-- dump date 20140619_140957 -- class Genbank::misc_feature -- table misc_feature_note -- id note 266835000001 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 266835000002 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 266835000003 Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653 266835000004 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 266835000005 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 266835000006 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 266835000007 catalytic triad [active] 266835000008 Protein of unknown function; Region: DUF3971; pfam13116 266835000009 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 266835000010 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 266835000011 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 266835000012 active site 266835000013 HIGH motif; other site 266835000014 dimer interface [polypeptide binding]; other site 266835000015 KMSKS motif; other site 266835000016 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 266835000017 RNA binding surface [nucleotide binding]; other site 266835000018 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 266835000019 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 266835000020 Ligand binding site; other site 266835000021 Putative Catalytic site; other site 266835000022 DXD motif; other site 266835000023 Predicted membrane protein [Function unknown]; Region: COG3952 266835000024 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 266835000025 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 266835000026 PAP2_like proteins, Lipid A 1-phosphatase subfamily. Lipid A 1-phosphatase, or LpxE from Francisella novicida selectively dephosphorylates lipid A at the 1-position. Lipid A is the membrane-anchor component of lipopolysaccharides (LPS), the major...; Region: PAP2_lipid_A_1_phosphatase; cd03389 266835000027 active site 266835000028 Transcriptional regulator [Transcription]; Region: PaiB; COG2808 266835000029 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 266835000030 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 266835000031 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 266835000032 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 266835000033 catalytic residue [active] 266835000034 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 266835000035 putative ABC transporter; Region: ycf24; CHL00085 266835000036 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 266835000037 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 266835000038 Walker A/P-loop; other site 266835000039 ATP binding site [chemical binding]; other site 266835000040 Q-loop/lid; other site 266835000041 ABC transporter signature motif; other site 266835000042 Walker B; other site 266835000043 D-loop; other site 266835000044 H-loop/switch region; other site 266835000045 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 266835000046 FeS assembly protein SufD; Region: sufD; TIGR01981 266835000047 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 266835000048 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 266835000049 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 266835000050 catalytic residue [active] 266835000051 FeS assembly SUF system protein; Region: SUF_assoc; TIGR02945 266835000052 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 266835000053 Uncharacterized conserved protein [Function unknown]; Region: COG3791 266835000054 TfoX N-terminal domain; Region: TfoX_N; pfam04993 266835000055 Uncharacterized enzyme involved in pigment biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IndA; COG2313 266835000056 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 266835000057 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 266835000058 substrate binding site [chemical binding]; other site 266835000059 ATP binding site [chemical binding]; other site 266835000060 recombinase A; Provisional; Region: recA; PRK09354 266835000061 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 266835000062 hexamer interface [polypeptide binding]; other site 266835000063 Walker A motif; other site 266835000064 ATP binding site [chemical binding]; other site 266835000065 Walker B motif; other site 266835000066 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 266835000067 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 266835000068 motif 1; other site 266835000069 active site 266835000070 motif 2; other site 266835000071 motif 3; other site 266835000072 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 266835000073 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 266835000074 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835000075 GST_N family, Class Phi subfamily; composed of plant-specific class Phi GSTs and related fungal and bacterial proteins. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide...; Region: GST_N_Phi; cd03053 266835000076 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 266835000077 C-terminal domain interface [polypeptide binding]; other site 266835000078 GSH binding site (G-site) [chemical binding]; other site 266835000079 dimer interface [polypeptide binding]; other site 266835000080 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 266835000081 dimer interface [polypeptide binding]; other site 266835000082 N-terminal domain interface [polypeptide binding]; other site 266835000083 substrate binding pocket (H-site) [chemical binding]; other site 266835000084 isocitrate dehydrogenase; Validated; Region: PRK08299 266835000085 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 266835000086 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 266835000087 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 266835000088 Glutamate racemase [Cell envelope biogenesis, outer membrane]; Region: MurI; COG0796 266835000089 RNB domain; Region: RNB; pfam00773 266835000090 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 266835000091 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 266835000092 RNA binding site [nucleotide binding]; other site 266835000093 Protein of unknwon function (DUF3008); Region: DUF3008; pfam11450 266835000094 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 266835000095 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 266835000096 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 266835000097 RNA binding surface [nucleotide binding]; other site 266835000098 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 