 3247640 mscL 8193035 mscL Methylobacterium extorquens DM4 mechanosensitive channel YP_003068817.1 3247215 D 661410 CDS YP_003068818.1 254561723 8195725 complement(3247647..3247937) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3247937 8195725 METDI3313 Methylobacterium extorquens DM4 hypothetical protein YP_003068818.1 3247647 R 661410 CDS YP_003068819.1 254561724 8193036 complement(3248229..3248642) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 16926146; hypothetical protein 3248642 8193036 METDI3314 Methylobacterium extorquens DM4 hypothetical protein YP_003068819.1 3248229 R 661410 CDS YP_003068820.1 254561725 8193037 complement(3248825..3250006) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; aspartate transaminase 3250006 8193037 METDI3315 Methylobacterium extorquens DM4 aspartate transaminase YP_003068820.1 3248825 R 661410 CDS YP_003068821.1 254561726 8193038 complement(3250128..3250319) 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 3250319 8193038 METDI3316 Methylobacterium extorquens DM4 hypothetical protein YP_003068821.1 3250128 R 661410 CDS YP_003068822.1 254561727 8193039 complement(3250470..3251876) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type prc : putative receptor; putative integral membrane sensor signal transduction histidine kinase 3251876 8193039 METDI3317 Methylobacterium extorquens DM4 putative integral membrane sensor signal transduction histidine kinase YP_003068822.1 3250470 R 661410 CDS YP_003068823.1 254561728 8193040 complement(3251884..3252612) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 10464234, 2845093, 2997120, 3010044, 6292199, 91175693, 92165726, 93287101; Product type r : regulator; DNA-binding response regulator in two-component regulatory system with EnvZ 3252612 ompR 8193040 ompR Methylobacterium extorquens DM4 DNA-binding response regulator in two-component regulatory system with EnvZ YP_003068823.1 3251884 R 661410 CDS YP_003068824.1 254561729 8195807 complement(3252612..3253157) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type r : regulator; transcriptional regulator, MarR family 3253157 8195807 METDI3319 Methylobacterium extorquens DM4 transcriptional regulator, MarR family YP_003068824.1 3252612 R 661410 CDS YP_003068825.1 254561730 8193041 3253396..3254283 1 NC_012988.1 catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids; branched-chain amino acid aminotransferase 3254283 8193041 METDI3320 Methylobacterium extorquens DM4 branched-chain amino acid aminotransferase YP_003068825.1 3253396 D 661410 CDS YP_003068826.1 254561731 8193042 3254386..3254649 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3254649 8193042 METDI3321 Methylobacterium extorquens DM4 hypothetical protein YP_003068826.1 3254386 D 661410 CDS YP_003068827.1 254561732 8193043 3255033..3255140 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11359562, 9623911; Product type pf : putative factor; putative PilA2 pilus assembly protein, Flp/Fap pilin component 3255140 8193043 METDI3322 Methylobacterium extorquens DM4 putative PilA2 pilus assembly protein, Flp/Fap pilin component YP_003068827.1 3255033 D 661410 CDS YP_003068828.1 254561733 8193044 complement(3255290..3256060) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3256060 8193044 METDI3323 Methylobacterium extorquens DM4 hypothetical protein YP_003068828.1 3255290 R 661410 CDS YP_003068829.1 254561734 8193045 complement(3256298..3257779) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3257779 8193045 METDI3324 Methylobacterium extorquens DM4 hypothetical protein YP_003068829.1 3256298 R 661410 CDS YP_003068830.1 254561735 8193046 complement(3257772..3259670) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type t : transporter; potassium:proton antiporter 3259670 kefB 8193046 kefB Methylobacterium extorquens DM4 potassium:proton antiporter YP_003068830.1 3257772 R 661410 CDS YP_003068831.1 254561736 8195623 3260023..3261045 1 NC_012988.1 catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP); functions in the nonmevalonate isoprenoid biosynthesis pathway; 4-hydroxy-3-methylbut-2-enyl diphosphate reductase 3261045 ispH 8195623 ispH Methylobacterium extorquens DM4 4-hydroxy-3-methylbut-2-enyl diphosphate reductase YP_003068831.1 3260023 D 661410 CDS YP_003068832.1 254561737 8195611 3261144..3262109 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 10589737; Product type e : enzyme; homoserine kinase 3262109 thrB 8195611 thrB Methylobacterium extorquens DM4 homoserine kinase YP_003068832.1 3261144 D 661410 CDS YP_003068833.1 254561738 8196193 complement(3262158..3262640) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15188393, 16926146; Product type pe : putative enzyme; putative peroxiredoxin protein, antioxidant protein, AhpC/TSA family protein 3262640 8196193 METDI3328 Methylobacterium extorquens DM4 putative peroxiredoxin protein, antioxidant protein, AhpC/TSA family protein YP_003068833.1 3262158 R 661410 CDS YP_003068834.1 254561739 8193047 3262764..3263372 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3263372 8193047 METDI3329 Methylobacterium extorquens DM4 hypothetical protein YP_003068834.1 3262764 D 661410 CDS YP_003068835.1 254561740 8193048 complement(3263410..3264471) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3264471 8193048 METDI3330 Methylobacterium extorquens DM4 hypothetical protein YP_003068835.1 3263410 R 661410 CDS YP_003068836.1 254561741 8193049 complement(3264655..3267330) 1 NC_012988.1 Catalyzes a two-step reaction, first charging an alanyl molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; alanyl-tRNA synthetase 3267330 alaS 8193049 alaS Methylobacterium extorquens DM4 alanyl-tRNA synthetase YP_003068836.1 3264655 R 661410 CDS YP_003068837.1 254561742 8195067 complement(3267425..3268132) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3268132 8195067 METDI3332 Methylobacterium extorquens DM4 hypothetical protein YP_003068837.1 3267425 R 661410 CDS YP_003068838.1 254561743 8193050 3268207..3268809 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative glutathione S-transferase 3268809 8193050 METDI3333 Methylobacterium extorquens DM4 putative glutathione S-transferase YP_003068838.1 3268207 D 661410 CDS YP_003068839.1 254561744 8193051 complement(3268891..3269991) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; DNA strand exchange and recombination protein with protease and nuclease activity 3269991 recA 8193051 recA Methylobacterium extorquens DM4 DNA strand exchange and recombination protein with protease and nuclease activity YP_003068839.1 3268891 R 661410 CDS YP_003068840.1 254561745 8195967 complement(3270246..3272957) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 10199407; Product type r : regulator; sensor hybrid histidine kinase with multiple PAS and response regulator receiver domains 3272957 cckA 8195967 cckA Methylobacterium extorquens DM4 sensor hybrid histidine kinase with multiple PAS and response regulator receiver domains YP_003068840.1 3270246 R 661410 CDS YP_003068841.1 254561746 8195151 complement(3273116..3274180) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type f : factor; flagellar biosynthetic protein flhB 3274180 flhB 8195151 flhB Methylobacterium extorquens DM4 flagellar biosynthetic protein flhB YP_003068841.1 3273116 R 661410 CDS YP_003068842.1 254561747 8195412 complement(3274283..3275059) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type f : factor; flagellar biosynthetic protein FliR 3275059 fliR 8195412 fliR Methylobacterium extorquens DM4 flagellar biosynthetic protein FliR YP_003068842.1 3274283 R 661410 CDS YP_003068843.1 254561748 8195430 complement(3275105..3275371) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type f : factor; flagellar biosynthesis 3275371 fliQ 8195430 fliQ Methylobacterium extorquens DM4 flagellar biosynthesis YP_003068843.1 3275105 R 661410 CDS YP_003068844.1 254561749 8195428 complement(3275453..3275776) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type f : factor; Flagellar hook-basal body complex protein FliE 3275776 fliE 8195428 fliE Methylobacterium extorquens DM4 Flagellar hook-basal body complex protein FliE YP_003068844.1 3275453 R 661410 CDS YP_003068845.1 254561750 8195414 complement(3275782..3276192) 1 NC_012988.1 with FlgF and B makes up the proximal portion of the flagellar basal body rod; flagellar basal body rod protein FlgC 3276192 flgC 8195414 flgC Methylobacterium extorquens DM4 flagellar basal body rod protein FlgC YP_003068845.1 3275782 R 661410 CDS YP_003068846.1 254561751 8195394 complement(3276227..3276643) 1 NC_012988.1 with FlgF and C makes up the proximal portion of the flagellar basal body rod; Bradyrhizobium has one thick flagellum and several thin flagella; the protein in this cluster is associated with the thick flagellum; flagellar basal body rod protein FlgB 3276643 flgB 8195394 flgB Methylobacterium extorquens DM4 flagellar basal body rod protein FlgB YP_003068846.1 3276227 R 661410 CDS YP_003068847.1 254561752 8195392 3276975..3278186 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3278186 8195392 METDI3342 Methylobacterium extorquens DM4 hypothetical protein YP_003068847.1 3276975 D 661410 CDS YP_003068848.1 254561753 8193052 3278294..3279388 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; Oxidoreductase, FAD-binding family protein 3279388 8193052 METDI3343 Methylobacterium extorquens DM4 Oxidoreductase, FAD-binding family protein YP_003068848.1 3278294 D 661410 CDS YP_003068849.1 254561754 8193053 complement(3279391..3280230) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3280230 8193053 METDI3344 Methylobacterium extorquens DM4 hypothetical protein YP_003068849.1 3279391 R 661410 CDS YP_003068850.1 254561755 8193054 3280428..3281234 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 10339610, 12196152, 14532274, 1850420, 7635817; Product type t : transporter; heme exporter protein, cytochrome c-type biogenesis protein; ABC transporter, permease 3281234 ccmC 8193054 ccmC Methylobacterium extorquens DM4 heme exporter protein, cytochrome c-type biogenesis protein; ABC transporter, permease YP_003068850.1 3280428 D 661410 CDS YP_003068851.1 254561756 8195154 3281372..3281524 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 1850420, 8021193; Product type pm : putative membrane component; heme exporter protein D (cytochrome c-type biogenesis protein cycX) 3281524 ccmD 8195154 ccmD Methylobacterium extorquens DM4 heme exporter protein D (cytochrome c-type biogenesis protein cycX) YP_003068851.1 3281372 D 661410 CDS YP_003068852.1 254561757 8195155 3281521..3282141 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 11256948, 12196152, 9716493; Product type e : enzyme; Periplasmic protein thiol:disulfide oxidoreductase, cytochrome c-type biogenesis 3282141 ccmG 8195155 ccmG Methylobacterium extorquens DM4 Periplasmic protein thiol:disulfide oxidoreductase, cytochrome c-type biogenesis YP_003068852.1 3281521 D 661410 CDS YP_003068853.1 254561758 8195156 3282264..3283007 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative Fe-S oxidoreductase 3283007 8195156 METDI3348 Methylobacterium extorquens DM4 putative Fe-S oxidoreductase YP_003068853.1 3282264 D 661410 CDS YP_003068854.1 254561759 8193055 3283004..3284578 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative oxidoreductase, putative 4Fe-4S ferredoxin domain 3284578 8193055 METDI3349 Methylobacterium extorquens DM4 putative oxidoreductase, putative 4Fe-4S ferredoxin domain YP_003068854.1 3283004 D 661410 CDS YP_003068855.1 254561760 8193056 3284536..3285180 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3285180 8193056 METDI3350 Methylobacterium extorquens DM4 hypothetical protein YP_003068855.1 3284536 D 661410 CDS YP_003068856.1 254561761 8193057 3285268..3286128 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3286128 8193057 METDI3351 Methylobacterium extorquens DM4 hypothetical protein YP_003068856.1 3285268 D 661410 CDS YP_003068857.1 254561762 8193058 3286543..3287004 1 NC_012988.1 in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit; 50S ribosomal protein L13 3287004 rplM 8193058 rplM Methylobacterium extorquens DM4 50S ribosomal protein L13 YP_003068857.1 3286543 D 661410 CDS YP_003068858.1 254561763 8196022 3287001..3287492 1 NC_012988.1 forms a direct contact with the tRNA during translation; 30S ribosomal protein S9 3287492 rpsI 8196022 rpsI Methylobacterium extorquens DM4 30S ribosomal protein S9 YP_003068858.1 3287001 D 661410 CDS YP_003068859.1 254561764 8196060 3287575..3287949 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3287949 8196060 METDI3354 Methylobacterium extorquens DM4 hypothetical protein YP_003068859.1 3287575 D 661410 CDS YP_003068860.1 254561765 8193059 3288031..3288240 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type c : carrier; molybdenum-pterin binding protein 3288240 8193059 METDI3355 Methylobacterium extorquens DM4 molybdenum-pterin binding protein YP_003068860.1 3288031 D 661410 CDS YP_003068861.1 254561766 8193060 complement(3288253..3289131) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3289131 8193060 METDI3356 Methylobacterium extorquens DM4 hypothetical protein YP_003068861.1 3288253 R 661410 CDS YP_003068862.1 254561767 8193061 complement(3289194..3290984) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative ABC transporter, fused ATPase and transmembrane permease domains 3290984 8193061 METDI3357 Methylobacterium extorquens DM4 putative ABC transporter, fused ATPase and transmembrane permease domains YP_003068862.1 3289194 R 661410 CDS YP_003068863.1 254561768 8193062 3291145..3291315 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3291315 8193062 METDI3358 Methylobacterium extorquens DM4 hypothetical protein YP_003068863.1 3291145 D 661410 CDS YP_003068864.1 254561769 8193063 3291364..3291837 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3291837 8193063 METDI3359 Methylobacterium extorquens DM4 hypothetical protein YP_003068864.1 3291364 D 661410 CDS YP_003068865.1 254561770 8193064 3292752..3293108 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3293108 8193064 METDI3360 Methylobacterium extorquens DM4 hypothetical protein YP_003068865.1 3292752 D 661410 CDS YP_003068866.1 254561771 8196225 complement(3293683..3293901) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3293901 8196225 METDI3362 Methylobacterium extorquens DM4 hypothetical protein YP_003068866.1 3293683 R 661410 CDS YP_003068867.1 254561772 8193066 complement(3293898..3294569) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor; putative septum formation protein, Maf-like protein 3294569 8193066 METDI3363 Methylobacterium extorquens DM4 putative septum formation protein, Maf-like protein YP_003068867.1 3293898 R 661410 CDS YP_003068868.1 254561773 8196265 complement(3294853..3295224) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3295224 8196265 METDI3364 Methylobacterium extorquens DM4 hypothetical protein YP_003068868.1 3294853 R 661410 CDS YP_003068869.1 254561774 8193068 complement(3295125..3295430) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3295430 8193068 METDI3365 Methylobacterium extorquens DM4 hypothetical protein YP_003068869.1 3295125 R 661410 CDS YP_003068870.1 254561775 8193069 complement(3295484..3295834) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3295834 8193069 METDI3366 Methylobacterium extorquens DM4 hypothetical protein YP_003068870.1 3295484 R 661410 CDS YP_003068871.1 254561776 8193070 3296078..3297106 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3297106 8193070 METDI3367 Methylobacterium extorquens DM4 hypothetical protein YP_003068871.1 3296078 D 661410 CDS YP_003068872.1 254561777 8193071 3297117..3297479 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3297479 8193071 METDI3368 Methylobacterium extorquens DM4 hypothetical protein YP_003068872.1 3297117 D 661410 CDS YP_003068873.1 254561778 8193072 3298399..3299307 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3299307 8193072 METDI3369 Methylobacterium extorquens DM4 hypothetical protein YP_003068873.1 3298399 D 661410 CDS YP_003068874.1 254561779 8193073 complement(3299550..3299771) 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 3299771 8193073 METDI3371 Methylobacterium extorquens DM4 hypothetical protein YP_003068874.1 3299550 R 661410 CDS YP_003068875.1 254561780 8193074 complement(3300067..3300687) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3300687 8193074 METDI3372 Methylobacterium extorquens DM4 hypothetical protein YP_003068875.1 3300067 R 661410 CDS YP_003068876.1 254561781 8193075 complement(3300684..3300884) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3300884 8193075 METDI3373 Methylobacterium extorquens DM4 hypothetical protein YP_003068876.1 3300684 R 661410 CDS YP_003068877.1 254561782 8193076 complement(3300892..3301413) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3301413 8193076 METDI3374 Methylobacterium extorquens DM4 hypothetical protein YP_003068877.1 3300892 R 661410 CDS YP_003068878.1 254561783 8193078 complement(3301604..3301885) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3301885 8193078 METDI3376 Methylobacterium extorquens DM4 hypothetical protein YP_003068878.1 3301604 R 661410 CDS YP_003068879.1 254561784 8193079 complement(3301882..3302784) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3302784 8193079 METDI3377 Methylobacterium extorquens DM4 hypothetical protein YP_003068879.1 3301882 R 661410 CDS YP_003068880.1 254561785 8193080 3302909..3303178 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3303178 8193080 METDI3378 Methylobacterium extorquens DM4 hypothetical protein YP_003068880.1 3302909 D 661410 CDS YP_003068881.1 254561786 8193081 3303390..3304355 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative integrase 3304355 8193081 METDI3379 Methylobacterium extorquens DM4 putative integrase YP_003068881.1 3303390 D 661410 CDS YP_003068882.1 254561787 8193082 complement(3304496..3304675) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3304675 8193082 METDI3380 Methylobacterium extorquens DM4 hypothetical protein YP_003068882.1 3304496 R 661410 CDS YP_003068883.1 254561788 8193084 complement(3306692..3307996) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative integrase 3307996 8193084 METDI3382 Methylobacterium extorquens DM4 putative integrase YP_003068883.1 3306692 R 661410 CDS YP_003068884.1 254561789 8193085 complement(3307927..3308142) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3308142 8193085 METDI3383 Methylobacterium extorquens DM4 hypothetical protein YP_003068884.1 3307927 R 661410 CDS YP_003068885.1 254561790 8193086 complement(3308355..3308585) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3308585 8193086 METDI3384 Methylobacterium extorquens DM4 hypothetical protein YP_003068885.1 3308355 R 661410 CDS YP_003068886.1 254561791 8193087 complement(3308863..3309153) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3309153 8193087 METDI3385 Methylobacterium extorquens DM4 hypothetical protein YP_003068886.1 3308863 R 661410 CDS YP_003068887.1 254561792 8193088 complement(3309318..3311561) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type prc : putative receptor; putative TonB-dependent siderophore receptor 3311561 8193088 METDI3386 Methylobacterium extorquens DM4 putative TonB-dependent siderophore receptor YP_003068887.1 3309318 R 661410 CDS YP_003068888.1 254561793 8195030 3312246..3312377 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3312377 8195030 METDI3387 Methylobacterium extorquens DM4 hypothetical protein YP_003068888.1 3312246 D 661410 CDS YP_003068889.1 254561794 8193090 3312495..3312890 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3312890 8193090 METDI3388 Methylobacterium extorquens DM4 hypothetical protein YP_003068889.1 3312495 D 661410 CDS YP_003068890.1 254561795 8193091 3313021..3313284 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3313284 8193091 METDI3389 Methylobacterium extorquens DM4 hypothetical protein YP_003068890.1 3313021 D 661410 CDS YP_003068891.1 254561796 8193092 complement(3313328..3313993) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type t : transporter; heme exporter subunit ; membrane component of ABC superfamily 3313993 ccmB 8193092 ccmB Methylobacterium extorquens DM4 heme exporter subunit ; membrane component of ABC superfamily YP_003068891.1 3313328 R 661410 CDS YP_003068892.1 254561797 8195153 complement(3313993..3314814) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 10339610, 12196152, 1850420, 7635817; Product type t : transporter; heme export protein, cytochrome C-type biogenesis ccmA 3314814 ccmA 8195153 ccmA Methylobacterium extorquens DM4 heme export protein, cytochrome C-type biogenesis ccmA YP_003068892.1 3313993 R 661410 CDS YP_003068893.1 254561798 8195152 3314858..3315055 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3315055 8195152 METDI3392 Methylobacterium extorquens DM4 hypothetical protein YP_003068893.1 3314858 D 661410 CDS YP_003068894.1 254561799 8193093 3315362..3318061 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 10585860; Product type e : enzyme; aconitate hydratase 3318061 acnA 8193093 acnA Methylobacterium extorquens DM4 aconitate hydratase YP_003068894.1 3315362 D 661410 CDS YP_003068895.1 254561800 8195049 3318114..3318548 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3318548 8195049 METDI3394 Methylobacterium extorquens DM4 hypothetical protein YP_003068895.1 3318114 D 661410 CDS YP_003068896.1 254561801 8193094 3318657..3318956 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; Antibiotic biosynthesis monooxygenase 3318956 8193094 METDI3395 Methylobacterium extorquens DM4 Antibiotic biosynthesis monooxygenase YP_003068896.1 3318657 D 661410 CDS YP_003068897.1 254561802 8193095 3319082..3319729 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 11327815, 9396740, 9417084, 9925947; Product type e : enzyme; maleylacetoacetate isomerase (glutathione S-transferase) 3319729 maiA 8193095 maiA Methylobacterium extorquens DM4 maleylacetoacetate isomerase (glutathione S-transferase) YP_003068897.1 3319082 D 661410 CDS YP_003068898.1 254561803 8195659 3319886..3321217 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; respiratory NADH dehydrogenase 2; cupric reductase 3321217 ndh 8195659 ndh Methylobacterium extorquens DM4 respiratory NADH dehydrogenase 2; cupric reductase YP_003068898.1 3319886 D 661410 CDS YP_003068899.1 254561804 8195773 3321303..3321629 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 21528828; Product type pe : putative enzyme; putative Ethyl tert-butyl ether degradation EthD 3321629 8195773 METDI3398 Methylobacterium extorquens DM4 putative Ethyl tert-butyl ether degradation EthD YP_003068899.1 3321303 D 661410 CDS YP_003068900.1 254561805 8193096 3321629..3321940 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3321940 8193096 METDI3399 Methylobacterium extorquens DM4 hypothetical protein YP_003068900.1 3321629 D 661410 CDS YP_003068901.1 254561806 8193097 complement(3322021..3323394) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3323394 8193097 METDI3400 Methylobacterium extorquens DM4 hypothetical protein YP_003068901.1 3322021 R 661410 CDS YP_003068902.1 254561807 8193098 3323803..3324846 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative quinolinate synthetase A (nadA-like) 3324846 8193098 METDI3401 Methylobacterium extorquens DM4 putative quinolinate synthetase A (nadA-like) YP_003068902.1 3323803 D 661410 CDS YP_003068903.1 254561808 8193099 3324846..3326375 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative L-aspartate oxidase (nadB-like) 3326375 8193099 METDI3402 Methylobacterium extorquens DM4 putative L-aspartate oxidase (nadB-like) YP_003068903.1 3324846 D 661410 CDS YP_003068904.1 254561809 8193100 3326368..3327228 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 9862811; Product type e : enzyme; nicotinate-mononucleotide pyrophosphorylase 3327228 nadC 8193100 nadC Methylobacterium extorquens DM4 nicotinate-mononucleotide pyrophosphorylase YP_003068904.1 3326368 D 661410 CDS YP_003068905.1 254561810 8195767 3327544..3328212 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3328212 8195767 METDI3404 Methylobacterium extorquens DM4 hypothetical protein YP_003068905.1 3327544 D 661410 CDS YP_003068906.1 254561811 8193101 3328603..3328845 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3328845 8193101 METDI3406 Methylobacterium extorquens DM4 hypothetical protein YP_003068906.1 3328603 D 661410 CDS YP_003068907.1 254561812 8193102 complement(3328992..3329162) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3329162 8193102 METDI3407 Methylobacterium extorquens DM4 hypothetical protein YP_003068907.1 3328992 R 661410 CDS YP_003068908.1 254561813 8193103 complement(3329185..3329613) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3329613 8193103 METDI3408 Methylobacterium extorquens DM4 hypothetical protein YP_003068908.1 3329185 R 661410 CDS YP_003068909.1 254561814 8193104 3329756..3330790 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; molybdenum biosynthetic protein A 3330790 moaA 8193104 moaA Methylobacterium extorquens DM4 molybdenum biosynthetic protein A YP_003068909.1 3329756 D 661410 CDS YP_003068910.1 254561815 8195702 complement(3330797..3331717) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3331717 8195702 METDI3410 Methylobacterium extorquens DM4 hypothetical protein YP_003068910.1 3330797 R 661410 CDS YP_003068911.1 254561816 8193105 complement(3331618..3332814) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3332814 8193105 METDI3411 Methylobacterium extorquens DM4 hypothetical protein YP_003068911.1 3331618 R 661410 CDS YP_003068912.1 254561817 8193106 3333010..3333876 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative 2-hydroxy-3-oxopropionate reductase 3333876 8193106 METDI3412 Methylobacterium extorquens DM4 putative 2-hydroxy-3-oxopropionate reductase YP_003068912.1 3333010 D 661410 CDS YP_003068913.1 254561818 8193107 complement(3333854..3334807) 1 NC_012988.1 IPP transferase; isopentenyltransferase; involved in tRNA modification; in Escherichia coli this enzyme catalyzes the addition of a delta2-isopentenyl group from dimethylallyl diphosphate to the N6-nitrogen of adenosine adjacent to the anticodon of tRNA species that read codons starting with uracil; further tRNA modifications may occur; mutations in miaA result in defects in translation efficiency and fidelity; tRNA delta(2)-isopentenylpyrophosphate transferase 3334807 miaA 8193107 miaA Methylobacterium extorquens DM4 tRNA delta(2)-isopentenylpyrophosphate transferase YP_003068913.1 3333854 R 661410 CDS YP_003068914.1 254561819 8195694 3334819..3335715 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative phosphoserine phosphatase (serB-like) 3335715 8195694 METDI3414 Methylobacterium extorquens DM4 putative phosphoserine phosphatase (serB-like) YP_003068914.1 3334819 D 661410 CDS YP_003068915.1 254561820 8193108 complement(3335824..3337359) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative serine protease precursor 3337359 8193108 METDI3415 Methylobacterium extorquens DM4 putative serine protease precursor YP_003068915.1 3335824 R 661410 CDS YP_003068916.1 254561821 8193109 complement(3337471..3338412) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type r : regulator; HflC protein precursor, modulator for HflB protease specific for phage lambda cII repressor 3338412 hflC 8193109 hflC Methylobacterium extorquens DM4 HflC protein precursor, modulator for HflB protease specific for phage lambda cII repressor YP_003068916.1 3337471 R 661410 CDS YP_003068917.1 254561822 8195554 complement(3338409..3339557) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; protease subunit hflK 3339557 hflK 8195554 hflK Methylobacterium extorquens DM4 protease subunit hflK YP_003068917.1 3338409 R 661410 CDS YP_003068918.1 254561823 8195555 complement(3339849..3340349) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; dihydrofolate reductase 3340349 dfrA 8195555 dfrA Methylobacterium extorquens DM4 dihydrofolate reductase YP_003068918.1 3339849 R 661410 CDS YP_003068919.1 254561824 8195292 complement(3340349..3341143) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type e : enzyme; thymidylate synthetase 3341143 thyA 8195292 thyA Methylobacterium extorquens DM4 thymidylate synthetase YP_003068919.1 3340349 R 661410 CDS YP_003068920.1 254561825 8196196 complement(3341231..3342100) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3342100 8196196 METDI3420 Methylobacterium extorquens DM4 hypothetical protein YP_003068920.1 3341231 R 661410 CDS YP_003068921.1 254561826 8193110 3342527..3343180 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3343180 8193110 METDI3421 Methylobacterium extorquens DM4 hypothetical protein YP_003068921.1 3342527 D 661410 CDS YP_003068922.1 254561827 8193111 complement(3343231..3344631) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative cytochrome P450 hydroxylase superfamily proteins 3344631 8193111 METDI3422 Methylobacterium extorquens DM4 putative cytochrome P450 hydroxylase superfamily proteins YP_003068922.1 3343231 R 661410 CDS YP_003068923.1 254561828 8193112 3344757..3346175 1 NC_012988.1 Evidence 1b : Function experimentally demonstrated in the studied species; Product type e : enzyme; fumarase C 3346175 fumC 8193112 fumC Methylobacterium extorquens DM4 fumarase C YP_003068923.1 3344757 D 661410 CDS YP_003068924.1 254561829 8195460 3346236..3346424 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3346424 8195460 METDI3424 Methylobacterium extorquens DM4 hypothetical protein YP_003068924.1 3346236 D 661410 CDS YP_003068925.1 254561830 8193113 3346421..3346732 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3346732 8193113 METDI3425 Methylobacterium extorquens DM4 hypothetical protein YP_003068925.1 3346421 D 661410 CDS YP_003068926.1 254561831 8193114 complement(3346655..3347140) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3347140 8193114 METDI3426 Methylobacterium extorquens DM4 hypothetical protein YP_003068926.1 3346655 R 661410 CDS YP_003068927.1 254561832 8193115 complement(3347210..3348004) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3348004 8193115 METDI3427 Methylobacterium extorquens DM4 hypothetical protein YP_003068927.1 3347210 R 661410 CDS YP_003068928.1 254561833 8193116 complement(3348011..3348532) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; putative DedA family protein 3348532 8193116 METDI3428 Methylobacterium extorquens DM4 putative DedA family protein YP_003068928.1 3348011 R 661410 CDS YP_003068929.1 254561834 8193117 3348751..3349602 1 NC_012988.1 catalyzes the formation of pyridoxal 5'-phosphate from pyridoxal; pyridoxamine kinase 3349602 pdxY 8193117 pdxY Methylobacterium extorquens DM4 pyridoxamine kinase YP_003068929.1 3348751 D 661410 CDS YP_003068930.1 254561835 8195843 3349619..3350551 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 15449932, 15545603; Product type e : enzyme; Phenazine biosynthesis PhzC/PhzF-like protein 3350551 8195843 METDI3430 Methylobacterium extorquens DM4 Phenazine biosynthesis PhzC/PhzF-like protein YP_003068930.1 3349619 D 661410 CDS YP_003068931.1 254561836 8193118 3350541..3351272 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3351272 8193118 METDI3431 Methylobacterium extorquens DM4 hypothetical protein YP_003068931.1 3350541 D 661410 CDS YP_003068932.1 254561837 8193119 complement(3351284..3351610) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3351610 8193119 METDI3432 Methylobacterium extorquens DM4 hypothetical protein YP_003068932.1 3351284 R 661410 CDS YP_003068933.1 254561838 8193120 3352034..3353596 1 NC_012988.1 catalyzes the formation of 2-isopropylmalate from acetyl-CoA and 2-oxoisovalerate in leucine biosynthesis; 2-isopropylmalate synthase 3353596 leuA 8193120 leuA Methylobacterium extorquens DM4 2-isopropylmalate synthase YP_003068933.1 3352034 D 661410 CDS YP_003068934.1 254561839 8195628 3353789..3355624 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type e : enzyme; dihydroxyacid dehydratase 3355624 ilvD 8195628 ilvD Methylobacterium extorquens DM4 dihydroxyacid dehydratase YP_003068934.1 3353789 D 661410 CDS YP_003068935.1 254561840 8195594 3355913..3356923 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3356923 8195594 METDI3435 Methylobacterium extorquens DM4 hypothetical protein YP_003068935.1 3355913 D 661410 CDS YP_003068936.1 254561841 8193121 3356937..3357917 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 11747448; Product type e : enzyme; L-Ala-D/L-Glu epimerase 3357917 ycjG 8193121 ycjG Methylobacterium extorquens DM4 L-Ala-D/L-Glu epimerase YP_003068936.1 3356937 D 661410 CDS YP_003068937.1 254561842 8196358 complement(3357927..3359045) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3359045 8196358 METDI3437 Methylobacterium extorquens DM4 hypothetical protein YP_003068937.1 3357927 R 661410 CDS YP_003068938.1 254561843 8193122 3359361..3360554 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; inositol-3-phosphate synthase 3360554 8193122 METDI3438 Methylobacterium extorquens DM4 inositol-3-phosphate synthase YP_003068938.1 3359361 D 661410 CDS YP_003068939.1 254561844 8193123 3360609..3361487 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3361487 8193123 METDI3439 Methylobacterium extorquens DM4 hypothetical protein YP_003068939.1 3360609 D 661410 CDS YP_003068940.1 254561845 8193124 3361519..3362700 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3362700 8193124 METDI3440 Methylobacterium extorquens DM4 hypothetical protein YP_003068940.1 3361519 D 661410 CDS YP_003068941.1 254561846 8193125 3362700..3363728 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative oxidoreductase 3363728 8193125 METDI3441 Methylobacterium extorquens DM4 putative oxidoreductase YP_003068941.1 3362700 D 661410 CDS YP_003068942.1 254561847 8193126 3363921..3365540 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3365540 8193126 METDI3442 Methylobacterium extorquens DM4 hypothetical protein YP_003068942.1 3363921 D 661410 CDS YP_003068943.1 254561848 8193127 3365537..3366430 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10913097, 14996803; Product type pe : putative enzyme; putative glycosyl isomerase/epimerase 3366430 8193127 METDI3443 Methylobacterium extorquens DM4 putative glycosyl isomerase/epimerase YP_003068943.1 3365537 D 661410 CDS YP_003068944.1 254561849 8193128 3366427..3367665 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10048024, 8631780; Product type pe : putative enzyme; putative glycosyl transferase 3367665 8193128 METDI3444 Methylobacterium extorquens DM4 putative glycosyl transferase YP_003068944.1 3366427 D 661410 CDS YP_003068945.1 254561850 8193129 3367662..3368423 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 10094699, 10099135; hypothetical protein 3368423 8193129 METDI3445 Methylobacterium extorquens DM4 hypothetical protein YP_003068945.1 3367662 D 661410 CDS YP_003068946.1 254561851 8193130 3368407..3369033 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3369033 8193130 METDI3446 Methylobacterium extorquens DM4 hypothetical protein YP_003068946.1 3368407 D 661410 CDS YP_003068947.1 254561852 8193131 3369245..3370276 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3370276 8193131 METDI3447 Methylobacterium extorquens DM4 hypothetical protein YP_003068947.1 3369245 D 661410 CDS YP_003068948.1 254561853 8193132 3370300..3371589 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type r : regulator; PhoR-like sensor histidine kinase 3371589 8193132 METDI3448 Methylobacterium extorquens DM4 PhoR-like sensor histidine kinase YP_003068948.1 3370300 D 661410 CDS YP_003068949.1 254561854 8193133 3371790..3374288 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type t : transporter; copper-transporting P-type ATPase 3374288 8193133 METDI3449 Methylobacterium extorquens DM4 copper-transporting P-type ATPase YP_003068949.1 3371790 D 661410 CDS YP_003068950.1 254561855 8193134 3374285..3374749 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 11936079, 12213931; Product type r : regulator; heavy metal-dependent transcription regulator HmrR, putative copper efflux regulator CueR, MerR family 3374749 8193134 METDI3450 Methylobacterium extorquens DM4 heavy metal-dependent transcription regulator HmrR, putative copper efflux regulator CueR, MerR family YP_003068950.1 3374285 D 661410 CDS YP_003068951.1 254561856 8193135 3374837..3376003 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; amidohydrolase 3376003 8193135 METDI3451 Methylobacterium extorquens DM4 amidohydrolase YP_003068951.1 3374837 D 661410 CDS YP_003068952.1 254561857 8193136 complement(3376454..3377443) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative acyltransferase; membrane protein 3377443 8193136 METDI3453 Methylobacterium extorquens DM4 putative acyltransferase; membrane protein YP_003068952.1 3376454 R 661410 CDS YP_003068953.1 254561858 8193138 complement(3378471..3379496) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 12427942, 96079944; Product type e : enzyme; tRNA pseudouridine synthase B (tRNA pseudouridine 55 synthase) (Psi55 synthase) (tRNA-uridine isomerase) (tRNA pseudouridylate synthase) 3379496 truB 8193138 truB Methylobacterium extorquens DM4 tRNA pseudouridine synthase B (tRNA pseudouridine 55 synthase) (Psi55 synthase) (tRNA-uridine isomerase) (tRNA pseudouridylate synthase) YP_003068953.1 3378471 R 661410 CDS YP_003068954.1 254561859 8196281 complement(3379705..3380142) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 7535280, 9422595; Product type s : structure; ribosome-binding factor A 3380142 rbfA 8196281 rbfA Methylobacterium extorquens DM4 ribosome-binding factor A YP_003068954.1 3379705 R 661410 CDS YP_003068955.1 254561860 8195965 complement(3380245..3383214) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 14532131, 14691238, 1764105, 18059, 92075771, 1805969, 92260539, 99355440; Product type f : factor; Translation initiation factor IF-2 3383214 infB 8195965 infB Methylobacterium extorquens DM4 Translation initiation factor IF-2 YP_003068955.1 3380245 R 661410 CDS YP_003068956.1 254561861 8195598 complement(3383279..3384031) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3384031 8195598 METDI3460 Methylobacterium extorquens DM4 hypothetical protein YP_003068956.1 3383279 R 661410 CDS YP_003068957.1 254561862 8193139 complement(3384064..3385701) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type f : factor; transcription termination/antitermination L factor 3385701 nusA 8193139 nusA Methylobacterium extorquens DM4 transcription termination/antitermination L factor YP_003068957.1 3384064 R 661410 CDS YP_003068958.1 254561863 8195801 complement(3385815..3386570) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3386570 8195801 METDI3462 Methylobacterium extorquens DM4 hypothetical protein YP_003068958.1 3385815 R 661410 CDS YP_003068959.1 254561864 8193140 3386855..3387508 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type e : enzyme; Streptogramin A acetyltransferase (Virginiamycin acetyltransferase D) 3387508 vatD 8193140 vatD Methylobacterium extorquens DM4 Streptogramin A acetyltransferase (Virginiamycin acetyltransferase D) YP_003068959.1 3386855 D 661410 CDS YP_003068960.1 254561865 8196334 complement(3387445..3387621) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3387621 8196334 METDI3464 Methylobacterium extorquens DM4 hypothetical protein YP_003068960.1 3387445 R 661410 CDS YP_003068961.1 254561866 8193141 complement(3387836..3388870) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 9163523; Product type e : enzyme; aspartate-semialdehyde dehydrogenase 3388870 asdB 8193141 asdB Methylobacterium extorquens DM4 aspartate-semialdehyde dehydrogenase YP_003068961.1 3387836 R 661410 CDS YP_003068962.1 254561867 8195108 3389204..3390085 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3390085 8195108 METDI3466 Methylobacterium extorquens DM4 hypothetical protein YP_003068962.1 3389204 D 661410 CDS YP_003068963.1 254561868 8193142 3390199..3390612 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3390612 8193142 METDI3467 Methylobacterium extorquens DM4 hypothetical protein YP_003068963.1 3390199 D 661410 CDS YP_003068964.1 254561869 8193143 complement(3390676..3391224) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 8077207; Product type e : enzyme; spermidine N1-acetyltransferase 3391224 speG 8193143 speG Methylobacterium extorquens DM4 spermidine N1-acetyltransferase YP_003068964.1 3390676 R 661410 CDS YP_003068965.1 254561870 8196142 complement(3391308..3391601) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3391601 8196142 METDI3469 Methylobacterium extorquens DM4 hypothetical protein YP_003068965.1 3391308 R 661410 CDS YP_003068966.1 254561871 8193144 complement(3391720..3392940) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 14556637, 2013568, 7765511; Product type pr : putative regulator; putative regulatory protein (nitrile hydratase activator like), putative GTPase, putative cobalamin biosynthesis protein (CobW homolog) 3392940 8193144 METDI3470 Methylobacterium extorquens DM4 putative regulatory protein (nitrile hydratase activator like), putative GTPase, putative cobalamin biosynthesis protein (CobW homolog) YP_003068966.1 3391720 R 661410 CDS YP_003068967.1 254561872 8193145 3393166..3393792 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type r : regulator; putative transcriptional regulator, TetR family 3393792 8193145 METDI3471 Methylobacterium extorquens DM4 putative transcriptional regulator, TetR family YP_003068967.1 3393166 D 661410 CDS YP_003068968.1 254561873 8193146 3393958..3394437 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3394437 8193146 METDI3472 Methylobacterium extorquens DM4 hypothetical protein YP_003068968.1 3393958 D 661410 CDS YP_003068969.1 254561874 8193147 3394691..3396496 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11055902; Product type pe : putative enzyme; putative malto-oligosyltrehalose trehalohydrolase 3396496 8193147 METDI3473 Methylobacterium extorquens DM4 putative malto-oligosyltrehalose trehalohydrolase YP_003068969.1 3394691 D 661410 CDS YP_003068970.1 254561875 8193148 3396508..3401433 1 NC_012988.1 amylomaltase; acts to release glucose from maltodextrins; putative bifunctional 4-alpha-glucanotransferase/malto-oligosyltrehalose synthase 3401433 8193148 METDI3474 Methylobacterium extorquens DM4 putative bifunctional 4-alpha-glucanotransferase/malto-oligosyltrehalose synthase YP_003068970.1 3396508 D 661410 CDS YP_003068971.1 254561876 8193149 3401572..3404946 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10542168; Product type pe : putative enzyme; putative glycosyl hydrolase, catalytic domain 3404946 8193149 METDI3475 Methylobacterium extorquens DM4 putative glycosyl hydrolase, catalytic domain YP_003068971.1 3401572 D 661410 CDS YP_003068972.1 254561877 8193152 complement(3406398..3407630) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 10572129, 15727835; Product type e : enzyme; MiaB-like tRNA modifying enzyme, putative 2-methylthioadenine synthetase 3407630 8193152 METDI3478 Methylobacterium extorquens DM4 MiaB-like tRNA modifying enzyme, putative 2-methylthioadenine synthetase YP_003068972.1 3406398 R 661410 CDS YP_003068973.1 254561878 8193153 complement(3407627..3408484) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 3031013; Product type e : enzyme; diaminopimelate epimerase 3408484 dapF 8193153 dapF Methylobacterium extorquens DM4 diaminopimelate epimerase YP_003068973.1 3407627 R 661410 CDS YP_003068974.1 254561879 8195274 3408714..3409475 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3409475 8195274 METDI3480 Methylobacterium extorquens DM4 hypothetical protein YP_003068974.1 3408714 D 661410 CDS YP_003068975.1 254561880 8193154 3409525..3410289 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3410289 8193154 METDI3481 Methylobacterium extorquens DM4 hypothetical protein YP_003068975.1 3409525 D 661410 CDS YP_003068976.1 254561881 8193155 3410145..3410333 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 3410333 8193155 METDI3482 Methylobacterium extorquens DM4 hypothetical protein YP_003068976.1 3410145 D 661410 CDS YP_003068977.1 254561882 8193156 complement(3410321..3411436) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative photolyase 3411436 8193156 METDI3483 Methylobacterium extorquens DM4 putative photolyase YP_003068977.1 3410321 R 661410 CDS YP_003068978.1 254561883 8193157 3411541..3411813 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 3411813 8193157 METDI3484 Methylobacterium extorquens DM4 hypothetical protein YP_003068978.1 3411541 D 661410 CDS YP_003068979.1 254561884 8193158 3411908..3412237 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3412237 8193158 METDI3485 Methylobacterium extorquens DM4 hypothetical protein YP_003068979.1 3411908 D 661410 CDS YP_003068980.1 254561885 8193159 complement(3412259..3414613) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; 1,4-alpha-glucan branching enzyme 3414613 glgB 8193159 glgB Methylobacterium extorquens DM4 1,4-alpha-glucan branching enzyme YP_003068980.1 3412259 R 661410 CDS YP_003068981.1 254561886 8195489 complement(3414676..3417108) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16052332; Product type pe : putative enzyme; putative trehalose synthase 3417108 8195489 METDI3487 Methylobacterium extorquens DM4 putative trehalose synthase YP_003068981.1 3414676 R 661410 CDS YP_003068982.1 254561887 8193160 complement(3416997..3417404) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3417404 8193160 METDI3488 Methylobacterium extorquens DM4 hypothetical protein YP_003068982.1 3416997 R 661410 CDS YP_003068983.1 254561888 8193161 3417496..3418962 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 15060054, 20026843, 20141178, 88121727, 90279500, 92357006, 99326417; Product type f : factor; fused Signal Recognition Particle (SRP) receptor: membrane binding protein 3418962 ftsY 8193161 ftsY Methylobacterium extorquens DM4 fused Signal Recognition Particle (SRP) receptor: membrane binding protein YP_003068983.1 3417496 D 661410 CDS YP_003068984.1 254561889 8195456 3419002..3419622 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15919996; Product type pm : putative membrane component; putative intracellular septation protein (IspA/IspZ family) 3419622 8195456 METDI3490 Methylobacterium extorquens DM4 putative intracellular septation protein (IspA/IspZ family) YP_003068984.1 3419002 D 661410 CDS YP_003068985.1 254561890 8193162 complement(3419629..3420528) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; hydroxyneurosporene synthase CrtC 3420528 crtC 8193162 crtC Methylobacterium extorquens DM4 hydroxyneurosporene synthase CrtC YP_003068985.1 3419629 R 661410 CDS YP_003068986.1 254561891 8195217 complement(3420525..3422024) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 1612412, 2144293, 2747617, 7721699; Product type e : enzyme; FAD-dependent oxidoreductase precursor, putative phytoene dehydrogenase precursor 3422024 8195217 METDI3492 Methylobacterium extorquens DM4 FAD-dependent oxidoreductase precursor, putative phytoene dehydrogenase precursor YP_003068986.1 3420525 R 661410 CDS YP_003068987.1 254561892 8193163 3422130..3422996 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; geranylgeranyl pyrophosphate synthase 3422996 crtE 8193163 crtE Methylobacterium extorquens DM4 geranylgeranyl pyrophosphate synthase YP_003068987.1 3422130 D 661410 CDS YP_003068988.1 254561893 8195218 3423018..3424163 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; hydroxyneurosporene methyltransferase CrtF 3424163 crtF 8195218 crtF Methylobacterium extorquens DM4 hydroxyneurosporene methyltransferase CrtF YP_003068988.1 3423018 D 661410 CDS YP_003068989.1 254561894 8195219 3424265..3425203 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide a dehydrogenase 3425203 bchC 8195219 bchC Methylobacterium extorquens DM4 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide a dehydrogenase YP_003068989.1 3424265 D 661410 CDS YP_003068990.1 254561895 8195126 3425200..3426204 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; bacteriochlorophyllide reductase iron protein subunit BchX 3426204 bchX 8195126 bchX Methylobacterium extorquens DM4 bacteriochlorophyllide reductase iron protein subunit BchX YP_003068990.1 3425200 D 661410 CDS YP_003068991.1 254561896 8195137 3426208..3427734 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; bacteriochlorophyllide reductase subunit BchY 3427734 bchY 8195137 bchY Methylobacterium extorquens DM4 bacteriochlorophyllide reductase subunit BchY YP_003068991.1 3426208 D 661410 CDS YP_003068992.1 254561897 8195138 3427734..3429200 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; bacteriochlorophyllide reductase subunit 3429200 bchZ 8195138 bchZ Methylobacterium extorquens DM4 bacteriochlorophyllide reductase subunit YP_003068992.1 3427734 D 661410 CDS YP_003068993.1 254561898 8195139 3429296..3429505 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3429505 8195139 METDI3499 Methylobacterium extorquens DM4 hypothetical protein YP_003068993.1 3429296 D 661410 CDS YP_003068994.1 254561899 8193164 3429674..3429904 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type m : membrane component; light-harvesting complex 1 beta chain 3429904 pufB 8193164 pufB Methylobacterium extorquens DM4 light-harvesting complex 1 beta chain YP_003068994.1 3429674 D 661410 CDS YP_003068995.1 254561900 8195924 3429916..3430104 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type m : membrane component; light-harvesting complex 1 alpha chain 3430104 pufA 8195924 pufA Methylobacterium extorquens DM4 light-harvesting complex 1 alpha chain YP_003068995.1 3429916 D 661410 CDS YP_003068996.1 254561901 8195923 3430180..3431004 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type m : membrane component; photosynthetic reaction center subunit L 3431004 pufL 8195923 pufL Methylobacterium extorquens DM4 photosynthetic reaction center subunit L YP_003068996.1 3430180 D 661410 CDS YP_003068997.1 254561902 8195926 3431127..3432104 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type m : membrane component; photosynthetic reaction center subunit M 3432104 pufM 8195926 pufM Methylobacterium extorquens DM4 photosynthetic reaction center subunit M YP_003068997.1 3431127 D 661410 CDS YP_003068998.1 254561903 8195927 3432101..3433210 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type f : factor; photosynthetic reaction center cytochrome c subunit-related 3433210 pufC 8195927 pufC Methylobacterium extorquens DM4 photosynthetic reaction center cytochrome c subunit-related YP_003068998.1 3432101 D 661410 CDS YP_003068999.1 254561904 8195925 3433608..3435356 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative type I secretion system ATPase 3435356 8195925 METDI3505 Methylobacterium extorquens DM4 putative type I secretion system ATPase YP_003068999.1 3433608 D 661410 CDS YP_003069000.1 254561905 8193165 3435356..3436702 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative type I secretion membrane fusion protein, HlyD family 3436702 8193165 METDI3506 Methylobacterium extorquens DM4 putative type I secretion membrane fusion protein, HlyD family YP_003069000.1 3435356 D 661410 CDS YP_003069001.1 254561906 8193166 3436855..3436980 1 NC_012988.1 smallest protein in the large subunit; similar to what is found with protein L31 and L33 several bacterial genomes contain paralogs which may be regulated by zinc; the protein from Thermus thermophilus has a zinc-binding motif and contains a bound zinc ion; the proteins in this group do not have the motif; 50S ribosomal protein L36 3436980 rpmJ 8193166 rpmJ Methylobacterium extorquens DM4 50S ribosomal protein L36 YP_003069001.1 3436855 D 661410 CDS YP_003069002.1 254561907 8196043 3437058..3437666 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure; putative tetratrico peptide repeat (TPR) protein precursor 3437666 8196043 METDI3508 Methylobacterium extorquens DM4 putative tetratrico peptide repeat (TPR) protein precursor YP_003069002.1 3437058 D 661410 CDS YP_003069003.1 254561908 8193167 3437677..3438672 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 9244287; Product type pe : putative enzyme; putative alpha/beta hydrolase, putative haloalkane dehalogenase 3438672 8193167 METDI3509 Methylobacterium extorquens DM4 putative alpha/beta hydrolase, putative haloalkane dehalogenase YP_003069003.1 3437677 D 661410 CDS YP_003069004.1 254561909 8193168 complement(3438724..3440160) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; Pyruvate kinase 3440160 pyk 8193168 pyk Methylobacterium extorquens DM4 Pyruvate kinase YP_003069004.1 3438724 R 661410 CDS YP_003069005.1 254561910 8195945 3440528..3441385 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; putative outer membrane protein 3441385 8195945 METDI3511 Methylobacterium extorquens DM4 putative outer membrane protein YP_003069005.1 3440528 D 661410 CDS YP_003069006.1 254561911 8193169 complement(3441713..3442168) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3442168 8193169 METDI3512 Methylobacterium extorquens DM4 hypothetical protein YP_003069006.1 3441713 R 661410 CDS YP_003069007.1 254561912 8193170 complement(3442221..3443534) 1 NC_012988.1 Evidence 1c : Function experimentally demonstrated in the studied genus; PubMedId : 9244287; Product type e : enzyme; glycerate kinase 3443534 gck 8193170 gck Methylobacterium extorquens DM4 glycerate kinase YP_003069007.1 3442221 R 661410 CDS YP_003069008.1 254561913 8195473 3443762..3444535 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3444535 8195473 METDI3514 Methylobacterium extorquens DM4 hypothetical protein YP_003069008.1 3443762 D 661410 CDS YP_003069009.1 254561914 8193171 3444594..3444914 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3444914 8193171 METDI3515 Methylobacterium extorquens DM4 hypothetical protein YP_003069009.1 3444594 D 661410 CDS YP_003069010.1 254561915 8193172 3445019..3445285 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3445285 8193172 METDI3516 Methylobacterium extorquens DM4 hypothetical protein YP_003069010.1 3445019 D 661410 CDS YP_003069011.1 254561916 8193173 complement(3445510..3447000) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3447000 8193173 METDI3517 Methylobacterium extorquens DM4 hypothetical protein YP_003069011.1 3445510 R 661410 CDS YP_003069012.1 254561917 8193174 complement(3447236..3449176) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3449176 8193174 METDI3518 Methylobacterium extorquens DM4 hypothetical protein YP_003069012.1 3447236 R 661410 CDS YP_003069013.1 254561918 8193175 complement(3449423..3450913) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 11064198, 11158352, 2520824, 9287006; Product type r : regulator; two-component sigma-54 specific transcriptional regulator, Fis subfamily; with N-terminal response receiver, GAF and putative ATPase domains 3450913 8193175 METDI3519 Methylobacterium extorquens DM4 two-component sigma-54 specific transcriptional regulator, Fis subfamily; with N-terminal response receiver, GAF and putative ATPase domains YP_003069013.1 3449423 R 661410 CDS YP_003069014.1 254561919 8193176 3451242..3453119 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 9209029; Product type pe : putative enzyme; putative oligoendopeptidase F 3453119 8193176 METDI3520 Methylobacterium extorquens DM4 putative oligoendopeptidase F YP_003069014.1 3451242 D 661410 CDS YP_003069015.1 254561920 8193177 3453195..3453419 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3453419 8193177 METDI3521 Methylobacterium extorquens DM4 hypothetical protein YP_003069015.1 3453195 D 661410 CDS YP_003069016.1 254561921 8193178 3453416..3453802 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 12749835, 8411153, 9157244; Product type h : extrachromosomal origin; Death-on-curing family protein 3453802 doc 8193178 doc Methylobacterium extorquens DM4 Death-on-curing family protein YP_003069016.1 3453416 D 661410 CDS YP_003069017.1 254561922 8195313 3453895..3455265 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3455265 8195313 METDI3523 Methylobacterium extorquens DM4 hypothetical protein YP_003069017.1 3453895 D 661410 CDS YP_003069018.1 254561923 8193179 3455378..3455671 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3455671 8193179 METDI3524 Methylobacterium extorquens DM4 hypothetical protein YP_003069018.1 3455378 D 661410 CDS YP_003069019.1 254561924 8193180 3455783..3456922 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 15188393, 16926146, 8075801; Product type e : enzyme; NAD(P)+ transhydrogenase, subunit alpha part 1 3456922 pntAA 8193180 pntAA Methylobacterium extorquens DM4 NAD(P)+ transhydrogenase, subunit alpha part 1 YP_003069019.1 3455783 D 661410 CDS YP_003069020.1 254561925 8195871 3456944..3457396 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; NAD(P) transhydrogenase, subunit alpha part 2 3457396 pntAB 8195871 pntAB Methylobacterium extorquens DM4 NAD(P) transhydrogenase, subunit alpha part 2 YP_003069020.1 3456944 D 661410 CDS YP_003069021.1 254561926 8195872 3457401..3458801 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 11004437, 11250201; Product type e : enzyme; NAD(P) transhydrogenase, subunit beta 3458801 pntB 8195872 pntB Methylobacterium extorquens DM4 NAD(P) transhydrogenase, subunit beta YP_003069021.1 3457401 D 661410 CDS YP_003069022.1 254561927 8195873 3458896..3460731 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10498723, 10784047, 11085266, 12923078, 1987126, 264988; Product type pe : putative enzyme; putative single-strand DNA-specific exonuclease RecJ 3460731 recJ 8195873 recJ Methylobacterium extorquens DM4 putative single-strand DNA-specific exonuclease RecJ YP_003069022.1 3458896 D 661410 CDS YP_003069023.1 254561928 8196271 3461189..3461923 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcriptional regulator, Crp/Fnr family 3461923 8196271 METDI3529 Methylobacterium extorquens DM4 putative transcriptional regulator, Crp/Fnr family YP_003069023.1 3461189 D 661410 CDS YP_003069024.1 254561929 8193181 3461975..3462679 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative signal transduction histidine kinase of the HWE family 3462679 8193181 METDI3530 Methylobacterium extorquens DM4 putative signal transduction histidine kinase of the HWE family YP_003069024.1 3461975 D 661410 CDS YP_003069025.1 254561930 8193182 3462883..3464868 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 3464868 8193182 METDI3531 Methylobacterium extorquens DM4 hypothetical protein YP_003069025.1 3462883 D 661410 CDS YP_003069026.1 254561931 8193183 3464953..3469260 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3469260 8193183 METDI3532 Methylobacterium extorquens DM4 hypothetical protein YP_003069026.1 3464953 D 661410 CDS YP_003069027.1 254561932 8193184 3469730..3469990 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3469990 8193184 METDI3533 Methylobacterium extorquens DM4 hypothetical protein YP_003069027.1 3469730 D 661410 CDS YP_003069028.1 254561933 8193185 3470183..3470452 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3470452 8193185 METDI3534 Methylobacterium extorquens DM4 hypothetical protein YP_003069028.1 3470183 D 661410 CDS YP_003069029.1 254561934 8193186 complement(3470554..3471042) 1 NC_012988.1 catalyzes the reaction of cyanate and bicarbonate to produce ammonia and carbon dioxide; cyanate hydratase 3471042 cynS 8193186 cynS Methylobacterium extorquens DM4 cyanate hydratase YP_003069029.1 3470554 R 661410 CDS YP_003069030.1 254561935 8195241 3471331..3473220 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 2792368, 3313281, 3357773; Product type pr : putative regulator; putative sigma-54 specific transcriptional regulator, Fis subfamily; ATPase and PAS domains 3473220 8195241 METDI3537 Methylobacterium extorquens DM4 putative sigma-54 specific transcriptional regulator, Fis subfamily; ATPase and PAS domains YP_003069030.1 3471331 D 661410 CDS YP_003069031.1 254561936 8193187 3473383..3474909 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3474909 8193187 METDI3538 Methylobacterium extorquens DM4 hypothetical protein YP_003069031.1 3473383 D 661410 CDS YP_003069032.1 254561937 8193188 complement(3474934..3475992) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8021187; Product type pe : putative enzyme; putative di-haem cytochrome c peroxidase 3475992 8193188 METDI3539 Methylobacterium extorquens DM4 putative di-haem cytochrome c peroxidase YP_003069032.1 3474934 R 661410 CDS YP_003069033.1 254561938 8193189 complement(3476162..3476473) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3476473 8193189 METDI3540 Methylobacterium extorquens DM4 hypothetical protein YP_003069033.1 3476162 R 661410 CDS YP_003069034.1 254561939 8193190 3476717..3479581 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative diguanylate cyclase (GGDEF) /phosphodiesterase (EAL), with PAS sensor, signal transduction histidine kinase and methyl-accepting chemotaxis domains; putative membrane-associated protein 3479581 8193190 METDI3541 Methylobacterium extorquens DM4 putative diguanylate cyclase (GGDEF) /phosphodiesterase (EAL), with PAS sensor, signal transduction histidine kinase and methyl-accepting chemotaxis domains; putative membrane-associated protein YP_003069034.1 3476717 D 661410 CDS YP_003069035.1 254561940 8193191 3479816..3480673 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative manganese catalase 3480673 8193191 METDI3542 Methylobacterium extorquens DM4 putative manganese catalase YP_003069035.1 3479816 D 661410 CDS YP_003069036.1 254561941 8193192 3480752..3481261 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3481261 8193192 METDI3543 Methylobacterium extorquens DM4 hypothetical protein YP_003069036.1 3480752 D 661410 CDS YP_003069037.1 254561942 8193193 complement(3481451..3482122) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative spermidine synthase 3482122 8193193 METDI3544 Methylobacterium extorquens DM4 putative spermidine synthase YP_003069037.1 3481451 R 661410 CDS YP_003069038.1 254561943 8193194 3482211..3482462 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3482462 8193194 METDI3545 Methylobacterium extorquens DM4 hypothetical protein YP_003069038.1 3482211 D 661410 CDS YP_003069039.1 254561944 8196229 3482753..3484696 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type t : transporter; putative chloride channel protein 3484696 8196229 METDI3546 Methylobacterium extorquens DM4 putative chloride channel protein YP_003069039.1 3482753 D 661410 CDS YP_003069040.1 254561945 8193196 3484725..3485213 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3485213 8193196 METDI3547 Methylobacterium extorquens DM4 hypothetical protein YP_003069040.1 3484725 D 661410 CDS YP_003069041.1 254561946 8193197 3485224..3486072 1 NC_012988.1 catalyzes the formation of 2-dehydro-3-deoxy-D-octonate 8-phosphate from phosphoenolpyruvate and D-arabinose 5-phosphate in LPS biosynthesis; 2-dehydro-3-deoxyphosphooctonate aldolase 3486072 kdsA 8193197 kdsA Methylobacterium extorquens DM4 2-dehydro-3-deoxyphosphooctonate aldolase YP_003069041.1 3485224 D 661410 CDS YP_003069042.1 254561947 8195619 3486249..3486560 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3486560 8195619 METDI3549 Methylobacterium extorquens DM4 hypothetical protein YP_003069042.1 3486249 D 661410 CDS YP_003069043.1 254561948 8193198 complement(3486890..3487351) 1 NC_012988.1 NADPH-dependent; catalyzes the reduction of 7-cyano-7-deazaguanine to 7-aminomethyl-7-deazaguanine in queuosine biosynthesis; 7-cyano-7-deazaguanine reductase 3487351 8193198 METDI3550 Methylobacterium extorquens DM4 7-cyano-7-deazaguanine reductase YP_003069043.1 3486890 R 661410 CDS YP_003069044.1 254561949 8193199 3487643..3488932 1 NC_012988.1 enolase; catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis; phosphopyruvate hydratase 3488932 eno 8193199 eno Methylobacterium extorquens DM4 phosphopyruvate hydratase YP_003069044.1 3487643 D 661410 CDS YP_003069045.1 254561950 8195330 3489068..3489379 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type s : structure; Septum formation initiator 3489379 8195330 METDI3552 Methylobacterium extorquens DM4 Septum formation initiator YP_003069045.1 3489068 D 661410 CDS YP_003069046.1 254561951 8193200 3489555..3490604 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type e : enzyme; pyruvate dehydrogenase E1 alpha subunit 3490604 pdhA 8193200 pdhA Methylobacterium extorquens DM4 pyruvate dehydrogenase E1 alpha subunit YP_003069046.1 3489555 D 661410 CDS YP_003069047.1 254561952 8195837 3490711..3492159 1 NC_012988.1 catalyzes the oxidative decarboxylation of pyruvate with concomitant acetylation of a lipoic acid-containing dihydrolipoamide acetyltransferase within the complex. The E1 component of the pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase(E2) and lipoamide dehydrogenase; pyruvate dehydrogenase subunit beta 3492159 pdhB 8195837 pdhB Methylobacterium extorquens DM4 pyruvate dehydrogenase subunit beta YP_003069047.1 3490711 D 661410 CDS YP_003069048.1 254561953 8195838 3492170..3492448 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pf : putative factor; hypothetical protein 3492448 8195838 METDI3555 Methylobacterium extorquens DM4 hypothetical protein YP_003069048.1 3492170 D 661410 CDS YP_003069049.1 254561954 8193201 3492482..3493894 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 12634329; Product type e : enzyme; dihydrolipoamide acetyltransferase 3493894 pdhC 8193201 pdhC Methylobacterium extorquens DM4 dihydrolipoamide acetyltransferase YP_003069049.1 3492482 D 661410 CDS YP_003069050.1 254561955 8195839 3494057..3495496 1 NC_012988.1 E3 component of pyruvate complex; catalyzes the oxidation of dihydrolipoamide to lipoamide; dihydrolipoamide dehydrogenase 3495496 lpd 8195839 lpd Methylobacterium extorquens DM4 dihydrolipoamide dehydrogenase YP_003069050.1 3494057 D 661410 CDS YP_003069051.1 254561956 8195645 3495757..3495909 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3495909 8195645 METDI3558 Methylobacterium extorquens DM4 hypothetical protein YP_003069051.1 3495757 D 661410 CDS YP_003069052.1 254561957 8193202 complement(3496005..3496517) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3496517 8193202 METDI3559 Methylobacterium extorquens DM4 hypothetical protein YP_003069052.1 3496005 R 661410 CDS YP_003069053.1 254561958 8193203 complement(3496495..3497229) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3497229 8193203 METDI3560 Methylobacterium extorquens DM4 hypothetical protein YP_003069053.1 3496495 R 661410 CDS YP_003069054.1 254561959 8193204 3497510..3497683 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3497683 8193204 METDI3561 Methylobacterium extorquens DM4 hypothetical protein YP_003069054.1 3497510 D 661410 CDS YP_003069055.1 254561960 8193205 3497771..3498406 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3498406 8193205 METDI3562 Methylobacterium extorquens DM4 hypothetical protein YP_003069055.1 3497771 D 661410 CDS YP_003069056.1 254561961 8193206 complement(3498575..3499921) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 7574579; Product type e : enzyme; sorbosone dehydrogenase precursor (SNDH) 3499921 8193206 METDI3563 Methylobacterium extorquens DM4 sorbosone dehydrogenase precursor (SNDH) YP_003069056.1 3498575 R 661410 CDS YP_003069057.1 254561962 8193207 complement(3499943..3500149) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3500149 8193207 METDI3564 Methylobacterium extorquens DM4 hypothetical protein YP_003069057.1 3499943 R 661410 CDS YP_003069058.1 254561963 8193208 3500360..3501097 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3501097 8193208 METDI3565 Methylobacterium extorquens DM4 hypothetical protein YP_003069058.1 3500360 D 661410 CDS YP_003069059.1 254561964 8193209 3501231..3502250 1 NC_012988.1 catalyzes the radical-mediated insertion of two sulfur atoms into an acyl carrier protein (ACP) bound to an octanoyl group to produce a lipoyl group; lipoyl synthase 3502250 lipA 8193209 lipA Methylobacterium extorquens DM4 lipoyl synthase YP_003069059.1 3501231 D 661410 CDS YP_003069060.1 254561965 8195636 3502305..3502715 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; cyclase/dehydrase 3502715 8195636 METDI3567 Methylobacterium extorquens DM4 cyclase/dehydrase YP_003069060.1 3502305 D 661410 CDS YP_003069061.1 254561966 8193210 complement(3502800..3503225) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcriptional regulator, AsnC/Lrp family 3503225 8193210 METDI3568 Methylobacterium extorquens DM4 putative transcriptional regulator, AsnC/Lrp family YP_003069061.1 3502800 R 661410 CDS YP_003069062.1 254561967 8193211 3503383..3504387 1 NC_012988.1 catalyzes the formation of L-proline from L-ornithine; ornithine cyclodeaminase 3504387 arcB 8193211 arcB Methylobacterium extorquens DM4 ornithine cyclodeaminase YP_003069062.1 3503383 D 661410 CDS YP_003069063.1 254561968 8195081 3504700..3505740 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative 3-oxoacyl-(Acyl-carrier-protein) synthase III 3505740 8195081 METDI3570 Methylobacterium extorquens DM4 putative 3-oxoacyl-(Acyl-carrier-protein) synthase III YP_003069063.1 3504700 D 661410 CDS YP_003069064.1 254561969 8193212 3505760..3505993 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier; putative acyl carrier protein 3505993 8193212 METDI3571 Methylobacterium extorquens DM4 putative acyl carrier protein YP_003069064.1 3505760 D 661410 CDS YP_003069065.1 254561970 8193213 3505994..3507040 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative keto/oxo acyl-ACP synthase 3507040 8193213 METDI3572 Methylobacterium extorquens DM4 putative keto/oxo acyl-ACP synthase YP_003069065.1 3505994 D 661410 CDS YP_003069066.1 254561971 8193214 3507037..3507798 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative short-chain dehydrogenase/reductase SDR 3507798 8193214 METDI3573 Methylobacterium extorquens DM4 putative short-chain dehydrogenase/reductase SDR YP_003069066.1 3507037 D 661410 CDS YP_003069067.1 254561972 8193215 complement(3507727..3508875) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative Naphthalene 1,2-dioxygenase subunit alpha (Naphthalene 1,2-dioxygenase ISP alpha) 3508875 8193215 METDI3574 Methylobacterium extorquens DM4 putative Naphthalene 1,2-dioxygenase subunit alpha (Naphthalene 1,2-dioxygenase ISP alpha) YP_003069067.1 3507727 R 661410 CDS YP_003069068.1 254561973 8193216 3509282..3509932 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative acetyltransferase 3509932 8193216 METDI3575 Methylobacterium extorquens DM4 putative acetyltransferase YP_003069068.1 3509282 D 661410 CDS YP_003069069.1 254561974 8193217 complement(3510123..3512276) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3512276 8193217 METDI3576 Methylobacterium extorquens DM4 hypothetical protein YP_003069069.1 3510123 R 661410 CDS YP_003069070.1 254561975 8193218 complement(3512443..3512781) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3512781 8193218 METDI3577 Methylobacterium extorquens DM4 hypothetical protein YP_003069070.1 3512443 R 661410 CDS YP_003069071.1 254561976 8193219 complement(3512778..3514565) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative ABC transporter, fused ATPase and permease domains 3514565 8193219 METDI3578 Methylobacterium extorquens DM4 putative ABC transporter, fused ATPase and permease domains YP_003069071.1 3512778 R 661410 CDS YP_003069072.1 254561977 8193220 3515455..3515952 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 16377905; Product type e : enzyme; oxidoreductase, 2Fe-2S subunit 3515952 8193220 METDI3581 Methylobacterium extorquens DM4 oxidoreductase, 2Fe-2S subunit YP_003069072.1 3515455 D 661410 CDS YP_003069073.1 254561978 8193221 3515949..3516998 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; oxidoreductase, FAD-binding subunit; putative molybdopterin oxidoreductase, xanthine dehydrogenase family 3516998 8193221 METDI3582 Methylobacterium extorquens DM4 oxidoreductase, FAD-binding subunit; putative molybdopterin oxidoreductase, xanthine dehydrogenase family YP_003069073.1 3515949 D 661410 CDS YP_003069074.1 254561979 8193222 3516991..3519234 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; oxidoreductase, molybdopterin-binding subunit 3519234 8193222 METDI3583 Methylobacterium extorquens DM4 oxidoreductase, molybdopterin-binding subunit YP_003069074.1 3516991 D 661410 CDS YP_003069075.1 254561980 8193223 complement(3519383..3519910) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor; CinA (competence-damaged protein) family protein 3519910 8193223 METDI3584 Methylobacterium extorquens DM4 CinA (competence-damaged protein) family protein YP_003069075.1 3519383 R 661410 CDS YP_003069076.1 254561981 8193224 complement(3519907..3521190) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 10518523, 11427897, 10694574; Product type e : enzyme; IspD/IspF bifunctional enzyme (2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase (MEP cytidylyltransferase, MCT); 2-C-methyl-D-erythritol 2, 4-cyclodiphosphate synthase (MECPS, MECDP synthase)) 3521190 ispDF 8193224 ispDF Methylobacterium extorquens DM4 IspD/IspF bifunctional enzyme (2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase (MEP cytidylyltransferase, MCT); 2-C-methyl-D-erythritol 2, 4-cyclodiphosphate synthase (MECPS, MECDP synthase)) YP_003069076.1 3519907 R 661410 CDS YP_003069077.1 254561982 8195608 3521369..3522397 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 1459953, 1547773, 22095566, 2835774, 2837762, 8226664; Product type e : enzyme; tRNA-dihydrouridine synthase B 3522397 dusB 8195608 dusB Methylobacterium extorquens DM4 tRNA-dihydrouridine synthase B YP_003069077.1 3521369 D 661410 CDS YP_003069078.1 254561983 8195318 3522397..3523530 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; sensory histdine kinase (soluble) in two-component regulatory system with GlnG, nitrogen regulation (nitrogen regulator II, NRII); Domains: HK homodimeric, ATPase and PAS 3523530 glnL 8195318 glnL Methylobacterium extorquens DM4 sensory histdine kinase (soluble) in two-component regulatory system with GlnG, nitrogen regulation (nitrogen regulator II, NRII); Domains: HK homodimeric, ATPase and PAS YP_003069078.1 3522397 D 661410 CDS YP_003069079.1 254561984 8195505 3523541..3525013 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type r : regulator; two-component sigma-54 specific nitrogen transcriptional regulator, Fis subfamily; N-terminal response receiver 3525013 glnG 8195505 glnG Methylobacterium extorquens DM4 two-component sigma-54 specific nitrogen transcriptional regulator, Fis subfamily; N-terminal response receiver YP_003069079.1 3523541 D 661410 CDS YP_003069080.1 254561985 8195501 3525141..3526778 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative helicase domain protein, DEAD/DEAH motif 3526778 8195501 METDI3589 Methylobacterium extorquens DM4 putative helicase domain protein, DEAD/DEAH motif YP_003069080.1 3525141 D 661410 CDS YP_003069081.1 254561986 8193225 3526872..3529241 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; nitrogen regulatory signal transduction histidine kinase NtrY 3529241 ntrY 8193225 ntrY Methylobacterium extorquens DM4 nitrogen regulatory signal transduction histidine kinase NtrY YP_003069081.1 3526872 D 661410 CDS YP_003069082.1 254561987 8195786 3529238..3530608 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type r : regulator; two-component sigma-54 specific nitrogen transcriptional regulator, Fis subfamily; N-terminal response receiver 3530608 glnG 8195786 glnG Methylobacterium extorquens DM4 two-component sigma-54 specific nitrogen transcriptional regulator, Fis subfamily; N-terminal response receiver YP_003069082.1 3529238 D 661410 CDS YP_003069083.1 254561988 8195502 3530916..3531170 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type f : factor; Protein hfq, RNA-binding host factor 3531170 hfq 8195502 hfq Methylobacterium extorquens DM4 Protein hfq, RNA-binding host factor YP_003069083.1 3530916 D 661410 CDS YP_003069084.1 254561989 8195556 3531267..3532682 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 3040675, 8248183; Product type pe : putative enzyme; putative GTPase (HflX) 3532682 8195556 METDI3593 Methylobacterium extorquens DM4 putative GTPase (HflX) YP_003069084.1 3531267 D 661410 CDS YP_003069085.1 254561990 8193226 complement(3532829..3534397) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type t : transporter; Sulphate transporter 3534397 8193226 METDI3594 Methylobacterium extorquens DM4 Sulphate transporter YP_003069085.1 3532829 R 661410 CDS YP_003069086.1 254561991 8193227 complement(3534407..3535162) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 3049588, 91242169, 1740425, 94075239; Product type e : enzyme; carbonic anhydrase 3535162 cynT 8193227 cynT Methylobacterium extorquens DM4 carbonic anhydrase YP_003069086.1 3534407 R 661410 CDS YP_003069087.1 254561992 8195242 complement(3535459..3535770) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3535770 8195242 METDI3596 Methylobacterium extorquens DM4 hypothetical protein YP_003069087.1 3535459 R 661410 CDS YP_003069088.1 254561993 8193228 complement(3535898..3536188) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3536188 8193228 METDI3597 Methylobacterium extorquens DM4 hypothetical protein YP_003069088.1 3535898 R 661410 CDS YP_003069089.1 254561994 8193229 complement(3536612..3536998) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3536998 8193229 METDI3598 Methylobacterium extorquens DM4 hypothetical protein YP_003069089.1 3536612 R 661410 CDS YP_003069090.1 254561995 8193230 complement(3537028..3537405) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3537405 8193230 METDI3599 Methylobacterium extorquens DM4 hypothetical protein YP_003069090.1 3537028 R 661410 CDS YP_003069091.1 254561996 8193231 complement(3537432..3540608) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type t : transporter; Heavy metal efflux pump CzcA (precursor) 3540608 8193231 METDI3600 Methylobacterium extorquens DM4 Heavy metal efflux pump CzcA (precursor) YP_003069091.1 3537432 R 661410 CDS YP_003069092.1 254561997 8193232 complement(3540622..3542352) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3542352 8193232 METDI3601 Methylobacterium extorquens DM4 hypothetical protein YP_003069092.1 3540622 R 661410 CDS YP_003069093.1 254561998 8193233 complement(3542424..3542858) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3542858 8193233 METDI3602 Methylobacterium extorquens DM4 hypothetical protein YP_003069093.1 3542424 R 661410 CDS YP_003069094.1 254561999 8193234 3543439..3543927 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcriptional regulator, MucR family 3543927 8193234 METDI3603 Methylobacterium extorquens DM4 putative transcriptional regulator, MucR family YP_003069094.1 3543439 D 661410 CDS YP_003069095.1 254562000 8193235 3544003..3544563 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3544563 8193235 METDI3604 Methylobacterium extorquens DM4 hypothetical protein YP_003069095.1 3544003 D 661410 CDS YP_003069096.1 254562001 8193236 3544575..3546032 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative MCP methyltransferase, CheR-type 3546032 8193236 METDI3605 Methylobacterium extorquens DM4 putative MCP methyltransferase, CheR-type YP_003069096.1 3544575 D 661410 CDS YP_003069097.1 254562002 8193237 3546029..3546586 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor; cheW-like protein 3546586 8193237 METDI3606 Methylobacterium extorquens DM4 cheW-like protein YP_003069097.1 3546029 D 661410 CDS YP_003069098.1 254562003 8193238 3546667..3548415 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type prc : putative receptor; methyl-accepting chemotaxis sensory transducer 3548415 8193238 METDI3607 Methylobacterium extorquens DM4 methyl-accepting chemotaxis sensory transducer YP_003069098.1 3546667 D 661410 CDS YP_003069099.1 254562004 8193239 3548440..3550686 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type r : regulator; signal transduction histidine kinase with N-terminal phosphotransfer and C-terminal response regulator receiver domains 3550686 8193239 METDI3608 Methylobacterium extorquens DM4 signal transduction histidine kinase with N-terminal phosphotransfer and C-terminal response regulator receiver domains YP_003069099.1 3548440 D 661410 CDS YP_003069100.1 254562005 8193240 3550710..3551768 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 3280143, 3510184, 89053899, 90008896, 93209955, 9687492, 99395068; Product type r : regulator; Chemotaxis response regulator protein-glutamate methylesterase 3551768 cheB 8193240 cheB Methylobacterium extorquens DM4 Chemotaxis response regulator protein-glutamate methylesterase YP_003069100.1 3550710 D 661410 CDS YP_003069101.1 254562006 8195163 3551765..3553498 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor; putative Sensor protein, CheY-like domain 3553498 8195163 METDI3610 Methylobacterium extorquens DM4 putative Sensor protein, CheY-like domain YP_003069101.1 3551765 D 661410 CDS YP_003069102.1 254562007 8193241 3553495..3555363 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative sensor hybrid histidine kinase with two PAS and two response regulator receiver domains 3555363 8193241 METDI3611 Methylobacterium extorquens DM4 putative sensor hybrid histidine kinase with two PAS and two response regulator receiver domains YP_003069102.1 3553495 D 661410 CDS YP_003069103.1 254562008 8193242 complement(3555719..3557029) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; Cytochrome c, class I 3557029 8193242 METDI3612 Methylobacterium extorquens DM4 Cytochrome c, class I YP_003069103.1 3555719 R 661410 CDS YP_003069104.1 254562009 8193243 3557254..3558339 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative molybdopterin biosynthesis-related protein 3558339 8193243 METDI3613 Methylobacterium extorquens DM4 putative molybdopterin biosynthesis-related protein YP_003069104.1 3557254 D 661410 CDS YP_003069105.1 254562010 8193244 3558336..3560312 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative molybdopterin biosynthesis protein MoeA/LysR substrate binding-domain-containing protein 3560312 8193244 METDI3614 Methylobacterium extorquens DM4 putative molybdopterin biosynthesis protein MoeA/LysR substrate binding-domain-containing protein YP_003069105.1 3558336 D 661410 CDS YP_003069106.1 254562011 8193245 3560309..3560845 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; molybdopterin-guanine dinucleotide biosynthesis protein B, GTP-binding 3560845 mobB 8193245 mobB Methylobacterium extorquens DM4 molybdopterin-guanine dinucleotide biosynthesis protein B, GTP-binding YP_003069106.1 3560309 D 661410 CDS YP_003069107.1 254562012 8195708 3560849..3562099 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative molybdopterin biosynthesis-related protein 3562099 8195708 METDI3616 Methylobacterium extorquens DM4 putative molybdopterin biosynthesis-related protein YP_003069107.1 3560849 D 661410 CDS YP_003069108.1 254562013 8193246 complement(3562154..3563194) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative Regulatory protein, LysR 3563194 8193246 METDI3617 Methylobacterium extorquens DM4 putative Regulatory protein, LysR YP_003069108.1 3562154 R 661410 CDS YP_003069109.1 254562014 8193247 3563275..3564015 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative Sulfate/tungstate uptake transporter, membrane component of ABC transporter 3564015 8193247 METDI3618 Methylobacterium extorquens DM4 putative Sulfate/tungstate uptake transporter, membrane component of ABC transporter YP_003069109.1 3563275 D 661410 CDS YP_003069110.1 254562015 8193248 3564012..3564728 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative Phosphate-transporting ATPase, ATP-binding component of ABC transporter 3564728 8193248 METDI3619 Methylobacterium extorquens DM4 putative Phosphate-transporting ATPase, ATP-binding component of ABC transporter YP_003069110.1 3564012 D 661410 CDS YP_003069111.1 254562016 8193249 3564701..3565528 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type t : transporter; Molybdate or tungstate transport precursor 3565528 modB1 8193249 modB1 Methylobacterium extorquens DM4 Molybdate or tungstate transport precursor YP_003069111.1 3564701 D 661410 CDS YP_003069112.1 254562017 8195712 complement(3565697..3565933) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3565933 8195712 METDI3621 Methylobacterium extorquens DM4 hypothetical protein YP_003069112.1 3565697 R 661410 CDS YP_003069113.1 254562018 8193250 complement(3565977..3566621) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3566621 8193250 METDI3622 Methylobacterium extorquens DM4 hypothetical protein YP_003069113.1 3565977 R 661410 CDS YP_003069114.1 254562019 8193251 complement(3566690..3568147) 1 NC_012988.1 involved in the control of the structural glucose backbone of osmoregulated periplasmic glucans; glucan biosynthesis protein D 3568147 mdoD 8193251 mdoD Methylobacterium extorquens DM4 glucan biosynthesis protein D YP_003069114.1 3566690 R 661410 CDS YP_003069115.1 254562020 8193252 3568416..3570332 1 NC_012988.1 necessary for biosynthesis of osmoregulated periplasmic glucans possibly involved in the transfer to the periplasmic space; glucosyltransferase MdoH 3570332 8193252 METDI3624 Methylobacterium extorquens DM4 glucosyltransferase MdoH YP_003069115.1 3568416 D 661410 CDS YP_003069116.1 254562021 8193253 complement(3570422..3570889) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3570889 8193253 METDI3625 Methylobacterium extorquens DM4 hypothetical protein YP_003069116.1 3570422 R 661410 CDS YP_003069117.1 254562022 8193254 complement(3570979..3572196) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15581575, 9843488; Product type e : enzyme; putative cystathionine gamma-synthase, PLP-dependent (metB) 3572196 8193254 METDI3626 Methylobacterium extorquens DM4 putative cystathionine gamma-synthase, PLP-dependent (metB) YP_003069117.1 3570979 R 661410 CDS YP_003069118.1 254562023 8193255 3572294..3572809 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11097914, 7673149; Product type prc : putative receptor; putative tryptophan-rich sensory protein; putative membrane protein; putative regulatory receptor protein 3572809 8193255 METDI3627 Methylobacterium extorquens DM4 putative tryptophan-rich sensory protein; putative membrane protein; putative regulatory receptor protein YP_003069118.1 3572294 D 661410 CDS YP_003069119.1 254562024 8193256 complement(3572970..3573335) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative response regulator (CheY-like protein) 3573335 8193256 METDI3628 Methylobacterium extorquens DM4 putative response regulator (CheY-like protein) YP_003069119.1 3572970 R 661410 CDS YP_003069120.1 254562025 8193257 complement(3573499..3574068) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 12070315; Product type e : enzyme; Hypoxanthine phosphoribosyl transferase 3574068 hpt 8193257 hpt Methylobacterium extorquens DM4 Hypoxanthine phosphoribosyl transferase YP_003069120.1 3573499 R 661410 CDS YP_003069121.1 254562026 8195575 complement(3574257..3575012) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3575012 8195575 METDI3630 Methylobacterium extorquens DM4 hypothetical protein YP_003069121.1 3574257 R 661410 CDS YP_003069122.1 254562027 8193258 3575170..3575883 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type t : transporter; transporter subunit: ATP-binding component of ABC superfamily 3575883 ftsE 8193258 ftsE Methylobacterium extorquens DM4 transporter subunit: ATP-binding component of ABC superfamily YP_003069122.1 3575170 D 661410 CDS YP_003069123.1 254562028 8195449 3575880..3576860 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3576860 8195449 METDI3632 Methylobacterium extorquens DM4 hypothetical protein YP_003069123.1 3575880 D 661410 CDS YP_003069124.1 254562029 8193259 3577102..3577806 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3577806 8193259 METDI3633 Methylobacterium extorquens DM4 hypothetical protein YP_003069124.1 3577102 D 661410 CDS YP_003069125.1 254562030 8193260 complement(3577893..3578267) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative response regulator receiver 3578267 8193260 METDI3634 Methylobacterium extorquens DM4 putative response regulator receiver YP_003069125.1 3577893 R 661410 CDS YP_003069126.1 254562031 8193261 3578540..3579673 1 NC_012988.1 catalyzes the formation of glutamate 5-phosphate from glutamate in proline biosynthesis; gamma-glutamyl kinase 3579673 proB 8193261 proB Methylobacterium extorquens DM4 gamma-glutamyl kinase YP_003069126.1 3578540 D 661410 CDS YP_003069127.1 254562032 8195902 3579813..3581120 1 NC_012988.1 Catalyzes the phosphorylation of L-glutamate during the proline biosynthesis pathway; gamma-glutamyl phosphate reductase 3581120 proA 8195902 proA Methylobacterium extorquens DM4 gamma-glutamyl phosphate reductase YP_003069127.1 3579813 D 661410 CDS YP_003069128.1 254562033 8195901 3581108..3581725 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 15805518; Product type e : enzyme; nicotinate-nucleotide adenylyltransferase (Deamido-NAD(+) pyrophosphorylase) (Deamido-NAD(+) diphosphorylase) (Nicotinate mononucleotide adenylyltransferase) (NaMN adenylyltransferase) 3581725 nadD 8195901 nadD Methylobacterium extorquens DM4 nicotinate-nucleotide adenylyltransferase (Deamido-NAD(+) pyrophosphorylase) (Deamido-NAD(+) diphosphorylase) (Nicotinate mononucleotide adenylyltransferase) (NaMN adenylyltransferase) YP_003069128.1 3581108 D 661410 CDS YP_003069129.1 254562034 8195768 3582168..3582470 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3582470 8195768 METDI3639 Methylobacterium extorquens DM4 hypothetical protein YP_003069129.1 3582168 D 661410 CDS YP_003069130.1 254562035 8193262 complement(3582479..3583174) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3583174 8193262 METDI3640 Methylobacterium extorquens DM4 hypothetical protein YP_003069130.1 3582479 R 661410 CDS YP_003069131.1 254562036 8193263 complement(3583228..3583746) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcriptional regulator 3583746 8193263 METDI3641 Methylobacterium extorquens DM4 putative transcriptional regulator YP_003069131.1 3583228 R 661410 CDS YP_003069132.1 254562037 8193264 complement(3583876..3584916) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 12753898; Product type e : enzyme; Aldose-1-epimerase (Galactose mutarotase) 3584916 galM 8193264 galM Methylobacterium extorquens DM4 Aldose-1-epimerase (Galactose mutarotase) YP_003069132.1 3583876 R 661410 CDS YP_003069133.1 254562038 8195463 complement(3585013..3586806) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative ABC transporter, fused ATPase and transmembrane permease domains 3586806 8195463 METDI3643 Methylobacterium extorquens DM4 putative ABC transporter, fused ATPase and transmembrane permease domains YP_003069133.1 3585013 R 661410 CDS YP_003069134.1 254562039 8193265 3587078..3588007 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative ABC transporter, periplasmic protein 3588007 8193265 METDI3644 Methylobacterium extorquens DM4 putative ABC transporter, periplasmic protein YP_003069134.1 3587078 D 661410 CDS YP_003069135.1 254562040 8193266 complement(3588126..3588377) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; molybdopterin converting factor, subunit 1 3588377 moaD 8193266 moaD Methylobacterium extorquens DM4 molybdopterin converting factor, subunit 1 YP_003069135.1 3588126 R 661410 CDS YP_003069136.1 254562041 8195705 complement(3588432..3589130) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 3003065; Product type e : enzyme; phosphatidylglycerophosphate synthetase 3589130 pgsA 8195705 pgsA Methylobacterium extorquens DM4 phosphatidylglycerophosphate synthetase YP_003069136.1 3588432 R 661410 CDS YP_003069137.1 254562042 8195853 complement(3589117..3591165) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type e : enzyme; DNA exisiton repair enzyme together with UvrAB 3591165 uvrC 8195853 uvrC Methylobacterium extorquens DM4 DNA exisiton repair enzyme together with UvrAB YP_003069137.1 3589117 R 661410 CDS YP_003069138.1 254562043 8196331 complement(3591261..3591986) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3591986 8196331 METDI3648 Methylobacterium extorquens DM4 hypothetical protein YP_003069138.1 3591261 R 661410 CDS YP_003069139.1 254562044 8193267 3592216..3592938 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3592938 8193267 METDI3649 Methylobacterium extorquens DM4 hypothetical protein YP_003069139.1 3592216 D 661410 CDS YP_003069140.1 254562045 8193268 complement(3593018..3593749) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3593749 8193268 METDI3650 Methylobacterium extorquens DM4 hypothetical protein YP_003069140.1 3593018 R 661410 CDS YP_003069141.1 254562046 8193269 complement(3594078..3594950) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; putative 31 kDa outer-membrane immunogenic protein precursor (omp31) 3594950 8193269 METDI3651 Methylobacterium extorquens DM4 putative 31 kDa outer-membrane immunogenic protein precursor (omp31) YP_003069141.1 3594078 R 661410 CDS YP_003069142.1 254562047 8193270 complement(3595347..3596114) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3596114 8193270 METDI3652 Methylobacterium extorquens DM4 hypothetical protein YP_003069142.1 3595347 R 661410 CDS YP_003069143.1 254562048 8193271 complement(3596154..3597239) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3597239 8193271 METDI3653 Methylobacterium extorquens DM4 hypothetical protein YP_003069143.1 3596154 R 661410 CDS YP_003069144.1 254562049 8193272 complement(3597242..3598132) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 94327509; Product type e : enzyme; Prolipoprotein diacylglyceryl transferase 3598132 lgt 8193272 lgt Methylobacterium extorquens DM4 Prolipoprotein diacylglyceryl transferase YP_003069144.1 3597242 R 661410 CDS YP_003069145.1 254562050 8195634 3598274..3598954 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative MgtC family protein 3598954 8195634 METDI3655 Methylobacterium extorquens DM4 putative MgtC family protein YP_003069145.1 3598274 D 661410 CDS YP_003069146.1 254562051 8193273 3599058..3600689 1 NC_012988.1 catalyzes the interconversion of alpha-D-glucose 1-phosphate to alpha-D-glucose 6-phosphate; phosphoglucomutase 3600689 pgm 8193273 pgm Methylobacterium extorquens DM4 phosphoglucomutase YP_003069146.1 3599058 D 661410 CDS YP_003069147.1 254562052 8195851 3600686..3601123 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3601123 8195851 METDI3657 Methylobacterium extorquens DM4 hypothetical protein YP_003069147.1 3600686 D 661410 CDS YP_003069148.1 254562053 8193274 3601087..3601956 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3601956 8193274 METDI3658 Methylobacterium extorquens DM4 hypothetical protein YP_003069148.1 3601087 D 661410 CDS YP_003069149.1 254562054 8193275 complement(3602130..3603035) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative cell wall hydrolase 3603035 8193275 METDI3659 Methylobacterium extorquens DM4 putative cell wall hydrolase YP_003069149.1 3602130 R 661410 CDS YP_003069150.1 254562055 8193276 complement(3603142..3603333) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3603333 8193276 METDI3660 Methylobacterium extorquens DM4 hypothetical protein YP_003069150.1 3603142 R 661410 CDS YP_003069151.1 254562056 8193277 complement(3603586..3606252) 1 NC_012988.1 catalyzes the formation of phosphoenolpyruvate from pyruvate; pyruvate phosphate dikinase 3606252 ppdK 8193277 ppdK Methylobacterium extorquens DM4 pyruvate phosphate dikinase YP_003069151.1 3603586 R 661410 CDS YP_003069152.1 254562057 8195882 complement(3606470..3606622) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3606622 8195882 METDI3662 Methylobacterium extorquens DM4 hypothetical protein YP_003069152.1 3606470 R 661410 CDS YP_003069153.1 254562058 8193278 complement(3606858..3607532) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3607532 8193278 METDI3663 Methylobacterium extorquens DM4 hypothetical protein YP_003069153.1 3606858 R 661410 CDS YP_003069154.1 254562059 8193279 3607719..3608162 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type e : enzyme; lactoylglutathione lyase family protein 3608162 8193279 METDI3664 Methylobacterium extorquens DM4 lactoylglutathione lyase family protein YP_003069154.1 3607719 D 661410 CDS YP_003069155.1 254562060 8193280 3608245..3608505 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 3608505 8193280 METDI3665 Methylobacterium extorquens DM4 hypothetical protein YP_003069155.1 3608245 D 661410 CDS YP_003069156.1 254562061 8193281 complement(3608551..3609000) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3609000 8193281 METDI3666 Methylobacterium extorquens DM4 hypothetical protein YP_003069156.1 3608551 R 661410 CDS YP_003069157.1 254562062 8193282 complement(3609907..3610380) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8022282, 9194707; Product type pr : putative regulator; putative transcriptional regulator, MarR family 3610380 8193282 METDI3667 Methylobacterium extorquens DM4 putative transcriptional regulator, MarR family YP_003069157.1 3609907 R 661410 CDS YP_003069158.1 254562063 8193283 3610505..3611284 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3611284 8193283 METDI3668 Methylobacterium extorquens DM4 hypothetical protein YP_003069158.1 3610505 D 661410 CDS YP_003069159.1 254562064 8193284 complement(3611304..3612236) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3612236 8193284 METDI3669 Methylobacterium extorquens DM4 hypothetical protein YP_003069159.1 3611304 R 661410 CDS YP_003069160.1 254562065 8193285 complement(3612316..3613314) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3613314 8193285 METDI3670 Methylobacterium extorquens DM4 hypothetical protein YP_003069160.1 3612316 R 661410 CDS YP_003069161.1 254562066 8193286 3614047..3614223 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3614223 8193286 METDI3671 Methylobacterium extorquens DM4 hypothetical protein YP_003069161.1 3614047 D 661410 CDS YP_003069162.1 254562067 8193287 complement(3614302..3614550) 1 NC_012988.1 Evidence 1c : Function experimentally demonstrated in the studied genus; Product type f : factor; anti-sigma factor 3614550 nepR 8193287 nepR Methylobacterium extorquens DM4 anti-sigma factor YP_003069162.1 3614302 R 661410 CDS YP_003069163.1 254562068 8195775 3614724..3615506 1 NC_012988.1 in Caulobacter crescentus, CC3477 is differentially expressed in minimal salts media with glucose as compared to complex media; two-component response regulator 3615506 phyR 8195775 phyR Methylobacterium extorquens DM4 two-component response regulator YP_003069163.1 3614724 D 661410 CDS YP_003069164.1 254562069 8195865 3615967..3616329 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3616329 8195865 METDI3674 Methylobacterium extorquens DM4 hypothetical protein YP_003069164.1 3615967 D 661410 CDS YP_003069165.1 254562070 8193288 complement(3616427..3616966) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3616966 8193288 METDI3675 Methylobacterium extorquens DM4 hypothetical protein YP_003069165.1 3616427 R 661410 CDS YP_003069166.1 254562071 8193289 3617089..3618480 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative aminotransferase 3618480 8193289 METDI3676 Methylobacterium extorquens DM4 putative aminotransferase YP_003069166.1 3617089 D 661410 CDS YP_003069167.1 254562072 8193290 3618827..3619042 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3619042 8193290 METDI3677 Methylobacterium extorquens DM4 hypothetical protein YP_003069167.1 3618827 D 661410 CDS YP_003069168.1 254562073 8193291 3619080..3619994 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3619994 8193291 METDI3678 Methylobacterium extorquens DM4 hypothetical protein YP_003069168.1 3619080 D 661410 CDS YP_003069169.1 254562074 8193292 complement(3620010..3620228) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3620228 8193292 METDI3679 Methylobacterium extorquens DM4 hypothetical protein YP_003069169.1 3620010 R 661410 CDS YP_003069170.1 254562075 8193293 complement(3620285..3620722) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative acetyltransferase 3620722 8193293 METDI3680 Methylobacterium extorquens DM4 putative acetyltransferase YP_003069170.1 3620285 R 661410 CDS YP_003069171.1 254562076 8193294 complement(3620719..3621642) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; hypothetical protein 3621642 8193294 METDI3681 Methylobacterium extorquens DM4 hypothetical protein YP_003069171.1 3620719 R 661410 CDS YP_003069172.1 254562077 8193295 complement(3621692..3621979) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3621979 8193295 METDI3682 Methylobacterium extorquens DM4 hypothetical protein YP_003069172.1 3621692 R 661410 CDS YP_003069173.1 254562078 8193296 complement(3622140..3623294) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; Ribonuclease D (RNase D) 3623294 rnd 8193296 rnd Methylobacterium extorquens DM4 Ribonuclease D (RNase D) YP_003069173.1 3622140 R 661410 CDS YP_003069174.1 254562079 8196002 complement(3623390..3623698) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3623698 8196002 METDI3684 Methylobacterium extorquens DM4 hypothetical protein YP_003069174.1 3623390 R 661410 CDS YP_003069175.1 254562080 8193297 3623994..3625205 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative penicillin binding protein, beta-lactamase/transpeptidase-like superfamily 3625205 8193297 METDI3685 Methylobacterium extorquens DM4 putative penicillin binding protein, beta-lactamase/transpeptidase-like superfamily YP_003069175.1 3623994 D 661410 CDS YP_003069176.1 254562081 8193298 complement(3625245..3627143) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3627143 8193298 METDI3686 Methylobacterium extorquens DM4 hypothetical protein YP_003069176.1 3625245 R 661410 CDS YP_003069177.1 254562082 8193299 3627529..3628266 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type e : enzyme; acetyl-CoA:acetoacetyl-CoA transferase, alpha subunit 3628266 atoD 8193299 atoD Methylobacterium extorquens DM4 acetyl-CoA:acetoacetyl-CoA transferase, alpha subunit YP_003069177.1 3627529 D 661410 CDS YP_003069178.1 254562083 8195114 3628375..3629034 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type e : enzyme; acetyl-CoA:acetoacetyl-CoA transferase, beta subunit 3629034 atoA 8195114 atoA Methylobacterium extorquens DM4 acetyl-CoA:acetoacetyl-CoA transferase, beta subunit YP_003069178.1 3628375 D 661410 CDS YP_003069179.1 254562084 8195113 3629206..3629613 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3629613 8195113 METDI3689 Methylobacterium extorquens DM4 hypothetical protein YP_003069179.1 3629206 D 661410 CDS YP_003069180.1 254562085 8193300 3629793..3630161 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3630161 8193300 METDI3690 Methylobacterium extorquens DM4 hypothetical protein YP_003069180.1 3629793 D 661410 CDS YP_003069181.1 254562086 8193301 3630201..3631583 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 8760927; Product type m : membrane component; hypothetical protein 3631583 8193301 METDI3691 Methylobacterium extorquens DM4 hypothetical protein YP_003069181.1 3630201 D 661410 CDS YP_003069182.1 254562087 8193302 3631644..3633974 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type prc : putative receptor; putative TonB-dependent receptor protein precursor 3633974 8193302 METDI3692 Methylobacterium extorquens DM4 putative TonB-dependent receptor protein precursor YP_003069182.1 3631644 D 661410 CDS YP_003069183.1 254562088 8193303 complement(3634055..3635005) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3635005 8193303 METDI3693 Methylobacterium extorquens DM4 hypothetical protein YP_003069183.1 3634055 R 661410 CDS YP_003069184.1 254562089 8193304 complement(3634980..3635795) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12228263; Product type pt : putative transporter; putative ABC transporter, ATPase; putative iron transporter 3635795 8193304 METDI3694 Methylobacterium extorquens DM4 putative ABC transporter, ATPase; putative iron transporter YP_003069184.1 3634980 R 661410 CDS YP_003069185.1 254562090 8193305 complement(3635792..3636832) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative ABC transporter, permease precursor, putative iron transporter 3636832 8193305 METDI3695 Methylobacterium extorquens DM4 putative ABC transporter, permease precursor, putative iron transporter YP_003069185.1 3635792 R 661410 CDS YP_003069186.1 254562091 8193306 complement(3636829..3637662) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative ABC transporter, periplasmic protein; putative iron transporter 3637662 8193306 METDI3696 Methylobacterium extorquens DM4 putative ABC transporter, periplasmic protein; putative iron transporter YP_003069186.1 3636829 R 661410 CDS YP_003069187.1 254562092 8193307 3637827..3638177 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3638177 8193307 METDI3697 Methylobacterium extorquens DM4 hypothetical protein YP_003069187.1 3637827 D 661410 CDS YP_003069188.1 254562093 8193308 3638177..3638602 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3638602 8193308 METDI3698 Methylobacterium extorquens DM4 hypothetical protein YP_003069188.1 3638177 D 661410 CDS YP_003069189.1 254562094 8193309 complement(3638652..3640217) 1 NC_012988.1 contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway; GMP synthase 3640217 guaA 8193309 guaA Methylobacterium extorquens DM4 GMP synthase YP_003069189.1 3638652 R 661410 CDS YP_003069190.1 254562095 8195539 3640387..3640614 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 3640614 8195539 METDI3700 Methylobacterium extorquens DM4 hypothetical protein YP_003069190.1 3640387 D 661410 CDS YP_003069191.1 254562096 8193310 complement(3640800..3641357) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3641357 8193310 METDI3701 Methylobacterium extorquens DM4 hypothetical protein YP_003069191.1 3640800 R 661410 CDS YP_003069192.1 254562097 8193311 complement(3641520..3642548) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12730169; Product type pe : putative enzyme; putative pectin acetylesterase precursor; putative alpha-beta hydrolase precursor 3642548 8193311 METDI3702 Methylobacterium extorquens DM4 putative pectin acetylesterase precursor; putative alpha-beta hydrolase precursor YP_003069192.1 3641520 R 661410 CDS YP_003069193.1 254562098 8193312 complement(3642684..3644033) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative SUN-family protein, RNA methyltransferase 3644033 8193312 METDI3703 Methylobacterium extorquens DM4 putative SUN-family protein, RNA methyltransferase YP_003069193.1 3642684 R 661410 CDS YP_003069194.1 254562099 8193313 3644129..3644317 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3644317 8193313 METDI3704 Methylobacterium extorquens DM4 hypothetical protein YP_003069194.1 3644129 D 661410 CDS YP_003069195.1 254562100 8193314 complement(3644421..3645359) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3645359 8193314 METDI3705 Methylobacterium extorquens DM4 hypothetical protein YP_003069195.1 3644421 R 661410 CDS YP_003069196.1 254562101 8193315 3645566..3646450 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3646450 8193315 METDI3706 Methylobacterium extorquens DM4 hypothetical protein YP_003069196.1 3645566 D 661410 CDS YP_003069197.1 254562102 8193316 3646774..3647619 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3647619 8193316 METDI3707 Methylobacterium extorquens DM4 hypothetical protein YP_003069197.1 3646774 D 661410 CDS YP_003069198.1 254562103 8193317 complement(3648148..3649638) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 2860637; Product type e : enzyme; IMP dehydrogeanse 3649638 guaB 8193317 guaB Methylobacterium extorquens DM4 IMP dehydrogeanse YP_003069198.1 3648148 R 661410 CDS YP_003069199.1 254562104 8195540 complement(3649619..3649822) 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 3649822 8195540 METDI3709 Methylobacterium extorquens DM4 hypothetical protein YP_003069199.1 3649619 R 661410 CDS YP_003069200.1 254562105 8193318 3649902..3651068 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 7830569, 9218774; Product type cp : cell process; Cell division protein 3651068 ftsW 8193318 ftsW Methylobacterium extorquens DM4 Cell division protein YP_003069200.1 3649902 D 661410 CDS YP_003069201.1 254562106 8195455 3651065..3652174 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 10892798, 1387377; Product type e : enzyme; Undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase 3652174 murG 8195455 murG Methylobacterium extorquens DM4 Undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase YP_003069201.1 3651065 D 661410 CDS YP_003069202.1 254562107 8195742 3652316..3653722 1 NC_012988.1 Catalyzes the formation of UDP-N-acetylmuramoyl-L-alanine from UDP-N-acetylmuramate and L-alanine in peptidoglycan synthesis; UDP-N-acetylmuramate--L-alanine ligase 3653722 murC 8195742 murC Methylobacterium extorquens DM4 UDP-N-acetylmuramate--L-alanine ligase YP_003069202.1 3652316 D 661410 CDS YP_003069203.1 254562108 8195738 complement(3653739..3654128) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative phage-related transcriptional regulator 3654128 8195738 METDI3713 Methylobacterium extorquens DM4 putative phage-related transcriptional regulator YP_003069203.1 3653739 R 661410 CDS YP_003069204.1 254562109 8193319 complement(3654139..3654345) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3654345 8193319 METDI3714 Methylobacterium extorquens DM4 hypothetical protein YP_003069204.1 3654139 R 661410 CDS YP_003069205.1 254562110 8193320 3654441..3655370 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 12757953, 14551189, 8448160; Product type e : enzyme; UDP-N-acetylenolpyruvoylglucosamine reductase 3655370 murB 8193320 murB Methylobacterium extorquens DM4 UDP-N-acetylenolpyruvoylglucosamine reductase YP_003069205.1 3654441 D 661410 CDS YP_003069206.1 254562111 8195737 3655414..3656337 1 NC_012988.1 D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli; D-alanine--D-alanine ligase 3656337 ddl 8195737 ddl Methylobacterium extorquens DM4 D-alanine--D-alanine ligase YP_003069206.1 3655414 D 661410 CDS YP_003069207.1 254562112 8195283 3656304..3657242 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 9352931; Product type cp : cell process; putative cell division protein (FtsQ-like) 3657242 8195283 METDI3717 Methylobacterium extorquens DM4 putative cell division protein (FtsQ-like) YP_003069207.1 3656304 D 661410 CDS YP_003069208.1 254562113 8193321 3657368..3658627 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 11847116, 2846985, 2995680, 9352931; Product type cp : cell process; cell division protein FtsA 3658627 ftsA 8193321 ftsA Methylobacterium extorquens DM4 cell division protein FtsA YP_003069208.1 3657368 D 661410 CDS YP_003069209.1 254562114 8195448 3658833..3660590 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 1653222, 9352931; Product type cp : cell process; Cell division GTPase 3660590 ftsZ 8195448 ftsZ Methylobacterium extorquens DM4 Cell division GTPase YP_003069209.1 3658833 D 661410 CDS YP_003069210.1 254562115 8195457 3660941..3661888 1 NC_012988.1 zinc-dependent; catalyzes the deacetylation of UDP-(3-O-acyl)-N-acetylglucosamine to UDP-3-O-(3-hydroxytetradecanoyl)-glucosamine in the second step of lipid A biosynthesis; UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase 3661888 lpxC 8195457 lpxC Methylobacterium extorquens DM4 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase YP_003069210.1 3660941 D 661410 CDS YP_003069211.1 254562116 8195648 3662054..3662929 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8830266; Product type lp : lipoprotein; putative lipoprotein UPF0169; putative exported protein 3662929 8195648 METDI3721 Methylobacterium extorquens DM4 putative lipoprotein UPF0169; putative exported protein YP_003069211.1 3662054 D 661410 CDS YP_003069212.1 254562117 8193322 complement(3663198..3664184) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3664184 8193322 METDI3722 Methylobacterium extorquens DM4 hypothetical protein YP_003069212.1 3663198 R 661410 CDS YP_003069213.1 254562118 8193323 3664340..3666040 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 3037486; Product type cp : cell process; DNA repair protein RecN 3666040 recN 8193323 recN Methylobacterium extorquens DM4 DNA repair protein RecN YP_003069213.1 3664340 D 661410 CDS YP_003069214.1 254562119 8195972 complement(3666037..3666330) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3666330 8195972 METDI3724 Methylobacterium extorquens DM4 hypothetical protein YP_003069214.1 3666037 R 661410 CDS YP_003069215.1 254562120 8193324 complement(3666414..3666686) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3666686 8193324 METDI3725 Methylobacterium extorquens DM4 hypothetical protein YP_003069215.1 3666414 R 661410 CDS YP_003069216.1 254562121 8193325 complement(3666718..3667410) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3667410 8193325 METDI3726 Methylobacterium extorquens DM4 hypothetical protein YP_003069216.1 3666718 R 661410 CDS YP_003069217.1 254562122 8193326 complement(3667552..3669867) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type e : enzyme; putative molybdopterin oxidoreductase 3669867 8193326 METDI3727 Methylobacterium extorquens DM4 putative molybdopterin oxidoreductase YP_003069217.1 3667552 R 661410 CDS YP_003069218.1 254562123 8193327 complement(3669970..3671046) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3671046 8193327 METDI3728 Methylobacterium extorquens DM4 hypothetical protein YP_003069218.1 3669970 R 661410 CDS YP_003069219.1 254562124 8193328 3671392..3673311 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 9061015; Product type f : factor; Chaperone protein DnaK 3673311 dnaK 8193328 dnaK Methylobacterium extorquens DM4 Chaperone protein DnaK YP_003069219.1 3671392 D 661410 CDS YP_003069220.1 254562125 8195308 3673509..3674720 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type f : factor; heat shock protein (Hsp40), co-chaperone with DnaK 3674720 dnaJ 8195308 dnaJ Methylobacterium extorquens DM4 heat shock protein (Hsp40), co-chaperone with DnaK YP_003069220.1 3673509 D 661410 CDS YP_003069221.1 254562126 8195307 3674879..3675535 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; Phospholipid N-methyltransferase 3675535 pmtA 8195307 pmtA Methylobacterium extorquens DM4 Phospholipid N-methyltransferase YP_003069221.1 3674879 D 661410 CDS YP_003069222.1 254562127 8195868 3675783..3676127 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3676127 8195868 METDI3732 Methylobacterium extorquens DM4 hypothetical protein YP_003069222.1 3675783 D 661410 CDS YP_003069223.1 254562128 8193329 complement(3676155..3677465) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 6286410, 6323164; Product type e : enzyme; thymidine phosphorylase 3677465 deoA 8193329 deoA Methylobacterium extorquens DM4 thymidine phosphorylase YP_003069223.1 3676155 R 661410 CDS YP_003069224.1 254562129 8195286 complement(3677462..3678235) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 11598300; Product type e : enzyme; 2-deoxyribose-5-phosphate aldolase, NAD(P)-linked 3678235 deoC 8195286 deoC Methylobacterium extorquens DM4 2-deoxyribose-5-phosphate aldolase, NAD(P)-linked YP_003069224.1 3677462 R 661410 CDS YP_003069225.1 254562130 8195288 complement(3678245..3679057) 1 NC_012988.1 catalyzes the formation of a purine and ribose phosphate from a purine nucleoside; in E. coli this enzyme functions in xanthosine degradation; purine nucleoside phosphorylase 3679057 xapA 8195288 xapA Methylobacterium extorquens DM4 purine nucleoside phosphorylase YP_003069225.1 3678245 R 661410 CDS YP_003069226.1 254562131 8196336 complement(3679047..3679460) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 15689149; Product type e : enzyme; cytidine deaminase (cytidine aminohydrolase) 3679460 cdd 8196336 cdd Methylobacterium extorquens DM4 cytidine deaminase (cytidine aminohydrolase) YP_003069226.1 3679047 R 661410 CDS YP_003069227.1 254562132 8195159 3679606..3679830 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3679830 8195159 METDI3737 Methylobacterium extorquens DM4 hypothetical protein YP_003069227.1 3679606 D 661410 CDS YP_003069228.1 254562133 8193330 complement(3679913..3680896) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 9268317; Product type e : enzyme; Tetraacyldisaccharide 4'-kinase 3680896 lpxK 8193330 lpxK Methylobacterium extorquens DM4 Tetraacyldisaccharide 4'-kinase YP_003069228.1 3679913 R 661410 CDS YP_003069229.1 254562134 8195650 complement(3680904..3682208) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 2033061; Product type e : enzyme; putative 3-deoxy-D-manno-octulosonic-acid transferase (KDO transferase encoded by kdtA) 3682208 8195650 METDI3739 Methylobacterium extorquens DM4 putative 3-deoxy-D-manno-octulosonic-acid transferase (KDO transferase encoded by kdtA) YP_003069229.1 3680904 R 661410 CDS YP_003069230.1 254562135 8193331 complement(3682205..3682954) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3682954 8193331 METDI3740 Methylobacterium extorquens DM4 hypothetical protein YP_003069230.1 3682205 R 661410 CDS YP_003069231.1 254562136 8193332 3683191..3684138 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative metallophosphatase/metallophosphoesterase 3684138 8193332 METDI3741 Methylobacterium extorquens DM4 putative metallophosphatase/metallophosphoesterase YP_003069231.1 3683191 D 661410 CDS YP_003069232.1 254562137 8193333 complement(3684154..3684630) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type r : regulator; response regulator receiver 3684630 8193333 METDI3742 Methylobacterium extorquens DM4 response regulator receiver YP_003069232.1 3684154 R 661410 CDS YP_003069233.1 254562138 8193334 3685012..3685848 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcriptional regulator, cold shock protein 3685848 8193334 METDI3744 Methylobacterium extorquens DM4 putative transcriptional regulator, cold shock protein YP_003069233.1 3685012 D 661410 CDS YP_003069234.1 254562139 8193335 3685977..3686222 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3686222 8193335 METDI3745 Methylobacterium extorquens DM4 hypothetical protein YP_003069234.1 3685977 D 661410 CDS YP_003069235.1 254562140 8193336 complement(3686251..3687660) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; leucine aminopeptidase 3687660 8193336 METDI3746 Methylobacterium extorquens DM4 leucine aminopeptidase YP_003069235.1 3686251 R 661410 CDS YP_003069236.1 254562141 8193337 3687758..3688606 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3688606 8193337 METDI3747 Methylobacterium extorquens DM4 hypothetical protein YP_003069236.1 3687758 D 661410 CDS YP_003069237.1 254562142 8193338 3688792..3689097 1 NC_012988.1 required for 70S ribosome assembly; 50S ribosomal protein L28 3689097 rpmB 8193338 rpmB Methylobacterium extorquens DM4 50S ribosomal protein L28 YP_003069237.1 3688792 D 661410 CDS YP_003069238.1 254562143 8196036 3689210..3690139 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative permease 3690139 8196036 METDI3749 Methylobacterium extorquens DM4 putative permease YP_003069238.1 3689210 D 661410 CDS YP_003069239.1 254562144 8193339 3690248..3691996 1 NC_012988.1 class I; LysRS1; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in Methanosarcina barkeri this enzyme charges both tRNA molecules for lysine that exist in this organism (but the tRNALysUUU very poorly) and in the presence of LysRS2 can charge tRNAPyl with lysine; lysyl-tRNA synthetase 3691996 lysK 8193339 lysK Methylobacterium extorquens DM4 lysyl-tRNA synthetase YP_003069239.1 3690248 D 661410 CDS YP_003069240.1 254562145 8195657 complement(3692143..3692637) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3692637 8195657 METDI3751 Methylobacterium extorquens DM4 hypothetical protein YP_003069240.1 3692143 R 661410 CDS YP_003069241.1 254562146 8193340 3692877..3693842 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type f : factor; peptide chain release factor RF-2 3693842 prfB 8193340 prfB Methylobacterium extorquens DM4 peptide chain release factor RF-2 YP_003069241.1 3692877 D 661410 CDS YP_003069242.1 254562147 8195895 complement(3693987..3695165) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative peptidase precursor 3695165 8195895 METDI3753 Methylobacterium extorquens DM4 putative peptidase precursor YP_003069242.1 3693987 R 661410 CDS YP_003069243.1 254562148 8193341 complement(3695340..3695807) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative thiol peroxidase, putative peroxiredoxin 3695807 8193341 METDI3754 Methylobacterium extorquens DM4 putative thiol peroxidase, putative peroxiredoxin YP_003069243.1 3695340 R 661410 CDS YP_003069244.1 254562149 8193342 3695958..3699413 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3699413 8193342 METDI3755 Methylobacterium extorquens DM4 hypothetical protein YP_003069244.1 3695958 D 661410 CDS YP_003069245.1 254562150 8193343 3700011..3701087 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 9555904; Product type pe : putative enzyme; putative fatty acid desaturase ; putative membrane protein 3701087 8193343 METDI3756 Methylobacterium extorquens DM4 putative fatty acid desaturase ; putative membrane protein YP_003069245.1 3700011 D 661410 CDS YP_003069246.1 254562151 8193344 complement(3701150..3702421) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; tyrosine tRNA synthetase 3702421 tyrS 8193344 tyrS Methylobacterium extorquens DM4 tyrosine tRNA synthetase YP_003069246.1 3701150 R 661410 CDS YP_003069247.1 254562152 8196292 3702562..3703695 1 NC_012988.1 catalyzes hydrolysis of 1,6-anhydro bond of anyhydro-N-acetylmuramic acid (anhMurNAc) and phosphorylates anhMurNAc to produce N-acetyl-muramate-6-phosphate; involved in murein recycling; anhydro-N-acetylmuramic acid kinase 3703695 anmK 8196292 anmK Methylobacterium extorquens DM4 anhydro-N-acetylmuramic acid kinase YP_003069247.1 3702562 D 661410 CDS YP_003069248.1 254562153 8193345 3703692..3704309 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3704309 8193345 METDI3759 Methylobacterium extorquens DM4 hypothetical protein YP_003069248.1 3703692 D 661410 CDS YP_003069249.1 254562154 8193346 complement(3704303..3704617) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcriptional regulator 3704617 8193346 METDI3760 Methylobacterium extorquens DM4 putative transcriptional regulator YP_003069249.1 3704303 R 661410 CDS YP_003069250.1 254562155 8193347 3704694..3705794 1 NC_012988.1 catalyzes the formation of chorismate from 5-O-(1-carboxyvinyl)-3-phosphoshikimate in aromatic amino acid biosynthesis; chorismate synthase 3705794 aroC 8193347 aroC Methylobacterium extorquens DM4 chorismate synthase YP_003069250.1 3704694 D 661410 CDS YP_003069251.1 254562156 8195093 3705923..3707002 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; 3,4-dihydroxy-2-butanone-4-phoshate synthase/GTP cyclohydrolase II 3707002 ribAB 8195093 ribAB Methylobacterium extorquens DM4 3,4-dihydroxy-2-butanone-4-phoshate synthase/GTP cyclohydrolase II YP_003069251.1 3705923 D 661410 CDS YP_003069252.1 254562157 8195992 3707214..3707342 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3707342 8195992 METDI3763 Methylobacterium extorquens DM4 hypothetical protein YP_003069252.1 3707214 D 661410 CDS YP_003069253.1 254562158 8193348 complement(3707367..3708218) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; Histone deacetylase family protein 3708218 8193348 METDI3764 Methylobacterium extorquens DM4 Histone deacetylase family protein YP_003069253.1 3707367 R 661410 CDS YP_003069254.1 254562159 8193349 3708597..3709235 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3709235 8193349 METDI3765 Methylobacterium extorquens DM4 hypothetical protein YP_003069254.1 3708597 D 661410 CDS YP_003069255.1 254562160 8193350 3709408..3709866 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3709866 8193350 METDI3766 Methylobacterium extorquens DM4 hypothetical protein YP_003069255.1 3709408 D 661410 CDS YP_003069256.1 254562161 8193351 3710094..3712097 1 NC_012988.1 Evidence 1c : Function experimentally demonstrated in the studied genus; PubMedId : 12730156, 15188393, 16926146; Product type e : enzyme; propionyl-CoA carboxylase alpha subunit 3712097 pccA 8193351 pccA Methylobacterium extorquens DM4 propionyl-CoA carboxylase alpha subunit YP_003069256.1 3710094 D 661410 CDS YP_003069257.1 254562162 8195832 3712286..3712717 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3712717 8195832 METDI3768 Methylobacterium extorquens DM4 hypothetical protein YP_003069257.1 3712286 D 661410 CDS YP_003069258.1 254562163 8193352 3712756..3712938 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3712938 8193352 METDI3769 Methylobacterium extorquens DM4 hypothetical protein YP_003069258.1 3712756 D 661410 CDS YP_003069259.1 254562164 8193353 3712991..3713275 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 15159579, 15213401; Product type e : enzyme; Acylphosphatase (Acylphosphate phosphohydrolase) 3713275 acyP 8193353 acyP Methylobacterium extorquens DM4 Acylphosphatase (Acylphosphate phosphohydrolase) YP_003069259.1 3712991 D 661410 CDS YP_003069260.1 254562165 8195061 3713377..3714090 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3714090 8195061 METDI3771 Methylobacterium extorquens DM4 hypothetical protein YP_003069260.1 3713377 D 661410 CDS YP_003069261.1 254562166 8193354 3714080..3714343 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3714343 8193354 METDI3772 Methylobacterium extorquens DM4 hypothetical protein YP_003069261.1 3714080 D 661410 CDS YP_003069262.1 254562167 8193355 complement(3714351..3715148) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3715148 8193355 METDI3773 Methylobacterium extorquens DM4 hypothetical protein YP_003069262.1 3714351 R 661410 CDS YP_003069263.1 254562168 8193356 complement(3715210..3715833) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative glutathione S-transferase 3715833 8193356 METDI3774 Methylobacterium extorquens DM4 putative glutathione S-transferase YP_003069263.1 3715210 R 661410 CDS YP_003069264.1 254562169 8193357 complement(3715830..3716891) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10629195, 16166264, 2019591; Product type pe : putative enzyme; putative aminomutase, putative homologue kamA and yjeK 3716891 8193357 METDI3775 Methylobacterium extorquens DM4 putative aminomutase, putative homologue kamA and yjeK YP_003069264.1 3715830 R 661410 CDS YP_003069265.1 254562170 8193358 complement(3716888..3717946) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative lysyl-tRNA synthetase (poxA-like) 3717946 8193358 METDI3776 Methylobacterium extorquens DM4 putative lysyl-tRNA synthetase (poxA-like) YP_003069265.1 3716888 R 661410 CDS YP_003069266.1 254562171 8193359 3718076..3718636 1 NC_012988.1 Involved in peptide bond synthesis; alters the affinity of the ribosome for aminoacyl-tRNA; elongation factor P 3718636 efp 8193359 efp Methylobacterium extorquens DM4 elongation factor P YP_003069266.1 3718076 D 661410 CDS YP_003069267.1 254562172 8195327 complement(3718812..3719798) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3719798 8195327 METDI3778 Methylobacterium extorquens DM4 hypothetical protein YP_003069267.1 3718812 R 661410 CDS YP_003069268.1 254562173 8193360 3720221..3720766 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative tandem cold-shock DNA-binding domain protein 3720766 8193360 METDI3779 Methylobacterium extorquens DM4 putative tandem cold-shock DNA-binding domain protein YP_003069268.1 3720221 D 661410 CDS YP_003069269.1 254562174 8193361 3720763..3721293 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3721293 8193361 METDI3780 Methylobacterium extorquens DM4 hypothetical protein YP_003069269.1 3720763 D 661410 CDS YP_003069270.1 254562175 8193362 3721299..3723047 1 NC_012988.1 involved in chelation of magnesium into protoporphyrin IX; involved in bacteriochlorophyll biosynthesis; part of a complex with BchI, BchD, and BchH; magnesium chelatase subunit D 3723047 bchD 8193362 bchD Methylobacterium extorquens DM4 magnesium chelatase subunit D YP_003069270.1 3721299 D 661410 CDS YP_003069271.1 254562176 8195127 3723062..3723961 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative alpha/beta hydrolase, putative magnesium chelatase accessory protein 3723961 8195127 METDI3782 Methylobacterium extorquens DM4 putative alpha/beta hydrolase, putative magnesium chelatase accessory protein YP_003069271.1 3723062 D 661410 CDS YP_003069272.1 254562177 8193363 3724006..3725532 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 10648776, 7721699, 8021167; Product type e : enzyme; phytoene dehydrogenase (phytoene desaturase) 3725532 crtI 8193363 crtI Methylobacterium extorquens DM4 phytoene dehydrogenase (phytoene desaturase) YP_003069272.1 3724006 D 661410 CDS YP_003069273.1 254562178 8195220 3725513..3726574 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 10648776, 7721699, 8021167; Product type e : enzyme; phytoene synthase 3726574 crtB 8195220 crtB Methylobacterium extorquens DM4 phytoene synthase YP_003069273.1 3725513 D 661410 CDS YP_003069274.1 254562179 8195216 complement(3726651..3727265) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 2211515; Product type f : factor; urease accessory protein UreG 3727265 ureG 8195216 ureG Methylobacterium extorquens DM4 urease accessory protein UreG YP_003069274.1 3726651 R 661410 CDS YP_003069275.1 254562180 8196327 complement(3727281..3728027) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 2211515; Product type f : factor; urease accessory protein UreF 3728027 ureF 8196327 ureF Methylobacterium extorquens DM4 urease accessory protein UreF YP_003069275.1 3727281 R 661410 CDS YP_003069276.1 254562181 8196323 complement(3727960..3728451) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 11591723, 2211515, 8318889; Product type f : factor; urease accessory protein UreE 3728451 ureE 8196323 ureE Methylobacterium extorquens DM4 urease accessory protein UreE YP_003069276.1 3727960 R 661410 CDS YP_003069277.1 254562182 8196320 complement(3728456..3728941) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3728941 8196320 METDI3788 Methylobacterium extorquens DM4 hypothetical protein YP_003069277.1 3728456 R 661410 CDS YP_003069278.1 254562183 8193364 complement(3728974..3730701) 1 NC_012988.1 ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 ureC (alpha) and 3 ureAB (gamma/beta) subunits; urease subunit alpha 3730701 ureC 8193364 ureC Methylobacterium extorquens DM4 urease subunit alpha YP_003069278.1 3728974 R 661410 CDS YP_003069279.1 254562184 8196315 complement(3730704..3731264) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3731264 8196315 METDI3790 Methylobacterium extorquens DM4 hypothetical protein YP_003069279.1 3730704 R 661410 CDS YP_003069280.1 254562185 8193365 complement(3731261..3731881) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 10844692, 1452359, 2001995, 2188975, 2318539, 2326167, 9252185; Product type e : enzyme; urease gamma (N-terminal) and beta (C-terminal) subunits (urea amidohydrolase gamma/beta subunits) 3731881 ureAB 8193365 ureAB Methylobacterium extorquens DM4 urease gamma (N-terminal) and beta (C-terminal) subunits (urea amidohydrolase gamma/beta subunits) YP_003069280.1 3731261 R 661410 CDS YP_003069281.1 254562186 8196310 complement(3731962..3732891) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 7813887; Product type f : factor; urease accessory protein D 3732891 ureD 8196310 ureD Methylobacterium extorquens DM4 urease accessory protein D YP_003069281.1 3731962 R 661410 CDS YP_003069282.1 254562187 8196318 3733101..3733619 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type e : enzyme; flavin:NADH oxidoreductase, putative alternative pyrimidine degradation enzyme 3733619 8196318 METDI3793 Methylobacterium extorquens DM4 flavin:NADH oxidoreductase, putative alternative pyrimidine degradation enzyme YP_003069282.1 3733101 D 661410 CDS YP_003069283.1 254562188 8193366 complement(3733778..3734026) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3734026 8193366 METDI3794 Methylobacterium extorquens DM4 hypothetical protein YP_003069283.1 3733778 R 661410 CDS YP_003069284.1 254562189 8193367 3734285..3734641 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3734641 8193367 METDI3795 Methylobacterium extorquens DM4 hypothetical protein YP_003069284.1 3734285 D 661410 CDS YP_003069285.1 254562190 8193368 complement(3734644..3736002) 1 NC_012988.1 catalyzes the transformation of hydroxyatrazine to N-isopropylammelide and ethylamine in the atrazine degradation pathway.; hydroxydechloroatrazine ethylaminohydrolase 3736002 8193368 METDI3796 Methylobacterium extorquens DM4 hydroxydechloroatrazine ethylaminohydrolase YP_003069285.1 3734644 R 661410 CDS YP_003069286.1 254562191 8193369 3736382..3737002 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3737002 8193369 METDI3797 Methylobacterium extorquens DM4 hypothetical protein YP_003069286.1 3736382 D 661410 CDS YP_003069287.1 254562192 8193370 complement(3737079..3737312) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3737312 8193370 METDI3798 Methylobacterium extorquens DM4 hypothetical protein YP_003069287.1 3737079 R 661410 CDS YP_003069288.1 254562193 8193371 3737856..3738869 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 9765575; Product type e : enzyme; UDP-glucuronate 5'-epimerase (UDP-glucuronic acid epimerase) 3738869 lspL 8193371 lspL Methylobacterium extorquens DM4 UDP-glucuronate 5'-epimerase (UDP-glucuronic acid epimerase) YP_003069288.1 3737856 D 661410 CDS YP_003069289.1 254562194 8195654 3739102..3740418 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 9765575; Product type e : enzyme; UDP-glucose-6-dehydrogenase 3740418 ugdH 8195654 ugdH Methylobacterium extorquens DM4 UDP-glucose-6-dehydrogenase YP_003069289.1 3739102 D 661410 CDS YP_003069290.1 254562195 8196298 complement(3740473..3740895) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3740895 8196298 METDI3801 Methylobacterium extorquens DM4 hypothetical protein YP_003069290.1 3740473 R 661410 CDS YP_003069292.1 254562197 8193373 3741374..3741601 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3741601 8193373 METDI3803 Methylobacterium extorquens DM4 hypothetical protein YP_003069292.1 3741374 D 661410 CDS YP_003069293.1 254562198 8193374 3741912..3742184 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3742184 8193374 METDI3805 Methylobacterium extorquens DM4 hypothetical protein YP_003069293.1 3741912 D 661410 CDS YP_003069294.1 254562199 8193375 complement(3742255..3743787) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type e : enzyme; threonine deaminase 3743787 ilvA 8193375 ilvA Methylobacterium extorquens DM4 threonine deaminase YP_003069294.1 3742255 R 661410 CDS YP_003069295.1 254562200 8195592 complement(3743888..3744463) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3744463 8195592 METDI3807 Methylobacterium extorquens DM4 hypothetical protein YP_003069295.1 3743888 R 661410 CDS YP_003069296.1 254562201 8193376 3744472..3744675 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3744675 8193376 METDI3808 Methylobacterium extorquens DM4 hypothetical protein YP_003069296.1 3744472 D 661410 CDS YP_003069297.1 254562202 8193377 3744902..3745120 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3745120 8193377 METDI3809 Methylobacterium extorquens DM4 hypothetical protein YP_003069297.1 3744902 D 661410 CDS YP_003069298.1 254562203 8193378 3745174..3745470 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3745470 8193378 METDI3810 Methylobacterium extorquens DM4 hypothetical protein YP_003069298.1 3745174 D 661410 CDS YP_003069299.1 254562204 8193379 complement(3745492..3745911) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type f : factor; DnaK suppressor protein 3745911 dksA 8193379 dksA Methylobacterium extorquens DM4 DnaK suppressor protein YP_003069299.1 3745492 R 661410 CDS YP_003069300.1 254562205 8195298 complement(3745938..3746150) 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 3746150 8195298 METDI3812 Methylobacterium extorquens DM4 hypothetical protein YP_003069300.1 3745938 R 661410 CDS YP_003069301.1 254562206 8193380 complement(3746165..3747184) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3747184 8193380 METDI3813 Methylobacterium extorquens DM4 hypothetical protein YP_003069301.1 3746165 R 661410 CDS YP_003069302.1 254562207 8193381 complement(3747186..3748559) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative alginate o-acetyltransferase AlgI 3748559 8193381 METDI3814 Methylobacterium extorquens DM4 putative alginate o-acetyltransferase AlgI YP_003069302.1 3747186 R 661410 CDS YP_003069303.1 254562208 8193382 3748930..3749226 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3749226 8193382 METDI3815 Methylobacterium extorquens DM4 hypothetical protein YP_003069303.1 3748930 D 661410 CDS YP_003069304.1 254562209 8193383 complement(3749271..3749711) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 9555902; Product type f : factor; putative Flagellar assembly protein fliX 3749711 8193383 METDI3816 Methylobacterium extorquens DM4 putative Flagellar assembly protein fliX YP_003069304.1 3749271 R 661410 CDS YP_003069305.1 254562210 8193384 3749965..3751107 1 NC_012988.1 part of the basal body which consists of four rings L, P, S, and M mounted on a central rod; Vibrio parahaemolyticus, Yersinia, Bradyrhizobium and other bacteria have two copies of this and other flagellar genes; the V. parahaemolyticus protein is associated with the polar flagella and the Bradyrhizobium protein is associated with the thick flagellum; flagellar basal body P-ring protein 3751107 flgI 8193384 flgI Methylobacterium extorquens DM4 flagellar basal body P-ring protein YP_003069305.1 3749965 D 661410 CDS YP_003069306.1 254562211 8195405 3751134..3751493 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3751493 8195405 METDI3818 Methylobacterium extorquens DM4 hypothetical protein YP_003069306.1 3751134 D 661410 CDS YP_003069307.1 254562212 8193385 3751483..3751962 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3751962 8193385 METDI3819 Methylobacterium extorquens DM4 hypothetical protein YP_003069307.1 3751483 D 661410 CDS YP_003069308.1 254562213 8193386 3752301..3752477 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3752477 8193386 METDI3820 Methylobacterium extorquens DM4 hypothetical protein YP_003069308.1 3752301 D 661410 CDS YP_003069309.1 254562214 8193387 complement(3752703..3753455) 1 NC_012988.1 part of the flagellar basal body which consists of four rings L,P, S and M mounted on a central rod; flagellar basal body L-ring protein 3753455 flgH 8193387 flgH Methylobacterium extorquens DM4 flagellar basal body L-ring protein YP_003069309.1 3752703 R 661410 CDS YP_003069310.1 254562215 8195403 complement(3753512..3754558) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type s : structure; Flageller protein FlgA 3754558 flgA 8195403 flgA Methylobacterium extorquens DM4 Flageller protein FlgA YP_003069310.1 3753512 R 661410 CDS YP_003069311.1 254562216 8195390 complement(3754573..3755364) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type s : structure; flagellar biosynthesis; cell-distal portion of basal-body rod 3755364 flgG 8195390 flgG Methylobacterium extorquens DM4 flagellar biosynthesis; cell-distal portion of basal-body rod YP_003069311.1 3754573 R 661410 CDS YP_003069312.1 254562217 8195401 complement(3755391..3756131) 1 NC_012988.1 FlgF, with FlgB and C, makes up the proximal portion of the flagellar basal body rod; Bradyrhizobium has one thick flagellum and several thin flagella; the Bradyrhizobium protein in this cluster is associated with the thick flagellum; flagellar basal body rod protein FlgF 3756131 flgF 8195401 flgF Methylobacterium extorquens DM4 flagellar basal body rod protein FlgF YP_003069312.1 3755391 R 661410 CDS YP_003069313.1 254562218 8195399 3756405..3756923 1 NC_012988.1 interacts with the cytoplasmic MS ring of the basal body and may act to stabilize the MotAB complexes which surround the MS ring; flagellar basal body-associated protein FliL 3756923 fliL 8195399 fliL Methylobacterium extorquens DM4 flagellar basal body-associated protein FliL YP_003069313.1 3756405 D 661410 CDS YP_003069314.1 254562219 8195422 3757003..3758223 1 NC_012988.1 with FliG and FliN makes up the switch complex which is involved in switching the direction of the flagella rotation; Bradyrhizobium has one thick flagellum and several thin flagella; the protein in this cluster is associated with the thick flagellum; flagellar motor switch protein FliM 3758223 fliM 8195422 fliM Methylobacterium extorquens DM4 flagellar motor switch protein FliM YP_003069314.1 3757003 D 661410 CDS YP_003069315.1 254562220 8195424 3758237..3758725 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3758725 8195424 METDI3827 Methylobacterium extorquens DM4 hypothetical protein YP_003069315.1 3758237 D 661410 CDS YP_003069316.1 254562221 8193388 3758722..3759519 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3759519 8193388 METDI3828 Methylobacterium extorquens DM4 hypothetical protein YP_003069316.1 3758722 D 661410 CDS YP_003069317.1 254562222 8193389 complement(3759523..3760017) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 2671656, 3528129, 89364713; Product type pe : putative enzyme; putative Glutathione peroxidase 3760017 8193389 METDI3829 Methylobacterium extorquens DM4 putative Glutathione peroxidase YP_003069317.1 3759523 R 661410 CDS YP_003069318.1 254562223 8193390 3760348..3761037 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3761037 8193390 METDI3830 Methylobacterium extorquens DM4 hypothetical protein YP_003069318.1 3760348 D 661410 CDS YP_003069319.1 254562224 8193391 3761084..3762325 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative membrane bound lytic murein transglycosylase B, mltB 3762325 8193391 METDI3831 Methylobacterium extorquens DM4 putative membrane bound lytic murein transglycosylase B, mltB YP_003069319.1 3761084 D 661410 CDS YP_003069320.1 254562225 8193392 3762332..3762913 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative NAD(P)H quinone oxidoreductasease 3762913 8193392 METDI3832 Methylobacterium extorquens DM4 putative NAD(P)H quinone oxidoreductasease YP_003069320.1 3762332 D 661410 CDS YP_003069321.1 254562226 8193393 complement(3762953..3763837) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor; hypothetical protein 3763837 8193393 METDI3833 Methylobacterium extorquens DM4 hypothetical protein YP_003069321.1 3762953 R 661410 CDS YP_003069322.1 254562227 8193394 complement(3764066..3764461) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3764461 8193394 METDI3834 Methylobacterium extorquens DM4 hypothetical protein YP_003069322.1 3764066 R 661410 CDS YP_003069323.1 254562228 8193395 complement(3764666..3766009) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 10482502, 4568614; Product type t : transporter; citrate and C4-dicarboxylic acids transport protein (DAACS family) 3766009 dctA 8193395 dctA Methylobacterium extorquens DM4 citrate and C4-dicarboxylic acids transport protein (DAACS family) YP_003069323.1 3764666 R 661410 CDS YP_003069324.1 254562229 8195280 3766321..3768198 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type prc : putative receptor; putative sensor histidine kinase, putative transcriptional regulator of C4 dicarboxylate transporter 3768198 8195280 METDI3836 Methylobacterium extorquens DM4 putative sensor histidine kinase, putative transcriptional regulator of C4 dicarboxylate transporter YP_003069324.1 3766321 D 661410 CDS YP_003069325.1 254562230 8193396 3768195..3769547 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 2134335, 2793824; Product type r : regulator; two-component DctB-like sigma-54 specific transcriptional regulator, Fis subfamily; with N-terminal response regulator receiver and ATPase domains 3769547 8193396 METDI3837 Methylobacterium extorquens DM4 two-component DctB-like sigma-54 specific transcriptional regulator, Fis subfamily; with N-terminal response regulator receiver and ATPase domains YP_003069325.1 3768195 D 661410 CDS YP_003069326.1 254562231 8193397 complement(3769561..3770619) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative diguanylate cyclase (GGDEF motif) 3770619 8193397 METDI3838 Methylobacterium extorquens DM4 putative diguanylate cyclase (GGDEF motif) YP_003069326.1 3769561 R 661410 CDS YP_003069327.1 254562232 8193398 complement(3770874..3773885) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type prc : putative receptor; putative diguanylate cyclase (GGDEF) /phosphodiesterase (EAL), with GAF and two PAS/PAC sensor domains 3773885 8193398 METDI3839 Methylobacterium extorquens DM4 putative diguanylate cyclase (GGDEF) /phosphodiesterase (EAL), with GAF and two PAS/PAC sensor domains YP_003069327.1 3770874 R 661410 CDS YP_003069328.1 254562233 8193399 complement(3774304..3775776) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 14704707; Product type e : enzyme; Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B (Asp/Glu-ADT subunit B) 3775776 gatB 8193399 gatB Methylobacterium extorquens DM4 Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B (Asp/Glu-ADT subunit B) YP_003069328.1 3774304 R 661410 CDS YP_003069329.1 254562234 8195470 complement(3775891..3776061) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3776061 8195470 METDI3841 Methylobacterium extorquens DM4 hypothetical protein YP_003069329.1 3775891 R 661410 CDS YP_003069330.1 254562235 8193400 complement(3776093..3776980) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative cation efflux pump fieF 3776980 8193400 METDI3842 Methylobacterium extorquens DM4 putative cation efflux pump fieF YP_003069330.1 3776093 R 661410 CDS YP_003069331.1 254562236 8193401 complement(3777054..3777317) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3777317 8193401 METDI3843 Methylobacterium extorquens DM4 hypothetical protein YP_003069331.1 3777054 R 661410 CDS YP_003069332.1 254562237 8193402 complement(3777350..3777598) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3777598 8193402 METDI3844 Methylobacterium extorquens DM4 hypothetical protein YP_003069332.1 3777350 R 661410 CDS YP_003069333.1 254562238 8193403 complement(3777682..3779142) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative Monooxygenase, FAD-binding 3779142 8193403 METDI3845 Methylobacterium extorquens DM4 putative Monooxygenase, FAD-binding YP_003069333.1 3777682 R 661410 CDS YP_003069334.1 254562239 8193404 3779235..3780341 1 NC_012988.1 Synthesizes oQ from preQ1 in a single S-adenosylmethionine-requiring step; S-adenosylmethionine:tRNA ribosyltransferase-isomerase 3780341 queA 8193404 queA Methylobacterium extorquens DM4 S-adenosylmethionine:tRNA ribosyltransferase-isomerase YP_003069334.1 3779235 D 661410 CDS YP_003069335.1 254562240 8195956 3780338..3781180 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3781180 8195956 METDI3847 Methylobacterium extorquens DM4 hypothetical protein YP_003069335.1 3780338 D 661410 CDS YP_003069336.1 254562241 8193405 3781177..3782328 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 11751936, 1706703, 2170107, 7507921, 7893665, 89155457, 92165719, 9714557; Product type e : enzyme; Queuine tRNA-ribosyltransferase (tRNA-guanine transglycosylase) (Guanine insertion enzyme) 3782328 tgt 8193405 tgt Methylobacterium extorquens DM4 Queuine tRNA-ribosyltransferase (tRNA-guanine transglycosylase) (Guanine insertion enzyme) YP_003069336.1 3781177 D 661410 CDS YP_003069337.1 254562242 8196184 complement(3782352..3782609) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3782609 8196184 METDI3849 Methylobacterium extorquens DM4 hypothetical protein YP_003069337.1 3782352 R 661410 CDS YP_003069338.1 254562243 8193406 complement(3782811..3783878) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3783878 8193406 METDI3850 Methylobacterium extorquens DM4 hypothetical protein YP_003069338.1 3782811 R 661410 CDS YP_003069339.1 254562244 8196237 3786035..3787369 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3787369 8196237 METDI3851 Methylobacterium extorquens DM4 hypothetical protein YP_003069339.1 3786035 D 661410 CDS YP_003069340.1 254562245 8193408 3787469..3789007 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3789007 8193408 METDI3852 Methylobacterium extorquens DM4 hypothetical protein YP_003069340.1 3787469 D 661410 CDS YP_003069341.1 254562246 8193409 3789130..3789636 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3789636 8193409 METDI3853 Methylobacterium extorquens DM4 hypothetical protein YP_003069341.1 3789130 D 661410 CDS YP_003069342.1 254562247 8193410 complement(3789646..3790527) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type f : factor; RNA polymerase sigma factor 3790527 8193410 METDI3854 Methylobacterium extorquens DM4 RNA polymerase sigma factor YP_003069342.1 3789646 R 661410 CDS YP_003069343.1 254562248 8193411 complement(3790517..3790981) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3790981 8193411 METDI3855 Methylobacterium extorquens DM4 hypothetical protein YP_003069343.1 3790517 R 661410 CDS YP_003069344.1 254562249 8193412 complement(3791015..3791449) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3791449 8193412 METDI3856 Methylobacterium extorquens DM4 hypothetical protein YP_003069344.1 3791015 R 661410 CDS YP_003069345.1 254562250 8193413 3791644..3793371 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; Adenylate/guanylate cyclase 3793371 cyaA 8193413 cyaA Methylobacterium extorquens DM4 Adenylate/guanylate cyclase YP_003069345.1 3791644 D 661410 CDS YP_003069346.1 254562251 8195233 complement(3793380..3794201) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 1368608, 15213385, 7704276; Product type e : enzyme; arylesterase (alpha/beta hydrolase fold), putative haloperoxidase 3794201 8195233 METDI3858 Methylobacterium extorquens DM4 arylesterase (alpha/beta hydrolase fold), putative haloperoxidase YP_003069346.1 3793380 R 661410 CDS YP_003069347.1 254562252 8193414 complement(3794270..3795457) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 15188393, 16926146; hypothetical protein 3795457 8193414 METDI3859 Methylobacterium extorquens DM4 hypothetical protein YP_003069347.1 3794270 R 661410 CDS YP_003069348.1 254562253 8193415 complement(3795548..3796390) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3796390 8193415 METDI3860 Methylobacterium extorquens DM4 hypothetical protein YP_003069348.1 3795548 R 661410 CDS YP_003069349.1 254562254 8193416 complement(3796397..3796642) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3796642 8193416 METDI3861 Methylobacterium extorquens DM4 hypothetical protein YP_003069349.1 3796397 R 661410 CDS YP_003069350.1 254562255 8193417 3796844..3797086 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 3797086 8193417 METDI3862 Methylobacterium extorquens DM4 hypothetical protein YP_003069350.1 3796844 D 661410 CDS YP_003069351.1 254562256 8193418 complement(3797166..3799298) 1 NC_012988.1 pyrophosphate-energized proton pump; pyrophosphate-energized inorganic pyrophosphatase; H+-PPase; can cleave pyrophosphate to two phosphates; can generate a proton motive force and drive pyrophosphate synthesis when PMF is sufficient; membrane-bound proton-translocating pyrophosphatase 3799298 hppA 8193418 hppA Methylobacterium extorquens DM4 membrane-bound proton-translocating pyrophosphatase YP_003069351.1 3797166 R 661410 CDS YP_003069352.1 254562257 8195573 3799586..3799834 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3799834 8195573 METDI3864 Methylobacterium extorquens DM4 hypothetical protein YP_003069352.1 3799586 D 661410 CDS YP_003069353.1 254562258 8193419 complement(3800125..3800472) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3800472 8193419 METDI3865 Methylobacterium extorquens DM4 hypothetical protein YP_003069353.1 3800125 R 661410 CDS YP_003069354.1 254562259 8193420 complement(3800685..3800900) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3800900 8193420 METDI3866 Methylobacterium extorquens DM4 hypothetical protein YP_003069354.1 3800685 R 661410 CDS YP_003069355.1 254562260 8193421 complement(3801108..3802328) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; aminotransferase 3802328 8193421 METDI3867 Methylobacterium extorquens DM4 aminotransferase YP_003069355.1 3801108 R 661410 CDS YP_003069356.1 254562261 8193422 complement(3802474..3802839) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3802839 8193422 METDI3868 Methylobacterium extorquens DM4 hypothetical protein YP_003069356.1 3802474 R 661410 CDS YP_003069357.1 254562262 8193423 3802967..3804784 1 NC_012988.1 Evidence 1c : Function experimentally demonstrated in the studied genus; PubMedId : 7763712; Product type e : enzyme; Poly(3-hydroxyalkanoate) polymerase (PHA polymerase) (PHA synthase) (Polyhydroxyalkanoic acid synthase) 3804784 phaC 8193423 phaC Methylobacterium extorquens DM4 Poly(3-hydroxyalkanoate) polymerase (PHA polymerase) (PHA synthase) (Polyhydroxyalkanoic acid synthase) YP_003069357.1 3802967 D 661410 CDS YP_003069358.1 254562263 8195856 3804910..3806727 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative monovalent cation:proton antiporter (CPA2 family) ybaL 3806727 8195856 METDI3870 Methylobacterium extorquens DM4 putative monovalent cation:proton antiporter (CPA2 family) ybaL YP_003069358.1 3804910 D 661410 CDS YP_003069359.1 254562264 8193424 complement(3806740..3807867) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative Regulatory protein, LuxR 3807867 8193424 METDI3871 Methylobacterium extorquens DM4 putative Regulatory protein, LuxR YP_003069359.1 3806740 R 661410 CDS YP_003069360.1 254562265 8193425 complement(3808182..3810272) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; glycine tRNA synthetase, beta subunit 3810272 glyS 8193425 glyS Methylobacterium extorquens DM4 glycine tRNA synthetase, beta subunit YP_003069360.1 3808182 R 661410 CDS YP_003069361.1 254562266 8195521 complement(3810428..3812314) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3812314 8195521 METDI3873 Methylobacterium extorquens DM4 hypothetical protein YP_003069361.1 3810428 R 661410 CDS YP_003069362.1 254562267 8193426 complement(3812509..3812952) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3812952 8193426 METDI3874 Methylobacterium extorquens DM4 hypothetical protein YP_003069362.1 3812509 R 661410 CDS YP_003069363.1 254562268 8193427 complement(3812954..3813892) 1 NC_012988.1 glycine--tRNA ligase alpha chain; GlyRS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA; glycyl-tRNA synthetase subunit alpha 3813892 glyQ 8193427 glyQ Methylobacterium extorquens DM4 glycyl-tRNA synthetase subunit alpha YP_003069363.1 3812954 R 661410 CDS YP_003069364.1 254562269 8195520 complement(3813988..3814170) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3814170 8195520 METDI3876 Methylobacterium extorquens DM4 hypothetical protein YP_003069364.1 3813988 R 661410 CDS YP_003069365.1 254562270 8193428 3814397..3814639 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3814639 8193428 METDI3877 Methylobacterium extorquens DM4 hypothetical protein YP_003069365.1 3814397 D 661410 CDS YP_003069366.1 254562271 8193429 complement(3814652..3815215) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type r : regulator; transcriptional regulator, TetR family 3815215 8193429 METDI3878 Methylobacterium extorquens DM4 transcriptional regulator, TetR family YP_003069366.1 3814652 R 661410 CDS YP_003069367.1 254562272 8193430 complement(3815219..3815683) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3815683 8193430 METDI3879 Methylobacterium extorquens DM4 hypothetical protein YP_003069367.1 3815219 R 661410 CDS YP_003069368.1 254562273 8193431 3815968..3816978 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3816978 8193431 METDI3880 Methylobacterium extorquens DM4 hypothetical protein YP_003069368.1 3815968 D 661410 CDS YP_003069369.1 254562274 8193432 complement(3817094..3817954) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; protease SohB, belong to MEROPS peptidase family S49 (protease IV family, clan S-) 3817954 sohB 8193432 sohB Methylobacterium extorquens DM4 protease SohB, belong to MEROPS peptidase family S49 (protease IV family, clan S-) YP_003069369.1 3817094 R 661410 CDS YP_003069370.1 254562275 8196121 complement(3818179..3818931) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative methyltransferase small 3818931 8196121 METDI3882 Methylobacterium extorquens DM4 putative methyltransferase small YP_003069370.1 3818179 R 661410 CDS YP_003069371.1 254562276 8193433 complement(3818932..3819159) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3819159 8193433 METDI3883 Methylobacterium extorquens DM4 hypothetical protein YP_003069371.1 3818932 R 661410 CDS YP_003069372.1 254562277 8193434 3819354..3820376 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 2670911, 8037730, 8312607, 94311902, 97284515; Product type e : enzyme; octaprenyl diphosphate synthase 3820376 ispB 8193434 ispB Methylobacterium extorquens DM4 octaprenyl diphosphate synthase YP_003069372.1 3819354 D 661410 CDS YP_003069373.1 254562278 8195607 complement(3820398..3821273) 1 NC_012988.1 An essential enzyme in the nonmevalonate pathway of isopentenyl diphosphate and dimethylallyl diphosphate biosynthesis; 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase 3821273 ispE 8195607 ispE Methylobacterium extorquens DM4 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase YP_003069373.1 3820398 R 661410 CDS YP_003069374.1 254562279 8193435 3822284..3822709 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; transposase of ISMex15, IS5 family (ORF 1) 3822709 8193435 METDI3887 Methylobacterium extorquens DM4 transposase of ISMex15, IS5 family (ORF 1) YP_003069374.1 3822284 D 661410 CDS YP_003069375.1 254562280 8193436 3822484..3823038 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; transposase of ISMex15, IS5 family (ORF 2) 3823038 8193436 METDI3888 Methylobacterium extorquens DM4 transposase of ISMex15, IS5 family (ORF 2) YP_003069375.1 3822484 D 661410 CDS YP_003069376.1 254562281 8193438 complement(3824383..3824565) 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 3824565 8193438 METDI3890 Methylobacterium extorquens DM4 hypothetical protein YP_003069376.1 3824383 R 661410 CDS YP_003069377.1 254562282 8193439 complement(3824825..3826720) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3826720 8193439 METDI3891 Methylobacterium extorquens DM4 hypothetical protein YP_003069377.1 3824825 R 661410 CDS YP_003069378.1 254562283 8193440 complement(3826853..3827149) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3827149 8193440 METDI3892 Methylobacterium extorquens DM4 hypothetical protein YP_003069378.1 3826853 R 661410 CDS YP_003069379.1 254562284 8193441 complement(3827221..3827433) 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 3827433 8193441 METDI3893 Methylobacterium extorquens DM4 hypothetical protein YP_003069379.1 3827221 R 661410 CDS YP_003069380.1 254562285 8193442 3827840..3828079 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3828079 8193442 METDI3894 Methylobacterium extorquens DM4 hypothetical protein YP_003069380.1 3827840 D 661410 CDS YP_003069381.1 254562286 8193443 3828226..3828549 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3828549 8193443 METDI3895 Methylobacterium extorquens DM4 hypothetical protein YP_003069381.1 3828226 D 661410 CDS YP_003069382.1 254562287 8193446 3830100..3831068 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; putative integral membrane protein, putative Band 7 protein 3831068 8193446 METDI3899 Methylobacterium extorquens DM4 putative integral membrane protein, putative Band 7 protein YP_003069382.1 3830100 D 661410 CDS YP_003069383.1 254562288 8193447 3831281..3832951 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative ABC transporter, fused permease and ATPase subunits 3832951 8193447 METDI3900 Methylobacterium extorquens DM4 putative ABC transporter, fused permease and ATPase subunits YP_003069383.1 3831281 D 661410 CDS YP_003069384.1 254562289 8193448 3833057..3833332 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3833332 8193448 METDI3901 Methylobacterium extorquens DM4 hypothetical protein YP_003069384.1 3833057 D 661410 CDS YP_003069385.1 254562290 8193449 3833329..3833730 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3833730 8193449 METDI3902 Methylobacterium extorquens DM4 hypothetical protein YP_003069385.1 3833329 D 661410 CDS YP_003069386.1 254562291 8193450 complement(3833798..3835855) 1 NC_012988.1 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling; DNA topoisomerase IV subunit B 3835855 parE 8193450 parE Methylobacterium extorquens DM4 DNA topoisomerase IV subunit B YP_003069386.1 3833798 R 661410 CDS YP_003069387.1 254562292 8195829 3836209..3836400 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 3836400 8195829 METDI3904 Methylobacterium extorquens DM4 hypothetical protein YP_003069387.1 3836209 D 661410 CDS YP_003069388.1 254562293 8193451 complement(3836424..3837464) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 9464392; Product type e : enzyme; Low-specificity L-threonine aldolase (Low-specificity L-TA) 3837464 ltaE 8193451 ltaE Methylobacterium extorquens DM4 Low-specificity L-threonine aldolase (Low-specificity L-TA) YP_003069388.1 3836424 R 661410 CDS YP_003069389.1 254562294 8195655 complement(3837606..3839372) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative ABC transporter, fused ATPase and permease domains 3839372 8195655 METDI3906 Methylobacterium extorquens DM4 putative ABC transporter, fused ATPase and permease domains YP_003069389.1 3837606 R 661410 CDS YP_003069390.1 254562295 8193452 complement(3839578..3840933) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type t : transporter; Major facilitator superfamily MFS_1 3840933 8193452 METDI3907 Methylobacterium extorquens DM4 Major facilitator superfamily MFS_1 YP_003069390.1 3839578 R 661410 CDS YP_003069391.1 254562296 8193453 complement(3840930..3841712) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3841712 8193453 METDI3908 Methylobacterium extorquens DM4 hypothetical protein YP_003069391.1 3840930 R 661410 CDS YP_003069392.1 254562297 8193454 3841917..3842291 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3842291 8193454 METDI3909 Methylobacterium extorquens DM4 hypothetical protein YP_003069392.1 3841917 D 661410 CDS YP_003069393.1 254562298 8193455 complement(3842327..3842767) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3842767 8193455 METDI3910 Methylobacterium extorquens DM4 hypothetical protein YP_003069393.1 3842327 R 661410 CDS YP_003069394.1 254562299 8193456 3843088..3843420 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3843420 8193456 METDI3911 Methylobacterium extorquens DM4 hypothetical protein YP_003069394.1 3843088 D 661410 CDS YP_003069395.1 254562300 8193457 complement(3843510..3844301) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; Short-chain dehydrogenase/reductase SDR 3844301 8193457 METDI3912 Methylobacterium extorquens DM4 Short-chain dehydrogenase/reductase SDR YP_003069395.1 3843510 R 661410 CDS YP_003069396.1 254562301 8193458 complement(3844384..3845763) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative transporter, major facilitator superfamily 3845763 8193458 METDI3913 Methylobacterium extorquens DM4 putative transporter, major facilitator superfamily YP_003069396.1 3844384 R 661410 CDS YP_003069397.1 254562302 8193459 3845992..3847011 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8344527; Product type pe : putative enzyme; putative alpha/beta hydrolase precursor 3847011 8193459 METDI3914 Methylobacterium extorquens DM4 putative alpha/beta hydrolase precursor YP_003069397.1 3845992 D 661410 CDS YP_003069398.1 254562303 8193460 3847094..3847960 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15188393, 16926146, 9772162; Product type pe : putative enzyme; putative NAD-binding dehydrogenase, putative 2-hydroxy-3-oxopropionate reductase 3847960 8193460 METDI3915 Methylobacterium extorquens DM4 putative NAD-binding dehydrogenase, putative 2-hydroxy-3-oxopropionate reductase YP_003069398.1 3847094 D 661410 CDS YP_003069399.1 254562304 8193461 complement(3847964..3848671) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative glutathione S-transferase 3848671 8193461 METDI3916 Methylobacterium extorquens DM4 putative glutathione S-transferase YP_003069399.1 3847964 R 661410 CDS YP_003069400.1 254562305 8193462 3848945..3849160 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3849160 8193462 METDI3917 Methylobacterium extorquens DM4 hypothetical protein YP_003069400.1 3848945 D 661410 CDS YP_003069401.1 254562306 8196252 3849317..3849628 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative NADH dehydrogenase (ubiquinone) Fe-S protein 4 (18kD) (NADH-coenzyme Q reductase) (nduFs4) (partial) 3849628 8196252 METDI3918 Methylobacterium extorquens DM4 putative NADH dehydrogenase (ubiquinone) Fe-S protein 4 (18kD) (NADH-coenzyme Q reductase) (nduFs4) (partial) YP_003069401.1 3849317 D 661410 CDS YP_003069402.1 254562307 8193464 complement(3849694..3850155) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 11101664, 15180998; Product type e : enzyme; Guanine deaminase (Guanase) (Guanine aminase) (Guanine aminohydrolase) (GAH) (GDEase) 3850155 guaD 8193464 guaD Methylobacterium extorquens DM4 Guanine deaminase (Guanase) (Guanine aminase) (Guanine aminohydrolase) (GAH) (GDEase) YP_003069402.1 3849694 R 661410 CDS YP_003069403.1 254562308 8195542 complement(3850170..3851234) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3851234 8195542 METDI3920 Methylobacterium extorquens DM4 hypothetical protein YP_003069403.1 3850170 R 661410 CDS YP_003069404.1 254562309 8193465 complement(3851294..3852085) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3852085 8193465 METDI3921 Methylobacterium extorquens DM4 hypothetical protein YP_003069404.1 3851294 R 661410 CDS YP_003069405.1 254562310 8193466 3852312..3854588 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 2975249; Product type e : enzyme; glycogen debranching enzyme 3854588 glgX 8193466 glgX Methylobacterium extorquens DM4 glycogen debranching enzyme YP_003069405.1 3852312 D 661410 CDS YP_003069406.1 254562311 8195493 3854761..3856362 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; histidine kinase 3856362 8195493 METDI3923 Methylobacterium extorquens DM4 histidine kinase YP_003069406.1 3854761 D 661410 CDS YP_003069407.1 254562312 8193467 complement(3856759..3857973) 1 NC_012988.1 Converts isocitrate to alpha ketoglutarate; isocitrate dehydrogenase 3857973 icd 8193467 icd Methylobacterium extorquens DM4 isocitrate dehydrogenase YP_003069407.1 3856759 R 661410 CDS YP_003069408.1 254562313 8195588 complement(3858118..3858630) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3858630 8195588 METDI3926 Methylobacterium extorquens DM4 hypothetical protein YP_003069408.1 3858118 R 661410 CDS YP_003069409.1 254562314 8193468 3858813..3859361 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; formaldehyde activating enzyme homolog 3859361 fae 8193468 fae Methylobacterium extorquens DM4 formaldehyde activating enzyme homolog YP_003069409.1 3858813 D 661410 CDS YP_003069410.1 254562315 8195355 3859468..3859728 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pcp : putative cell process; putative addiction module antidote protein, CopG/Arc/MetJ family 3859728 8195355 METDI3928 Methylobacterium extorquens DM4 putative addiction module antidote protein, CopG/Arc/MetJ family YP_003069410.1 3859468 D 661410 CDS YP_003069411.1 254562316 8193470 complement(3859855..3860409) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; transposase of ISMex15, IS5 family (ORF 2) 3860409 8193470 METDI3930 Methylobacterium extorquens DM4 transposase of ISMex15, IS5 family (ORF 2) YP_003069411.1 3859855 R 661410 CDS YP_003069412.1 254562317 8193471 complement(3860184..3860609) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; transposase of ISMex15, IS5 family (ORF 1) 3860609 8193471 METDI3931 Methylobacterium extorquens DM4 transposase of ISMex15, IS5 family (ORF 1) YP_003069412.1 3860184 R 661410 CDS YP_003069413.1 254562318 8193472 3860887..3861624 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; tRNA/rRNA methyltransferase 3861624 8193472 METDI3932 Methylobacterium extorquens DM4 tRNA/rRNA methyltransferase YP_003069413.1 3860887 D 661410 CDS YP_003069414.1 254562319 8193473 complement(3861628..3861969) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3861969 8193473 METDI3933 Methylobacterium extorquens DM4 hypothetical protein YP_003069414.1 3861628 R 661410 CDS YP_003069415.1 254562320 8193474 complement(3861999..3863012) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 1735726; Product type pe : putative enzyme; putative alcohol dehydrogenase 3863012 8193474 METDI3934 Methylobacterium extorquens DM4 putative alcohol dehydrogenase YP_003069415.1 3861999 R 661410 CDS YP_003069416.1 254562321 8193475 complement(3863145..3864830) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type rc : receptor; methyl-accepting chemotaxis receptor transducer precursor 3864830 8193475 METDI3935 Methylobacterium extorquens DM4 methyl-accepting chemotaxis receptor transducer precursor YP_003069416.1 3863145 R 661410 CDS YP_003069417.1 254562322 8193476 complement(3865328..3865876) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3865876 8193476 METDI3936 Methylobacterium extorquens DM4 hypothetical protein YP_003069417.1 3865328 R 661410 CDS YP_003069418.1 254562323 8193477 complement(3865884..3867191) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 11566369, 12951250; Product type e : enzyme; trans-sulfuration enzyme (O-acetylhomoserine aminocarboxypropyltransferase) 3867191 metY-4 8193477 metY-4 Methylobacterium extorquens DM4 trans-sulfuration enzyme (O-acetylhomoserine aminocarboxypropyltransferase) YP_003069418.1 3865884 R 661410 CDS YP_003069419.1 254562324 8195691 complement(3867335..3867721) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative response regulator receiver (CheY-like protein) 3867721 8195691 METDI3938 Methylobacterium extorquens DM4 putative response regulator receiver (CheY-like protein) YP_003069419.1 3867335 R 661410 CDS YP_003069420.1 254562325 8193478 complement(3867835..3869232) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type c : carrier; glycolate oxidase iron-sulfur subunit 3869232 glcF 8193478 glcF Methylobacterium extorquens DM4 glycolate oxidase iron-sulfur subunit YP_003069420.1 3867835 R 661410 CDS YP_003069421.1 254562326 8195487 complement(3869388..3869756) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3869756 8195487 METDI3940 Methylobacterium extorquens DM4 hypothetical protein YP_003069421.1 3869388 R 661410 CDS YP_003069422.1 254562327 8193479 3869964..3870914 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative lipase/esterase 3870914 8193479 METDI3941 Methylobacterium extorquens DM4 putative lipase/esterase YP_003069422.1 3869964 D 661410 CDS YP_003069423.1 254562328 8193480 3870954..3873464 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; ATP-dependent DNA helicase 3873464 8193480 METDI3942 Methylobacterium extorquens DM4 ATP-dependent DNA helicase YP_003069423.1 3870954 D 661410 CDS YP_003069424.1 254562329 8193481 3873506..3874219 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3874219 8193481 METDI3943 Methylobacterium extorquens DM4 hypothetical protein YP_003069424.1 3873506 D 661410 CDS YP_003069425.1 254562330 8193482 complement(3874333..3874770) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3874770 8193482 METDI3944 Methylobacterium extorquens DM4 hypothetical protein YP_003069425.1 3874333 R 661410 CDS YP_003069426.1 254562331 8193483 3875072..3876397 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative chloride channel protein 3876397 8193483 METDI3945 Methylobacterium extorquens DM4 putative chloride channel protein YP_003069426.1 3875072 D 661410 CDS YP_003069427.1 254562332 8193484 3876471..3876650 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3876650 8193484 METDI3946 Methylobacterium extorquens DM4 hypothetical protein YP_003069427.1 3876471 D 661410 CDS YP_003069428.1 254562333 8193485 3876666..3877511 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative short-chain dehydrogenase/reductase SDR 3877511 8193485 METDI3947 Methylobacterium extorquens DM4 putative short-chain dehydrogenase/reductase SDR YP_003069428.1 3876666 D 661410 CDS YP_003069429.1 254562334 8193486 complement(3877626..3878603) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; thiamin-monophosphate kinase 3878603 thiL 8193486 thiL Methylobacterium extorquens DM4 thiamin-monophosphate kinase YP_003069429.1 3877626 R 661410 CDS YP_003069430.1 254562335 8196190 complement(3878609..3879124) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 12597275; Product type f : factor; transcription antitermination factor 3879124 nusB 8196190 nusB Methylobacterium extorquens DM4 transcription antitermination factor YP_003069430.1 3878609 R 661410 CDS YP_003069431.1 254562336 8195802 complement(3879121..3879642) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 14704707; Product type e : enzyme; 6,7-dimethyl-8-ribityllumazine synthase (DMRL synthase) (Lumazine synthase) (Riboflavin synthase beta chain) 3879642 ribE 8195802 ribE Methylobacterium extorquens DM4 6,7-dimethyl-8-ribityllumazine synthase (DMRL synthase) (Lumazine synthase) (Riboflavin synthase beta chain) YP_003069431.1 3879121 R 661410 CDS YP_003069432.1 254562337 8195994 3879954..3881480 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; hypothetical protein 3881480 8195994 METDI3951 Methylobacterium extorquens DM4 hypothetical protein YP_003069432.1 3879954 D 661410 CDS YP_003069433.1 254562338 8193487 3881480..3881905 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; putative GtrA-like protein 3881905 8193487 METDI3952 Methylobacterium extorquens DM4 putative GtrA-like protein YP_003069433.1 3881480 D 661410 CDS YP_003069434.1 254562339 8193488 complement(3881893..3883113) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3883113 8193488 METDI3953 Methylobacterium extorquens DM4 hypothetical protein YP_003069434.1 3881893 R 661410 CDS YP_003069435.1 254562340 8193489 3883407..3883928 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3883928 8193489 METDI3954 Methylobacterium extorquens DM4 hypothetical protein YP_003069435.1 3883407 D 661410 CDS YP_003069436.1 254562341 8193490 complement(3883942..3884580) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; riboflavin synthase, alpha subunit 3884580 ribE 8193490 ribE Methylobacterium extorquens DM4 riboflavin synthase, alpha subunit YP_003069436.1 3883942 R 661410 CDS YP_003069437.1 254562342 8195995 complement(3884582..3885712) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; fused diaminohydroxyphosphoribosylaminopyrimidine deaminase; 5-amino-6-(5-phosphoribosylamino) uracil reductase 3885712 ribD 8195995 ribD Methylobacterium extorquens DM4 fused diaminohydroxyphosphoribosylaminopyrimidine deaminase; 5-amino-6-(5-phosphoribosylamino) uracil reductase YP_003069437.1 3884582 R 661410 CDS YP_003069438.1 254562343 8195993 complement(3885709..3886266) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type r : regulator; transcriptional regulator NrdR 3886266 nrdR 8195993 nrdR Methylobacterium extorquens DM4 transcriptional regulator NrdR YP_003069438.1 3885709 R 661410 CDS YP_003069439.1 254562344 8193491 complement(3886348..3886800) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcriptional regulator, Rrf2 family 3886800 8193491 METDI3958 Methylobacterium extorquens DM4 putative transcriptional regulator, Rrf2 family YP_003069439.1 3886348 R 661410 CDS YP_003069440.1 254562345 8193492 complement(3887054..3888358) 1 NC_012988.1 catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate; serine hydroxymethyltransferase 3888358 glyA 8193492 glyA Methylobacterium extorquens DM4 serine hydroxymethyltransferase YP_003069440.1 3887054 R 661410 CDS YP_003069441.1 254562346 8195519 complement(3888725..3889213) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative F0F1 ATP synthase, subunit b (atpF) 3889213 8195519 METDI3960 Methylobacterium extorquens DM4 putative F0F1 ATP synthase, subunit b (atpF) YP_003069441.1 3888725 R 661410 CDS YP_003069442.1 254562347 8193493 complement(3889301..3889906) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative F0F1 ATP synthase, subunit b (atpF) 3889906 8193493 METDI3961 Methylobacterium extorquens DM4 putative F0F1 ATP synthase, subunit b (atpF) YP_003069442.1 3889301 R 661410 CDS YP_003069443.1 254562348 8193494 complement(3890104..3890331) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; ATP synthase F0 sector subunit c 3890331 atpE 8193494 atpE Methylobacterium extorquens DM4 ATP synthase F0 sector subunit c YP_003069443.1 3890104 R 661410 CDS YP_003069444.1 254562349 8195120 complement(3890392..3891147) 1 NC_012988.