266835000099 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 266835000100 Ligand Binding Site [chemical binding]; other site 266835000101 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 266835000102 PAP-phosphatase_like domains. PAP-phosphatase is a member of the inositol monophosphatase family, and catalyses the hydrolysis of 3'-phosphoadenosine-5'-phosphate (PAP) to AMP. In Saccharomyces cerevisiae, HAL2 (MET22) is involved in methionine...; Region: PAP_phosphatase; cd01517 266835000103 active site 266835000104 putative lithium-binding site [ion binding]; other site 266835000105 substrate binding site [chemical binding]; other site 266835000106 Gram-negative bacterial tonB protein; Region: TonB; cl10048 266835000107 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266835000108 putative substrate translocation pore; other site 266835000109 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 266835000110 putative GSH binding site [chemical binding]; other site 266835000111 catalytic residues [active] 266835000112 Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271 266835000113 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 266835000114 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 266835000115 dimerization interface [polypeptide binding]; other site 266835000116 ATP binding site [chemical binding]; other site 266835000117 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 266835000118 dimerization interface [polypeptide binding]; other site 266835000119 ATP binding site [chemical binding]; other site 266835000120 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 266835000121 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266835000122 DNA-binding site [nucleotide binding]; DNA binding site 266835000123 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 266835000124 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266835000125 homodimer interface [polypeptide binding]; other site 266835000126 catalytic residue [active] 266835000127 Uncharacterized conserved small protein [Function unknown]; Region: COG5457 266835000128 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 266835000129 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 266835000130 C-terminal domain interface [polypeptide binding]; other site 266835000131 GSH binding site (G-site) [chemical binding]; other site 266835000132 dimer interface [polypeptide binding]; other site 266835000133 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 266835000134 N-terminal domain interface [polypeptide binding]; other site 266835000135 dimer interface [polypeptide binding]; other site 266835000136 substrate binding pocket (H-site) [chemical binding]; other site 266835000137 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 266835000138 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 266835000139 putative active site [active] 266835000140 catalytic triad [active] 266835000141 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 266835000142 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 266835000143 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 266835000144 ATP binding site [chemical binding]; other site 266835000145 active site 266835000146 substrate binding site [chemical binding]; other site 266835000147 Uncharacterized conserved protein [Function unknown]; Region: COG5467 266835000148 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836 266835000149 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 266835000150 Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545 266835000151 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 266835000152 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 266835000153 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 266835000154 putative metal binding site [ion binding]; other site 266835000155 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 266835000156 active site 266835000157 adenylosuccinate lyase; Provisional; Region: PRK07492 266835000158 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 266835000159 tetramer interface [polypeptide binding]; other site 266835000160 active site 266835000161 Predicted secreted protein (DUF2259); Region: DUF2259; pfam10016 266835000162 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3798 266835000163 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 266835000164 putative active site pocket [active] 266835000165 cleavage site 266835000166 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 266835000167 cleavage site 266835000168 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 266835000169 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 266835000170 Flavin Reductases; Region: FlaRed; cl00801 266835000171 MoxR-like ATPases [General function prediction only]; Region: COG0714 266835000172 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266835000173 Walker A motif; other site 266835000174 ATP binding site [chemical binding]; other site 266835000175 Walker B motif; other site 266835000176 arginine finger; other site 266835000177 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 266835000178 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 266835000179 metal ion-dependent adhesion site (MIDAS); other site 266835000180 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 266835000181 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 266835000182 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 266835000183 XdhC Rossmann domain; Region: XdhC_C; pfam13478 266835000184 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 266835000185 MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is...; Region: MoeA_like; cd03522 266835000186 putative MPT binding site; other site 266835000187 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 266835000188 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 266835000189 Ligand binding site; other site 266835000190 metal-binding site 266835000191 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 266835000192 Protein of unknown function (DUF1176); Region: DUF1176; pfam06674 266835000193 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3812 266835000194 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 266835000195 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 266835000196 active site 266835000197 catalytic tetrad [active] 266835000198 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 266835000199 cysteine desulfurase