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit A is part of the membrane proton channel F0; F0F1 ATP synthase subunit A 3891147 atpB 8195120 atpB Methylobacterium extorquens DM4 F0F1 ATP synthase subunit A YP_003069444.1 3890392 R 661410 CDS YP_003069445.1 254562350 8195117 complement(3891268..3891636) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative FoF1 ATP synthase, subunit I (atpI) 3891636 8195117 METDI3964 Methylobacterium extorquens DM4 putative FoF1 ATP synthase, subunit I (atpI) YP_003069445.1 3891268 R 661410 CDS YP_003069446.1 254562351 8193495 complement(3891800..3892453) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; hypothetical protein 3892453 8193495 METDI3965 Methylobacterium extorquens DM4 hypothetical protein YP_003069446.1 3891800 R 661410 CDS YP_003069447.1 254562352 8193496 complement(3892728..3893204) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3893204 8193496 METDI3966 Methylobacterium extorquens DM4 hypothetical protein YP_003069447.1 3892728 R 661410 CDS YP_003069448.1 254562353 8193497 3893374..3894588 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 14961129; Product type e : enzyme; A/G-specific adenine glycosylase 3894588 mutY 8193497 mutY Methylobacterium extorquens DM4 A/G-specific adenine glycosylase YP_003069448.1 3893374 D 661410 CDS YP_003069449.1 254562354 8195747 complement(3894652..3895848) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 11325934; Product type e : enzyme; site-specific DNA-methyltransferase (adenine-specific) 3895848 ccrfM 8195747 ccrfM Methylobacterium extorquens DM4 site-specific DNA-methyltransferase (adenine-specific) YP_003069449.1 3894652 R 661410 CDS YP_003069450.1 254562355 8195158 3896278..3896625 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; putative rare lipoprotein A precursor 3896625 8195158 METDI3969 Methylobacterium extorquens DM4 putative rare lipoprotein A precursor YP_003069450.1 3896278 D 661410 CDS YP_003069451.1 254562356 8193498 3896753..3897070 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3897070 8193498 METDI3970 Methylobacterium extorquens DM4 hypothetical protein YP_003069451.1 3896753 D 661410 CDS YP_003069452.1 254562357 8193500 3897573..3899396 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative ATP-binding protein with two ATPase domains, ABC transporter related 3899396 8193500 METDI3972 Methylobacterium extorquens DM4 putative ATP-binding protein with two ATPase domains, ABC transporter related YP_003069452.1 3897573 D 661410 CDS YP_003069453.1 254562358 8193501 3899723..3901384 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 1370281; Product type pt : putative transporter; putative porin precursor ; putative exported protein 3901384 8193501 METDI3973 Methylobacterium extorquens DM4 putative porin precursor ; putative exported protein YP_003069453.1 3899723 D 661410 CDS YP_003069454.1 254562359 8193502 3901599..3903605 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3903605 8193502 METDI3974 Methylobacterium extorquens DM4 hypothetical protein YP_003069454.1 3901599 D 661410 CDS YP_003069455.1 254562360 8193503 complement(3903589..3904845) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative adenylate cyclase protein 3904845 8193503 METDI3975 Methylobacterium extorquens DM4 putative adenylate cyclase protein YP_003069455.1 3903589 R 661410 CDS YP_003069456.1 254562361 8193504 3904986..3905591 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3905591 8193504 METDI3976 Methylobacterium extorquens DM4 hypothetical protein YP_003069456.1 3904986 D 661410 CDS YP_003069457.1 254562362 8193505 complement(3905615..3907939) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative soluble lytic murein transglycosylase precursor 3907939 8193505 METDI3977 Methylobacterium extorquens DM4 putative soluble lytic murein transglycosylase precursor YP_003069457.1 3905615 R 661410 CDS YP_003069458.1 254562363 8193506 3908139..3909029 1 NC_012988.1 catalyzes the formation of dihydrodipicolinate from L-aspartate 4-semialdehyde and pyruvate in lysine and diaminopimelate biosynthesis; dihydrodipicolinate synthase 3909029 dapA 8193506 dapA Methylobacterium extorquens DM4 dihydrodipicolinate synthase YP_003069458.1 3908139 D 661410 CDS YP_003069459.1 254562364 8195270 3909132..3909605 1 NC_012988.1 binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus; both the tmRNA and SmpB are regulated in cell cycle-dependent manner; functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation; SsrA-binding protein 3909605 smpB 8195270 smpB Methylobacterium extorquens DM4 SsrA-binding protein YP_003069459.1 3909132 D 661410 CDS YP_003069460.1 254562365 8196118 complement(3909827..3910483) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3910483 8196118 METDI3980 Methylobacterium extorquens DM4 hypothetical protein YP_003069460.1 3909827 R 661410 CDS YP_003069461.1 254562366 8193507 complement(3910521..3910748) 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 3910748 8193507 METDI3981 Methylobacterium extorquens DM4 hypothetical protein YP_003069461.1 3910521 R 661410 CDS YP_003069462.1 254562367 8193508 complement(3910984..3911574) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 8787418; Product type e : enzyme; orotate phosphoribosyltransferase (OPRT) (OPRTase) 3911574 pyrE 8193508 pyrE Methylobacterium extorquens DM4 orotate phosphoribosyltransferase (OPRT) (OPRTase) YP_003069462.1 3910984 R 661410 CDS YP_003069463.1 254562368 8195950 complement(3911790..3912137) 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 3912137 8195950 METDI3983 Methylobacterium extorquens DM4 hypothetical protein YP_003069463.1 3911790 R 661410 CDS YP_003069464.1 254562369 8193509 3911916..3912182 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 3912182 8193509 METDI3984 Methylobacterium extorquens DM4 hypothetical protein YP_003069464.1 3911916 D 661410 CDS YP_003069465.1 254562370 8193510 complement(3912252..3914483) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; GTP pyrophosphokinase 3914483 relA 8193510 relA Methylobacterium extorquens DM4 GTP pyrophosphokinase YP_003069465.1 3912252 R 661410 CDS YP_003069466.1 254562371 8195978 complement(3914855..3915265) 1 NC_012988.1 Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits; DNA-directed RNA polymerase subunit omega 3915265 rpoZ 8195978 rpoZ Methylobacterium extorquens DM4 DNA-directed RNA polymerase subunit omega YP_003069466.1 3914855 R 661410 CDS YP_003069467.1 254562372 8196051 3915469..3916035 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 12886008, 16926146; Product type cp : cell process; NifU-like 3916035 8196051 METDI3987 Methylobacterium extorquens DM4 NifU-like YP_003069467.1 3915469 D 661410 CDS YP_003069468.1 254562373 8193511 3916193..3916873 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; Peptidase M22, glycoprotease 3916873 8193511 METDI3988 Methylobacterium extorquens DM4 Peptidase M22, glycoprotease YP_003069468.1 3916193 D 661410 CDS YP_003069469.1 254562374 8193512 3916870..3917391 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 2828880; Product type e : enzyme; Ribosomal-protein-alanine N-acetyltransferase 3917391 rimI 8193512 rimI Methylobacterium extorquens DM4 Ribosomal-protein-alanine N-acetyltransferase YP_003069469.1 3916870 D 661410 CDS YP_003069470.1 254562375 8195997 3917417..3918295 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16151217; Product type pe : putative enzyme; putative 1-acylglycerol-3-phosphate O-acyltransferase (plsC) 3918295 8195997 METDI3990 Methylobacterium extorquens DM4 putative 1-acylglycerol-3-phosphate O-acyltransferase (plsC) YP_003069470.1 3917417 D 661410 CDS YP_003069471.1 254562376 8193513 complement(3918300..3918740) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3918740 8193513 METDI3991 Methylobacterium extorquens DM4 hypothetical protein YP_003069471.1 3918300 R 661410 CDS YP_003069472.1 254562377 8193514 3918873..3920213 1 NC_012988.1 catalyzes the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine from N6-(dimethylallyl)adenosine (i(6)A); (dimethylallyl)adenosine tRNA methylthiotransferase 3920213 miaB 8193514 miaB Methylobacterium extorquens DM4 (dimethylallyl)adenosine tRNA methylthiotransferase YP_003069472.1 3918873 D 661410 CDS YP_003069473.1 254562378 8195695 3920250..3921356 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative enzyme with nucleoside triphosphate hydrolase domain 3921356 ybeZ 8195695 ybeZ Methylobacterium extorquens DM4 putative enzyme with nucleoside triphosphate hydrolase domain YP_003069473.1 3920250 D 661410 CDS YP_003069474.1 254562379 8196349 3921427..3921912 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 9623911; Product type pe : putative enzyme; putative metalloprotease 3921912 8196349 METDI3994 Methylobacterium extorquens DM4 putative metalloprotease YP_003069474.1 3921427 D 661410 CDS YP_003069475.1 254562380 8193515 3921949..3923097 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative HlyC/CorC family of transporters with CBS domains 3923097 8193515 METDI3995 Methylobacterium extorquens DM4 putative HlyC/CorC family of transporters with CBS domains YP_003069475.1 3921949 D 661410 CDS YP_003069476.1 254562381 8193516 3923126..3924829 1 NC_012988.1 Transfers the fatty acyl group on membrane lipoproteins; apolipoprotein N-acyltransferase 3924829 lnt 8193516 lnt Methylobacterium extorquens DM4 apolipoprotein N-acyltransferase YP_003069476.1 3923126 D 661410 CDS YP_003069477.1 254562382 8195640 3925012..3925785 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3925785 8195640 METDI3997 Methylobacterium extorquens DM4 hypothetical protein YP_003069477.1 3925012 D 661410 CDS YP_003069478.1 254562383 8193517 complement(3925896..3927488) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 1860824; Product type e : enzyme; catalase (hydroperoxidase II) 3927488 katA 8193517 katA Methylobacterium extorquens DM4 catalase (hydroperoxidase II) YP_003069478.1 3925896 R 661410 CDS YP_003069479.1 254562384 8195613 3927636..3928607 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 9190810, 9809430; Product type r : regulator; oxidative stress transcriptional regulator, LysR family 3928607 oxyR 8195613 oxyR Methylobacterium extorquens DM4 oxidative stress transcriptional regulator, LysR family YP_003069479.1 3927636 D 661410 CDS YP_003069480.1 254562385 8195821 3928761..3929816 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative transport protein (abrB-like) 3929816 8195821 METDI4000 Methylobacterium extorquens DM4 putative transport protein (abrB-like) YP_003069480.1 3928761 D 661410 CDS YP_003069481.1 254562386 8193518 3929780..3930157 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative diacylglycerol kinase (dgkA-like) 3930157 8193518 METDI4001 Methylobacterium extorquens DM4 putative diacylglycerol kinase (dgkA-like) YP_003069481.1 3929780 D 661410 CDS YP_003069482.1 254562387 8193519 complement(3930180..3930377) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3930377 8193519 METDI4002 Methylobacterium extorquens DM4 hypothetical protein YP_003069482.1 3930180 R 661410 CDS YP_003069483.1 254562388 8193520 complement(3930374..3930574) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3930574 8193520 METDI4003 Methylobacterium extorquens DM4 hypothetical protein YP_003069483.1 3930374 R 661410 CDS YP_003069484.1 254562389 8193521 3930849..3931406 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3931406 8193521 METDI4004 Methylobacterium extorquens DM4 hypothetical protein YP_003069484.1 3930849 D 661410 CDS YP_003069485.1 254562390 8193522 complement(3931416..3932291) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 1355768, 8098327; Product type e : enzyme; glutamate racemase 3932291 murI 8193522 murI Methylobacterium extorquens DM4 glutamate racemase YP_003069485.1 3931416 R 661410 CDS YP_003069486.1 254562391 8195743 3932502..3933764 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3933764 8195743 METDI4006 Methylobacterium extorquens DM4 hypothetical protein YP_003069486.1 3932502 D 661410 CDS YP_003069487.1 254562392 8193523 3933822..3934799 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3934799 8193523 METDI4007 Methylobacterium extorquens DM4 hypothetical protein YP_003069487.1 3933822 D 661410 CDS YP_003069488.1 254562393 8193524 3935076..3937217 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 15033235; Product type pe : putative enzyme; hypothetical protein 3937217 8193524 METDI4008 Methylobacterium extorquens DM4 hypothetical protein YP_003069488.1 3935076 D 661410 CDS YP_003069489.1 254562394 8193525 complement(3937267..3937707) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3937707 8193525 METDI4009 Methylobacterium extorquens DM4 hypothetical protein YP_003069489.1 3937267 R 661410 CDS YP_003069490.1 254562395 8193526 3937930..3940617 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 8468296; Product type e : enzyme; nitrate reductase, large subunit 3940617 nasA 8193526 nasA Methylobacterium extorquens DM4 nitrate reductase, large subunit YP_003069490.1 3937930 D 661410 CDS YP_003069491.1 254562396 8195772 3940805..3942262 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; Siroheme synthase 3942262 cysG 8195772 cysG Methylobacterium extorquens DM4 Siroheme synthase YP_003069491.1 3940805 D 661410 CDS YP_003069492.1 254562397 8195253 3942548..3943150 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type c : carrier; Electron transport protein SenC-related 3943150 8195253 METDI4012 Methylobacterium extorquens DM4 Electron transport protein SenC-related YP_003069492.1 3942548 D 661410 CDS YP_003069493.1 254562398 8193527 complement(3943101..3944945) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative glycosyltransferase, putative membrane protein 3944945 8193527 METDI4013 Methylobacterium extorquens DM4 putative glycosyltransferase, putative membrane protein YP_003069493.1 3943101 R 661410 CDS YP_003069494.1 254562399 8193528 3945306..3945989 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative ABC transporter, periplasmic amino acid-binding protein 3945989 8193528 METDI4014 Methylobacterium extorquens DM4 putative ABC transporter, periplasmic amino acid-binding protein YP_003069494.1 3945306 D 661410 CDS YP_003069495.1 254562400 8193529 3946085..3946291 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 3946291 8193529 METDI4015 Methylobacterium extorquens DM4 hypothetical protein YP_003069495.1 3946085 D 661410 CDS YP_003069496.1 254562401 8193530 complement(3946315..3946725) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3946725 8193530 METDI4016 Methylobacterium extorquens DM4 hypothetical protein YP_003069496.1 3946315 R 661410 CDS YP_003069497.1 254562402 8193531 complement(3946819..3948726) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 1429466, 1917840; Product type e : enzyme; Cobaltochelatase (cobT protein) 3948726 cobT 8193531 cobT Methylobacterium extorquens DM4 Cobaltochelatase (cobT protein) YP_003069497.1 3946819 R 661410 CDS YP_003069498.1 254562403 8195199 complement(3948847..3949830) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 1429466, 1917840; Product type e : enzyme; Cobaltochelatase (cobS protein) 3949830 cobS 8195199 cobS Methylobacterium extorquens DM4 Cobaltochelatase (cobS protein) YP_003069498.1 3948847 R 661410 CDS YP_003069499.1 254562404 8195197 complement(3950006..3950176) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3950176 8195197 METDI4019 Methylobacterium extorquens DM4 hypothetical protein YP_003069499.1 3950006 R 661410 CDS YP_003069500.1 254562405 8193532 complement(3950170..3950877) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor; putative chaperone protein, DnaJ domain 3950877 8193532 METDI4020 Methylobacterium extorquens DM4 putative chaperone protein, DnaJ domain YP_003069500.1 3950170 R 661410 CDS YP_003069501.1 254562406 8193533 3951045..3951323 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor; BolA-like protein 3951323 8193533 METDI4021 Methylobacterium extorquens DM4 BolA-like protein YP_003069501.1 3951045 D 661410 CDS YP_003069502.1 254562407 8193534 3951355..3951777 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; Class I peptide chain release factor domain 3951777 8193534 METDI4022 Methylobacterium extorquens DM4 Class I peptide chain release factor domain YP_003069502.1 3951355 D 661410 CDS YP_003069503.1 254562408 8193535 complement(3951791..3952486) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3952486 8193535 METDI4023 Methylobacterium extorquens DM4 hypothetical protein YP_003069503.1 3951791 R 661410 CDS YP_003069504.1 254562409 8193536 complement(3952585..3953580) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3953580 8193536 METDI4024 Methylobacterium extorquens DM4 hypothetical protein YP_003069504.1 3952585 R 661410 CDS YP_003069505.1 254562410 8193537 3953626..3954684 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3954684 8193537 METDI4025 Methylobacterium extorquens DM4 hypothetical protein YP_003069505.1 3953626 D 661410 CDS YP_003069506.1 254562411 8193538 3954681..3956525 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative ATP-dependent DNA ligase 3956525 8193538 METDI4026 Methylobacterium extorquens DM4 putative ATP-dependent DNA ligase YP_003069506.1 3954681 D 661410 CDS YP_003069507.1 254562412 8193539 3956585..3957052 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3957052 8193539 METDI4027 Methylobacterium extorquens DM4 hypothetical protein YP_003069507.1 3956585 D 661410 CDS YP_003069508.1 254562413 8193540 3958002..3958160 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3958160 8193540 METDI4028 Methylobacterium extorquens DM4 hypothetical protein YP_003069508.1 3958002 D 661410 CDS YP_003069509.1 254562414 8193541 complement(3958169..3958615) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3958615 8193541 METDI4029 Methylobacterium extorquens DM4 hypothetical protein YP_003069509.1 3958169 R 661410 CDS YP_003069510.1 254562415 8193542 complement(3958738..3958902) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3958902 8193542 METDI4030 Methylobacterium extorquens DM4 hypothetical protein YP_003069510.1 3958738 R 661410 CDS YP_003069511.1 254562416 8193543 complement(3959005..3961206) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12535077; Product type pe : putative enzyme; putative fatty acid oxidation complex subunit alpha (enoyl-CoA hydratase and epimerase and isomerase ; 3-hydroxyacyl-CoA dehydrogenase) (fadJ-like; synonym yfcX) 3961206 8193543 METDI4031 Methylobacterium extorquens DM4 putative fatty acid oxidation complex subunit alpha (enoyl-CoA hydratase and epimerase and isomerase ; 3-hydroxyacyl-CoA dehydrogenase) (fadJ-like; synonym yfcX) YP_003069511.1 3959005 R 661410 CDS YP_003069512.1 254562417 8193544 3961328..3962125 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3962125 8193544 METDI4032 Methylobacterium extorquens DM4 hypothetical protein YP_003069512.1 3961328 D 661410 CDS YP_003069513.1 254562418 8193545 complement(3962201..3962698) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3962698 8193545 METDI4033 Methylobacterium extorquens DM4 hypothetical protein YP_003069513.1 3962201 R 661410 CDS YP_003069514.1 254562419 8193546 complement(3962826..3964034) 1 NC_012988.1 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; acetyl-CoA acetyltransferase 3964034 8193546 METDI4034 Methylobacterium extorquens DM4 acetyl-CoA acetyltransferase YP_003069514.1 3962826 R 661410 CDS YP_003069515.1 254562420 8193547 complement(3964221..3966011) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 12039753; Product type e : enzyme; acyl-CoA dehydrogenase 3966011 fadE 8193547 fadE Methylobacterium extorquens DM4 acyl-CoA dehydrogenase YP_003069515.1 3964221 R 661410 CDS YP_003069516.1 254562421 8195352 3966322..3969645 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3969645 8195352 METDI4036 Methylobacterium extorquens DM4 hypothetical protein YP_003069516.1 3966322 D 661410 CDS YP_003069517.1 254562422 8193548 3970096..3970422 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3970422 8193548 METDI4037 Methylobacterium extorquens DM4 hypothetical protein YP_003069517.1 3970096 D 661410 CDS YP_003069518.1 254562423 8193549 complement(3970480..3971424) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3971424 8193549 METDI4038 Methylobacterium extorquens DM4 hypothetical protein YP_003069518.1 3970480 R 661410 CDS YP_003069519.1 254562424 8193550 3971562..3972080 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3972080 8193550 METDI4039 Methylobacterium extorquens DM4 hypothetical protein YP_003069519.1 3971562 D 661410 CDS YP_003069520.1 254562425 8193551 3972077..3972880 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3972880 8193551 METDI4040 Methylobacterium extorquens DM4 hypothetical protein YP_003069520.1 3972077 D 661410 CDS YP_003069521.1 254562426 8193552 3972936..3974243 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8472911; Product type pe : putative enzyme; putative oxidoreductase precursor (tat pathway signal) 3974243 8193552 METDI4042 Methylobacterium extorquens DM4 putative oxidoreductase precursor (tat pathway signal) YP_003069521.1 3972936 D 661410 CDS YP_003069522.1 254562427 8193553 complement(3974355..3974501) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3974501 8193553 METDI4043 Methylobacterium extorquens DM4 hypothetical protein YP_003069522.1 3974355 R 661410 CDS YP_003069523.1 254562428 8193554 complement(3974582..3975877) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative protease 3975877 8193554 METDI4044 Methylobacterium extorquens DM4 putative protease YP_003069523.1 3974582 R 661410 CDS YP_003069524.1 254562429 8193555 complement(3976099..3977511) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 1333566; Product type e : enzyme; threonine synthase 3977511 thrC 8193555 thrC Methylobacterium extorquens DM4 threonine synthase YP_003069524.1 3976099 R 661410 CDS YP_003069525.1 254562430 8196194 complement(3977597..3978010) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3978010 8196194 METDI4046 Methylobacterium extorquens DM4 hypothetical protein YP_003069525.1 3977597 R 661410 CDS YP_003069526.1 254562431 8193556 complement(3978108..3978869) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10622737; Product type pm : putative membrane component; putative surfeit locus 1 family protein (surf1-like) 3978869 8193556 METDI4047 Methylobacterium extorquens DM4 putative surfeit locus 1 family protein (surf1-like) YP_003069526.1 3978108 R 661410 CDS YP_003069527.1 254562432 8193557 complement(3978878..3979252) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3979252 8193557 METDI4048 Methylobacterium extorquens DM4 hypothetical protein YP_003069527.1 3978878 R 661410 CDS YP_003069528.1 254562433 8193558 complement(3979379..3980236) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 7651515; Product type e : enzyme; cytochrome c oxidase subunit III 3980236 coxC 8193558 coxC Methylobacterium extorquens DM4 cytochrome c oxidase subunit III YP_003069528.1 3979379 R 661410 CDS YP_003069529.1 254562434 8195207 complement(3980383..3980991) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor; putative cytochrome-c oxidase assembly protein (coxG) 3980991 8195207 METDI4050 Methylobacterium extorquens DM4 putative cytochrome-c oxidase assembly protein (coxG) YP_003069529.1 3980383 R 661410 CDS YP_003069530.1 254562435 8193559 complement(3981004..3981180) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative CoxF 3981180 8193559 METDI4051 Methylobacterium extorquens DM4 putative CoxF YP_003069530.1 3981004 R 661410 CDS YP_003069531.1 254562436 8193560 complement(3981177..3982130) 1 NC_012988.1 converts protoheme IX and farnesyl diphosphate to heme O; protoheme IX farnesyltransferase 3982130 coxE 8193560 coxE Methylobacterium extorquens DM4 protoheme IX farnesyltransferase YP_003069531.1 3981177 R 661410 CDS YP_003069532.1 254562437 8195208 complement(3982296..3983924) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 9380672; Product type e : enzyme; cytochrome c oxidase subunit I 3983924 coxA 8195208 coxA Methylobacterium extorquens DM4 cytochrome c oxidase subunit I YP_003069532.1 3982296 R 661410 CDS YP_003069533.1 254562438 8195205 complement(3984002..3984841) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; cytochrome c oxidase subunit II 3984841 coxB 8195205 coxB Methylobacterium extorquens DM4 cytochrome c oxidase subunit II YP_003069533.1 3984002 R 661410 CDS YP_003069534.1 254562439 8195206 3985097..3985972 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor; putative formate dehydrogenase accesory protein 3985972 8195206 METDI4055 Methylobacterium extorquens DM4 putative formate dehydrogenase accesory protein YP_003069534.1 3985097 D 661410 CDS YP_003069535.1 254562440 8193561 complement(3986000..3987025) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3987025 8193561 METDI4056 Methylobacterium extorquens DM4 hypothetical protein YP_003069535.1 3986000 R 661410 CDS YP_003069536.1 254562441 8193562 3987662..3992380 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 7727752; Product type e : enzyme; glutamate synthase, large subunit 3992380 gltB 8193562 gltB Methylobacterium extorquens DM4 glutamate synthase, large subunit YP_003069536.1 3987662 D 661410 CDS YP_003069537.1 254562442 8195512 3992504..3993937 1 NC_012988.1 glutamate synthase is composed of subunits alpha and beta; beta subunit is a flavin adenine dinucleotide-NADPH dependent oxidoreductase; provides electrons to the alpha subunit, which binds L-glutamine and 2-oxoglutarate and forms L-glutamate; glutamate synthase subunit beta 3993937 gltD 8195512 gltD Methylobacterium extorquens DM4 glutamate synthase subunit beta YP_003069537.1 3992504 D 661410 CDS YP_003069538.1 254562443 8195513 3994211..3994801 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3994801 8195513 METDI4059 Methylobacterium extorquens DM4 hypothetical protein YP_003069538.1 3994211 D 661410 CDS YP_003069539.1 254562444 8193563 complement(3994774..3995697) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative hydrolase, beta-lactamase family protein 3995697 8193563 METDI4060 Methylobacterium extorquens DM4 putative hydrolase, beta-lactamase family protein YP_003069539.1 3994774 R 661410 CDS YP_003069540.1 254562445 8193564 3995876..3997216 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative transmembrane histidine kinase; putative domains: HK dimerisation, ATPase 3997216 8193564 METDI4061 Methylobacterium extorquens DM4 putative transmembrane histidine kinase; putative domains: HK dimerisation, ATPase YP_003069540.1 3995876 D 661410 CDS YP_003069541.1 254562446 8193565 3997222..3997884 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative response regulator; Input and output domains: CheY and HTH LuxR family 3997884 8193565 METDI4062 Methylobacterium extorquens DM4 putative response regulator; Input and output domains: CheY and HTH LuxR family YP_003069541.1 3997222 D 661410 CDS YP_003069542.1 254562447 8193566 complement(3997912..3999363) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3999363 8193566 METDI4063 Methylobacterium extorquens DM4 hypothetical protein YP_003069542.1 3997912 R 661410 CDS YP_003069543.1 254562448 8193567 complement(3999634..4000815) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative membrane bound lytic murein transglycosylase B, mltB 4000815 8193567 METDI4064 Methylobacterium extorquens DM4 putative membrane bound lytic murein transglycosylase B, mltB YP_003069543.1 3999634 R 661410 CDS YP_003069544.1 254562449 8193568 complement(4000812..4001804) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; UDP-galactose 4-epimerase 4001804 galE 8193568 galE Methylobacterium extorquens DM4 UDP-galactose 4-epimerase YP_003069544.1 4000812 R 661410 CDS YP_003069545.1 254562450 8195462 4001977..4002843 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; glucose-1-phosphate uridylyltransferase 4002843 galU 8195462 galU Methylobacterium extorquens DM4 glucose-1-phosphate uridylyltransferase YP_003069545.1 4001977 D 661410 CDS YP_003069546.1 254562451 8195464 complement(4003085..4003930) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; N-formylglutamate amidohydrolase (Beta-citryl-L-glutamate hydrolase) 4003930 8195464 METDI4067 Methylobacterium extorquens DM4 N-formylglutamate amidohydrolase (Beta-citryl-L-glutamate hydrolase) YP_003069546.1 4003085 R 661410 CDS YP_003069547.1 254562452 8193569 4004288..4004644 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative response regulator receiver; CheY-like protein 4004644 8193569 METDI4068 Methylobacterium extorquens DM4 putative response regulator receiver; CheY-like protein YP_003069547.1 4004288 D 661410 CDS YP_003069548.1 254562453 8193570 4004871..4005128 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 11031118, 7937896, 8636094, 94316500, 95024051, 99175138, 9973569; Product type c : carrier; glutaredoxin 3 4005128 grxC 8193570 grxC Methylobacterium extorquens DM4 glutaredoxin 3 YP_003069548.1 4004871 D 661410 CDS YP_003069549.1 254562454 8195536 4005125..4005970 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; Nitrilase/cyanide hydratase and apolipoprotein N-acyltransferase 4005970 8195536 METDI4070 Methylobacterium extorquens DM4 Nitrilase/cyanide hydratase and apolipoprotein N-acyltransferase YP_003069549.1 4005125 D 661410 CDS YP_003069550.1 254562455 8193571 4006091..4006567 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4006567 8193571 METDI4071 Methylobacterium extorquens DM4 hypothetical protein YP_003069550.1 4006091 D 661410 CDS YP_003069551.1 254562456 8193572 complement(4006587..4007651) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative histidine kinase; putative HK, ATPase and sensory PAS domain 4007651 8193572 METDI4072 Methylobacterium extorquens DM4 putative histidine kinase; putative HK, ATPase and sensory PAS domain YP_003069551.1 4006587 R 661410 CDS YP_003069552.1 254562457 8193573 4007827..4008486 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 10964927, 11080639, 11677230, 1386361, 94156870, 7836279; Product type e : enzyme; Peptide methionine sulfoxide reductase msrA (Protein-methionine-S-oxide reductase) (Peptide Met(O) reductase) 4008486 msrA 8193573 msrA Methylobacterium extorquens DM4 Peptide methionine sulfoxide reductase msrA (Protein-methionine-S-oxide reductase) (Peptide Met(O) reductase) YP_003069552.1 4007827 D 661410 CDS YP_003069553.1 254562458 8195728 4008591..4009094 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; hypothetical protein 4009094 yqhA 8195728 yqhA Methylobacterium extorquens DM4 hypothetical protein YP_003069553.1 4008591 D 661410 CDS YP_003069554.1 254562459 8196377 complement(4009102..4010031) 1 NC_012988.1 D-alanyl-D-alanine endopeptidase; functions in hydrolyzing cell wall peptidoglycan; similar to LAS metallopeptidases; forms a dimer in periplasm; penicillin-insensitive murein endopeptidase 4010031 mepA 8196377 mepA Methylobacterium extorquens DM4 penicillin-insensitive murein endopeptidase YP_003069554.1 4009102 R 661410 CDS YP_003069555.1 254562460 8195679 4010158..4010553 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4010553 8195679 METDI4076 Methylobacterium extorquens DM4 hypothetical protein YP_003069555.1 4010158 D 661410 CDS YP_003069556.1 254562461 8193574 complement(4010584..4010931) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4010931 8193574 METDI4077 Methylobacterium extorquens DM4 hypothetical protein YP_003069556.1 4010584 R 661410 CDS YP_003069557.1 254562462 8193575 complement(4011017..4012258) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 91250446, 92283803, 93131914; Product type t : transporter; sodium:proton antiporter (NhaA family) 4012258 nhaA 8193575 nhaA Methylobacterium extorquens DM4 sodium:proton antiporter (NhaA family) YP_003069557.1 4011017 R 661410 CDS YP_003069558.1 254562463 8195777 complement(4012330..4012971) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; Redoxin domain protein 4012971 8195777 METDI4079 Methylobacterium extorquens DM4 Redoxin domain protein YP_003069558.1 4012330 R 661410 CDS YP_003069559.1 254562464 8193576 4013011..4014402 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 16201833; Product type e : enzyme; argininosuccinate lyase 4014402 argH 8193576 argH Methylobacterium extorquens DM4 argininosuccinate lyase YP_003069559.1 4013011 D 661410 CDS YP_003069560.1 254562465 8195089 4014499..4014810 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4014810 8195089 METDI4081 Methylobacterium extorquens DM4 hypothetical protein YP_003069560.1 4014499 D 661410 CDS YP_003069561.1 254562466 8193577 4014966..4015649 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4015649 8193577 METDI4082 Methylobacterium extorquens DM4 hypothetical protein YP_003069561.1 4014966 D 661410 CDS YP_003069562.1 254562467 8193578 complement(4015828..4016082) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4016082 8193578 METDI4083 Methylobacterium extorquens DM4 hypothetical protein YP_003069562.1 4015828 R 661410 CDS YP_003069563.1 254562468 8193579 complement(4016524..4017210) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative haloacid dehalogenase family hydrolase 4017210 8193579 METDI4084 Methylobacterium extorquens DM4 putative haloacid dehalogenase family hydrolase YP_003069563.1 4016524 R 661410 CDS YP_003069564.1 254562469 8193580 4017483..4019252 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative carbamoyl transferase 4019252 8193580 METDI4085 Methylobacterium extorquens DM4 putative carbamoyl transferase YP_003069564.1 4017483 D 661410 CDS YP_003069565.1 254562470 8193581 complement(4019316..4019660) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4019660 8193581 METDI4086 Methylobacterium extorquens DM4 hypothetical protein YP_003069565.1 4019316 R 661410 CDS YP_003069566.1 254562471 8193582 complement(4019757..4020431) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 1376111; Product type e : enzyme; haloacid dehalogenase, type II 4020431 8193582 METDI4087 Methylobacterium extorquens DM4 haloacid dehalogenase, type II YP_003069566.1 4019757 R 661410 CDS YP_003069567.1 254562472 8193583 complement(4020469..4022052) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 18832143; Product type m : membrane component; putative peptidoglycan lipid II flippase protein, MurJ (MviN)-like protein 4022052 8193583 METDI4088 Methylobacterium extorquens DM4 putative peptidoglycan lipid II flippase protein, MurJ (MviN)-like protein YP_003069567.1 4020469 R 661410 CDS YP_003069568.1 254562473 8193584 complement(4022299..4022898) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 10419947, 16926146; Product type e : enzyme; superoxide dismutase 4022898 sodB 8193584 sodB Methylobacterium extorquens DM4 superoxide dismutase YP_003069568.1 4022299 R 661410 CDS YP_003069569.1 254562474 8196120 4023268..4024260 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4024260 8196120 METDI4091 Methylobacterium extorquens DM4 hypothetical protein YP_003069569.1 4023268 D 661410 CDS YP_003069570.1 254562475 8193585 complement(4024330..4026081) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative histidine kinase of the HWE family 4026081 8193585 METDI4092 Methylobacterium extorquens DM4 putative histidine kinase of the HWE family YP_003069570.1 4024330 R 661410 CDS YP_003069571.1 254562476 8193586 complement(4026189..4027148) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15297914, 7517390; Product type pe : putative enzyme; putative glycosyl transferase 4027148 8193586 METDI4093 Methylobacterium extorquens DM4 putative glycosyl transferase YP_003069571.1 4026189 R 661410 CDS YP_003069572.1 254562477 8193587 complement(4027145..4028050) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative Glycosyl transferase, family 2 4028050 8193587 METDI4094 Methylobacterium extorquens DM4 putative Glycosyl transferase, family 2 YP_003069572.1 4027145 R 661410 CDS YP_003069573.1 254562478 8193588 complement(4028123..4029625) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; Peptidase 4029625 8193588 METDI4095 Methylobacterium extorquens DM4 Peptidase YP_003069573.1 4028123 R 661410 CDS YP_003069574.1 254562479 8193589 complement(4029632..4030483) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4030483 8193589 METDI4096 Methylobacterium extorquens DM4 hypothetical protein YP_003069574.1 4029632 R 661410 CDS YP_003069575.1 254562480 8195035 4031202..4031624 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcriptional regulator 4031624 8195035 METDI4097 Methylobacterium extorquens DM4 putative transcriptional regulator YP_003069575.1 4031202 D 661410 CDS YP_003069576.1 254562481 8193591 4031832..4033007 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type e : enzyme; methionine adenosyltransferase 1 (AdoMet synthetase) 4033007 metK 8193591 metK Methylobacterium extorquens DM4 methionine adenosyltransferase 1 (AdoMet synthetase) YP_003069576.1 4031832 D 661410 CDS YP_003069577.1 254562482 8195685 4033017..4033754 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; tRNA (guanine-N(7)-)-methyltransferase (tRNA(m7G46)-methyltransferase) 4033754 trmB 8195685 trmB Methylobacterium extorquens DM4 tRNA (guanine-N(7)-)-methyltransferase (tRNA(m7G46)-methyltransferase) YP_003069577.1 4033017 D 661410 CDS YP_003069578.1 254562483 8196210 complement(4034008..4036740) 1 NC_012988.1 catalyzes the ATP-dependent breakage of single-stranded DNA followed by passage and rejoining, maintains net negative superhelicity; DNA topoisomerase I 4036740 TopA 8196210 TopA Methylobacterium extorquens DM4 DNA topoisomerase I YP_003069578.1 4034008 R 661410 CDS YP_003069579.1 254562484 8196206 complement(4036889..4037848) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; Sulfite oxidase, oxidoreductase molybdopterin binding 4037848 8196206 METDI4101 Methylobacterium extorquens DM4 Sulfite oxidase, oxidoreductase molybdopterin binding YP_003069579.1 4036889 R 661410 CDS YP_003069580.1 254562485 8193592 complement(4037845..4038717) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4038717 8193592 METDI4102 Methylobacterium extorquens DM4 hypothetical protein YP_003069580.1 4037845 R 661410 CDS YP_003069581.1 254562486 8193593 complement(4038882..4039193) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4039193 8193593 METDI4103 Methylobacterium extorquens DM4 hypothetical protein YP_003069581.1 4038882 R 661410 CDS YP_003069582.1 254562487 8193594 4039468..4040415 1 NC_012988.1 catalyzes the transfer of the carbamoyl moiety from carbamoyl phosphate to L- aspartate in pyrimidine biosynthesis; aspartate carbamoyltransferase catalytic subunit 4040415 pyrB 8193594 pyrB Methylobacterium extorquens DM4 aspartate carbamoyltransferase catalytic subunit YP_003069582.1 4039468 D 661410 CDS YP_003069583.1 254562488 8195946 4040421..4041725 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 7516791, 7896697; Product type pe : putative enzyme; putative dihydroorotase-like protein 4041725 pyrC 8195946 pyrC Methylobacterium extorquens DM4 putative dihydroorotase-like protein YP_003069583.1 4040421 D 661410 CDS YP_003069584.1 254562489 8195947 4041722..4042330 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16949372; Product type pe : putative enzyme; putative 1-acyl glycerol-3-phosphate synthetase (PlsY) 4042330 8195947 METDI4106 Methylobacterium extorquens DM4 putative 1-acyl glycerol-3-phosphate synthetase (PlsY) YP_003069584.1 4041722 D 661410 CDS YP_003069585.1 254562490 8193595 4042362..4043555 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type f : factor; DNA protecting protein DprA 4043555 DprA 8193595 DprA Methylobacterium extorquens DM4 DNA protecting protein DprA YP_003069585.1 4042362 D 661410 CDS YP_003069586.1 254562491 8195316 4043879..4044706 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4044706 8195316 METDI4108 Methylobacterium extorquens DM4 hypothetical protein YP_003069586.1 4043879 D 661410 CDS YP_003069587.1 254562492 8193596 4044703..4045854 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4045854 8193596 METDI4109 Methylobacterium extorquens DM4 hypothetical protein YP_003069587.1 4044703 D 661410 CDS YP_003069588.1 254562493 8193597 4045945..4046619 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 12244065, 8626329, 8885414; Product type e : enzyme; isonitrile hydratase, ThiJ/PfpI family protein 4046619 inh 8193597 inh Methylobacterium extorquens DM4 isonitrile hydratase, ThiJ/PfpI family protein YP_003069588.1 4045945 D 661410 CDS YP_003069589.1 254562494 8195601 complement(4046616..4047098) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10982859, 14512736; Product type pe : putative enzyme; putative Holliday junction resolvase 4047098 8195601 METDI4111 Methylobacterium extorquens DM4 putative Holliday junction resolvase YP_003069589.1 4046616 R 661410 CDS YP_003069590.1 254562495 8193598 complement(4047110..4047688) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4047688 8193598 METDI4112 Methylobacterium extorquens DM4 hypothetical protein YP_003069590.1 4047110 R 661410 CDS YP_003069591.1 254562496 8193599 4047849..4048034 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4048034 8193599 METDI4113 Methylobacterium extorquens DM4 hypothetical protein YP_003069591.1 4047849 D 661410 CDS YP_003069592.1 254562497 8193600 4048193..4048480 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit C (Asp/Glu-ADT subunit C) 4048480 gatC 8193600 gatC Methylobacterium extorquens DM4 Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit C (Asp/Glu-ADT subunit C) YP_003069592.1 4048193 D 661410 CDS YP_003069593.1 254562498 8195471 4048577..4050058 1 NC_012988.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; aspartyl/glutamyl-tRNA amidotransferase subunit A 4050058 gatA 8195471 gatA Methylobacterium extorquens DM4 aspartyl/glutamyl-tRNA amidotransferase subunit A YP_003069593.1 4048577 D 661410 CDS YP_003069594.1 254562499 8195468 4050055..4050360 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4050360 8195468 METDI4116 Methylobacterium extorquens DM4 hypothetical protein YP_003069594.1 4050055 D 661410 CDS YP_003069595.1 254562500 8193602 complement(4050881..4054045) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type t : transporter; multidrug efflux system protein (acrB ou acrF) 4054045 8193602 METDI4118 Methylobacterium extorquens DM4 multidrug efflux system protein (acrB ou acrF) YP_003069595.1 4050881 R 661410 CDS YP_003069596.1 254562501 8193603 complement(4054124..4055449) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type m : membrane component; putative RND efflux transporter, membrane fusion protein subunit 4055449 8193603 METDI4119 Methylobacterium extorquens DM4 putative RND efflux transporter, membrane fusion protein subunit YP_003069596.1 4054124 R 661410 CDS YP_003069597.1 254562502 8193604 complement(4055830..4056258) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4056258 8193604 METDI4120 Methylobacterium extorquens DM4 hypothetical protein YP_003069597.1 4055830 R 661410 CDS YP_003069598.1 254562503 8193605 4056492..4057091 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4057091 8193605 METDI4121 Methylobacterium extorquens DM4 hypothetical protein YP_003069598.1 4056492 D 661410 CDS YP_003069599.1 254562504 8193606 4057319..4057639 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4057639 8193606 METDI4122 Methylobacterium extorquens DM4 hypothetical protein YP_003069599.1 4057319 D 661410 CDS YP_003069600.1 254562505 8193607 4057671..4058993 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 11566369, 12951250; Product type e : enzyme; Trans-sulfuration enzyme (O-acetylhomoserine aminocarboxypropyltransferase) 4058993 metY-1 8193607 metY-1 Methylobacterium extorquens DM4 Trans-sulfuration enzyme (O-acetylhomoserine aminocarboxypropyltransferase) YP_003069600.1 4057671 D 661410 CDS YP_003069601.1 254562506 8195688 4058995..4060017 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; 2OG-Fe(II) oxygenase superfamily protein 4060017 8195688 METDI4124 Methylobacterium extorquens DM4 2OG-Fe(II) oxygenase superfamily protein YP_003069601.1 4058995 D 661410 CDS YP_003069602.1 254562507 8193608 4060014..4060199 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4060199 8193608 METDI4125 Methylobacterium extorquens DM4 hypothetical protein YP_003069602.1 4060014 D 661410 CDS YP_003069603.1 254562508 8193609 4060130..4060300 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4060300 8193609 METDI4126 Methylobacterium extorquens DM4 hypothetical protein YP_003069603.1 4060130 D 661410 CDS YP_003069604.1 254562509 8193610 4060431..4060667 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4060667 8193610 METDI4127 Methylobacterium extorquens DM4 hypothetical protein YP_003069604.1 4060431 D 661410 CDS YP_003069605.1 254562510 8193611 complement(4060759..4061031) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; Usg family protein 4061031 8193611 METDI4128 Methylobacterium extorquens DM4 Usg family protein YP_003069605.1 4060759 R 661410 CDS YP_003069606.1 254562511 8193612 complement(4061414..4063036) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 10619429, 12475168, 12653476, 1349729, 25784, 91129229, 91338746, 94171713; Product type f : factor; 60 kDa chaperonin (protein Cpn60, groEL protein) 4063036 groL 8193612 groL Methylobacterium extorquens DM4 60 kDa chaperonin (protein Cpn60, groEL protein) YP_003069606.1 4061414 R 661410 CDS YP_003069607.1 254562512 8195532 complement(4063072..4063362) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 11259647, 8821938; Product type f : factor; 10 kDa chaperonin (Protein Cpn10) (groES protein) 4063362 groS 8195532 groS Methylobacterium extorquens DM4 10 kDa chaperonin (Protein Cpn10) (groES protein) YP_003069607.1 4063072 R 661410 CDS YP_003069608.1 254562513 8195534 complement(4063626..4064849) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15661012; Product type pe : putative enzyme; putative acyl-CoA dehydrogenase 4064849 8195534 METDI4131 Methylobacterium extorquens DM4 putative acyl-CoA dehydrogenase YP_003069608.1 4063626 R 661410 CDS YP_003069609.1 254562514 8193613 complement(4065169..4067577) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4067577 8193613 METDI4132 Methylobacterium extorquens DM4 hypothetical protein YP_003069609.1 4065169 R 661410 CDS YP_003069610.1 254562515 8193614 4067723..4068763 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8011666, 9384377, 9782504; Product type pt : putative transporter; putative extracellular solute-binding protein precursor, putative sulfonate-binding protein precursor 4068763 8193614 METDI4133 Methylobacterium extorquens DM4 putative extracellular solute-binding protein precursor, putative sulfonate-binding protein precursor YP_003069610.1 4067723 D 661410 CDS YP_003069611.1 254562516 8193615 4068765..4069985 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative sulfite oxidase precursor (tat pathway signal) 4069985 8193615 METDI4134 Methylobacterium extorquens DM4 putative sulfite oxidase precursor (tat pathway signal) YP_003069611.1 4068765 D 661410 CDS YP_003069612.1 254562517 8193616 4069975..4070559 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type c : carrier; Cytochrome c, class I precursor 4070559 8193616 METDI4135 Methylobacterium extorquens DM4 Cytochrome c, class I precursor YP_003069612.1 4069975 D 661410 CDS YP_003069613.1 254562518 8193617 4070556..4071524 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 10361295, 10506196; Product type t : transporter; alkanesulfonate transport protein, periplasmic-binding subunit, ABC superfamily (tat pathway signal) 4071524 ssuA 8193617 ssuA Methylobacterium extorquens DM4 alkanesulfonate transport protein, periplasmic-binding subunit, ABC superfamily (tat pathway signal) YP_003069613.1 4070556 D 661410 CDS YP_003069614.1 254562519 8196150 4071521..4072576 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 9782504; Product type e : enzyme; Alkanesulfonate monooxygenase 4072576 ssuD 8196150 ssuD Methylobacterium extorquens DM4 Alkanesulfonate monooxygenase YP_003069614.1 4071521 D 661410 CDS YP_003069615.1 254562520 8196161 4072573..4073982 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type t : transporter; transporter 4073982 ygfU 8196161 ygfU Methylobacterium extorquens DM4 transporter YP_003069615.1 4072573 D 661410 CDS YP_003069616.1 254562521 8196365 complement(4073898..4074554) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; 2-hydroxychromene-2-carboxylate isomerase (HCCA isomerase) 4074554 nahD 8196365 nahD Methylobacterium extorquens DM4 2-hydroxychromene-2-carboxylate isomerase (HCCA isomerase) YP_003069616.1 4073898 R 661410 CDS YP_003069617.1 254562522 8195770 complement(4074551..4075432) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type t : transporter; ATP-binding component of ABC superfamily; putative alkanesulfonate transporter subunit 4075432 ssuB 8195770 ssuB Methylobacterium extorquens DM4 ATP-binding component of ABC superfamily; putative alkanesulfonate transporter subunit YP_003069617.1 4074551 R 661410 CDS YP_003069618.1 254562523 8196155 complement(4075429..4076304) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type t : transporter; ABC superfamily transporter membrane protein 4076304 8196155 METDI4141 Methylobacterium extorquens DM4 ABC superfamily transporter membrane protein YP_003069618.1 4075429 R 661410 CDS YP_003069619.1 254562524 8193618 complement(4076301..4077743) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type t : transporter; ABC family transporter, periplasmic protein 4077743 8193618 METDI4142 Methylobacterium extorquens DM4 ABC family transporter, periplasmic protein YP_003069619.1 4076301 R 661410 CDS YP_003069620.1 254562525 8193619 4078080..4078844 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcriptional regulator, Crp/Fnr family 4078844 8193619 METDI4143 Methylobacterium extorquens DM4 putative transcriptional regulator, Crp/Fnr family YP_003069620.1 4078080 D 661410 CDS YP_003069621.1 254562526 8193620 complement(4078882..4079862) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4079862 8193620 METDI4144 Methylobacterium extorquens DM4 hypothetical protein YP_003069621.1 4078882 R 661410 CDS YP_003069622.1 254562527 8193621 complement(4079859..4080092) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative ferredoxin 4080092 8193621 METDI4145 Methylobacterium extorquens DM4 putative ferredoxin YP_003069622.1 4079859 R 661410 CDS YP_003069623.1 254562528 8193622 complement(4080107..4081870) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative oxidoreductase 4081870 8193622 METDI4146 Methylobacterium extorquens DM4 putative oxidoreductase YP_003069623.1 4080107 R 661410 CDS YP_003069624.1 254562529 8193623 complement(4081867..4082190) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4082190 8193623 METDI4147 Methylobacterium extorquens DM4 hypothetical protein YP_003069624.1 4081867 R 661410 CDS YP_003069625.1 254562530 8193624 complement(4082727..4082906) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4082906 8193624 METDI4148 Methylobacterium extorquens DM4 hypothetical protein YP_003069625.1 4082727 R 661410 CDS YP_003069626.1 254562531 8193625 complement(4083312..4085339) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative membrane protein, diguanylate cyclase (GGDEF) domain 4085339 8193625 METDI4149 Methylobacterium extorquens DM4 putative membrane protein, diguanylate cyclase (GGDEF) domain YP_003069626.1 4083312 R 661410 CDS YP_003069627.1 254562532 8193626 complement(4085408..4085578) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4085578 8193626 METDI4150 Methylobacterium extorquens DM4 hypothetical protein YP_003069627.1 4085408 R 661410 CDS YP_003069628.1 254562533 8193627 4085750..4086775 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4086775 8193627 METDI4151 Methylobacterium extorquens DM4 hypothetical protein YP_003069628.1 4085750 D 661410 CDS YP_003069629.1 254562534 8193630 complement(4087416..4087739) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor; putative elongation factor, GreA/GreB family 4087739 8193630 METDI4154 Methylobacterium extorquens DM4 putative elongation factor, GreA/GreB family YP_003069629.1 4087416 R 661410 CDS YP_003069630.1 254562535 8193631 4088724..4089209 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4089209 8193631 METDI4156 Methylobacterium extorquens DM4 hypothetical protein YP_003069630.1 4088724 D 661410 CDS YP_003069631.1 254562536 8193632 complement(4089504..4089734) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4089734 8193632 METDI4157 Methylobacterium extorquens DM4 hypothetical protein YP_003069631.1 4089504 R 661410 CDS YP_003069632.1 254562537 8193633 complement(4090035..4090238) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4090238 8193633 METDI4158 Methylobacterium extorquens DM4 hypothetical protein YP_003069632.1 4090035 R 661410 CDS YP_003069633.1 254562538 8193634 complement(4090277..4090621) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4090621 8193634 METDI4159 Methylobacterium extorquens DM4 hypothetical protein YP_003069633.1 4090277 R 661410 CDS YP_003069634.1 254562539 8193635 complement(4090667..4090969) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4090969 8193635 METDI4160 Methylobacterium extorquens DM4 hypothetical protein YP_003069634.1 4090667 R 661410 CDS YP_003069635.1 254562540 8193636 4091085..4091312 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4091312 8193636 METDI4161 Methylobacterium extorquens DM4 hypothetical protein YP_003069635.1 4091085 D 661410 CDS YP_003069636.1 254562541 8193637 4091338..4093335 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative sensor hybrid histidine kinase with multiple PAS and response regulator receiver domains 4093335 8193637 METDI4162 Methylobacterium extorquens DM4 putative sensor hybrid histidine kinase with multiple PAS and response regulator receiver domains YP_003069636.1 4091338 D 661410 CDS YP_003069637.1 254562542 8193639 complement(4093878..4094081) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4094081 8193639 METDI4164 Methylobacterium extorquens DM4 hypothetical protein YP_003069637.1 4093878 R 661410 CDS YP_003069638.1 254562543 8193640 complement(4094417..4095379) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcriptional regulator, LysR family 4095379 8193640 METDI4165 Methylobacterium extorquens DM4 putative transcriptional regulator, LysR family YP_003069638.1 4094417 R 661410 CDS YP_003069639.1 254562544 8193643 4097001..4097876 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative ABC transporter, permease precursor; putative branched-chain amino acid transporter 4097876 8193643 METDI4168 Methylobacterium extorquens DM4 putative ABC transporter, permease precursor; putative branched-chain amino acid transporter YP_003069639.1 4097001 D 661410 CDS YP_003069640.1 254562545 8193644 4097873..4099654 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative ABC transporter, ATPase and permease; putative branched-chain amino acid transporter 4099654 8193644 METDI4169 Methylobacterium extorquens DM4 putative ABC transporter, ATPase and permease; putative branched-chain amino acid transporter YP_003069640.1 4097873 D 661410 CDS YP_003069641.1 254562546 8193645 4099654..4100391 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative ABC transporter, ATPase; putative branched-chain amino acid transporter 4100391 8193645 METDI4170 Methylobacterium extorquens DM4 putative ABC transporter, ATPase; putative branched-chain amino acid transporter YP_003069641.1 4099654 D 661410 CDS YP_003069642.1 254562547 8193646 4100473..4101174 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative cyclase 4101174 8193646 METDI4171 Methylobacterium extorquens DM4 putative cyclase YP_003069642.1 4100473 D 661410 CDS YP_003069643.1 254562548 8193647 4101180..4102637 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; amidase-related enzyme 4102637 8193647 METDI4172 Methylobacterium extorquens DM4 amidase-related enzyme YP_003069643.1 4101180 D 661410 CDS YP_003069644.1 254562549 8193648 complement(4102691..4102903) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4102903 8193648 METDI4173 Methylobacterium extorquens DM4 hypothetical protein YP_003069644.1 4102691 R 661410 CDS YP_003069645.1 254562550 8193649 complement(4103175..4104227) 1 NC_012988.1 aliphatic amidase; catalyzes the hydrolysis of short-chain aliphatic amides to their organic acids and can also transfer the acyl moiety of short-chain amides to hydroxylamine to form hydroxamates; acylamide amidohydrolase 4104227 amiE 8193649 amiE Methylobacterium extorquens DM4 acylamide amidohydrolase YP_003069645.1 4103175 R 661410 CDS YP_003069646.1 254562551 8195071 complement(4104303..4105718) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative carbohydrate-selective porin 4105718 8195071 METDI4175 Methylobacterium extorquens DM4 putative carbohydrate-selective porin YP_003069646.1 4104303 R 661410 CDS YP_003069647.1 254562552 8193650 complement(4105930..4106247) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative formamidase regulatory protein, FmdB family 4106247 8193650 METDI4176 Methylobacterium extorquens DM4 putative formamidase regulatory protein, FmdB family YP_003069647.1 4105930 R 661410 CDS YP_003069648.1 254562553 8193651 complement(4106312..4107541) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 8841393; Product type e : enzyme; formamidase 4107541 fmdA 8193651 fmdA Methylobacterium extorquens DM4 formamidase YP_003069648.1 4106312 R 661410 CDS YP_003069649.1 254562554 8195432 complement(4107705..4108721) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; hypothetical protein 4108721 8195432 METDI4178 Methylobacterium extorquens DM4 hypothetical protein YP_003069649.1 4107705 R 661410 CDS YP_003069650.1 254562555 8193652 complement(4108733..4109479) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative ABC transporter, ATP-binding component 4109479 8193652 METDI4179 Methylobacterium extorquens DM4 putative ABC transporter, ATP-binding component YP_003069650.1 4108733 R 661410 CDS YP_003069651.1 254562556 8193653 complement(4109493..4110281) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative leucine/isoleucine/valine transporter subunit (ATP-binding component of ABC superfamily) (livG) 4110281 8193653 METDI4180 Methylobacterium extorquens DM4 putative leucine/isoleucine/valine transporter subunit (ATP-binding component of ABC superfamily) (livG) YP_003069651.1 4109493 R 661410 CDS YP_003069652.1 254562557 8193654 complement(4110293..4111450) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type pt : putative transporter; putative branched-chain amino acid ABC transporter, permease protein 4111450 8193654 METDI4181 Methylobacterium extorquens DM4 putative branched-chain amino acid ABC transporter, permease protein YP_003069652.1 4110293 R 661410 CDS YP_003069653.1 254562558 8193655 complement(4111488..4112414) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative branched-chain amino acid ABC transporter, permease protein 4112414 8193655 METDI4182 Methylobacterium extorquens DM4 putative branched-chain amino acid ABC transporter, permease protein YP_003069653.1 4111488 R 661410 CDS YP_003069654.1 254562559 8193656 complement(4112524..4113777) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type t : transporter; putative branched-chain amino acid ABC transporter, substrate-binding protein 4113777 8193656 METDI4183 Methylobacterium extorquens DM4 putative branched-chain amino acid ABC transporter, substrate-binding protein YP_003069654.1 4112524 R 661410 CDS YP_003069655.1 254562560 8193657 4114271..4117450 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type prc : putative receptor; putative integral membrane sensor hybrid histidine kinase 4117450 8193657 METDI4184 Methylobacterium extorquens DM4 putative integral membrane sensor hybrid histidine kinase YP_003069655.1 4114271 D 661410 CDS YP_003069656.1 254562561 8193658 4117443..4118351 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative response regulator; input and output domains: CheY and LuxR family 4118351 8193658 METDI4185 Methylobacterium extorquens DM4 putative response regulator; input and output domains: CheY and LuxR family YP_003069656.1 4117443 D 661410 CDS YP_003069657.1 254562562 8193659 4118870..4119673 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4119673 8193659 METDI4186 Methylobacterium extorquens DM4 hypothetical protein YP_003069657.1 4118870 D 661410 CDS YP_003069659.1 254562564 8193661 4120224..4120982 1 NC_012988.1 [deacetylating]; catalyzes the formation of precorrin 6x from precorrin 5; precorrin 6A synthase 4120982 cobF 8193661 cobF Methylobacterium extorquens DM4 precorrin 6A synthase YP_003069659.1 4120224 D 661410 CDS YP_003069660.1 254562565 8195186 4121204..4122544 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4122544 8195186 METDI4189 Methylobacterium extorquens DM4 hypothetical protein YP_003069660.1 4121204 D 661410 CDS YP_003069661.1 254562566 8193662 complement(4122564..4123130) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4123130 8193662 METDI4190 Methylobacterium extorquens DM4 hypothetical protein YP_003069661.1 4122564 R 661410 CDS YP_003069662.1 254562567 8193663 4123491..4124180 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative ATPase, putative partition protein (ParA) 4124180 8193663 METDI4191 Methylobacterium extorquens DM4 putative ATPase, putative partition protein (ParA) YP_003069662.1 4123491 D 661410 CDS YP_003069663.1 254562568 8193664 4124164..4124517 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4124517 8193664 METDI4192 Methylobacterium extorquens DM4 hypothetical protein YP_003069663.1 4124164 D 661410 CDS YP_003069664.1 254562569 8193665 4124785..4126209 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type lp : lipoprotein; rare lipoprotein A family protein 4126209 8193665 METDI4193 Methylobacterium extorquens DM4 rare lipoprotein A family protein YP_003069664.1 4124785 D 661410 CDS YP_003069665.1 254562570 8193666 complement(4126388..4128286) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; PubMedId : 15188393, 16926146; hypothetical protein 4128286 8193666 METDI4194 Methylobacterium extorquens DM4 hypothetical protein YP_003069665.1 4126388 R 661410 CDS YP_003069666.1 254562571 8193667 complement(4128494..4128820) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 17698959; Product type f : factor; iron-sulfur cluster assembly accessory protein 4128820 8193667 METDI4195 Methylobacterium extorquens DM4 iron-sulfur cluster assembly accessory protein YP_003069666.1 4128494 R 661410 CDS YP_003069667.1 254562572 8193668 4128947..4130200 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 11756688; Product type e : enzyme; Deoxyguanosinetriphosphate triphosphohydrolase-like protein 4130200 dgt 8193668 dgt Methylobacterium extorquens DM4 Deoxyguanosinetriphosphate triphosphohydrolase-like protein YP_003069667.1 4128947 D 661410 CDS YP_003069668.1 254562573 8195293 complement(4130228..4130761) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4130761 8195293 METDI4197 Methylobacterium extorquens DM4 hypothetical protein YP_003069668.1 4130228 R 661410 CDS YP_003069669.1 254562574 8193669 4130891..4131352 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; thioesterase superfamily protein 4131352 8193669 METDI4198 Methylobacterium extorquens DM4 thioesterase superfamily protein YP_003069669.1 4130891 D 661410 CDS YP_003069670.1 254562575 8193670 4131447..4133204 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; arginyl-tRNA synthetase 4133204 argS 8193670 argS Methylobacterium extorquens DM4 arginyl-tRNA synthetase YP_003069670.1 4131447 D 661410 CDS YP_003069671.1 254562576 8195091 4133234..4134640 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4134640 8195091 METDI4200 Methylobacterium extorquens DM4 hypothetical protein YP_003069671.1 4133234 D 661410 CDS YP_003069672.1 254562577 8193671 4134850..4135881 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative beta N-acetyl-glucosaminidase (nagZ-like) 4135881 8193671 METDI4201 Methylobacterium extorquens DM4 putative beta N-acetyl-glucosaminidase (nagZ-like) YP_003069672.1 4134850 D 661410 CDS YP_003069673.1 254562578 8193672 4136147..4136434 1 NC_012988.1 TatA; similar to TatE that is found in some proteobacteria; part of system that translocates proteins with a conserved twin arginine motif across the inner membrane; capable of translocating folded substrates typically those with bound cofactors; similar to a protein import system in thylakoid membranes; twin arginine translocase protein A 4136434 tatA 8193672 tatA Methylobacterium extorquens DM4 twin arginine translocase protein A YP_003069673.1 4136147 D 661410 CDS YP_003069674.1 254562579 8196179 4136578..4137039 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type pt : putative transporter; Sec-independent protein translocase protein 4137039 tatB 8196179 tatB Methylobacterium extorquens DM4 Sec-independent protein translocase protein YP_003069674.1 4136578 D 661410 CDS YP_003069675.1 254562580 8196180 4137036..4137836 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type t : transporter; Sec-independent protein translocase protein 4137836 tatC 8196180 tatC Methylobacterium extorquens DM4 Sec-independent protein translocase protein YP_003069675.1 4137036 D 661410 CDS YP_003069676.1 254562581 8196181 4137997..4138695 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4138695 8196181 METDI4206 Methylobacterium extorquens DM4 hypothetical protein YP_003069676.1 4137997 D 661410 CDS YP_003069677.1 254562582 8193673 complement(4138702..4139877) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative transmembrane efflux protein; MFS family (ydhP-like) 4139877 8193673 METDI4207 Methylobacterium extorquens DM4 putative transmembrane efflux protein; MFS family (ydhP-like) YP_003069677.1 4138702 R 661410 CDS YP_003069678.1 254562583 8193674 4140287..4140856 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 10049377, 10506196; Product type e : enzyme; NAD(P)H-dependent FMN reductase 4140856 ssuE 8193674 ssuE Methylobacterium extorquens DM4 NAD(P)H-dependent FMN reductase YP_003069678.1 4140287 D 661410 CDS YP_003069679.1 254562584 8196163 4140858..4141841 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 10361295, 10506196; Product type t : transporter; alkanesulfonate transport protein, periplasmic-binding subunit, ABC superfamily 4141841 ssuA 8196163 ssuA Methylobacterium extorquens DM4 alkanesulfonate transport protein, periplasmic-binding subunit, ABC superfamily YP_003069679.1 4140858 D 661410 CDS YP_003069680.1 254562585 8196151 4141838..4142698 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 10361295, 10506196; Product type t : transporter; alkanesulfonate transport protein, membrane component of ABC superfamily 4142698 ssuC 8196151 ssuC Methylobacterium extorquens DM4 alkanesulfonate transport protein, membrane component of ABC superfamily YP_003069680.1 4141838 D 661410 CDS YP_003069681.1 254562586 8196160 4142738..4143529 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 10361295, 10506196; Product type t : transporter; alkanesulfonate transport protein, ATP-binding protein 4143529 ssuB 8196160 ssuB Methylobacterium extorquens DM4 alkanesulfonate transport protein, ATP-binding protein YP_003069681.1 4142738 D 661410 CDS YP_003069682.1 254562587 8196156 4143558..4144733 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 10506196; Product type e : enzyme; alkanesulfonate monooxygenase 4144733 ssuD 8196156 ssuD Methylobacterium extorquens DM4 alkanesulfonate monooxygenase YP_003069682.1 4143558 D 661410 CDS YP_003069683.1 254562588 8196162 4144752..4145726 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 10361295, 10506196; Product type t : transporter; alkanesulfonate transport protein, periplasmic-binding subunit, ABC superfamily 4145726 ssuA 8196162 ssuA Methylobacterium extorquens DM4 alkanesulfonate transport protein, periplasmic-binding subunit, ABC superfamily YP_003069683.1 4144752 D 661410 CDS YP_003069684.1 254562589 8196152 4145829..4146791 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 10361295, 10506196; Product type t : transporter; alkanesulfonate transport protein, periplasmic-binding subunit, ABC superfamily 4146791 ssuA 8196152 ssuA Methylobacterium extorquens DM4 alkanesulfonate transport protein, periplasmic-binding subunit, ABC superfamily YP_003069684.1 4145829 D 661410 CDS YP_003069685.1 254562590 8196153 4146826..4148208 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative hydroxyacylglutathion hydrolase 4148208 8196153 METDI4215 Methylobacterium extorquens DM4 putative hydroxyacylglutathion hydrolase YP_003069685.1 4146826 D 661410 CDS YP_003069686.1 254562591 8193675 4148543..4148752 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4148752 8193675 METDI4216 Methylobacterium extorquens DM4 hypothetical protein YP_003069686.1 4148543 D 661410 CDS YP_003069687.1 254562592 8193676 4148992..4149669 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4149669 8193676 METDI4217 Methylobacterium extorquens DM4 hypothetical protein YP_003069687.1 4148992 D 661410 CDS YP_003069688.1 254562593 8193677 complement(4149785..4150945) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4150945 8193677 METDI4218 Methylobacterium extorquens DM4 hypothetical protein YP_003069688.1 4149785 R 661410 CDS YP_003069689.1 254562594 8193678 4151126..4154476 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4154476 8193678 METDI4219 Methylobacterium extorquens DM4 hypothetical protein YP_003069689.1 4151126 D 661410 CDS YP_003069690.1 254562595 8193679 4154473..4157013 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4157013 8193679 METDI4220 Methylobacterium extorquens DM4 hypothetical protein YP_003069690.1 4154473 D 661410 CDS YP_003069691.1 254562596 8193680 4157010..4157912 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; Transglutaminase-like domain 4157912 8193680 METDI4221 Methylobacterium extorquens DM4 Transglutaminase-like domain YP_003069691.1 4157010 D 661410 CDS YP_003069692.1 254562597 8193681 complement(4157926..4158582) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcriptional regulator, TetR family 4158582 8193681 METDI4222 Methylobacterium extorquens DM4 putative transcriptional regulator, TetR family YP_003069692.1 4157926 R 661410 CDS YP_003069693.1 254562598 8193682 4158664..4159404 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative short-chain dehydrogenase/reductase SDR 4159404 8193682 METDI4223 Methylobacterium extorquens DM4 putative short-chain dehydrogenase/reductase SDR YP_003069693.1 4158664 D 661410 CDS YP_003069694.1 254562599 8193683 complement(4159444..4160610) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type t : transporter; Drug resistance transporter, Bcr/CflA family 4160610 8193683 METDI4224 Methylobacterium extorquens DM4 Drug resistance transporter, Bcr/CflA family YP_003069694.1 4159444 R 661410 CDS YP_003069695.1 254562600 8193684 complement(4160942..4161517) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4161517 8193684 METDI4225 Methylobacterium extorquens DM4 hypothetical protein YP_003069695.1 4160942 R 661410 CDS YP_003069696.1 254562601 8193685 4161762..4163588 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative serine-type D-Ala-D-Ala carboxypeptidase 4163588 8193685 METDI4226 Methylobacterium extorquens DM4 putative serine-type D-Ala-D-Ala carboxypeptidase YP_003069696.1 4161762 D 661410 CDS YP_003069697.1 254562602 8193686 4163777..4165300 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 15188393, 16926146, 9511738; Product type e : enzyme; aldehyde dehydrogenase, chloroacetaldehyde dehydrogenase 4165300 aldA 8193686 aldA Methylobacterium extorquens DM4 aldehyde dehydrogenase, chloroacetaldehyde dehydrogenase YP_003069697.1 4163777 D 661410 CDS YP_003069698.1 254562603 8195068 4165823..4167466 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type prc : putative receptor; putative methyl-accepting chemotaxis sensory transducer precursor 4167466 8195068 METDI4228 Methylobacterium extorquens DM4 putative methyl-accepting chemotaxis sensory transducer precursor YP_003069698.1 4165823 D 661410 CDS YP_003069699.1 254562604 8193687 complement(4167577..4168866) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 6350601; Product type pe : putative enzyme; putative ornithine/diaminopimelate PLP-dependent decarboxylase 4168866 8193687 METDI4229 Methylobacterium extorquens DM4 putative ornithine/diaminopimelate PLP-dependent decarboxylase YP_003069699.1 4167577 R 661410 CDS YP_003069700.1 254562605 8193688 complement(4168872..4170389) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative AMP-dependent synthetase and ligase 4170389 8193688 METDI4230 Methylobacterium extorquens DM4 putative AMP-dependent synthetase and ligase YP_003069700.1 4168872 R 661410 CDS YP_003069701.1 254562606 8193689 complement(4170409..4170660) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor; putative Acyl carrier protein (ACP) 4170660 8193689 METDI4231 Methylobacterium extorquens DM4 putative Acyl carrier protein (ACP) YP_003069701.1 4170409 R 661410 CDS YP_003069702.1 254562607 8193690 4170882..4171409 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4171409 8193690 METDI4232 Methylobacterium extorquens DM4 hypothetical protein YP_003069702.1 4170882 D 661410 CDS YP_003069703.1 254562608 8193691 complement(4171366..4172886) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative multidrug efflux protein 4172886 8193691 METDI4233 Methylobacterium extorquens DM4 putative multidrug efflux protein YP_003069703.1 4171366 R 661410 CDS YP_003069704.1 254562609 8193692 4173144..4174031 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4174031 8193692 METDI4234 Methylobacterium extorquens DM4 hypothetical protein YP_003069704.1 4173144 D 661410 CDS YP_003069705.1 254562610 8193693 complement(4174115..4175920) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 12597275; Product type e : enzyme; Adenine deaminase (Adenase) (Adenine aminase) 4175920 ade 8193693 ade Methylobacterium extorquens DM4 Adenine deaminase (Adenase) (Adenine aminase) YP_003069705.1 4174115 R 661410 CDS YP_003069706.1 254562611 8195063 complement(4176005..4176724) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 10748051, 10814528, 10983982, 20287497, 8444796, 92021790, 93186701; Product type e : enzyme; Ribosomal RNA large subunit methyltransferase J (rRNA (uridine-2'-O-)-methyltransferase) (23S rRNA m2U2552 methyltransferase) 4176724 rrmJ 8195063 rrmJ Methylobacterium extorquens DM4 Ribosomal RNA large subunit methyltransferase J (rRNA (uridine-2'-O-)-methyltransferase) (23S rRNA m2U2552 methyltransferase) YP_003069706.1 4176005 R 661410 CDS YP_003069707.1 254562612 8196083 complement(4176908..4178035) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; exopolyphosphatase 4178035 8196083 METDI4237 Methylobacterium extorquens DM4 exopolyphosphatase YP_003069707.1 4176908 R 661410 CDS YP_003069708.1 254562613 8193694 complement(4178182..4179336) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16020541; Product type pe : putative enzyme; putative glycosyl transferase precursor, putative membrane protein 4179336 8193694 METDI4238 Methylobacterium extorquens DM4 putative glycosyl transferase precursor, putative membrane protein YP_003069708.1 4178182 R 661410 CDS YP_003069709.1 254562614 8193695 complement(4179333..4180148) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4180148 8193695 METDI4239 Methylobacterium extorquens DM4 hypothetical protein YP_003069709.1 4179333 R 661410 CDS YP_003069710.1 254562615 8193696 complement(4180160..4181698) 1 NC_012988.1 Evidence 1c : Function experimentally demonstrated in the studied genus; PubMedId : 14660416; Product type e : enzyme; phytoene desaturase (phytoene dehydrogenase) 4181698 ctrI 8193696 ctrI Methylobacterium extorquens DM4 phytoene desaturase (phytoene dehydrogenase) YP_003069710.1 4180160 R 661410 CDS YP_003069711.1 254562616 8195228 complement(4181797..4182657) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative Glutamine amidotransferase-like 4182657 8195228 METDI4241 Methylobacterium extorquens DM4 putative Glutamine amidotransferase-like YP_003069711.1 4181797 R 661410 CDS YP_003069712.1 254562617 8193697 complement(4182805..4184031) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative membrane component of an ABC transporter 4184031 8193697 METDI4242 Methylobacterium extorquens DM4 putative membrane component of an ABC transporter YP_003069712.1 4182805 R 661410 CDS YP_003069713.1 254562618 8193698 complement(4184028..4184996) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative Copper ABC transporter (nosF-like) 4184996 8193698 METDI4243 Methylobacterium extorquens DM4 putative Copper ABC transporter (nosF-like) YP_003069713.1 4184028 R 661410 CDS YP_003069714.1 254562619 8193699 complement(4185004..4185432) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4185432 8193699 METDI4244 Methylobacterium extorquens DM4 hypothetical protein YP_003069714.1 4185004 R 661410 CDS YP_003069715.1 254562620 8193700 complement(4185432..4187003) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative phytoene dehydrogenase 4187003 8193700 METDI4245 Methylobacterium extorquens DM4 putative phytoene dehydrogenase YP_003069715.1 4185432 R 661410 CDS YP_003069716.1 254562621 8193701 complement(4187137..4188636) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4188636 8193701 METDI4246 Methylobacterium extorquens DM4 hypothetical protein YP_003069716.1 4187137 R 661410 CDS YP_003069717.1 254562622 8193702 complement(4188751..4189560) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; TRNA/rRNA methyltransferase (SpoU) 4189560 spoU 8193702 spoU Methylobacterium extorquens DM4 TRNA/rRNA methyltransferase (SpoU) YP_003069717.1 4188751 R 661410 CDS YP_003069718.1 254562623 8196143 complement(4189630..4190103) 1 NC_012988.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11872727; Product type e : enzyme; crotonase 4190103 croR 8196143 croR Methylobacterium extorquens DM4 crotonase YP_003069718.1 4189630 R 661410 CDS YP_003069719.1 254562624 8195215 4190303..4190920 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4190920 8195215 METDI4249 Methylobacterium extorquens DM4 hypothetical protein YP_003069719.1 4190303 D 661410 CDS YP_003069720.1 254562625 8193703 4190957..4191805 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative metallophosphoesterase 4191805 8193703 METDI4250 Methylobacterium extorquens DM4 putative metallophosphoesterase YP_003069720.1 4190957 D 661410 CDS YP_003069721.1 254562626 8193704 4191898..4192119 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4192119 8193704 METDI4251 Methylobacterium extorquens DM4 hypothetical protein YP_003069721.1 4191898 D 661410 CDS YP_003069722.1 254562627 8193705 4192244..4193386 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4193386 8193705 METDI4252 Methylobacterium extorquens DM4 hypothetical protein YP_003069722.1 4192244 D 661410 CDS YP_003069723.1 254562628 8193706 4193437..4194048 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative glutathione S-transferase 4194048 8193706 METDI4253 Methylobacterium extorquens DM4 putative glutathione S-transferase YP_003069723.1 4193437 D 661410 CDS YP_003069724.1 254562629 8193707 4194219..4194431 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4194431 8193707 METDI4254 Methylobacterium extorquens DM4 hypothetical protein YP_003069724.1 4194219 D 661410 CDS YP_003069725.1 254562630 8193708 complement(4194623..4195816) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 9148748, 9165070, 9218780, 9915841; Product type e : enzyme; Glycine amidinotransferase (L-arginine:glycine amidinotransferase) 4195816 gatm 8193708 gatm Methylobacterium extorquens DM4 Glycine amidinotransferase (L-arginine:glycine amidinotransferase) YP_003069725.1 4194623 R 661410 CDS YP_003069726.1 254562631 8195472 4196064..4197161 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4197161 8195472 METDI4256 Methylobacterium extorquens DM4 hypothetical protein YP_003069726.1 4196064 D 661410 CDS YP_003069727.1 254562632 8193709 4197152..4197775 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4197775 8193709 METDI4257 Methylobacterium extorquens DM4 hypothetical protein YP_003069727.1 4197152 D 661410 CDS YP_003069728.1 254562633 8193710 4197959..4199155 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative glycosyl transferase, putative membrane-associated protein 4199155 8193710 METDI4258 Methylobacterium extorquens DM4 putative glycosyl transferase, putative membrane-associated protein YP_003069728.1 4197959 D 661410 CDS YP_003069729.1 254562634 8193711 4199213..4200637 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; Radical SAM superfamily protein 4200637 8193711 METDI4259 Methylobacterium extorquens DM4 Radical SAM superfamily protein YP_003069729.1 4199213 D 661410 CDS YP_003069730.1 254562635 8193712 4200767..4201609 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4201609 8193712 METDI4260 Methylobacterium extorquens DM4 hypothetical protein YP_003069730.1 4200767 D 661410 CDS YP_003069731.1 254562636 8193713 4201852..4202355 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4202355 8193713 METDI4261 Methylobacterium extorquens DM4 hypothetical protein YP_003069731.1 4201852 D 661410 CDS YP_003069732.1 254562637 8193714 complement(4202490..4205138) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative membrane protein with sterol sensing domain; putative exporter, RND family 4205138 8193714 METDI4262 Methylobacterium extorquens DM4 putative membrane protein with sterol sensing domain; putative exporter, RND family YP_003069732.1 4202490 R 661410 CDS YP_003069733.1 254562638 8193715 4205886..4207049 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; Radical SAM superfamily protein 4207049 8193715 METDI4263 Methylobacterium extorquens DM4 Radical SAM superfamily protein YP_003069733.1 4205886 D 661410 CDS YP_003069734.1 254562639 8193716 complement(4207248..4207955) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative nucleoside phosphorylase 4207955 8193716 METDI4264 Methylobacterium extorquens DM4 putative nucleoside phosphorylase YP_003069734.1 4207248 R 661410 CDS YP_003069735.1 254562640 8193717 complement(4207952..4209118) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11373120; Product type pt : putative transporter; putative capsule polysaccharide export outer membrane protein 4209118 8193717 METDI4265 Methylobacterium extorquens DM4 putative capsule polysaccharide export outer membrane protein YP_003069735.1 4207952 R 661410 CDS YP_003069736.1 254562641 8193718 4209424..4209966 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 11468405, 8655507; Product type e : enzyme; gluconokinase; gluconate transport, GNT I system 4209966 gntK 8193718 gntK Methylobacterium extorquens DM4 gluconokinase; gluconate transport, GNT I system YP_003069736.1 4209424 D 661410 CDS YP_003069737.1 254562642 8195526 4209975..4210778 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative hydrolase, Cof-subfamily 4210778 8195526 METDI4267 Methylobacterium extorquens DM4 putative hydrolase, Cof-subfamily YP_003069737.1 4209975 D 661410 CDS YP_003069738.1 254562643 8193719 4211025..4211918 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4211918 8193719 METDI4268 Methylobacterium extorquens DM4 hypothetical protein YP_003069738.1 4211025 D 661410 CDS YP_003069739.1 254562644 8193720 4212076..4212264 1 NC_012988.1 some L32 proteins have zinc finger motifs consisting of CXXC while others do not; 50S ribosomal protein L32 4212264 rpmF 8193720 rpmF Methylobacterium extorquens DM4 50S ribosomal protein L32 YP_003069739.1 4212076 D 661410 CDS YP_003069740.1 254562645 8196040 4212332..4212652 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4212652 8196040 METDI4270 Methylobacterium extorquens DM4 hypothetical protein YP_003069740.1 4212332 D 661410 CDS YP_003069741.1 254562646 8193721 complement(4212816..4213418) 1 NC_012988.1 Evidence 1c : Function experimentally demonstrated in the studied genus; Product type pr : putative regulator; putative regulator for granule-associated proteins, PHB biosynthesis and acetyl-CoA flux 4213418 phaR 8193721 phaR Methylobacterium extorquens DM4 putative regulator for granule-associated proteins, PHB biosynthesis and acetyl-CoA flux YP_003069741.1 4212816 R 661410 CDS YP_003069742.1 254562647 8195857 4213744..4214928 1 NC_012988.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11208803; Product type e : enzyme; beta-ketothiolase 4214928 phaA 8195857 phaA Methylobacterium extorquens DM4 beta-ketothiolase YP_003069742.1 4213744 D 661410 CDS YP_003069743.1 254562648 8195854 4215201..4215929 1 NC_012988.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11208803; Product type e : enzyme; acetoacetyl-CoA reductase 4215929 phaB 8195854 phaB Methylobacterium extorquens DM4 acetoacetyl-CoA reductase YP_003069743.1 4215201 D 661410 CDS YP_003069744.1 254562649 8195855 4216085..4217059 1 NC_012988.1 Acylates the intermediate (KDO)2-lipid IVA to form (KDO)2-(lauroyl)-lipid IVA; lipid A biosynthesis lauroyl acyltransferase 4217059 lpxM 8195855 lpxM Methylobacterium extorquens DM4 lipid A biosynthesis lauroyl acyltransferase YP_003069744.1 4216085 D 661410 CDS YP_003069745.1 254562650 8195651 complement(4217088..4218347) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; aminopeptidase 4218347 8195651 METDI4275 Methylobacterium extorquens DM4 aminopeptidase YP_003069745.1 4217088 R 661410 CDS YP_003069746.1 254562651 8193722 complement(4218425..4218718) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4218718 8193722 METDI4276 Methylobacterium extorquens DM4 hypothetical protein YP_003069746.1 4218425 R 661410 CDS YP_003069747.1 254562652 8193723 complement(4219096..4220547) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative D-lactate dehydrogenase (cytochrome) 4220547 8193723 METDI4277 Methylobacterium extorquens DM4 putative D-lactate dehydrogenase (cytochrome) YP_003069747.1 4219096 R 661410 CDS YP_003069748.1 254562653 8193724 4220755..4221450 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative Fumarylacetoacetate (FAA) hydrolase 4221450 8193724 METDI4278 Methylobacterium extorquens DM4 putative Fumarylacetoacetate (FAA) hydrolase YP_003069748.1 4220755 D 661410 CDS YP_003069749.1 254562654 8193725 4221447..4221974 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; NUDIX superfamily hydrolase 4221974 8193725 METDI4279 Methylobacterium extorquens DM4 NUDIX superfamily hydrolase YP_003069749.1 4221447 D 661410 CDS YP_003069750.1 254562655 8196226 4222420..4223697 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; DegT/DnrJ/EryC1/StrS aminotransferase 4223697 8196226 METDI4280 Methylobacterium extorquens DM4 DegT/DnrJ/EryC1/StrS aminotransferase YP_003069750.1 4222420 D 661410 CDS YP_003069751.1 254562656 8193727 complement(4223853..4224539) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4224539 8193727 METDI4281 Methylobacterium extorquens DM4 hypothetical protein YP_003069751.1 4223853 R 661410 CDS YP_003069752.1 254562657 8193728 4224723..4225772 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative Regulatory protein, LysR family 4225772 8193728 METDI4282 Methylobacterium extorquens DM4 putative Regulatory protein, LysR family YP_003069752.1 4224723 D 661410 CDS YP_003069753.1 254562658 8193729 4226166..4226915 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcriptional regulator, Crp/Fnr family 4226915 8193729 METDI4283 Methylobacterium extorquens DM4 putative transcriptional regulator, Crp/Fnr family YP_003069753.1 4226166 D 661410 CDS YP_003069754.1 254562659 8193730 complement(4227098..4227376) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4227376 8193730 METDI4284 Methylobacterium extorquens DM4 hypothetical protein YP_003069754.1 4227098 R 661410 CDS YP_003069755.1 254562660 8193731 complement(4227469..4227678) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4227678 8193731 METDI4285 Methylobacterium extorquens DM4 hypothetical protein YP_003069755.1 4227469 R 661410 CDS YP_003069756.1 254562661 8193732 4227696..4227959 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4227959 8193732 METDI4286 Methylobacterium extorquens DM4 hypothetical protein YP_003069756.1 4227696 D 661410 CDS YP_003069757.1 254562662 8193733 4228090..4228512 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4228512 8193733 METDI4287 Methylobacterium extorquens DM4 hypothetical protein YP_003069757.1 4228090 D 661410 CDS YP_003069758.1 254562663 8193734 complement(4228613..4229689) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative acyl-CoA dehydrogenase 4229689 8193734 METDI4288 Methylobacterium extorquens DM4 putative acyl-CoA dehydrogenase YP_003069758.1 4228613 R 661410 CDS YP_003069759.1 254562664 8193735 complement(4229695..4230252) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4230252 8193735 METDI4289 Methylobacterium extorquens DM4 hypothetical protein YP_003069759.1 4229695 R 661410 CDS YP_003069760.1 254562665 8193736 complement(4230263..4231120) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative ABC transporter, permease 4231120 8193736 METDI4290 Methylobacterium extorquens DM4 putative ABC transporter, permease YP_003069760.1 4230263 R 661410 CDS YP_003069761.1 254562666 8193737 complement(4231117..4232343) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative ABC transporter, periplasmic protein 4232343 8193737 METDI4291 Methylobacterium extorquens DM4 putative ABC transporter, periplasmic protein YP_003069761.1 4231117 R 661410 CDS YP_003069762.1 254562667 8193738 complement(4232330..4233121) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative ABC transporter, ATPase 4233121 8193738 METDI4292 Methylobacterium extorquens DM4 putative ABC transporter, ATPase YP_003069762.1 4232330 R 661410 CDS YP_003069763.1 254562668 8193739 4233793..4235247 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative carbohydrate-selective porin 4235247 8193739 METDI4293 Methylobacterium extorquens DM4 putative carbohydrate-selective porin YP_003069763.1 4233793 D 661410 CDS YP_003069764.1 254562669 8193740 4235303..4236706 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; Monooxygenase, NtaA/SnaA/SoxA family 4236706 8193740 METDI4294 Methylobacterium extorquens DM4 Monooxygenase, NtaA/SnaA/SoxA family YP_003069764.1 4235303 D 661410 CDS YP_003069765.1 254562670 8193741 4236712..4237482 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type t : transporter; Branched-chain amino acid ABC transporter, ATP-binding protein 4237482 livG 8193741 livG Methylobacterium extorquens DM4 Branched-chain amino acid ABC transporter, ATP-binding protein YP_003069765.1 4236712 D 661410 CDS YP_003069766.1 254562671 8195639 4237493..4238374 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type t : transporter; Branched-chain amino acid ABC transporter, permease protein 4238374 8195639 METDI4296 Methylobacterium extorquens DM4 Branched-chain amino acid ABC transporter, permease protein YP_003069766.1 4237493 D 661410 CDS YP_003069767.1 254562672 8193742 4238379..4239422 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative branched-chain amino acid transport system permease protein 4239422 8193742 METDI4297 Methylobacterium extorquens DM4 putative branched-chain amino acid transport system permease protein YP_003069767.1 4238379 D 661410 CDS YP_003069768.1 254562673 8193743 4239458..4240831 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4240831 8193743 METDI4298 Methylobacterium extorquens DM4 hypothetical protein YP_003069768.1 4239458 D 661410 CDS YP_003069769.1 254562674 8193744 4240828..4241589 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 14702302, 2195019, 90307651; Product type t : transporter; leucine/isoleucine/valine transporter subunit ; ATP-binding component of ABC superfamily 4241589 livF 8193744 livF Methylobacterium extorquens DM4 leucine/isoleucine/valine transporter subunit ; ATP-binding component of ABC superfamily YP_003069769.1 4240828 D 661410 CDS YP_003069770.1 254562675 8195638 4241621..4242883 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 15661012; Product type pe : putative enzyme; acyl-CoA dehydrogenase 4242883 8195638 METDI4300 Methylobacterium extorquens DM4 acyl-CoA dehydrogenase YP_003069770.1 4241621 D 661410 CDS YP_003069771.1 254562676 8193745 4243056..4243343 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4243343 8193745 METDI4301 Methylobacterium extorquens DM4 hypothetical protein YP_003069771.1 4243056 D 661410 CDS YP_003069772.1 254562677 8193746 4243422..4243898 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor; putative molecular chaperone, heat shock Hsp20 family 4243898 8193746 METDI4302 Methylobacterium extorquens DM4 putative molecular chaperone, heat shock Hsp20 family YP_003069772.1 4243422 D 661410 CDS YP_003069773.1 254562678 8193747 4243895..4244770 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcriptional regulator, Crp/Fnr family 4244770 8193747 METDI4303 Methylobacterium extorquens DM4 putative transcriptional regulator, Crp/Fnr family YP_003069773.1 4243895 D 661410 CDS YP_003069774.1 254562679 8193748 4244859..4245671 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor; UspA (universal stress protein) domain protein 4245671 8193748 METDI4304 Methylobacterium extorquens DM4 UspA (universal stress protein) domain protein YP_003069774.1 4244859 D 661410 CDS YP_003069775.1 254562680 8193749 4245816..4246265 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4246265 8193749 METDI4305 Methylobacterium extorquens DM4 hypothetical protein YP_003069775.1 4245816 D 661410 CDS YP_003069776.1 254562681 8193750 complement(4246296..4246622) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4246622 8193750 METDI4306 Methylobacterium extorquens DM4 hypothetical protein YP_003069776.1 4246296 R 661410 CDS YP_003069777.1 254562682 8193751 complement(4246655..4246876) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4246876 8193751 METDI4307 Methylobacterium extorquens DM4 hypothetical protein YP_003069777.1 4246655 R 661410 CDS YP_003069778.1 254562683 8193752 4246854..4247198 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4247198 8193752 METDI4308 Methylobacterium extorquens DM4 hypothetical protein YP_003069778.1 4246854 D 661410 CDS YP_003069779.1 254562684 8193753 4247141..4248001 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4248001 8193753 METDI4309 Methylobacterium extorquens DM4 hypothetical protein YP_003069779.1 4247141 D 661410 CDS YP_003069780.1 254562685 8193754 4247998..4248111 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4248111 8193754 METDI4310 Methylobacterium extorquens DM4 hypothetical protein YP_003069780.1 4247998 D 661410 CDS YP_003069781.1 254562686 8193755 complement(4248119..4248808) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcriptional regulator, Crp/Fnr family 4248808 8193755 METDI4311 Methylobacterium extorquens DM4 putative transcriptional regulator, Crp/Fnr family YP_003069781.1 4248119 R 661410 CDS YP_003069782.1 254562687 8193756 complement(4249347..4249955) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type r : regulator; two component transcriptional regulator, LuxR family; putative nitrogen fixation transcriptional regulator FixJ 4249955 fixJ 8193756 fixJ Methylobacterium extorquens DM4 two component transcriptional regulator, LuxR family; putative nitrogen fixation transcriptional regulator FixJ YP_003069782.1 4249347 R 661410 CDS YP_003069783.1 254562688 8195378 complement(4249959..4251506) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; two component low oxygen sensor histidine kinase with PAS domains, FixL 4251506 fixL 8195378 fixL Methylobacterium extorquens DM4 two component low oxygen sensor histidine kinase with PAS domains, FixL YP_003069783.1 4249959 R 661410 CDS YP_003069784.1 254562689 8195383 4251853..4252713 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4252713 8195383 METDI4314 Methylobacterium extorquens DM4 hypothetical protein YP_003069784.1 4251853 D 661410 CDS YP_003069785.1 254562690 8193757 4252931..4253986 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative metal dependent phosphohydrolase with a response regulator receiver domain; HD-GYP domain protein 4253986 8193757 METDI4315 Methylobacterium extorquens DM4 putative metal dependent phosphohydrolase with a response regulator receiver domain; HD-GYP domain protein YP_003069785.1 4252931 D 661410 CDS YP_003069786.1 254562691 8193758 complement(4254102..4256846) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 1314807; Product type pe : putative enzyme; putative sensor protein gacS (Synonyms : lemA) 4256846 8193758 METDI4316 Methylobacterium extorquens DM4 putative sensor protein gacS (Synonyms : lemA) YP_003069786.1 4254102 R 661410 CDS YP_003069787.1 254562692 8193759 complement(4257014..4258435) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4258435 8193759 METDI4317 Methylobacterium extorquens DM4 hypothetical protein YP_003069787.1 4257014 R 661410 CDS YP_003069788.1 254562693 8193760 complement(4258634..4259242) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4259242 8193760 METDI4318 Methylobacterium extorquens DM4 hypothetical protein YP_003069788.1 4258634 R 661410 CDS YP_003069789.1 254562694 8193761 complement(4259239..4259754) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4259754 8193761 METDI4319 Methylobacterium extorquens DM4 hypothetical protein YP_003069789.1 4259239 R 661410 CDS YP_003069790.1 254562695 8193764 4261602..4261949 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4261949 8193764 METDI4322 Methylobacterium extorquens DM4 hypothetical protein YP_003069790.1 4261602 D 661410 CDS YP_003069791.1 254562696 8193765 4262038..4262274 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4262274 8193765 METDI4323 Methylobacterium extorquens DM4 hypothetical protein YP_003069791.1 4262038 D 661410 CDS YP_003069792.1 254562697 8193766 4262631..4263314 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative nuclease 4263314 8193766 METDI4324 Methylobacterium extorquens DM4 putative nuclease YP_003069792.1 4262631 D 661410 CDS YP_003069793.1 254562698 8193767 4263369..4263635 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4263635 8193767 METDI4325 Methylobacterium extorquens DM4 hypothetical protein YP_003069793.1 4263369 D 661410 CDS YP_003069794.1 254562699 8193768 4263714..4263908 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4263908 8193768 METDI4326 Methylobacterium extorquens DM4 hypothetical protein YP_003069794.1 4263714 D 661410 CDS YP_003069795.1 254562700 8193769 4264257..4265297 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4265297 8193769 METDI4327 Methylobacterium extorquens DM4 hypothetical protein YP_003069795.1 4264257 D 661410 CDS YP_003069796.1 254562701 8193770 complement(4265341..4266672) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 2989816, 2989817; Product type e : enzyme; component of DNA polymerase V, subunit C 4266672 umuC 8193770 umuC Methylobacterium extorquens DM4 component of DNA polymerase V, subunit C YP_003069796.1 4265341 R 661410 CDS YP_003069797.1 254562702 8196300 complement(4266669..4267061) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 2989816; Product type e : enzyme; component of DNA polymerase V, subunit D 4267061 umuD 8196300 umuD Methylobacterium extorquens DM4 component of DNA polymerase V, subunit D YP_003069797.1 4266669 R 661410 CDS YP_003069798.1 254562703 8196302 4267225..4267515 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4267515 8196302 METDI4330 Methylobacterium extorquens DM4 hypothetical protein YP_003069798.1 4267225 D 661410 CDS YP_003069799.1 254562704 8193771 4267782..4267994 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4267994 8193771 METDI4331 Methylobacterium extorquens DM4 hypothetical protein YP_003069799.1 4267782 D 661410 CDS YP_003069800.1 254562705 8193772 complement(4268097..4268387) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4268387 8193772 METDI4332 Methylobacterium extorquens DM4 hypothetical protein YP_003069800.1 4268097 R 661410 CDS YP_003069801.1 254562706 8193773 4268387..4268575 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4268575 8193773 METDI4333 Methylobacterium extorquens DM4 hypothetical protein YP_003069801.1 4268387 D 661410 CDS YP_003069802.1 254562707 8193774 4268800..4269084 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcriptional regulator, XRE family 4269084 8193774 METDI4334 Methylobacterium extorquens DM4 putative transcriptional regulator, XRE family YP_003069802.1 4268800 D 661410 CDS YP_003069803.1 254562708 8193775 complement(4269339..4270580) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4270580 8193775 METDI4336 Methylobacterium extorquens DM4 hypothetical protein YP_003069803.1 4269339 R 661410 CDS YP_003069804.1 254562709 8193778 complement(4272968..4273222) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4273222 8193778 METDI4339 Methylobacterium extorquens DM4 hypothetical protein YP_003069804.1 4272968 R 661410 CDS YP_003069805.1 254562710 8193779 complement(4273950..4274873) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcriptional regulator, LysR family 4274873 8193779 METDI4340 Methylobacterium extorquens DM4 putative transcriptional regulator, LysR family YP_003069805.1 4273950 R 661410 CDS YP_003069806.1 254562711 8193784 4277440..4277628 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4277628 8193784 METDI4345 Methylobacterium extorquens DM4 hypothetical protein YP_003069806.1 4277440 D 661410 CDS YP_003069807.1 254562712 8193785 complement(4277582..4278133) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4278133 8193785 METDI4346 Methylobacterium extorquens DM4 hypothetical protein YP_003069807.1 4277582 R 661410 CDS YP_003069808.1 254562713 8193786 complement(4278287..4278463) 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 4278463 8193786 METDI4347 Methylobacterium extorquens DM4 hypothetical protein YP_003069808.1 4278287 R 661410 CDS YP_003069809.1 254562714 8193787 complement(4278430..4278801) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4278801 8193787 METDI4348 Methylobacterium extorquens DM4 hypothetical protein YP_003069809.1 4278430 R 661410 CDS YP_003069810.1 254562715 8193788 complement(4278820..4279302) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4279302 8193788 METDI4349 Methylobacterium extorquens DM4 hypothetical protein YP_003069810.1 4278820 R 661410 CDS YP_003069811.1 254562716 8193789 complement(4279299..4279658) 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 4279658 8193789 METDI4350 Methylobacterium extorquens DM4 hypothetical protein YP_003069811.1 4279299 R 661410 CDS YP_003069812.1 254562717 8193790 complement(4279702..4280265) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4280265 8193790 METDI4351 Methylobacterium extorquens DM4 hypothetical protein YP_003069812.1 4279702 R 661410 CDS YP_003069813.1 254562718 8193791 complement(4280452..4281150) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4281150 8193791 METDI4352 Methylobacterium extorquens DM4 hypothetical protein YP_003069813.1 4280452 R 661410 CDS YP_003069814.1 254562719 8193792 complement(4281215..4281643) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4281643 8193792 METDI4353 Methylobacterium extorquens DM4 hypothetical protein YP_003069814.1 4281215 R 661410 CDS YP_003069815.1 254562720 8193793 complement(4281682..4282590) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4282590 8193793 METDI4354 Methylobacterium extorquens DM4 hypothetical protein YP_003069815.1 4281682 R 661410 CDS YP_003069816.1 254562721 8193794 4282550..4282960 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 10400574; Product type e : enzyme; Excisionase 4282960 8193794 METDI4355 Methylobacterium extorquens DM4 Excisionase YP_003069816.1 4282550 D 661410 CDS YP_003069817.1 254562722 8193795 4282759..4283718 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; Phage integrase 4283718 8193795 METDI4356 Methylobacterium extorquens DM4 Phage integrase YP_003069817.1 4282759 D 661410 CDS YP_003069818.1 254562723 8193796 complement(4283693..4285018) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; Phage integrase 4285018 8193796 METDI4357 Methylobacterium extorquens DM4 Phage integrase YP_003069818.1 4283693 R 661410 CDS YP_003069819.1 254562724 8193797 complement(4284829..4285281) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 10400574; Product type pe : putative enzyme; hypothetical protein 4285281 8193797 METDI4358 Methylobacterium extorquens DM4 hypothetical protein YP_003069819.1 4284829 R 661410 CDS YP_003069820.1 254562725 8193798 complement(4285372..4286250) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4286250 8193798 METDI4359 Methylobacterium extorquens DM4 hypothetical protein YP_003069820.1 4285372 R 661410 CDS YP_003069821.1 254562726 8193799 complement(4286250..4287056) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4287056 8193799 METDI4360 Methylobacterium extorquens DM4 hypothetical protein YP_003069821.1 4286250 R 661410 CDS YP_003069822.1 254562727 8193800 complement(4287067..4287279) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4287279 8193800 METDI4361 Methylobacterium extorquens DM4 hypothetical protein YP_003069822.1 4287067 R 661410 CDS YP_003069823.1 254562728 8193801 complement(4287231..4288061) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4288061 8193801 METDI4362 Methylobacterium extorquens DM4 hypothetical protein YP_003069823.1 4287231 R 661410 CDS YP_003069824.1 254562729 8193802 complement(4288061..4288273) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4288273 8193802 METDI4363 Methylobacterium extorquens DM4 hypothetical protein YP_003069824.1 4288061 R 661410 CDS YP_003069825.1 254562730 8193803 complement(4288270..4288749) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4288749 8193803 METDI4364 Methylobacterium extorquens DM4 hypothetical protein YP_003069825.1 4288270 R 661410 CDS YP_003069826.1 254562731 8193804 4289035..4289754 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4289754 8193804 METDI4365 Methylobacterium extorquens DM4 hypothetical protein YP_003069826.1 4289035 D 661410 CDS YP_003069827.1 254562732 8193805 4289751..4290680 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; adenine-specific DNA methyltransferase 4290680 8193805 METDI4366 Methylobacterium extorquens DM4 adenine-specific DNA methyltransferase YP_003069827.1 4289751 D 661410 CDS YP_003069828.1 254562733 8193806 complement(4291118..4292527) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4292527 8193806 METDI4367 Methylobacterium extorquens DM4 hypothetical protein YP_003069828.1 4291118 R 661410 CDS YP_003069829.1 254562734 8193807 4292815..4295544 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4295544 8193807 METDI4368 Methylobacterium extorquens DM4 hypothetical protein YP_003069829.1 4292815 D 661410 CDS YP_003069830.1 254562735 8193808 4295541..4296212 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4296212 8193808 METDI4369 Methylobacterium extorquens DM4 hypothetical protein YP_003069830.1 4295541 D 661410 CDS YP_003069831.1 254562736 8193809 complement(4296851..4297093) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4297093 8193809 METDI4370 Methylobacterium extorquens DM4 hypothetical protein YP_003069831.1 4296851 R 661410 CDS YP_003069832.1 254562737 8193810 4297253..4298182 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; transposase of ISMdi4, IS481 family 4298182 8193810 METDI4371 Methylobacterium extorquens DM4 transposase of ISMdi4, IS481 family YP_003069832.1 4297253 D 661410 CDS YP_003069833.1 254562738 8193811 complement(4298187..4298393) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4298393 8193811 METDI4372 Methylobacterium extorquens DM4 hypothetical protein YP_003069833.1 4298187 R 661410 CDS YP_003069834.1 254562739 8193812 complement(4298850..4299455) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4299455 8193812 METDI4373 Methylobacterium extorquens DM4 hypothetical protein YP_003069834.1 4298850 R 661410 CDS YP_003069835.1 254562740 8193813 4299440..4299727 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4299727 8193813 METDI4374 Methylobacterium extorquens DM4 hypothetical protein YP_003069835.1 4299440 D 661410 CDS YP_003069836.1 254562741 8193814 4300210..4300521 1 NC_012988.1 Evidence 6 : Doubtful CDS; Product type e : enzyme; hypothetical protein 4300521 8193814 METDI4375 Methylobacterium extorquens DM4 hypothetical protein YP_003069836.1 4300210 D 661410 CDS YP_003069837.1 254562742 8193815 4300607..4300897 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4300897 8193815 METDI4376 Methylobacterium extorquens DM4 hypothetical protein YP_003069837.1 4300607 D 661410 CDS YP_003069838.1 254562743 8193816 complement(4300703..4300801) 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 4300801 8193816 METDI4377 Methylobacterium extorquens DM4 hypothetical protein YP_003069838.1 4300703 R 661410 CDS YP_003069839.1 254562744 8193817 complement(4301094..4301471) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4301471 8193817 METDI4378 Methylobacterium extorquens DM4 hypothetical protein YP_003069839.1 4301094 R 661410 CDS YP_003069840.1 254562745 8193818 4301671..4301949 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4301949 8193818 METDI4379 Methylobacterium extorquens DM4 hypothetical protein YP_003069840.1 4301671 D 661410 CDS YP_003069841.1 254562746 8193819 complement(4302097..4302396) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4302396 8193819 METDI4380 Methylobacterium extorquens DM4 hypothetical protein YP_003069841.1 4302097 R 661410 CDS YP_003069842.1 254562747 8193820 complement(4302801..4303109) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4303109 8193820 METDI4381 Methylobacterium extorquens DM4 hypothetical protein YP_003069842.1 4302801 R 661410 CDS YP_003069843.1 254562748 8193821 complement(4304681..4305517) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; transposase of ISMex11, IS3 family (ORF 2) 4305517 8193821 METDI4382 Methylobacterium extorquens DM4 transposase of ISMex11, IS3 family (ORF 2) YP_003069843.1 4304681 R 661410 CDS YP_003069844.1 254562749 8193822 complement(4305514..4305780) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; transposase of ISMex11, IS3 family (ORF 1) 4305780 8193822 METDI4383 Methylobacterium extorquens DM4 transposase of ISMex11, IS3 family (ORF 1) YP_003069844.1 4305514 R 661410 CDS YP_003069845.1 254562750 8193823 4305761..4305991 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4305991 8193823 METDI4384 Methylobacterium extorquens DM4 hypothetical protein YP_003069845.1 4305761 D 661410 CDS YP_003069846.1 254562751 8193824 complement(4306359..4306526) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4306526 8193824 METDI4385 Methylobacterium extorquens DM4 hypothetical protein YP_003069846.1 4306359 R 661410 CDS YP_003069847.1 254562752 8193825 complement(4307089..4307232) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4307232 8193825 METDI4387 Methylobacterium extorquens DM4 hypothetical protein YP_003069847.1 4307089 R 661410 CDS YP_003069848.1 254562753 8193826 4307531..4308130 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4308130 8193826 METDI4388 Methylobacterium extorquens DM4 hypothetical protein YP_003069848.1 4307531 D 661410 CDS YP_003069849.1 254562754 8193827 4308232..4308480 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4308480 8193827 METDI4389 Methylobacterium extorquens DM4 hypothetical protein YP_003069849.1 4308232 D 661410 CDS YP_003069850.1 254562755 8193828 complement(4308682..4308948) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4308948 8193828 METDI4390 Methylobacterium extorquens DM4 hypothetical protein YP_003069850.1 4308682 R 661410 CDS YP_003069851.1 254562756 8193829 complement(4309111..4309356) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4309356 8193829 METDI4391 Methylobacterium extorquens DM4 hypothetical protein YP_003069851.1 4309111 R 661410 CDS YP_003069852.1 254562757 8193830 complement(4309611..4309691) 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 4309691 8193830 METDI4392 Methylobacterium extorquens DM4 hypothetical protein YP_003069852.1 4309611 R 661410 CDS YP_003069853.1 254562758 8193831 complement(4309981..4310325) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4310325 8193831 METDI4393 Methylobacterium extorquens DM4 hypothetical protein YP_003069853.1 4309981 R 661410 CDS YP_003069854.1 254562759 8193832 4310445..4311263 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4311263 8193832 METDI4394 Methylobacterium extorquens DM4 hypothetical protein YP_003069854.1 4310445 D 661410 CDS YP_003069855.1 254562760 8193833 complement(4311280..4312209) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; transposase of ISMex17, IS110 family 4312209 8193833 METDI4395 Methylobacterium extorquens DM4 transposase of ISMex17, IS110 family YP_003069855.1 4311280 R 661410 CDS YP_003069856.1 254562761 8193834 complement(4313006..4313908) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; Zinc-containing alcohol dehydrogenase superfamily 4313908 8193834 METDI4396 Methylobacterium extorquens DM4 Zinc-containing alcohol dehydrogenase superfamily YP_003069856.1 4313006 R 661410 CDS YP_003069857.1 254562762 8193835 complement(4314034..4314873) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type c : carrier; NADP oxidoreductase, coenzyme F420-dependent 4314873 8193835 METDI4397 Methylobacterium extorquens DM4 NADP oxidoreductase, coenzyme F420-dependent YP_003069857.1 4314034 R 661410 CDS YP_003069858.1 254562763 8193836 4314874..4315272 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcriptional regulator 4315272 8193836 METDI4398 Methylobacterium extorquens DM4 putative transcriptional regulator YP_003069858.1 4314874 D 661410 CDS YP_003069859.1 254562764 8193837 4316014..4316916 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type e : enzyme; putative N-carbamyl-D-amino acid amidohydrolase 4316916 8193837 METDI4399 Methylobacterium extorquens DM4 putative N-carbamyl-D-amino acid amidohydrolase YP_003069859.1 4316014 D 661410 CDS YP_003069860.1 254562765 8193838 4316974..4318131 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type prc : putative receptor; putative extracellular ligand-binding receptor precursor 4318131 8193838 METDI4400 Methylobacterium extorquens DM4 putative extracellular ligand-binding receptor precursor YP_003069860.1 4316974 D 661410 CDS YP_003069861.1 254562766 8193839 4318162..4319046 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative Branched-chain amino acid ABC transporter, permease protein 4319046 8193839 METDI4401 Methylobacterium extorquens DM4 putative Branched-chain amino acid ABC transporter, permease protein YP_003069861.1 4318162 D 661410 CDS YP_003069862.1 254562767 8193840 4319039..4320892 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative branched-chain amino acid ABC transporter, permease/ATP-binding protein 4320892 8193840 METDI4402 Methylobacterium extorquens DM4 putative branched-chain amino acid ABC transporter, permease/ATP-binding protein YP_003069862.1 4319039 D 661410 CDS YP_003069863.1 254562768 8193841 4320889..4321602 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative leucine/isoleucine/valine transporter subunit (ATP-binding component of ABC superfamily) (livF) 4321602 8193841 METDI4403 Methylobacterium extorquens DM4 putative leucine/isoleucine/valine transporter subunit (ATP-binding component of ABC superfamily) (livF) YP_003069863.1 4320889 D 661410 CDS YP_003069864.1 254562769 8193842 4321599..4322306 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 10567266; Product type e : enzyme; urease gamma (N-terminal) and beta (C-terminal) subunits (urea amidohydrolase gamma/beta subunits) 4322306 ureAB 8193842 ureAB Methylobacterium extorquens DM4 urease gamma (N-terminal) and beta (C-terminal) subunits (urea amidohydrolase gamma/beta subunits) YP_003069864.1 4321599 D 661410 CDS YP_003069865.1 254562770 8196311 4322308..4324023 1 NC_012988.1 ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 ureC (alpha) and 3 ureAB (gamma/beta) subunits; urease subunit alpha 4324023 ureC 8196311 ureC Methylobacterium extorquens DM4 urease subunit alpha YP_003069865.1 4322308 D 661410 CDS YP_003069866.1 254562771 8196316 4324020..4324643 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 15358858, 9125594; Product type e : enzyme; urease accessory protein UreG 4324643 ureG 8196316 ureG Methylobacterium extorquens DM4 urease accessory protein UreG YP_003069866.1 4324020 D 661410 CDS YP_003069867.1 254562772 8196328 4324643..4325485 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 7813887; Product type pf : putative factor; putative urease accessory protein UreD 4325485 8196328 METDI4407 Methylobacterium extorquens DM4 putative urease accessory protein UreD YP_003069867.1 4324643 D 661410 CDS YP_003069868.1 254562773 8193843 4325564..4325980 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type f : factor; urease accessory protein UreE 4325980 ureE 8193843 ureE Methylobacterium extorquens DM4 urease accessory protein UreE YP_003069868.1 4325564 D 661410 CDS YP_003069869.1 254562774 8196321 4325970..4326677 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type f : factor; urease accessory protein UreF 4326677 ureF 8196321 ureF Methylobacterium extorquens DM4 urease accessory protein UreF YP_003069869.1 4325970 D 661410 CDS YP_003069870.1 254562775 8196324 complement(4326683..4327192) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10508151, 2495988; Product type pr : putative regulator; putative aliphatic amidase regulator, AmiR 4327192 8196324 METDI4410 Methylobacterium extorquens DM4 putative aliphatic amidase regulator, AmiR YP_003069870.1 4326683 R 661410 CDS YP_003069871.1 254562776 8193844 complement(4327289..4328368) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10508151, 10708652, 1762155, 1907262, 7813419; Product type pr : putative regulator; putative aliphatic amidase expression-regulating protein, AmiC 4328368 8193844 METDI4411 Methylobacterium extorquens DM4 putative aliphatic amidase expression-regulating protein, AmiC YP_003069871.1 4327289 R 661410 CDS YP_003069872.1 254562777 8193845 4328512..4330068 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative ABC transporter, periplasmic protein 4330068 8193845 METDI4412 Methylobacterium extorquens DM4 putative ABC transporter, periplasmic protein YP_003069872.1 4328512 D 661410 CDS YP_003069873.1 254562778 8193846 4330065..4330340 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 4330340 8193846 METDI4413 Methylobacterium extorquens DM4 hypothetical protein YP_003069873.1 4330065 D 661410 CDS YP_003069874.1 254562779 8193847 4330840..4332339 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; transposase of ISMdi7, IS21 family (ORF 1) 4332339 8193847 METDI4414 Methylobacterium extorquens DM4 transposase of ISMdi7, IS21 family (ORF 1) YP_003069874.1 4330840 D 661410 CDS YP_003069875.1 254562780 8193848 4332336..4333178 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; transposase of ISMdi7, IS21 family (ORF 2) 4333178 8193848 METDI4415 Methylobacterium extorquens DM4 transposase of ISMdi7, IS21 family (ORF 2) YP_003069875.1 4332336 D 661410 CDS YP_003069876.1 254562781 8193849 complement(4333231..4333512) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4333512 8193849 METDI4416 Methylobacterium extorquens DM4 hypothetical protein YP_003069876.1 4333231 R 661410 CDS YP_003069877.1 254562782 8193850 complement(4335445..4335708) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4335708 8193850 METDI4417 Methylobacterium extorquens DM4 hypothetical protein YP_003069877.1 4335445 R 661410 CDS YP_003069878.1 254562783 8193851 complement(4335839..4336102) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4336102 8193851 METDI4419 Methylobacterium extorquens DM4 hypothetical protein YP_003069878.1 4335839 R 661410 CDS YP_003069879.1 254562784 8193853 4336121..4336261 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4336261 8193853 METDI4418 Methylobacterium extorquens DM4 hypothetical protein YP_003069879.1 4336121 D 661410 CDS YP_003069880.1 254562785 8193852 4336379..4336588 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4336588 8193852 METDI4420 Methylobacterium extorquens DM4 hypothetical protein YP_003069880.1 4336379 D 661410 CDS YP_003069881.1 254562786 8193854 complement(4336653..4338422) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4338422 8193854 METDI4421 Methylobacterium extorquens DM4 hypothetical protein YP_003069881.1 4336653 R 661410 CDS YP_003069882.1 254562787 8193855 complement(4338500..4338937) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4338937 8193855 METDI4422 Methylobacterium extorquens DM4 hypothetical protein YP_003069882.1 4338500 R 661410 CDS YP_003069883.1 254562788 8193856 complement(4339014..4339370) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4339370 8193856 METDI4423 Methylobacterium extorquens DM4 hypothetical protein YP_003069883.1 4339014 R 661410 CDS YP_003069884.1 254562789 8193857 complement(4339620..4340816) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative DNA-directed DNA polymerase 4340816 8193857 METDI4424 Methylobacterium extorquens DM4 putative DNA-directed DNA polymerase YP_003069884.1 4339620 R 661410 CDS YP_003069885.1 254562790 8193858 4340873..4341031 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 4341031 8193858 METDI4425 Methylobacterium extorquens DM4 hypothetical protein YP_003069885.1 4340873 D 661410 CDS YP_003069886.1 254562791 8193859 4341062..4341859 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4341859 8193859 METDI4426 Methylobacterium extorquens DM4 hypothetical protein YP_003069886.1 4341062 D 661410 CDS YP_003069887.1 254562792 8193860 4341861..4342121 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4342121 8193860 METDI4427 Methylobacterium extorquens DM4 hypothetical protein YP_003069887.1 4341861 D 661410 CDS YP_003069888.1 254562793 8193861 4342118..4342360 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4342360 8193861 METDI4428 Methylobacterium extorquens DM4 hypothetical protein YP_003069888.1 4342118 D 661410 CDS YP_003069889.1 254562794 8193862 4342357..4342668 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4342668 8193862 METDI4429 Methylobacterium extorquens DM4 hypothetical protein YP_003069889.1 4342357 D 661410 CDS YP_003069890.1 254562795 8193863 4342904..4343815 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative antirepressor protein 4343815 8193863 METDI4430 Methylobacterium extorquens DM4 putative antirepressor protein YP_003069890.1 4342904 D 661410 CDS YP_003069891.1 254562796 8193864 complement(4343867..4344379) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4344379 8193864 METDI4431 Methylobacterium extorquens DM4 hypothetical protein YP_003069891.1 4343867 R 661410 CDS YP_003069892.1 254562797 8193865 4344573..4344767 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4344767 8193865 METDI4432 Methylobacterium extorquens DM4 hypothetical protein YP_003069892.1 4344573 D 661410 CDS YP_003069893.1 254562798 8193866 4344828..4345115 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4345115 8193866 METDI4433 Methylobacterium extorquens DM4 hypothetical protein YP_003069893.1 4344828 D 661410 CDS YP_003069894.1 254562799 8193867 4345144..4345611 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4345611 8193867 METDI4434 Methylobacterium extorquens DM4 hypothetical protein YP_003069894.1 4345144 D 661410 CDS YP_003069895.1 254562800 8193868 4345604..4346041 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4346041 8193868 METDI4435 Methylobacterium extorquens DM4 hypothetical protein YP_003069895.1 4345604 D 661410 CDS YP_003069896.1 254562801 8193870 complement(4346474..4347688) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4347688 8193870 METDI4437 Methylobacterium extorquens DM4 hypothetical protein YP_003069896.1 4346474 R 661410 CDS YP_003069897.1 254562802 8193871 complement(4347915..4348115) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4348115 8193871 METDI4438 Methylobacterium extorquens DM4 hypothetical protein YP_003069897.1 4347915 R 661410 CDS YP_003069898.1 254562803 8193872 complement(4348112..4348459) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative repressor with a ribbon-helix-helix domain 4348459 8193872 METDI4439 Methylobacterium extorquens DM4 putative repressor with a ribbon-helix-helix domain YP_003069898.1 4348112 R 661410 CDS YP_003069899.1 254562804 8193873 complement(4348633..4349367) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4349367 8193873 METDI4440 Methylobacterium extorquens DM4 hypothetical protein YP_003069899.1 4348633 R 661410 CDS YP_003069900.1 254562805 8193874 complement(4349488..4349859) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4349859 8193874 METDI4441 Methylobacterium extorquens DM4 hypothetical protein YP_003069900.1 4349488 R 661410 CDS YP_003069901.1 254562806 8193875 complement(4350093..4351157) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 7750735; Product type pe : putative enzyme; putative transmembrane adenylate/guanylate cyclase 4351157 8193875 METDI4442 Methylobacterium extorquens DM4 putative transmembrane adenylate/guanylate cyclase YP_003069901.1 4350093 R 661410 CDS YP_003069902.1 254562807 8193876 complement(4351210..4351692) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 9851984; Product type f : factor; cytochrome P460 4351692 cyp 8193876 cyp Methylobacterium extorquens DM4 cytochrome P460 YP_003069902.1 4351210 R 661410 CDS YP_003069903.1 254562808 8195247 complement(4351715..4352839) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative alpha/beta hydrolase, putative epoxide hydrolase, tat pathway signal 4352839 8195247 METDI4445 Methylobacterium extorquens DM4 putative alpha/beta hydrolase, putative epoxide hydrolase, tat pathway signal YP_003069903.1 4351715 R 661410 CDS YP_003069904.1 254562809 8193877 4353093..4354718 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative ATP-binding protein with two ATPase domains, ABC transporter related 4354718 8193877 METDI4446 Methylobacterium extorquens DM4 putative ATP-binding protein with two ATPase domains, ABC transporter related YP_003069904.1 4353093 D 661410 CDS YP_003069905.1 254562810 8193878 complement(4354748..4356049) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type prc : putative receptor; putative integral membrane sensor signal transduction histidine kinase precursor 4356049 8193878 METDI4447 Methylobacterium extorquens DM4 putative integral membrane sensor signal transduction histidine kinase precursor YP_003069905.1 4354748 R 661410 CDS YP_003069906.1 254562811 8193879 complement(4356046..4356858) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 10464234, 2845093, 2997120, 3010044, 6292199, 91175693, 92165726, 93287101; Product type r : regulator; DNA-binding response regulator in two-component regulatory system with EnvZ 4356858 ompR 8193879 ompR Methylobacterium extorquens DM4 DNA-binding response regulator in two-component regulatory system with EnvZ YP_003069906.1 4356046 R 661410 CDS YP_003069907.1 254562812 8195808 4357148..4357978 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 8157602, 9642069; Product type e : enzyme; Non-heme haloperoxidase 4357978 8195808 METDI4449 Methylobacterium extorquens DM4 Non-heme haloperoxidase YP_003069907.1 4357148 D 661410 CDS YP_003069908.1 254562813 8193880 complement(4358047..4358952) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcriptional regulator, lysR family protein 4358952 8193880 METDI4450 Methylobacterium extorquens DM4 putative transcriptional regulator, lysR family protein YP_003069908.1 4358047 R 661410 CDS YP_003069909.1 254562814 8193881 4359026..4359799 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; Short-chain dehydrogenase/reductase SDR 4359799 8193881 METDI4451 Methylobacterium extorquens DM4 Short-chain dehydrogenase/reductase SDR YP_003069909.1 4359026 D 661410 CDS YP_003069910.1 254562815 8193882 complement(4359993..4360955) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type f : factor; RNA polymerase sigma factor 4360955 8193882 METDI4452 Methylobacterium extorquens DM4 RNA polymerase sigma factor YP_003069910.1 4359993 R 661410 CDS YP_003069911.1 254562816 8193883 complement(4360942..4361367) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4361367 8193883 METDI4453 Methylobacterium extorquens DM4 hypothetical protein YP_003069911.1 4360942 R 661410 CDS YP_003069912.1 254562817 8193884 complement(4361367..4362152) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4362152 8193884 METDI4454 Methylobacterium extorquens DM4 hypothetical protein YP_003069912.1 4361367 R 661410 CDS YP_003069913.1 254562818 8193885 4362087..4363811 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative Adenylate cyclase 4363811 8193885 METDI4455 Methylobacterium extorquens DM4 putative Adenylate cyclase YP_003069913.1 4362087 D 661410 CDS YP_003069914.1 254562819 8193886 4364191..4365138 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; Beta-lactamase-like 4365138 8193886 METDI4456 Methylobacterium extorquens DM4 Beta-lactamase-like YP_003069914.1 4364191 D 661410 CDS YP_003069915.1 254562820 8193887 4365436..4366206 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; NAD-dependent epimerase/dehydratase:dTDP-4-dehydrorhamnose reductase:NmrA-like 4366206 8193887 METDI4457 Methylobacterium extorquens DM4 NAD-dependent epimerase/dehydratase:dTDP-4-dehydrorhamnose reductase:NmrA-like YP_003069915.1 4365436 D 661410 CDS YP_003069916.1 254562821 8193888 4366219..4366659 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4366659 8193888 METDI4458 Methylobacterium extorquens DM4 hypothetical protein YP_003069916.1 4366219 D 661410 CDS YP_003069917.1 254562822 8193892 complement(4367550..4367945) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4367945 8193892 METDI4462 Methylobacterium extorquens DM4 hypothetical protein YP_003069917.1 4367550 R 661410 CDS YP_003069918.1 254562823 8193893 4368488..4368985 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type r : regulator; transcriptional regulator (MarR family) 4368985 8193893 METDI4463 Methylobacterium extorquens DM4 transcriptional regulator (MarR family) YP_003069918.1 4368488 D 661410 CDS YP_003069919.1 254562824 8193894 4368982..4371012 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; putative efflux transporter permease, aromatic acid exporter family 4371012 8193894 METDI4464 Methylobacterium extorquens DM4 putative efflux transporter permease, aromatic acid exporter family YP_003069919.1 4368982 D 661410 CDS YP_003069920.1 254562825 8193895 4371009..4371218 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4371218 8193895 METDI4465 Methylobacterium extorquens DM4 hypothetical protein YP_003069920.1 4371009 D 661410 CDS YP_003069921.1 254562826 8193896 4371264..4372211 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; putative efflux pump component, secretion protein HlyD family 4372211 8193896 METDI4466 Methylobacterium extorquens DM4 putative efflux pump component, secretion protein HlyD family YP_003069921.1 4371264 D 661410 CDS YP_003069922.1 254562827 8193897 4372272..4373159 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; glyoxalase/bleomycin resistance protein/dihydroxybiphenyl dioxygenase 4373159 8193897 METDI4467 Methylobacterium extorquens DM4 glyoxalase/bleomycin resistance protein/dihydroxybiphenyl dioxygenase YP_003069922.1 4372272 D 661410 CDS YP_003069923.1 254562828 8193898 complement(4373184..4374446) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; peptidase, putative amidohydrolase 4374446 8193898 METDI4468 Methylobacterium extorquens DM4 peptidase, putative amidohydrolase YP_003069923.1 4373184 R 661410 CDS YP_003069924.1 254562829 8193899 complement(4374647..4375276) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; hypothetical protein 4375276 8193899 METDI4469 Methylobacterium extorquens DM4 hypothetical protein YP_003069924.1 4374647 R 661410 CDS YP_003069925.1 254562830 8193900 complement(4375348..4376079) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4376079 8193900 METDI4470 Methylobacterium extorquens DM4 hypothetical protein YP_003069925.1 4375348 R 661410 CDS YP_003069926.1 254562831 8195479 4376832..4377338 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4377338 8195479 METDI4471 Methylobacterium extorquens DM4 hypothetical protein YP_003069926.1 4376832 D 661410 CDS YP_003069927.1 254562832 8193902 4377495..4377944 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 7565093; Product type pr : putative regulator; putative regulator 4377944 8193902 METDI4472 Methylobacterium extorquens DM4 putative regulator YP_003069927.1 4377495 D 661410 CDS YP_003069928.1 254562833 8193903 4378192..4379121 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type cp : cell process; putative universal stress protein (Usp) 4379121 8193903 METDI4473 Methylobacterium extorquens DM4 putative universal stress protein (Usp) YP_003069928.1 4378192 D 661410 CDS YP_003069929.1 254562834 8193904 4379196..4379390 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4379390 8193904 METDI4474 Methylobacterium extorquens DM4 hypothetical protein YP_003069929.1 4379196 D 661410 CDS YP_003069930.1 254562835 8195478 complement(4379652..4382420) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative diguanylate cyclase (GGDEF) /phosphodiesterase (EAL), with PAS sensor, signal transduction histidine kinase and methyl-accepting chemotaxis domains; putative membrane-associated protein precursor 4382420 8195478 METDI4475 Methylobacterium extorquens DM4 putative diguanylate cyclase (GGDEF) /phosphodiesterase (EAL), with PAS sensor, signal transduction histidine kinase and methyl-accepting chemotaxis domains; putative membrane-associated protein precursor YP_003069930.1 4379652 R 661410 CDS YP_003069931.1 254562836 8193906 4382575..4382763 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4382763 8193906 METDI4476 Methylobacterium extorquens DM4 hypothetical protein YP_003069931.1 4382575 D 661410 CDS YP_003069932.1 254562837 8193907 complement(4382847..4383056) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4383056 8193907 METDI4477 Methylobacterium extorquens DM4 hypothetical protein YP_003069932.1 4382847 R 661410 CDS YP_003069933.1 254562838 8193908 complement(4383179..4383406) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcription elongation factor GreA-related 4383406 8193908 METDI4478 Methylobacterium extorquens DM4 putative transcription elongation factor GreA-related YP_003069933.1 4383179 R 661410 CDS YP_003069934.1 254562839 8193909 complement(4384670..4384981) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4384981 8193909 METDI4479 Methylobacterium extorquens DM4 hypothetical protein YP_003069934.1 4384670 R 661410 CDS YP_003069935.1 254562840 8193910 4385032..4386468 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 8841401; Product type e : enzyme; homospermidine synthase 4386468 hss 8193910 hss Methylobacterium extorquens DM4 homospermidine synthase YP_003069935.1 4385032 D 661410 CDS YP_003069936.1 254562841 8195581 4386557..4387735 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative oxidoreductase, putative amine oxidase 4387735 8195581 METDI4481 Methylobacterium extorquens DM4 putative oxidoreductase, putative amine oxidase YP_003069936.1 4386557 D 661410 CDS YP_003069937.1 254562842 8193911 4387735..4388976 1 NC_012988.1 catalyzes the formation of 3-phosphonooxypyruvate and glutamate from O-phospho-L-serine and 2-oxoglutarate; phosphoserine aminotransferase 4388976 serC2 8193911 serC2 Methylobacterium extorquens DM4 phosphoserine aminotransferase YP_003069937.1 4387735 D 661410 CDS YP_003069938.1 254562843 8196112 4389103..4390365 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 10366510, 12013436, 9135121, 9654452; Product type e : enzyme; glutamate dehydrogenase (NAD(P)+) oxidoreductase protein 4390365 gdhA 8196112 gdhA Methylobacterium extorquens DM4 glutamate dehydrogenase (NAD(P)+) oxidoreductase protein YP_003069938.1 4389103 D 661410 CDS YP_003069939.1 254562844 8195481 4390568..4391338 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15601702; Product type pe : putative enzyme; putative pseudouridine synthase, putative 1-deoxy-D-xylulose 5-phosphate reductoisomerase 4391338 8195481 METDI4484 Methylobacterium extorquens DM4 putative pseudouridine synthase, putative 1-deoxy-D-xylulose 5-phosphate reductoisomerase YP_003069939.1 4390568 D 661410 CDS YP_003069940.1 254562845 8193912 4391137..4391871 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 10419959, 10694574, 12211023; Product type e : enzyme; 2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase (MECPS, MECDP-synthase) 4391871 ispF 8193912 ispF Methylobacterium extorquens DM4 2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase (MECPS, MECDP-synthase) YP_003069940.1 4391137 D 661410 CDS YP_003069941.1 254562846 8195610 complement(4392347..4392718) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4392718 8195610 METDI4486 Methylobacterium extorquens DM4 hypothetical protein YP_003069941.1 4392347 R 661410 CDS YP_003069942.1 254562847 8193913 4392854..4393993 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4393993 8193913 METDI4487 Methylobacterium extorquens DM4 hypothetical protein YP_003069942.1 4392854 D 661410 CDS YP_003069943.1 254562848 8193914 complement(4394623..4395567) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 15581575, 9843488; Product type e : enzyme; cystathionine gamma-synthase, PLP-dependent 4395567 metB 8193914 metB Methylobacterium extorquens DM4 cystathionine gamma-synthase, PLP-dependent YP_003069943.1 4394623 R 661410 CDS YP_003069944.1 254562849 8195680 complement(4396017..4396493) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 16885456; Product type r : regulator; transcriptional regulator, rrf2 family 4396493 8195680 METDI4489 Methylobacterium extorquens DM4 transcriptional regulator, rrf2 family YP_003069944.1 4396017 R 661410 CDS YP_003069945.1 254562850 8193915 4396589..4397830 1 NC_012988.1 flavohemoprotein; catalyzes the formation of nitrate from nitric oxide; can also catalyze the reduction of dihydropteridine; nitric oxide dioxygenase 4397830 hmp 8193915 hmp Methylobacterium extorquens DM4 nitric oxide dioxygenase YP_003069945.1 4396589 D 661410 CDS YP_003069946.1 254562851 8195568 4397885..4398328 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative PAS/PAC sensor protein 4398328 8195568 METDI4491 Methylobacterium extorquens DM4 putative PAS/PAC sensor protein YP_003069946.1 4397885 D 661410 CDS YP_003069947.1 254562852 8193916 4398346..4399140 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative 5-formyltetrahydrofolate cyclo-ligase 4399140 8193916 METDI4492 Methylobacterium extorquens DM4 putative 5-formyltetrahydrofolate cyclo-ligase YP_003069947.1 4398346 D 661410 CDS YP_003069948.1 254562853 8193917 4399353..4400045 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcriptional regulator, GntR family 4400045 8193917 METDI4493 Methylobacterium extorquens DM4 putative transcriptional regulator, GntR family YP_003069948.1 4399353 D 661410 CDS YP_003069949.1 254562854 8193920 4400950..4402599 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; transposase of ISMex10, ISL3 family 4402599 8193920 METDI4496 Methylobacterium extorquens DM4 transposase of ISMex10, ISL3 family YP_003069949.1 4400950 D 661410 CDS YP_003069950.1 254562855 8193921 4402643..4402849 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4402849 8193921 METDI4497 Methylobacterium extorquens DM4 hypothetical protein YP_003069950.1 4402643 D 661410 CDS YP_003069951.1 254562856 8193922 complement(4402932..4403456) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 10656595, 11481430, 2013576, 7756693; Product type r : regulator; transcriptional regulator, Ros/MucR family 4403456 8193922 METDI4498 Methylobacterium extorquens DM4 transcriptional regulator, Ros/MucR family YP_003069951.1 4402932 R 661410 CDS YP_003069952.1 254562857 8193923 complement(4403576..4403851) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4403851 8193923 METDI4499 Methylobacterium extorquens DM4 hypothetical protein YP_003069952.1 4403576 R 661410 CDS YP_003069953.1 254562858 8193924 4404036..4404230 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4404230 8193924 METDI4500 Methylobacterium extorquens DM4 hypothetical protein YP_003069953.1 4404036 D 661410 CDS YP_003069954.1 254562859 8193925 4404593..4405054 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15716451; Product type pe : putative enzyme; putative diguanylate cyclase (GGDEF motif) 4405054 8193925 METDI4501 Methylobacterium extorquens DM4 putative diguanylate cyclase (GGDEF motif) YP_003069954.1 4404593 D 661410 CDS YP_003069955.1 254562860 8193926 complement(4405190..4406002) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 7619830; Product type pc : putative carrier; putative cytochrome c 4406002 8193926 METDI4502 Methylobacterium extorquens DM4 putative cytochrome c YP_003069955.1 4405190 R 661410 CDS YP_003069956.1 254562861 8193927 complement(4405999..4407621) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10775261; Product type pe : putative enzyme; putative Cytochrome c oxidase, subunit I 4407621 8193927 METDI4503 Methylobacterium extorquens DM4 putative Cytochrome c oxidase, subunit I YP_003069956.1 4405999 R 661410 CDS YP_003069957.1 254562862 8193928 complement(4407611..4408174) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10775261; Product type pe : putative enzyme; putative Cytochrome c oxidase, subunit II 4408174 8193928 METDI4504 Methylobacterium extorquens DM4 putative Cytochrome c oxidase, subunit II YP_003069957.1 4407611 R 661410 CDS YP_003069958.1 254562863 8193929 complement(4408187..4408363) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4408363 8193929 METDI4505 Methylobacterium extorquens DM4 hypothetical protein YP_003069958.1 4408187 R 661410 CDS YP_003069959.1 254562864 8193930 complement(4408368..4409639) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 9352901; Product type pc : putative carrier; putative cytochrome c, putative exported protein 4409639 8193930 METDI4506 Methylobacterium extorquens DM4 putative cytochrome c, putative exported protein YP_003069959.1 4408368 R 661410 CDS YP_003069960.1 254562865 8193931 complement(4409636..4410235) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier; putative cytochrome c 4410235 8193931 METDI4507 Methylobacterium extorquens DM4 putative cytochrome c YP_003069960.1 4409636 R 661410 CDS YP_003069961.1 254562866 8193932 4410803..4411414 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8759861; Product type pr : putative regulator; putative nitric oxide responsive transcriptional regulator NnrR, Crp/Fnr family 4411414 8193932 METDI4508 Methylobacterium extorquens DM4 putative nitric oxide responsive transcriptional regulator NnrR, Crp/Fnr family YP_003069961.1 4410803 D 661410 CDS YP_003069962.1 254562867 8193933 4411616..4411852 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4411852 8193933 METDI4509 Methylobacterium extorquens DM4 hypothetical protein YP_003069962.1 4411616 D 661410 CDS YP_003069963.1 254562868 8193934 complement(4411838..4412053) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4412053 8193934 METDI4510 Methylobacterium extorquens DM4 hypothetical protein YP_003069963.1 4411838 R 661410 CDS YP_003069964.1 254562869 8193935 complement(4412135..4412407) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4412407 8193935 METDI4511 Methylobacterium extorquens DM4 hypothetical protein YP_003069964.1 4412135 R 661410 CDS YP_003069965.1 254562870 8193936 4412388..4412654 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; transposase of ISMex11, IS3 family (ORF 1) 4412654 8193936 METDI4512 Methylobacterium extorquens DM4 transposase of ISMex11, IS3 family (ORF 1) YP_003069965.1 4412388 D 661410 CDS YP_003069966.1 254562871 8193937 4412651..4413487 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; transposase of ISMex11, IS3 family (ORF 2) 4413487 8193937 METDI4513 Methylobacterium extorquens DM4 transposase of ISMex11, IS3 family (ORF 2) YP_003069966.1 4412651 D 661410 CDS YP_003069967.1 254562872 8193938 complement(4413995..4415275) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative transporter, SulP family 4415275 8193938 METDI4514 Methylobacterium extorquens DM4 putative transporter, SulP family YP_003069967.1 4413995 R 661410 CDS YP_003069968.1 254562873 8193939 4416003..4417028 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; Histone deacetylase family protein 4417028 8193939 METDI4515 Methylobacterium extorquens DM4 Histone deacetylase family protein YP_003069968.1 4416003 D 661410 CDS YP_003069969.1 254562874 8193940 complement(4417331..4417780) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4417780 8193940 METDI4517 Methylobacterium extorquens DM4 hypothetical protein YP_003069969.1 4417331 R 661410 CDS YP_003069970.1 254562875 8193941 4418162..4418641 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor; putative molecular chaperone, heat shock Hsp20 family 4418641 8193941 METDI4519 Methylobacterium extorquens DM4 putative molecular chaperone, heat shock Hsp20 family YP_003069970.1 4418162 D 661410 CDS YP_003069971.1 254562876 8193942 4418641..4419498 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcriptional regulator, Crp/Fnr family 4419498 8193942 METDI4520 Methylobacterium extorquens DM4 putative transcriptional regulator, Crp/Fnr family YP_003069971.1 4418641 D 661410 CDS YP_003069972.1 254562877 8193943 complement(4419524..4420342) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor; UspA domain protein, putative universal stress response protein 4420342 8193943 METDI4521 Methylobacterium extorquens DM4 UspA domain protein, putative universal stress response protein YP_003069972.1 4419524 R 661410 CDS YP_003069973.1 254562878 8193946 complement(4421403..4421780) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4421780 8193946 METDI4525 Methylobacterium extorquens DM4 hypothetical protein YP_003069973.1 4421403 R 661410 CDS YP_003069974.1 254562879 8193947 complement(4421777..4422154) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4422154 8193947 METDI4526 Methylobacterium extorquens DM4 hypothetical protein YP_003069974.1 4421777 R 661410 CDS YP_003069975.1 254562880 8193948 complement(4422222..4422461) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor; putative biotin/lipoyl attachment domain 4422461 8193948 METDI4527 Methylobacterium extorquens DM4 putative biotin/lipoyl attachment domain YP_003069975.1 4422222 R 661410 CDS YP_003069976.1 254562881 8193949 4422656..4423174 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4423174 8193949 METDI4528 Methylobacterium extorquens DM4 hypothetical protein YP_003069976.1 4422656 D 661410 CDS YP_003069977.1 254562882 8193950 4423258..4423473 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4423473 8193950 METDI4530 Methylobacterium extorquens DM4 hypothetical protein YP_003069977.1 4423258 D 661410 CDS YP_003069978.1 254562883 8193952 4423484..4423741 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4423741 8193952 METDI4529 Methylobacterium extorquens DM4 hypothetical protein YP_003069978.1 4423484 D 661410 CDS YP_003069979.1 254562884 8193951 4423738..4425069 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative Manganese transport protein mntH 4425069 8193951 METDI4531 Methylobacterium extorquens DM4 putative Manganese transport protein mntH YP_003069979.1 4423738 D 661410 CDS YP_003069980.1 254562885 8193953 4425135..4425587 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4425587 8193953 METDI4532 Methylobacterium extorquens DM4 hypothetical protein YP_003069980.1 4425135 D 661410 CDS YP_003069981.1 254562886 8193954 4425637..4426284 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; hypothetical protein 4426284 8193954 METDI4534 Methylobacterium extorquens DM4 hypothetical protein YP_003069981.1 4425637 D 661410 CDS YP_003069982.1 254562887 8193955 4426370..4427179 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier; putative Universal stress protein, UspA 4427179 8193955 METDI4535 Methylobacterium extorquens DM4 putative Universal stress protein, UspA YP_003069982.1 4426370 D 661410 CDS YP_003069983.1 254562888 8193956 4427222..4427455 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4427455 8193956 METDI4536 Methylobacterium extorquens DM4 hypothetical protein YP_003069983.1 4427222 D 661410 CDS YP_003069984.1 254562889 8193957 complement(4427521..4428180) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4428180 8193957 METDI4537 Methylobacterium extorquens DM4 hypothetical protein YP_003069984.1 4427521 R 661410 CDS YP_003069985.1 254562890 8193958 complement(4428398..4428730) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative cytochrome c, class I 4428730 8193958 METDI4538 Methylobacterium extorquens DM4 putative cytochrome c, class I YP_003069985.1 4428398 R 661410 CDS YP_003069986.1 254562891 8193959 complement(4428730..4429545) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor; putative universal stress protein, UspA-like 4429545 8193959 METDI4539 Methylobacterium extorquens DM4 putative universal stress protein, UspA-like YP_003069986.1 4428730 R 661410 CDS YP_003069987.1 254562892 8193960 complement(4429667..4430650) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative Zn-containing alcohol dehydrogenase (adh) 4430650 8193960 METDI4540 Methylobacterium extorquens DM4 putative Zn-containing alcohol dehydrogenase (adh) YP_003069987.1 4429667 R 661410 CDS YP_003069988.1 254562893 8193961 complement(4430660..4431307) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4431307 8193961 METDI4541 Methylobacterium extorquens DM4 hypothetical protein YP_003069988.1 4430660 R 661410 CDS YP_003069989.1 254562894 8193962 complement(4431337..4431537) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4431537 8193962 METDI4542 Methylobacterium extorquens DM4 hypothetical protein YP_003069989.1 4431337 R 661410 CDS YP_003069990.1 254562895 8193963 4431665..4434211 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 11292814, 11823225; Product type e : enzyme; putative phosphoketolase 4434211 xfp 8193963 xfp Methylobacterium extorquens DM4 putative phosphoketolase YP_003069990.1 4431665 D 661410 CDS YP_003069991.1 254562896 8196341 4434359..4435222 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative acetate kinase (partial) 4435222 8196341 METDI4544 Methylobacterium extorquens DM4 putative acetate kinase (partial) YP_003069991.1 4434359 D 661410 CDS YP_003069992.1 254562897 8193964 4435427..4435915 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4435915 8193964 METDI4545 Methylobacterium extorquens DM4 hypothetical protein YP_003069992.1 4435427 D 661410 CDS YP_003069993.1 254562898 8193965 4435958..4436704 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type t : transporter; aquaporin 4436704 aqpZ 8193965 aqpZ Methylobacterium extorquens DM4 aquaporin YP_003069993.1 4435958 D 661410 CDS YP_003069994.1 254562899 8195080 complement(4436754..4436930) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4436930 8195080 METDI4547 Methylobacterium extorquens DM4 hypothetical protein YP_003069994.1 4436754 R 661410 CDS YP_003069995.1 254562900 8193966 complement(4436927..4437415) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4437415 8193966 METDI4548 Methylobacterium extorquens DM4 hypothetical protein YP_003069995.1 4436927 R 661410 CDS YP_003069996.1 254562901 8193967 complement(4437427..4438077) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4438077 8193967 METDI4549 Methylobacterium extorquens DM4 hypothetical protein YP_003069996.1 4437427 R 661410 CDS YP_003069997.1 254562902 8193968 complement(4438130..4438474) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4438474 8193968 METDI4550 Methylobacterium extorquens DM4 hypothetical protein YP_003069997.1 4438130 R 661410 CDS YP_003069998.1 254562903 8193969 4438632..4439018 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4439018 8193969 METDI4551 Methylobacterium extorquens DM4 hypothetical protein YP_003069998.1 4438632 D 661410 CDS YP_003069999.1 254562904 8193970 4439265..4439660 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4439660 8193970 METDI4552 Methylobacterium extorquens DM4 hypothetical protein YP_003069999.1 4439265 D 661410 CDS YP_003070000.1 254562905 8193971 4439657..4439884 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4439884 8193971 METDI4553 Methylobacterium extorquens DM4 hypothetical protein YP_003070000.1 4439657 D 661410 CDS YP_003070001.1 254562906 8193972 4440013..4442757 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative cation-transporting ATPase 4442757 8193972 METDI4554 Methylobacterium extorquens DM4 putative cation-transporting ATPase YP_003070001.1 4440013 D 661410 CDS YP_003070002.1 254562907 8193973 4442865..4443725 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4443725 8193973 METDI4555 Methylobacterium extorquens DM4 hypothetical protein YP_003070002.1 4442865 D 661410 CDS YP_003070003.1 254562908 8193974 complement(4444067..4444753) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcriptional regulator, Crp/Fnr family [ 4444753 fixK2 8193974 fixK2 Methylobacterium extorquens DM4 putative transcriptional regulator, Crp/Fnr family [ YP_003070003.1 4444067 R 661410 CDS YP_003070004.1 254562909 8195381 complement(4444877..4445101) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4445101 8195381 METDI4557 Methylobacterium extorquens DM4 hypothetical protein YP_003070004.1 4444877 R 661410 CDS YP_003070005.1 254562910 8193975 4445285..4445602 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4445602 8193975 METDI4558 Methylobacterium extorquens DM4 hypothetical protein YP_003070005.1 4445285 D 661410 CDS YP_003070006.1 254562911 8193976 4445662..4446054 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4446054 8193976 METDI4559 Methylobacterium extorquens DM4 hypothetical protein YP_003070006.1 4445662 D 661410 CDS YP_003070007.1 254562912 8193977 complement(4446195..4446584) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12597275, 2000090, 7968919, 9748464; Product type pr : putative regulator; putative two component response regulator (FixJ domain-like) 4446584 8193977 METDI4560 Methylobacterium extorquens DM4 putative two component response regulator (FixJ domain-like) YP_003070007.1 4446195 R 661410 CDS YP_003070008.1 254562913 8193978 complement(4446674..4447282) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 12597275, 2000090; Product type r : regulator; two component transcriptional regulator, LuxR family; putative nitrogen fixation transcriptional regulator FixJ 4447282 fixJ 8193978 fixJ Methylobacterium extorquens DM4 two component transcriptional regulator, LuxR family; putative nitrogen fixation transcriptional regulator FixJ YP_003070008.1 4446674 R 661410 CDS YP_003070009.1 254562914 8195379 complement(4447272..4448822) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; two component low oxygen sensor histidine kinase with PAS domains; FixL 4448822 fixL 8195379 fixL Methylobacterium extorquens DM4 two component low oxygen sensor histidine kinase with PAS domains; FixL YP_003070009.1 4447272 R 661410 CDS YP_003070010.1 254562915 8195384 4449145..4450005 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4450005 8195384 METDI4563 Methylobacterium extorquens DM4 hypothetical protein YP_003070010.1 4449145 D 661410 CDS YP_003070011.1 254562916 8193979 complement(4450321..4450650) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative cytochrome c, class I 4450650 8193979 METDI4564 Methylobacterium extorquens DM4 putative cytochrome c, class I YP_003070011.1 4450321 R 661410 CDS YP_003070012.1 254562917 8193980 complement(4450650..4451462) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier; putative Universal stress protein, UspA 4451462 8193980 METDI4565 Methylobacterium extorquens DM4 putative Universal stress protein, UspA YP_003070012.1 4450650 R 661410 CDS YP_003070013.1 254562918 8193981 complement(4451557..4453479) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type t : transporter; Cation-transporting ATPase 4453479 8193981 METDI4566 Methylobacterium extorquens DM4 Cation-transporting ATPase YP_003070013.1 4451557 R 661410 CDS YP_003070014.1 254562919 8193982 complement(4453999..4454364) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4454364 8193982 METDI4567 Methylobacterium extorquens DM4 hypothetical protein YP_003070014.1 4453999 R 661410 CDS YP_003070015.1 254562920 8193983 4454661..4454996 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4454996 8193983 METDI4569 Methylobacterium extorquens DM4 hypothetical protein YP_003070015.1 4454661 D 661410 CDS YP_003070016.1 254562921 8196244 complement(4455951..4456880) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; transposase of ISMex17, IS110 family 4456880 8196244 METDI4570 Methylobacterium extorquens DM4 transposase of ISMex17, IS110 family YP_003070016.1 4455951 R 661410 CDS YP_003070017.1 254562922 8193985 complement(4457245..4457457) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4457457 8193985 METDI4571 Methylobacterium extorquens DM4 hypothetical protein YP_003070017.1 4457245 R 661410 CDS YP_003070018.1 254562923 8193986 complement(4457695..4457946) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4457946 8193986 METDI4572 Methylobacterium extorquens DM4 hypothetical protein YP_003070018.1 4457695 R 661410 CDS YP_003070019.1 254562924 8193987 4457945..4458163 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4458163 8193987 METDI4573 Methylobacterium extorquens DM4 hypothetical protein YP_003070019.1 4457945 D 661410 CDS YP_003070020.1 254562925 8193988 4458160..4458483 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4458483 8193988 METDI4574 Methylobacterium extorquens DM4 hypothetical protein YP_003070020.1 4458160 D 661410 CDS YP_003070021.1 254562926 8193989 complement(4458579..4459625) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4459625 8193989 METDI4575 Methylobacterium extorquens DM4 hypothetical protein YP_003070021.1 4458579 R 661410 CDS YP_003070022.1 254562927 8193990 complement(4459770..4460477) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4460477 8193990 METDI4576 Methylobacterium extorquens DM4 hypothetical protein YP_003070022.1 4459770 R 661410 CDS YP_003070023.1 254562928 8193991 complement(4460570..4461274) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4461274 8193991 METDI4577 Methylobacterium extorquens DM4 hypothetical protein YP_003070023.1 4460570 R 661410 CDS YP_003070024.1 254562929 8193992 4461664..4462026 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4462026 8193992 METDI4578 Methylobacterium extorquens DM4 hypothetical protein YP_003070024.1 4461664 D 661410 CDS YP_003070025.1 254562930 8193993 4462178..4462423 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4462423 8193993 METDI4579 Methylobacterium extorquens DM4 hypothetical protein YP_003070025.1 4462178 D 661410 CDS YP_003070026.1 254562931 8193994 4462750..4462989 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4462989 8193994 METDI4580 Methylobacterium extorquens DM4 hypothetical protein YP_003070026.1 4462750 D 661410 CDS YP_003070027.1 254562932 8193995 4463289..4463744 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4463744 8193995 METDI4581 Methylobacterium extorquens DM4 hypothetical protein YP_003070027.1 4463289 D 661410 CDS YP_003070028.1 254562933 8193996 4464196..4464495 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4464495 8193996 METDI4582 Methylobacterium extorquens DM4 hypothetical protein YP_003070028.1 4464196 D 661410 CDS YP_003070029.1 254562934 8193997 complement(4464663..4464854) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4464854 8193997 METDI4583 Methylobacterium extorquens DM4 hypothetical protein YP_003070029.1 4464663 R 661410 CDS YP_003070030.1 254562935 8193998 4465028..4465234 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4465234 8193998 METDI4584 Methylobacterium extorquens DM4 hypothetical protein YP_003070030.1 4465028 D 661410 CDS YP_003070031.1 254562936 8193999 complement(4465285..4465488) 1 NC_012988.1 Evidence 6 : Doubtful CDS; Product type h : extrachromosomal origin; hypothetical protein 4465488 8193999 METDI4585 Methylobacterium extorquens DM4 hypothetical protein YP_003070031.1 4465285 R 661410 CDS YP_003070032.1 254562937 8194000 complement(4465590..4465898) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4465898 8194000 METDI4586 Methylobacterium extorquens DM4 hypothetical protein YP_003070032.1 4465590 R 661410 CDS YP_003070033.1 254562938 8194001 complement(4465967..4466434) 1 NC_012988.1 Transcriptional regulator that represses the manganese transporter MntH when manganese is present; manganese transport regulator MntR 4466434 mntR 8194001 mntR Methylobacterium extorquens DM4 manganese transport regulator MntR YP_003070033.1 4465967 R 661410 CDS YP_003070034.1 254562939 8195701 4466852..4468186 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 10712688, 10844693, 20177822, 20305051; Product type t : transporter; manganese transport protein mntH 4468186 mntH 8195701 mntH Methylobacterium extorquens DM4 manganese transport protein mntH YP_003070034.1 4466852 D 661410 CDS YP_003070035.1 254562940 8195700 complement(4468199..4469089) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type r : regulator; transcriptional regulator, LysR family 4469089 8195700 METDI4589 Methylobacterium extorquens DM4 transcriptional regulator, LysR family YP_003070035.1 4468199 R 661410 CDS YP_003070036.1 254562941 8194002 4469266..4470591 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type t : transporter; Sodium/sulphate symporter 4470591 8194002 METDI4590 Methylobacterium extorquens DM4 Sodium/sulphate symporter YP_003070036.1 4469266 D 661410 CDS YP_003070037.1 254562942 8194003 4470719..4471120 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 12730156; Product type e : enzyme; succinate dehydrogenase, cytochrome b556 subunit 4471120 sdhC 8194003 sdhC Methylobacterium extorquens DM4 succinate dehydrogenase, cytochrome b556 subunit YP_003070037.1 4470719 D 661410 CDS YP_003070038.1 254562943 8196103 4471129..4471548 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 12730156; Product type e : enzyme; succinate dehydrogenase, membrane anchor subunit 4471548 sdhD 8196103 sdhD Methylobacterium extorquens DM4 succinate dehydrogenase, membrane anchor subunit YP_003070038.1 4471129 D 661410 CDS YP_003070039.1 254562944 8196104 4471578..4473395 1 NC_012988.1 part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; succinate dehydrogenase flavoprotein subunit 4473395 sdhA 8196104 sdhA Methylobacterium extorquens DM4 succinate dehydrogenase flavoprotein subunit YP_003070039.1 4471578 D 661410 CDS YP_003070040.1 254562945 8196101 4474057..4474881 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 12730156; Product type e : enzyme; succinate dehydrogenase, iron-sulfur subunit 4474881 sdhB 8196101 sdhB Methylobacterium extorquens DM4 succinate dehydrogenase, iron-sulfur subunit YP_003070040.1 4474057 D 661410 CDS YP_003070041.1 254562946 8196102 4475125..4475685 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4475685 8196102 METDI4596 Methylobacterium extorquens DM4 hypothetical protein YP_003070041.1 4475125 D 661410 CDS YP_003070042.1 254562947 8194004 complement(4475690..4477462) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4477462 8194004 METDI4597 Methylobacterium extorquens DM4 hypothetical protein YP_003070042.1 4475690 R 661410 CDS YP_003070043.1 254562948 8194005 4477722..4478744 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 12805358; Product type e : enzyme; Arabinose-5-phosphate isomerase 4478744 kdsD 8194005 kdsD Methylobacterium extorquens DM4 Arabinose-5-phosphate isomerase YP_003070043.1 4477722 D 661410 CDS YP_003070044.1 254562949 8195621 complement(4482625..4483068) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4483068 8195621 METDI4599 Methylobacterium extorquens DM4 hypothetical protein YP_003070044.1 4482625 R 661410 CDS YP_003070045.1 254562950 8194006 4483500..4484264 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 1743516; Product type e : enzyme; Enoyl-CoA hydratase/isomerase family protein 4484264 8194006 METDI4600 Methylobacterium extorquens DM4 Enoyl-CoA hydratase/isomerase family protein YP_003070045.1 4483500 D 661410 CDS YP_003070046.1 254562951 8194007 4484306..4485124 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative short-chain dehydrogenase/reductase SDR 4485124 8194007 METDI4601 Methylobacterium extorquens DM4 putative short-chain dehydrogenase/reductase SDR YP_003070046.1 4484306 D 661410 CDS YP_003070047.1 254562952 8194008 4485121..4485975 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; Short-chain dehydrogenase/reductase SDR 4485975 8194008 METDI4602 Methylobacterium extorquens DM4 Short-chain dehydrogenase/reductase SDR YP_003070047.1 4485121 D 661410 CDS YP_003070048.1 254562953 8194009 4486001..4487005 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative magnesium/cobalt transport protein 4487005 8194009 METDI4603 Methylobacterium extorquens DM4 putative magnesium/cobalt transport protein YP_003070048.1 4486001 D 661410 CDS YP_003070049.1 254562954 8194010 4487216..4487758 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4487758 8194010 METDI4604 Methylobacterium extorquens DM4 hypothetical protein YP_003070049.1 4487216 D 661410 CDS YP_003070050.1 254562955 8194011 complement(4487915..4488088) 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 4488088 8194011 METDI4605 Methylobacterium extorquens DM4 hypothetical protein YP_003070050.1 4487915 R 661410 CDS YP_003070051.1 254562956 8194012 4488264..4489961 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type r : regulator; methyl-accepting chemotaxis sensory transducer 4489961 8194012 METDI4606 Methylobacterium extorquens DM4 methyl-accepting chemotaxis sensory transducer YP_003070051.1 4488264 D 661410 CDS YP_003070052.1 254562957 8194013 complement(4490063..4490344) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4490344 8194013 METDI4607 Methylobacterium extorquens DM4 hypothetical protein YP_003070052.1 4490063 R 661410 CDS YP_003070053.1 254562958 8194014 4490941..4491279 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4491279 8194014 METDI4608 Methylobacterium extorquens DM4 hypothetical protein YP_003070053.1 4490941 D 661410 CDS YP_003070054.1 254562959 8194015 complement(4491470..4491721) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4491721 8194015 METDI4609 Methylobacterium extorquens DM4 hypothetical protein YP_003070054.1 4491470 R 661410 CDS YP_003070055.1 254562960 8194016 complement(4492027..4492425) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4492425 8194016 METDI4610 Methylobacterium extorquens DM4 hypothetical protein YP_003070055.1 4492027 R 661410 CDS YP_003070056.1 254562961 8194017 4492530..4493378 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcriptional regulator, LysR family 4493378 8194017 METDI4611 Methylobacterium extorquens DM4 putative transcriptional regulator, LysR family YP_003070056.1 4492530 D 661410 CDS YP_003070057.1 254562962 8194018 4493576..4493770 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4493770 8194018 METDI4612 Methylobacterium extorquens DM4 hypothetical protein YP_003070057.1 4493576 D 661410 CDS YP_003070058.1 254562963 8194019 4493755..4495830 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative hybrid histidine kinase: Domains: GAF, Histidine Kinase, ATPase and CheY-like 4495830 8194019 METDI4613 Methylobacterium extorquens DM4 putative hybrid histidine kinase: Domains: GAF, Histidine Kinase, ATPase and CheY-like YP_003070058.1 4493755 D 661410 CDS YP_003070059.1 254562964 8194020 4496047..4496565 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4496565 8194020 METDI4614 Methylobacterium extorquens DM4 hypothetical protein YP_003070059.1 4496047 D 661410 CDS YP_003070060.1 254562965 8194021 4496677..4497183 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4497183 8194021 METDI4615 Methylobacterium extorquens DM4 hypothetical protein YP_003070060.1 4496677 D 661410 CDS YP_003070061.1 254562966 8194022 4497249..4497965 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11557893; Product type pe : putative enzyme; putative Endonuclease III (DNA-(apurinic or apyrimidinic site) lyase) 4497965 8194022 METDI4616 Methylobacterium extorquens DM4 putative Endonuclease III (DNA-(apurinic or apyrimidinic site) lyase) YP_003070061.1 4497249 D 661410 CDS YP_003070062.1 254562967 8194023 complement(4498074..4498994) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; Short-chain dehydrogenase/reductase SDR 4498994 8194023 METDI4617 Methylobacterium extorquens DM4 Short-chain dehydrogenase/reductase SDR YP_003070062.1 4498074 R 661410 CDS YP_003070063.1 254562968 8194024 4499118..4499690 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4499690 8194024 METDI4618 Methylobacterium extorquens DM4 hypothetical protein YP_003070063.1 4499118 D 661410 CDS YP_003070064.1 254562969 8194025 4499937..4500773 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 7632719, 8344520; Product type e : enzyme; non-heme haloperoxidase 4500773 8194025 METDI4619 Methylobacterium extorquens DM4 non-heme haloperoxidase YP_003070064.1 4499937 D 661410 CDS YP_003070065.1 254562970 8194026 complement(4500794..4501285) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4501285 8194026 METDI4620 Methylobacterium extorquens DM4 hypothetical protein YP_003070065.1 4500794 R 661410 CDS YP_003070066.1 254562971 8194027 complement(4501478..4501675) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4501675 8194027 METDI4621 Methylobacterium extorquens DM4 hypothetical protein YP_003070066.1 4501478 R 661410 CDS YP_003070067.1 254562972 8194028 4501688..4502206 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4502206 8194028 METDI4622 Methylobacterium extorquens DM4 hypothetical protein YP_003070067.1 4501688 D 661410 CDS YP_003070068.1 254562973 8194029 4502267..4502485 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 8392137; hypothetical protein 4502485 8194029 METDI4623 Methylobacterium extorquens DM4 hypothetical protein YP_003070068.1 4502267 D 661410 CDS YP_003070069.1 254562974 8194030 4502727..4502960 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4502960 8194030 METDI4624 Methylobacterium extorquens DM4 hypothetical protein YP_003070069.1 4502727 D 661410 CDS YP_003070070.1 254562975 8194031 4502966..4503214 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4503214 8194031 METDI4625 Methylobacterium extorquens DM4 hypothetical protein YP_003070070.1 4502966 D 661410 CDS YP_003070071.1 254562976 8194032 4503300..4504025 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 7665460, 8564363; Product type t : transporter; molybdate transporter, membrane component of ABC transporter 4504025 modB 8194032 modB Methylobacterium extorquens DM4 molybdate transporter, membrane component of ABC transporter YP_003070071.1 4503300 D 661410 CDS YP_003070072.1 254562977 8195711 4504248..4504628 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; Product type pt : putative transporter; hypothetical protein 4504628 8195711 METDI4627 Methylobacterium extorquens DM4 hypothetical protein YP_003070072.1 4504248 D 661410 CDS YP_003070073.1 254562978 8194033 complement(4504701..4505357) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative glutathione S-transferase 4505357 8194033 METDI4628 Methylobacterium extorquens DM4 putative glutathione S-transferase YP_003070073.1 4504701 R 661410 CDS YP_003070074.1 254562979 8194034 4505620..4506714 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 7665518, 8384683; Product type t : transporter; molybdate transporter, ATP-binding component of ABC transporter 4506714 modC 8194034 modC Methylobacterium extorquens DM4 molybdate transporter, ATP-binding component of ABC transporter YP_003070074.1 4505620 D 661410 CDS YP_003070075.1 254562980 8195714 4507349..4507978 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4507978 8195714 METDI4630 Methylobacterium extorquens DM4 hypothetical protein YP_003070075.1 4507349 D 661410 CDS YP_003070076.1 254562981 8194035 4508002..4509051 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; 4-hydroxythreonine-4-phosphate dehydrogenase (4-(phosphohydroxy)-L-threonine dehydrogenase) 4509051 pdxA 8194035 pdxA Methylobacterium extorquens DM4 4-hydroxythreonine-4-phosphate dehydrogenase (4-(phosphohydroxy)-L-threonine dehydrogenase) YP_003070076.1 4508002 D 661410 CDS YP_003070077.1 254562982 8195840 4509060..4509950 1 NC_012988.1 catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases A1518 and A1519 in 16S rRNA; mutations in ksgA causes resistance to the translation initiation inhibitor kasugamycin; dimethyladenosine transferase 4509950 ksgA 8195840 ksgA Methylobacterium extorquens DM4 dimethyladenosine transferase YP_003070077.1 4509060 D 661410 CDS YP_003070078.1 254562983 8194036 complement(4510603..4511649) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4511649 8194036 METDI4633 Methylobacterium extorquens DM4 hypothetical protein YP_003070078.1 4510603 R 661410 CDS YP_003070079.1 254562984 8194039 4513161..4513376 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 4513376 8194039 METDI4636 Methylobacterium extorquens DM4 hypothetical protein YP_003070079.1 4513161 D 661410 CDS YP_003070080.1 254562985 8194040 complement(4513434..4514477) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative hydrolase 4514477 8194040 METDI4637 Methylobacterium extorquens DM4 putative hydrolase YP_003070080.1 4513434 R 661410 CDS YP_003070081.1 254562986 8194041 complement(4514715..4516220) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative sulfate transporter 4516220 8194041 METDI4638 Methylobacterium extorquens DM4 putative sulfate transporter YP_003070081.1 4514715 R 661410 CDS YP_003070082.1 254562987 8194042 complement(4516399..4517115) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; putative Inner membrane protein yohK 4517115 8194042 METDI4639 Methylobacterium extorquens DM4 putative Inner membrane protein yohK YP_003070082.1 4516399 R 661410 CDS YP_003070083.1 254562988 8194043 complement(4517112..4517498) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; putative Holin-like protein cidA 1 4517498 8194043 METDI4640 Methylobacterium extorquens DM4 putative Holin-like protein cidA 1 YP_003070083.1 4517112 R 661410 CDS YP_003070084.1 254562989 8194044 complement(4517625..4518101) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4518101 8194044 METDI4641 Methylobacterium extorquens DM4 hypothetical protein YP_003070084.1 4517625 R 661410 CDS YP_003070085.1 254562990 8194045 complement(4518346..4519080) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4519080 8194045 METDI4642 Methylobacterium extorquens DM4 hypothetical protein YP_003070085.1 4518346 R 661410 CDS YP_003070086.1 254562991 8194046 complement(4519108..4521738) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative organic solvent tolerance protein 4521738 8194046 METDI4643 Methylobacterium extorquens DM4 putative organic solvent tolerance protein YP_003070086.1 4519108 R 661410 CDS YP_003070087.1 254562992 8194047 complement(4521787..4522875) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative permease 4522875 8194047 METDI4644 Methylobacterium extorquens DM4 putative permease YP_003070087.1 4521787 R 661410 CDS YP_003070088.1 254562993 8194048 complement(4522886..4524055) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative permease 4524055 8194048 METDI4645 Methylobacterium extorquens DM4 putative permease YP_003070088.1 4522886 R 661410 CDS YP_003070089.1 254562994 8194049 4524347..4525840 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; cytosol aminopeptidase (putative leucine aminopeptidase) 4525840 8194049 METDI4646 Methylobacterium extorquens DM4 cytosol aminopeptidase (putative leucine aminopeptidase) YP_003070089.1 4524347 D 661410 CDS YP_003070090.1 254562995 8194050 4525837..4526637 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4526637 8194050 METDI4647 Methylobacterium extorquens DM4 hypothetical protein YP_003070090.1 4525837 D 661410 CDS YP_003070091.1 254562996 8194051 4526737..4528473 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 12034706, 8107670; Product type e : enzyme; acyl-CoA synthetase (long-chain-fatty-acid--CoA ligase) 4528473 fadD 8194051 fadD Methylobacterium extorquens DM4 acyl-CoA synthetase (long-chain-fatty-acid--CoA ligase) YP_003070091.1 4526737 D 661410 CDS YP_003070092.1 254562997 8195351 complement(4528478..4528627) 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 4528627 8195351 METDI4649 Methylobacterium extorquens DM4 hypothetical protein YP_003070092.1 4528478 R 661410 CDS YP_003070093.1 254562998 8194052 4528697..4528966 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 4528966 8194052 METDI4650 Methylobacterium extorquens DM4 hypothetical protein YP_003070093.1 4528697 D 661410 CDS YP_003070094.1 254562999 8194053 4528933..4530114 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type m : membrane component; putative MscS mechanosensitive ion channel 4530114 8194053 METDI4651 Methylobacterium extorquens DM4 putative MscS mechanosensitive ion channel YP_003070094.1 4528933 D 661410 CDS YP_003070095.1 254563000 8194054 complement(4530180..4530977) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative thioredoxin domain protein precursor 4530977 8194054 METDI4652 Methylobacterium extorquens DM4 putative thioredoxin domain protein precursor YP_003070095.1 4530180 R 661410 CDS YP_003070096.1 254563001 8194055 4531257..4532300 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative metal-dependent phosphohydrolase (HD domain) 4532300 8194055 METDI4653 Methylobacterium extorquens DM4 putative metal-dependent phosphohydrolase (HD domain) YP_003070096.1 4531257 D 661410 CDS YP_003070097.1 254563002 8194056 4532426..4533739 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 1406271, 2451538, 2456446, 3017428; Product type pt : putative transporter; putative phosphate-selective porin O and P precursor 4533739 8194056 METDI4654 Methylobacterium extorquens DM4 putative phosphate-selective porin O and P precursor YP_003070097.1 4532426 D 661410 CDS YP_003070098.1 254563003 8194057 4533818..4534981 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; aspartate aminotransferase 4534981 8194057 METDI4655 Methylobacterium extorquens DM4 aspartate aminotransferase YP_003070098.1 4533818 D 661410 CDS YP_003070099.1 254563004 8194058 complement(4535015..4535908) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4535908 8194058 METDI4656 Methylobacterium extorquens DM4 hypothetical protein YP_003070099.1 4535015 R 661410 CDS YP_003070100.1 254563005 8194059 4536043..4536330 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 4536330 8194059 METDI4657 Methylobacterium extorquens DM4 hypothetical protein YP_003070100.1 4536043 D 661410 CDS YP_003070101.1 254563006 8194060 complement(4536403..4539564) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10362534, 11328869, 8415644; Product type pe : putative enzyme; putative ribonuclease E or G 4539564 8194060 METDI4658 Methylobacterium extorquens DM4 putative ribonuclease E or G YP_003070101.1 4536403 R 661410 CDS YP_003070102.1 254563007 8194061 4540251..4540436 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4540436 8194061 METDI4659 Methylobacterium extorquens DM4 hypothetical protein YP_003070102.1 4540251 D 661410 CDS YP_003070103.1 254563008 8194062 4540627..4541958 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative N-acetylmuramoyl-L-alanine amidase amiC precursor 4541958 8194062 METDI4660 Methylobacterium extorquens DM4 putative N-acetylmuramoyl-L-alanine amidase amiC precursor YP_003070103.1 4540627 D 661410 CDS YP_003070104.1 254563009 8194063 4542283..4544700 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative bifunctional N-terminal transglycosylase/C-terminal transpeptidase precursor; 1A family penicillin-binding protein 4544700 8194063 METDI4661 Methylobacterium extorquens DM4 putative bifunctional N-terminal transglycosylase/C-terminal transpeptidase precursor; 1A family penicillin-binding protein YP_003070104.1 4542283 D 661410 CDS YP_003070105.1 254563010 8194064 4544992..4546104 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; Alkanesulfonate monooxygenase 4546104 8194064 METDI4662 Methylobacterium extorquens DM4 Alkanesulfonate monooxygenase YP_003070105.1 4544992 D 661410 CDS YP_003070106.1 254563011 8194065 4546289..4547548 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 15661012; Product type pe : putative enzyme; acyl-CoA dehydrogenase 4547548 8194065 METDI4663 Methylobacterium extorquens DM4 acyl-CoA dehydrogenase YP_003070106.1 4546289 D 661410 CDS YP_003070107.1 254563012 8194066 4547686..4548357 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; oxidoreductase, 2Fe-2S subunit 4548357 8194066 METDI4664 Methylobacterium extorquens DM4 oxidoreductase, 2Fe-2S subunit YP_003070107.1 4547686 D 661410 CDS YP_003070108.1 254563013 8194067 4548371..4549345 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; oxidoreductase, FAD-binding subunit 4549345 8194067 METDI4665 Methylobacterium extorquens DM4 oxidoreductase, FAD-binding subunit YP_003070108.1 4548371 D 661410 CDS YP_003070109.1 254563014 8194068 4549357..4551594 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; oxidoreductase, molybdopterin-binding subunit 4551594 8194068 METDI4666 Methylobacterium extorquens DM4 oxidoreductase, molybdopterin-binding subunit YP_003070109.1 4549357 D 661410 CDS YP_003070110.1 254563015 8194069 4551722..4551976 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4551976 8194069 METDI4667 Methylobacterium extorquens DM4 hypothetical protein YP_003070110.1 4551722 D 661410 CDS YP_003070111.1 254563016 8194070 4552086..4553426 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type t : transporter; Xanthine/uracil/vitamin C permease:Sulphate transporter 4553426 yieG 8194070 yieG Methylobacterium extorquens DM4 Xanthine/uracil/vitamin C permease:Sulphate transporter YP_003070111.1 4552086 D 661410 CDS YP_003070112.1 254563017 8196369 4553570..4553764 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4553764 8196369 METDI4669 Methylobacterium extorquens DM4 hypothetical protein YP_003070112.1 4553570 D 661410 CDS YP_003070113.1 254563018 8194071 complement(4553753..4554784) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative monooxygenase with ATPase activity, luciferase family protein 4554784 8194071 METDI4670 Methylobacterium extorquens DM4 putative monooxygenase with ATPase activity, luciferase family protein YP_003070113.1 4553753 R 661410 CDS YP_003070114.1 254563019 8194072 4555367..4555591 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 4555591 8194072 METDI4671 Methylobacterium extorquens DM4 hypothetical protein YP_003070114.1 4555367 D 661410 CDS YP_003070115.1 254563020 8194073 complement(4556059..4556265) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4556265 8194073 METDI4672 Methylobacterium extorquens DM4 hypothetical protein YP_003070115.1 4556059 R 661410 CDS YP_003070116.1 254563021 8194074 complement(4556489..4556998) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative NADPH-dependent FMN reductase, putative ArsH protein 4556998 8194074 METDI4673 Methylobacterium extorquens DM4 putative NADPH-dependent FMN reductase, putative ArsH protein YP_003070116.1 4556489 R 661410 CDS YP_003070117.1 254563022 8194075 complement(4557169..4558350) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4558350 8194075 METDI4674 Methylobacterium extorquens DM4 