family protein, VC1184 subfamily; Region: am_tr_V_VC1184; TIGR01976 266835000200 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 266835000201 catalytic residue [active] 266835000202 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 266835000203 Histone deacetylase class IIa; Region: HDAC_classII_APAH; cd10001 266835000204 active site 266835000205 Zn binding site [ion binding]; other site 266835000206 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 266835000207 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 266835000208 Coenzyme A binding pocket [chemical binding]; other site 266835000209 Uncharacterized conserved protein [Function unknown]; Region: COG1683 266835000210 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 266835000211 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 266835000212 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 266835000213 inhibitor-cofactor binding pocket; inhibition site 266835000214 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266835000215 catalytic residue [active] 266835000216 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 266835000217 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 266835000218 ParB-like nuclease domain; Region: ParB; smart00470 266835000219 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_3; cd08896 266835000220 putative hydrophobic ligand binding site [chemical binding]; other site 266835000221 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 266835000222 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 266835000223 Uncharacterized conserved protein [Function unknown]; Region: COG3791 266835000224 Bacitracin resistance protein BacA; Region: BacA; pfam02673 266835000225 Bacterial transglutaminase-like cysteine proteinase BTLCP; Region: BTLCP; pfam06035 266835000226 Predicted periplasmic protein [Function unknown]; Region: COG3698 266835000227 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 266835000228 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 266835000229 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 266835000230 Protein of unknown function (DUF1402); Region: DUF1402; pfam07182 266835000231 Lyzozyme M1 (1,4-beta-N-acetylmuramidase) [Cell envelope biogenesis, outer membrane]; Region: Acm; COG3757 266835000232 Uncharacterized bacterial muramidase containing a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis...; Region: GH25_muramidase_1; cd06413 266835000233 active site 266835000234 MoeA C-terminal region (domain IV); Region: MoeA_C; pfam03454 266835000235 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 266835000236 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266835000237 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 266835000238 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266835000239 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 266835000240 dimerization interface [polypeptide binding]; other site 266835000241 substrate binding pocket [chemical binding]; other site 266835000242 Methyltransferase domain; Region: Methyltransf_23; pfam13489 266835000243 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266835000244 S-adenosylmethionine binding site [chemical binding]; other site 266835000245 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 266835000246 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 266835000247 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 266835000248 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07562 266835000249 Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471 266835000250 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 266835000251 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 266835000252 active site 266835000253 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 266835000254 TSCPD domain; Region: TSCPD; pfam12637 266835000255 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_9; cd04666 266835000256 nudix motif; other site 266835000257 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 266835000258 active site 266835000259 Universal stress protein family; Region: Usp; pfam00582 266835000260 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 266835000261 Ligand Binding Site [chemical binding]; other site 266835000262 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058 266835000263 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 266835000264 putative MPT binding site; other site 266835000265 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 266835000266 Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; pfam09954 266835000267 Protein of unknown function (DUF982); Region: DUF982; pfam06169 266835000268 Bacterial SH3 domain; Region: SH3_3; pfam08239 266835000269 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 266835000270 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 266835000271 active site 266835000272 FMN binding site [chemical binding]; other site 266835000273 substrate binding site [chemical binding]; other site 266835000274 homotetramer interface [polypeptide binding]; other site 266835000275 catalytic residue [active] 266835000276 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 266835000277 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 266835000278 dimer interface [polypeptide binding]; other site 266835000279 ADP-ribose binding site [chemical binding]; other site 266835000280 active site 266835000281 nudix motif; other site 266835000282 metal binding site [ion binding]; metal-binding site 266835000283 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 266835000284 active sites [active] 266835000285 tetramer interface [polypeptide binding]; other site 266835000286 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 266835000287 Preprotein translocase subunit SecD [Intracellular trafficking and secretion]; Region: SecD; COG0342 266835000288 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 266835000289 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 266835000290 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 266835000291 active site 266835000292 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 266835000293 Alpha/beta hydrolase of unknown function (DUF900); Region: DUF900; pfam05990 266835000294 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4782 266835000295 threonine dehydratase; Validated; Region: PRK08639 266835000296 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 266835000297 tetramer interface [polypeptide binding]; other site 266835000298 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266835000299 catalytic residue [active] 266835000300 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 266835000301 putative Ile/Val binding site [chemical binding]; other site 266835000302 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3797 266835000303 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3553 266835000304 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266835000305 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 266835000306 dimer interface [polypeptide binding]; other site 266835000307 active site 266835000308 metal binding site [ion binding]; metal-binding site 266835000309 glutathione binding site [chemical binding]; other site 266835000310 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 266835000311 DNA-binding site [nucleotide binding]; DNA binding site 266835000312 RNA-binding motif; other site 266835000313 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 266835000314 DNA-binding site [nucleotide binding]; DNA binding site 266835000315 RNA-binding motif; other site 266835000316 Uncharacterized conserved protein [Function unknown]; Region: COG1430 266835000317 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 266835000318 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 266835000319 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4339 266835000320 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 266835000321 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266835000322 serine acetyltransferase; Provisional; Region: cysE; PRK11132 266835000323 Serine acetyltransferase, N-terminal; Region: SATase_N; smart00971 266835000324 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 266835000325 trimer interface [polypeptide binding]; other site 266835000326 active site 266835000327 substrate binding site [chemical binding]; other site 266835000328 CoA binding site [chemical binding]; other site 266835000329 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 266835000330 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 266835000331 trimer interface [polypeptide binding]; other site 266835000332 putative metal binding site [ion binding]; other site 266835000333 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 266835000334 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 266835000335 Bacterial transglutaminase-like cysteine proteinase BTLCP; Region: BTLCP; pfam06035 266835000336 PilZ domain; Region: PilZ; pfam07238 266835000337 PilZ domain; Region: PilZ; pfam07238 266835000338 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5388 266835000339 PAS domain; Region: PAS_5; pfam07310 266835000340 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 266835000341 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 266835000342 FOG: CBS domain [General function prediction only]; Region: COG0517 266835000343 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3811 266835000344 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 266835000345 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 266835000346 GatB domain; Region: GatB_Yqey; smart00845 266835000347 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 266835000348 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 266835000349 Uncharacterized conserved protein [Function unknown]; Region: COG2013 266835000350 Pantoate-beta-alanine ligase; Region: PanC; cd00560 266835000351 pantoate--beta-alanine ligase; Region: panC; TIGR00018 266835000352 active site 266835000353 ATP-binding site [chemical binding]; other site 266835000354 pantoate-binding site; other site 266835000355 HXXH motif; other site 266835000356 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 266835000357 oligomerization interface [polypeptide binding]; other site 266835000358 active site 266835000359 metal binding site [ion binding]; metal-binding site 266835000360 NADH dehydrogenase; Validated; Region: PRK08183 266835000361 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4765 266835000362 Leu/Phe-tRNA-protein transferase [Posttranslational modification, protein turnover, chaperones]; Region: Aat; COG2360 266835000363 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 266835000364 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 266835000365 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 266835000366 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 266835000367 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 266835000368 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 266835000369 carboxyltransferase (CT) interaction site; other site 266835000370 biotinylation site [posttranslational modification]; other site 266835000371 Dehydroquinase class II; Region: DHquinase_II; pfam01220 266835000372 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 266835000373 trimer interface [polypeptide binding]; other site 266835000374 active site 266835000375 dimer interface [polypeptide binding]; other site 266835000376 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 266835000377 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 266835000378 catalytic residues [active] 266835000379 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 266835000380 Peptidase family M48; Region: Peptidase_M48; cl12018 266835000381 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266835000382 TPR motif; other site 266835000383 binding surface 266835000384 aspartate aminotransferase; Provisional; Region: PRK05764 266835000385 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 266835000386 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266835000387 homodimer interface [polypeptide binding]; other site 266835000388 catalytic residue [active] 266835000389 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 266835000390 glutaminase; Provisional; Region: PRK00971 266835000391 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 266835000392 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 266835000393 Ribonuclease E/G family; Region: RNase_E_G; pfam10150 266835000394 AMIN domain; Region: AMIN; pfam11741 266835000395 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 266835000396 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 266835000397 active site 266835000398 metal binding site [ion binding]; metal-binding site 266835000399 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 266835000400 Transglycosylase; Region: Transgly; pfam00912 