hypothetical protein YP_003070117.1 4557169 R 661410 CDS YP_003070118.1 254563023 8194076 4558319..4558567 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4558567 8194076 METDI4675 Methylobacterium extorquens DM4 hypothetical protein YP_003070118.1 4558319 D 661410 CDS YP_003070119.1 254563024 8194077 4558752..4560398 1 NC_012988.1 involved in the control of the structural glucose backbone of osmoregulated periplasmic glucans; glucan biosynthesis protein D 4560398 mdoD 8194077 mdoD Methylobacterium extorquens DM4 glucan biosynthesis protein D YP_003070119.1 4558752 D 661410 CDS YP_003070120.1 254563025 8194078 4560450..4562636 1 NC_012988.1 necessary for biosynthesis of osmoregulated periplasmic glucans possibly involved in the transfer to the periplasmic space; glucosyltransferase MdoH 4562636 8194078 METDI4677 Methylobacterium extorquens DM4 glucosyltransferase MdoH YP_003070120.1 4560450 D 661410 CDS YP_003070121.1 254563026 8196260 4563127..4563309 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4563309 8196260 METDI4678 Methylobacterium extorquens DM4 hypothetical protein YP_003070121.1 4563127 D 661410 CDS YP_003070122.1 254563027 8194080 4563553..4563768 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4563768 8194080 METDI4679 Methylobacterium extorquens DM4 hypothetical protein YP_003070122.1 4563553 D 661410 CDS YP_003070123.1 254563028 8194081 complement(4563844..4564635) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4564635 8194081 METDI4680 Methylobacterium extorquens DM4 hypothetical protein YP_003070123.1 4563844 R 661410 CDS YP_003070124.1 254563029 8194082 complement(4564666..4564887) 1 NC_012988.1 Evidence 6 : Doubtful CDS; Product type h : extrachromosomal origin; hypothetical protein 4564887 8194082 METDI4681 Methylobacterium extorquens DM4 hypothetical protein YP_003070124.1 4564666 R 661410 CDS YP_003070125.1 254563030 8194083 4564959..4565126 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 4565126 8194083 METDI4682 Methylobacterium extorquens DM4 hypothetical protein YP_003070125.1 4564959 D 661410 CDS YP_003070126.1 254563031 8194084 complement(4565111..4565326) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4565326 8194084 METDI4683 Methylobacterium extorquens DM4 hypothetical protein YP_003070126.1 4565111 R 661410 CDS YP_003070127.1 254563032 8194085 complement(4565450..4567285) 1 NC_012988.1 catalyzes the hydrolysis of allophanate; allophanate hydrolase 4567285 8194085 METDI4684 Methylobacterium extorquens DM4 allophanate hydrolase YP_003070127.1 4565450 R 661410 CDS YP_003070128.1 254563033 8194086 complement(4567393..4567512) 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 4567512 8194086 METDI4685 Methylobacterium extorquens DM4 hypothetical protein YP_003070128.1 4567393 R 661410 CDS YP_003070129.1 254563034 8194087 complement(4567597..4571127) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 15090492; Product type e : enzyme; ATP-dependent urea carboxylase 4571127 8194087 METDI4686 Methylobacterium extorquens DM4 ATP-dependent urea carboxylase YP_003070129.1 4567597 R 661410 CDS YP_003070130.1 254563035 8194088 complement(4571132..4571752) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4571752 8194088 METDI4687 Methylobacterium extorquens DM4 hypothetical protein YP_003070130.1 4571132 R 661410 CDS YP_003070131.1 254563036 8194089 complement(4571767..4572573) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4572573 8194089 METDI4688 Methylobacterium extorquens DM4 hypothetical protein YP_003070131.1 4571767 R 661410 CDS YP_003070132.1 254563037 8194090 complement(4572736..4573107) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4573107 8194090 METDI4689 Methylobacterium extorquens DM4 hypothetical protein YP_003070132.1 4572736 R 661410 CDS YP_003070133.1 254563038 8194091 complement(4573120..4574493) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 1356885; Product type pe : putative enzyme; putative glutamine synthetase III (glnT) 4574493 8194091 METDI4690 Methylobacterium extorquens DM4 putative glutamine synthetase III (glnT) YP_003070133.1 4573120 R 661410 CDS YP_003070134.1 254563039 8194092 complement(4574495..4575295) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 9563845; Product type e : enzyme; Creatininase 4575295 8194092 METDI4691 Methylobacterium extorquens DM4 Creatininase YP_003070134.1 4574495 R 661410 CDS YP_003070135.1 254563040 8194093 complement(4575292..4576242) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type t : transporter; ABC transporter, ATPase 4576242 8194093 METDI4692 Methylobacterium extorquens DM4 ABC transporter, ATPase YP_003070135.1 4575292 R 661410 CDS YP_003070136.1 254563041 8194094 complement(4576239..4577300) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type t : transporter; ABC transporter, permease 4577300 8194094 METDI4693 Methylobacterium extorquens DM4 ABC transporter, permease YP_003070136.1 4576239 R 661410 CDS YP_003070137.1 254563042 8194095 complement(4577311..4578321) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type t : transporter; ABC transporter, periplasmic protein 4578321 8194095 METDI4694 Methylobacterium extorquens DM4 ABC transporter, periplasmic protein YP_003070137.1 4577311 R 661410 CDS YP_003070138.1 254563043 8195034 4579325..4580653 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type t : transporter; glycine/betaine/proline transporter, ATP-binding component of ABC transporter 4580653 proV 8195034 proV Methylobacterium extorquens DM4 glycine/betaine/proline transporter, ATP-binding component of ABC transporter YP_003070138.1 4579325 D 661410 CDS YP_003070139.1 254563044 8195905 4580569..4581420 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type t : transporter; glycine/betaine/proline transporter, membrane component of ABC transporter 4581420 opuAB 8195905 opuAB Methylobacterium extorquens DM4 glycine/betaine/proline transporter, membrane component of ABC transporter YP_003070139.1 4580569 D 661410 CDS YP_003070140.1 254563045 8195812 4581606..4582442 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type t : transporter; glycine/betaine/proline transporter, Substrate-binding periplasmic component of ABC transporter 4582442 proX 8195812 proX Methylobacterium extorquens DM4 glycine/betaine/proline transporter, Substrate-binding periplasmic component of ABC transporter YP_003070140.1 4581606 D 661410 CDS YP_003070141.1 254563046 8195906 4582523..4583872 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4583872 8195906 METDI4698 Methylobacterium extorquens DM4 hypothetical protein YP_003070141.1 4582523 D 661410 CDS YP_003070142.1 254563047 8194097 complement(4584066..4585010) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type r : regulator; transcriptional regulator, AraC family 4585010 8194097 METDI4699 Methylobacterium extorquens DM4 transcriptional regulator, AraC family YP_003070142.1 4584066 R 661410 CDS YP_003070143.1 254563048 8194098 4585534..4586787 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 7692961, 8611516, 9485355; Product type e : enzyme; sarcosine oxidase, beta subunit 4586787 soxB 8194098 soxB Methylobacterium extorquens DM4 sarcosine oxidase, beta subunit YP_003070143.1 4585534 D 661410 CDS YP_003070144.1 254563049 8196128 4586807..4587103 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 15914915, 7543100; Product type e : enzyme; sarcosine oxidase, delta subunit 4587103 soxD 8196128 soxD Methylobacterium extorquens DM4 sarcosine oxidase, delta subunit YP_003070144.1 4586807 D 661410 CDS YP_003070145.1 254563050 8196131 4587105..4590092 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; sarcosine oxidase, alpha subunit 4590092 soxA 8196131 soxA Methylobacterium extorquens DM4 sarcosine oxidase, alpha subunit YP_003070145.1 4587105 D 661410 CDS YP_003070146.1 254563051 8196125 4590085..4590675 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; sarcosine oxidase, gamma subunit 4590675 soxG 8196125 soxG Methylobacterium extorquens DM4 sarcosine oxidase, gamma subunit YP_003070146.1 4590085 D 661410 CDS YP_003070147.1 254563052 8196133 4590818..4592179 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type e : enzyme; L-serine deaminase 4592179 sdaB 8196133 sdaB Methylobacterium extorquens DM4 L-serine deaminase YP_003070147.1 4590818 D 661410 CDS YP_003070148.1 254563053 8196100 4592576..4592830 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4592830 8196100 METDI4705 Methylobacterium extorquens DM4 hypothetical protein YP_003070148.1 4592576 D 661410 CDS YP_003070149.1 254563054 8194099 complement(4592837..4593346) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4593346 8194099 METDI4706 Methylobacterium extorquens DM4 hypothetical protein YP_003070149.1 4592837 R 661410 CDS YP_003070150.1 254563055 8194100 complement(4593360..4594154) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier; putative electron transfer flavoprotein, beta subunit 4594154 8194100 METDI4707 Methylobacterium extorquens DM4 putative electron transfer flavoprotein, beta subunit YP_003070150.1 4593360 R 661410 CDS YP_003070151.1 254563056 8194101 complement(4594151..4595371) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier; putative electron transfer flavoprotein alpha subunit 4595371 8194101 METDI4708 Methylobacterium extorquens DM4 putative electron transfer flavoprotein alpha subunit YP_003070151.1 4594151 R 661410 CDS YP_003070152.1 254563057 8194102 complement(4595368..4597269) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type c : carrier; Iron-sulfur cluster-binding protein 4597269 8194102 METDI4709 Methylobacterium extorquens DM4 Iron-sulfur cluster-binding protein YP_003070152.1 4595368 R 661410 CDS YP_003070153.1 254563058 8194103 complement(4597557..4599599) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 9758825; Product type e : enzyme; NADH:flavin oxidoreductase/NADH oxidase 4599599 8194103 METDI4710 Methylobacterium extorquens DM4 NADH:flavin oxidoreductase/NADH oxidase YP_003070153.1 4597557 R 661410 CDS YP_003070154.1 254563059 8194104 complement(4599662..4600789) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; Iron-sulfur cluster-binding protein, putative ferredoxin oxidoreductase protein 4600789 8194104 METDI4711 Methylobacterium extorquens DM4 Iron-sulfur cluster-binding protein, putative ferredoxin oxidoreductase protein YP_003070154.1 4599662 R 661410 CDS YP_003070155.1 254563060 8194105 complement(4600793..4602052) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; Iron-sulphur Rieske protein 4602052 8194105 METDI4712 Methylobacterium extorquens DM4 Iron-sulphur Rieske protein YP_003070155.1 4600793 R 661410 CDS YP_003070156.1 254563061 8194106 complement(4602177..4602983) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16901339; Product type pe : putative enzyme; putative L-histidinol-phosphate phosphatase (hisN) 4602983 8194106 METDI4713 Methylobacterium extorquens DM4 putative L-histidinol-phosphate phosphatase (hisN) YP_003070156.1 4602177 R 661410 CDS YP_003070157.1 254563062 8194107 complement(4602987..4603922) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type e : enzyme; putative choline/ethanolamine kinase 4603922 8194107 METDI4714 Methylobacterium extorquens DM4 putative choline/ethanolamine kinase YP_003070157.1 4602987 R 661410 CDS YP_003070158.1 254563063 8194108 complement(4604134..4605114) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4605114 8194108 METDI4715 Methylobacterium extorquens DM4 hypothetical protein YP_003070158.1 4604134 R 661410 CDS YP_003070159.1 254563064 8194109 complement(4605111..4606403) 1 NC_012988.1 allantoate amidohydrolase and N-carbamoyl-L-amino acid amidohydrolase are very similar; the allantoate amidohydrolase from Escherichia coli forms a dimer and binds zinc ions for catalytic activity and catalyzes the conversion of allantoate to (S)-ureidoglycolate and ammonia; carbamoyl amidohydrolase from Bacillus sp. converts N-carbamoyl amino acids to amino acids, ammonia, and carbon dioxide; allantoate amidohydrolase 4606403 8194109 METDI4716 Methylobacterium extorquens DM4 allantoate amidohydrolase YP_003070159.1 4605111 R 661410 CDS YP_003070160.1 254563065 8194110 complement(4606436..4608274) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative ABC transporter, ATP-binding protein; putative peptide transporter 4608274 8194110 METDI4717 Methylobacterium extorquens DM4 putative ABC transporter, ATP-binding protein; putative peptide transporter YP_003070160.1 4606436 R 661410 CDS YP_003070161.1 254563066 8194111 complement(4608274..4609197) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative Oligopeptide/dipeptide ABC transporter, membrane component (ddpC-like) 4609197 8194111 METDI4718 Methylobacterium extorquens DM4 putative Oligopeptide/dipeptide ABC transporter, membrane component (ddpC-like) YP_003070161.1 4608274 R 661410 CDS YP_003070162.1 254563067 8194112 complement(4609197..4610177) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative Oligopeptide/dipeptide ABC transporter, membrane component 4610177 8194112 METDI4719 Methylobacterium extorquens DM4 putative Oligopeptide/dipeptide ABC transporter, membrane component YP_003070162.1 4609197 R 661410 CDS YP_003070163.1 254563068 8194113 complement(4610288..4611859) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative ABC transporter, substrate-binding protein (tat pathway signal) 4611859 8194113 METDI4720 Methylobacterium extorquens DM4 putative ABC transporter, substrate-binding protein (tat pathway signal) YP_003070163.1 4610288 R 661410 CDS YP_003070164.1 254563069 8194114 complement(4612192..4614711) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type prc : putative receptor; tonB-dependent siderophore receptor protein 4614711 8194114 METDI4721 Methylobacterium extorquens DM4 tonB-dependent siderophore receptor protein YP_003070164.1 4612192 R 661410 CDS YP_003070165.1 254563070 8194115 complement(4614882..4615847) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 2254251, 8026465; Product type pr : putative regulator; putative FecR, iron siderophore sensor protein 4615847 8194115 METDI4722 Methylobacterium extorquens DM4 putative FecR, iron siderophore sensor protein YP_003070165.1 4614882 R 661410 CDS YP_003070166.1 254563071 8194116 complement(4615946..4616467) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type f : factor; RNA polymerase sigma factor 4616467 8194116 METDI4723 Methylobacterium extorquens DM4 RNA polymerase sigma factor YP_003070166.1 4615946 R 661410 CDS YP_003070167.1 254563072 8194117 4617348..4619132 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type c : carrier; Siderophore synthetase component 4619132 8194117 METDI4724 Methylobacterium extorquens DM4 Siderophore synthetase component YP_003070167.1 4617348 D 661410 CDS YP_003070168.1 254563073 8194118 4619137..4622097 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative non-ribosomal peptide synthetase, putative acyl-CoA ligase for activation during siderophore synthesis 4622097 8194118 METDI4725 Methylobacterium extorquens DM4 putative non-ribosomal peptide synthetase, putative acyl-CoA ligase for activation during siderophore synthesis YP_003070168.1 4619137 D 661410 CDS YP_003070169.1 254563074 8194119 4622094..4623401 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4623401 8194119 METDI4726 Methylobacterium extorquens DM4 hypothetical protein YP_003070169.1 4622094 D 661410 CDS YP_003070170.1 254563075 8194120 4623398..4624234 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4624234 8194120 METDI4727 Methylobacterium extorquens DM4 hypothetical protein YP_003070170.1 4623398 D 661410 CDS YP_003070171.1 254563076 8194121 4624263..4624541 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4624541 8194121 METDI4728 Methylobacterium extorquens DM4 hypothetical protein YP_003070171.1 4624263 D 661410 CDS YP_003070172.1 254563077 8194122 4624830..4625330 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; GCN5-related N-acetyltransferase 4625330 8194122 METDI4729 Methylobacterium extorquens DM4 GCN5-related N-acetyltransferase YP_003070172.1 4624830 D 661410 CDS YP_003070173.1 254563078 8194123 4625498..4626175 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; PubMedId : 11259647; hypothetical protein 4626175 8194123 METDI4730 Methylobacterium extorquens DM4 hypothetical protein YP_003070173.1 4625498 D 661410 CDS YP_003070174.1 254563079 8194124 complement(4626980..4627753) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcriptional regulator, TetR family 4627753 8194124 METDI4731 Methylobacterium extorquens DM4 putative transcriptional regulator, TetR family YP_003070174.1 4626980 R 661410 CDS YP_003070175.1 254563080 8194125 complement(4627824..4628657) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 2107123, 2199815; Product type e : enzyme; pyrroline-5-carboxylate reductase 4628657 proC 8194125 proC Methylobacterium extorquens DM4 pyrroline-5-carboxylate reductase YP_003070175.1 4627824 R 661410 CDS YP_003070176.1 254563081 8195903 complement(4628739..4629245) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4629245 8195903 METDI4733 Methylobacterium extorquens DM4 hypothetical protein YP_003070176.1 4628739 R 661410 CDS YP_003070177.1 254563082 8194126 complement(4629704..4629985) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4629985 8194126 METDI4734 Methylobacterium extorquens DM4 hypothetical protein YP_003070177.1 4629704 R 661410 CDS YP_003070178.1 254563083 8194127 4630228..4630953 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 10464234, 2845093, 2997120, 3010044, 6292199, 91175693, 92165726, 93287101; Product type r : regulator; response regulator in two-component regulatory system with EnvZ, regulates ompF and ompC expression (OmpR family) 4630953 ompR 8194127 ompR Methylobacterium extorquens DM4 response regulator in two-component regulatory system with EnvZ, regulates ompF and ompC expression (OmpR family) YP_003070178.1 4630228 D 661410 CDS YP_003070179.1 254563084 8195809 4630950..4632428 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative signal transduction histidine kinase precursor 4632428 8195809 METDI4736 Methylobacterium extorquens DM4 putative signal transduction histidine kinase precursor YP_003070179.1 4630950 D 661410 CDS YP_003070180.1 254563085 8194128 4632629..4633801 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative diguanylate cyclase (GGDEF) 4633801 8194128 METDI4737 Methylobacterium extorquens DM4 putative diguanylate cyclase (GGDEF) YP_003070180.1 4632629 D 661410 CDS YP_003070181.1 254563086 8194129 complement(4633930..4634586) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative glutathione S-transferase 4634586 8194129 METDI4738 Methylobacterium extorquens DM4 putative glutathione S-transferase YP_003070181.1 4633930 R 661410 CDS YP_003070182.1 254563087 8194130 4634937..4636151 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 10217786, 11114905, 11267773, 11410342, 12081972, 12813072, 15256572, 8550; Product type e : enzyme; intracellular PHB depolymerase, polyhydroxyalkanoate depolymerase 4636151 8194130 METDI4739 Methylobacterium extorquens DM4 intracellular PHB depolymerase, polyhydroxyalkanoate depolymerase YP_003070182.1 4634937 D 661410 CDS YP_003070183.1 254563088 8194131 4636586..4636903 1 NC_012988.1 a small basic protein that is one of the last in the subunit assembly; omission does not prevent assembly but the subunit is inactive; binds central domain of 16S rRNA; 30S ribosomal protein S21 4636903 rpsU 8194131 rpsU Methylobacterium extorquens DM4 30S ribosomal protein S21 YP_003070183.1 4636586 D 661410 CDS YP_003070184.1 254563089 8196071 complement(4637002..4637391) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative response regulator; (CheY-like protein) 4637391 8196071 METDI4741 Methylobacterium extorquens DM4 putative response regulator; (CheY-like protein) YP_003070184.1 4637002 R 661410 CDS YP_003070185.1 254563090 8194132 4637671..4638456 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative aminohydrolase/amidotransferase 4638456 8194132 METDI4742 Methylobacterium extorquens DM4 putative aminohydrolase/amidotransferase YP_003070185.1 4637671 D 661410 CDS YP_003070186.1 254563091 8194133 4638607..4639398 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 4639398 8194133 METDI4743 Methylobacterium extorquens DM4 hypothetical protein YP_003070186.1 4638607 D 661410 CDS YP_003070187.1 254563092 8194134 complement(4639427..4640473) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 16856937, 17548827, 18065535; Product type e : enzyme; mesaconyl-CoA hydratase 4640473 mcd 8194134 mcd Methylobacterium extorquens DM4 mesaconyl-CoA hydratase YP_003070187.1 4639427 R 661410 CDS YP_003070188.1 254563093 8195665 complement(4640667..4640957) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4640957 8195665 METDI4745 Methylobacterium extorquens DM4 hypothetical protein YP_003070188.1 4640667 R 661410 CDS YP_003070189.1 254563094 8196215 4641261..4642274 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative integrase 4642274 8196215 METDI4746 Methylobacterium extorquens DM4 putative integrase YP_003070189.1 4641261 D 661410 CDS YP_003070190.1 254563095 8194136 complement(4643046..4644587) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative enzyme with a serine protease-like domain 4644587 8194136 METDI4747 Methylobacterium extorquens DM4 putative enzyme with a serine protease-like domain YP_003070190.1 4643046 R 661410 CDS YP_003070191.1 254563096 8194137 4645655..4646959 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4646959 8194137 METDI4749 Methylobacterium extorquens DM4 hypothetical protein YP_003070191.1 4645655 D 661410 CDS YP_003070192.1 254563097 8194138 4647081..4647392 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4647392 8194138 METDI4750 Methylobacterium extorquens DM4 hypothetical protein YP_003070192.1 4647081 D 661410 CDS YP_003070193.1 254563098 8194139 complement(4647865..4648038) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4648038 8194139 METDI4752 Methylobacterium extorquens DM4 hypothetical protein YP_003070193.1 4647865 R 661410 CDS YP_003070194.1 254563099 8194140 4648221..4648643 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type r : regulator; transcriptional regulator (Ros/MucR family) 4648643 8194140 METDI4753 Methylobacterium extorquens DM4 transcriptional regulator (Ros/MucR family) YP_003070194.1 4648221 D 661410 CDS YP_003070195.1 254563100 8194141 complement(4648801..4648998) 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 4648998 8194141 METDI4754 Methylobacterium extorquens DM4 hypothetical protein YP_003070195.1 4648801 R 661410 CDS YP_003070196.1 254563101 8194142 4649178..4649987 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative resolvase, N-terminal 4649987 8194142 METDI4755 Methylobacterium extorquens DM4 putative resolvase, N-terminal YP_003070196.1 4649178 D 661410 CDS YP_003070197.1 254563102 8194143 4650047..4650292 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4650292 8194143 METDI4756 Methylobacterium extorquens DM4 hypothetical protein YP_003070197.1 4650047 D 661410 CDS YP_003070198.1 254563103 8194144 4651415..4652344 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4652344 8194144 METDI4757 Methylobacterium extorquens DM4 hypothetical protein YP_003070198.1 4651415 D 661410 CDS YP_003070199.1 254563104 8194145 4652878..4653117 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4653117 8194145 METDI4758 Methylobacterium extorquens DM4 hypothetical protein YP_003070199.1 4652878 D 661410 CDS YP_003070200.1 254563105 8194146 4653260..4653868 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4653868 8194146 METDI4759 Methylobacterium extorquens DM4 hypothetical protein YP_003070200.1 4653260 D 661410 CDS YP_003070201.1 254563106 8194147 4654119..4654697 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4654697 8194147 METDI4760 Methylobacterium extorquens DM4 hypothetical protein YP_003070201.1 4654119 D 661410 CDS YP_003070202.1 254563107 8194148 complement(4654738..4654989) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4654989 8194148 METDI4761 Methylobacterium extorquens DM4 hypothetical protein YP_003070202.1 4654738 R 661410 CDS YP_003070203.1 254563108 8196216 complement(4656176..4656997) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; Short-chain dehydrogenase/reductase SDR 4656997 8196216 METDI4762 Methylobacterium extorquens DM4 Short-chain dehydrogenase/reductase SDR YP_003070203.1 4656176 R 661410 CDS YP_003070204.1 254563109 8194150 complement(4657190..4657489) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4657489 8194150 METDI4763 Methylobacterium extorquens DM4 hypothetical protein YP_003070204.1 4657190 R 661410 CDS YP_003070205.1 254563110 8194151 4657660..4658166 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type r : regulator; Transcriptional regulator, MarR family 4658166 8194151 METDI4764 Methylobacterium extorquens DM4 Transcriptional regulator, MarR family YP_003070205.1 4657660 D 661410 CDS YP_003070206.1 254563111 8194152 complement(4658229..4658456) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4658456 8194152 METDI4765 Methylobacterium extorquens DM4 hypothetical protein YP_003070206.1 4658229 R 661410 CDS YP_003070207.1 254563112 8194155 complement(4660208..4660750) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type r : regulator; transcriptional regulator, TetR family 4660750 8194155 METDI4769 Methylobacterium extorquens DM4 transcriptional regulator, TetR family YP_003070207.1 4660208 R 661410 CDS YP_003070208.1 254563113 8194156 complement(4660990..4664097) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative AcrB/AcrD/AcrF family protein, putative RND efflux transporter 4664097 8194156 METDI4771 Methylobacterium extorquens DM4 putative AcrB/AcrD/AcrF family protein, putative RND efflux transporter YP_003070208.1 4660990 R 661410 CDS YP_003070209.1 254563114 8194157 complement(4664094..4665146) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type t : transporter; component of multidrug efflux system 4665146 8194157 METDI4772 Methylobacterium extorquens DM4 component of multidrug efflux system YP_003070209.1 4664094 R 661410 CDS YP_003070210.1 254563115 8194158 complement(4665250..4665795) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4665795 8194158 METDI4773 Methylobacterium extorquens DM4 hypothetical protein YP_003070210.1 4665250 R 661410 CDS YP_003070211.1 254563116 8194159 complement(4666233..4667141) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcriptional regulator, LysR family 4667141 8194159 METDI4774 Methylobacterium extorquens DM4 putative transcriptional regulator, LysR family YP_003070211.1 4666233 R 661410 CDS YP_003070212.1 254563117 8194160 4667191..4668117 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative oxidoreductase, aldo/keto reductase family 4668117 8194160 METDI4775 Methylobacterium extorquens DM4 putative oxidoreductase, aldo/keto reductase family YP_003070212.1 4667191 D 661410 CDS YP_003070213.1 254563118 8194161 4668567..4670018 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11872709; Product type pr : putative regulator; putative sensory box/GGDEF family protein 4670018 8194161 METDI4778 Methylobacterium extorquens DM4 putative sensory box/GGDEF family protein YP_003070213.1 4668567 D 661410 CDS YP_003070214.1 254563119 8194162 complement(4670373..4672169) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative phosphodiesterase 4672169 8194162 METDI4779 Methylobacterium extorquens DM4 putative phosphodiesterase YP_003070214.1 4670373 R 661410 CDS YP_003070215.1 254563120 8194163 complement(4672542..4672850) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4672850 8194163 METDI4780 Methylobacterium extorquens DM4 hypothetical protein YP_003070215.1 4672542 R 661410 CDS YP_003070216.1 254563121 8194164 4673118..4674110 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative regulatory protein, LysR family 4674110 8194164 METDI4781 Methylobacterium extorquens DM4 putative regulatory protein, LysR family YP_003070216.1 4673118 D 661410 CDS YP_003070217.1 254563122 8194165 4674642..4675706 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4675706 8194165 METDI4782 Methylobacterium extorquens DM4 hypothetical protein YP_003070217.1 4674642 D 661410 CDS YP_003070218.1 254563123 8194166 4675752..4676855 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4676855 8194166 METDI4783 Methylobacterium extorquens DM4 hypothetical protein YP_003070218.1 4675752 D 661410 CDS YP_003070219.1 254563124 8194167 complement(4676968..4677591) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4677591 8194167 METDI4784 Methylobacterium extorquens DM4 hypothetical protein YP_003070219.1 4676968 R 661410 CDS YP_003070220.1 254563125 8194168 complement(4677800..4678258) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4678258 8194168 METDI4785 Methylobacterium extorquens DM4 hypothetical protein YP_003070220.1 4677800 R 661410 CDS YP_003070221.1 254563126 8194169 complement(4678335..4678595) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4678595 8194169 METDI4786 Methylobacterium extorquens DM4 hypothetical protein YP_003070221.1 4678335 R 661410 CDS YP_003070222.1 254563127 8194170 complement(4678717..4679010) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4679010 8194170 METDI4787 Methylobacterium extorquens DM4 hypothetical protein YP_003070222.1 4678717 R 661410 CDS YP_003070223.1 254563128 8194173 complement(4680047..4680226) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4680226 8194173 METDI4790 Methylobacterium extorquens DM4 hypothetical protein YP_003070223.1 4680047 R 661410 CDS YP_003070224.1 254563129 8194174 complement(4680306..4682261) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4682261 8194174 METDI4791 Methylobacterium extorquens DM4 hypothetical protein YP_003070224.1 4680306 R 661410 CDS YP_003070225.1 254563130 8194175 4682441..4683943 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcriptional regulator, PAS domain S-box 4683943 8194175 METDI4792 Methylobacterium extorquens DM4 putative transcriptional regulator, PAS domain S-box YP_003070225.1 4682441 D 661410 CDS YP_003070226.1 254563131 8194176 4684083..4684265 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4684265 8194176 METDI4793 Methylobacterium extorquens DM4 hypothetical protein YP_003070226.1 4684083 D 661410 CDS YP_003070227.1 254563132 8194177 4684367..4684627 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4684627 8194177 METDI4794 Methylobacterium extorquens DM4 hypothetical protein YP_003070227.1 4684367 D 661410 CDS YP_003070228.1 254563133 8194178 4684676..4685650 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4685650 8194178 METDI4795 Methylobacterium extorquens DM4 hypothetical protein YP_003070228.1 4684676 D 661410 CDS YP_003070229.1 254563134 8194179 4685647..4686162 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4686162 8194179 METDI4796 Methylobacterium extorquens DM4 hypothetical protein YP_003070229.1 4685647 D 661410 CDS YP_003070230.1 254563135 8194180 4686134..4687018 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 15188393, 16926146; hypothetical protein 4687018 8194180 METDI4797 Methylobacterium extorquens DM4 hypothetical protein YP_003070230.1 4686134 D 661410 CDS YP_003070231.1 254563136 8194181 complement(4687537..4687710) 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 4687710 8194181 METDI4798 Methylobacterium extorquens DM4 hypothetical protein YP_003070231.1 4687537 R 661410 CDS YP_003070232.1 254563137 8194182 4687858..4688277 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4688277 8194182 METDI4799 Methylobacterium extorquens DM4 hypothetical protein YP_003070232.1 4687858 D 661410 CDS YP_003070233.1 254563138 8194183 4688352..4689611 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative Poly(3-hydroxybutyrate) depolymerase 4689611 8194183 METDI4800 Methylobacterium extorquens DM4 putative Poly(3-hydroxybutyrate) depolymerase YP_003070233.1 4688352 D 661410 CDS YP_003070234.1 254563139 8194184 complement(4689786..4690721) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative aminohydrolase/amidase precursor 4690721 8194184 METDI4801 Methylobacterium extorquens DM4 putative aminohydrolase/amidase precursor YP_003070234.1 4689786 R 661410 CDS YP_003070235.1 254563140 8194185 4691308..4692234 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative alpha/beta hydrolase 4692234 8194185 METDI4802 Methylobacterium extorquens DM4 putative alpha/beta hydrolase YP_003070235.1 4691308 D 661410 CDS YP_003070236.1 254563141 8194186 complement(4692213..4693082) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative LysR-family transcriptional regulator 4693082 8194186 METDI4803 Methylobacterium extorquens DM4 putative LysR-family transcriptional regulator YP_003070236.1 4692213 R 661410 CDS YP_003070237.1 254563142 8194187 4693179..4693397 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4693397 8194187 METDI4804 Methylobacterium extorquens DM4 hypothetical protein YP_003070237.1 4693179 D 661410 CDS YP_003070238.1 254563143 8194188 4693545..4694252 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4694252 8194188 METDI4805 Methylobacterium extorquens DM4 hypothetical protein YP_003070238.1 4693545 D 661410 CDS YP_003070239.1 254563144 8194189 4694699..4695502 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; PubMedId : 9782511; hypothetical protein 4695502 8194189 METDI4806 Methylobacterium extorquens DM4 hypothetical protein YP_003070239.1 4694699 D 661410 CDS YP_003070240.1 254563145 8194190 4695633..4697330 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type rc : receptor; methyl-accepting chemotaxis receptor/sensory transducer with PAS domain 4697330 8194190 METDI4807 Methylobacterium extorquens DM4 methyl-accepting chemotaxis receptor/sensory transducer with PAS domain YP_003070240.1 4695633 D 661410 CDS YP_003070241.1 254563146 8194191 4697665..4699155 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; Serine protease DO-like 4699155 8194191 METDI4808 Methylobacterium extorquens DM4 Serine protease DO-like YP_003070241.1 4697665 D 661410 CDS YP_003070242.1 254563147 8194192 4699819..4700178 1 NC_012988.1 inactive form; acid-resistance protein 4700178 8194192 METDI4809 Methylobacterium extorquens DM4 acid-resistance protein YP_003070242.1 4699819 D 661410 CDS YP_003070243.1 254563148 8194193 complement(4700513..4700710) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 2497298; hypothetical protein 4700710 8194193 METDI4810 Methylobacterium extorquens DM4 hypothetical protein YP_003070243.1 4700513 R 661410 CDS YP_003070244.1 254563149 8194194 complement(4700768..4702135) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative chloride channel protein 4702135 8194194 METDI4811 Methylobacterium extorquens DM4 putative chloride channel protein YP_003070244.1 4700768 R 661410 CDS YP_003070245.1 254563150 8194195 complement(4702264..4705395) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type t : transporter; transporter, hydrophobe/amphiphile efflux-1 (HAE1) family 4705395 8194195 METDI4812 Methylobacterium extorquens DM4 transporter, hydrophobe/amphiphile efflux-1 (HAE1) family YP_003070245.1 4702264 R 661410 CDS YP_003070246.1 254563151 8194196 complement(4705515..4706825) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative RND efflux transporter, membrane fusion protein subunit 4706825 8194196 METDI4813 Methylobacterium extorquens DM4 putative RND efflux transporter, membrane fusion protein subunit YP_003070246.1 4705515 R 661410 CDS YP_003070247.1 254563152 8194197 complement(4706892..4707125) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4707125 8194197 METDI4814 Methylobacterium extorquens DM4 hypothetical protein YP_003070247.1 4706892 R 661410 CDS YP_003070248.1 254563153 8194198 complement(4707486..4707665) 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 4707665 8194198 METDI4815 Methylobacterium extorquens DM4 hypothetical protein YP_003070248.1 4707486 R 661410 CDS YP_003070249.1 254563154 8194199 complement(4707665..4708675) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 11064196; Product type e : enzyme; cytochrome bd-quinol oxidase subunit II 4708675 qxtB 8194199 qxtB Methylobacterium extorquens DM4 cytochrome bd-quinol oxidase subunit II YP_003070249.1 4707665 R 661410 CDS YP_003070250.1 254563155 8195958 complement(4708690..4710114) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative cytochrome bd-quinol oxidase subunit I (QxtA-like) 4710114 8195958 METDI4817 Methylobacterium extorquens DM4 putative cytochrome bd-quinol oxidase subunit I (QxtA-like) YP_003070250.1 4708690 R 661410 CDS YP_003070251.1 254563156 8194200 complement(4710361..4711143) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4711143 8194200 METDI4819 Methylobacterium extorquens DM4 hypothetical protein YP_003070251.1 4710361 R 661410 CDS YP_003070252.1 254563157 8194201 complement(4711140..4711568) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcriptional regulator, ArsR family 4711568 8194201 METDI4820 Methylobacterium extorquens DM4 putative transcriptional regulator, ArsR family YP_003070252.1 4711140 R 661410 CDS YP_003070253.1 254563158 8194202 complement(4711565..4712464) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; beta-lactamase domain protein 4712464 8194202 METDI4821 Methylobacterium extorquens DM4 beta-lactamase domain protein YP_003070253.1 4711565 R 661410 CDS YP_003070254.1 254563159 8194203 complement(4712461..4713066) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative peroxidase, putative peroxiredoxin 4713066 8194203 METDI4822 Methylobacterium extorquens DM4 putative peroxidase, putative peroxiredoxin YP_003070254.1 4712461 R 661410 CDS YP_003070255.1 254563160 8194204 4713253..4714926 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4714926 8194204 METDI4823 Methylobacterium extorquens DM4 hypothetical protein YP_003070255.1 4713253 D 661410 CDS YP_003070256.1 254563161 8194205 4715175..4716302 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4716302 8194205 METDI4824 Methylobacterium extorquens DM4 hypothetical protein YP_003070256.1 4715175 D 661410 CDS YP_003070257.1 254563162 8194206 complement(4716376..4717242) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative alpha/beta hydrolase, putative epoxide hydrolase 4717242 8194206 METDI4825 Methylobacterium extorquens DM4 putative alpha/beta hydrolase, putative epoxide hydrolase YP_003070257.1 4716376 R 661410 CDS YP_003070258.1 254563163 8194207 4717407..4718456 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12169610; Product type pt : putative transporter; putative ABC transporter, periplasmic protein; putative iron transporter 4718456 8194207 METDI4826 Methylobacterium extorquens DM4 putative ABC transporter, periplasmic protein; putative iron transporter YP_003070258.1 4717407 D 661410 CDS YP_003070259.1 254563164 8194208 4718453..4719502 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type m : membrane component; putative ABC transporter, permease; putative iron transporter 4719502 8194208 METDI4827 Methylobacterium extorquens DM4 putative ABC transporter, permease; putative iron transporter YP_003070259.1 4718453 D 661410 CDS YP_003070260.1 254563165 8194209 4719499..4720272 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative ABC transporter, ATPase; putative iron transporter 4720272 8194209 METDI4828 Methylobacterium extorquens DM4 putative ABC transporter, ATPase; putative iron transporter YP_003070260.1 4719499 D 661410 CDS YP_003070261.1 254563166 8194210 complement(4720282..4721025) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; Sulfite oxidase, oxidoreductase molybdopterin binding 4721025 8194210 METDI4829 Methylobacterium extorquens DM4 Sulfite oxidase, oxidoreductase molybdopterin binding YP_003070261.1 4720282 R 661410 CDS YP_003070262.1 254563167 8194211 complement(4721022..4721750) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4721750 8194211 METDI4830 Methylobacterium extorquens DM4 hypothetical protein YP_003070262.1 4721022 R 661410 CDS YP_003070263.1 254563168 8194212 complement(4721764..4722360) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative S-adenosyl-L-methionine-dependent methyltransferase 4722360 8194212 METDI4831 Methylobacterium extorquens DM4 putative S-adenosyl-L-methionine-dependent methyltransferase YP_003070263.1 4721764 R 661410 CDS YP_003070264.1 254563169 8194213 complement(4722357..4723499) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative acyl-CoA dehydrogenase, putative exported protein 4723499 8194213 METDI4832 Methylobacterium extorquens DM4 putative acyl-CoA dehydrogenase, putative exported protein YP_003070264.1 4722357 R 661410 CDS YP_003070265.1 254563170 8194214 4723774..4724061 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4724061 8194214 METDI4833 Methylobacterium extorquens DM4 hypothetical protein YP_003070265.1 4723774 D 661410 CDS YP_003070266.1 254563171 8194215 4724067..4724312 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4724312 8194215 METDI4834 Methylobacterium extorquens DM4 hypothetical protein YP_003070266.1 4724067 D 661410 CDS YP_003070267.1 254563172 8194216 4724315..4724533 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4724533 8194216 METDI4835 Methylobacterium extorquens DM4 hypothetical protein YP_003070267.1 4724315 D 661410 CDS YP_003070268.1 254563173 8194217 complement(4724621..4725655) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative oxidoreductase, aldo/keto reductase family 4725655 8194217 METDI4836 Methylobacterium extorquens DM4 putative oxidoreductase, aldo/keto reductase family YP_003070268.1 4724621 R 661410 CDS YP_003070269.1 254563174 8194218 4725971..4726198 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4726198 8194218 METDI4837 Methylobacterium extorquens DM4 hypothetical protein YP_003070269.1 4725971 D 661410 CDS YP_003070270.1 254563175 8194219 complement(4726204..4726803) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative Isochorismatase hydrolase 4726803 8194219 METDI4838 Methylobacterium extorquens DM4 putative Isochorismatase hydrolase YP_003070270.1 4726204 R 661410 CDS YP_003070271.1 254563176 8194220 complement(4727077..4728351) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 9140968; Product type t : transporter; Efflux transporter, RND family, membrane fusion protein subunit 4728351 ragD 8194220 ragD Methylobacterium extorquens DM4 Efflux transporter, RND family, membrane fusion protein subunit YP_003070271.1 4727077 R 661410 CDS YP_003070272.1 254563177 8195963 complement(4728386..4731616) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 10675036; Product type t : transporter; multidrug efflux pump 4731616 ragC 8195963 ragC Methylobacterium extorquens DM4 multidrug efflux pump YP_003070272.1 4728386 R 661410 CDS YP_003070273.1 254563178 8195962 complement(4731930..4733306) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4733306 8195962 METDI4841 Methylobacterium extorquens DM4 hypothetical protein YP_003070273.1 4731930 R 661410 CDS YP_003070274.1 254563179 8194221 complement(4733303..4733998) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4733998 8194221 METDI4842 Methylobacterium extorquens DM4 hypothetical protein YP_003070274.1 4733303 R 661410 CDS YP_003070275.1 254563180 8194222 complement(4734030..4734959) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative oxidoreductase precursor, putative aldo/keto reductase precursor (tat pathway signal) 4734959 8194222 METDI4843 Methylobacterium extorquens DM4 putative oxidoreductase precursor, putative aldo/keto reductase precursor (tat pathway signal) YP_003070275.1 4734030 R 661410 CDS YP_003070276.1 254563181 8194223 complement(4735032..4735586) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative methyltransferase with SAM-dependent methyltransferase domain 4735586 yhhF 8194223 yhhF Methylobacterium extorquens DM4 putative methyltransferase with SAM-dependent methyltransferase domain YP_003070276.1 4735032 R 661410 CDS YP_003070277.1 254563182 8196368 complement(4735599..4737608) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4737608 8196368 METDI4845 Methylobacterium extorquens DM4 hypothetical protein YP_003070277.1 4735599 R 661410 CDS YP_003070278.1 254563183 8194224 complement(4737699..4737875) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4737875 8194224 METDI4846 Methylobacterium extorquens DM4 hypothetical protein YP_003070278.1 4737699 R 661410 CDS YP_003070279.1 254563184 8194225 complement(4738043..4738810) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 10788346; Product type e : enzyme; NADPH-dependent FMN reductase 4738810 arsH 8194225 arsH Methylobacterium extorquens DM4 NADPH-dependent FMN reductase YP_003070279.1 4738043 R 661410 CDS YP_003070280.1 254563185 8195103 4738861..4739220 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 10788346, 12829264, 9537360; Product type r : regulator; transcriptional regulator, ArsR family 4739220 arsR 8195103 arsR Methylobacterium extorquens DM4 transcriptional regulator, ArsR family YP_003070280.1 4738861 D 661410 CDS YP_003070281.1 254563186 8195106 4739213..4739650 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 16905151, 17432936; Product type e : enzyme; arsenate reductase (glutaredoxin family) 4739650 arsC 8195106 arsC Methylobacterium extorquens DM4 arsenate reductase (glutaredoxin family) YP_003070281.1 4739213 D 661410 CDS YP_003070282.1 254563187 8195100 4739660..4740736 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative arsenite efflux pump ACR3 precursor 4740736 8195100 METDI4850 Methylobacterium extorquens DM4 putative arsenite efflux pump ACR3 precursor YP_003070282.1 4739660 D 661410 CDS YP_003070283.1 254563188 8194226 complement(4740937..4743039) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type prc : putative receptor; putative diguanylate cyclase (GGDEF) /phosphodiesterase (EAL) with PAS/PAC sensor 4743039 8194226 METDI4851 Methylobacterium extorquens DM4 putative diguanylate cyclase (GGDEF) /phosphodiesterase (EAL) with PAS/PAC sensor YP_003070283.1 4740937 R 661410 CDS YP_003070284.1 254563189 8194227 4743343..4744260 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 1512562; Product type pe : putative enzyme; putative alpha/beta hydrolase, putative haloacetate dehalogenase 4744260 8194227 METDI4852 Methylobacterium extorquens DM4 putative alpha/beta hydrolase, putative haloacetate dehalogenase YP_003070284.1 4743343 D 661410 CDS YP_003070285.1 254563190 8194228 complement(4744265..4744966) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative short-chain dehydrogenase/reductase SDR 4744966 8194228 METDI4853 Methylobacterium extorquens DM4 putative short-chain dehydrogenase/reductase SDR YP_003070285.1 4744265 R 661410 CDS YP_003070286.1 254563191 8194229 complement(4745058..4745501) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 12110595; Product type e : enzyme; tRNA-specific adenosine deaminase 4745501 tadA 8194229 tadA Methylobacterium extorquens DM4 tRNA-specific adenosine deaminase YP_003070286.1 4745058 R 661410 CDS YP_003070287.1 254563192 8196177 complement(4745515..4746822) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 2687276, 9843369; Product type e : enzyme; phosphoribosylglycinamide synthetase (GAR synthetase) 4746822 purD 8196177 purD Methylobacterium extorquens DM4 phosphoribosylglycinamide synthetase (GAR synthetase) YP_003070287.1 4745515 R 661410 CDS YP_003070288.1 254563193 8195932 4746906..4747643 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4747643 8195932 METDI4856 Methylobacterium extorquens DM4 hypothetical protein YP_003070288.1 4746906 D 661410 CDS YP_003070289.1 254563194 8194230 4747730..4747945 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 4747945 8194230 METDI4857 Methylobacterium extorquens DM4 hypothetical protein YP_003070289.1 4747730 D 661410 CDS YP_003070290.1 254563195 8194231 4748169..4749737 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 3021756, 6284744; Product type pe : putative enzyme; putative exonuclease VII, large subunit OB-fold nucleic acid binding domain 4749737 xseA 8194231 xseA Methylobacterium extorquens DM4 putative exonuclease VII, large subunit OB-fold nucleic acid binding domain YP_003070290.1 4748169 D 661410 CDS YP_003070291.1 254563196 8196343 complement(4749794..4750171) 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 4750171 8196343 METDI4859 Methylobacterium extorquens DM4 hypothetical protein YP_003070291.1 4749794 R 661410 CDS YP_003070292.1 254563197 8194232 4750386..4750613 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4750613 8194232 METDI4860 Methylobacterium extorquens DM4 hypothetical protein YP_003070292.1 4750386 D 661410 CDS YP_003070293.1 254563198 8194233 4750781..4751725 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 3009477; Product type e : enzyme; phosphoribosylpyrophosphate synthetase 4751725 prs 8194233 prs Methylobacterium extorquens DM4 phosphoribosylpyrophosphate synthetase YP_003070293.1 4750781 D 661410 CDS YP_003070294.1 254563199 8195907 complement(4751847..4752311) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8431948; Product type pe : putative enzyme; putative GreA/GreB family transcription elongation factor 4752311 8195907 METDI4862 Methylobacterium extorquens DM4 putative GreA/GreB family transcription elongation factor YP_003070294.1 4751847 R 661410 CDS YP_003070295.1 254563200 8194234 complement(4752332..4753330) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15388933, 8020473, 8049268; Product type pe : putative enzyme; putative Zn-dependent oxidoreductase, NAD(P)-binding and GroES-like domains 4753330 8194234 METDI4863 Methylobacterium extorquens DM4 putative Zn-dependent oxidoreductase, NAD(P)-binding and GroES-like domains YP_003070295.1 4752332 R 661410 CDS YP_003070296.1 254563201 8194235 complement(4753436..4754035) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4754035 8194235 METDI4864 Methylobacterium extorquens DM4 hypothetical protein YP_003070296.1 4753436 R 661410 CDS YP_003070297.1 254563202 8194236 4754514..4754852 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 2388848; Product type e : enzyme; ferredoxin II 4754852 fdxA 8194236 fdxA Methylobacterium extorquens DM4 ferredoxin II YP_003070297.1 4754514 D 661410 CDS YP_003070298.1 254563203 8195371 4755288..4755962 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 11535780; Product type r : regulator; transcriptional regulator, CarD family 4755962 8195371 METDI4866 Methylobacterium extorquens DM4 transcriptional regulator, CarD family YP_003070298.1 4755288 D 661410 CDS YP_003070299.1 254563204 8194237 4756245..4757117 1 NC_012988.1 binds with the catalytic core of RNA polymerase to produce the holoenzyme; sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; sigma-32 is responsible for the expression of heat shock promoters; there are paralogs in Rhizobium and Sinorhizobium; the proteins in this cluster act as secondary heat shock sigma factors; the Rhizobium sigma-32 factor may also be involved in exopolysaccharide production; RNA polymerase factor sigma-32 4757117 rpoH2 8194237 rpoH2 Methylobacterium extorquens DM4 RNA polymerase factor sigma-32 YP_003070299.1 4756245 D 661410 CDS YP_003070300.1 254563205 8194240 complement(4759456..4760928) 1 NC_012988.1 TrmFO; Gid; glucose-inhibited division protein; similar to GidA; the gene from Bacillus subtilis encodes a tRNA-methyltransferase that utilizes folate as the carbon donor and bound flavin as reductant; modifies tRNA at position 54 (uridine) of the T-psi loop to form a C5-methyluridine; tRNA (uracil-5-)-methyltransferase Gid 4760928 gid 8194240 gid Methylobacterium extorquens DM4 tRNA (uracil-5-)-methyltransferase Gid YP_003070300.1 4759456 R 661410 CDS YP_003070301.1 254563206 8195483 4761174..4762796 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4762796 8195483 METDI4872 Methylobacterium extorquens DM4 hypothetical protein YP_003070301.1 4761174 D 661410 CDS YP_003070302.1 254563207 8194241 complement(4762835..4763809) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative serine protease, htrA-like 4763809 8194241 METDI4873 Methylobacterium extorquens DM4 putative serine protease, htrA-like YP_003070302.1 4762835 R 661410 CDS YP_003070303.1 254563208 8194242 4764250..4764804 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type f : factor; RNA polymerase sigma factor 4764804 8194242 METDI4874 Methylobacterium extorquens DM4 RNA polymerase sigma factor YP_003070303.1 4764250 D 661410 CDS YP_003070304.1 254563209 8194243 4764801..4765580 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4765580 8194243 METDI4875 Methylobacterium extorquens DM4 hypothetical protein YP_003070304.1 4764801 D 661410 CDS YP_003070305.1 254563210 8194244 complement(4765745..4766683) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10433972; Product type pf : putative factor; putative CoxB-related 4766683 8194244 METDI4876 Methylobacterium extorquens DM4 putative CoxB-related YP_003070305.1 4765745 R 661410 CDS YP_003070306.1 254563211 8194245 complement(4767239..4770304) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 1826851; Product type e : enzyme; DNA excision repair enzyme subunit, with UvrBC 4770304 uvrA 8194245 uvrA Methylobacterium extorquens DM4 DNA excision repair enzyme subunit, with UvrBC YP_003070306.1 4767239 R 661410 CDS YP_003070307.1 254563212 8196329 4770725..4771783 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4771783 8196329 METDI4878 Methylobacterium extorquens DM4 hypothetical protein YP_003070307.1 4770725 D 661410 CDS YP_003070308.1 254563213 8194246 4771946..4773985 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4773985 8194246 METDI4879 Methylobacterium extorquens DM4 hypothetical protein YP_003070308.1 4771946 D 661410 CDS YP_003070309.1 254563214 8194247 complement(4774104..4775309) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative RND efflux transporter, membrane fusion protein subunit 4775309 8194247 METDI4880 Methylobacterium extorquens DM4 putative RND efflux transporter, membrane fusion protein subunit YP_003070309.1 4774104 R 661410 CDS YP_003070310.1 254563215 8194248 4775464..4778628 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative Multidrug resistance protein mexB (Multidrug-efflux transporter mexB) 4778628 8194248 METDI4881 Methylobacterium extorquens DM4 putative Multidrug resistance protein mexB (Multidrug-efflux transporter mexB) YP_003070310.1 4775464 D 661410 CDS YP_003070311.1 254563216 8194249 complement(4778639..4779040) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative Response regulator receiver 4779040 8194249 METDI4882 Methylobacterium extorquens DM4 putative Response regulator receiver YP_003070311.1 4778639 R 661410 CDS YP_003070312.1 254563217 8194250 complement(4779145..4781925) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative histidine kinase of the HWE family 4781925 8194250 METDI4883 Methylobacterium extorquens DM4 putative histidine kinase of the HWE family YP_003070312.1 4779145 R 661410 CDS YP_003070313.1 254563218 8194251 complement(4782151..4782912) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcriptional regulator, Crp/Fnr family 4782912 8194251 METDI4885 Methylobacterium extorquens DM4 putative transcriptional regulator, Crp/Fnr family YP_003070313.1 4782151 R 661410 CDS YP_003070314.1 254563219 8194252 complement(4783167..4784018) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; Glycoside hydrolase, family 25 4784018 8194252 METDI4886 Methylobacterium extorquens DM4 Glycoside hydrolase, family 25 YP_003070314.1 4783167 R 661410 CDS YP_003070315.1 254563220 8194253 4784216..4784668 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4784668 8194253 METDI4887 Methylobacterium extorquens DM4 hypothetical protein YP_003070315.1 4784216 D 661410 CDS YP_003070316.1 254563221 8194254 complement(4784723..4785958) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 10858449; Product type e : enzyme; 2-octaprenyl-6-methoxyphenol hydroxylase (FAD-dependent oxidoreductase) 4785958 ubiH 8194254 ubiH Methylobacterium extorquens DM4 2-octaprenyl-6-methoxyphenol hydroxylase (FAD-dependent oxidoreductase) YP_003070316.1 4784723 R 661410 CDS YP_003070317.1 254563222 8196296 4786371..4786574 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 4786574 8196296 METDI4889 Methylobacterium extorquens DM4 hypothetical protein YP_003070317.1 4786371 D 661410 CDS YP_003070318.1 254563223 8194255 4786571..4786798 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4786798 8194255 METDI4890 Methylobacterium extorquens DM4 hypothetical protein YP_003070318.1 4786571 D 661410 CDS YP_003070319.1 254563224 8194256 4786987..4787958 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 7602590, 94089392; Product type e : enzyme; quinone oxidoreductase, NADPH-dependent 4787958 qor 8194256 qor Methylobacterium extorquens DM4 quinone oxidoreductase, NADPH-dependent YP_003070319.1 4786987 D 661410 CDS YP_003070320.1 254563225 8195954 4788143..4788769 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 2670682, 72060410, 8726014; Product type e : enzyme; nicotinamidase 4788769 pncA 8195954 pncA Methylobacterium extorquens DM4 nicotinamidase YP_003070320.1 4788143 D 661410 CDS YP_003070321.1 254563226 8195869 complement(4788939..4789796) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12670965; Product type pe : putative enzyme; putative branched-chain amino acid aminotransferase 4789796 8195869 METDI4893 Methylobacterium extorquens DM4 putative branched-chain amino acid aminotransferase YP_003070321.1 4788939 R 661410 CDS YP_003070322.1 254563227 8194257 complement(4789783..4790412) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 2071583, 7592344, 8096767; Product type e : enzyme; aminodeoxychorismate synthase subunit II, component of p-aminobenzoate synthase multienzyme complex 4790412 pabA 8194257 pabA Methylobacterium extorquens DM4 aminodeoxychorismate synthase subunit II, component of p-aminobenzoate synthase multienzyme complex YP_003070322.1 4789783 R 661410 CDS YP_003070323.1 254563228 8195822 complement(4790409..4791809) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 2251281, 3057324; Product type e : enzyme; putative para-aminobenzoate synthase component 4791809 8195822 METDI4895 Methylobacterium extorquens DM4 putative para-aminobenzoate synthase component YP_003070323.1 4790409 R 661410 CDS YP_003070324.1 254563229 8194258 4792102..4792365 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type f : factor; RelB/dinJ family addiction module antitoxin 4792365 dinJ 8194258 dinJ Methylobacterium extorquens DM4 RelB/dinJ family addiction module antitoxin YP_003070324.1 4792102 D 661410 CDS YP_003070325.1 254563230 8195296 4792403..4792633 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type f : factor; RelE/StbE family addiction module toxin 4792633 8195296 METDI4897 Methylobacterium extorquens DM4 RelE/StbE family addiction module toxin YP_003070325.1 4792403 D 661410 CDS YP_003070326.1 254563231 8194259 4792750..4794096 1 NC_012988.1 catalyzes the methylthiolation of an aspartic acid residue of the S12 protein of the 30S ribosomal subunit; ribosomal protein S12 methylthiotransferase 4794096 rimO 8194259 rimO Methylobacterium extorquens DM4 ribosomal protein S12 methylthiotransferase YP_003070326.1 4792750 D 661410 CDS YP_003070327.1 254563232 8196372 4794193..4794378 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 4794378 8196372 METDI4899 Methylobacterium extorquens DM4 hypothetical protein YP_003070327.1 4794193 D 661410 CDS YP_003070328.1 254563233 8194260 4794385..4794807 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4794807 8194260 METDI4900 Methylobacterium extorquens DM4 hypothetical protein YP_003070328.1 4794385 D 661410 CDS YP_003070329.1 254563234 8194261 4794896..4795087 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 4795087 8194261 METDI4901 Methylobacterium extorquens DM4 hypothetical protein YP_003070329.1 4794896 D 661410 CDS YP_003070330.1 254563235 8194262 complement(4795172..4796002) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 12218018; Product type e : enzyme; nucleoside triphosphate pyrophosphohydrolase MazG 4796002 mazG 8194262 mazG Methylobacterium extorquens DM4 nucleoside triphosphate pyrophosphohydrolase MazG YP_003070330.1 4795172 R 661410 CDS YP_003070331.1 254563236 8195664 4796757..4797854 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; Plasmid replication protein RepA 4797854 8195664 METDI4903 Methylobacterium extorquens DM4 Plasmid replication protein RepA YP_003070331.1 4796757 D 661410 CDS YP_003070332.1 254563237 8194263 4798332..4798886 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4798886 8194263 METDI4904 Methylobacterium extorquens DM4 hypothetical protein YP_003070332.1 4798332 D 661410 CDS YP_003070333.1 254563238 8194264 complement(4799017..4800324) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative patatin-like phospholipase 4800324 8194264 METDI4905 Methylobacterium extorquens DM4 putative patatin-like phospholipase YP_003070333.1 4799017 R 661410 CDS YP_003070334.1 254563239 8194265 4800843..4801892 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16926146; Product type pe : putative enzyme; putative carbon-carbon lyase, HpcH/HpaI aldolase/citrate lyase family 4801892 8194265 METDI4906 Methylobacterium extorquens DM4 putative carbon-carbon lyase, HpcH/HpaI aldolase/citrate lyase family YP_003070334.1 4800843 D 661410 CDS YP_003070335.1 254563240 8194266 4801916..4802290 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12700277; Product type f : factor; putative DNA-binding protein, hemimethylated (yccV-like) 4802290 8194266 METDI4907 Methylobacterium extorquens DM4 putative DNA-binding protein, hemimethylated (yccV-like) YP_003070335.1 4801916 D 661410 CDS YP_003070336.1 254563241 8194267 4802471..4803697 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative diguanylate cyclase precursor (GGDEF motif); putative membrane protein 4803697 8194267 METDI4908 Methylobacterium extorquens DM4 putative diguanylate cyclase precursor (GGDEF motif); putative membrane protein YP_003070336.1 4802471 D 661410 CDS YP_003070337.1 254563242 8194268 complement(4803849..4804031) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4804031 8194268 METDI4909 Methylobacterium extorquens DM4 hypothetical protein YP_003070337.1 4803849 R 661410 CDS YP_003070338.1 254563243 8194269 4804314..4805522 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative efflux transporter, membrane fusion protein subunit precursor; putative HlyD family secretion protein precursor 4805522 8194269 METDI4910 Methylobacterium extorquens DM4 putative efflux transporter, membrane fusion protein subunit precursor; putative HlyD family secretion protein precursor YP_003070338.1 4804314 D 661410 CDS YP_003070339.1 254563244 8194270 4805533..4808673 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type t : transporter; efflux transporter, AcrB/AcrD/AcrF family protein 4808673 8194270 METDI4911 Methylobacterium extorquens DM4 efflux transporter, AcrB/AcrD/AcrF family protein YP_003070339.1 4805533 D 661410 CDS YP_003070340.1 254563245 8194271 complement(4808703..4808969) 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 4808969 8194271 METDI4912 Methylobacterium extorquens DM4 hypothetical protein YP_003070340.1 4808703 R 661410 CDS YP_003070341.1 254563246 8194272 4809089..4810246 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative metal-dependent phosphohydrolase (HD domain) 4810246 8194272 METDI4913 Methylobacterium extorquens DM4 putative metal-dependent phosphohydrolase (HD domain) YP_003070341.1 4809089 D 661410 CDS YP_003070342.1 254563247 8194273 complement(4810300..4811337) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; agmatinase (ureohydrolase) 4811337 8194273 METDI4914 Methylobacterium extorquens DM4 agmatinase (ureohydrolase) YP_003070342.1 4810300 R 661410 CDS YP_003070343.1 254563248 8194274 4811690..4812694 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4812694 8194274 METDI4915 Methylobacterium extorquens DM4 hypothetical protein YP_003070343.1 4811690 D 661410 CDS YP_003070344.1 254563249 8194275 complement(4812866..4813180) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4813180 8194275 METDI4916 Methylobacterium extorquens DM4 hypothetical protein YP_003070344.1 4812866 R 661410 CDS YP_003070345.1 254563250 8194276 complement(4813380..4814669) 1 NC_012988.1 (DNA/pantothenate metabolism flavoprotein) [Phosphopantothenoylcysteine decarboxylase (PPCDC) (CoaC); Phosphopantothenate-cysteine ligase (Phosphopantothenoylcysteine synthase) (PPC synthetase) (PPCS) (CoaB)]; Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; Coenzyme A biosynthesis bifunctional protein coaBC 4814669 coaBC 8194276 coaBC Methylobacterium extorquens DM4 Coenzyme A biosynthesis bifunctional protein coaBC YP_003070345.1 4813380 R 661410 CDS YP_003070346.1 254563251 8195178 4814910..4816010 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative restriction endonuclease or methylase 4816010 8195178 METDI4918 Methylobacterium extorquens DM4 putative restriction endonuclease or methylase YP_003070346.1 4814910 D 661410 CDS YP_003070347.1 254563252 8194277 complement(4816021..4816248) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4816248 8194277 METDI4919 Methylobacterium extorquens DM4 hypothetical protein YP_003070347.1 4816021 R 661410 CDS YP_003070348.1 254563253 8194278 complement(4816291..4817856) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 10960098, 11583838; Product type e : enzyme; ubiquinone biosynthesis protein, putative 2-polyprenylphenol 6-hydroxylase 4817856 ubiB 8194278 ubiB Methylobacterium extorquens DM4 ubiquinone biosynthesis protein, putative 2-polyprenylphenol 6-hydroxylase YP_003070348.1 4816291 R 661410 CDS YP_003070349.1 254563254 8196294 complement(4818080..4818859) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 10960098, 1444716, 195601, 365223, 4323297, 9045837; Product type e : enzyme; Ubiquinone/menaquinone biosynthesis methyltransferase ubiE 4818859 ubiE 8196294 ubiE Methylobacterium extorquens DM4 Ubiquinone/menaquinone biosynthesis methyltransferase ubiE YP_003070349.1 4818080 R 661410 CDS YP_003070350.1 254563255 8196295 complement(4818990..4819397) 1 NC_012988.1 Evidence 1c : Function experimentally demonstrated in the studied genus; Product type e : enzyme; Dihydromethanopterin reductase 4819397 dmrA 8196295 dmrA Methylobacterium extorquens DM4 Dihydromethanopterin reductase YP_003070350.1 4818990 R 661410 CDS YP_003070351.1 254563256 8195300 complement(4819470..4820213) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; Short-chain dehydrogenase/reductase SDR 4820213 8195300 METDI4923 Methylobacterium extorquens DM4 Short-chain dehydrogenase/reductase SDR YP_003070351.1 4819470 R 661410 CDS YP_003070352.1 254563257 8194279 complement(4820219..4821694) 1 NC_012988.1 Catalyzes first step of the de novo purine nucleotide biosynthetic pathway; amidophosphoribosyltransferase 4821694 purF 8194279 purF Methylobacterium extorquens DM4 amidophosphoribosyltransferase YP_003070352.1 4820219 R 661410 CDS YP_003070353.1 254563258 8195934 complement(4822093..4822686) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 2542219, 2991286; Product type m : membrane component; Colicin V-related production protein (membrane protein dedE-related) (putative Pur regulon protein) 4822686 8195934 METDI4925 Methylobacterium extorquens DM4 Colicin V-related production protein (membrane protein dedE-related) (putative Pur regulon protein) YP_003070353.1 4822093 R 661410 CDS YP_003070354.1 254563259 8194280 4823074..4824192 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative metallo-hydrolase/oxidoreductase precursor, putative exonuclease precursor (tat pathway signal) 4824192 8194280 METDI4926 Methylobacterium extorquens DM4 putative metallo-hydrolase/oxidoreductase precursor, putative exonuclease precursor (tat pathway signal) YP_003070354.1 4823074 D 661410 CDS YP_003070355.1 254563260 8194281 4824185..4824802 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4824802 8194281 METDI4927 Methylobacterium extorquens DM4 hypothetical protein YP_003070355.1 4824185 D 661410 CDS YP_003070356.1 254563261 8194282 complement(4824830..4826260) 1 NC_012988.1 Sms; stabilizes the strand-invasion intermediate during the DNA repair; involved in recombination of donor DNA and plays an important role in DNA damage repair after exposure to mutagenic agents; DNA repair protein RadA 4826260 radA 8194282 radA Methylobacterium extorquens DM4 DNA repair protein RadA YP_003070356.1 4824830 R 661410 CDS YP_003070357.1 254563262 8195959 complement(4826440..4827468) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative alanine racemase (alr-like) 4827468 8195959 METDI4929 Methylobacterium extorquens DM4 putative alanine racemase (alr-like) YP_003070357.1 4826440 R 661410 CDS YP_003070358.1 254563263 8194283 complement(4827626..4829113) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; replicative DNA helicase (dnaB) 4829113 dnaB 8194283 dnaB Methylobacterium extorquens DM4 replicative DNA helicase (dnaB) YP_003070358.1 4827626 R 661410 CDS YP_003070359.1 254563264 8195303 complement(4829434..4830006) 1 NC_012988.1 in Escherichia coli this protein is wrapped around the base of the L1 stalk; 50S ribosomal protein L9 4830006 rplI 8195303 rplI Methylobacterium extorquens DM4 50S ribosomal protein L9 YP_003070359.1 4829434 R 661410 CDS YP_003070360.1 254563265 8196020 complement(4830044..4831102) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4831102 8196020 METDI4932 Methylobacterium extorquens DM4 hypothetical protein YP_003070360.1 4830044 R 661410 CDS YP_003070361.1 254563266 8194284 complement(4831238..4831492) 1 NC_012988.1 binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit; 30S ribosomal protein S18 4831492 rpsR 8194284 rpsR Methylobacterium extorquens DM4 30S ribosomal protein S18 YP_003070361.1 4831238 R 661410 CDS YP_003070362.1 254563267 8196069 complement(4831495..4831950) 1 NC_012988.1 binds cooperatively with S18 to the S15-16S complex, allowing platform assembly to continue with S11 and S21; 30S ribosomal protein S6 4831950 rpsF 8196069 rpsF Methylobacterium extorquens DM4 30S ribosomal protein S6 YP_003070362.1 4831495 R 661410 CDS YP_003070363.1 254563268 8196057 complement(4832151..4832699) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 2549372; Product type e : enzyme; Gentamicin 3'-N-acetyltransferase 4832699 8196057 METDI4935 Methylobacterium extorquens DM4 Gentamicin 3'-N-acetyltransferase YP_003070363.1 4832151 R 661410 CDS YP_003070364.1 254563269 8194285 complement(4832709..4833083) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4833083 8194285 METDI4936 Methylobacterium extorquens DM4 hypothetical protein YP_003070364.1 4832709 R 661410 CDS YP_003070365.1 254563270 8194286 complement(4833155..4833484) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; PubMedId : 12957906; hypothetical protein 4833484 8194286 METDI4937 Methylobacterium extorquens DM4 hypothetical protein YP_003070365.1 4833155 R 661410 CDS YP_003070366.1 254563271 8194287 complement(4833894..4834274) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4834274 8194287 METDI4938 Methylobacterium extorquens DM4 hypothetical protein YP_003070366.1 4833894 R 661410 CDS YP_003070367.1 254563272 8194288 complement(4834520..4834729) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 10515936, 10618253, 10696873; Product type f : factor; cold shock protein A 4834729 cspA 8194288 cspA Methylobacterium extorquens DM4 cold shock protein A YP_003070367.1 4834520 R 661410 CDS YP_003070368.1 254563273 8195224 complement(4835322..4835582) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4835582 8195224 METDI4940 Methylobacterium extorquens DM4 hypothetical protein YP_003070368.1 4835322 R 661410 CDS YP_003070369.1 254563274 8194289 4836034..4836564 1 NC_012988.1 cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+); peptide deformylase 4836564 def 8194289 def Methylobacterium extorquens DM4 peptide deformylase YP_003070369.1 4836034 D 661410 CDS YP_003070370.1 254563275 8195285 4836690..4837133 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4837133 8195285 METDI4942 Methylobacterium extorquens DM4 hypothetical protein YP_003070370.1 4836690 D 661410 CDS YP_003070371.1 254563276 8194290 complement(4837155..4839326) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type t : transporter; TonB-dependent receptor/siderophore receptor protein 4839326 8194290 METDI4943 Methylobacterium extorquens DM4 TonB-dependent receptor/siderophore receptor protein YP_003070371.1 4837155 R 661410 CDS YP_003070372.1 254563277 8194291 4839615..4840460 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4840460 8194291 METDI4944 Methylobacterium extorquens DM4 hypothetical protein YP_003070372.1 4839615 D 661410 CDS YP_003070373.1 254563278 8194292 complement(4840477..4840986) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4840986 8194292 METDI4945 Methylobacterium extorquens DM4 hypothetical protein YP_003070373.1 4840477 R 661410 CDS YP_003070374.1 254563279 8194293 4841324..4841815 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; GCN5-related N-acetyltransferase 4841815 8194293 METDI4946 Methylobacterium extorquens DM4 GCN5-related N-acetyltransferase YP_003070374.1 4841324 D 661410 CDS YP_003070375.1 254563280 8194294 4841896..4843287 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type t : transporter; H+/gluconate symporter family protein 4843287 8194294 METDI4947 Methylobacterium extorquens DM4 H+/gluconate symporter family protein YP_003070375.1 4841896 D 661410 CDS YP_003070376.1 254563281 8194295 4843436..4844752 1 NC_012988.1 involved in the transport of C4-dicarboxylates across the membrane; C4-dicarboxylate transporter DctA 4844752 dctA 8194295 dctA Methylobacterium extorquens DM4 C4-dicarboxylate transporter DctA YP_003070376.1 4843436 D 661410 CDS YP_003070377.1 254563282 8195281 4844857..4845918 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative oxidoreductase 4845918 8195281 METDI4949 Methylobacterium extorquens DM4 putative oxidoreductase YP_003070377.1 4844857 D 661410 CDS YP_003070378.1 254563283 8194296 complement(4845945..4847660) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type e : enzyme; Aspartate ammonia-lyase (Aspartase) 4847660 aspA 8194296 aspA Methylobacterium extorquens DM4 Aspartate ammonia-lyase (Aspartase) YP_003070378.1 4845945 R 661410 CDS YP_003070379.1 254563284 8195110 complement(4847840..4849381) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4849381 8195110 METDI4951 Methylobacterium extorquens DM4 hypothetical protein YP_003070379.1 4847840 R 661410 CDS YP_003070380.1 254563285 8194297 4850072..4851754 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 1370281; Product type pt : putative transporter; putative porin 4851754 8194297 METDI4952 Methylobacterium extorquens DM4 putative porin YP_003070380.1 4850072 D 661410 CDS YP_003070381.1 254563286 8194298 4851956..4852867 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 10493123, 1091635, 1091636, 10972807, 8740179; Product type t : transporter; glutamate and aspartate transporter subunit ; periplasmic-binding component of ABC superfamily 4852867 gltI 8194298 gltI Methylobacterium extorquens DM4 glutamate and aspartate transporter subunit ; periplasmic-binding component of ABC superfamily YP_003070381.1 4851956 D 661410 CDS YP_003070382.1 254563287 8195514 4852902..4853624 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 11121068; Product type t : transporter; glutamate and aspartate transporter subunit ; membrane component of ABC superfamily 4853624 gltJ 8195514 gltJ Methylobacterium extorquens DM4 glutamate and aspartate transporter subunit ; membrane component of ABC superfamily YP_003070382.1 4852902 D 661410 CDS YP_003070383.1 254563288 8195515 4853624..4854316 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type t : transporter; glutamate/aspartate transport protein, ABC superfamily, permease component 4854316 glnP 8195515 glnP Methylobacterium extorquens DM4 glutamate/aspartate transport protein, ABC superfamily, permease component YP_003070383.1 4853624 D 661410 CDS YP_003070384.1 254563289 8195506 4854343..4855119 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 11121068; Product type t : transporter; glutamate and aspartate transporter subunit ; ATP-binding component of ABC superfamily 4855119 gltL 8195506 gltL Methylobacterium extorquens DM4 glutamate and aspartate transporter subunit ; ATP-binding component of ABC superfamily YP_003070384.1 4854343 D 661410 CDS YP_003070385.1 254563290 8195516 complement(4855209..4856162) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4856162 8195516 METDI4957 Methylobacterium extorquens DM4 hypothetical protein YP_003070385.1 4855209 R 661410 CDS YP_003070386.1 254563291 8194299 complement(4856198..4857466) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type t : transporter; arsenite/antimonite transporter 4857466 arsB 8194299 arsB Methylobacterium extorquens DM4 arsenite/antimonite transporter YP_003070386.1 4856198 R 661410 CDS YP_003070387.1 254563292 8195096 4857843..4858118 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4858118 8195096 METDI4959 Methylobacterium extorquens DM4 hypothetical protein YP_003070387.1 4857843 D 661410 CDS YP_003070388.1 254563293 8194300 complement(4858450..4859067) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 15188393, 16926146; hypothetical protein 4859067 8194300 METDI4960 Methylobacterium extorquens DM4 hypothetical protein YP_003070388.1 4858450 R 661410 CDS YP_003070389.1 254563294 8194301 4859328..4860107 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4860107 8194301 METDI4961 Methylobacterium extorquens DM4 hypothetical protein YP_003070389.1 4859328 D 661410 CDS YP_003070390.1 254563295 8194302 4860109..4861089 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4861089 8194302 METDI4962 Methylobacterium extorquens DM4 hypothetical protein YP_003070390.1 4860109 D 661410 CDS YP_003070391.1 254563296 8194303 4861101..4861994 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4861994 8194303 METDI4963 Methylobacterium extorquens DM4 hypothetical protein YP_003070391.1 4861101 D 661410 CDS YP_003070392.1 254563297 8194304 4862241..4866323 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative non-ribosomal peptide synthetase 4866323 8194304 METDI4964 Methylobacterium extorquens DM4 putative non-ribosomal peptide synthetase YP_003070392.1 4862241 D 661410 CDS YP_003070393.1 254563298 8194305 4866402..4866614 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4866614 8194305 METDI4965 Methylobacterium extorquens DM4 hypothetical protein YP_003070393.1 4866402 D 661410 CDS YP_003070394.1 254563299 8194306 4866614..4866892 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 1748867; hypothetical protein 4866892 8194306 METDI4966 Methylobacterium extorquens DM4 hypothetical protein YP_003070394.1 4866614 D 661410 CDS YP_003070395.1 254563300 8194307 complement(4866914..4867570) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4867570 8194307 METDI4967 Methylobacterium extorquens DM4 hypothetical protein YP_003070395.1 4866914 R 661410 CDS YP_003070396.1 254563301 8194308 4867831..4869003 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; cysteine desulfurase (tRNA sulfurtransferase), PLP-dependent 4869003 iscS 8194308 iscS Methylobacterium extorquens DM4 cysteine desulfurase (tRNA sulfurtransferase), PLP-dependent YP_003070396.1 4867831 D 661410 CDS YP_003070397.1 254563302 8195605 4869097..4870566 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type t : transporter; FeS assembly protein SufB 4870566 sufB 8195605 sufB Methylobacterium extorquens DM4 FeS assembly protein SufB YP_003070397.1 4869097 D 661410 CDS YP_003070398.1 254563303 8196170 4870855..4871607 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 10322040, 12089140; Product type t : transporter; FeS assembly ATPase SufC 4871607 sufC 8196170 sufC Methylobacterium extorquens DM4 FeS assembly ATPase SufC YP_003070398.1 4870855 D 661410 CDS YP_003070399.1 254563304 8196171 4871607..4872929 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type f : factor; FeS assembly protein SufD 4872929 sufD 8196171 sufD Methylobacterium extorquens DM4 FeS assembly protein SufD YP_003070399.1 4871607 D 661410 CDS YP_003070400.1 254563305 8196172 4873184..4874440 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 10684605, 12876288; Product type e : enzyme; cysteine desulfurase 4874440 sufS 8196172 sufS Methylobacterium extorquens DM4 cysteine desulfurase YP_003070400.1 4873184 D 661410 CDS YP_003070401.1 254563306 8196173 4874491..4874874 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4874874 8196173 METDI4973 Methylobacterium extorquens DM4 hypothetical protein YP_003070401.1 4874491 D 661410 CDS YP_003070402.1 254563307 8194309 complement(4874924..4875505) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4875505 8194309 METDI4974 Methylobacterium extorquens DM4 hypothetical protein YP_003070402.1 4874924 R 661410 CDS YP_003070403.1 254563308 8194310 4875687..4876067 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type f : factor; iron-sulfur cluster assembly accessory protein 4876067 8194310 METDI4975 Methylobacterium extorquens DM4 iron-sulfur cluster assembly accessory protein YP_003070403.1 4875687 D 661410 CDS YP_003070404.1 254563309 8194311 complement(4876164..4877231) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative diguanylate cyclase (2 GGDEF motifs) 4877231 8194311 METDI4976 Methylobacterium extorquens DM4 putative diguanylate cyclase (2 GGDEF motifs) YP_003070404.1 4876164 R 661410 CDS YP_003070405.1 254563310 8194312 complement(4877468..4879021) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; RNA helicase 4879021 rhlE 8194312 rhlE Methylobacterium extorquens DM4 RNA helicase YP_003070405.1 4877468 R 661410 CDS YP_003070406.1 254563311 8195990 complement(4879312..4879551) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4879551 8195990 METDI4978 Methylobacterium extorquens DM4 hypothetical protein YP_003070406.1 4879312 R 661410 CDS YP_003070407.1 254563312 8194313 4879906..4880772 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8589412, 8751924; Product type pm : putative membrane component; putative outer-membrane immunogenic protein precursor 4880772 8194313 METDI4979 Methylobacterium extorquens DM4 putative outer-membrane immunogenic protein precursor YP_003070407.1 4879906 D 661410 CDS YP_003070408.1 254563313 8194314 4881090..4881440 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 4881440 8194314 METDI4980 Methylobacterium extorquens DM4 hypothetical protein YP_003070408.1 4881090 D 661410 CDS YP_003070409.1 254563314 8194315 4881437..4881841 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4881841 8194315 METDI4981 Methylobacterium extorquens DM4 hypothetical protein YP_003070409.1 4881437 D 661410 CDS YP_003070410.1 254563315 8194316 4882001..4882273 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4882273 8194316 METDI4982 Methylobacterium extorquens DM4 hypothetical protein YP_003070410.1 4882001 D 661410 CDS YP_003070411.1 254563316 8194317 4882336..4882737 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4882737 8194317 METDI4983 Methylobacterium extorquens DM4 hypothetical protein YP_003070411.1 4882336 D 661410 CDS YP_003070412.1 254563317 8194318 4882936..4883226 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4883226 8194318 METDI4984 Methylobacterium extorquens DM4 hypothetical protein YP_003070412.1 4882936 D 661410 CDS YP_003070413.1 254563318 8194319 4883241..4883912 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative haloacid dehalogenase family hydrolase 4883912 8194319 METDI4985 Methylobacterium extorquens DM4 putative haloacid dehalogenase family hydrolase YP_003070413.1 4883241 D 661410 CDS YP_003070414.1 254563319 8194320 4884060..4884257 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4884257 8194320 METDI4986 Methylobacterium extorquens DM4 hypothetical protein YP_003070414.1 4884060 D 661410 CDS YP_003070415.1 254563320 8194321 complement(4884380..4885072) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative ABC transporter, ATPase 4885072 8194321 METDI4987 Methylobacterium extorquens DM4 putative ABC transporter, ATPase YP_003070415.1 4884380 R 661410 CDS YP_003070416.1 254563321 8194322 4885167..4885949 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative acyl-CoA thioesterase precursor (tesA-like) 4885949 8194322 METDI4988 Methylobacterium extorquens DM4 putative acyl-CoA thioesterase precursor (tesA-like) YP_003070416.1 4885167 D 661410 CDS YP_003070417.1 254563322 8194323 4885956..4886522 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8940112; Product type pe : putative enzyme; putative 2'-5' RNA ligase 4886522 8194323 METDI4989 Methylobacterium extorquens DM4 putative 2'-5' RNA ligase YP_003070417.1 4885956 D 661410 CDS YP_003070418.1 254563323 8196270 4886877..4887179 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative SecE subunit of protein translocation complex preprotein, (across inner membrane), (General Secretory Pathway) 4887179 8196270 METDI4990 Methylobacterium extorquens DM4 putative SecE subunit of protein translocation complex preprotein, (across inner membrane), (General Secretory Pathway) YP_003070418.1 4886877 D 661410 CDS YP_003070419.1 254563324 8194325 4887223..4887756 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 1532577, 2137819, 7505669, 8422985, 92112854, 92191277, 9571053, 10383769; Product type f : factor; transcription termination factor 4887756 nusG 8194325 nusG Methylobacterium extorquens DM4 transcription termination factor YP_003070419.1 4887223 D 661410 CDS YP_003070420.1 254563325 8195803 4887985..4888434 1 NC_012988.1 binds directly to 23S ribosomal RNA; 50S ribosomal protein L11 4888434 rplK 8195803 rplK Methylobacterium extorquens DM4 50S ribosomal protein L11 YP_003070420.1 4887985 D 661410 CDS YP_003070421.1 254563326 8196019 4888446..4889144 1 NC_012988.1 in Escherichia coli and Methanococcus, this protein autoregulates expression; the binding site in the mRNA mimics the binding site in the 23S rRNA; 50S ribosomal protein L1 4889144 rplA 8196019 rplA Methylobacterium extorquens DM4 50S ribosomal protein L1 YP_003070421.1 4888446 D 661410 CDS YP_003070422.1 254563327 8196012 complement(4889281..4890519) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 1732208; Product type pc : putative carrier; putative cytochrome P450 reductase 4890519 8196012 METDI4994 Methylobacterium extorquens DM4 putative cytochrome P450 reductase YP_003070422.1 4889281 R 661410 CDS YP_003070423.1 254563328 8194326 complement(4890524..4891786) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 1569021, 7836301, 8344526; Product type pe : putative enzyme; putative NAD(FAD)-dependent oxidoreductase 4891786 8194326 METDI4995 Methylobacterium extorquens DM4 putative NAD(FAD)-dependent oxidoreductase YP_003070423.1 4890524 R 661410 CDS YP_003070424.1 254563329 8194327 complement(4891783..4892004) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 7126685, 7803404, 9533888; Product type pf : putative factor; putative Ferredoxin; putative 4Fe-4S ferredoxins domain 4892004 8194327 METDI4996 Methylobacterium extorquens DM4 putative Ferredoxin; putative 4Fe-4S ferredoxins domain YP_003070424.1 4891783 R 661410 CDS YP_003070425.1 254563330 8194328 complement(4892159..4893241) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4893241 8194328 METDI4997 Methylobacterium extorquens DM4 hypothetical protein YP_003070425.1 4892159 R 661410 CDS YP_003070426.1 254563331 8194329 complement(4893238..4894122) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15294902, 7512872, 7517390; Product type pe : putative enzyme; putative glycosyl transferase 4894122 8194329 METDI4998 Methylobacterium extorquens DM4 putative glycosyl transferase YP_003070426.1 4893238 R 661410 CDS YP_003070427.1 254563332 8194330 complement(4894271..4896085) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; aspartate tRNA synthetase 4896085 aspS 8194330 aspS Methylobacterium extorquens DM4 aspartate tRNA synthetase YP_003070427.1 4894271 R 661410 CDS YP_003070428.1 254563333 8195111 complement(4896187..4897194) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 11834738, 12475249, 14704425, 14967041; Product type e : enzyme; biotin synthetase 4897194 bioB 8195111 bioB Methylobacterium extorquens DM4 biotin synthetase YP_003070428.1 4896187 R 661410 CDS YP_003070429.1 254563334 8195142 4897388..4897774 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4897774 8195142 METDI5001 Methylobacterium extorquens DM4 hypothetical protein YP_003070429.1 4897388 D 661410 CDS YP_003070430.1 254563335 8194331 complement(4897860..4898744) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; 2-hydroxyhepta-2,4-diene-1, 7-dioate isomerase/5-carboxymethyl-2-oxo-hex-3-ene-1, 7-dioate decarboxylase 4898744 hpaG 8194331 hpaG Methylobacterium extorquens DM4 2-hydroxyhepta-2,4-diene-1, 7-dioate isomerase/5-carboxymethyl-2-oxo-hex-3-ene-1, 7-dioate decarboxylase YP_003070430.1 4897860 R 661410 CDS YP_003070431.1 254563336 8195572 4898998..4900323 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative long-chain fatty acid outer membrane transporter (fadL) 4900323 8195572 METDI5003 Methylobacterium extorquens DM4 putative long-chain fatty acid outer membrane transporter (fadL) YP_003070431.1 4898998 D 661410 CDS YP_003070432.1 254563337 8194332 complement(4900481..4901281) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4901281 8194332 METDI5004 Methylobacterium extorquens DM4 hypothetical protein YP_003070432.1 4900481 R 661410 CDS YP_003070433.1 254563338 8194333 4901682..4904135 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative diguanylate cyclase (GGDEF) /phosphodiesterase (EAL) with PAS sensor 4904135 8194333 METDI5005 Methylobacterium extorquens DM4 putative diguanylate cyclase (GGDEF) /phosphodiesterase (EAL) with PAS sensor YP_003070433.1 4901682 D 661410 CDS YP_003070434.1 254563339 8194334 complement(4904236..4905879) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4905879 8194334 METDI5006 Methylobacterium extorquens DM4 hypothetical protein YP_003070434.1 4904236 R 661410 CDS YP_003070435.1 254563340 8194335 4906653..4908161 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4908161 8194335 METDI5007 Methylobacterium extorquens DM4 hypothetical protein YP_003070435.1 4906653 D 661410 CDS YP_003070436.1 254563341 8194336 complement(4908205..4908354) 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 4908354 8194336 METDI5008 Methylobacterium extorquens DM4 hypothetical protein YP_003070436.1 4908205 R 661410 CDS YP_003070437.1 254563342 8194337 4909029..4909547 1 NC_012988.1 binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit; 50S ribosomal protein L10 4909547 rplJ 8194337 rplJ Methylobacterium extorquens DM4 50S ribosomal protein L10 YP_003070437.1 4909029 D 661410 CDS YP_003070438.1 254563343 8196018 4909605..4909982 1 NC_012988.1 present in two forms; L12 is normal, while L7 is aminoacylated at the N-terminal serine; the only multicopy ribosomal protein; 4:1 ratio of L7/L12 per ribosome; two L12 dimers bind L10; critically important for translation efficiency and fidelity; stimulates GTPase activity of translation factors; 50S ribosomal protein L7/L12 4909982 rplL 8196018 rplL Methylobacterium extorquens DM4 50S ribosomal protein L7/L12 YP_003070438.1 4909605 D 661410 CDS YP_003070439.1 254563344 8196021 4910244..4914374 1 NC_012988.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme; DNA-directed RNA polymerase subunit beta 4914374 rpoB 8196021 rpoB Methylobacterium extorquens DM4 DNA-directed RNA polymerase subunit beta YP_003070439.1 4910244 D 661410 CDS YP_003070440.1 254563345 8196045 4914553..4918770 1 NC_012988.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Subunit beta' binds to sigma factor allowing it to bind to the -10 region of the promoter; DNA-directed RNA polymerase subunit beta' 4918770 rpoC 8196045 rpoC Methylobacterium extorquens DM4 DNA-directed RNA polymerase subunit beta' YP_003070440.1 4914553 D 661410 CDS YP_003070441.1 254563346 8196046 complement(4919004..4920104) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 8416922, 9298646, 93106992, 9651355; Product type t : transporter; putrescine transporter subunit: periplasmic-binding component of ABC superfamily 4920104 potF 8196046 potF Methylobacterium extorquens DM4 putrescine transporter subunit: periplasmic-binding component of ABC superfamily YP_003070441.1 4919004 R 661410 CDS YP_003070442.1 254563347 8195875 complement(4920101..4920460) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4920460 8195875 METDI5014 Methylobacterium extorquens DM4 hypothetical protein YP_003070442.1 4920101 R 661410 CDS YP_003070443.1 254563348 8190536 4920711..4920977 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4920977 8190536 METDI5015 Methylobacterium extorquens DM4 hypothetical protein YP_003070443.1 4920711 D 661410 CDS YP_003070444.1 254563349 8194339 4921643..4922125 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcriptional regulator, HxlR family 4922125 8194339 METDI5016 Methylobacterium extorquens DM4 putative transcriptional regulator, HxlR family YP_003070444.1 4921643 D 661410 CDS YP_003070445.1 254563350 8194340 complement(4922191..4922424) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4922424 8194340 METDI5017 Methylobacterium extorquens DM4 hypothetical protein YP_003070445.1 4922191 R 661410 CDS YP_003070446.1 254563351 8194341 complement(4922506..4923147) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative glutathione S-transferase 4923147 8194341 METDI5018 Methylobacterium extorquens DM4 putative glutathione S-transferase YP_003070446.1 4922506 R 661410 CDS YP_003070447.1 254563352 8194342 complement(4923240..4925480) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type prc : putative receptor; putative TonB-dependent iron outer membrane transporter (fiu) 4925480 8194342 METDI5019 Methylobacterium extorquens DM4 putative TonB-dependent iron outer membrane transporter (fiu) YP_003070447.1 4923240 R 661410 CDS YP_003070448.1 254563353 8194343 complement(4925728..4927974) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type e : enzyme; polynucleotide phosphorylase/polyadenylase 4927974 pnp 8194343 pnp Methylobacterium extorquens DM4 polynucleotide phosphorylase/polyadenylase YP_003070448.1 4925728 R 661410 CDS YP_003070449.1 254563354 8195870 complement(4928244..4928513) 1 NC_012988.1 primary rRNA binding protein; helps nucleate assembly of 30S; binds directly to the 16S rRNA and an intersubunit bridge to the 23S rRNA; autoregulates translation through interactions with the mRNA leader sequence; 30S ribosomal protein S15 4928513 rpsO 8195870 rpsO Methylobacterium extorquens DM4 30S ribosomal protein S15 YP_003070449.1 4928244 R 661410 CDS YP_003070450.1 254563355 8196066 4928813..4930279 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type t : transporter; Amino acid transporter 4930279 8196066 METDI5022 Methylobacterium extorquens DM4 Amino acid transporter YP_003070450.1 4928813 D 661410 CDS YP_003070451.1 254563356 8194344 complement(4930342..4930455) 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 4930455 8194344 METDI5023 Methylobacterium extorquens DM4 hypothetical protein YP_003070451.1 4930342 R 661410 CDS YP_003070452.1 254563357 8194345 complement(4930525..4931334) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 3049539; Product type e : enzyme; Exodeoxyribonuclease III (Exonuclease III) (EXO III) (AP endonuclease VI) 4931334 xthA 8194345 xthA Methylobacterium extorquens DM4 Exodeoxyribonuclease III (Exonuclease III) (EXO III) (AP endonuclease VI) YP_003070452.1 4930525 R 661410 CDS YP_003070453.1 254563358 8196346 complement(4931403..4931849) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor; putative activator of photopigment and puc with BLUF domain 4931849 8196346 METDI5025 Methylobacterium extorquens DM4 putative activator of photopigment and puc with BLUF domain YP_003070453.1 4931403 R 661410 CDS YP_003070454.1 254563359 8194346 complement(4931866..4933569) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11843302; Product type pe : putative enzyme; putative diguanylate cyclase (GGDEF) /phosphodiesterase (EAL) precursor with PAS sensor 4933569 8194346 METDI5026 Methylobacterium extorquens DM4 putative diguanylate cyclase (GGDEF) /phosphodiesterase (EAL) precursor with PAS sensor YP_003070454.1 4931866 R 661410 CDS YP_003070455.1 254563360 8194347 complement(4933788..4934735) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4934735 8194347 METDI5027 Methylobacterium extorquens DM4 hypothetical protein YP_003070455.1 4933788 R 661410 CDS YP_003070456.1 254563361 8194348 complement(4934915..4938208) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type cp : cell process; Cell division protein 4938208 ftsK 8194348 ftsK Methylobacterium extorquens DM4 Cell division protein YP_003070456.1 4934915 R 661410 CDS YP_003070457.1 254563362 8195454 4938646..4940718 1 NC_012988.1 catalyzes the formation of nicotinamide adenine dinucleotide (NAD) from nicotinic acid adenine dinucleotide (NAAD) using either ammonia or glutamine as the amide donor and ATP; ammonia-utilizing enzymes include the ones from Bacillus and Escherichia coli while glutamine-utilizing enzymes include the Mycobacterial one; forms homodimers; NAD synthetase 4940718 nadE 8195454 nadE Methylobacterium extorquens DM4 NAD synthetase YP_003070457.1 4938646 D 661410 CDS YP_003070458.1 254563363 8195769 complement(4940742..4941206) 1 NC_012988.1 LovR from Caulobacter crescentus is a response regulator part of a two-component signaling system that regulates photosensitive bacterial cell-surface and cell-cell attachment; response regulator 4941206 8195769 METDI5030 Methylobacterium extorquens DM4 response regulator YP_003070458.1 4940742 R 661410 CDS YP_003070459.1 254563364 8194349 complement(4941340..4942395) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative histidine kinase, domains HK, ATPase and sensory PAS 4942395 8194349 METDI5031 Methylobacterium extorquens DM4 putative histidine kinase, domains HK, ATPase and sensory PAS YP_003070459.1 4941340 R 661410 CDS YP_003070460.1 254563365 8194350 4942832..4944280 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative transport transmembrane protein, AmpG 4944280 8194350 METDI5032 Methylobacterium extorquens DM4 putative transport transmembrane protein, AmpG YP_003070460.1 4942832 D 661410 CDS YP_003070461.1 254563366 8194351 4944277..4945203 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4945203 8194351 METDI5033 Methylobacterium extorquens DM4 hypothetical protein YP_003070461.1 4944277 D 661410 CDS YP_003070462.1 254563367 8194352 complement(4945389..4946573) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4946573 8194352 METDI5034 Methylobacterium extorquens DM4 hypothetical protein YP_003070462.1 4945389 R 661410 CDS YP_003070463.1 254563368 8194353 4946654..4947259 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4947259 8194353 METDI5035 Methylobacterium extorquens DM4 hypothetical protein YP_003070463.1 4946654 D 661410 CDS YP_003070464.1 254563369 8194354 4947650..4948360 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4948360 8194354 METDI5036 Methylobacterium extorquens DM4 hypothetical protein YP_003070464.1 4947650 D 661410 CDS YP_003070465.1 254563370 8194355 4948447..4949787 1 NC_012988.1 EngA; essential Neisserial GTPase; synchronizes cellular events by interacting with multiple targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide binding affinities in the two binding domains; GTP-binding protein EngA 4949787 engA 8194355 engA Methylobacterium extorquens DM4 GTP-binding protein EngA YP_003070465.1 4948447 D 661410 CDS YP_003070466.1 254563371 8195329 4949956..4950858 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4950858 8195329 METDI5038 Methylobacterium extorquens DM4 hypothetical protein YP_003070466.1 4949956 D 661410 CDS YP_003070467.1 254563372 8194356 complement(4950862..4951986) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4951986 8194356 METDI5039 Methylobacterium extorquens DM4 hypothetical protein YP_003070467.1 4950862 R 661410 CDS YP_003070468.1 254563373 8194357 4952226..4953125 1 NC_012988.1 Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases; formamidopyrimidine-DNA glycosylase 4953125 mutM 8194357 mutM Methylobacterium extorquens DM4 formamidopyrimidine-DNA glycosylase YP_003070468.1 4952226 D 661410 CDS YP_003070469.1 254563374 8195745 4953346..4953549 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4953549 8195745 METDI5041 Methylobacterium extorquens DM4 hypothetical protein YP_003070469.1 4953346 D 661410 CDS YP_003070470.1 254563375 8194358 4953712..4954176 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcriptional regulator, BadM/Rrf2 family 4954176 8194358 METDI5042 Methylobacterium extorquens DM4 putative transcriptional regulator, BadM/Rrf2 family YP_003070470.1 4953712 D 661410 CDS YP_003070471.1 254563376 8194359 4954166..4955074 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type e : enzyme; putative FAD-dependent pyridine nucleotide-disulphide oxidoreductase 4955074 8194359 METDI5043 Methylobacterium extorquens DM4 putative FAD-dependent pyridine nucleotide-disulphide oxidoreductase YP_003070471.1 4954166 D 661410 CDS YP_003070472.1 254563377 8194360 4955370..4956929 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier; putative Penicillin-binding protein 4956929 8194360 METDI5044 Methylobacterium extorquens DM4 putative Penicillin-binding protein YP_003070472.1 4955370 D 661410 CDS YP_003070473.1 254563378 8194361 complement(4957021..4959348) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative hybrid histidine kinase with multiple PAS and a response regulator receiver domain 4959348 8194361 METDI5045 Methylobacterium extorquens DM4 putative hybrid histidine kinase with multiple PAS and a response regulator receiver domain YP_003070473.1 4957021 R 661410 CDS YP_003070474.1 254563379 8194362 complement(4959478..4960206) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative glutathione S-transferase 4960206 8194362 METDI5046 Methylobacterium extorquens DM4 putative glutathione S-transferase YP_003070474.1 4959478 R 661410 CDS YP_003070475.1 254563380 8194363 complement(4960226..4960903) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4960903 8194363 METDI5047 Methylobacterium extorquens DM4 hypothetical protein YP_003070475.1 4960226 R 661410 CDS YP_003070476.1 254563381 8194364 complement(4960993..4961304) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4961304 8194364 METDI5048 Methylobacterium extorquens DM4 hypothetical protein YP_003070476.1 4960993 R 661410 CDS YP_003070477.1 254563382 8194365 complement(4961422..4964148) 1 NC_012988.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpin of the Uvr-B subunit is inserted between the strands, where it probes for the presence of a lesion; excinuclease ABC subunit B 4964148 uvrB 8194365 uvrB Methylobacterium extorquens DM4 excinuclease ABC subunit B YP_003070477.1 4961422 R 661410 CDS YP_003070478.1 254563383 8196330 4964295..4964543 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 7961423; Product type f : factor; prevent-host-death protein 4964543 8196330 METDI5050 Methylobacterium extorquens DM4 prevent-host-death protein YP_003070478.1 4964295 D 661410 CDS YP_003070479.1 254563384 8194366 4964540..4964926 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4964926 8194366 METDI5051 Methylobacterium extorquens DM4 hypothetical protein YP_003070479.1 4964540 D 661410 CDS YP_003070480.1 254563385 8194367 complement(4964933..4965844) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type r : regulator; transcriptional regulator, LysR family 4965844 8194367 METDI5052 Methylobacterium extorquens DM4 transcriptional regulator, LysR family YP_003070480.1 4964933 R 661410 CDS YP_003070481.1 254563386 8194368 4965966..4966361 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4966361 8194368 METDI5053 Methylobacterium extorquens DM4 hypothetical protein YP_003070481.1 4965966 D 661410 CDS YP_003070482.1 254563387 8194369 4966402..4966884 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative Biphenyl-2,3-diol 1,2-dioxygenase III 4966884 8194369 METDI5054 Methylobacterium extorquens DM4 putative Biphenyl-2,3-diol 1,2-dioxygenase III YP_003070482.1 4966402 D 661410 CDS YP_003070483.1 254563388 8194370 4966963..4967640 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4967640 8194370 METDI5055 Methylobacterium extorquens DM4 hypothetical protein YP_003070483.1 4966963 D 661410 CDS YP_003070484.1 254563389 8194371 4967576..4968070 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4968070 8194371 METDI5056 Methylobacterium extorquens DM4 hypothetical protein YP_003070484.1 4967576 D 661410 CDS YP_003070485.1 254563390 8194372 4968190..4968852 1 NC_012988.1 catalyzes the formation of undecaprenyl pyrophosphate from isopentenyl pyrophosphate; undecaprenyl pyrophosphate synthase 4968852 uppS 8194372 uppS Methylobacterium extorquens DM4 undecaprenyl pyrophosphate synthase YP_003070485.1 4968190 D 661410 CDS YP_003070486.1 254563391 8196307 4968942..4970468 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; Magnesium-protoporphyrin IX monomethyl ester [oxidative] cyclase (Mg-protoporphyrin IX monomethyl ester oxidative cyclase) 4970468 bchE 8196307 bchE Methylobacterium extorquens DM4 Magnesium-protoporphyrin IX monomethyl ester [oxidative] cyclase (Mg-protoporphyrin IX monomethyl ester oxidative cyclase) YP_003070486.1 4968942 D 661410 CDS YP_003070487.1 254563392 8195128 4970540..4971082 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4971082 8195128 METDI5059 Methylobacterium extorquens DM4 hypothetical protein YP_003070487.1 4970540 D 661410 CDS YP_003070488.1 254563393 8194373 4971170..4972675 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 10090737, 8170944, 9817843, 9843423; Product type e : enzyme; glycerol kinase 4972675 glpK 8194373 glpK Methylobacterium extorquens DM4 glycerol kinase YP_003070488.1 4971170 D 661410 CDS YP_003070489.1 254563394 8195508 4972723..4973838 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; hypothetical protein 4973838 8195508 METDI5061 Methylobacterium extorquens DM4 hypothetical protein YP_003070489.1 4972723 D 661410 CDS YP_003070490.1 254563395 8194374 4974044..4975729 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type prc : putative receptor; putative methyl-accepting chemotaxis sensory transducer 4975729 8194374 METDI5062 Methylobacterium extorquens DM4 putative methyl-accepting chemotaxis sensory transducer YP_003070490.1 4974044 D 661410 CDS YP_003070491.1 254563396 8194375 complement(4975795..4976556) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative glycerophosphoryl diester phosphodiesterase 4976556 8194375 METDI5063 Methylobacterium extorquens DM4 putative glycerophosphoryl diester phosphodiesterase YP_003070491.1 4975795 R 661410 CDS YP_003070492.1 254563397 8194376 complement(4976553..4977026) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; Endoribonuclease L-PSP 4977026 8194376 METDI5064 Methylobacterium extorquens DM4 Endoribonuclease L-PSP YP_003070492.1 4976553 R 661410 CDS YP_003070493.1 254563398 8194377 complement(4977299..4979470) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11679081, 2249654, 9743528, 9864332; Product type pt : putative transporter; putative bacteriocin/pheromone secretion/processing ATP-binding protein 4979470 8194377 METDI5065 Methylobacterium extorquens DM4 putative bacteriocin/pheromone secretion/processing ATP-binding protein YP_003070493.1 4977299 R 661410 CDS YP_003070494.1 254563399 8194378 complement(4979467..4980756) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; putative secretion protein 4980756 8194378 METDI5066 Methylobacterium extorquens DM4 putative secretion protein YP_003070494.1 4979467 R 661410 CDS YP_003070495.1 254563400 8194379 4981233..4981445 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4981445 8194379 METDI5067 Methylobacterium extorquens DM4 hypothetical protein YP_003070495.1 4981233 D 661410 CDS YP_003070496.1 254563401 8194380 4981780..4982682 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4982682 8194380 METDI5068 Methylobacterium extorquens DM4 hypothetical protein YP_003070496.1 4981780 D 661410 CDS YP_003070497.1 254563402 8194381 4982896..4984086 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type e : enzyme; succinylornithine transaminase, also has acetylornitine transaminase activity, PLP-dependent 4984086 argD 8194381 argD Methylobacterium extorquens DM4 succinylornithine transaminase, also has acetylornitine transaminase activity, PLP-dependent YP_003070497.1 4982896 D 661410 CDS YP_003070498.1 254563403 8195085 4984073..4985065 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type e : enzyme; ornithine carbamoyltransferase 4985065 argF 8195085 argF Methylobacterium extorquens DM4 ornithine carbamoyltransferase YP_003070498.1 4984073 D 661410 CDS YP_003070499.1 254563404 8195087 complement(4985124..4985363) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4985363 8195087 METDI5071 Methylobacterium extorquens DM4 hypothetical protein YP_003070499.1 4985124 R 661410 CDS YP_003070500.1 254563405 8194382 complement(4985508..4985975) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4985975 8194382 METDI5072 Methylobacterium extorquens DM4 hypothetical protein YP_003070500.1 4985508 R 661410 CDS YP_003070501.1 254563406 8194383 complement(4985995..4986417) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4986417 8194383 METDI5073 Methylobacterium extorquens DM4 hypothetical protein YP_003070501.1 4985995 R 661410 CDS YP_003070502.1 254563407 8194384 4986703..4987509 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 1556094, 9100384; Product type pe : putative enzyme; putative 3-ketoacyl-acyl carrier protein reductase (fabG-like) 4987509 8194384 METDI5074 Methylobacterium extorquens DM4 putative 3-ketoacyl-acyl carrier protein reductase (fabG-like) YP_003070502.1 4986703 D 661410 CDS YP_003070503.1 254563408 8194385 4987513..4988895 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 1339281, 1581034; Product type pe : putative enzyme; putative dihydrolipoamide dehydrogenase 4988895 8194385 METDI5075 Methylobacterium extorquens DM4 putative dihydrolipoamide dehydrogenase YP_003070503.1 4987513 D 661410 CDS YP_003070504.1 254563409 8194386 4989119..4991746 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative Bacteriophytochrome (light-regulated signal transduction histidine kinase), PhyB2 4991746 8194386 METDI5076 Methylobacterium extorquens DM4 putative Bacteriophytochrome (light-regulated signal transduction histidine kinase), PhyB2 YP_003070504.1 4989119 D 661410 CDS YP_003070505.1 254563410 8194387 4991754..4992311 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative Heme oxygenase (BphO-like) 4992311 8194387 METDI5077 Methylobacterium extorquens DM4 putative Heme oxygenase (BphO-like) YP_003070505.1 4991754 D 661410 CDS YP_003070506.1 254563411 8194388 complement(4992377..4993537) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4993537 8194388 METDI5078 Methylobacterium extorquens DM4 hypothetical protein YP_003070506.1 4992377 R 661410 CDS YP_003070507.1 254563412 8194389 complement(4993530..4994012) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4994012 8194389 METDI5079 Methylobacterium extorquens DM4 hypothetical protein YP_003070507.1 4993530 R 661410 CDS YP_003070508.1 254563413 8194390 4994268..4995614 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative capsule polysaccharide export inner-membrane protein (kpsE-like) 4995614 8194390 METDI5080 Methylobacterium extorquens DM4 putative capsule polysaccharide export inner-membrane protein (kpsE-like) YP_003070508.1 4994268 D 661410 CDS YP_003070509.1 254563414 8194391 4995769..4996053 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4996053 8194391 METDI5081 Methylobacterium extorquens DM4 hypothetical protein YP_003070509.1 4995769 D 661410 CDS YP_003070510.1 254563415 8194392 4996245..4997225 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4997225 8194392 METDI5082 Methylobacterium extorquens DM4 hypothetical protein YP_003070510.1 4996245 D 661410 CDS YP_003070511.1 254563416 8194393 complement(4997258..4998631) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 17572072, 2315326; Product type r : regulator; two-component flagellar sigma-54 dependent transcriptional regulator, Fis family 4998631 flbD 8194393 flbD Methylobacterium extorquens DM4 two-component flagellar sigma-54 dependent transcriptional regulator, Fis family YP_003070511.1 4997258 R 661410 CDS YP_003070512.1 254563417 8195387 complement(4998785..4999132) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 1732219, 2315326, 8002583; Product type s : structure; flagellar motor switch protein 4999132 fliY 8195387 fliY Methylobacterium extorquens DM4 flagellar motor switch protein YP_003070512.1 4998785 R 661410 CDS YP_003070513.1 254563418 8195431 complement(4999138..4999764) 1 NC_012988.1 binds to and inhibits the function of flagella specific ATPase FliI; flagellar assembly protein H 4999764 fliH 8195431 fliH Methylobacterium extorquens DM4 flagellar assembly protein H YP_003070513.1 4999138 R 661410 CDS YP_003070514.1 254563419 8194394 complement(4999761..5000816) 1 NC_012988.1 One of three proteins involved in switching the direction of the flagellar rotation; flagellar motor switch protein G 5000816 fliG 8194394 fliG Methylobacterium extorquens DM4 flagellar motor switch protein G YP_003070514.1 4999761 R 661410 CDS YP_003070515.1 254563420 8195418 complement(5000860..5002482) 1 NC_012988.1 the MS-ring anchors the flagellum to the cytoplasmic membrane; part of the flagellar basal body which consists of four rings L, P, S, and M mounted on a central rod; flagellar MS-ring protein 5002482 fliF 8195418 fliF Methylobacterium extorquens DM4 flagellar MS-ring protein YP_003070515.1 5000860 R 661410 CDS YP_003070516.1 254563421 8195416 complement(5002743..5003018) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5003018 8195416 METDI5088 Methylobacterium extorquens DM4 hypothetical protein YP_003070516.1 5002743 R 661410 CDS YP_003070517.1 254563422 8194395 complement(5003160..5003840) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure; putative flagellar basal-body rod modification protein (Synonyms : FlgD flaV, fla FIV, fla FVI) 5003840 8194395 METDI5089 Methylobacterium extorquens DM4 putative flagellar basal-body rod modification protein (Synonyms : FlgD flaV, fla FIV, fla FVI) YP_003070517.1 5003160 R 661410 CDS YP_003070518.1 254563423 8194396 complement(5003850..5005310) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor; putative flagellar hook length determination protein 5005310 8194396 METDI5090 Methylobacterium extorquens DM4 putative flagellar hook length determination protein YP_003070518.1 5003850 R 661410 CDS YP_003070519.1 254563424 8194397 5005509..5006741 1 NC_012988.1 catalyzes a sulfuration reaction to synthesize 2-thiouridine at the U34 position of tRNAs; tRNA-specific 2-thiouridylase MnmA 5006741 mnmA 8194397 mnmA Methylobacterium extorquens DM4 tRNA-specific 2-thiouridylase MnmA YP_003070519.1 5005509 D 661410 CDS YP_003070520.1 254563425 8196213 5006997..5007653 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative phosphatidylethanolamine-N-methyltransferase (pmtA) 5007653 8196213 METDI5092 Methylobacterium extorquens DM4 putative phosphatidylethanolamine-N-methyltransferase (pmtA) YP_003070520.1 5006997 D 661410 CDS YP_003070521.1 254563426 8194398 5007692..5008540 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5008540 8194398 METDI5093 Methylobacterium extorquens DM4 hypothetical protein YP_003070521.1 5007692 D 661410 CDS YP_003070522.1 254563427 8194399 5008714..5010198 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type prc : putative receptor; putative integral membrane sensor signal transduction histidine kinase 5010198 8194399 METDI5094 Methylobacterium extorquens DM4 putative integral membrane sensor signal transduction histidine kinase YP_003070522.1 5008714 D 661410 CDS YP_003070523.1 254563428 8194401 complement(5011312..5012889) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type t : transporter; multidrug efflux system protein 5012889 emrB 8194401 emrB Methylobacterium extorquens DM4 multidrug efflux system protein YP_003070523.1 5011312 R 661410 CDS YP_003070524.1 254563429 8195328 complement(5013086..5014291) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 1409590; Product type pt : putative transporter; putative multidrug resistance secretion protein (emrA-like) 5014291 8195328 METDI5097 Methylobacterium extorquens DM4 putative multidrug resistance secretion protein (emrA-like) YP_003070524.1 5013086 R 661410 CDS YP_003070525.1 254563430 8194402 5014432..5015094 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type r : regulator; transcriptional regulator, TetR family 5015094 8194402 METDI5098 Methylobacterium extorquens DM4 transcriptional regulator, TetR family YP_003070525.1 5014432 D 661410 CDS YP_003070526.1 254563431 8194403 complement(5015101..5016864) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 12039753; Product type e : enzyme; acyl-CoA dehydrogenase 5016864 8194403 METDI5099 Methylobacterium extorquens DM4 acyl-CoA dehydrogenase YP_003070526.1 5015101 R 661410 CDS YP_003070527.1 254563432 8194404 5016975..5017964 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5017964 8194404 METDI5100 Methylobacterium extorquens DM4 hypothetical protein YP_003070527.1 5016975 D 661410 CDS YP_003070528.1 254563433 8194405 complement(5018134..5019948) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative hybrid histidine kinase; HK, ATPase, PAS and a response regulator receiver domain 5019948 8194405 METDI5101 Methylobacterium extorquens DM4 putative hybrid histidine kinase; HK, ATPase, PAS and a response regulator receiver domain YP_003070528.1 5018134 R 661410 CDS YP_003070529.1 254563434 8194406 complement(5019887..5020222) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 12622725, 12727878, 12727879, 14709675, 15071498, 15170179; Product type e : enzyme; thiol disulfide isomerase 5020222 8194406 METDI5102 Methylobacterium extorquens DM4 thiol disulfide isomerase YP_003070529.1 5019887 R 661410 CDS YP_003070530.1 254563435 8194407 complement(5020219..5020626) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 12622725, 12727878, 12727879, 14709675, 15071498, 15170179; Product type e : enzyme; thiol disulfide isomerase 5020626 8194407 METDI5103 Methylobacterium extorquens DM4 thiol disulfide isomerase YP_003070530.1 5020219 R 661410 CDS YP_003070531.1 254563436 8194408 complement(5020623..5022350) 1 NC_012988.1 acts as a promotor non-specific transcription repressor; circadian clock protein KaiC 5022350 8194408 METDI5104 Methylobacterium extorquens DM4 circadian clock protein KaiC YP_003070531.1 5020623 R 661410 CDS YP_003070532.1 254563437 8194409 5022767..5023153 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative response regulator receiver (CheY-like protein) 5023153 8194409 METDI5105 Methylobacterium extorquens DM4 putative response regulator receiver (CheY-like protein) YP_003070532.1 5022767 D 661410 CDS YP_003070533.1 254563438 8194410 complement(5023176..5024522) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type prc : putative receptor; putative integral membrane sensor signal transduction histidine kinase precursor 5024522 8194410 METDI5106 Methylobacterium extorquens DM4 putative integral membrane sensor signal transduction histidine kinase precursor YP_003070533.1 5023176 R 661410 CDS YP_003070534.1 254563439 8194411 complement(5024519..5025184) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative phoP: DNA-binding response regulator in two-component regulatory system with PhoQ 5025184 8194411 METDI5107 Methylobacterium extorquens DM4 putative phoP: DNA-binding response regulator in two-component regulatory system with PhoQ YP_003070534.1 5024519 R 661410 CDS YP_003070535.1 254563440 8194412 complement(5025209..5025541) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 5025541 8194412 METDI5108 Methylobacterium extorquens DM4 hypothetical protein YP_003070535.1 5025209 R 661410 CDS YP_003070536.1 254563441 8194413 5025708..5026343 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 5026343 8194413 METDI5109 Methylobacterium extorquens DM4 hypothetical protein YP_003070536.1 5025708 D 661410 CDS YP_003070537.1 254563442 8194414 complement(5026359..5026652) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 5026652 8194414 METDI5110 Methylobacterium extorquens DM4 hypothetical protein YP_003070537.1 5026359 R 661410 CDS YP_003070538.1 254563443 8194415 complement(5026652..5027002) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5027002 8194415 METDI5111 Methylobacterium extorquens DM4 hypothetical protein YP_003070538.1 5026652 R 661410 CDS YP_003070539.1 254563444 8194416 complement(5026999..5028591) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5028591 8194416 METDI5112 Methylobacterium extorquens DM4 hypothetical protein YP_003070539.1 5026999 R 661410 CDS YP_003070540.1 254563445 8194417 complement(5028588..5028902) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5028902 8194417 METDI5113 Methylobacterium extorquens DM4 hypothetical protein YP_003070540.1 5028588 R 661410 CDS YP_003070541.1 254563446 8194418 complement(5028912..5031269) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type prc : putative receptor; putative TonB-dependent siderophore receptor 5031269 8194418 METDI5114 Methylobacterium extorquens DM4 putative TonB-dependent siderophore receptor YP_003070541.1 5028912 R 661410 CDS YP_003070542.1 254563447 8194419 complement(5031511..5031789) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 5031789 8194419 METDI5115 Methylobacterium extorquens DM4 hypothetical protein YP_003070542.1 5031511 R 661410 CDS YP_003070543.1 254563448 8194420 complement(5032207..5032377) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 5032377 8194420 METDI5116 Methylobacterium extorquens DM4 hypothetical protein YP_003070543.1 5032207 R 661410 CDS YP_003070544.1 254563449 8194421 5032437..5032628 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; PubMedId : 9163424; hypothetical protein 5032628 8194421 METDI5117 Methylobacterium extorquens DM4 hypothetical protein YP_003070544.1 5032437 D 661410 CDS YP_003070545.1 254563450 8194422 5033142..5038703 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 5038703 8194422 METDI5118 Methylobacterium extorquens DM4 hypothetical protein YP_003070545.1 5033142 D 661410 CDS YP_003070546.1 254563451 8194423 5038781..5040304 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative Phosphomannomutase/phosphoglucomutase (AlgC) 5040304 8194423 METDI5119 Methylobacterium extorquens DM4 putative Phosphomannomutase/phosphoglucomutase (AlgC) YP_003070546.1 5038781 D 661410 CDS YP_003070547.1 254563452 8194424 5040714..5042207 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 5042207 8194424 METDI5120 Methylobacterium extorquens DM4 hypothetical protein YP_003070547.1 5040714 D 661410 CDS YP_003070548.1 254563453 8194425 5042583..5044010 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 5044010 8194425 METDI5121 Methylobacterium extorquens DM4 hypothetical protein YP_003070548.1 5042583 D 661410 CDS YP_003070549.1 254563454 8194426 complement(5044164..5044424) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 5044424 8194426 METDI5122 Methylobacterium extorquens DM4 hypothetical protein YP_003070549.1 5044164 R 661410 CDS YP_003070550.1 254563455 8194427 complement(5044424..5046628) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative Tyrosine-protein kinase etk 5046628 8194427 METDI5123 Methylobacterium extorquens DM4 putative Tyrosine-protein kinase etk YP_003070550.1 5044424 R 661410 CDS YP_003070551.1 254563456 8194428 complement(5046699..5048222) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative Undecaprenyl-phosphate galactosephosphotransferase 5048222 8194428 METDI5124 Methylobacterium extorquens DM4 putative Undecaprenyl-phosphate galactosephosphotransferase YP_003070551.1 5046699 R 661410 CDS YP_003070552.1 254563457 8194429 complement(5048283..5049230) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 11752432, 12954627, 16366586; Product type e : enzyme; GDP-mannose 3,5-epimerase 5049230 gme 8194429 gme Methylobacterium extorquens DM4 GDP-mannose 3,5-epimerase YP_003070552.1 5048283 R 661410 CDS YP_003070553.1 254563458 8195522 complement(5049663..5050442) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative N-acetylmannosaminyltransferase tagA 5050442 8195522 METDI5126 Methylobacterium extorquens DM4 putative N-acetylmannosaminyltransferase tagA YP_003070553.1 5049663 R 661410 CDS YP_003070554.1 254563459 8194430 complement(5050439..5051440) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative sugar nucleotide dehydratase 5051440 8194430 METDI5127 Methylobacterium extorquens DM4 putative sugar nucleotide dehydratase YP_003070554.1 5050439 R 661410 CDS YP_003070555.1 254563460 8194431 5051896..5053263 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative OMA family outer membrane saccharide export protein 5053263 8194431 METDI5128 Methylobacterium extorquens DM4 putative OMA family outer membrane saccharide export protein YP_003070555.1 5051896 D 661410 CDS YP_003070556.1 254563461 8194432 5053316..5054725 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; Mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase 5054725 8194432 METDI5129 Methylobacterium extorquens DM4 Mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase YP_003070556.1 5053316 D 661410 CDS YP_003070557.1 254563462 8194433 5054735..5055124 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5055124 8194433 METDI5130 Methylobacterium extorquens DM4 hypothetical protein YP_003070557.1 5054735 D 661410 CDS YP_003070558.1 254563463 8194434 complement(5055314..5055991) 1 NC_012988.1 Evidence 1c : Function experimentally demonstrated in the studied genus; Product type r : regulator; MxaB 5055991 mxaB 8194434 mxaB Methylobacterium extorquens DM4 MxaB YP_003070558.1 5055314 R 661410 CDS YP_003070559.1 254563464 8195749 complement(5055988..5056587) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; MxaH 5056587 mxaH 8195749 mxaH Methylobacterium extorquens DM4 MxaH YP_003070559.1 5055988 R 661410 CDS YP_003070560.1 254563465 8195755 complement(5056584..5057528) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; MxaE 5057528 mxaE 8195755 mxaE Methylobacterium extorquens DM4 MxaE YP_003070560.1 5056584 R 661410 CDS YP_003070561.1 254563466 8195752 complement(5057553..5058083) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; MxaD protein precursor 5058083 mxaD 8195752 mxaD Methylobacterium extorquens DM4 MxaD protein precursor YP_003070561.1 5057553 R 661410 CDS YP_003070562.1 254563467 8195751 complement(5058083..5059093) 1 NC_012988.1 Evidence 1c : Function experimentally demonstrated in the studied genus; Product type e : enzyme; MxaL protein precursor 5059093 mxaL 8195751 mxaL Methylobacterium extorquens DM4 MxaL protein precursor YP_003070562.1 5058083 R 661410 CDS YP_003070563.1 254563468 8195759 complement(5059090..5059716) 1 NC_012988.1 Evidence 1c : Function experimentally demonstrated in the studied genus; Product type e : enzyme; MxaK protein 5059716 mxaK 8195759 mxaK Methylobacterium extorquens DM4 MxaK protein YP_003070563.1 5059090 R 661410 CDS YP_003070564.1 254563469 8195758 complement(5059716..5060783) 1 NC_012988.1 Evidence 1c : Function experimentally demonstrated in the studied genus; Product type e : enzyme; MxaC protein 5060783 mxaC 8195758 mxaC Methylobacterium extorquens DM4 MxaC protein YP_003070564.1 5059716 R 661410 CDS YP_003070565.1 254563470 8195750 complement(5060788..5061711) 1 NC_012988.1 Evidence 1c : Function experimentally demonstrated in the studied genus; Product type e : enzyme; MxaA protein 5061711 mxaA 8195750 mxaA Methylobacterium extorquens DM4 MxaA protein YP_003070565.1 5060788 R 661410 CDS YP_003070566.1 254563471 8195748 complement(5061717..5062586) 1 NC_012988.1 Evidence 1c : Function experimentally demonstrated in the studied genus; hypothetical protein 5062586 mxaS 8195748 mxaS Methylobacterium extorquens DM4 hypothetical protein YP_003070566.1 5061717 R 661410 CDS YP_003070567.1 254563472 8195761 complement(5062583..5063614) 1 NC_012988.1 Evidence 1c : Function experimentally demonstrated in the studied genus; Protein MxaR (Protein MoxR) 5063614 mxaR 8195761 mxaR Methylobacterium extorquens DM4 Protein MxaR (Protein MoxR) YP_003070567.1 5062583 R 661410 CDS YP_003070568.1 254563473 8195760 complement(5063763..5064053) 1 NC_012988.1 Evidence 1c : Function experimentally demonstrated in the studied genus; PubMedId : 11502173, 2504152, 2842733, 7656012, 7735834; Product type e : enzyme; Methanol dehydrogenase subunit 2 precursor (MDH small beta subunit) 5064053 mxaI 8195760 mxaI Methylobacterium extorquens DM4 Methanol dehydrogenase subunit 2 precursor (MDH small beta subunit) YP_003070568.1 5063763 R 661410 CDS YP_003070569.1 254563474 8195756 complement(5064159..5064752) 1 NC_012988.1 Evidence 1c : Function experimentally demonstrated in the studied genus; Product type e : enzyme; Cytochrome c-L precursor 5064752 mxaG 8195756 mxaG Methylobacterium extorquens DM4 Cytochrome c-L precursor YP_003070569.1 5064159 R 661410 CDS YP_003070570.1 254563475 8195754 complement(5064895..5065797) 1 NC_012988.1 Evidence 1c : Function experimentally demonstrated in the studied genus; PubMedId : 2116368; MxaJ 5065797 mxaJ 8195754 mxaJ Methylobacterium extorquens DM4 MxaJ YP_003070570.1 5064895 R 661410 CDS YP_003070571.1 254563476 8195757 complement(5066061..5067905) 1 NC_012988.1 Evidence 1c : Function experimentally demonstrated in the studied genus; PubMedId : 2504152; Product type e : enzyme; Methanol dehydrogenase subunit 1 precursor (MDH large alpha subunit) (MEDH) 5067905 mxaF 8195757 mxaF Methylobacterium extorquens DM4 Methanol dehydrogenase subunit 1 precursor (MDH large alpha subunit) (MEDH) YP_003070571.1 5066061 R 661410 CDS YP_003070572.1 254563477 8195753 5068312..5069217 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5069217 mxaW 8195753 mxaW Methylobacterium extorquens DM4 hypothetical protein YP_003070572.1 5068312 D 661410 CDS YP_003070573.1 254563478 8195762 5069367..5069564 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5069564 8195762 METDI5147 Methylobacterium extorquens DM4 hypothetical protein YP_003070573.1 5069367 D 661410 CDS YP_003070574.1 254563479 8194435 complement(5069596..5070330) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5070330 8194435 METDI5148 Methylobacterium extorquens DM4 hypothetical protein YP_003070574.1 5069596 R 661410 CDS YP_003070575.1 254563480 8194436 5070676..5071575 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 9495022; Product type pe : putative enzyme; putative metallo-hydrolase/oxidoreductase, beta-lactamase domain protein 5071575 8194436 METDI5149 Methylobacterium extorquens DM4 putative metallo-hydrolase/oxidoreductase, beta-lactamase domain protein YP_003070575.1 5070676 D 661410 CDS YP_003070576.1 254563481 8194437 5071587..5072114 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5072114 8194437 METDI5150 Methylobacterium extorquens DM4 hypothetical protein YP_003070576.1 5071587 D 661410 CDS YP_003070577.1 254563482 8194438 5072111..5072290 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 5072290 8194438 METDI5151 Methylobacterium extorquens DM4 hypothetical protein YP_003070577.1 5072111 D 661410 CDS YP_003070578.1 254563483 8194439 5072508..5073893 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 9495022; Product type pe : putative enzyme; putative glmU-like gene; bifunctional: N-acetyl glucosamine-1-phosphate uridyltransferase (N-terminal); glucosamine-1-phosphate acetyl transferase (C-terminal) 5073893 8194439 METDI5152 Methylobacterium extorquens DM4 putative glmU-like gene; bifunctional: N-acetyl glucosamine-1-phosphate uridyltransferase (N-terminal); glucosamine-1-phosphate acetyl transferase (C-terminal) YP_003070578.1 5072508 D 661410 CDS YP_003070579.1 254563484 8194440 5074078..5075904 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 10091662, 3134953, 8805567, 9739095; Product type e : enzyme; L-glutamine:D-fructose-6-phosphate aminotransferase 5075904 glmS 8194440 glmS Methylobacterium extorquens DM4 L-glutamine:D-fructose-6-phosphate aminotransferase YP_003070579.1 5074078 D 661410 CDS YP_003070580.1 254563485 8195495 complement(5075966..5076400) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 16926146; hypothetical protein 5076400 8195495 METDI5154 Methylobacterium extorquens DM4 hypothetical protein YP_003070580.1 5075966 R 661410 CDS YP_003070581.1 254563486 8194441 5076582..5077427 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 6129240; hypothetical protein 5077427 8194441 METDI5155 Methylobacterium extorquens DM4 hypothetical protein YP_003070581.1 5076582 D 661410 CDS YP_003070582.1 254563487 8194442 complement(5077450..5077776) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 5077776 8194442 METDI5156 Methylobacterium extorquens DM4 hypothetical protein YP_003070582.1 5077450 R 661410 CDS YP_003070583.1 254563488 8194443 complement(5078132..5080321) 1 NC_012988.1 catalyzes branch migration in Holliday junction intermediates; ATP-dependent DNA helicase RecG 5080321 recG 8194443 recG Methylobacterium extorquens DM4 ATP-dependent DNA helicase RecG YP_003070583.1 5078132 R 661410 CDS YP_003070584.1 254563489 8195970 5080513..5080809 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 15593094; hypothetical protein 5080809 8195970 METDI5158 Methylobacterium extorquens DM4 hypothetical protein YP_003070584.1 5080513 D 661410 CDS YP_003070585.1 254563490 8194444 5081023..5084613 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 8465200; Product type pe : putative enzyme; transcription repair coupling protein, ATP-dependent helicase 5084613 mfd 8194444 mfd Methylobacterium extorquens DM4 transcription repair coupling protein, ATP-dependent helicase YP_003070585.1 5081023 D 661410 CDS YP_003070586.1 254563491 8195692 5084990..5085199 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type r : regulator; DNA-binding transcriptional repressor 5085199 cspE 8195692 cspE Methylobacterium extorquens DM4 DNA-binding transcriptional repressor YP_003070586.1 5084990 D 661410 CDS YP_003070587.1 254563492 8195225 5085302..5085670 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5085670 8195225 METDI5161 Methylobacterium extorquens DM4 hypothetical protein YP_003070587.1 5085302 D 661410 CDS YP_003070588.1 254563493 8194445 5085849..5086046 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 5086046 8194445 METDI5162 Methylobacterium extorquens DM4 hypothetical protein YP_003070588.1 5085849 D 661410 CDS YP_003070589.1 254563494 8194446 complement(5086113..5086454) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 5086454 8194446 METDI5164 Methylobacterium extorquens DM4 hypothetical protein YP_003070589.1 5086113 R 661410 CDS YP_003070590.1 254563495 8194447 complement(5086712..5088016) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 5088016 8194447 METDI5165 Methylobacterium extorquens DM4 hypothetical protein YP_003070590.1 5086712 R 661410 CDS YP_003070591.1 254563496 8194448 5088356..5089663 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type prc : putative receptor; integral membrane sensor signal transduction histidine kinase 5089663 8194448 METDI5166 Methylobacterium extorquens DM4 integral membrane sensor signal transduction histidine kinase YP_003070591.1 5088356 D 661410 CDS YP_003070592.1 254563497 8194449 5089865..5090227 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative response regulator; CheY-like protein 5090227 8194449 METDI5167 Methylobacterium extorquens DM4 putative response regulator; CheY-like protein YP_003070592.1 5089865 D 661410 CDS YP_003070593.1 254563498 8194450 complement(5090241..5090537) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type cp : cell process; putative Plasmid stabilisation system protein 5090537 8194450 METDI5168 Methylobacterium extorquens DM4 putative Plasmid stabilisation system protein YP_003070593.1 5090241 R 661410 CDS YP_003070594.1 254563499 8194451 complement(5090516..5090752) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 5090752 8194451 METDI5169 Methylobacterium extorquens DM4 hypothetical protein YP_003070594.1 5090516 R 661410 CDS YP_003070595.1 254563500 8194452 complement(5090787..5092424) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative AMP-dependent synthetase/acyl-CoA ligase 5092424 8194452 METDI5170 Methylobacterium extorquens DM4 putative AMP-dependent synthetase/acyl-CoA ligase YP_003070595.1 5090787 R 661410 CDS YP_003070596.1 254563501 8194453 complement(5092563..5092757) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 5092757 8194453 METDI5171 Methylobacterium extorquens DM4 hypothetical protein YP_003070596.1 5092563 R 661410 CDS YP_003070597.1 254563502 8194454 5093007..5094815 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative glycosyl transferase, putative membrane protein 5094815 8194454 METDI5172 Methylobacterium extorquens DM4 putative glycosyl transferase, putative membrane protein YP_003070597.1 5093007 D 661410 CDS YP_003070598.1 254563503 8194455 5094812..5095585 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 12459482; Product type e : enzyme; glycosyl transferase 5095585 8194455 METDI5173 Methylobacterium extorquens DM4 glycosyl transferase YP_003070598.1 5094812 D 661410 CDS YP_003070599.1 254563504 8194456 5095590..5095919 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5095919 8194456 METDI5174 Methylobacterium extorquens DM4 hypothetical protein YP_003070599.1 5095590 D 661410 CDS YP_003070600.1 254563505 8194457 5095935..5096402 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5096402 8194457 METDI5175 Methylobacterium extorquens DM4 hypothetical protein YP_003070600.1 5095935 D 661410 CDS YP_003070601.1 254563506 8194458 complement(5096403..5097914) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative flavin-binding monooxygenase 5097914 8194458 METDI5176 Methylobacterium extorquens DM4 putative flavin-binding monooxygenase YP_003070601.1 5096403 R 661410 CDS YP_003070602.1 254563507 8194459 complement(5097911..5098831) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative Acetyl-hydrolase 5098831 8194459 METDI5177 Methylobacterium extorquens DM4 putative Acetyl-hydrolase YP_003070602.1 5097911 R 661410 CDS YP_003070603.1 254563508 8194460 complement(5098828..5099652) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; Short-chain dehydrogenase/reductase SDR ; putative exported protein 5099652 8194460 METDI5178 Methylobacterium extorquens DM4 Short-chain dehydrogenase/reductase SDR ; putative exported protein YP_003070603.1 5098828 R 661410 CDS YP_003070604.1 254563509 8194461 complement(5099660..5101156) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5101156 8194461 METDI5179 Methylobacterium extorquens DM4 hypothetical protein YP_003070604.1 5099660 R 661410 CDS YP_003070605.1 254563510 8194462 5101324..5101503 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5101503 8194462 METDI5180 Methylobacterium extorquens DM4 hypothetical protein YP_003070605.1 5101324 D 661410 CDS YP_003070606.1 254563511 8194463 5101510..5101911 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5101911 8194463 METDI5181 Methylobacterium extorquens DM4 hypothetical protein YP_003070606.1 5101510 D 661410 CDS YP_003070607.1 254563512 8194464 5101928..5102860 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 8867604; Product type pm : putative membrane component; hypothetical protein 5102860 8194464 METDI5182 Methylobacterium extorquens DM4 hypothetical protein YP_003070607.1 5101928 D 661410 CDS YP_003070608.1 254563513 8194465 5103181..5104197 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative transmembrane histidine kinase, putaive HK and ATPase domain but no sensory domain detected 5104197 8194465 METDI5183 Methylobacterium extorquens DM4 putative transmembrane histidine kinase, putaive HK and ATPase domain but no sensory domain detected YP_003070608.1 5103181 D 661410 CDS YP_003070609.1 254563514 8194466 5104571..5105374 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8141782; Product type pe : putative enzyme; putative lipolytic enzyme, putative esterase, G-D-S-L family 5105374 8194466 METDI5184 Methylobacterium extorquens DM4 putative lipolytic enzyme, putative esterase, G-D-S-L family YP_003070609.1 5104571 D 661410 CDS YP_003070610.1 254563515 8194467 5105442..5105834 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5105834 8194467 METDI5185 Methylobacterium extorquens DM4 hypothetical protein YP_003070610.1 5105442 D 661410 CDS YP_003070611.1 254563516 8194468 complement(5105943..5106773) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative metal-dependent hydrolase 5106773 8194468 METDI5186 Methylobacterium extorquens DM4 putative metal-dependent hydrolase YP_003070611.1 5105943 R 661410 CDS YP_003070612.1 254563517 8194469 complement(5106790..5107587) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 9546395; Product type pe : putative enzyme; putative metallo-dependent hydrolase, putative deoxyribonuclease, TatD family 5107587 8194469 METDI5187 Methylobacterium extorquens DM4 putative metallo-dependent hydrolase, putative deoxyribonuclease, TatD family YP_003070612.1 5106790 R 661410 CDS YP_003070613.1 254563518 8194470 complement(5107637..5109205) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 9607323; Product type e : enzyme; methionyl-tRNA synthetase 5109205 metG 8194470 metG Methylobacterium extorquens DM4 methionyl-tRNA synthetase YP_003070613.1 5107637 R 661410 CDS YP_003070614.1 254563519 8195683 complement(5109431..5109646) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 5109646 8195683 METDI5189 Methylobacterium extorquens DM4 hypothetical protein YP_003070614.1 5109431 R 661410 CDS YP_003070615.1 254563520 8194471 5109944..5110144 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 5110144 8194471 METDI5190 Methylobacterium extorquens DM4 hypothetical protein YP_003070615.1 5109944 D 661410 CDS YP_003070616.1 254563521 8194472 complement(5110192..5111274) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; DNA polymerase III, delta prime subunit 5111274 holB 8194472 holB Methylobacterium extorquens DM4 DNA polymerase III, delta prime subunit YP_003070616.1 5110192 R 661410 CDS YP_003070617.1 254563522 8195570 complement(5111264..5111998) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; thymidylate kinase 5111998 tmk 8195570 tmk Methylobacterium extorquens DM4 thymidylate kinase YP_003070617.1 5111264 R 661410 CDS YP_003070618.1 254563523 8196201 complement(5112053..5112832) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type t : transporter; putrescine transporter, membrane component of ABC transporter 5112832 potI 8196201 potI Methylobacterium extorquens DM4 putrescine transporter, membrane component of ABC transporter YP_003070618.1 5112053 R 661410 CDS YP_003070619.1 254563524 8195878 complement(5112829..5113836) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type t : transporter; putrescine transporter, membrane component of ABC transporter 5113836 potH 8195878 potH Methylobacterium extorquens DM4 putrescine transporter, membrane component of ABC transporter YP_003070619.1 5112829 R 661410 CDS YP_003070620.1 254563525 8195877 complement(5113833..5114918) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type t : transporter; putrescine transporter, ATP-binding component of ABC transporter 5114918 potG 8195877 potG Methylobacterium extorquens DM4 putrescine transporter, ATP-binding component of ABC transporter YP_003070620.1 5113833 R 661410 CDS YP_003070621.1 254563526 8195876 complement(5115007..5115711) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10403406, 15066032, 20020724, 4367415, 92232655, 93126385, 93345806; Product type pr : putative regulator; putative DNA-binding transcriptional dual regulator 5115711 8195876 METDI5196 Methylobacterium extorquens DM4 putative DNA-binding transcriptional dual regulator YP_003070621.1 5115007 R 661410 CDS YP_003070622.1 254563527 8194473 complement(5116145..5116393) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 5116393 8194473 METDI5197 Methylobacterium extorquens DM4 hypothetical protein YP_003070622.1 5116145 R 661410 CDS YP_003070623.1 254563528 8194474 5116510..5119236 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5119236 8194474 METDI5198 Methylobacterium extorquens DM4 hypothetical protein YP_003070623.1 5116510 D 661410 CDS YP_003070624.1 254563529 8194475 5119319..5119552 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 5119552 8194475 METDI5199 Methylobacterium extorquens DM4 hypothetical protein YP_003070624.1 5119319 D 661410 CDS YP_003070625.1 254563530 8194476 5119637..5120026 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 5120026 8194476 METDI5200 Methylobacterium extorquens DM4 hypothetical protein YP_003070625.1 5119637 D 661410 CDS YP_003070626.1 254563531 8194477 complement(5120064..5121365) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative transporter, major facilitator superfamily 5121365 8194477 METDI5201 Methylobacterium extorquens DM4 putative transporter, major facilitator superfamily YP_003070626.1 5120064 R 661410 CDS YP_003070627.1 254563532 8194478 complement(5121455..5122630) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 11309139, 8898880; Product type e : enzyme; serine-glyoxylate aminotransferase 5122630 sga 8194478 sga Methylobacterium extorquens DM4 serine-glyoxylate aminotransferase YP_003070627.1 5121455 R 661410 CDS YP_003070628.1 254563533 8196116 5122794..5123573 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10068799, 10930734; Product type pr : putative regulator; putative transcriptional regulator, GntR family 5123573 8196116 METDI5203 Methylobacterium extorquens DM4 putative transcriptional regulator, GntR family YP_003070628.1 5122794 D 661410 CDS YP_003070629.1 254563534 8194479 5123629..5124405 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 10561547; Product type e : enzyme; hydroxypyruvate isomerase 5124405 hyi 8194479 hyi Methylobacterium extorquens DM4 hydroxypyruvate isomerase YP_003070629.1 5123629 D 661410 CDS YP_003070630.1 254563535 8195583 complement(5124521..5125393) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 3082854; Product type pe : putative enzyme; putative glucose dehydrogenase, NAD(P)-binding domain 5125393 8195583 METDI5205 Methylobacterium extorquens DM4 putative glucose dehydrogenase, NAD(P)-binding domain YP_003070630.1 5124521 R 661410 CDS YP_003070631.1 254563536 8194480 complement(5125470..5128442) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative D-lactate dehydrogenase (cytochrome) 5128442 8194480 METDI5206 Methylobacterium extorquens DM4 putative D-lactate dehydrogenase (cytochrome) YP_003070631.1 5125470 R 661410 CDS YP_003070632.1 254563537 8194481 complement(5128625..5129989) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type e : enzyme; PHB depolymerase 5129989 depB 8194481 depB Methylobacterium extorquens DM4 PHB depolymerase YP_003070632.1 5128625 R 661410 CDS YP_003070633.1 254563538 8195290 complement(5130290..5131723) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 10543838, 13680097; Product type e : enzyme; succinate-semialdehyde dehydrogenase I, NADP-dependent (gabD-like) 5131723 8195290 METDI5208 Methylobacterium extorquens DM4 succinate-semialdehyde dehydrogenase I, NADP-dependent (gabD-like) YP_003070633.1 5130290 R 661410 CDS YP_003070634.1 254563539 8194482 complement(5131887..5132927) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 5132927 8194482 METDI5209 Methylobacterium extorquens DM4 hypothetical protein YP_003070634.1 5131887 R 661410 CDS YP_003070635.1 254563540 8194483 complement(5133263..5133442) 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 5133442 8194483 METDI5210 Methylobacterium extorquens DM4 hypothetical protein YP_003070635.1 5133263 R 661410 CDS YP_003070636.1 254563541 8194484 5133763..5135334 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 5135334 8194484 METDI5211 Methylobacterium extorquens DM4 hypothetical protein YP_003070636.1 5133763 D 661410 CDS YP_003070637.1 254563542 8194485 5135331..5136662 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5136662 8194485 METDI5212 Methylobacterium extorquens DM4 hypothetical protein YP_003070637.1 5135331 D 661410 CDS YP_003070638.1 254563543 8196241 complement(5137257..5137562) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor; putative flagellar motor switch protein FliN 5137562 8196241 METDI5213 Methylobacterium extorquens DM4 putative flagellar motor switch protein FliN YP_003070638.1 5137257 R 661410 CDS YP_003070639.1 254563544 8194487 5137705..5138355 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; Lipoyltransferase (Lipoyl-[acyl-carrier protein]-protein-N-lipoyltransferase) (Lipoate-protein ligase B) 5138355 lipB 8194487 lipB Methylobacterium extorquens DM4 Lipoyltransferase (Lipoyl-[acyl-carrier protein]-protein-N-lipoyltransferase) (Lipoate-protein ligase B) YP_003070639.1 5137705 D 661410 CDS YP_003070640.1 254563545 8195637 complement(5138481..5139641) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative glycosyl transferase 5139641 8195637 METDI5215 Methylobacterium extorquens DM4 putative glycosyl transferase YP_003070640.1 5138481 R 661410 CDS YP_003070641.1 254563546 8194488 5139887..5140333 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5140333 8194488 METDI5216 Methylobacterium extorquens DM4 hypothetical protein YP_003070641.1 5139887 D 661410 CDS YP_003070642.1 254563547 8194489 complement(5140352..5142310) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative membrane transport protein 5142310 8194489 METDI5217 Methylobacterium extorquens DM4 putative membrane transport protein YP_003070642.1 5140352 R 661410 CDS YP_003070643.1 254563548 8194490 complement(5142539..5142913) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative response regulator receiver 5142913 8194490 METDI5218 Methylobacterium extorquens DM4 putative response regulator receiver YP_003070643.1 5142539 R 661410 CDS YP_003070644.1 254563549 8194491 5143086..5144447 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5144447 8194491 METDI5219 Methylobacterium extorquens DM4 hypothetical protein YP_003070644.1 5143086 D 661410 CDS YP_003070645.1 254563550 8194492 5144531..5146942 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative hybrid histidine kinase; Domains: two PAS, two PAC, His KinaseA, ATPase and two REC (CheY-like) 5146942 8194492 METDI5220 Methylobacterium extorquens DM4 putative hybrid histidine kinase; Domains: two PAS, two PAC, His KinaseA, ATPase and two REC (CheY-like) YP_003070645.1 5144531 D 661410 CDS YP_003070646.1 254563551 8194493 complement(5147058..5148437) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type r : regulator; Regulatory protein, GntR:Aminotransferase, class I and II 5148437 8194493 METDI5221 Methylobacterium extorquens DM4 Regulatory protein, GntR:Aminotransferase, class I and II YP_003070646.1 5147058 R 661410 CDS YP_003070647.1 254563552 8194494 5148595..5149482 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5149482 8194494 METDI5222 Methylobacterium extorquens DM4 hypothetical protein YP_003070647.1 5148595 D 661410 CDS YP_003070648.1 254563553 8194495 complement(5149495..5150229) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type r : regulator; two-component response regulator 5150229 8194495 METDI5223 Methylobacterium extorquens DM4 two-component response regulator YP_003070648.1 5149495 R 661410 CDS YP_003070649.1 254563554 8194496 complement(5150355..5150885) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative GCN5-related N-acetyltransferase 5150885 8194496 METDI5224 Methylobacterium extorquens DM4 putative GCN5-related N-acetyltransferase YP_003070649.1 5150355 R 661410 CDS YP_003070650.1 254563555 8194497 5151073..5151516 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5151516 8194497 METDI5225 Methylobacterium extorquens DM4 hypothetical protein YP_003070650.1 5151073 D 661410 CDS YP_003070651.1 254563556 8194498 complement(5151588..5153327) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 11283302, 11785976, 15919996; Product type t : transporter; glycolate permease (LctP family) 5153327 glcA 8194498 glcA Methylobacterium extorquens DM4 glycolate permease (LctP family) YP_003070651.1 5151588 R 661410 CDS YP_003070652.1 254563557 8195486 5153700..5154623 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 9989945; Product type e : enzyme; Manganese catalase 5154623 cat 8195486 cat Methylobacterium extorquens DM4 Manganese catalase YP_003070652.1 5153700 D 661410 CDS YP_003070653.1 254563558 8195148 complement(5154687..5155583) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 8917308; Product type e : enzyme; terpenoid synthase, putative phytoene synthase 5155583 8195148 METDI5228 Methylobacterium extorquens DM4 terpenoid synthase, putative phytoene synthase YP_003070653.1 5154687 R 661410 CDS YP_003070654.1 254563559 8194499 complement(5155717..5156112) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5156112 8194499 METDI5229 Methylobacterium extorquens DM4 hypothetical protein YP_003070654.1 5155717 R 661410 CDS YP_003070655.1 254563560 8194500 complement(5156237..5157181) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type t : transporter; hypothetical protein 5157181 8194500 METDI5230 Methylobacterium extorquens DM4 hypothetical protein YP_003070655.1 5156237 R 661410 CDS YP_003070656.1 254563561 8194501 complement(5157281..5158879) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type t : transporter; hypothetical protein 5158879 8194501 METDI5231 Methylobacterium extorquens DM4 hypothetical protein YP_003070656.1 5157281 R 661410 CDS YP_003070657.1 254563562 8194502 complement(5158947..5159279) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 12941162, 9826342; Product type t : transporter; preprotein translocase, auxillary membrane component (General Secretory Pathway), YajC subunit 5159279 yajC 8194502 yajC Methylobacterium extorquens DM4 preprotein translocase, auxillary membrane component (General Secretory Pathway), YajC subunit YP_003070657.1 5158947 R 661410 CDS YP_003070658.1 254563563 8196348 5159765..5160655 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5160655 8196348 METDI5233 Methylobacterium extorquens DM4 hypothetical protein YP_003070658.1 5159765 D 661410 CDS YP_003070659.1 254563564 8194503 complement(5160801..5162168) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; hypothetical protein 5162168 8194503 METDI5234 Methylobacterium extorquens DM4 hypothetical protein YP_003070659.1 5160801 R 661410 CDS YP_003070660.1 254563565 8194504 complement(5162370..5163068) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; L-isoaspartate protein carboxylmethyltransferase type II 5163068 pcm 8194504 pcm Methylobacterium extorquens DM4 L-isoaspartate protein carboxylmethyltransferase type II YP_003070660.1 5162370 R 661410 CDS YP_003070661.1 254563566 8195835 complement(5163093..5163857) 1 NC_012988.1 catalyzes the conversion of a phosphate monoester to an alcohol and a phosphate; stationary phase survival protein SurE 5163857 surE 8195835 surE Methylobacterium extorquens DM4 stationary phase survival protein SurE YP_003070661.1 5163093 R 661410 CDS YP_003070662.1 254563567 8196176 complement(5163857..5165143) 1 NC_012988.1 catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; seryl-tRNA synthetase 5165143 serS 8196176 serS Methylobacterium extorquens DM4 seryl-tRNA synthetase YP_003070662.1 5163857 R 661410 CDS YP_003070663.1 254563568 8196113 5165625..5165714 1 NC_012988.1 Required for coenzyme pyrroloquinoline quinone (PQQ) biosynthesis; probably provides the glutamate and tyrosine residues that are cross-linked and modified to form the coenzyme; coenzyme PQQ synthesis protein PqqA 5165714 pqqA 8196113 pqqA Methylobacterium extorquens DM4 coenzyme PQQ synthesis protein PqqA YP_003070663.1 5165625 D 661410 CDS YP_003070664.1 254563569 8195888 complement(5166023..5166541) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8672816, 9023225, 9501442; Product type pr : putative regulator; putative transcriptional regulator, MarR family 5166541 8195888 METDI5239 Methylobacterium extorquens DM4 putative transcriptional regulator, MarR family YP_003070664.1 5166023 R 661410 CDS YP_003070665.1 254563570 8194505 complement(5166703..5167170) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5167170 8194505 METDI5240 Methylobacterium extorquens DM4 hypothetical protein YP_003070665.1 5166703 R 661410 CDS YP_003070666.1 254563571 8194506 complement(5167167..5168327) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative enoyl-CoA hydratase/isomerase family protein 5168327 8194506 METDI5241 Methylobacterium extorquens DM4 putative enoyl-CoA hydratase/isomerase family protein YP_003070666.1 5167167 R 661410 CDS YP_003070667.1 254563572 8194507 5168985..5170040 1 NC_012988.1 catalyzes the formation of porphobilinogen from 5-aminolevulinate; delta-aminolevulinic acid dehydratase 5170040 hemB 8194507 hemB Methylobacterium extorquens DM4 delta-aminolevulinic acid dehydratase YP_003070667.1 5168985 D 661410 CDS YP_003070668.1 254563573 8195549 5170081..5170482 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 5170482 8195549 METDI5243 Methylobacterium extorquens DM4 hypothetical protein YP_003070668.1 5170081 D 661410 CDS YP_003070669.1 254563574 8194508 5170595..5171089 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 5171089 8194508 METDI5244 Methylobacterium extorquens DM4 hypothetical protein YP_003070669.1 5170595 D 661410 CDS YP_003070670.1 254563575 8194509 5171228..5171974 1 NC_012988.1 Conjugates Arg from its aminoacyl-tRNA to the N-termini of proteins containing an N-terminal aspartate or glutamate; arginyl-tRNA-protein transferase 5171974 ate 8194509 ate Methylobacterium extorquens DM4 arginyl-tRNA-protein transferase YP_003070670.1 5171228 D 661410 CDS YP_003070671.1 254563576 8195112 5172061..5172387 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5172387 8195112 METDI5246 Methylobacterium extorquens DM4 hypothetical protein YP_003070671.1 5172061 D 661410 CDS YP_003070672.1 254563577 8194510 5172387..5172704 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5172704 8194510 METDI5247 Methylobacterium extorquens DM4 hypothetical protein YP_003070672.1 5172387 D 661410 CDS YP_003070673.1 254563578 8194511 complement(5172739..5173302) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 82180540, 91310703, 9600841; Product type e : enzyme; maltose o-acetyltransferase 5173302 maa 8194511 maa Methylobacterium extorquens DM4 maltose o-acetyltransferase YP_003070673.1 5172739 R 661410 CDS YP_003070674.1 254563579 8195658 complement(5173330..5174235) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5174235 8195658 METDI5249 Methylobacterium extorquens DM4 hypothetical protein YP_003070674.1 5173330 R 661410 CDS YP_003070675.1 254563580 8194512 complement(5174341..5175375) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative phage DNA polymerase 5175375 8194512 METDI5250 Methylobacterium extorquens DM4 putative phage DNA polymerase YP_003070675.1 5174341 R 661410 CDS YP_003070676.1 254563581 8194513 5175587..5177260 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 12815589, 8306995, 9294455; Product type e : enzyme; electron transfer flavoprotein ubiquinone oxidoreductase 5177260 etfD 8194513 etfD Methylobacterium extorquens DM4 electron transfer flavoprotein ubiquinone oxidoreductase YP_003070676.1 5175587 D 661410 CDS YP_003070677.1 254563582 8195336 complement(5177353..5178342) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5178342 8195336 METDI5252 Methylobacterium extorquens DM4 hypothetical protein YP_003070677.1 5177353 R 661410 CDS YP_003070678.1 254563583 8194514 complement(5178339..5179223) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; putative RarD-like membrane protein, putative chloramphenicol resistance permease 5179223 8194514 METDI5253 Methylobacterium extorquens DM4 putative RarD-like membrane protein, putative chloramphenicol resistance permease YP_003070678.1 5178339 R 661410 CDS YP_003070679.1 254563584 8194515 complement(5179281..5179568) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 5179568 8194515 METDI5254 Methylobacterium extorquens DM4 hypothetical protein YP_003070679.1 5179281 R 661410 CDS YP_003070680.1 254563585 8194516 5179711..5179875 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 5179875 8194516 METDI5255 Methylobacterium extorquens DM4 hypothetical protein YP_003070680.1 5179711 D 661410 CDS YP_003070681.1 254563586 8194517 5179972..5181159 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 8831789; Product type e : enzyme; cystathionine beta-lyase, PLP-dependent (beta-cystathionase) 5181159 metC 8194517 metC Methylobacterium extorquens DM4 cystathionine beta-lyase, PLP-dependent (beta-cystathionase) YP_003070681.1 5179972 D 661410 CDS YP_003070682.1 254563587 8195681 5181537..5182709 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative zinc-containing alcohol dehydrogenase 5182709 8195681 METDI5257 Methylobacterium extorquens DM4 putative zinc-containing alcohol dehydrogenase YP_003070682.1 5181537 D 661410 CDS YP_003070683.1 254563588 8194518 5182781..5183386 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5183386 8194518 METDI5258 Methylobacterium extorquens DM4 hypothetical protein YP_003070683.1 5182781 D 661410 CDS YP_003070684.1 254563589 8194519 5183408..5184502 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5184502 8194519 METDI5259 Methylobacterium extorquens DM4 hypothetical protein YP_003070684.1 5183408 D 661410 CDS YP_003070685.1 254563590 8194520 complement(5184741..5185337) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative pyridoxamine 5'-phosphate oxidase-related, FMN-binding 5185337 8194520 METDI5260 Methylobacterium extorquens DM4 putative pyridoxamine 5'-phosphate oxidase-related, FMN-binding YP_003070685.1 5184741 R 661410 CDS YP_003070686.1 254563591 8194521 5185745..5189023 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative sensor hybrid histidine kinase with multiple PAS/PAC and response regulator receiver domains 5189023 8194521 METDI5261 Methylobacterium extorquens DM4 putative sensor hybrid histidine kinase with multiple PAS/PAC and response regulator receiver domains YP_003070686.1 5185745 D 661410 CDS YP_003070687.1 254563592 8194522 complement(5189057..5191285) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative glycosyl transferase, family 2 5191285 8194522 METDI5262 Methylobacterium extorquens DM4 putative glycosyl transferase, family 2 YP_003070687.1 5189057 R 661410 CDS YP_003070688.1 254563593 8194523 5192039..5192659 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; L-isoaspartate O-methyltransferase (protein beta-aspartate methyltransferase, protein L-isoaspartyl methyltransferase, L-isoaspartyl protein carboxyl methyltransferase) 5192659 pcm 8194523 pcm Methylobacterium extorquens DM4 L-isoaspartate O-methyltransferase (protein beta-aspartate methyltransferase, protein L-isoaspartyl methyltransferase, L-isoaspartyl protein carboxyl methyltransferase) YP_003070688.1 5192039 D 661410 CDS YP_003070689.1 254563594 8195836 5192890..5193393 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 8808920; Product type f : factor; small heat shock protein 5193393 ibpA 8195836 ibpA Methylobacterium extorquens DM4 small heat shock protein YP_003070689.1 5192890 D 661410 CDS YP_003070690.1 254563595 8195586 5193498..5194007 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 5194007 8195586 METDI5265 Methylobacterium extorquens DM4 hypothetical protein YP_003070690.1 5193498 D 661410 CDS YP_003070691.1 254563596 8194524 complement(5194070..5196058) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 12271122; Product type e : enzyme; DNA mismatch repair protein mutL 5196058 mutL 8194524 mutL Methylobacterium extorquens DM4 DNA mismatch repair protein mutL YP_003070691.1 5194070 R 661410 CDS YP_003070692.1 254563597 8195744 complement(5196275..5197501) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11812788, 2777793, 8759838; Product type pe : putative enzyme; putative Short-chain specific acyl-CoA dehydrogenase 5197501 8195744 METDI5267 Methylobacterium extorquens DM4 putative Short-chain specific acyl-CoA dehydrogenase YP_003070692.1 5196275 R 661410 CDS YP_003070693.1 254563598 8194525 5197641..5199506 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative ATP-binding protein with two ATPase domains, ABC transporter related 5199506 8194525 METDI5268 Methylobacterium extorquens DM4 putative ATP-binding protein with two ATPase domains, ABC transporter related YP_003070693.1 5197641 D 661410 CDS YP_003070694.1 254563599 8194526 5199903..5200934 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; Alpha/beta hydrolase related 5200934 8194526 METDI5269 Methylobacterium extorquens DM4 Alpha/beta hydrolase related YP_003070694.1 5199903 D 661410 CDS YP_003070695.1 254563600 8194527 complement(5200910..5201626) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative deaminase reductase domain-containing protein 5201626 8194527 METDI5270 Methylobacterium extorquens DM4 putative deaminase reductase domain-containing protein YP_003070695.1 5200910 R 661410 CDS YP_003070696.1 254563601 8194528 5201775..5202227 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5202227 8194528 METDI5271 Methylobacterium extorquens DM4 hypothetical protein YP_003070696.1 5201775 D 661410 CDS YP_003070697.1 254563602 8194529 5202297..5202734 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5202734 8194529 METDI5272 Methylobacterium extorquens DM4 hypothetical protein YP_003070697.1 5202297 D 661410 CDS YP_003070698.1 254563603 8194530 5203164..5204762 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative ABC transporter protein, periplasmic substrate-binding component (tat pathway signal) 5204762 8194530 METDI5273 Methylobacterium extorquens DM4 putative ABC transporter protein, periplasmic substrate-binding component (tat pathway signal) YP_003070698.1 5203164 D 661410 CDS YP_003070699.1 254563604 8194531 5204759..5205682 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 2187863, 86111606, 93106975; Product type t : transporter; oligopeptide transporter subunit ; membrane component of ABC superfamily 5205682 oppB 8194531 oppB Methylobacterium extorquens DM4 oligopeptide transporter subunit ; membrane component of ABC superfamily YP_003070699.1 5204759 D 661410 CDS YP_003070700.1 254563605 8195811 5205679..5206770 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type c : carrier; ABC transporter, permease protein, putative oligopeptide transport system permease protein, oppC-related 5206770 8195811 METDI5275 Methylobacterium extorquens DM4 ABC transporter, permease protein, putative oligopeptide transport system permease protein, oppC-related YP_003070700.1 5205679 D 661410 CDS YP_003070701.1 254563606 8194532 complement(5206778..5207068) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 5207068 8194532 METDI5276 Methylobacterium extorquens DM4 hypothetical protein YP_003070701.1 5206778 R 661410 CDS YP_003070702.1 254563607 8194533 5207200..5208678 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type t : transporter; Major facilitator superfamily MFS-1, putative sugar transport protein 5208678 8194533 METDI5277 Methylobacterium extorquens DM4 Major facilitator superfamily MFS-1, putative sugar transport protein YP_003070702.1 5207200 D 661410 CDS YP_003070703.1 254563608 8194534 complement(5208941..5209531) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 5209531 8194534 METDI5278 Methylobacterium extorquens DM4 hypothetical protein YP_003070703.1 5208941 R 661410 CDS YP_003070704.1 254563609 8194535 complement(5209671..5210369) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5210369 8194535 METDI5279 Methylobacterium extorquens DM4 hypothetical protein YP_003070704.1 5209671 R 661410 CDS YP_003070705.1 254563610 8194536 complement(5210601..5211539) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type r : regulator; Transcriptional regulator, LysR family 5211539 8194536 METDI5280 Methylobacterium extorquens DM4 Transcriptional regulator, LysR family YP_003070705.1 5210601 R 661410 CDS YP_003070706.1 254563611 8194537 5211740..5212339 1 NC_012988.1 stationary phase protein that binds TrpR repressor; TrpR binding protein WrbA 5212339 wrbA 8194537 wrbA Methylobacterium extorquens DM4 TrpR binding protein WrbA YP_003070706.1 5211740 D 661410 CDS YP_003070707.1 254563612 8196335 complement(5212401..5214545) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type e : enzyme; putative thiol:disulfide interchange protein precursor 5214545 8196335 METDI5282 Methylobacterium extorquens DM4 putative thiol:disulfide interchange protein precursor YP_003070707.1 5212401 R 661410 CDS YP_003070708.1 254563613 8194538 complement(5214738..5217524) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 12887908, 1938937, 88032849, 89112166, 92291095, 99410452; Product type e : enzyme; DNA mismatch repair protein mutS 5217524 mutS 8194538 mutS Methylobacterium extorquens DM4 DNA mismatch repair protein mutS YP_003070708.1 5214738 R 661410 CDS YP_003070709.1 254563614 8195746 complement(5217691..5218008) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 5218008 8195746 METDI5284 Methylobacterium extorquens DM4 hypothetical protein YP_003070709.1 5217691 R 661410 CDS YP_003070710.1 254563615 8194539 5218191..5220680 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 95206938; Product type e : enzyme; helicase, ATP-dependent 5220680 hrpB 8194539 hrpB Methylobacterium extorquens DM4 helicase, ATP-dependent YP_003070710.1 5218191 D 661410 CDS YP_003070711.1 254563616 8195577 complement(5220637..5221350) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 5221350 8195577 METDI5286 Methylobacterium extorquens DM4 hypothetical protein YP_003070711.1 5220637 R 661410 CDS YP_003070712.1 254563617 8194540 5221551..5221922 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 5221922 8194540 METDI5287 Methylobacterium extorquens DM4 hypothetical protein YP_003070712.1 5221551 D 661410 CDS YP_003070713.1 254563618 8194541 complement(5221935..5222330) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10882093, 16926146; Product type pe : putative enzyme; putative lactoylglutathione lyase 5222330 8194541 METDI5288 Methylobacterium extorquens DM4 putative lactoylglutathione lyase YP_003070713.1 5221935 R 661410 CDS YP_003070714.1 254563619 8194542 5222452..5223549 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 10744667, 7715441; Product type e : enzyme; ptyrosine recombinase xerC, integrase/recombinase Ripx (xerC) 5223549 xerC 8194542 xerC Methylobacterium extorquens DM4 ptyrosine recombinase xerC, integrase/recombinase Ripx (xerC) YP_003070714.1 5222452 D 661410 CDS YP_003070715.1 254563620 8196337 5223649..5223783 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 5223783 8196337 METDI5290 Methylobacterium extorquens DM4 hypothetical protein YP_003070715.1 5223649 D 661410 CDS YP_003070716.1 254563621 8194543 complement(5223866..5224462) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative phosphoglycerate mutase 5224462 8194543 METDI5291 Methylobacterium extorquens DM4 putative phosphoglycerate mutase YP_003070716.1 5223866 R 661410 CDS YP_003070717.1 254563622 8194544 5224638..5225642 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5225642 8194544 METDI5292 Methylobacterium extorquens DM4 hypothetical protein YP_003070717.1 5224638 D 661410 CDS YP_003070718.1 254563623 8194545 5225731..5226888 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5226888 8194545 METDI5293 Methylobacterium extorquens DM4 hypothetical protein YP_003070718.1 5225731 D 661410 CDS YP_003070719.1 254563624 8194546 5226890..5227579 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; MOSC domain protein, YiiM-like protein 5227579 8194546 METDI5294 Methylobacterium extorquens DM4 MOSC domain protein, YiiM-like protein YP_003070719.1 5226890 D 661410 CDS YP_003070720.1 254563625 8194547 complement(5227583..5228410) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 10398587, 2687243; Product type e : enzyme; Enoyl-[acyl-carrier-protein] reductase (NADH) 5228410 fabI 8194547 fabI Methylobacterium extorquens DM4 Enoyl-[acyl-carrier-protein] reductase (NADH) YP_003070720.1 5227583 R 661410 CDS YP_003070721.1 254563626 8195349 complement(5228648..5229580) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 10092456, 9276481, 9349721; Product type f : factor; Chaperone DnaJ domain protein, putative heat shock protein 5229580 8195349 METDI5296 Methylobacterium extorquens DM4 Chaperone DnaJ domain protein, putative heat shock protein YP_003070721.1 5228648 R 661410 CDS YP_003070722.1 254563627 8194548 complement(5229732..5230274) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 5230274 8194548 METDI5297 Methylobacterium extorquens DM4 hypothetical protein YP_003070722.1 5229732 R 661410 CDS YP_003070723.1 254563628 8194549 5230427..5231005 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 12878029, 14515321; Product type e : enzyme; pyridoxine 5'-phosphate oxidase 5231005 pdxH 8194549 pdxH Methylobacterium extorquens DM4 pyridoxine 5'-phosphate oxidase YP_003070723.1 5230427 D 661410 CDS YP_003070724.1 254563629 8195841 complement(5231040..5231423) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative response regulator receiver (CheY-like protein) 5231423 8195841 METDI5299 Methylobacterium extorquens DM4 putative response regulator receiver (CheY-like protein) YP_003070724.1 5231040 R 661410 CDS YP_003070725.1 254563630 8194550 5231734..5232459 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 3313281; Product type e : enzyme; Short-chain dehydrogenase/reductase SDR 5232459 fixR1 8194550 fixR1 Methylobacterium extorquens DM4 Short-chain dehydrogenase/reductase SDR YP_003070725.1 5231734 D 661410 CDS YP_003070726.1 254563631 8195385 5232452..5233603 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 15602564, 9352903; hypothetical protein 5233603 8195385 METDI5301 Methylobacterium extorquens DM4 hypothetical protein YP_003070726.1 5232452 D 661410 CDS YP_003070727.1 254563632 8194551 5233600..5234085 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative GDP-mannose mannosyl hydrolase (nudD) 5234085 8194551 METDI5302 Methylobacterium extorquens DM4 putative GDP-mannose mannosyl hydrolase (nudD) YP_003070727.1 5233600 D 661410 CDS YP_003070728.1 254563633 8194552 5234082..5234537 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5234537 8194552 METDI5303 Methylobacterium extorquens DM4 hypothetical protein YP_003070728.1 5234082 D 661410 CDS YP_003070729.1 254563634 8194553 5234877..5235131 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5235131 8194553 METDI5304 Methylobacterium extorquens DM4 hypothetical protein YP_003070729.1 5234877 D 661410 CDS YP_003070730.1 254563635 8194554 complement(5235330..5236901) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 5236901 8194554 METDI5305 Methylobacterium extorquens DM4 hypothetical protein YP_003070730.1 5235330 R 661410 CDS YP_003070731.1 254563636 8194555 complement(5237203..5238540) 1 NC_012988.1 Catalyzes the reversible hydrolysis of the amide bond within dihydroorotate. This metabolic intermediate is required for the biosynthesis of pyrimidine nucleotides; dihydroorotase 5238540 pyrC 8194555 pyrC Methylobacterium extorquens DM4 dihydroorotase YP_003070731.1 5237203 R 661410 CDS YP_003070732.1 254563637 8195948 5238642..5239496 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; Glycine cleavage T protein (aminomethyl transferase) 5239496 8195948 METDI5307 Methylobacterium extorquens DM4 Glycine cleavage T protein (aminomethyl transferase) YP_003070732.1 5238642 D 661410 CDS YP_003070733.1 254563638 8194556 5239493..5240122 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 3536912; Product type e : enzyme; 3-methyl-adenine DNA glycosylase I 5240122 tag 8194556 tag Methylobacterium extorquens DM4 3-methyl-adenine DNA glycosylase I YP_003070733.1 5239493 D 661410 CDS YP_003070734.1 254563639 8196178 5240119..5240745 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 8282711, 8759915, 9210332; Product type e : enzyme; Metal-dependent phosphohydrolase 5240745 8196178 METDI5309 Methylobacterium extorquens DM4 Metal-dependent phosphohydrolase YP_003070734.1 5240119 D 661410 CDS YP_003070735.1 254563640 8194557 5240760..5241272 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5241272 8194557 METDI5310 Methylobacterium extorquens DM4 hypothetical protein YP_003070735.1 5240760 D 661410 CDS YP_003070736.1 254563641 8194558 5241372..5241638 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; exodeoxyribonuclease VII small subunit (exonuclease VII small subunit) 5241638 xseB 8194558 xseB Methylobacterium extorquens DM4 exodeoxyribonuclease VII small subunit (exonuclease VII small subunit) YP_003070736.1 5241372 D 661410 CDS YP_003070737.1 254563642 8196344 5241728..5243704 1 NC_012988.1 catalyzes the formation of 1-deoxy-D-xylulose 5-phosphate from pyruvate and D-glyceraldehyde 3-phosphate; 1-deoxy-D-xylulose-5-phosphate synthase 5243704 dxs 8196344 dxs Methylobacterium extorquens DM4 1-deoxy-D-xylulose-5-phosphate synthase YP_003070737.1 5241728 D 661410 CDS YP_003070738.1 254563643 8195322 complement(5243750..5244370) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 11136448, 2345128, 7589534, 7786035, 7929223, 8626323, 9003353, 9405149; Product type e : enzyme; Superoxide dismutase [Cu-Zn] precursor 5244370 sod 8195322 sod Methylobacterium extorquens DM4 Superoxide dismutase [Cu-Zn] precursor YP_003070738.1 5243750 R 661410 CDS YP_003070739.1 254563644 8196119 5244715..5245467 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 9611795; Product type e : enzyme; hemolysin 5245467 tly 8196119 tly Methylobacterium extorquens DM4 hemolysin YP_003070739.1 5244715 D 661410 CDS YP_003070740.1 254563645 8196200 5245479..5246762 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; 23S rRNA (Uracil-5-)-methyltransferase 5246762 rumA 8196200 rumA Methylobacterium extorquens DM4 23S rRNA (Uracil-5-)-methyltransferase YP_003070740.1 5245479 D 661410 CDS YP_003070741.1 254563646 8196091 complement(5246836..5248080) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 5248080 8196091 METDI5316 Methylobacterium extorquens DM4 hypothetical protein YP_003070741.1 5246836 R 661410 CDS YP_003070742.1 254563647 8194559 5248396..5249391 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 12003941, 8636017; hypothetical protein 5249391 8194559 METDI5317 Methylobacterium extorquens DM4 hypothetical protein YP_003070742.1 5248396 D 661410 CDS YP_003070743.1 254563648 8194560 complement(5249404..5250135) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5250135 8194560 METDI5318 Methylobacterium extorquens DM4 hypothetical protein YP_003070743.1 5249404 R 661410 CDS YP_003070744.1 254563649 8194561 5250417..5251637 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5251637 8194561 METDI5319 Methylobacterium extorquens DM4 hypothetical protein YP_003070744.1 5250417 D 661410 CDS YP_003070745.1 254563650 8194562 5251634..5252791 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 7730270; Product type e : enzyme; amidohydrolase 5252791 8194562 METDI5320 Methylobacterium extorquens DM4 amidohydrolase YP_003070745.1 5251634 D 661410 CDS YP_003070746.1 254563651 8194563 5253042..5254127 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type r : regulator; fused DNA-binding transcriptional dual regulator ; O6-methylguanine-DNA methyltransferase 5254127 ada 8194563 ada Methylobacterium extorquens DM4 fused DNA-binding transcriptional dual regulator ; O6-methylguanine-DNA methyltransferase YP_003070746.1 5253042 D 661410 CDS YP_003070747.1 254563652 8195062 complement(5254132..5255154) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12215815, 2678100, 8829543; Product type pt : putative transporter; putative cation transport protein 5255154 8195062 METDI5322 Methylobacterium extorquens DM4 putative cation transport protein YP_003070747.1 5254132 R 661410 CDS YP_003070748.1 254563653 8194564 5255276..5255704 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative histidine triad family protein, putative nucleoside phosphate hydrolase 5255704 8194564 METDI5323 Methylobacterium extorquens DM4 putative histidine triad family protein, putative nucleoside phosphate hydrolase YP_003070748.1 5255276 D 661410 CDS YP_003070749.1 254563654 8194565 complement(5255760..5256206) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5256206 8194565 METDI5324 Methylobacterium extorquens DM4 hypothetical protein YP_003070749.1 5255760 R 661410 CDS YP_003070750.1 254563655 8194566 complement(5256288..5256536) 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 5256536 8194566 METDI5325 Methylobacterium extorquens DM4 hypothetical protein YP_003070750.1 5256288 R 661410 CDS YP_003070751.1 254563656 8194567 complement(5256650..5256835) 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 5256835 8194567 METDI5326 Methylobacterium extorquens DM4 hypothetical protein YP_003070751.1 5256650 R 661410 CDS YP_003070752.1 254563657 8194568 complement(5256802..5258685) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative glucoamylase or glycosyl hydrolase protein 5258685 8194568 METDI5327 Methylobacterium extorquens DM4 putative glucoamylase or glycosyl hydrolase protein YP_003070752.1 5256802 R 661410 CDS YP_003070753.1 254563658 8194569 complement(5258777..5259055) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 5259055 8194569 METDI5328 Methylobacterium extorquens DM4 hypothetical protein YP_003070753.1 5258777 R 661410 CDS YP_003070754.1 254563659 8194570 complement(5259118..5260275) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative N-acetylglucosamine-6-phosphate deacetylase (nagA-like) 5260275 8194570 METDI5329 Methylobacterium extorquens DM4 putative N-acetylglucosamine-6-phosphate deacetylase (nagA-like) YP_003070754.1 5259118 R 661410 CDS YP_003070755.1 254563660 8194571 complement(5260382..5261392) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative Glucosamine-fructose-6-phosphate aminotransferase (gmlS-like) 5261392 8194571 METDI5330 Methylobacterium extorquens DM4 putative Glucosamine-fructose-6-phosphate aminotransferase (gmlS-like) YP_003070755.1 5260382 R 661410 CDS YP_003070756.1 254563661 8194572 complement(5261389..5262276) 1 NC_012988.1 catalyzes the cleavage of the lactyl ether moiety of N-acetylmuramic acid-6-phosphate (MurNAc-6-P) to form N-acetylglucosamine-6-phosphate (GlcNAc-6-P) and lactate; involved in MurNAc dissimilation pathway; N-acetylmuramic acid-6-phosphate etherase 5262276 murQ 8194572 murQ Methylobacterium extorquens DM4 N-acetylmuramic acid-6-phosphate etherase YP_003070756.1 5261389 R 661410 CDS YP_003070757.1 254563662 8194573 5262530..5263357 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative endonuclease/exonuclease/phosphatase 5263357 8194573 METDI5332 Methylobacterium extorquens DM4 putative endonuclease/exonuclease/phosphatase YP_003070757.1 5262530 D 661410 CDS YP_003070758.1 254563663 8194574 5263436..5264503 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative periplasmic L-asparaginase (ansB) 5264503 8194574 METDI5333 Methylobacterium extorquens DM4 putative periplasmic L-asparaginase (ansB) YP_003070758.1 5263436 D 661410 CDS YP_003070759.1 254563664 8194575 complement(5264620..5266167) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative phospholipase D/transphosphatidylase 5266167 8194575 METDI5334 Methylobacterium extorquens DM4 putative phospholipase D/transphosphatidylase YP_003070759.1 5264620 R 661410 CDS YP_003070760.1 254563665 8194576 complement(5266226..5266924) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5266924 8194576 METDI5335 Methylobacterium extorquens DM4 hypothetical protein YP_003070760.1 5266226 R 661410 CDS YP_003070761.1 254563666 8194577 complement(5267072..5267482) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 5267482 8194577 METDI5336 Methylobacterium extorquens DM4 hypothetical protein YP_003070761.1 5267072 R 661410 CDS YP_003070762.1 254563667 8194578 complement(5267698..5268423) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10622737; Product type pm : putative membrane component; putative surfeit locus 1 family protein (surf1-like) 5268423 8194578 METDI5337 Methylobacterium extorquens DM4 putative surfeit locus 1 family protein (surf1-like) YP_003070762.1 5267698 R 661410 CDS YP_003070763.1 254563668 8194579 complement(5268485..5268865) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 11017202; Product type e : enzyme; cytochrome o ubiquinol oxidase, subunit IV 5268865 cyoD 8194579 cyoD Methylobacterium extorquens DM4 cytochrome o ubiquinol oxidase, subunit IV YP_003070763.1 5268485 R 661410 CDS YP_003070764.1 254563669 8195246 complement(5268862..5269509) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 11017202; Product type e : enzyme; cytochrome o ubiquinol oxidase, subunit III 5269509 cyoC 8195246 cyoC Methylobacterium extorquens DM4 cytochrome o ubiquinol oxidase, subunit III YP_003070764.1 5268862 R 661410 CDS YP_003070765.1 254563670 8195245 complement(5269518..5271521) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 11017202; Product type e : enzyme; cytochrome o ubiquinol oxidase, subunit I 5271521 cyoB 8195245 cyoB Methylobacterium extorquens DM4 cytochrome o ubiquinol oxidase, subunit I YP_003070765.1 5269518 R 661410 CDS YP_003070766.1 254563671 8195244 complement(5271561..5272685) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 11017202; Product type e : enzyme; cytochrome o ubiquinol oxidase subunit II 5272685 cyoA 8195244 cyoA Methylobacterium extorquens DM4 cytochrome o ubiquinol oxidase subunit II YP_003070766.1 5271561 R 661410 CDS YP_003070767.1 254563672 8195243 complement(5272919..5274253) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type t : transporter; MFS transporter membrane protein 5274253 8195243 METDI5342 Methylobacterium extorquens DM4 MFS transporter membrane protein YP_003070767.1 5272919 R 661410 CDS YP_003070768.1 254563673 8194580 complement(5274545..5277607) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type t : transporter; RND efflux transporter, AcrB/AcrD/AcrF family 5277607 8194580 METDI5343 Methylobacterium extorquens DM4 RND efflux transporter, AcrB/AcrD/AcrF family YP_003070768.1 5274545 R 661410 CDS YP_003070769.1 254563674 8194581 complement(5277664..5278827) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type t : transporter; RND efflux transporter, membrane fusion protein subunit 5278827 8194581 METDI5344 Methylobacterium extorquens DM4 RND efflux transporter, membrane fusion protein subunit YP_003070769.1 5277664 R 661410 CDS YP_003070770.1 254563675 8194582 complement(5278824..5279987) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type t : transporter; RND efflux transporter, membrane fusion protein subunit precursor 5279987 8194582 METDI5345 Methylobacterium extorquens DM4 RND efflux transporter, membrane fusion protein subunit precursor YP_003070770.1 5278824 R 661410 CDS YP_003070771.1 254563676 8194583 5280207..5280767 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcriptional regulator, TetR family 5280767 8194583 METDI5346 Methylobacterium extorquens DM4 putative transcriptional regulator, TetR family YP_003070771.1 5280207 D 661410 CDS YP_003070772.1 254563677 8194584 complement(5281087..5281791) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11158353; Product type pr : putative regulator; putative two-component transcriptional regulator, LuxR family 5281791 8194584 METDI5347 Methylobacterium extorquens DM4 putative two-component transcriptional regulator, LuxR family YP_003070772.1 5281087 R 661410 CDS YP_003070773.1 254563678 8194585 complement(5281799..5283013) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 5283013 8194585 METDI5348 Methylobacterium extorquens DM4 hypothetical protein YP_003070773.1 5281799 R 661410 CDS YP_003070774.1 254563679 8194586 5283316..5283741 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; transposase of ISMex15, IS5 family (ORF 1) 5283741 8194586 METDI5349 Methylobacterium extorquens DM4 transposase of ISMex15, IS5 family (ORF 1) YP_003070774.1 5283316 D 661410 CDS YP_003070775.1 254563680 8194587 5283753..5284070 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; transposase of ISMex15, IS5 family (ORF 2) 5284070 8194587 METDI5350 Methylobacterium extorquens DM4 transposase of ISMex15, IS5 family (ORF 2) YP_003070775.1 5283753 D 661410 CDS YP_003070776.1 254563681 8194588 5284541..5285191 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative two-component transcriptional regulator, LuxR family 5285191 8194588 METDI5351 Methylobacterium extorquens DM4 putative two-component transcriptional regulator, LuxR family YP_003070776.1 5284541 D 661410 CDS YP_003070777.1 254563682 8194589 5285385..5286146 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative two-component transcriptional regulator, LuxR family 5286146 8194589 METDI5352 Methylobacterium extorquens DM4 putative two-component transcriptional regulator, LuxR family YP_003070777.1 5285385 D 661410 CDS YP_003070778.1 254563683 8194590 5286241..5287059 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10482500; Product type pe : putative enzyme; putative glycosyl transferase 5287059 8194590 METDI5353 Methylobacterium extorquens DM4 putative glycosyl transferase YP_003070778.1 5286241 D 661410 CDS YP_003070779.1 254563684 8194591 5287229..5288413 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 5288413 8194591 METDI5354 Methylobacterium extorquens DM4 hypothetical protein YP_003070779.1 5287229 D 661410 CDS YP_003070780.1 254563685 8196255 5288827..5290635 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative phage integrase 5290635 8196255 METDI5356 Methylobacterium extorquens DM4 putative phage integrase YP_003070780.1 5288827 D 661410 CDS YP_003070781.1 254563686 8194593 complement(5290662..5290877) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcriptional regulator 5290877 8194593 METDI5357 Methylobacterium extorquens DM4 putative transcriptional regulator YP_003070781.1 5290662 R 661410 CDS YP_003070782.1 254563687 8194594 5291030..5292280 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative metallo-beta-lactamase family protein 5292280 8194594 METDI5358 Methylobacterium extorquens DM4 putative metallo-beta-lactamase family protein YP_003070782.1 5291030 D 661410 CDS YP_003070783.1 254563688 8194595 5292277..5293356 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5293356 8194595 METDI5359 Methylobacterium extorquens DM4 hypothetical protein YP_003070783.1 5292277 D 661410 CDS YP_003070784.1 254563689 8194596 5293665..5294495 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 5294495 8194596 METDI5360 Methylobacterium extorquens DM4 hypothetical protein YP_003070784.1 5293665 D 661410 CDS YP_003070785.1 254563690 8194597 5294518..5294952 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 5294952 8194597 METDI5361 Methylobacterium extorquens DM4 hypothetical protein YP_003070785.1 5294518 D 661410 CDS YP_003070786.1 254563691 8194598 5294883..5295674 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 5295674 8194598 METDI5362 Methylobacterium extorquens DM4 hypothetical protein YP_003070786.1 5294883 D 661410 CDS YP_003070787.1 254563692 8194599 5295872..5296150 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 5296150 8194599 METDI5363 Methylobacterium extorquens DM4 hypothetical protein YP_003070787.1 5295872 D 661410 CDS YP_003070788.1 254563693 8194600 complement(5296258..5300343) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5300343 8194600 METDI5364 Methylobacterium extorquens DM4 hypothetical protein YP_003070788.1 5296258 R 661410 CDS YP_003070789.1 254563694 8194602 5301299..5302534 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 5302534 8194602 METDI5367 Methylobacterium extorquens DM4 hypothetical protein YP_003070789.1 5301299 D 661410 CDS YP_003070790.1 254563695 8194603 5302432..5302635 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 5302635 8194603 METDI5368 Methylobacterium extorquens DM4 hypothetical protein YP_003070790.1 5302432 D 661410 CDS YP_003070791.1 254563696 8194604 5302712..5304574 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5304574 8194604 METDI5369 Methylobacterium extorquens DM4 hypothetical protein YP_003070791.1 5302712 D 661410 CDS YP_003070792.1 254563697 8194605 5304697..5304930 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 5304930 8194605 METDI5370 Methylobacterium extorquens DM4 hypothetical protein YP_003070792.1 5304697 D 661410 CDS YP_003070793.1 254563698 8194606 5305232..5305738 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 5305738 8194606 METDI5371 Methylobacterium extorquens DM4 hypothetical protein YP_003070793.1 5305232 D 661410 CDS YP_003070794.1 254563699 8194607 5305822..5311638 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative DNA helicase related protein 5311638 8194607 METDI5372 Methylobacterium extorquens DM4 putative DNA helicase related protein YP_003070794.1 5305822 D 661410 CDS YP_003070795.1 254563700 8194608 complement(5311813..5312088) 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 5312088 8194608 METDI5373 Methylobacterium extorquens DM4 hypothetical protein YP_003070795.1 5311813 R 661410 CDS YP_003070796.1 254563701 8194609 complement(5312388..5313146) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 5313146 8194609 METDI5374 Methylobacterium extorquens DM4 hypothetical protein YP_003070796.1 5312388 R 661410 CDS YP_003070797.1 254563702 8194610 5314116..5315195 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor; putative ardC antirestriction protein 5315195 8194610 METDI5375 Methylobacterium extorquens DM4 putative ardC antirestriction protein YP_003070797.1 5314116 D 661410 CDS YP_003070798.1 254563703 8194611 5314817..5315770 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 5315770 8194611 METDI5376 Methylobacterium extorquens DM4 hypothetical protein YP_003070798.1 5314817 D 661410 CDS YP_003070799.1 254563704 8194612 complement(5315866..5318295) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 5318295 8194612 METDI5377 Methylobacterium extorquens DM4 hypothetical protein YP_003070799.1 5315866 R 661410 CDS YP_003070800.1 254563705 8194613 complement(5318292..5320712) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 5320712 8194613 METDI5378 Methylobacterium extorquens DM4 hypothetical protein YP_003070800.1 5318292 R 661410 CDS YP_003070801.1 254563706 8194614 complement(5320612..5321904) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 5321904 8194614 METDI5379 Methylobacterium extorquens DM4 hypothetical protein YP_003070801.1 5320612 R 661410 CDS YP_003070802.1 254563707 8194615 complement(5322230..5322481) 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 5322481 8194615 METDI5380 Methylobacterium extorquens DM4 hypothetical protein YP_003070802.1 5322230 R 661410 CDS YP_003070803.1 254563708 8194616 5322539..5322742 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 5322742 8194616 METDI5381 Methylobacterium extorquens DM4 hypothetical protein YP_003070803.1 5322539 D 661410 CDS YP_003070804.1 254563709 8194617 5322960..5323463 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 5323463 8194617 METDI5382 Methylobacterium extorquens DM4 hypothetical protein YP_003070804.1 5322960 D 661410 CDS YP_003070805.1 254563710 8194618 5323497..5325260 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative protease/peptidase 5325260 8194618 METDI5383 Methylobacterium extorquens DM4 putative protease/peptidase YP_003070805.1 5323497 D 661410 CDS YP_003070806.1 254563711 8194619 5325273..5326628 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 5326628 8194619 METDI5384 Methylobacterium extorquens DM4 hypothetical protein YP_003070806.1 5325273 D 661410 CDS YP_003070807.1 254563712 8194620 5326679..5329789 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type f : factor; virulence factor SrfB 5329789 srfB 8194620 srfB Methylobacterium extorquens DM4 virulence factor SrfB YP_003070807.1 5326679 D 661410 CDS YP_003070808.1 254563713 8196145 5329786..5332443 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type f : factor; virulence factor SrfC 5332443 srfC 8196145 srfC Methylobacterium extorquens DM4 virulence factor SrfC YP_003070808.1 5329786 D 661410 CDS YP_003070809.1 254563714 8196146 5332406..5333551 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5333551 8196146 METDI5387 Methylobacterium extorquens DM4 hypothetical protein YP_003070809.1 5332406 D 661410 CDS YP_003070810.1 254563715 8194621 5333620..5335422 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 5335422 8194621 METDI5388 Methylobacterium extorquens DM4 hypothetical protein YP_003070810.1 5333620 D 661410 CDS YP_003070811.1 254563716 8194622 5335460..5336044 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5336044 8194622 METDI5389 Methylobacterium extorquens DM4 hypothetical protein YP_003070811.1 5335460 D 661410 CDS YP_003070812.1 254563717 8194623 5336259..5336993 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 5336993 8194623 METDI5390 Methylobacterium extorquens DM4 hypothetical protein YP_003070812.1 5336259 D 661410 CDS YP_003070813.1 254563718 8194624 5337583..5338593 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 9025293; Product type e : enzyme; fermentative D-lactate dehydrogenase, NAD-dependent 5338593 ldhA 8194624 ldhA Methylobacterium extorquens DM4 fermentative D-lactate dehydrogenase, NAD-dependent YP_003070813.1 5337583 D 661410 CDS YP_003070814.1 254563719 8195626 complement(5338622..5339575) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcriptional regulator, LysR family 5339575 8195626 METDI5392 Methylobacterium extorquens DM4 putative transcriptional regulator, LysR family YP_003070814.1 5338622 R 661410 CDS YP_003070815.1 254563720 8194625 5339750..5339998 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 5339998 8194625 METDI5393 Methylobacterium extorquens DM4 hypothetical protein YP_003070815.1 5339750 D 661410 CDS YP_003070816.1 254563721 8194626 5340065..5340805 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5340805 8194626 METDI5394 Methylobacterium extorquens DM4 hypothetical protein YP_003070816.1 5340065 D 661410 CDS YP_003070817.1 254563722 8194627 complement(5340875..5341774) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 5341774 8194627 METDI5395 Methylobacterium extorquens DM4 hypothetical protein YP_003070817.1 5340875 R 661410 CDS YP_003070818.1 254563723 8194628 complement(5341771..5342745) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11532010; Product type pe : putative enzyme; putative glycerate dehydrogenase (gyaR-like) 5342745 8194628 METDI5396 Methylobacterium extorquens DM4 putative glycerate dehydrogenase (gyaR-like) YP_003070818.1 5341771 R 661410 CDS YP_003070819.1 254563724 8194629 complement(5342712..5342999) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 5342999 8194629 METDI5397 Methylobacterium extorquens DM4 hypothetical protein YP_003070819.1 5342712 R 661410 CDS YP_003070820.1 254563725 8194630 5343020..5344429 1 NC_012988.1 dehydratase component, catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; isopropylmalate isomerase large subunit 5344429 leuC 8194630 leuC Methylobacterium extorquens DM4 isopropylmalate isomerase large subunit YP_003070820.1 5343020 D 661410 CDS YP_003070821.1 254563726 8196240 5344836..5345024 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 5345024 8196240 METDI5399 Methylobacterium extorquens DM4 hypothetical protein YP_003070821.1 5344836 D 661410 CDS YP_003070822.1 254563727 8194631 5345178..5345456 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 5345456 8194631 METDI5400 Methylobacterium extorquens DM4 hypothetical protein YP_003070822.1 5345178 D 661410 CDS YP_003070823.1 254563728 8194632 complement(5345523..5346122) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcriptional regulator, TetR family 5346122 8194632 METDI5401 Methylobacterium extorquens DM4 putative transcriptional regulator, TetR family YP_003070823.1 5345523 R 661410 CDS YP_003070824.1 254563729 8194633 5346217..5347482 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 9044268; Product type t : transporter; RND efflux transporter, membrane fusion protein subunit 5347482 8194633 METDI5402 Methylobacterium extorquens DM4 RND efflux transporter, membrane fusion protein subunit YP_003070824.1 5346217 D 661410 CDS YP_003070825.1 254563730 8194634 5347582..5350776 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 9044268; Product type t : transporter; RND efflux transporter, hydrophobe/amphiphile efflux-1 (HAE1) family 5350776 8194634 METDI5403 Methylobacterium extorquens DM4 RND efflux transporter, hydrophobe/amphiphile efflux-1 (HAE1) family YP_003070825.1 5347582 D 661410 CDS YP_003070826.1 254563731 8194635 5351235..5351837 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type r : regulator; transcriptional regulator, TetR family 5351837 8194635 METDI5404 Methylobacterium extorquens DM4 transcriptional regulator, TetR family YP_003070826.1 5351235 D 661410 CDS YP_003070827.1 254563732 8194636 5352014..5352697 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5352697 8194636 METDI5405 Methylobacterium extorquens DM4 hypothetical protein YP_003070827.1 5352014 D 661410 CDS YP_003070828.1 254563733 8194637 complement(5352627..5352872) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 5352872 8194637 METDI5406 Methylobacterium extorquens DM4 hypothetical protein YP_003070828.1 5352627 R 661410 CDS YP_003070829.1 254563734 8194639 complement(5353375..5354061) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative Zn-dependent protease 5354061 8194639 METDI5408 Methylobacterium extorquens DM4 putative Zn-dependent protease YP_003070829.1 5353375 R 661410 CDS YP_003070830.1 254563735 8194640 complement(5354046..5354159) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 5354159 8194640 METDI5409 Methylobacterium extorquens DM4 hypothetical protein YP_003070830.1 5354046 R 661410 CDS YP_003070831.1 254563736 8194641 complement(5354284..5355900) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative cyclic nucleotide-regulated FAD-dependent pyridine nucleotide-disulphide oxidoreductase 5355900 8194641 METDI5410 Methylobacterium extorquens DM4 putative cyclic nucleotide-regulated FAD-dependent pyridine nucleotide-disulphide oxidoreductase YP_003070831.1 5354284 R 661410 CDS YP_003070832.1 254563737 8194642 complement(5356196..5357092) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 5357092 8194642 METDI5411 Methylobacterium extorquens DM4 hypothetical protein YP_003070832.1 5356196 R 661410 CDS YP_003070833.1 254563738 8194643 5357256..5357834 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5357834 8194643 METDI5412 Methylobacterium extorquens DM4 hypothetical protein YP_003070833.1 5357256 D 661410 CDS YP_003070834.1 254563739 8194644 complement(5358253..5359515) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative NAD binding site:Amine oxidase 5359515 8194644 METDI5413 Methylobacterium extorquens DM4 putative NAD binding site:Amine oxidase YP_003070834.1 5358253 R 661410 CDS YP_003070835.1 254563740 8194645 5359719..5360549 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 12244065; Product type e : enzyme; isonitrile hydratase precursor, ThiJ/PfpI family protein 5360549 inh 8194645 inh Methylobacterium extorquens DM4 isonitrile hydratase precursor, ThiJ/PfpI family protein YP_003070835.1 5359719 D 661410 CDS YP_003070836.1 254563741 8195602 complement(5360996..5361424) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 16926146; hypothetical protein 5361424 8195602 METDI5415 Methylobacterium extorquens DM4 hypothetical protein YP_003070836.1 5360996 R 661410 CDS YP_003070837.1 254563742 8194646 5361636..5362661 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative ABC transporter, periplasmic protein; putative sulfonate-binding protein precursor 5362661 8194646 METDI5417 Methylobacterium extorquens DM4 putative ABC transporter, periplasmic protein; putative sulfonate-binding protein precursor YP_003070837.1 5361636 D 661410 CDS YP_003070838.1 254563743 8194647 5362681..5363433 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative aliphatic sulfonates transport permease protein ssuC 5363433 8194647 METDI5418 Methylobacterium extorquens DM4 putative aliphatic sulfonates transport permease protein ssuC YP_003070838.1 5362681 D 661410 CDS YP_003070839.1 254563744 8194648 5363430..5364191 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 20245523, 3549459, 7984428, 99410391, 99436146; Product type t : transporter; alkanesulfonate transporter subunit ; ATP-binding component of ABC superfamily 5364191 ssuB 8194648 ssuB Methylobacterium extorquens DM4 alkanesulfonate transporter subunit ; ATP-binding component of ABC superfamily YP_003070839.1 5363430 D 661410 CDS YP_003070840.1 254563745 8196157 5364304..5364738 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5364738 8196157 METDI5420 Methylobacterium extorquens DM4 hypothetical protein YP_003070840.1 5364304 D 661410 CDS YP_003070841.1 254563746 8194649 5364878..5365069 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 5365069 8194649 METDI5421 Methylobacterium extorquens DM4 hypothetical protein YP_003070841.1 5364878 D 661410 CDS YP_003070842.1 254563747 8194650 complement(5365372..5366991) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 7737996, 8016068, 8016077, 8575429, 94286525, 94286535; Product type f : factor; peptide chain release factor RF-3; GTP-binding factor 5366991 prfC 8194650 prfC Methylobacterium extorquens DM4 peptide chain release factor RF-3; GTP-binding factor YP_003070842.1 5365372 R 661410 CDS YP_003070843.1 254563748 8195896 complement(5367098..5367841) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; Short-chain dehydrogenase/reductase SDR 5367841 8195896 METDI5423 Methylobacterium extorquens DM4 Short-chain dehydrogenase/reductase SDR YP_003070843.1 5367098 R 661410 CDS YP_003070844.1 254563749 8196256 complement(5368468..5368956) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5368956 8196256 METDI5424 Methylobacterium extorquens DM4 hypothetical protein YP_003070844.1 5368468 R 661410 CDS YP_003070845.1 254563750 8194652 5369324..5369800 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 5369800 8194652 METDI5425 Methylobacterium extorquens DM4 hypothetical protein YP_003070845.1 5369324 D 661410 CDS YP_003070846.1 254563751 8194653 complement(5370320..5371510) 1 NC_012988.1 EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu; elongation factor Tu 5371510 tuf 8194653 tuf Methylobacterium extorquens DM4 elongation factor Tu YP_003070846.1 5370320 R 661410 CDS YP_003070847.1 254563752 8196289 complement(5371633..5371908) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor; putative ribosome-associated RNA-binding protein S4 paralog, putative heat-shock protein 5371908 8196289 METDI5428 Methylobacterium extorquens DM4 putative ribosome-associated RNA-binding protein S4 paralog, putative heat-shock protein YP_003070847.1 5371633 R 661410 CDS YP_003070848.1 254563753 8194654 complement(5371985..5375392) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 8550440; hypothetical protein 5375392 8194654 METDI5429 Methylobacterium extorquens DM4 hypothetical protein YP_003070848.1 5371985 R 661410 CDS YP_003070849.1 254563754 8194655 complement(5375582..5375926) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 5375926 8194655 METDI5430 Methylobacterium extorquens DM4 hypothetical protein YP_003070849.1 5375582 R 661410 CDS YP_003070850.1 254563755 8194656 complement(5376143..5377039) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5377039 8194656 METDI5431 Methylobacterium extorquens DM4 hypothetical protein YP_003070850.1 5376143 R 661410 CDS YP_003070851.1 254563756 8194657 complement(5377223..5378224) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 7592399; Product type pe : putative enzyme; putative Glucokinase (Glucose kinase) 5378224 8194657 METDI5432 Methylobacterium extorquens DM4 putative Glucokinase (Glucose kinase) YP_003070851.1 5377223 R 661410 CDS YP_003070852.1 254563757 8194658 complement(5378315..5379070) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative trehalose-6-phosphate phosphatase (otsB) 5379070 8194658 METDI5433 Methylobacterium extorquens DM4 putative trehalose-6-phosphate phosphatase (otsB) YP_003070852.1 5378315 R 661410 CDS YP_003070853.1 254563758 8194659 5379157..5379651 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5379651 8194659 METDI5434 Methylobacterium extorquens DM4 hypothetical protein YP_003070853.1 5379157 D 661410 CDS YP_003070854.1 254563759 8194660 5379724..5380941 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; Beta-lactamase 5380941 8194660 METDI5435 Methylobacterium extorquens DM4 Beta-lactamase YP_003070854.1 5379724 D 661410 CDS YP_003070855.1 254563760 8194661 5381158..5383089 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type t : transporter; transporter, betaine/carnitine/choline transporter (BCCT) family 5383089 8194661 METDI5436 Methylobacterium extorquens DM4 transporter, betaine/carnitine/choline transporter (BCCT) family YP_003070855.1 5381158 D 661410 CDS YP_003070856.1 254563761 8194662 5383581..5384054 1 NC_012988.1 Evidence 1c : Function experimentally demonstrated in the studied genus; PubMedId : 12730156; Product type e : enzyme; NAD-dependent formate dehydrogenase, Molybdenum containing, gamma subunit 5384054 fdh2C 8194662 fdh2C Methylobacterium extorquens DM4 NAD-dependent formate dehydrogenase, Molybdenum containing, gamma subunit YP_003070856.1 5383581 D 661410 CDS YP_003070857.1 254563762 8195364 5384051..5385610 1 NC_012988.1 Evidence 1c : Function experimentally demonstrated in the studied genus; PubMedId : 12730156; Product type e : enzyme; NAD-dependent formate dehydrogenase, Molybdenum containing, beta subunit 5385610 fdh2B 8195364 fdh2B Methylobacterium extorquens DM4 NAD-dependent formate dehydrogenase, Molybdenum containing, beta subunit YP_003070857.1 5384051 D 661410 CDS YP_003070858.1 254563763 8195363 5385623..5388475 1 NC_012988.1 Evidence 1c : Function experimentally demonstrated in the studied genus; PubMedId : 12730156; Product type e : enzyme; NAD-dependent formate dehydrogenase, molybdenum containing, alpha subunit 5388475 fdh2A 8195363 fdh2A Methylobacterium extorquens DM4 NAD-dependent formate dehydrogenase, molybdenum containing, alpha subunit YP_003070858.1 5385623 D 661410 CDS YP_003070859.1 254563764 8195362 5388682..5388972 1 NC_012988.1 Evidence 1c : Function experimentally demonstrated in the studied genus; PubMedId : 12730156; Product type e : enzyme; NAD-linked formate dehydrogenase, Molybdenum containing, delta subunit 5388972 fdh2D 8195362 fdh2D Methylobacterium extorquens DM4 NAD-linked formate dehydrogenase, Molybdenum containing, delta subunit YP_003070859.1 5388682 D 661410 CDS YP_003070860.1 254563765 8195365 5389064..5389999 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type r : regulator; transcriptional regulator, LysR family 5389999 8195365 METDI5441 Methylobacterium extorquens DM4 transcriptional regulator, LysR family YP_003070860.1 5389064 D 661410 CDS YP_003070861.1 254563766 8194663 complement(5390071..5390517) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 5390517 8194663 METDI5442 Methylobacterium extorquens DM4 hypothetical protein YP_003070861.1 5390071 R 661410 CDS YP_003070862.1 254563767 8194664 complement(5390585..5391619) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type cp : cell process; small GTP-binding protein, putative GTPase 5391619 8194664 METDI5443 Methylobacterium extorquens DM4 small GTP-binding protein, putative GTPase YP_003070862.1 5390585 R 661410 CDS YP_003070863.1 254563768 8194665 complement(5391656..5392135) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 5392135 8194665 METDI5444 Methylobacterium extorquens DM4 hypothetical protein YP_003070863.1 5391656 R 661410 CDS YP_003070864.1 254563769 8194666 complement(5392132..5392731) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative acetyltransferase, putative N-acetylase of ribosomal proteins 5392731 8194666 METDI5445 Methylobacterium extorquens DM4 putative acetyltransferase, putative N-acetylase of ribosomal proteins YP_003070864.1 5392132 R 661410 CDS YP_003070865.1 254563770 8194667 complement(5392920..5393186) 1 NC_012988.1 involved in the peptidyltransferase reaction during translation; 50S ribosomal protein L27 5393186 rpmA 8194667 rpmA Methylobacterium extorquens DM4 50S ribosomal protein L27 YP_003070865.1 5392920 R 661410 CDS YP_003070866.1 254563771 8196035 complement(5393235..5393627) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type s : structure; 50S ribosomal protein L21 5393627 rplU 8196035 rplU Methylobacterium extorquens DM4 50S ribosomal protein L21 YP_003070866.1 5393235 R 661410 CDS YP_003070867.1 254563772 8196030 complement(5393823..5395385) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative enzyme with nucleoside triphosphate hydrolase domain 5395385 yjgR 8196030 yjgR Methylobacterium extorquens DM4 putative enzyme with nucleoside triphosphate hydrolase domain YP_003070867.1 5393823 R 661410 CDS YP_003070868.1 254563773 8196371 5395540..5395926 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5395926 8196371 METDI5450 Methylobacterium extorquens DM4 hypothetical protein YP_003070868.1 5395540 D 661410 CDS YP_003070869.1 254563774 8194668 5396079..5397137 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5397137 8194668 METDI5451 Methylobacterium extorquens DM4 hypothetical protein YP_003070869.1 5396079 D 661410 CDS YP_003070870.1 254563775 8194669 5397115..5398383 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type t : transporter; permease of major facilitator transporter (tat pathway signal) 5398383 8194669 METDI5452 Methylobacterium extorquens DM4 permease of major facilitator transporter (tat pathway signal) YP_003070870.1 5397115 D 661410 CDS YP_003070871.1 254563776 8194670 5398485..5398613 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 5398613 8194670 METDI5453 Methylobacterium extorquens DM4 hypothetical protein YP_003070871.1 5398485 D 661410 CDS YP_003070872.1 254563777 8194671 5398967..5399215 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 5399215 8194671 METDI5454 Methylobacterium extorquens DM4 hypothetical protein YP_003070872.1 5398967 D 661410 CDS YP_003070873.1 254563778 8194672 complement(5399234..5400352) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative patatin-like phospholipase 5400352 8194672 METDI5455 Methylobacterium extorquens DM4 putative patatin-like phospholipase YP_003070873.1 5399234 R 661410 CDS YP_003070874.1 254563779 8194673 5400885..5401436 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5401436 8194673 METDI5456 Methylobacterium extorquens DM4 hypothetical protein YP_003070874.1 5400885 D 661410 CDS YP_003070875.1 254563780 8194674 5401641..5401856 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 5401856 8194674 METDI5457 Methylobacterium extorquens DM4 hypothetical protein YP_003070875.1 5401641 D 661410 CDS YP_003070876.1 254563781 8194675 5401853..5402371 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5402371 8194675 METDI5458 Methylobacterium extorquens DM4 hypothetical protein YP_003070876.1 5401853 D 661410 CDS YP_003070877.1 254563782 8194676 5402448..5403347 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative diacylglycerol kinase related protein 5403347 8194676 METDI5459 Methylobacterium extorquens DM4 putative diacylglycerol kinase related protein YP_003070877.1 5402448 D 661410 CDS YP_003070878.1 254563783 8194677 5403344..5404228 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative metallophosphatase/metallophosphoesterase 5404228 8194677 METDI5460 Methylobacterium extorquens DM4 putative metallophosphatase/metallophosphoesterase YP_003070878.1 5403344 D 661410 CDS YP_003070879.1 254563784 8194678 complement(5404254..5405714) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative sodium:solute symporter 5405714 8194678 METDI5461 Methylobacterium extorquens DM4 putative sodium:solute symporter YP_003070879.1 5404254 R 661410 CDS YP_003070880.1 254563785 8194679 complement(5405711..5405914) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pf : putative factor; hypothetical protein 5405914 8194679 METDI5462 Methylobacterium extorquens DM4 hypothetical protein YP_003070880.1 5405711 R 661410 CDS YP_003070881.1 254563786 8194680 complement(5406093..5408204) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type prc : putative receptor; putative PAS sensor hybrid histidine kinase 5408204 8194680 METDI5463 Methylobacterium extorquens DM4 putative PAS sensor hybrid histidine kinase YP_003070881.1 5406093 R 661410 CDS YP_003070882.1 254563787 8194681 complement(5408401..5408850) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5408850 8194681 METDI5464 Methylobacterium extorquens DM4 hypothetical protein YP_003070882.1 5408401 R 661410 CDS YP_003070883.1 254563788 8194682 complement(5408912..5409658) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative Nucleotidyl transferase 5409658 8194682 METDI5465 Methylobacterium extorquens DM4 putative Nucleotidyl transferase YP_003070883.1 5408912 R 661410 CDS YP_003070884.1 254563789 8194683 complement(5409692..5411320) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5411320 8194683 METDI5466 Methylobacterium extorquens DM4 hypothetical protein YP_003070884.1 5409692 R 661410 CDS YP_003070885.1 254563790 8194684 complement(5411578..5414121) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative histidine kinase, putative HK, ATPase and Sensor Domain 5414121 8194684 METDI5467 Methylobacterium extorquens DM4 putative histidine kinase, putative HK, ATPase and Sensor Domain YP_003070885.1 5411578 R 661410 CDS YP_003070886.1 254563791 8194685 complement(5414611..5416017) 1 NC_012988.1 catalyzes the formation of L-homocysteine from S-adenosyl-L-homocysteine; S-adenosyl-L-homocysteine hydrolase 5416017 ahcY 8194685 ahcY Methylobacterium extorquens DM4 S-adenosyl-L-homocysteine hydrolase YP_003070886.1 5414611 R 661410 CDS YP_003070887.1 254563792 8195065 complement(5416187..5417875) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 7934817; Product type e : enzyme; putative acetyl-coenzyme A synthetase (acsA-like) 5417875 8195065 METDI5469 Methylobacterium extorquens DM4 putative acetyl-coenzyme A synthetase (acsA-like) YP_003070887.1 5416187 R 661410 CDS YP_003070888.1 254563793 8194686 complement(5417953..5418564) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pe : putative enzyme; putative oxidoreductase protein 5418564 8194686 METDI5470 Methylobacterium extorquens DM4 putative oxidoreductase protein YP_003070888.1 5417953 R 661410 CDS YP_003070889.1 254563794 8194687 5418716..5419621 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 10727085; Product type e : enzyme; enoyl-CoA hydratase 5419621 8194687 METDI5471 Methylobacterium extorquens DM4 enoyl-CoA hydratase YP_003070889.1 5418716 D 661410 CDS YP_003070890.1 254563795 8194688 5419728..5420507 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5420507 8194688 METDI5472 Methylobacterium extorquens DM4 hypothetical protein YP_003070890.1 5419728 D 661410 CDS YP_003070891.1 254563796 8194689 complement(5420398..5421834) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 12382061, 9370333; Product type e : enzyme; Cardiolipin synthase (cls-like) 5421834 cls 8194689 cls Methylobacterium extorquens DM4 Cardiolipin synthase (cls-like) YP_003070891.1 5420398 R 661410 CDS YP_003070892.1 254563797 8195175 5422059..5425202 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5425202 8195175 METDI5474 Methylobacterium extorquens DM4 hypothetical protein YP_003070892.1 5422059 D 661410 CDS YP_003070893.1 254563798 8194690 5425199..5428642 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative helicase-exonuclease type V protein family 5428642 8194690 METDI5475 Methylobacterium extorquens DM4 putative helicase-exonuclease type V protein family YP_003070893.1 5425199 D 661410 CDS YP_003070894.1 254563799 8194691 complement(5428738..5430024) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 16864586; Product type e : enzyme; PQQ-dependent aldose sugar dehydrogenase precursor (asd), signal peptide 5430024 yliI 8194691 yliI Methylobacterium extorquens DM4 PQQ-dependent aldose sugar dehydrogenase precursor (asd), signal peptide YP_003070894.1 5428738 R 661410 CDS YP_003070895.1 254563800 8196374 5430077..5430412 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 5430412 8196374 METDI5477 Methylobacterium extorquens DM4 hypothetical protein YP_003070895.1 5430077 D 661410 CDS YP_003070896.1 254563801 8194692 5430400..5430720 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 16926146, 7021558, 90202710, 99175138; Product type e : enzyme; thioredoxin 5430720 trx 8194692 trx Methylobacterium extorquens DM4 thioredoxin YP_003070896.1 5430400 D 661410 CDS YP_003070897.1 254563802 8196284 complement(5430878..5431768) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; putative 31 kDa outer-membrane immunogenic protein precursor (omp31) 5431768 8196284 METDI5479 Methylobacterium extorquens DM4 putative 31 kDa outer-membrane immunogenic protein precursor (omp31) YP_003070897.1 5430878 R 661410 CDS YP_003070898.1 254563803 8194693 complement(5432157..5433482) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type e : enzyme; bifunctional folylpolyglutamate synthase and dihydrofolate synthase 5433482 folC 8194693 folC Methylobacterium extorquens DM4 bifunctional folylpolyglutamate synthase and dihydrofolate synthase YP_003070898.1 5432157 R 661410 CDS YP_003070899.1 254563804 8195436 complement(5433515..5434438) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 1355086, 16325142; Product type e : enzyme; acetyl-CoA carboxylase, carboxyltransferase subunit beta 5434438 accD 8195436 accD Methylobacterium extorquens DM4 acetyl-CoA carboxylase, carboxyltransferase subunit beta YP_003070899.1 5433515 R 661410 CDS YP_003070900.1 254563805 8195047 complement(5434549..5435391) 1 NC_012988.1 catalyzes the formation of indole and glyceraldehyde 3-phosphate from indoleglycerol phosphate in tryptophan biosynthesis; tryptophan synthase subunit alpha 5435391 trpA 8195047 trpA Methylobacterium extorquens DM4 tryptophan synthase subunit alpha YP_003070900.1 5434549 R 661410 CDS YP_003070901.1 254563806 8196272 complement(5435563..5436522) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative nucleotide pyrophosphatase 5436522 8196272 METDI5483 Methylobacterium extorquens DM4 putative nucleotide pyrophosphatase YP_003070901.1 5435563 R 661410 CDS YP_003070902.1 254563807 8194694 complement(5436533..5436949) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative histidine triad (HIT) protein 5436949 8194694 METDI5484 Methylobacterium extorquens DM4 putative histidine triad (HIT) protein YP_003070902.1 5436533 R 661410 CDS YP_003070903.1 254563808 8194695 5437072..5438190 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative metal dependent phosphohydrolase with a response regulator receiver domain; HD-GYP domain protein 5438190 8194695 METDI5485 Methylobacterium extorquens DM4 putative metal dependent phosphohydrolase with a response regulator receiver domain; HD-GYP domain protein YP_003070903.1 5437072 D 661410 CDS YP_003070904.1 254563809 8194696 5438530..5440236 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative ATP-independent RNA helicase, DEAD/DEAH-box family protein 5440236 8194696 METDI5486 Methylobacterium extorquens DM4 putative ATP-independent RNA helicase, DEAD/DEAH-box family protein YP_003070904.1 5438530 D 661410 CDS YP_003070905.1 254563810 8194697 complement(5440333..5441199) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 5441199 8194697 METDI5487 Methylobacterium extorquens DM4 hypothetical protein YP_003070905.1 5440333 R 661410 CDS YP_003070906.1 254563811 8194698 5441666..5443153 1 NC_012988.1 Evidence 1c : Function experimentally demonstrated in the studied genus; Product type r : regulator; integral membrane sensor signal transduction histidine kinase 5443153 mxcQ 8194698 mxcQ Methylobacterium extorquens DM4 integral membrane sensor signal transduction histidine kinase YP_003070906.1 5441666 D 661410 CDS YP_003070907.1 254563812 8195766 5443164..5443853 1 NC_012988.1 Evidence 1c : Function experimentally demonstrated in the studied genus; Product type r : regulator; two component transcriptional regulator 5443853 mxcE 8195766 mxcE Methylobacterium extorquens DM4 two component transcriptional regulator YP_003070907.1 5443164 D 661410 CDS YP_003070908.1 254563813 8195765 5443881..5444564 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcriptional activator (TenA family) 5444564 8195765 METDI5490 Methylobacterium extorquens DM4 putative transcriptional activator (TenA family) YP_003070908.1 5443881 D 661410 CDS YP_003070909.1 254563814 8194699 5444729..5446219 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative amino acid transporter 5446219 8194699 METDI5491 Methylobacterium extorquens DM4 putative amino acid transporter YP_003070909.1 5444729 D 661410 CDS YP_003070910.1 254563815 8194700 complement(5446420..5447325) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative hydrolase of beta-lactamase superfamily 5447325 8194700 METDI5492 Methylobacterium extorquens DM4 putative hydrolase of beta-lactamase superfamily YP_003070910.1 5446420 R 661410 CDS YP_003070911.1 254563816 8194701 complement(5447517..5448662) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5448662 8194701 METDI5493 Methylobacterium extorquens DM4 hypothetical protein YP_003070911.1 5447517 R 661410 CDS YP_003070912.1 254563817 8194702 complement(5448830..5451433) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5451433 8194702 METDI5494 Methylobacterium extorquens DM4 hypothetical protein YP_003070912.1 5448830 R 661410 CDS YP_003070913.1 254563818 8194703 5451819..5453810 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 5453810 8194703 METDI5495 Methylobacterium extorquens DM4 hypothetical protein YP_003070913.1 5451819 D 661410 CDS YP_003070914.1 254563819 8194704 5453807..5455036 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 5455036 8194704 METDI5496 Methylobacterium extorquens DM4 hypothetical protein YP_003070914.1 5453807 D 661410 CDS YP_003070915.1 254563820 8194705 5455095..5455916 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; glutamine amidotransferase class II 5455916 8194705 METDI5497 Methylobacterium extorquens DM4 glutamine amidotransferase class II YP_003070915.1 5455095 D 661410 CDS YP_003070916.1 254563821 8194706 5456164..5456898 1 NC_012988.1 Evidence 1c : Function experimentally demonstrated in the studied genus; Product type f : factor; RNA polymerase sigma factor 5456898 ecfG1 8194706 ecfG1 Methylobacterium extorquens DM4 RNA polymerase sigma factor YP_003070916.1 5456164 D 661410 CDS YP_003070917.1 254563822 8195323 complement(5457628..5458161) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type r : regulator; transcriptional regulator (Ros/MucR family) 5458161 8195323 METDI5499 Methylobacterium extorquens DM4 transcriptional regulator (Ros/MucR family) YP_003070917.1 5457628 R 661410 CDS YP_003070918.1 254563823 8194707 complement(5458533..5458931) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 5458931 8194707 METDI5500 Methylobacterium extorquens DM4 hypothetical protein YP_003070918.1 5458533 R 661410 CDS YP_003070919.1 254563824 8194708 5459029..5460342 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5460342 8194708 METDI5501 Methylobacterium extorquens DM4 hypothetical protein YP_003070919.1 5459029 D 661410 CDS YP_003070920.1 254563825 8194709 complement(5460563..5460883) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; ferredoxin 5460883 8194709 METDI5502 Methylobacterium extorquens DM4 ferredoxin YP_003070920.1 5460563 R 661410 CDS YP_003070921.1 254563826 8194710 complement(5461099..5461443) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5461443 8194710 METDI5503 Methylobacterium extorquens DM4 hypothetical protein YP_003070921.1 5461099 R 661410 CDS YP_003070922.1 254563827 8194711 5461804..5470197 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 5470197 8194711 METDI5504 Methylobacterium extorquens DM4 hypothetical protein YP_003070922.1 5461804 D 661410 CDS YP_003070923.1 254563828 8194712 complement(5470353..5470982) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcriptional regulator, XRE family 5470982 8194712 METDI5505 Methylobacterium extorquens DM4 putative transcriptional regulator, XRE family YP_003070923.1 5470353 R 661410 CDS YP_003070924.1 254563829 8194713 complement(5471159..5471965) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; bifunctional: hydroxy-methylpyrimidine kinase (HMP kinase); hydroxy-phosphomethylpyrimidine kinase (HMP-P kinase) 5471965 thiD 8194713 thiD Methylobacterium extorquens DM4 bifunctional: hydroxy-methylpyrimidine kinase (HMP kinase); hydroxy-phosphomethylpyrimidine kinase (HMP-P kinase) YP_003070924.1 5471159 R 661410 CDS YP_003070925.1 254563830 8196186 complement(5472013..5472738) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; thiamine-phosphate pyrophosphorylase (TMP pyrophosphorylase) (TMP-PPase) (thiamine-phosphate synthase) 5472738 thiE 8196186 thiE Methylobacterium extorquens DM4 thiamine-phosphate pyrophosphorylase (TMP pyrophosphorylase) (TMP-PPase) (thiamine-phosphate synthase) YP_003070925.1 5472013 R 661410 CDS YP_003070926.1 254563831 8196188 5472864..5473970 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5473970 8196188 METDI5508 Methylobacterium extorquens DM4 hypothetical protein YP_003070926.1 5472864 D 661410 CDS YP_003070927.1 254563832 8194714 complement(5474036..5474311) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 5474311 8194714 METDI5509 Methylobacterium extorquens DM4 hypothetical protein YP_003070927.1 5474036 R 661410 CDS YP_003070928.1 254563833 8194715 complement(5474628..5475158) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type r : regulator; transcriptional regulator (Ros/MucR family) 5475158 8194715 METDI5511 Methylobacterium extorquens DM4 transcriptional regulator (Ros/MucR family) YP_003070928.1 5474628 R 661410 CDS YP_003070929.1 254563834 8194716 complement(5476094..5477038) 1 NC_012988.1 catalyzes the reduction of N-acetyl-5-glutamyl phosphate to N-acetyl-L-glutamate 5-semialdehyde in arginine biosynthesis; N-acetyl-gamma-glutamyl-phosphate reductase 5477038 argC 8194716 argC Methylobacterium extorquens DM4 N-acetyl-gamma-glutamyl-phosphate reductase YP_003070929.1 5476094 R 661410 CDS YP_003070930.1 254563835 8195084 5477294..5477833 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5477833 8195084 METDI5513 Methylobacterium extorquens DM4 hypothetical protein YP_003070930.1 5477294 D 661410 CDS YP_003070931.1 254563836 8194717 complement(5477886..5478695) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 7860583, 8564363, 8576221, 90148107, 92011425, 9302996, 93368423; Product type t : transporter; molybdate ABC transporter, periplasmic molybdate-binding protein 5478695 modA 8194717 modA Methylobacterium extorquens DM4 molybdate ABC transporter, periplasmic molybdate-binding protein YP_003070931.1 5477886 R 661410 CDS YP_003070932.1 254563837 8195709 complement(5478866..5479036) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 5479036 8195709 METDI5515 Methylobacterium extorquens DM4 hypothetical protein YP_003070932.1 5478866 R 661410 CDS YP_003070933.1 254563838 8194718 complement(5479129..5479329) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 5479329 8194718 METDI5516 Methylobacterium extorquens DM4 hypothetical protein YP_003070933.1 5479129 R 661410 CDS YP_003070934.1 254563839 8194719 5479654..5480571 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 15317787; Product type e : enzyme; Ribosomal protein L11 methyltransferase (L11 Mtase) 5480571 prmA 8194719 prmA Methylobacterium extorquens DM4 Ribosomal protein L11 methyltransferase (L11 Mtase) YP_003070934.1 5479654 D 661410 CDS YP_003070935.1 254563840 8195899 5480743..5482581 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; aminopeptidase 5482581 8195899 METDI5518 Methylobacterium extorquens DM4 aminopeptidase YP_003070935.1 5480743 D 661410 CDS YP_003070936.1 254563841 8194720 5482578..5483057 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 7961734; Product type e : enzyme; phosphotyrosine protein phosphatase 5483057 8194720 METDI5519 Methylobacterium extorquens DM4 phosphotyrosine protein phosphatase YP_003070936.1 5482578 D 661410 CDS YP_003070937.1 254563842 8194721 5483054..5483860 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative phosphotransferase:kinase 5483860 8194721 METDI5520 Methylobacterium extorquens DM4 putative phosphotransferase:kinase YP_003070937.1 5483054 D 661410 CDS YP_003070938.1 254563843 8194722 complement(5484026..5486140) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative ABC transporter, fused permease and ATPase components, putative membrane protein precursor 5486140 8194722 METDI5521 Methylobacterium extorquens DM4 putative ABC transporter, fused permease and ATPase components, putative membrane protein precursor YP_003070938.1 5484026 R 661410 CDS YP_003070939.1 254563844 8194723 complement(5486414..5486743) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5486743 8194723 METDI5523 Methylobacterium extorquens DM4 hypothetical protein YP_003070939.1 5486414 R 661410 CDS YP_003070940.1 254563845 8194724 5487035..5487691 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 5487691 8194724 METDI5524 Methylobacterium extorquens DM4 hypothetical protein YP_003070940.1 5487035 D 661410 CDS YP_003070941.1 254563846 8194725 complement(5487699..5488616) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; Pyridoxamine 5'-phosphate oxidase-related 5488616 8194725 METDI5525 Methylobacterium extorquens DM4 Pyridoxamine 5'-phosphate oxidase-related YP_003070941.1 5487699 R 661410 CDS YP_003070942.1 254563847 8194726 complement(5488613..5489239) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative glutathione S-transferase 5489239 8194726 METDI5526 Methylobacterium extorquens DM4 putative glutathione S-transferase YP_003070942.1 5488613 R 661410 CDS YP_003070943.1 254563848 8194727 5489384..5490289 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 9084165; Product type r : regulator; transcriptional regulator, LysR family 5490289 8194727 METDI5527 Methylobacterium extorquens DM4 transcriptional regulator, LysR family YP_003070943.1 5489384 D 661410 CDS YP_003070944.1 254563849 8194728 complement(5490318..5491922) 1 NC_012988.1 Catalyzes the reduction of sulfite to sulfide, an essential step in the anaerobic sulfate-respiration pathway; sulfite reductase 5491922 8194728 METDI5528 Methylobacterium extorquens DM4 sulfite reductase YP_003070944.1 5490318 R 661410 CDS YP_003070945.1 254563850 8194729 complement(5491919..5493724) 1 NC_012988.1 ferredoxin-dependent assimilatory nitrite reductase; ferredoxin-nitrite reductase 5493724 nirA 8194729 nirA Methylobacterium extorquens DM4 ferredoxin-nitrite reductase YP_003070945.1 5491919 R 661410 CDS YP_003070946.1 254563851 8194730 complement(5493721..5494941) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative FAD-dependent pyridine nucleotide-disulphide oxidoreductase; putative nitrate or nitrite reductase subunit 5494941 8194730 METDI5530 Methylobacterium extorquens DM4 putative FAD-dependent pyridine nucleotide-disulphide oxidoreductase; putative nitrate or nitrite reductase subunit YP_003070946.1 5493721 R 661410 CDS YP_003070947.1 254563852 8194731 complement(5494967..5495761) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type t : transporter; Nitrate transport ATP-binding subunits C and D 5495761 ntrCD 8194731 ntrCD Methylobacterium extorquens DM4 Nitrate transport ATP-binding subunits C and D YP_003070947.1 5494967 R 661410 CDS YP_003070948.1 254563853 8195785 complement(5495774..5496634) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type t : transporter; Nitrate transport permease protein 5496634 nrtB 8195785 nrtB Methylobacterium extorquens DM4 Nitrate transport permease protein YP_003070948.1 5495774 R 661410 CDS YP_003070949.1 254563854 8195782 complement(5496631..5497923) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 8437564, 8982006, 8990301; Product type t : transporter; nitrate transporter component 5497923 nrtA 8195782 nrtA Methylobacterium extorquens DM4 nitrate transporter component YP_003070949.1 5496631 R 661410 CDS YP_003070950.1 254563855 8195780 complement(5498254..5499270) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8437564, 8982006, 8990301; Product type pt : putative transporter; putative nitrate transporter component, nrtA 5499270 8195780 METDI5534 Methylobacterium extorquens DM4 putative nitrate transporter component, nrtA YP_003070950.1 5498254 R 661410 CDS YP_003070951.1 254563856 8194732 complement(5499267..5499854) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative response regulator: Input and output domains: CheY-like and ANTAR; a phospho receiver domain and an antitermination factor 5499854 8194732 METDI5535 Methylobacterium extorquens DM4 putative response regulator: Input and output domains: CheY-like and ANTAR; a phospho receiver domain and an antitermination factor YP_003070951.1 5499267 R 661410 CDS YP_003070952.1 254563857 8194733 5500107..5500727 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 5500727 8194733 METDI5536 Methylobacterium extorquens DM4 hypothetical protein YP_003070952.1 5500107 D 661410 CDS YP_003070953.1 254563858 8194734 5500940..5502799 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11549021; Product type pe : putative enzyme; putative glycoside hydrolase 5502799 8194734 METDI5537 Methylobacterium extorquens DM4 putative glycoside hydrolase YP_003070953.1 5500940 D 661410 CDS YP_003070954.1 254563859 8194735 5502850..5504925 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 15752350, 8396116; Product type e : enzyme; transketolase 5504925 tkt 8194735 tkt Methylobacterium extorquens DM4 transketolase YP_003070954.1 5502850 D 661410 CDS YP_003070955.1 254563860 8196199 5505146..5507968 1 NC_012988.1 catalyzes the reversible formation of D-erythrose 4-phosphate and D-fructose 6-phosphate from sedoheptulose 7-phosphate and D-glyceraldehyde 3-phosphate; catalyzes isomerization of glucose 6-phosphate and fructose 6-phosphate; bifunctional transaldolase/phosoglucose isomerase 5507968 8196199 METDI5539 Methylobacterium extorquens DM4 bifunctional transaldolase/phosoglucose isomerase YP_003070955.1 5505146 D 661410 CDS YP_003070956.1 254563861 8194736 complement(5508283..5508927) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5508927 8194736 METDI5540 Methylobacterium extorquens DM4 hypothetical protein YP_003070956.1 5508283 R 661410 CDS YP_003070957.1 254563862 8194737 complement(5509011..5509217) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 5509217 8194737 METDI5541 Methylobacterium extorquens DM4 hypothetical protein YP_003070957.1 5509011 R 661410 CDS YP_003070958.1 254563863 8194738 complement(5509349..5510809) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type prc : putative receptor; putative methyl-accepting chemotaxis receptor/sensory transducer with PAS domain 5510809 8194738 METDI5542 Methylobacterium extorquens DM4 putative methyl-accepting chemotaxis receptor/sensory transducer with PAS domain YP_003070958.1 5509349 R 661410 CDS YP_003070959.1 254563864 8194739 complement(5511242..5512114) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5512114 8194739 METDI5543 Methylobacterium extorquens DM4 hypothetical protein YP_003070959.1 5511242 R 661410 CDS YP_003070960.1 254563865 8194740 complement(5512299..5513333) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; Short-chain dehydrogenase/reductase SDR 5513333 8194740 METDI5544 Methylobacterium extorquens DM4 Short-chain dehydrogenase/reductase SDR YP_003070960.1 5512299 R 661410 CDS YP_003070961.1 254563866 8194741 complement(5513500..5516709) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type t : transporter; multidrug transport protein, acriflavin resistance protein F (RND family) 5516709 acrF 8194741 acrF Methylobacterium extorquens DM4 multidrug transport protein, acriflavin resistance protein F (RND family) YP_003070961.1 5513500 R 661410 CDS YP_003070962.1 254563867 8195056 complement(5516872..5518014) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type t : transporter; RND efflux transporter, membrane fusion protein subunit 5518014 8195056 METDI5546 Methylobacterium extorquens DM4 RND efflux transporter, membrane fusion protein subunit YP_003070962.1 5516872 R 661410 CDS YP_003070963.1 254563868 8194742 complement(5518137..5518460) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pe : putative enzyme; rhodanese domain protein, putative sulfur transferase 5518460 8194742 METDI5547 Methylobacterium extorquens DM4 rhodanese domain protein, putative sulfur transferase YP_003070963.1 5518137 R 661410 CDS YP_003070964.1 254563869 8194743 complement(5518509..5519879) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative Glycosyl transferase, group 1 5519879 8194743 METDI5548 Methylobacterium extorquens DM4 putative Glycosyl transferase, group 1 YP_003070964.1 5518509 R 661410 CDS YP_003070965.1 254563870 8194744 complement(5519972..5520520) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 5520520 8194744 METDI5549 Methylobacterium extorquens DM4 hypothetical protein YP_003070965.1 5519972 R 661410 CDS YP_003070966.1 254563871 8194745 complement(5520693..5521328) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 11526037, 11814664, 12620866, 9922236; Product type e : enzyme; autoinducer (N-acylhomoserine lactone) synthase 5521328 8194745 METDI5550 Methylobacterium extorquens DM4 autoinducer (N-acylhomoserine lactone) synthase YP_003070966.1 5520693 R 661410 CDS YP_003070967.1 254563872 8194746 complement(5521809..5522306) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type r : regulator; N-acylhomoserine lactone transcriptional regulator, LuxR family 5522306 8194746 METDI5551 Methylobacterium extorquens DM4 N-acylhomoserine lactone transcriptional regulator, LuxR family YP_003070967.1 5521809 R 661410 CDS YP_003070968.1 254563873 8194748 5523418..5523624 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 5523624 8194748 METDI5553 Methylobacterium extorquens DM4 hypothetical protein YP_003070968.1 5523418 D 661410 CDS YP_003070969.1 254563874 8194749 5523629..5523739 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 5523739 8194749 METDI5554 Methylobacterium extorquens DM4 hypothetical protein YP_003070969.1 5523629 D 661410 CDS YP_003070970.1 254563875 8194750 5524184..5524333 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 5524333 8194750 METDI5555 Methylobacterium extorquens DM4 hypothetical protein YP_003070970.1 5524184 D 661410 CDS YP_003070971.1 254563876 8194751 complement(5524351..5525727) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5525727 8194751 METDI5556 Methylobacterium extorquens DM4 hypothetical protein YP_003070971.1 5524351 R 661410 CDS YP_003070972.1 254563877 8194752 5526250..5526594 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 5526594 8194752 METDI5557 Methylobacterium extorquens DM4 hypothetical protein YP_003070972.1 5526250 D 661410 CDS YP_003070973.1 254563878 8194753 5526673..5526855 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5526855 8194753 METDI5558 Methylobacterium extorquens DM4 hypothetical protein YP_003070973.1 5526673 D 661410 CDS YP_003070974.1 254563879 8194754 5526913..5528229 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5528229 8194754 METDI5559 Methylobacterium extorquens DM4 hypothetical protein YP_003070974.1 5526913 D 661410 CDS YP_003070975.1 254563880 8194757 5528946..5529239 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5529239 8194757 METDI5562 Methylobacterium extorquens DM4 hypothetical protein YP_003070975.1 5528946 D 661410 CDS YP_003070976.1 254563881 8194758 complement(5529398..5531077) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 5531077 8194758 METDI5563 Methylobacterium extorquens DM4 hypothetical protein YP_003070976.1 5529398 R 661410 CDS YP_003070977.1 254563882 8194759 complement(5531267..5531377) 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 5531377 8194759 METDI5564 Methylobacterium extorquens DM4 hypothetical protein YP_003070977.1 5531267 R 661410 CDS YP_003070978.1 254563883 8194760 5531384..5531878 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 5531878 8194760 METDI5565 Methylobacterium extorquens DM4 hypothetical protein YP_003070978.1 5531384 D 661410 CDS YP_003070979.1 254563884 8194762 complement(5532807..5533766) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type r : regulator; Transcriptional regulator, LysR family 5533766 8194762 METDI5568 Methylobacterium extorquens DM4 Transcriptional regulator, LysR family YP_003070979.1 5532807 R 661410 CDS YP_003070980.1 254563885 8194763 5533863..5534114 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 5534114 8194763 METDI5569 Methylobacterium extorquens DM4 hypothetical protein YP_003070980.1 5533863 D 661410 CDS YP_003070981.1 254563886 8194764 complement(5534257..5537451) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type t : transporter; AcrB/AcrD/AcrF family protein 5537451 8194764 METDI5570 Methylobacterium extorquens DM4 AcrB/AcrD/AcrF family protein YP_003070981.1 5534257 R 661410 CDS YP_003070982.1 254563887 8194765 complement(5537454..5538560) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 5538560 8194765 METDI5571 Methylobacterium extorquens DM4 hypothetical protein YP_003070982.1 5537454 R 661410 CDS YP_003070983.1 254563888 8194766 5538799..5539221 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 5539221 8194766 METDI5572 Methylobacterium extorquens DM4 hypothetical protein YP_003070983.1 5538799 D 661410 CDS YP_003070984.1 254563889 8194767 5539322..5539843 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 5539843 8194767 METDI5573 Methylobacterium extorquens DM4 hypothetical protein YP_003070984.1 5539322 D 661410 CDS YP_003070985.1 254563890 8194768 complement(5539856..5541694) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative Quinoprotein alcohol dehydrogenase 5541694 8194768 METDI5574 Methylobacterium extorquens DM4 putative Quinoprotein alcohol dehydrogenase YP_003070985.1 5539856 R 661410 CDS YP_003070986.1 254563891 8194769 5541885..5542157 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 5542157 8194769 METDI5576 Methylobacterium extorquens DM4 hypothetical protein YP_003070986.1 5541885 D 661410 CDS YP_003070987.1 254563892 8194770 complement(5542202..5543347) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type r : regulator; signal transduction histidine kinase; GAF domain 5543347 8194770 METDI5577 Methylobacterium extorquens DM4 signal transduction histidine kinase; GAF domain YP_003070987.1 5542202 R 661410 CDS YP_003070988.1 254563893 8194771 complement(5543648..5544034) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5544034 8194771 METDI5578 Methylobacterium extorquens DM4 hypothetical protein YP_003070988.1 5543648 R 661410 CDS YP_003070989.1 254563894 8194772 complement(5544176..5546527) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative aldehyde dehydrogenase precursor (tat pathway signal) 5546527 8194772 METDI5579 Methylobacterium extorquens DM4 putative aldehyde dehydrogenase precursor (tat pathway signal) YP_003070989.1 5544176 R 661410 CDS YP_003070990.1 254563895 8194773 complement(5546524..5547000) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 8157655; Product type e : enzyme; oxidoreductase, 2Fe-2S subunit 5547000 8194773 METDI5580 Methylobacterium extorquens DM4 oxidoreductase, 2Fe-2S subunit YP_003070990.1 5546524 R 661410 CDS YP_003070991.1 254563896 8194774 complement(5547428..5547805) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5547805 8194774 METDI5581 Methylobacterium extorquens DM4 hypothetical protein YP_003070991.1 5547428 R 661410 CDS YP_003070992.1 254563897 8194775 complement(5548024..5548227) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 5548227 8194775 METDI5582 Methylobacterium extorquens DM4 hypothetical protein YP_003070992.1 5548024 R 661410 CDS YP_003070993.1 254563898 8194776 5548574..5548819 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 5548819 8194776 METDI5583 Methylobacterium extorquens DM4 hypothetical protein YP_003070993.1 5548574 D 661410 CDS YP_003070994.1 254563899 8194777 complement(5548977..5551925) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative phosphoenolpyruvate carboxylase 5551925 8194777 METDI5584 Methylobacterium extorquens DM4 putative phosphoenolpyruvate carboxylase YP_003070994.1 5548977 R 661410 CDS YP_003070995.1 254563900 8194778 5552052..5552618 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 5552618 8194778 METDI5585 Methylobacterium extorquens DM4 hypothetical protein YP_003070995.1 5552052 D 661410 CDS YP_003070996.1 254563901 8194779 5552615..5553487 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 5553487 8194779 METDI5586 Methylobacterium extorquens DM4 hypothetical protein YP_003070996.1 5552615 D 661410 CDS YP_003070997.1 254563902 8194780 5553496..5555169 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; NAD(P)-binding dehydrogenase, putative saccharopine dehydrogenase 5555169 8194780 METDI5587 Methylobacterium extorquens DM4 NAD(P)-binding dehydrogenase, putative saccharopine dehydrogenase YP_003070997.1 5553496 D 661410 CDS YP_003070998.1 254563903 8194781 5555166..5555606 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5555606 8194781 METDI5588 Methylobacterium extorquens DM4 hypothetical protein YP_003070998.1 5555166 D 661410 CDS YP_003070999.1 254563904 8194782 5555741..5556958 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative oxidoreductase precursor (tat pathway signal) 5556958 8194782 METDI5589 Methylobacterium extorquens DM4 putative oxidoreductase precursor (tat pathway signal) YP_003070999.1 5555741 D 661410 CDS YP_003071000.1 254563905 8194783 5557047..5557490 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5557490 8194783 METDI5590 Methylobacterium extorquens DM4 hypothetical protein YP_003071000.1 5557047 D 661410 CDS YP_003071001.1 254563906 8194784 5557823..5558710 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcriptional regulatory protein, LysR family 5558710 8194784 METDI5591 Methylobacterium extorquens DM4 putative transcriptional regulatory protein, LysR family YP_003071001.1 5557823 D 661410 CDS YP_003071002.1 254563907 8194785 complement(5558716..5559738) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; alcohol dehydrogenase 5559738 8194785 METDI5592 Methylobacterium extorquens DM4 alcohol dehydrogenase YP_003071002.1 5558716 R 661410 CDS YP_003071003.1 254563908 8194786 5560098..5563307 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative hybrid histidine kinase; Domains: two PAS, two PAC, two GAF, HWE histidine kinase, ATPase and REC (CheY-like) 5563307 8194786 METDI5593 Methylobacterium extorquens DM4 putative hybrid histidine kinase; Domains: two PAS, two PAC, two GAF, HWE histidine kinase, ATPase and REC (CheY-like) YP_003071003.1 5560098 D 661410 CDS YP_003071004.1 254563909 8194787 complement(5563375..5563659) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 5563659 8194787 METDI5594 Methylobacterium extorquens DM4 hypothetical protein YP_003071004.1 5563375 R 661410 CDS YP_003071005.1 254563910 8194788 complement(5563671..5564444) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11669613, 1556094; Product type e : enzyme; putative 3-oxoacyl-[acyl-carrier-protein] reductase (fabG-like) 5564444 8194788 METDI5595 Methylobacterium extorquens DM4 putative 3-oxoacyl-[acyl-carrier-protein] reductase (fabG-like) YP_003071005.1 5563671 R 661410 CDS YP_003071006.1 254563911 8194789 complement(5564441..5565727) 1 NC_012988.1 FabF, beta-Ketoacyl-ACP synthase II, KASII; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP.; 3-oxoacyl-(acyl carrier protein) synthase II 5565727 8194789 METDI5596 Methylobacterium extorquens DM4 3-oxoacyl-(acyl carrier protein) synthase II YP_003071006.1 5564441 R 661410 CDS YP_003071007.1 254563912 8194790 complement(5565854..5566999) 1 NC_012988.1 FabF; beta-ketoacyl-ACP synthase II, KASII; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP; 3-oxoacyl-(acyl carrier protein) synthase II 5566999 8194790 METDI5597 Methylobacterium extorquens DM4 3-oxoacyl-(acyl carrier protein) synthase II YP_003071007.1 5565854 R 661410 CDS YP_003071008.1 254563913 8194791 complement(5566996..5567460) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8910376; Product type e : enzyme; putative beta-hydroxyacyl-(acyl-carrier-protein) dehydratase (FabZ-like) 5567460 8194791 METDI5598 Methylobacterium extorquens DM4 putative beta-hydroxyacyl-(acyl-carrier-protein) dehydratase (FabZ-like) YP_003071008.1 5566996 R 661410 CDS YP_003071009.1 254563914 8194792 complement(5567489..5567785) 1 NC_012988.1 Involved in the biosynthetic pathways of fatty acids, phospholipids, lipopolysaccharides, and oligosaccharides; acyl carrier protein 5567785 acpXL 8194792 acpXL Methylobacterium extorquens DM4 acyl carrier protein YP_003071009.1 5567489 R 661410 CDS YP_003071010.1 254563915 8195052 complement(5567991..5568479) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 5568479 8195052 METDI5600 Methylobacterium extorquens DM4 hypothetical protein YP_003071010.1 5567991 R 661410 CDS YP_003071011.1 254563916 8194794 5569030..5570109 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5570109 8194794 METDI5602 Methylobacterium extorquens DM4 hypothetical protein YP_003071011.1 5569030 D 661410 CDS YP_003071012.1 254563917 8194795 complement(5570114..5571067) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5571067 8194795 METDI5603 Methylobacterium extorquens DM4 hypothetical protein YP_003071012.1 5570114 R 661410 CDS YP_003071013.1 254563918 8194796 5571164..5571652 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 5571652 8194796 MEDTI5956 Methylobacterium extorquens DM4 hypothetical protein YP_003071013.1 5571164 D 661410 CDS YP_003071014.1 254563919 8190537 5571657..5572070 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative mannose-6-phosphate isomerase 5572070 8190537 METDI5604 Methylobacterium extorquens DM4 putative mannose-6-phosphate isomerase YP_003071014.1 5571657 D 661410 CDS YP_003071015.1 254563920 8194797 5572116..5572412 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5572412 8194797 METDI5605 Methylobacterium extorquens DM4 hypothetical protein YP_003071015.1 5572116 D 661410 CDS YP_003071016.1 254563921 8194798 complement(5572487..5572957) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 12055295, 1356969, 20179655, 93015757, 93315143; Product type f : factor; heat shock chaperone 5572957 ibpA 8194798 ibpA Methylobacterium extorquens DM4 heat shock chaperone YP_003071016.1 5572487 R 661410 CDS YP_003071017.1 254563922 8195587 5573140..5574132 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative lysophospholipase L2 (pldB-like) 5574132 8195587 METDI5607 Methylobacterium extorquens DM4 putative lysophospholipase L2 (pldB-like) YP_003071017.1 5573140 D 661410 CDS YP_003071018.1 254563923 8194799 5574838..5577183 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 5577183 8194799 METDI5608 Methylobacterium extorquens DM4 hypothetical protein YP_003071018.1 5574838 D 661410 CDS YP_003071019.1 254563924 8194800 complement(5577350..5578141) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10747806, 8002619, 9401044; Product type pe : putative enzyme; putative inositol mono-phosphatase (suhB-like) 5578141 8194800 METDI5609 Methylobacterium extorquens DM4 putative inositol mono-phosphatase (suhB-like) YP_003071019.1 5577350 R 661410 CDS YP_003071020.1 254563925 8194801 complement(5578197..5580236) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5580236 8194801 METDI5610 Methylobacterium extorquens DM4 hypothetical protein YP_003071020.1 5578197 R 661410 CDS YP_003071021.1 254563926 8194802 complement(5580477..5581259) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 1729609; Product type pe : putative enzyme; hypothetical protein 5581259 ybgL 8194802 ybgL Methylobacterium extorquens DM4 hypothetical protein YP_003071021.1 5580477 R 661410 CDS YP_003071022.1 254563927 8196351 complement(5581270..5582568) 1 NC_012988.1 catalyzes the formation of nictonate and 5-phospho-alpha-D-ribose 1-diphosphate from nicotinate D-ribonucleotide and diphosphate; nicotinate phosphoribosyltransferase 5582568 8196351 METDI5612 Methylobacterium extorquens DM4 nicotinate phosphoribosyltransferase YP_003071022.1 5581270 R 661410 CDS YP_003071023.1 254563928 8194803 complement(5582725..5583228) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16926146, 8012595, 9384377; Product type pf : putative factor; putative General stress protein 26; putative FMN-binding split barrel domain, putative Pyridoxamine 5'-phosphate oxidase domain 5583228 8194803 METDI5613 Methylobacterium extorquens DM4 putative General stress protein 26; putative FMN-binding split barrel domain, putative Pyridoxamine 5'-phosphate oxidase domain YP_003071023.1 5582725 R 661410 CDS YP_003071024.1 254563929 8194804 5583396..5583668 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 5583668 8194804 METDI5614 Methylobacterium extorquens DM4 hypothetical protein YP_003071024.1 5583396 D 661410 CDS YP_003071025.1 254563930 8194805 5583760..5584887 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 15601724, 2259334, 91080852; Product type t : transporter; antiporter inner membrane protein 5584887 mrp 8194805 mrp Methylobacterium extorquens DM4 antiporter inner membrane protein YP_003071025.1 5583760 D 661410 CDS YP_003071026.1 254563931 8195724 5584941..5585540 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 10978347, 12719427, 20568278, 7551035, 80205, 91286221, 92268047, 93368423; Product type pe : putative enzyme; molybdopterin-guanine dinucleotide biosynthesis protein A 5585540 mobA 8195724 mobA Methylobacterium extorquens DM4 molybdopterin-guanine dinucleotide biosynthesis protein A YP_003071026.1 5584941 D 661410 CDS YP_003071027.1 254563932 8195707 5585851..5588586 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 9278055; Product type e : enzyme; DNA gyrase, subunit A (type II topoisomerase) 5588586 gyrA 8195707 gyrA Methylobacterium extorquens DM4 DNA gyrase, subunit A (type II topoisomerase) YP_003071027.1 5585851 D 661410 CDS YP_003071028.1 254563933 8195543 5588808..5589632 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; putative 31 kDa outer-membrane immunogenic protein precursor (omp31) 5589632 8195543 METDI5618 Methylobacterium extorquens DM4 putative 31 kDa outer-membrane immunogenic protein precursor (omp31) YP_003071028.1 5588808 D 661410 CDS YP_003071029.1 254563934 8194806 5589775..5590278 1 NC_012988.1 Catalyzes the conversion of ATP and pantetheine 4'-phosphate to diphosphate and 3'-dephospho-coA; phosphopantetheine adenylyltransferase 5590278 coaD 8194806 coaD Methylobacterium extorquens DM4 phosphopantetheine adenylyltransferase YP_003071029.1 5589775 D 661410 CDS YP_003071030.1 254563935 8195179 5590321..5590863 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; peptidyl-prolyl cis-trans isomerase (rotamase) precursor 5590863 8195179 METDI5620 Methylobacterium extorquens DM4 peptidyl-prolyl cis-trans isomerase (rotamase) precursor YP_003071030.1 5590321 D 661410 CDS YP_003071031.1 254563936 8194807 5590923..5591369 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 5591369 8194807 METDI5621 Methylobacterium extorquens DM4 hypothetical protein YP_003071031.1 5590923 D 661410 CDS YP_003071032.1 254563937 8194808 5591373..5591834 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; peptidyl-prolyl cis-trans isomerase B (rotamase B)(PPIase B) 5591834 ppiB 8194808 ppiB Methylobacterium extorquens DM4 peptidyl-prolyl cis-trans isomerase B (rotamase B)(PPIase B) YP_003071032.1 5591373 D 661410 CDS YP_003071033.1 254563938 8195883 complement(5591904..5592308) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative response regulator receiver (CheY-like protein) 5592308 8195883 METDI5623 Methylobacterium extorquens DM4 putative response regulator receiver (CheY-like protein) YP_003071033.1 5591904 R 661410 CDS YP_003071034.1 254563939 8194809 5592725..5593462 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15886391; Product type pe : putative enzyme; putative damage-inducible mutagenesis protein (ImuA-like) 5593462 8194809 METDI5624 Methylobacterium extorquens DM4 putative damage-inducible mutagenesis protein (ImuA-like) YP_003071034.1 5592725 D 661410 CDS YP_003071035.1 254563940 8194810 5593476..5594879 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15886391; Product type pe : putative enzyme; putative damage-inducible mutagenesis protein (ImuB-like) 5594879 8194810 METDI5625 Methylobacterium extorquens DM4 putative damage-inducible mutagenesis protein (ImuB-like) YP_003071035.1 5593476 D 661410 CDS YP_003071036.1 254563941 8194811 5594986..5598189 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; error-prone DNA polymerase, DNA polymerase III, alpha subunit 5598189 dnaE 8194811 dnaE Methylobacterium extorquens DM4 error-prone DNA polymerase, DNA polymerase III, alpha subunit YP_003071036.1 5594986 D 661410 CDS YP_003071037.1 254563942 8195305 5598345..5598557 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5598557 8195305 METDI5627 Methylobacterium extorquens DM4 hypothetical protein YP_003071037.1 5598345 D 661410 CDS YP_003071038.1 254563943 8194812 5598783..5599808 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative patatin-like phospholipase 5599808 8194812 METDI5628 Methylobacterium extorquens DM4 putative patatin-like phospholipase YP_003071038.1 5598783 D 661410 CDS YP_003071039.1 254563944 8194813 complement(5599973..5600743) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative ionic voltage-gated channel protein 5600743 8194813 METDI5629 Methylobacterium extorquens DM4 putative ionic voltage-gated channel protein YP_003071039.1 5599973 R 661410 CDS YP_003071040.1 254563945 8194814 complement(5600771..5600947) 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 5600947 8194814 METDI5630 Methylobacterium extorquens DM4 hypothetical protein YP_003071040.1 5600771 R 661410 CDS YP_003071041.1 254563946 8194815 5601253..5601564 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 5601564 8194815 METDI5631 Methylobacterium extorquens DM4 hypothetical protein YP_003071041.1 5601253 D 661410 CDS YP_003071042.1 254563947 8194816 5601628..5603346 1 NC_012988.1 Evidence 1a : Function experimentally demonstrated in the studied strain; Product type e : enzyme; Tungsten-containing formate dehydrogenase beta subunit 5603346 fdh1B 8194816 fdh1B Methylobacterium extorquens DM4 Tungsten-containing formate dehydrogenase beta subunit YP_003071042.1 5601628 D 661410 CDS YP_003071043.1 254563948 8195361 5603399..5606368 1 NC_012988.1 Evidence 1c : Function experimentally demonstrated in the studied genus; Product type e : enzyme; Tungsten-containing formate dehydrogenase alpha subunit 5606368 fdh1A 8195361 fdh1A Methylobacterium extorquens DM4 Tungsten-containing formate dehydrogenase alpha subunit YP_003071043.1 5603399 D 661410 CDS YP_003071044.1 254563949 8195360 complement(5606640..5607992) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5607992 8195360 METDI5635 Methylobacterium extorquens DM4 hypothetical protein YP_003071044.1 5606640 R 661410 CDS YP_003071045.1 254563950 8194817 complement(5608007..5609005) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 5609005 8194817 METDI5636 Methylobacterium extorquens DM4 hypothetical protein YP_003071045.1 5608007 R 661410 CDS YP_003071046.1 254563951 8194818 5609210..5610040 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5610040 8194818 METDI5637 Methylobacterium extorquens DM4 hypothetical protein YP_003071046.1 5609210 D 661410 CDS YP_003071047.1 254563952 8194819 5610178..5611308 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 5611308 8194819 METDI5638 Methylobacterium extorquens DM4 hypothetical protein YP_003071047.1 5610178 D 661410 CDS YP_003071048.1 254563953 8194820 5611805..5612257 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 5612257 8194820 METDI5639 Methylobacterium extorquens DM4 hypothetical protein YP_003071048.1 5611805 D 661410 CDS YP_003071049.1 254563954 8194821 complement(5612379..5614445) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 5614445 8194821 METDI5640 Methylobacterium extorquens DM4 hypothetical protein YP_003071049.1 5612379 R 661410 CDS YP_003071050.1 254563955 8194822 complement(5614442..5616565) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8226645, 8226646, 8246891; Product type pt : putative transporter; putative succinoglycan biosynthesis transport protein 5616565 8194822 METDI5641 Methylobacterium extorquens DM4 putative succinoglycan biosynthesis transport protein YP_003071050.1 5614442 R 661410 CDS YP_003071051.1 254563956 8194823 complement(5616744..5618114) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 5618114 8194823 METDI5642 Methylobacterium extorquens DM4 hypothetical protein YP_003071051.1 5616744 R 661410 CDS YP_003071052.1 254563957 8194824 complement(5618455..5619399) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5619399 8194824 METDI5643 Methylobacterium extorquens DM4 hypothetical protein YP_003071052.1 5618455 R 661410 CDS YP_003071053.1 254563958 8194825 complement(5619675..5620418) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11669613; Product type e : enzyme; putative 3-oxoacyl-acyl carrier protein reductase (fabG-like) 5620418 8194825 METDI5644 Methylobacterium extorquens DM4 putative 3-oxoacyl-acyl carrier protein reductase (fabG-like) YP_003071053.1 5619675 R 661410 CDS YP_003071054.1 254563959 8194826 complement(5620415..5621776) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative o-succinylbenzoate--CoA ligase 5621776 8194826 METDI5645 Methylobacterium extorquens DM4 putative o-succinylbenzoate--CoA ligase YP_003071054.1 5620415 R 661410 CDS YP_003071055.1 254563960 8194827 complement(5621782..5622039) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5622039 8194827 METDI5646 Methylobacterium extorquens DM4 hypothetical protein YP_003071055.1 5621782 R 661410 CDS YP_003071056.1 254563961 8194828 complement(5622080..5622997) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 9401025; Product type pe : putative enzyme; putative lipase/esterase (aes-like) 5622997 8194828 METDI5647 Methylobacterium extorquens DM4 putative lipase/esterase (aes-like) YP_003071056.1 5622080 R 661410 CDS YP_003071057.1 254563962 8194829 complement(5623014..5623946) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; hypothetical protein 5623946 8194829 METDI5648 Methylobacterium extorquens DM4 hypothetical protein YP_003071057.1 5623014 R 661410 CDS YP_003071058.1 254563963 8194830 complement(5624120..5625322) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; acyl-CoA dehydrogenase 5625322 acd 8194830 acd Methylobacterium extorquens DM4 acyl-CoA dehydrogenase YP_003071058.1 5624120 R 661410 CDS YP_003071059.1 254563964 8195048 complement(5625416..5625685) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5625685 8195048 METDI5650 Methylobacterium extorquens DM4 hypothetical protein YP_003071059.1 5625416 R 661410 CDS YP_003071060.1 254563965 8194831 complement(5625820..5626407) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 1527048, 7665508, 7665509; Product type pe : putative enzyme; putative monooxygenase, small component; putative flavin:NADH reductase 5626407 8194831 METDI5651 Methylobacterium extorquens DM4 putative monooxygenase, small component; putative flavin:NADH reductase YP_003071060.1 5625820 R 661410 CDS YP_003071061.1 254563966 8194832 5626703..5628406 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; thiamine pyrophosphate protein 5628406 8194832 METDI5652 Methylobacterium extorquens DM4 thiamine pyrophosphate protein YP_003071061.1 5626703 D 661410 CDS YP_003071062.1 254563967 8194833 5628536..5628859 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 5628859 8194833 METDI5653 Methylobacterium extorquens DM4 hypothetical protein YP_003071062.1 5628536 D 661410 CDS YP_003071063.1 254563968 8194834 complement(5628904..5629785) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; aminotransferase 5629785 8194834 METDI5654 Methylobacterium extorquens DM4 aminotransferase YP_003071063.1 5628904 R 661410 CDS YP_003071064.1 254563969 8194835 complement(5629973..5630407) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5630407 8194835 METDI5655 Methylobacterium extorquens DM4 hypothetical protein YP_003071064.1 5629973 R 661410 CDS YP_003071065.1 254563970 8194836 5630901..5632193 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 12951250, 9506902; Product type e : enzyme; trans-sulfuration enzyme (O-acetylhomoserine aminocarboxypropyltransferase) 5632193 metY-3 8194836 metY-3 Methylobacterium extorquens DM4 trans-sulfuration enzyme (O-acetylhomoserine aminocarboxypropyltransferase) YP_003071065.1 5630901 D 661410 CDS YP_003071066.1 254563971 8195690 5632227..5633222 1 NC_012988.1 catalyzes the formation of O-succinyl-L-homoserine from succinyl-CoA and L-homoserine in methionine biosynthesis; homoserine O-succinyltransferase 5633222 8195690 METDI5657 Methylobacterium extorquens DM4 homoserine O-succinyltransferase YP_003071066.1 5632227 D 661410 CDS YP_003071067.1 254563972 8194837 5633234..5635063 1 NC_012988.1 activates fatty acids by binding to coenzyme A; may be involved in acyclic terpene utilization; long-chain-acyl-CoA synthetase 5635063 8194837 METDI5658 Methylobacterium extorquens DM4 long-chain-acyl-CoA synthetase YP_003071067.1 5633234 D 661410 CDS YP_003071068.1 254563973 8194838 complement(5635106..5636425) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 7476194; Product type pm : putative membrane component; putative EPS I polysaccharide export inner membrane protein (epsE-like) 5636425 8194838 METDI5659 Methylobacterium extorquens DM4 putative EPS I polysaccharide export inner membrane protein (epsE-like) YP_003071068.1 5635106 R 661410 CDS YP_003071069.1 254563974 8194839 5636679..5639015 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 5639015 8194839 METDI5660 Methylobacterium extorquens DM4 hypothetical protein YP_003071069.1 5636679 D 661410 CDS YP_003071070.1 254563975 8194840 5639012..5639899 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 5639899 8194840 METDI5661 Methylobacterium extorquens DM4 hypothetical protein YP_003071070.1 5639012 D 661410 CDS YP_003071071.1 254563976 8194841 complement(5640083..5642038) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5642038 8194841 METDI5662 Methylobacterium extorquens DM4 hypothetical protein YP_003071071.1 5640083 R 661410 CDS YP_003071072.1 254563977 8194842 complement(5642272..5642613) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative pH adaptation potassium efflux system component (phaG) 5642613 8194842 METDI5663 Methylobacterium extorquens DM4 putative pH adaptation potassium efflux system component (phaG) YP_003071072.1 5642272 R 661410 CDS YP_003071073.1 254563978 8194843 complement(5642610..5642894) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative pH adaptation potassium efflux system component (phaF) 5642894 8194843 METDI5664 Methylobacterium extorquens DM4 putative pH adaptation potassium efflux system component (phaF) YP_003071073.1 5642610 R 661410 CDS YP_003071074.1 254563979 8194844 complement(5642891..5643379) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative pH adaptation potassium efflux system component(phaE) 5643379 8194844 METDI5665 Methylobacterium extorquens DM4 putative pH adaptation potassium efflux system component(phaE) YP_003071074.1 5642891 R 661410 CDS YP_003071075.1 254563980 8194845 complement(5643376..5645046) 1 NC_012988.1 subunit D of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; contains an oxidoreductase domain; catalyzes the transfer of electrons from NADH to ubiquinone; putative monovalent cation/H+ antiporter subunit D 5645046 8194845 METDI5666 Methylobacterium extorquens DM4 putative monovalent cation/H+ antiporter subunit D YP_003071075.1 5643376 R 661410 CDS YP_003071076.1 254563981 8194846 complement(5645043..5645411) 1 NC_012988.1 subunit C of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; putative monovalent cation/H+ antiporter subunit C 5645411 8194846 METDI5667 Methylobacterium extorquens DM4 putative monovalent cation/H+ antiporter subunit C YP_003071076.1 5645043 R 661410 CDS YP_003071077.1 254563982 8194847 complement(5645411..5648350) 1 NC_012988.1 subunit A of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; in S. meliloti it is known to be involved with K+; putative monovalent cation/H+ antiporter subunit A 5648350 8194847 METDI5668 Methylobacterium extorquens DM4 putative monovalent cation/H+ antiporter subunit A YP_003071077.1 5645411 R 661410 CDS YP_003071078.1 254563983 8194848 complement(5648783..5649004) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 5649004 8194848 METDI5669 Methylobacterium extorquens DM4 hypothetical protein YP_003071078.1 5648783 R 661410 CDS YP_003071079.1 254563984 8194849 5649466..5650803 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative UDP-N-acetyl-D-mannosaminuronic acid dehydrogenase 5650803 8194849 METDI5670 Methylobacterium extorquens DM4 putative UDP-N-acetyl-D-mannosaminuronic acid dehydrogenase YP_003071079.1 5649466 D 661410 CDS YP_003071080.1 254563985 8194850 5650800..5651771 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative UDP-glucose 4-epimerase 5651771 8194850 METDI5671 Methylobacterium extorquens DM4 putative UDP-glucose 4-epimerase YP_003071080.1 5650800 D 661410 CDS YP_003071081.1 254563986 8194851 5651782..5652720 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 9473059, 9862812; Product type e : enzyme; bifunctional GDP-fucose synthetase: GDP-4-dehydro-6-deoxy-D-mannose epimerase; GDP-4-dehydro-6-L-deoxygalactose reductase 5652720 fcl 8194851 fcl Methylobacterium extorquens DM4 bifunctional GDP-fucose synthetase: GDP-4-dehydro-6-deoxy-D-mannose epimerase; GDP-4-dehydro-6-L-deoxygalactose reductase YP_003071081.1 5651782 D 661410 CDS YP_003071082.1 254563987 8195359 5652704..5653588 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 9157246; Product type pe : putative enzyme; putative glycosyl transferase, WecB/TagA/CpsF family 5653588 8195359 METDI5673 Methylobacterium extorquens DM4 putative glycosyl transferase, WecB/TagA/CpsF family YP_003071082.1 5652704 D 661410 CDS YP_003071083.1 254563988 8194852 5653600..5654772 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10531370; Product type pe : putative enzyme; putative glycosyl transferase 5654772 8194852 METDI5674 Methylobacterium extorquens DM4 putative glycosyl transferase YP_003071083.1 5653600 D 661410 CDS YP_003071084.1 254563989 8194853 complement(5654937..5655104) 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 5655104 8194853 METDI5675 Methylobacterium extorquens DM4 hypothetical protein YP_003071084.1 5654937 R 661410 CDS YP_003071085.1 254563990 8194854 complement(5655220..5657805) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 5657805 8194854 METDI5676 Methylobacterium extorquens DM4 hypothetical protein YP_003071085.1 5655220 R 661410 CDS YP_003071086.1 254563991 8194855 complement(5657802..5661263) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative enterobactin synthase multienzyme complex component, ATP-dependent 5661263 8194855 METDI5677 Methylobacterium extorquens DM4 putative enterobactin synthase multienzyme complex component, ATP-dependent YP_003071086.1 5657802 R 661410 CDS YP_003071087.1 254563992 8194856 complement(5661592..5662812) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 12910271; hypothetical protein 5662812 8194856 METDI5678 Methylobacterium extorquens DM4 hypothetical protein YP_003071087.1 5661592 R 661410 CDS YP_003071088.1 254563993 8194857 complement(5662952..5663479) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; Phosphoglycerate/bisphosphoglycerate mutase 5663479 8194857 METDI5679 Methylobacterium extorquens DM4 Phosphoglycerate/bisphosphoglycerate mutase YP_003071088.1 5662952 R 661410 CDS YP_003071089.1 254563994 8194858 complement(5663479..5664471) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 15292217, 16077126; Product type e : enzyme; NAD(P)-dependent aldo/keto reductase 5664471 8194858 METDI5680 Methylobacterium extorquens DM4 NAD(P)-dependent aldo/keto reductase YP_003071089.1 5663479 R 661410 CDS YP_003071090.1 254563995 8194859 complement(5664518..5665369) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; AAA ATPase 5665369 8194859 METDI5681 Methylobacterium extorquens DM4 AAA ATPase YP_003071090.1 5664518 R 661410 CDS YP_003071091.1 254563996 8194860 complement(5665465..5666118) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 5666118 8194860 METDI5682 Methylobacterium extorquens DM4 hypothetical protein YP_003071091.1 5665465 R 661410 CDS YP_003071092.1 254563997 8194861 complement(5666245..5667483) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 5667483 8194861 METDI5683 Methylobacterium extorquens DM4 hypothetical protein YP_003071092.1 5666245 R 661410 CDS YP_003071093.1 254563998 8194862 5667786..5669678 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 3301813; Product type pt : putative transporter; putative glutathione-regulated potassium-efflux system protein (kefB/C-like) 5669678 8194862 METDI5684 Methylobacterium extorquens DM4 putative glutathione-regulated potassium-efflux system protein (kefB/C-like) YP_003071093.1 5667786 D 661410 CDS YP_003071094.1 254563999 8194863 complement(5669713..5671080) 1 NC_012988.1 UDP-N-acetylmuramoylalanine--D-glutamate ligase; involved in peptidoglycan biosynthesis; cytoplasmic; catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine during cell wall formation; UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase 5671080 murD 8194863 murD Methylobacterium extorquens DM4 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase YP_003071094.1 5669713 R 661410 CDS YP_003071095.1 254564000 8195739 complement(5671105..5672187) 1 NC_012988.1 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; phospho-N-acetylmuramoyl-pentapeptide- transferase 5672187 mraY 8195739 mraY Methylobacterium extorquens DM4 phospho-N-acetylmuramoyl-pentapeptide- transferase YP_003071095.1 5671105 R 661410 CDS YP_003071096.1 254564001 8195723 complement(5672293..5673756) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 11090285; Product type e : enzyme; UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase 5673756 murF 8195723 murF Methylobacterium extorquens DM4 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase YP_003071096.1 5672293 R 661410 CDS YP_003071097.1 254564002 8195741 complement(5673753..5675231) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 2269304, 7486937; Product type e : enzyme; UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase 5675231 murE 8195741 murE Methylobacterium extorquens DM4 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase YP_003071097.1 5673753 R 661410 CDS YP_003071098.1 254564003 8195740 complement(5675291..5677168) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 3126399; Product type e : enzyme; Peptidoglycan glycosyltransferase (penicillin-binding protein) 5677168 ftsI 8195740 ftsI Methylobacterium extorquens DM4 Peptidoglycan glycosyltransferase (penicillin-binding protein) YP_003071098.1 5675291 R 661410 CDS YP_003071099.1 254564004 8195452 complement(5677176..5677607) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5677607 8195452 METDI5690 Methylobacterium extorquens DM4 hypothetical protein YP_003071099.1 5677176 R 661410 CDS YP_003071100.1 254564005 8194864 complement(5677604..5678659) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; S-adenosyl-methyltransferase MraW 5678659 mraW 8194864 mraW Methylobacterium extorquens DM4 S-adenosyl-methyltransferase MraW YP_003071100.1 5677604 R 661410 CDS YP_003071101.1 254564006 8196005 complement(5679568..5682012) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 4377758; Product type e : enzyme; DNA ligase, NAD(+)-dependent 5682012 dnlJ 8196005 dnlJ Methylobacterium extorquens DM4 DNA ligase, NAD(+)-dependent YP_003071101.1 5679568 R 661410 CDS YP_003071102.1 254564007 8195312 5682128..5682448 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 5682448 8195312 METDI5693 Methylobacterium extorquens DM4 hypothetical protein YP_003071102.1 5682128 D 661410 CDS YP_003071103.1 254564008 8194865 5682619..5682978 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5682978 8194865 METDI5694 Methylobacterium extorquens DM4 hypothetical protein YP_003071103.1 5682619 D 661410 CDS YP_003071104.1 254564009 8194866 5683055..5684068 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; Carbohydrate kinase, PfkB 5684068 8194866 METDI5695 Methylobacterium extorquens DM4 Carbohydrate kinase, PfkB YP_003071104.1 5683055 D 661410 CDS YP_003071105.1 254564010 8194867 complement(5684120..5684542) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 1371354; Product type e : enzyme; peptidyl-prolyl cis-trans isomerase (Rotamase) 5684542 fbp 8194867 fbp Methylobacterium extorquens DM4 peptidyl-prolyl cis-trans isomerase (Rotamase) YP_003071105.1 5684120 R 661410 CDS YP_003071106.1 254564011 8195356 complement(5684610..5685077) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 5685077 8195356 METDI5697 Methylobacterium extorquens DM4 hypothetical protein YP_003071106.1 5684610 R 661410 CDS YP_003071107.1 254564012 8194868 5685400..5686638 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative L-carnitine dehydratase; putative acyl-CoA-transferase, NAD(P)-binding 5686638 8194868 METDI5698 Methylobacterium extorquens DM4 putative L-carnitine dehydratase; putative acyl-CoA-transferase, NAD(P)-binding YP_003071107.1 5685400 D 661410 CDS YP_003071108.1 254564013 8194869 5686662..5687486 1 NC_012988.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase 5687486 croA 8194869 croA Methylobacterium extorquens DM4 enoyl-CoA hydratase YP_003071108.1 5686662 D 661410 CDS YP_003071109.1 254564014 8195214 complement(5687518..5688144) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcriptional regulator, GntR family 5688144 8195214 METDI5700 Methylobacterium extorquens DM4 putative transcriptional regulator, GntR family YP_003071109.1 5687518 R 661410 CDS YP_003071110.1 254564015 8194870 5688474..5689517 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative L-allo-threonine aldolase (ltaE-like) 5689517 8194870 METDI5701 Methylobacterium extorquens DM4 putative L-allo-threonine aldolase (ltaE-like) YP_003071110.1 5688474 D 661410 CDS YP_003071111.1 254564016 8194871 complement(5689648..5690193) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5690193 8194871 METDI5702 Methylobacterium extorquens DM4 hypothetical protein YP_003071111.1 5689648 R 661410 CDS YP_003071112.1 254564017 8194872 complement(5690277..5691404) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5691404 8194872 METDI5703 Methylobacterium extorquens DM4 hypothetical protein YP_003071112.1 5690277 R 661410 CDS YP_003071113.1 254564018 8194873 complement(5691474..5691845) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5691845 8194873 METDI5704 Methylobacterium extorquens DM4 hypothetical protein YP_003071113.1 5691474 R 661410 CDS YP_003071114.1 254564019 8194874 complement(5691842..5693551) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5693551 8194874 METDI5705 Methylobacterium extorquens DM4 hypothetical protein YP_003071114.1 5691842 R 661410 CDS YP_003071115.1 254564020 8194875 complement(5693569..5694021) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5694021 8194875 METDI5706 Methylobacterium extorquens DM4 hypothetical protein YP_003071115.1 5693569 R 661410 CDS YP_003071116.1 254564021 8194876 5694182..5694475 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 5694475 8194876 METDI5707 Methylobacterium extorquens DM4 hypothetical protein YP_003071116.1 5694182 D 661410 CDS YP_003071117.1 254564022 8194877 complement(5694553..5695716) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative synthetase/amidase 5695716 8194877 METDI5708 Methylobacterium extorquens DM4 putative synthetase/amidase YP_003071117.1 5694553 R 661410 CDS YP_003071118.1 254564023 8194878 complement(5695716..5696348) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5696348 8194878 METDI5709 Methylobacterium extorquens DM4 hypothetical protein YP_003071118.1 5695716 R 661410 CDS YP_003071119.1 254564024 8194879 complement(5696353..5696751) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; putative inner membrane protein 5696751 8194879 METDI5710 Methylobacterium extorquens DM4 putative inner membrane protein YP_003071119.1 5696353 R 661410 CDS YP_003071120.1 254564025 8194880 complement(5696771..5698399) 1 NC_012988.1 CTP synthase; cytidine triphosphate synthetase; catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen; in Escherichia coli this enzyme forms a homotetramer; CTP synthetase 5698399 pyrG 8194880 pyrG Methylobacterium extorquens DM4 CTP synthetase YP_003071120.1 5696771 R 661410 CDS YP_003071121.1 254564026 8195952 complement(5698592..5699059) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type pt : putative transporter; putative secG: preprotein translocase 5699059 secG 8195952 secG Methylobacterium extorquens DM4 putative secG: preprotein translocase YP_003071121.1 5698592 R 661410 CDS YP_003071122.1 254564027 8196107 5699362..5699643 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 5699643 8196107 METDI5713 Methylobacterium extorquens DM4 hypothetical protein YP_003071122.1 5699362 D 661410 CDS YP_003071123.1 254564028 8194881 5699664..5700128 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5700128 8194881 METDI5714 Methylobacterium extorquens DM4 hypothetical protein YP_003071123.1 5699664 D 661410 CDS YP_003071124.1 254564029 8194882 complement(5700153..5700422) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 5700422 8194882 METDI5715 Methylobacterium extorquens DM4 hypothetical protein YP_003071124.1 5700153 R 661410 CDS YP_003071125.1 254564030 8194883 complement(5700663..5701427) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 6092857, 8021172, 9202469; Product type e : enzyme; triosephosphate isomerase 5701427 tpiA 8194883 tpiA Methylobacterium extorquens DM4 triosephosphate isomerase YP_003071125.1 5700663 R 661410 CDS YP_003071126.1 254564031 8196207 5701662..5703566 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 9670013; Product type pe : putative enzyme; putative peptidyl-prolyl cis-trans isomerse D 5703566 8196207 METDI5717 Methylobacterium extorquens DM4 putative peptidyl-prolyl cis-trans isomerse D YP_003071126.1 5701662 D 661410 CDS YP_003071127.1 254564032 8194884 5703576..5705096 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 12694904; Product type e : enzyme; anthranilate synthase component I 5705096 trpE 8194884 trpE Methylobacterium extorquens DM4 anthranilate synthase component I YP_003071127.1 5703576 D 661410 CDS YP_003071128.1 254564033 8196276 complement(5705158..5706849) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative methyl-accepting chemotaxis sensory transducer precursor; histidine kinase HAMP domain 5706849 8196276 METDI5719 Methylobacterium extorquens DM4 putative methyl-accepting chemotaxis sensory transducer precursor; histidine kinase HAMP domain YP_003071128.1 5705158 R 661410 CDS YP_003071129.1 254564034 8194885 complement(5706912..5707088) 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 5707088 8194885 METDI5720 Methylobacterium extorquens DM4 hypothetical protein YP_003071129.1 5706912 R 661410 CDS YP_003071130.1 254564035 8194886 5707128..5707730 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 1896020, 2105306; Product type e : enzyme; aminodeoxychorismate synthase component II, Glutamine amido-transferase 5707730 trpG 8194886 trpG Methylobacterium extorquens DM4 aminodeoxychorismate synthase component II, Glutamine amido-transferase YP_003071130.1 5707128 D 661410 CDS YP_003071131.1 254564036 8196278 5707819..5708832 1 NC_012988.1 Catalyzes the conversion of N-(5-phospho-D-ribosyl)-anthranilate and diphosphate to anthranilate and 5-phospho-alpha-D-ribose 1-diphosphate; anthranilate phosphoribosyltransferase 5708832 trpD 8196278 trpD Methylobacterium extorquens DM4 anthranilate phosphoribosyltransferase YP_003071131.1 5707819 D 661410 CDS YP_003071132.1 254564037 8196275 5708866..5709723 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 12597275, 9061023; Product type e : enzyme; indole-3-glycerol phosphate synthase 5709723 trpC 8196275 trpC Methylobacterium extorquens DM4 indole-3-glycerol phosphate synthase YP_003071132.1 5708866 D 661410 CDS YP_003071133.1 254564038 8196274 5709720..5710205 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 10903949, 9061023, 93368423; Product type e : enzyme; molybdenum cofactor biosynthesis protein C 5710205 moaC 8196274 moaC Methylobacterium extorquens DM4 molybdenum cofactor biosynthesis protein C YP_003071133.1 5709720 D 661410 CDS YP_003071134.1 254564039 8195704 5710202..5711428 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 9515915; Product type pf : putative factor; putative molybdopterin biosynthesis-related protein 5711428 8195704 METDI5725 Methylobacterium extorquens DM4 putative molybdopterin biosynthesis-related protein YP_003071134.1 5710202 D 661410 CDS YP_003071135.1 254564040 8194887 5711519..5711848 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5711848 8194887 METDI5726 Methylobacterium extorquens DM4 hypothetical protein YP_003071135.1 5711519 D 661410 CDS YP_003071136.1 254564041 8194888 5711859..5712152 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcriptional regulator, XRE family 5712152 8194888 METDI5727 Methylobacterium extorquens DM4 putative transcriptional regulator, XRE family YP_003071136.1 5711859 D 661410 CDS YP_003071137.1 254564042 8194889 5712324..5712785 1 NC_012988.1 in Pseudomonas aeruginosa this enzyme is a trimer of dimers; essential for membrane formation; performs third step of type II fatty acid biosynthesis; catalyzes dehydration of (3R)-hydroxyacyl-ACP to trans-2-acyl-ACP; (3R)-hydroxymyristoyl-ACP dehydratase 5712785 fabZ 8194889 fabZ Methylobacterium extorquens DM4 (3R)-hydroxymyristoyl-ACP dehydratase YP_003071137.1 5712324 D 661410 CDS YP_003071138.1 254564043 8195350 5712791..5713597 1 NC_012988.1 catalyzes the addition of (R)-3-hydroxytetradecanoyl to the glucosamine disaccharide in lipid A biosynthesis; UDP-N-acetylglucosamine acyltransferase 5713597 lpxA 8195350 lpxA Methylobacterium extorquens DM4 UDP-N-acetylglucosamine acyltransferase YP_003071138.1 5712791 D 661410 CDS YP_003071139.1 254564044 8195646 5713609..5714457 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5714457 8195646 METDI5730 Methylobacterium extorquens DM4 hypothetical protein YP_003071139.1 5713609 D 661410 CDS YP_003071140.1 254564045 8194890 5714454..5715614 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 3277952, 8917090; Product type e : enzyme; Lipid-A-disaccharide synthase 5715614 lpxB 8194890 lpxB Methylobacterium extorquens DM4 Lipid-A-disaccharide synthase YP_003071140.1 5714454 D 661410 CDS YP_003071141.1 254564046 8195647 5715611..5716090 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5716090 8195647 METDI5732 Methylobacterium extorquens DM4 hypothetical protein YP_003071141.1 5715611 D 661410 CDS YP_003071142.1 254564047 8194891 complement(5716236..5717525) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 1939121; Product type e : enzyme; citrate synthase 5717525 gltA 8194891 gltA Methylobacterium extorquens DM4 citrate synthase YP_003071142.1 5716236 R 661410 CDS YP_003071143.1 254564048 8195511 complement(5718001..5719425) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; glutamate tRNA synthetase, catalytic subunit 5719425 gltX 8195511 gltX Methylobacterium extorquens DM4 glutamate tRNA synthetase, catalytic subunit YP_003071143.1 5718001 R 661410 CDS YP_003071144.1 254564049 8195517 5719593..5721851 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5721851 8195517 METDI5735 Methylobacterium extorquens DM4 hypothetical protein YP_003071144.1 5719593 D 661410 CDS YP_003071145.1 254564050 8194892 complement(5721845..5722621) 1 NC_012988.1 Represses a number of genes involved in the response to DNA damage; LexA repressor 5722621 lexA 8194892 lexA Methylobacterium extorquens DM4 LexA repressor YP_003071145.1 5721845 R 661410 CDS YP_003071146.1 254564051 8195633 5722949..5723743 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 5723743 8195633 METDI5737 Methylobacterium extorquens DM4 hypothetical protein YP_003071146.1 5722949 D 661410 CDS YP_003071147.1 254564052 8194893 5724047..5725402 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 2053984, 8419306; Product type t : transporter; alpha-ketoglutarate permease (MFS transporter membrane protein) 5725402 kgtP 8194893 kgtP Methylobacterium extorquens DM4 alpha-ketoglutarate permease (MFS transporter membrane protein) YP_003071147.1 5724047 D 661410 CDS YP_003071148.1 254564053 8195624 complement(5725515..5726339) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5726339 8195624 METDI5740 Methylobacterium extorquens DM4 hypothetical protein YP_003071148.1 5725515 R 661410 CDS YP_003071149.1 254564054 8194894 complement(5726353..5727432) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 12356321, 2184888, 8457548; Product type e : enzyme; Tartrate dehydrogenase/decarboxylase (TDH) (D-malate dehydrogenase [decarboxylating]) 5727432 ttuC 8194894 ttuC Methylobacterium extorquens DM4 Tartrate dehydrogenase/decarboxylase (TDH) (D-malate dehydrogenase [decarboxylating]) YP_003071149.1 5726353 R 661410 CDS YP_003071150.1 254564055 8196288 complement(5727572..5728033) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 5728033 8196288 METDI5742 Methylobacterium extorquens DM4 hypothetical protein YP_003071150.1 5727572 R 661410 CDS YP_003071151.1 254564056 8194895 complement(5728143..5729021) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative oxidoreductase, aldo/keto reductase family 5729021 8194895 METDI5743 Methylobacterium extorquens DM4 putative oxidoreductase, aldo/keto reductase family YP_003071151.1 5728143 R 661410 CDS YP_003071152.1 254564057 8194896 complement(5729103..5729828) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5729828 8194896 METDI5744 Methylobacterium extorquens DM4 hypothetical protein YP_003071152.1 5729103 R 661410 CDS YP_003071153.1 254564058 8194897 complement(5730024..5731955) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5731955 8194897 METDI5745 Methylobacterium extorquens DM4 hypothetical protein YP_003071153.1 5730024 R 661410 CDS YP_003071154.1 254564059 8194898 complement(5732398..5733909) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type e : enzyme; periplasmic serine protease (DegP) 5733909 depP 8194898 depP Methylobacterium extorquens DM4 periplasmic serine protease (DegP) YP_003071154.1 5732398 R 661410 CDS YP_003071155.1 254564060 8195291 complement(5734023..5734775) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5734775 8195291 METDI5747 Methylobacterium extorquens DM4 hypothetical protein YP_003071155.1 5734023 R 661410 CDS YP_003071156.1 254564061 8194899 complement(5734772..5737621) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 182209, 8611551; Product type e : enzyme; valine tRNA synthetase 5737621 valS 8194899 valS Methylobacterium extorquens DM4 valine tRNA synthetase YP_003071156.1 5734772 R 661410 CDS YP_003071157.1 254564062 8196333 complement(5737936..5738484) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5738484 8196333 METDI5749 Methylobacterium extorquens DM4 hypothetical protein YP_003071157.1 5737936 R 661410 CDS YP_003071158.1 254564063 8194900 complement(5738658..5740169) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; putative type I secretion outer membrane protein, TolC precursor 5740169 8194900 METDI5750 Methylobacterium extorquens DM4 putative type I secretion outer membrane protein, TolC precursor YP_003071158.1 5738658 R 661410 CDS YP_003071159.1 254564064 8194901 complement(5740691..5741341) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; hypothetical protein 5741341 8194901 METDI5751 Methylobacterium extorquens DM4 hypothetical protein YP_003071159.1 5740691 R 661410 CDS YP_003071160.1 254564065 8196251 5743089..5743391 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 5743391 8196251 METDI5753 Methylobacterium extorquens DM4 hypothetical protein YP_003071160.1 5743089 D 661410 CDS YP_003071161.1 254564066 8194904 5744973..5745188 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 5745188 8194904 METDI5756 Methylobacterium extorquens DM4 hypothetical protein YP_003071161.1 5744973 D 661410 CDS YP_003071162.1 254564067 8194905 complement(5745157..5745519) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 5745519 8194905 METDI5757 Methylobacterium extorquens DM4 hypothetical protein YP_003071162.1 5745157 R 661410 CDS YP_003071163.1 254564068 8194906 complement(5746347..5746721) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5746721 8194906 METDI5758 Methylobacterium extorquens DM4 hypothetical protein YP_003071163.1 5746347 R 661410 CDS YP_003071164.1 254564069 8194907 complement(5746897..5747172) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 5747172 8194907 METDI5759 Methylobacterium extorquens DM4 hypothetical protein YP_003071164.1 5746897 R 661410 CDS YP_003071165.1 254564070 8194908 complement(5747200..5747454) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 5747454 8194908 METDI5760 Methylobacterium extorquens DM4 hypothetical protein YP_003071165.1 5747200 R 661410 CDS YP_003071166.1 254564071 8194909 complement(5747884..5748780) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5748780 8194909 METDI5761 Methylobacterium extorquens DM4 hypothetical protein YP_003071166.1 5747884 R 661410 CDS YP_003071167.1 254564072 8194910 5749373..5749735 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5749735 8194910 METDI5762 Methylobacterium extorquens DM4 hypothetical protein YP_003071167.1 5749373 D 661410 CDS YP_003071168.1 254564073 8194911 5749971..5750165 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 5750165 8194911 METDI5763 Methylobacterium extorquens DM4 hypothetical protein YP_003071168.1 5749971 D 661410 CDS YP_003071169.1 254564074 8194912 5751037..5751243 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 5751243 8194912 METDI5764 Methylobacterium extorquens DM4 hypothetical protein YP_003071169.1 5751037 D 661410 CDS YP_003071170.1 254564075 8194913 complement(5751284..5751559) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 5751559 8194913 METDI5765 Methylobacterium extorquens DM4 hypothetical protein YP_003071170.1 5751284 R 661410 CDS YP_003071171.1 254564076 8194914 5751979..5753019 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type t : transporter; phosphate ABC transporter, periplasmic phosphate binding protein 5753019 pstS 8194914 pstS Methylobacterium extorquens DM4 phosphate ABC transporter, periplasmic phosphate binding protein YP_003071171.1 5751979 D 661410 CDS YP_003071172.1 254564077 8195913 5753134..5754108 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type t : transporter; phosphate ABC transporter, permease 5754108 pstC 8195913 pstC Methylobacterium extorquens DM4 phosphate ABC transporter, permease YP_003071172.1 5753134 D 661410 CDS YP_003071173.1 254564078 8195912 5754153..5755046 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type t : transporter; phosphate ABC transporter, permease 5755046 pstA 8195912 pstA Methylobacterium extorquens DM4 phosphate ABC transporter, permease YP_003071173.1 5754153 D 661410 CDS YP_003071174.1 254564079 8195910 5755088..5755903 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type t : transporter; phosphate ABC transporter, ATPase 5755903 pstB 8195910 pstB Methylobacterium extorquens DM4 phosphate ABC transporter, ATPase YP_003071174.1 5755088 D 661410 CDS YP_003071175.1 254564080 8195911 5756035..5756748 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type r : regulator; phosphate transport system regulatory protein PhoU 5756748 phoU 8195911 phoU Methylobacterium extorquens DM4 phosphate transport system regulatory protein PhoU YP_003071175.1 5756035 D 661410 CDS YP_003071176.1 254564081 8195863 5756831..5757535 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 90133909, 91100346; Product type r : regulator; phosphate regulon transcriptional regulatory protein PhoB 5757535 phoB 8195863 phoB Methylobacterium extorquens DM4 phosphate regulon transcriptional regulatory protein PhoB YP_003071176.1 5756831 D 661410 CDS YP_003071177.1 254564082 8195862 complement(5757741..5758280) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5758280 8195862 METDI5772 Methylobacterium extorquens DM4 hypothetical protein YP_003071177.1 5757741 R 661410 CDS YP_003071178.1 254564083 8194915 5758792..5759658 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5759658 8194915 METDI5773 Methylobacterium extorquens DM4 hypothetical protein YP_003071178.1 5758792 D 661410 CDS YP_003071179.1 254564084 8194916 complement(5759669..5760916) 1 NC_012988.1 involved in translesion DNA polymerization with beta clamp of polymerase III; belongs to Y family of polymerases; does not contain proofreading function; DNA polymerase IV 5760916 dinB 8194916 dinB Methylobacterium extorquens DM4 DNA polymerase IV YP_003071179.1 5759669 R 661410 CDS YP_003071180.1 254564085 8195295 5761003..5761824 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 1732193, 2211521; Product type e : enzyme; Precorrin-6A reductase (Precorrin-6X reductase) 5761824 cobK 8195295 cobK Methylobacterium extorquens DM4 Precorrin-6A reductase (Precorrin-6X reductase) YP_003071180.1 5761003 D 661410 CDS YP_003071181.1 254564086 8195191 5761895..5763352 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 11743193, 11743194; Product type e : enzyme; cobyric acid synthase 5763352 cobQ1 8195191 cobQ1 Methylobacterium extorquens DM4 cobyric acid synthase YP_003071181.1 5761895 D 661410 CDS YP_003071182.1 254564087 8195195 complement(5763461..5764462) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 2211520; Product type e : enzyme; Cobalamin biosynthesis protein cobD 5764462 cobD 8195195 cobD Methylobacterium extorquens DM4 Cobalamin biosynthesis protein cobD YP_003071182.1 5763461 R 661410 CDS YP_003071183.1 254564088 8195185 5764489..5765484 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 2211520; Product type e : enzyme; Threonine-phosphate decarboxylase (L-threonine-O-3-phosphate decarboxylase) 5765484 cobC 8195185 cobC Methylobacterium extorquens DM4 Threonine-phosphate decarboxylase (L-threonine-O-3-phosphate decarboxylase) YP_003071183.1 5764489 D 661410 CDS YP_003071184.1 254564089 8195184 complement(5765477..5766661) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative Sugar efflux transporter B 5766661 8195184 METDI5779 Methylobacterium extorquens DM4 putative Sugar efflux transporter B YP_003071184.1 5765477 R 661410 CDS YP_003071185.1 254564090 8194917 5767068..5767271 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5767271 8194917 METDI5780 Methylobacterium extorquens DM4 hypothetical protein YP_003071185.1 5767068 D 661410 CDS YP_003071186.1 254564091 8194918 5767473..5768882 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 9826185; Product type e : enzyme; malonyl-CoA decarboxylase 5768882 matA 8194918 matA Methylobacterium extorquens DM4 malonyl-CoA decarboxylase YP_003071186.1 5767473 D 661410 CDS YP_003071187.1 254564092 8195662 5769019..5769375 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 11988534; hypothetical protein 5769375 8195662 METDI5782 Methylobacterium extorquens DM4 hypothetical protein YP_003071187.1 5769019 D 661410 CDS YP_003071188.1 254564093 8194919 complement(5769529..5770314) 1 NC_012988.1 Evidence 1c : Function experimentally demonstrated in the studied genus; PubMedId : 11208803, 16926146; Product type e : enzyme; D-beta-hydroxybutyrate dehydrogenase 5770314 hbd 8194919 hbd Methylobacterium extorquens DM4 D-beta-hydroxybutyrate dehydrogenase YP_003071188.1 5769529 R 661410 CDS YP_003071189.1 254564094 8195545 5770519..5771481 1 NC_012988.1 catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer composed of two alpha (AccA) and two beta (AccD) subunits; one of the two catalytic subunits that can form the acetyl CoA carboxylase enzyme together with a carrier protein; acetyl-CoA carboxylase carboxyltransferase subunit alpha 5771481 accA 8195545 accA Methylobacterium extorquens DM4 acetyl-CoA carboxylase carboxyltransferase subunit alpha YP_003071189.1 5770519 D 661410 CDS YP_003071190.1 254564095 8195044 5771478..5772191 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 5772191 8195044 METDI5785 Methylobacterium extorquens DM4 hypothetical protein YP_003071190.1 5771478 D 661410 CDS YP_003071191.1 254564096 8194920 5772339..5773727 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5773727 8194920 METDI5786 Methylobacterium extorquens DM4 hypothetical protein YP_003071191.1 5772339 D 661410 CDS YP_003071192.1 254564097 8194921 5773926..5774330 1 NC_012988.1 this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site; 50S ribosomal protein L19 5774330 rplS 8194921 rplS Methylobacterium extorquens DM4 50S ribosomal protein L19 YP_003071192.1 5773926 D 661410 CDS YP_003071193.1 254564098 8196028 5774573..5774932 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative nucleotidyltransferase domain 5774932 8196028 METDI5788 Methylobacterium extorquens DM4 putative nucleotidyltransferase domain YP_003071193.1 5774573 D 661410 CDS YP_003071194.1 254564099 8194922 5774998..5775333 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5775333 8194922 METDI5789 Methylobacterium extorquens DM4 hypothetical protein YP_003071194.1 5774998 D 661410 CDS YP_003071195.1 254564100 8194923 complement(5775364..5776560) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative membrane-bound lytic murein transglycosylase 5776560 8194923 METDI5790 Methylobacterium extorquens DM4 putative membrane-bound lytic murein transglycosylase YP_003071195.1 5775364 R 661410 CDS YP_003071196.1 254564101 8194924 5777013..5777630 1 NC_012988.1 primary rRNA binding protein; nucleates 30S assembly; involved in translational accuracy with proteins S5 and S12; interacts with protein S5; involved in autogeneously regulating ribosomal proteins by binding to pseudoknot structures in the polycistronic mRNA; interacts with transcription complex and functions similar to protein NusA in antitermination; 30S ribosomal protein S4 5777630 rpsD 8194924 rpsD Methylobacterium extorquens DM4 30S ribosomal protein S4 YP_003071196.1 5777013 D 661410 CDS YP_003071197.1 254564102 8196055 complement(5777759..5778811) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 7813473; Product type e : enzyme; 2-nitropropane dioxygenase, (nitroalkane oxidase) (2-NPD) 5778811 2-npdl 8196055 2-npdl Methylobacterium extorquens DM4 2-nitropropane dioxygenase, (nitroalkane oxidase) (2-NPD) YP_003071197.1 5777759 R 661410 CDS YP_003071198.1 254564103 8195041 complement(5778913..5779755) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 14996797; Product type e : enzyme; phosphatidylserine synthase (pssA-like) 5779755 pssA 8195041 pssA Methylobacterium extorquens DM4 phosphatidylserine synthase (pssA-like) YP_003071198.1 5778913 R 661410 CDS YP_003071199.1 254564104 8195909 complement(5779830..5780540) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; phosphatidylserine decarboxylase (psd-like) 5780540 psd 8195909 psd Methylobacterium extorquens DM4 phosphatidylserine decarboxylase (psd-like) YP_003071199.1 5779830 R 661410 CDS YP_003071200.1 254564105 8195908 complement(5780616..5782607) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative ABC transporter, fused ATPase and permease domains 5782607 8195908 METDI5795 Methylobacterium extorquens DM4 putative ABC transporter, fused ATPase and permease domains YP_003071200.1 5780616 R 661410 CDS YP_003071201.1 254564106 8194925 complement(5782666..5784201) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure; putative peptidoglycan-binding precursor LysM 5784201 8194925 METDI5796 Methylobacterium extorquens DM4 putative peptidoglycan-binding precursor LysM YP_003071201.1 5782666 R 661410 CDS YP_003071202.1 254564107 8194926 5784418..5785020 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5785020 8194926 METDI5797 Methylobacterium extorquens DM4 hypothetical protein YP_003071202.1 5784418 D 661410 CDS YP_003071203.1 254564108 8194927 5785020..5785811 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 5785811 8194927 METDI5798 Methylobacterium extorquens DM4 hypothetical protein YP_003071203.1 5785020 D 661410 CDS YP_003071204.1 254564109 8194928 complement(5785866..5787254) 1 NC_012988.1 catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA; cysteinyl-tRNA synthetase 5787254 cysS 8194928 cysS Methylobacterium extorquens DM4 cysteinyl-tRNA synthetase YP_003071204.1 5785866 R 661410 CDS YP_003071205.1 254564110 8195261 5787583..5787906 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5787906 8195261 METDI5800 Methylobacterium extorquens DM4 hypothetical protein YP_003071205.1 5787583 D 661410 CDS YP_003071206.1 254564111 8194929 complement(5787920..5788474) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5788474 8194929 METDI5801 Methylobacterium extorquens DM4 hypothetical protein YP_003071206.1 5787920 R 661410 CDS YP_003071207.1 254564112 8194930 5788548..5789648 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 5789648 8194930 METDI5802 Methylobacterium extorquens DM4 hypothetical protein YP_003071207.1 5788548 D 661410 CDS YP_003071208.1 254564113 8194931 5789812..5791965 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5791965 8194931 METDI5803 Methylobacterium extorquens DM4 hypothetical protein YP_003071208.1 5789812 D 661410 CDS YP_003071209.1 254564114 8194932 5792139..5793353 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type t : transporter; Inner membrane transport protein ynfM 5793353 ynfM 8194932 ynfM Methylobacterium extorquens DM4 Inner membrane transport protein ynfM YP_003071209.1 5792139 D 661410 CDS YP_003071210.1 254564115 8196376 5793440..5793931 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative 3-demethylubiquinone-9 3-methyltransferase 5793931 8196376 METDI5805 Methylobacterium extorquens DM4 putative 3-demethylubiquinone-9 3-methyltransferase YP_003071210.1 5793440 D 661410 CDS YP_003071211.1 254564116 8194933 5793928..5794707 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative S-adenosyl-L-methionine-dependent methyltransferase 5794707 yafE 8194933 yafE Methylobacterium extorquens DM4 putative S-adenosyl-L-methionine-dependent methyltransferase YP_003071211.1 5793928 D 661410 CDS YP_003071212.1 254564117 8196347 complement(5794704..5796053) 1 NC_012988.1 Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation; glutamyl-tRNA synthetase 5796053 gltX 8196347 gltX Methylobacterium extorquens DM4 glutamyl-tRNA synthetase YP_003071212.1 5794704 R 661410 CDS YP_003071213.1 254564118 8195518 complement(5796110..5797189) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; putative efflux pump component 5797189 8195518 METDI5808 Methylobacterium extorquens DM4 putative efflux pump component YP_003071213.1 5796110 R 661410 CDS YP_003071214.1 254564119 8194934 complement(5797186..5797380) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5797380 8194934 METDI5809 Methylobacterium extorquens DM4 hypothetical protein YP_003071214.1 5797186 R 661410 CDS YP_003071215.1 254564120 8194935 complement(5797389..5799425) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative membrane protein; putative efflux transporter protein 5799425 8194935 METDI5810 Methylobacterium extorquens DM4 putative membrane protein; putative efflux transporter protein YP_003071215.1 5797389 R 661410 CDS YP_003071216.1 254564121 8194936 complement(5799422..5799856) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5799856 8194936 METDI5811 Methylobacterium extorquens DM4 hypothetical protein YP_003071216.1 5799422 R 661410 CDS YP_003071217.1 254564122 8194937 complement(5800019..5800300) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 5800300 8194937 METDI5812 Methylobacterium extorquens DM4 hypothetical protein YP_003071217.1 5800019 R 661410 CDS YP_003071218.1 254564123 8194938 5800627..5801295 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative glutathione S-transferase 5801295 8194938 METDI5813 Methylobacterium extorquens DM4 putative glutathione S-transferase YP_003071218.1 5800627 D 661410 CDS YP_003071219.1 254564124 8194939 complement(5802195..5803535) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 10673426, 10735848, 8955385; Product type t : transporter; protein tolB precursor 5803535 tolB 8194939 tolB Methylobacterium extorquens DM4 protein tolB precursor YP_003071219.1 5802195 R 661410 CDS YP_003071220.1 254564125 8196204 complement(5803614..5805029) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 10404600, 2068069, 2687247, 8905232, 8978668; Product type m : membrane component; TolA-TolQ-TolR complex membrane anchor protein 5805029 tolA 8196204 tolA Methylobacterium extorquens DM4 TolA-TolQ-TolR complex membrane anchor protein YP_003071220.1 5803614 R 661410 CDS YP_003071221.1 254564126 8196203 complement(5805044..5805493) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 1644779, 2670903, 88273230, 93302502, 8063379; Product type m : membrane component; biopolymer transport protein ExbD/TolR 5805493 8196203 METDI5817 Methylobacterium extorquens DM4 biopolymer transport protein ExbD/TolR YP_003071221.1 5805044 R 661410 CDS YP_003071222.1 254564127 8194940 complement(5805543..5806259) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type m : membrane component; membrane spanning protein in TolA-TolQ-TolR complex 5806259 tolQ 8194940 tolQ Methylobacterium extorquens DM4 membrane spanning protein in TolA-TolQ-TolR complex YP_003071222.1 5805543 R 661410 CDS YP_003071223.1 254564128 8196205 5806699..5807949 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 12029363, 7708770; hypothetical protein 5807949 8196205 METDI5819 Methylobacterium extorquens DM4 hypothetical protein YP_003071223.1 5806699 D 661410 CDS YP_003071224.1 254564129 8194941 complement(5807936..5808373) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 10493123, 11959124, 15808744, 16294310, 3294803; Product type e : enzyme; acyl-CoA thioesterase 5808373 ybgC 8194941 ybgC Methylobacterium extorquens DM4 acyl-CoA thioesterase YP_003071224.1 5807936 R 661410 CDS YP_003071225.1 254564130 8196350 complement(5808538..5809254) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5809254 8196350 METDI5821 Methylobacterium extorquens DM4 hypothetical protein YP_003071225.1 5808538 R 661410 CDS YP_003071226.1 254564131 8194942 complement(5809693..5810763) 1 NC_012988.1 promotes strand exchange during homologous recombination; RuvAB complex promotes branch migration; RuvABC complex scans the DNA during branch migration and resolves Holliday junctions at consensus sequences; forms hexameric rings around opposite DNA arms; requires ATP for branch migration and orientation of RuvAB complex determines direction of migration; Holliday junction DNA helicase RuvB 5810763 ruvB 8194942 ruvB Methylobacterium extorquens DM4 Holliday junction DNA helicase RuvB YP_003071226.1 5809693 R 661410 CDS YP_003071227.1 254564132 8196096 5811219..5812979 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative peptidoglycan-binding protein (N-terminal domain) 5812979 8196096 METDI5824 Methylobacterium extorquens DM4 putative peptidoglycan-binding protein (N-terminal domain) YP_003071227.1 5811219 D 661410 CDS YP_003071228.1 254564133 8194943 5813125..5813652 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 10966408, 16926146; Product type pf : putative factor; Dps protein family starvation-inducible DNA-binding protein 5813652 8194943 METDI5825 Methylobacterium extorquens DM4 Dps protein family starvation-inducible DNA-binding protein YP_003071228.1 5813125 D 661410 CDS YP_003071229.1 254564134 8194944 complement(5813738..5816440) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5816440 8194944 METDI5826 Methylobacterium extorquens DM4 hypothetical protein YP_003071229.1 5813738 R 661410 CDS YP_003071230.1 254564135 8194945 5816785..5817435 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 10821675, 11054289, 15299567; Product type e : enzyme; L-fuculose-1-phosphate aldolase 5817435 fucA 8194945 fucA Methylobacterium extorquens DM4 L-fuculose-1-phosphate aldolase YP_003071230.1 5816785 D 661410 CDS YP_003071231.1 254564136 8195458 complement(5817614..5817811) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 5817811 8195458 METDI5828 Methylobacterium extorquens DM4 hypothetical protein YP_003071231.1 5817614 R 661410 CDS YP_003071232.1 254564137 8194946 5818030..5818557 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 10656595, 11481430, 7756693; Product type r : regulator; transcriptional regulator (RosR/MucR family) 5818557 8194946 METDI5829 Methylobacterium extorquens DM4 transcriptional regulator (RosR/MucR family) YP_003071232.1 5818030 D 661410 CDS YP_003071233.1 254564138 8194947 5818777..5819559 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 5819559 8194947 METDI5831 Methylobacterium extorquens DM4 hypothetical protein YP_003071233.1 5818777 D 661410 CDS YP_003071234.1 254564139 8194948 complement(5819562..5820863) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 5820863 8194948 METDI5832 Methylobacterium extorquens DM4 hypothetical protein YP_003071234.1 5819562 R 661410 CDS YP_003071235.1 254564140 8194949 5821342..5823525 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 8335642; Product type e : enzyme; penicillin-binding protein 5823525 pbpC 8194949 pbpC Methylobacterium extorquens DM4 penicillin-binding protein YP_003071235.1 5821342 D 661410 CDS YP_003071236.1 254564141 8195831 5823649..5824887 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 7750735; Product type pe : putative enzyme; putative transmembrane adenylate/guanylate cyclase 5824887 8195831 METDI5834 Methylobacterium extorquens DM4 putative transmembrane adenylate/guanylate cyclase YP_003071236.1 5823649 D 661410 CDS YP_003071237.1 254564142 8194950 complement(5824906..5825304) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative Glutathione S-transferase related protein, MAPEG superfamily 5825304 8194950 METDI5835 Methylobacterium extorquens DM4 putative Glutathione S-transferase related protein, MAPEG superfamily YP_003071237.1 5824906 R 661410 CDS YP_003071238.1 254564143 8194951 5825601..5826506 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative cobyrinic acid a,c-diamide synthase 5826506 8194951 METDI5836 Methylobacterium extorquens DM4 putative cobyrinic acid a,c-diamide synthase YP_003071238.1 5825601 D 661410 CDS YP_003071239.1 254564144 8194952 5826496..5827020 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5827020 8194952 METDI5837 Methylobacterium extorquens DM4 hypothetical protein YP_003071239.1 5826496 D 661410 CDS YP_003071240.1 254564145 8194953 complement(5827045..5827389) 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 5827389 8194953 METDI5838 Methylobacterium extorquens DM4 hypothetical protein YP_003071240.1 5827045 R 661410 CDS YP_003071241.1 254564146 8194954 complement(5827525..5829165) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type f : factor; 60 kDa chaperonin (protein Cpn60, groEL protein) 5829165 groL 8194954 groL Methylobacterium extorquens DM4 60 kDa chaperonin (protein Cpn60, groEL protein) YP_003071241.1 5827525 R 661410 CDS YP_003071242.1 254564147 8195533 complement(5829258..5829548) 1 NC_012988.1 10 kDa chaperonin; Cpn10; GroES; forms homoheptameric ring; binds to one or both ends of the GroEL double barrel in the presence of adenine nucleotides capping it; folding of unfolded substrates initiates in a GroEL-substrate bound and capped by GroES; release of the folded substrate is dependent on ATP binding and hydrolysis in the trans ring; co-chaperonin GroES 5829548 groES 8195533 groES Methylobacterium extorquens DM4 co-chaperonin GroES YP_003071242.1 5829258 R 661410 CDS YP_003071243.1 254564148 8195535 5829763..5830767 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative magnesium/cobalt transport protein 5830767 8195535 METDI5841 Methylobacterium extorquens DM4 putative magnesium/cobalt transport protein YP_003071243.1 5829763 D 661410 CDS YP_003071244.1 254564149 8194955 complement(5830810..5831451) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative multiple antibiotic resistance protein, MarC family transport protein 5831451 8194955 METDI5842 Methylobacterium extorquens DM4 putative multiple antibiotic resistance protein, MarC family transport protein YP_003071244.1 5830810 R 661410 CDS YP_003071245.1 254564150 8194956 5831628..5833088 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5833088 8194956 METDI5843 Methylobacterium extorquens DM4 hypothetical protein YP_003071245.1 5831628 D 661410 CDS YP_003071246.1 254564151 8194957 5833220..5834410 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8606183, 96178972; Product type pe : putative enzyme; putative glycolate oxidase subunit GlcE 5834410 8194957 METDI5844 Methylobacterium extorquens DM4 putative glycolate oxidase subunit GlcE YP_003071246.1 5833220 D 661410 CDS YP_003071247.1 254564152 8194958 complement(5834424..5836064) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type t : transporter; low-affinity phosphate transport protein (PiT family) 5836064 pitA 8194958 pitA Methylobacterium extorquens DM4 low-affinity phosphate transport protein (PiT family) YP_003071247.1 5834424 R 661410 CDS YP_003071248.1 254564153 8195866 5836391..5836600 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 5836600 8195866 METDI5846 Methylobacterium extorquens DM4 hypothetical protein YP_003071248.1 5836391 D 661410 CDS YP_003071249.1 254564154 8194959 5836700..5836885 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 5836885 8194959 METDI5847 Methylobacterium extorquens DM4 hypothetical protein YP_003071249.1 5836700 D 661410 CDS YP_003071250.1 254564155 8194960 5836894..5837196 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5837196 8194960 METDI5848 Methylobacterium extorquens DM4 hypothetical protein YP_003071250.1 5836894 D 661410 CDS YP_003071251.1 254564156 8194961 5837193..5838710 1 NC_012988.1 in Escherichia coli this homodimeric enzyme is expressed under aerobic conditions; anaerobic expression is repressed by the arcAB system; converts sn-glycerol-3-phosphate and ubiquinone-8 to dihydroxy acetone phosphate and ubiquinol-8; associates with the cytoplasmic membrane; glycerol-3-phosphate dehydrogenase 5838710 glpD 8194961 glpD Methylobacterium extorquens DM4 glycerol-3-phosphate dehydrogenase YP_003071251.1 5837193 D 661410 CDS YP_003071252.1 254564157 8195507 complement(5838698..5840131) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 1846611; Product type e : enzyme; Mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase 5840131 algA 8195507 algA Methylobacterium extorquens DM4 Mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase YP_003071252.1 5838698 R 661410 CDS YP_003071253.1 254564158 8195069 complement(5840325..5842490) 1 NC_012988.1 MDM; functions in conversion of succinate to propionate; methylmalonyl-CoA mutase 5842490 mcmA 8195069 mcmA Methylobacterium extorquens DM4 methylmalonyl-CoA mutase YP_003071253.1 5840325 R 661410 CDS YP_003071254.1 254564159 8195668 complement(5842596..5843096) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 5843096 8195668 METDI5852 Methylobacterium extorquens DM4 hypothetical protein YP_003071254.1 5842596 R 661410 CDS YP_003071255.1 254564160 8194962 5843212..5844141 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5844141 8194962 METDI5853 Methylobacterium extorquens DM4 hypothetical protein YP_003071255.1 5843212 D 661410 CDS YP_003071256.1 254564161 8194963 complement(5844134..5844349) 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 5844349 8194963 METDI5854 Methylobacterium extorquens DM4 hypothetical protein YP_003071256.1 5844134 R 661410 CDS YP_003071257.1 254564162 8194964 5844867..5846012 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; serine protease 5846012 8194964 METDI5855 Methylobacterium extorquens DM4 serine protease YP_003071257.1 5844867 D 661410 CDS YP_003071258.1 254564163 8194965 5846082..5846777 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5846777 8194965 METDI5856 Methylobacterium extorquens DM4 hypothetical protein YP_003071258.1 5846082 D 661410 CDS YP_003071259.1 254564164 8194966 complement(5847007..5848491) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative D-alanyl-D-alanine carboxypeptidase 5848491 8194966 METDI5857 Methylobacterium extorquens DM4 putative D-alanyl-D-alanine carboxypeptidase YP_003071259.1 5847007 R 661410 CDS YP_003071260.1 254564165 8194967 5848982..5849320 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 11931773, 12576022; Product type r : regulator; ATP-dependent Clp protease adaptor protein clpS 5849320 clpS 8194967 clpS Methylobacterium extorquens DM4 ATP-dependent Clp protease adaptor protein clpS YP_003071260.1 5848982 D 661410 CDS YP_003071261.1 254564166 8195173 5849343..5851826 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 12205096, 122351, 21243159, 21369885, 2185473, 90243657, 9573050, 9575205; Product type e : enzyme; ATPase and specificity subunit of ClpA-ClpP ATP-dependent serine protease, chaperone activity 5851826 clpA 8195173 clpA Methylobacterium extorquens DM4 ATPase and specificity subunit of ClpA-ClpP ATP-dependent serine protease, chaperone activity YP_003071261.1 5849343 D 661410 CDS YP_003071262.1 254564167 8195168 5851962..5852234 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 5852234 8195168 METDI5860 Methylobacterium extorquens DM4 hypothetical protein YP_003071262.1 5851962 D 661410 CDS YP_003071263.1 254564168 8194968 complement(5852247..5853464) 1 NC_012988.1 catalyzes the formation of 5-aminolevulinate from succinyl-CoA and glycine; 5-aminolevulinate synthase 5853464 hemA 8194968 hemA Methylobacterium extorquens DM4 5-aminolevulinate synthase YP_003071263.1 5852247 R 661410 CDS YP_003071264.1 254564169 8195548 complement(5853520..5854329) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5854329 8195548 METDI5862 Methylobacterium extorquens DM4 hypothetical protein YP_003071264.1 5853520 R 661410 CDS YP_003071265.1 254564170 8194969 complement(5854331..5855425) 1 NC_012988.1 oxidative; catalyzes the formation of divinylprotochlorophyllide from magnesium-protoporphyrin IX 13-monomethyl ester in isocyclic ring formation in chlorophyll biosynthesis; magnesium-protoporphyrin IX monomethyl ester cyclase 5855425 acsF 8194969 acsF Methylobacterium extorquens DM4 magnesium-protoporphyrin IX monomethyl ester cyclase YP_003071265.1 5854331 R 661410 CDS YP_003071266.1 254564171 8195058 complement(5855422..5855718) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5855718 8195058 METDI5864 Methylobacterium extorquens DM4 hypothetical protein YP_003071266.1 5855422 R 661410 CDS YP_003071267.1 254564172 8194970 complement(5855748..5856218) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5856218 8194970 METDI5865 Methylobacterium extorquens DM4 hypothetical protein YP_003071267.1 5855748 R 661410 CDS YP_003071268.1 254564173 8194971 complement(5856234..5856938) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5856938 8194971 METDI5866 Methylobacterium extorquens DM4 hypothetical protein YP_003071268.1 5856234 R 661410 CDS YP_003071269.1 254564174 8194972 complement(5856950..5857723) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type m : membrane component; photosynthetic reaction center subunit H 5857723 puhA 8194972 puhA Methylobacterium extorquens DM4 photosynthetic reaction center subunit H YP_003071269.1 5856950 R 661410 CDS YP_003071270.1 254564175 8195928 complement(5857738..5859183) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type t : transporter; photosynthetic complex (LH1) assembly protein LhaA, Major Facilitator Superfamily (MFS) transporter 5859183 lhaA 8195928 lhaA Methylobacterium extorquens DM4 photosynthetic complex (LH1) assembly protein LhaA, Major Facilitator Superfamily (MFS) transporter YP_003071270.1 5857738 R 661410 CDS YP_003071271.1 254564176 8195635 complement(5859180..5859911) 1 NC_012988.1 catalyzes the formation of Mg-protoporphyrin IX methyl ester and S-adenosyl-L-homocysteine from Mg-protoporphyrin IX and S-adenosyl-L-methionine; Mg-protoporphyrin IX methyl transferase 5859911 bchM 8195635 bchM Methylobacterium extorquens DM4 Mg-protoporphyrin IX methyl transferase YP_003071271.1 5859180 R 661410 CDS YP_003071272.1 254564177 8195134 complement(5859911..5860804) 1 NC_012988.1 light-independent; with chlN(bchN) and chlB(bchB) reduces ring D of protochlorophyllide to form chlorophyllide a in chlorophyll/bacteriochlorophyll production; protochlorophyllide reductase iron-sulfur ATP-binding protein 5860804 chlL 8195134 chlL Methylobacterium extorquens DM4 protochlorophyllide reductase iron-sulfur ATP-binding protein YP_003071272.1 5859911 R 661410 CDS YP_003071273.1 254564178 8195133 complement(5860801..5864517) 1 NC_012988.1 involved in chelation of magnesium into protoporphyrin IX; involved in bacteriochlorophyll biosynthesis; the enzyme from Rhodobacter capsulatus contains an Fe-S cluster; part of a complex with BchI, BchD, and BchH; magnesium chelatase subunit H 5864517 bchH 8195133 bchH Methylobacterium extorquens DM4 magnesium chelatase subunit H YP_003071273.1 5860801 R 661410 CDS YP_003071274.1 254564179 8195131 complement(5864492..5866087) 1 NC_012988.1 light-independent reduction of protochlorophyllide to form chlorophyllide a; light-independent protochlorophyllide reductase subunit B 5866087 bchB 8195131 bchB Methylobacterium extorquens DM4 light-independent protochlorophyllide reductase subunit B YP_003071274.1 5864492 R 661410 CDS YP_003071275.1 254564180 8195125 complement(5866093..5867361) 1 NC_012988.1 light-independent reduction of protochlorophyllide to form chlorophyllide a; light-independent protochlorophyllide reductase subunit N 5867361 bchN 8195125 bchN Methylobacterium extorquens DM4 light-independent protochlorophyllide reductase subunit N YP_003071275.1 5866093 R 661410 CDS YP_003071276.1 254564181 8195135 complement(5867358..5867861) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 8385667; Product type e : enzyme; 2-vinyl bacteriochlorophyllide hydratase 5867861 bchF 8195135 bchF Methylobacterium extorquens DM4 2-vinyl bacteriochlorophyllide hydratase YP_003071276.1 5867358 R 661410 CDS YP_003071277.1 254564182 8195129 5868118..5869005 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5869005 8195129 METDI5875 Methylobacterium extorquens DM4 hypothetical protein YP_003071277.1 5868118 D 661410 CDS YP_003071278.1 254564183 8194973 5869033..5870493 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type r : regulator; transcriptional regulator PpsR-CrtJ; Fis family 5870493 ppsR 8194973 ppsR Methylobacterium extorquens DM4 transcriptional regulator PpsR-CrtJ; Fis family YP_003071278.1 5869033 D 661410 CDS YP_003071279.1 254564184 8195886 5870616..5871503 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; bacteriochlorophyll/chlorophyll a synthase 5871503 bchG 8195886 bchG Methylobacterium extorquens DM4 bacteriochlorophyll/chlorophyll a synthase YP_003071279.1 5870616 D 661410 CDS YP_003071280.1 254564185 8195130 5871500..5872879 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type t : transporter; light harvesting pigment Major Facilitator Family (MFS) transporter, (Bch2-like) 5872879 pucC 8195130 pucC Methylobacterium extorquens DM4 light harvesting pigment Major Facilitator Family (MFS) transporter, (Bch2-like) YP_003071280.1 5871500 D 661410 CDS YP_003071281.1 254564186 8195922 5872884..5874077 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; geranylgeranyl reductase 5874077 bchP 8195922 bchP Methylobacterium extorquens DM4 geranylgeranyl reductase YP_003071281.1 5872884 D 661410 CDS YP_003071282.1 254564187 8195136 5874074..5874583 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 11097914, 7673149; Product type m : membrane component; tryptophan-rich sensory membrane protein precursor (CrtK homolog); putative regulatory receptor protein 5874583 8195136 METDI5880 Methylobacterium extorquens DM4 tryptophan-rich sensory membrane protein precursor (CrtK homolog); putative regulatory receptor protein YP_003071282.1 5874074 D 661410 CDS YP_003071283.1 254564188 8194974 5874587..5874952 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5874952 8194974 METDI5881 Methylobacterium extorquens DM4 hypothetical protein YP_003071283.1 5874587 D 661410 CDS YP_003071284.1 254564189 8194975 5874996..5876591 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 9352901; Product type pc : putative carrier; putative cytochrome c, putative exported protein 5876591 8194975 METDI5882 Methylobacterium extorquens DM4 putative cytochrome c, putative exported protein YP_003071284.1 5874996 D 661410 CDS YP_003071285.1 254564190 8194976 5876766..5877758 1 NC_012988.1 similar to full-length Gnd, these proteins seems to have a truncated C-terminal 6PGD domainin; in Methylobacillus flagellatus this gene is essential for NAD+-dependent oxidation of 6-phosphogluconate; 6-phosphogluconate dehydrogenase-like protein 5877758 gnd 8194976 gnd Methylobacterium extorquens DM4 6-phosphogluconate dehydrogenase-like protein YP_003071285.1 5876766 D 661410 CDS YP_003071286.1 254564191 8195524 5877755..5878486 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 10518023; Product type e : enzyme; 6-phosphogluconolactonase 5878486 pgl 8195524 pgl Methylobacterium extorquens DM4 6-phosphogluconolactonase YP_003071286.1 5877755 D 661410 CDS YP_003071287.1 254564192 8195850 5878599..5879165 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5879165 8195850 METDI5885 Methylobacterium extorquens DM4 hypothetical protein YP_003071287.1 5878599 D 661410 CDS YP_003071288.1 254564193 8194977 complement(5879278..5881050) 1 NC_012988.1 responsible for transport of beta-1,2-glucans from the cytoplasm to periplasm; inner membrane ABC transporter permease component; Cgt; ChvA; NdvA; cyclic beta-1,2-glucan ABC transporter 5881050 8194977 METDI5886 Methylobacterium extorquens DM4 cyclic beta-1,2-glucan ABC transporter YP_003071288.1 5879278 R 661410 CDS YP_003071289.1 254564194 8194978 5881321..5882094 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type f : factor; putative chemotaxis protein (flagellar motor component) 5882094 8194978 METDI5887 Methylobacterium extorquens DM4 putative chemotaxis protein (flagellar motor component) YP_003071289.1 5881321 D 661410 CDS YP_003071290.1 254564195 8194979 5882109..5882942 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type prc : putative receptor; putative chemotaxis protein MotB 5882942 8194979 METDI5888 Methylobacterium extorquens DM4 putative chemotaxis protein MotB YP_003071290.1 5882109 D 661410 CDS YP_003071291.1 254564196 8194980 complement(5882964..5883392) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5883392 8194980 METDI5889 Methylobacterium extorquens DM4 hypothetical protein YP_003071291.1 5882964 R 661410 CDS YP_003071292.1 254564197 8194981 complement(5883595..5886288) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5886288 8194981 METDI5890 Methylobacterium extorquens DM4 hypothetical protein YP_003071292.1 5883595 R 661410 CDS YP_003071293.1 254564198 8194982 5887036..5887584 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative endonuclease 5887584 8194982 METDI5891 Methylobacterium extorquens DM4 putative endonuclease YP_003071293.1 5887036 D 661410 CDS YP_003071294.1 254564199 8194983 complement(5887592..5887849) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 5887849 8194983 METDI5892 Methylobacterium extorquens DM4 hypothetical protein YP_003071294.1 5887592 R 661410 CDS YP_003071295.1 254564200 8194984 complement(5887876..5888775) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8751924; Product type pm : putative membrane component; putative outer-membrane immunogenic protein precursor 5888775 8194984 METDI5893 Methylobacterium extorquens DM4 putative outer-membrane immunogenic protein precursor YP_003071295.1 5887876 R 661410 CDS YP_003071296.1 254564201 8194985 complement(5889013..5889870) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5889870 8194985 METDI5894 Methylobacterium extorquens DM4 hypothetical protein YP_003071296.1 5889013 R 661410 CDS YP_003071297.1 254564202 8194986 complement(5890051..5890914) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5890914 8194986 METDI5895 Methylobacterium extorquens DM4 hypothetical protein YP_003071297.1 5890051 R 661410 CDS YP_003071298.1 254564203 8194987 complement(5891192..5892532) 1 NC_012988.1 catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; phosphoglucosamine mutase 5892532 glmM 8194987 glmM Methylobacterium extorquens DM4 phosphoglucosamine mutase YP_003071298.1 5891192 R 661410 CDS YP_003071299.1 254564204 8195494 complement(5892718..5893467) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; putative inner membrane protein 5893467 8195494 METDI5897 Methylobacterium extorquens DM4 putative inner membrane protein YP_003071299.1 5892718 R 661410 CDS YP_003071300.1 254564205 8194988 complement(5893583..5895511) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type e : enzyme; cell division protease; ATP-dependent metalloprotease 5895511 ftsH 8194988 ftsH Methylobacterium extorquens DM4 cell division protease; ATP-dependent metalloprotease YP_003071300.1 5893583 R 661410 CDS YP_003071301.1 254564206 8195451 complement(5895649..5896677) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 10572147; Product type e : enzyme; tRNA(Ile)-lysidine synthase (tRNA(Ile)-lysidine synthetase, tRNA(Ile)-2-lysyl-cytidine synthase); YaeN protein 5896677 tilS 8195451 tilS Methylobacterium extorquens DM4 tRNA(Ile)-lysidine synthase (tRNA(Ile)-lysidine synthetase, tRNA(Ile)-2-lysyl-cytidine synthase); YaeN protein YP_003071301.1 5895649 R 661410 CDS YP_003071302.1 254564207 8196198 complement(5896674..5897699) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5897699 8196198 METDI5900 Methylobacterium extorquens DM4 hypothetical protein YP_003071302.1 5896674 R 661410 CDS YP_003071303.1 254564208 8194989 complement(5897873..5898385) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 10456959; Product type m : membrane component; Outer membrane lipoprotein omp16 precursor 5898385 omp16 8194989 omp16 Methylobacterium extorquens DM4 Outer membrane lipoprotein omp16 precursor YP_003071303.1 5897873 R 661410 CDS YP_003071304.1 254564209 8195805 complement(5898770..5899123) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 5899123 8195805 METDI5902 Methylobacterium extorquens DM4 hypothetical protein YP_003071304.1 5898770 R 661410 CDS YP_003071305.1 254564210 8194990 5899226..5899624 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative reponse regulator (cheY-like protein) 5899624 8194990 METDI5903 Methylobacterium extorquens DM4 putative reponse regulator (cheY-like protein) YP_003071305.1 5899226 D 661410 CDS YP_003071306.1 254564211 8194991 complement(5899713..5900735) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 5900735 8194991 METDI5904 Methylobacterium extorquens DM4 hypothetical protein YP_003071306.1 5899713 R 661410 CDS YP_003071307.1 254564212 8194992 5900783..5901844 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5901844 8194992 METDI5905 Methylobacterium extorquens DM4 hypothetical protein YP_003071307.1 5900783 D 661410 CDS YP_003071308.1 254564213 8194993 complement(5901991..5902875) 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 11872720, 7784514; Product type e : enzyme; Porphobilinogen deaminase (PBG) (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase) 5902875 hemC 8194993 hemC Methylobacterium extorquens DM4 Porphobilinogen deaminase (PBG) (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase) YP_003071308.1 5901991 R 661410 CDS YP_003071309.1 254564214 8196238 complement(5903653..5905269) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16169924; Product type pe : putative enzyme; putative gamma-glutamyltranspeptidase 5905269 8196238 METDI5907 Methylobacterium extorquens DM4 putative gamma-glutamyltranspeptidase YP_003071309.1 5903653 R 661410 CDS YP_003071310.1 254564215 8194994 complement(5905443..5906381) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5906381 8194994 METDI5908 Methylobacterium extorquens DM4 hypothetical protein YP_003071310.1 5905443 R 661410 CDS YP_003071311.1 254564216 8194995 complement(5906378..5908849) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative ABC transporter, putative membrane protein precursor with two ATP-binding domains 5908849 8194995 METDI5909 Methylobacterium extorquens DM4 putative ABC transporter, putative membrane protein precursor with two ATP-binding domains YP_003071311.1 5906378 R 661410 CDS YP_003071312.1 254564217 8194996 complement(5908852..5909721) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative ABC transporter, permease precursor 5909721 8194996 METDI5910 Methylobacterium extorquens DM4 putative ABC transporter, permease precursor YP_003071312.1 5908852 R 661410 CDS YP_003071313.1 254564218 8194997 complement(5909768..5910958) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative ABC transporter, periplasmic protein 5910958 8194997 METDI5911 Methylobacterium extorquens DM4 putative ABC transporter, periplasmic protein YP_003071313.1 5909768 R 661410 CDS YP_003071314.1 254564219 8194998 5911169..5911579 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5911579 8194998 METDI5912 Methylobacterium extorquens DM4 hypothetical protein YP_003071314.1 5911169 D 661410 CDS YP_003071315.1 254564220 8194999 complement(5911584..5912183) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type r : regulator; Transcriptional regulator, GntR family 5912183 8194999 METDI5913 Methylobacterium extorquens DM4 Transcriptional regulator, GntR family YP_003071315.1 5911584 R 661410 CDS YP_003071316.1 254564221 8195000 complement(5912718..5913173) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 5913173 8195000 METDI5914 Methylobacterium extorquens DM4 hypothetical protein YP_003071316.1 5912718 R 661410 CDS YP_003071317.1 254564222 8195001 5914123..5914503 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 5914503 8195001 METDI5915 Methylobacterium extorquens DM4 hypothetical protein YP_003071317.1 5914123 D 661410 CDS YP_003071318.1 254564223 8195002 complement(5914578..5915594) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 5915594 8195002 METDI5916 Methylobacterium extorquens DM4 hypothetical protein YP_003071318.1 5914578 R 661410 CDS YP_003071319.1 254564224 8195003 complement(5915719..5916048) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; PubMedId : 8102363; hypothetical protein 5916048 8195003 METDI5917 Methylobacterium extorquens DM4 hypothetical protein YP_003071319.1 5915719 R 661410 CDS YP_003071320.1 254564225 8195004 complement(5915990..5917324) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative tartrate transporter ttuB 5917324 8195004 METDI5918 Methylobacterium extorquens DM4 putative tartrate transporter ttuB YP_003071320.1 5915990 R 661410 CDS YP_003071321.1 254564226 8195005 5917606..5918109 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 15188393, 16926146; hypothetical protein 5918109 8195005 METDI5919 Methylobacterium extorquens DM4 hypothetical protein YP_003071321.1 5917606 D 661410 CDS YP_003071322.1 254564227 8195006 5918298..5919791 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5919791 8195006 METDI5920 Methylobacterium extorquens DM4 hypothetical protein YP_003071322.1 5918298 D 661410 CDS YP_003071323.1 254564228 8195007 5919949..5920302 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 5920302 8195007 METDI5921 Methylobacterium extorquens DM4 hypothetical protein YP_003071323.1 5919949 D 661410 CDS YP_003071324.1 254564229 8195008 5920456..5922231 1 NC_012988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 3891724, 6308579, 89155476, 92380929, 9298646; Product type e : enzyme; acetolactate synthase III, large subunit 5922231 ilvI 8195008 ilvI Methylobacterium extorquens DM4 acetolactate synthase III, large subunit YP_003071324.1 5920456 D 661410 CDS YP_003071325.1 254564230 8195596 complement(5922292..5923203) 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5923203 8195596 METDI5923 Methylobacterium extorquens DM4 hypothetical protein YP_003071325.1 5922292 R 661410 CDS YP_003071326.1 254564231 8195009 5923310..5923852 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; acetolactate synthase III, small subunit 5923852 ilvH 8195009 ilvH Methylobacterium extorquens DM4 acetolactate synthase III, small subunit YP_003071326.1 5923310 D 661410 CDS YP_003071327.1 254564232 8195595 5923915..5924559 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative glutathione S-transferase 5924559 8195595 METDI5925 Methylobacterium extorquens DM4 putative glutathione S-transferase YP_003071327.1 5923915 D 661410 CDS YP_003071328.1 254564233 8195010 5924785..5926554 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10498721; Product type pe : putative enzyme; putative asparagine synthase, glutamine-hydrolyzing 5926554 8195010 METDI5926 Methylobacterium extorquens DM4 putative asparagine synthase, glutamine-hydrolyzing YP_003071328.1 5924785 D 661410 CDS YP_003071329.1 254564234 8195011 5926710..5927549 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative aminohydrolase/amidotransferase 5927549 8195011 METDI5927 Methylobacterium extorquens DM4 putative aminohydrolase/amidotransferase YP_003071329.1 5926710 D 661410 CDS YP_003071330.1 254564235 8195012 complement(5927692..5928438) 1 NC_012988.1 Evidence 2b : Function of strongly homologous gene; Product type f : factor; RNA polymerase sigma factor 5928438 8195012 METDI5928 Methylobacterium extorquens DM4 RNA polymerase sigma factor YP_003071330.1 5927692 R 661410 CDS YP_003071331.1 254564236 8195013 5928726..5930687 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5930687 8195013 METDI5929 Methylobacterium extorquens DM4 hypothetical protein YP_003071331.1 5928726 D 661410 CDS YP_003071332.1 254564237 8195014 5930842..5931108 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 5931108 8195014 METDI5930 Methylobacterium extorquens DM4 hypothetical protein YP_003071332.1 5930842 D 661410 CDS YP_003071333.1 254564238 8195015 complement(5931329..5932375) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative hybrid histidine kinase 5932375 8195015 METDI5931 Methylobacterium extorquens DM4 putative hybrid histidine kinase YP_003071333.1 5931329 R 661410 CDS YP_003071334.1 254564239 8195016 complement(5932372..5932785) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative response regulator receiver (CheY-like protein) 5932785 8195016 METDI5932 Methylobacterium extorquens DM4 putative response regulator receiver (CheY-like protein) YP_003071334.1 5932372 R 661410 CDS YP_003071335.1 254564240 8195017 complement(5932821..5934719) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative histidine kinase 5934719 8195017 METDI5933 Methylobacterium extorquens DM4 putative histidine kinase YP_003071335.1 5932821 R 661410 CDS YP_003071336.1 254564241 8195018 5935073..5935945 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative regulatory protein, Crp (cAMP receptor protein) 5935945 8195018 METDI5934 Methylobacterium extorquens DM4 putative regulatory protein, Crp (cAMP receptor protein) YP_003071336.1 5935073 D 661410 CDS YP_003071337.1 254564242 8195019 complement(5935994..5937925) 1 NC_012988.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative response regulator with unusual domain prganisation: Domains: GAF, PAS, PAC, CheY-like and HTHLuxR 5937925 8195019 METDI5935 Methylobacterium extorquens DM4 putative response regulator with unusual domain prganisation: Domains: GAF, PAS, PAC, CheY-like and HTHLuxR YP_003071337.1 5935994 R 661410 CDS YP_003071338.1 254564243 8195020 complement(5938680..5938904) 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 5938904 8195020 METDI5936 Methylobacterium extorquens DM4 hypothetical protein YP_003071338.1 5938680 R 661410 CDS YP_003071339.1 254564244 8195021 5938957..5939280 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 5939280 8195021 METDI5937 Methylobacterium extorquens DM4 hypothetical protein YP_003071339.1 5938957 D 661410 CDS YP_003071340.1 254564245 8195022 5939432..5939863 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5939863 8195022 METDI5938 Methylobacterium extorquens DM4 hypothetical protein YP_003071340.1 5939432 D 661410 CDS YP_003071341.1 254564246 8195023 complement(5939885..5940163) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 5940163 8195023 METDI5939 Methylobacterium extorquens DM4 hypothetical protein YP_003071341.1 5939885 R 661410 CDS YP_003071342.1 254564247 8195024 5940447..5941199 1 NC_012988.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5941199 8195024 METDI5940 Methylobacterium extorquens DM4 hypothetical protein YP_003071342.1 5940447 D 661410 CDS YP_003071343.1 254564248 8195025 complement(5941773..5941976) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 5941976 8195025 METDI5941 Methylobacterium extorquens DM4 hypothetical protein YP_003071343.1 5941773 R 661410 CDS YP_003071344.1 254564249 8195026 5941953..5942165 1 NC_012988.1 Evidence 6 : Doubtful CDS; hypothetical protein 5942165 8195026 METDI5942 Methylobacterium extorquens DM4 hypothetical protein YP_003071344.1 5941953 D 661410 CDS YP_003071345.1 254564250 8195027 5942385..5942624 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 5942624 8195027 METDI5943 Methylobacterium extorquens DM4 hypothetical protein YP_003071345.1 5942385 D 661410 CDS YP_003071346.1 254564251 8195028 complement(5942774..5942956) 1 NC_012988.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 5942956 8195028 METDI5944 Methylobacterium extorquens DM4 hypothetical protein YP_003071346.1 5942774 R 661410 CDS YP_003071347.1 254564252 8196266 5943401..5943667 1 NC_012988.1 binds directly to the 16S rRNA and is involved in post-translational inhibition of arginine and ornithine decarboxylase; 30S ribosomal protein S20 5943667 rpsT 8196266 rpsT Methylobacterium extorquens DM4 30S ribosomal protein S20 YP_003071347.1 5943401 D 661410 CDS YP_003071348.1 254564254 8196423 15..1034 1 NC_012989.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 10094701; Product type e : enzyme; Phosphate acetyltransferase (Phosphotransacetylase) 1034 pta 8196423 pta Methylobacterium extorquens DM4 Phosphate acetyltransferase (Phosphotransacetylase) YP_003071348.1 15 D 661410 CDS YP_003071349.1 254564255 8196422 1031..2206 1 NC_012989.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 10094701; Product type e : enzyme; acetate kinase 2206 ackA 8196422 ackA Methylobacterium extorquens DM4 acetate kinase YP_003071349.1 1031 D 661410 CDS YP_003071350.1 254564256 8196415 complement(3132..4169) 1 NC_012989.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcriptional regulator protein (AraC family) 4169 8196415 p2METDI0003 Methylobacterium extorquens DM4 putative transcriptional regulator protein (AraC family) YP_003071350.1 3132 R 661410 CDS YP_003071351.1 254564257 8196424 4282..4743 1 NC_012989.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative Regulator of ribonuclease activity A 4743 8196424 p2METDI0004 Methylobacterium extorquens DM4 putative Regulator of ribonuclease activity A YP_003071351.1 4282 D 661410 CDS YP_003071352.1 254564258 8196425 4743..5339 1 NC_012989.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5339 8196425 p2METDI0005 Methylobacterium extorquens DM4 hypothetical protein YP_003071352.1 4743 D 661410 CDS YP_003071353.1 254564259 8196426 complement(5606..6517) 1 NC_012989.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative Homoserine kinase 6517 8196426 p2METDI0006 Methylobacterium extorquens DM4 putative Homoserine kinase YP_003071353.1 5606 R 661410 CDS YP_003071354.1 254564260 8196386 6773..7315 1 NC_012989.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type h : extrachromosomal origin; e14 prophage; inversion of adjacent DNA 7315 pinE 8196386 pinE Methylobacterium extorquens DM4 e14 prophage; inversion of adjacent DNA YP_003071354.1 6773 D 661410 CDS YP_003071355.1 254564261 8196421 7320..7760 1 NC_012989.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 7760 8196421 p2METDI0008 Methylobacterium extorquens DM4 hypothetical protein YP_003071355.1 7320 D 661410 CDS YP_003071356.1 254564262 8196387 7913..8596 1 NC_012989.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 8596 8196387 p2METDI0009 Methylobacterium extorquens DM4 hypothetical protein YP_003071356.1 7913 D 661410 CDS YP_003071357.1 254564263 8196388 8640..8837 1 NC_012989.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 8837 8196388 p2METDI0010 Methylobacterium extorquens DM4 hypothetical protein YP_003071357.1 8640 D 661410 CDS YP_003071358.1 254564264 8196389 8957..9733 1 NC_012989.1 Evidence 2b : Function of strongly homologous gene; hypothetical protein 9733 8196389 p2METDI0011 Methylobacterium extorquens DM4 hypothetical protein YP_003071358.1 8957 D 661410 CDS YP_003071359.1 254564265 8196390 10287..10943 1 NC_012989.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative ATPase, putative partition protein (ParA) 10943 8196390 p2METDI0012 Methylobacterium extorquens DM4 putative ATPase, putative partition protein (ParA) YP_003071359.1 10287 D 661410 CDS YP_003071360.1 254564266 8196391 10999..11214 1 NC_012989.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 11214 8196391 p2METDI0013 Methylobacterium extorquens DM4 hypothetical protein YP_003071360.1 10999 D 661410 CDS YP_003071361.1 254564267 8196392 11383..12399 1 NC_012989.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 12399 8196392 p2METDI0014 Methylobacterium extorquens DM4 hypothetical protein YP_003071361.1 11383 D 661410 CDS YP_003071362.1 254564268 8196393 12567..13877 1 NC_012989.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; transposase of ISMex3, IS256 family 13877 8196393 p2METDI0015 Methylobacterium extorquens DM4 transposase of ISMex3, IS256 family YP_003071362.1 12567 D 661410 CDS YP_003071363.1 254564269 8196394 14697..16064 1 NC_012989.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 16064 8196394 p2METDI0016 Methylobacterium extorquens DM4 hypothetical protein YP_003071363.1 14697 D 661410 CDS YP_003071364.1 254564270 8196396 complement(15726..17114) 1 NC_012989.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 17114 8196396 p2METDI0018 Methylobacterium extorquens DM4 hypothetical protein YP_003071364.1 15726 R 661410 CDS YP_003071365.1 254564271 8196397 complement(17129..18208) 1 NC_012989.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 18208 8196397 p2METDI0019 Methylobacterium extorquens DM4 hypothetical protein YP_003071365.1 17129 R 661410 CDS YP_003071366.1 254564272 8196398 complement(18372..19178) 1 NC_012989.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 19178 8196398 p2METDI0020 Methylobacterium extorquens DM4 hypothetical protein YP_003071366.1 18372 R 661410 CDS YP_003071367.1 254564273 8196399 complement(19196..20026) 1 NC_012989.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 20026 8196399 p2METDI0021 Methylobacterium extorquens DM4 hypothetical protein YP_003071367.1 19196 R 661410 CDS YP_003071368.1 254564274 8196400 complement(20077..20514) 1 NC_012989.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 20514 8196400 p2METDI0022 Methylobacterium extorquens DM4 hypothetical protein YP_003071368.1 20077 R 661410 CDS YP_003071369.1 254564275 8196401 20799..21098 1 NC_012989.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 21098 8196401 p2METDI0023 Methylobacterium extorquens DM4 hypothetical protein YP_003071369.1 20799 D 661410 CDS YP_003071370.1 254564276 8196402 21119..24472 1 NC_012989.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 24472 8196402 p2METDI0024 Methylobacterium extorquens DM4 hypothetical protein YP_003071370.1 21119 D 661410 CDS YP_003071371.1 254564277 8196403 25245..26303 1 NC_012989.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; Endonuclease/exonuclease/phosphatase 26303 8196403 p2METDI0025 Methylobacterium extorquens DM4 Endonuclease/exonuclease/phosphatase YP_003071371.1 25245 D 661410 CDS YP_003071372.1 254564278 8196404 complement(26264..26410) 1 NC_012989.1 Evidence 6 : Doubtful CDS; hypothetical protein 26410 8196404 p2METDI0026 Methylobacterium extorquens DM4 hypothetical protein YP_003071372.1 26264 R 661410 CDS YP_003071373.1 254564279 8196405 complement(26456..27751) 1 NC_012989.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 15004242, 1535622, 7721697, 95355341; Product type t : transporter; arsenical pump (Ars family) 27751 arsB 8196405 arsB Methylobacterium extorquens DM4 arsenical pump (Ars family) YP_003071373.1 26456 R 661410 CDS YP_003071374.1 254564280 8196416 complement(27786..28211) 1 NC_012989.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 16905151, 17432936; Product type e : enzyme; arsenate reductase (glutaredoxin family) 28211 arsC 8196416 arsC Methylobacterium extorquens DM4 arsenate reductase (glutaredoxin family) YP_003071374.1 27786 R 661410 CDS YP_003071375.1 254564281 8196417 complement(28211..28738) 1 NC_012989.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 11573087, 16905151; Product type e : enzyme; arsenate reductase / phosphotyrosine protein phosphatase 28738 arsC 8196417 arsC Methylobacterium extorquens DM4 arsenate reductase / phosphotyrosine protein phosphatase YP_003071375.1 28211 R 661410 CDS YP_003071376.1 254564282 8196418 complement(28731..29093) 1 NC_012989.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 10788346, 12829264, 9537360; Product type r : regulator; transcriptional regulator, ArsR family 29093 arsR 8196418 arsR Methylobacterium extorquens DM4 transcriptional regulator, ArsR family YP_003071376.1 28731 R 661410 CDS YP_003071377.1 254564283 8196419 29141..29887 1 NC_012989.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; NADPH-dependent FMN reductase 29887 8196419 p2METDI0031 Methylobacterium extorquens DM4 NADPH-dependent FMN reductase YP_003071377.1 29141 D 661410 CDS YP_003071378.1 254564284 8196406 complement(30105..30515) 1 NC_012989.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 30515 8196406 p2METDI0032 Methylobacterium extorquens DM4 hypothetical protein YP_003071378.1 30105 R 661410 CDS YP_003071379.1 254564285 8196407 complement(30737..31000) 1 NC_012989.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 31000 8196407 p2METDI0033 Methylobacterium extorquens DM4 hypothetical protein YP_003071379.1 30737 R 661410 CDS YP_003071380.1 254564286 8196409 complement(31958..33079) 1 NC_012989.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; transposase of ISMex18, IS630 family 33079 8196409 p2METDI0035 Methylobacterium extorquens DM4 transposase of ISMex18, IS630 family YP_003071380.1 31958 R 661410 CDS YP_003071381.1 254564287 8196412 33986..34234 1 NC_012989.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 34234 8196412 p2METDI0038 Methylobacterium extorquens DM4 hypothetical protein YP_003071381.1 33986 D 661410 CDS YP_003071382.1 254564288 8196413 complement(34251..34457) 1 NC_012989.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 34457 8196413 p2METDI0039 Methylobacterium extorquens DM4 hypothetical protein YP_003071382.1 34251 R 661410 CDS YP_003071383.1 254564289 8196414 34969..35724 1 NC_012989.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 10398587, 2687243; Product type e : enzyme; Enoyl-[acyl-carrier-protein] reductase (NADH) 35724 fabI 8196414 fabI Methylobacterium extorquens DM4 Enoyl-[acyl-carrier-protein] reductase (NADH) YP_003071383.1 34969 D 661410 CDS YP_003071384.1 254564290 8196420 35988..38207 1 NC_012989.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 38207 8196420 p2METDI0041 Methylobacterium extorquens DM4 hypothetical protein YP_003071384.1 35988 D 661410 CDS