266835000401 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 266835000402 peptide chain release factor 2; Provisional; Region: PRK07342 266835000403 This domain is found in peptide chain release factors; Region: PCRF; smart00937 266835000404 RF-1 domain; Region: RF-1; pfam00472 266835000405 Uncharacterized conserved protein [Function unknown]; Region: COG3791 266835000406 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 266835000407 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 266835000408 ligand binding site [chemical binding]; other site 266835000409 helicase 45; Provisional; Region: PTZ00424 266835000410 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 266835000411 ATP binding site [chemical binding]; other site 266835000412 Mg++ binding site [ion binding]; other site 266835000413 motif III; other site 266835000414 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 266835000415 nucleotide binding region [chemical binding]; other site 266835000416 ATP-binding site [chemical binding]; other site 266835000417 inorganic polyphosphate/ATP-NAD kinase; Reviewed; Region: ppnK; PRK04761 266835000418 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 266835000419 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 266835000420 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 266835000421 Amidase; Region: Amidase; cl11426 266835000422 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266835000423 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266835000424 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 266835000425 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 266835000426 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266835000427 Walker A/P-loop; other site 266835000428 ATP binding site [chemical binding]; other site 266835000429 Q-loop/lid; other site 266835000430 ABC transporter signature motif; other site 266835000431 Walker B; other site 266835000432 D-loop; other site 266835000433 H-loop/switch region; other site 266835000434 TOBE domain; Region: TOBE_2; pfam08402 266835000435 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 266835000436 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835000437 dimer interface [polypeptide binding]; other site 266835000438 conserved gate region; other site 266835000439 putative PBP binding loops; other site 266835000440 ABC-ATPase subunit interface; other site 266835000441 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 266835000442 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835000443 dimer interface [polypeptide binding]; other site 266835000444 conserved gate region; other site 266835000445 putative PBP binding loops; other site 266835000446 ABC-ATPase subunit interface; other site 266835000447 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 266835000448 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 266835000449 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266835000450 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266835000451 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266835000452 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266835000453 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266835000454 dimerization interface [polypeptide binding]; other site 266835000455 NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251 266835000456 NmrA-like family; Region: NmrA; pfam05368 266835000457 NADP binding site [chemical binding]; other site 266835000458 active site 266835000459 regulatory binding site [polypeptide binding]; other site 266835000460 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 266835000461 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 266835000462 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 266835000463 NADH(P)-binding; Region: NAD_binding_10; pfam13460 266835000464 NAD binding site [chemical binding]; other site 266835000465 substrate binding site [chemical binding]; other site 266835000466 putative active site [active] 266835000467 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 266835000468 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 266835000469 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266835000470 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266835000471 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_8; cd08477 266835000472 putative effector binding pocket; other site 266835000473 putative dimerization interface [polypeptide binding]; other site 266835000474 BA14K-like protein; Region: BA14K; pfam07886 266835000475 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 266835000476 Transcriptional regulator [Transcription]; Region: IclR; COG1414 266835000477 Bacterial transcriptional regulator; Region: IclR; pfam01614 266835000478 glyoxylate carboligase; Provisional; Region: PRK11269 266835000479 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 266835000480 PYR/PP interface [polypeptide binding]; other site 266835000481 dimer interface [polypeptide binding]; other site 266835000482 TPP binding site [chemical binding]; other site 266835000483 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 266835000484 Thiamine pyrophosphate (TPP) family, Gcl subfamily, TPP-binding module; composed of proteins similar to Escherichia coli glyoxylate carboligase (Gcl). E. coli glyoxylate carboligase, plays a key role in glyoxylate metabolism where it catalyzes the...; Region: TPP_Gcl; cd02006 266835000485 TPP-binding site [chemical binding]; other site 266835000486 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 266835000487 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 266835000488 tartronate semialdehyde reductase; Provisional; Region: PRK15059 266835000489 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 266835000490 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 266835000491 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 266835000492 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3753 266835000493 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 266835000494 elongation factor Tu; Reviewed; Region: PRK00049 266835000495 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 266835000496 G1 box; other site 266835000497 GEF interaction site [polypeptide binding]; other site 266835000498 GTP/Mg2+ binding site [chemical binding]; other site 266835000499 Switch I region; other site 266835000500 G2 box; other site 266835000501 G3 box; other site 266835000502 Switch II region; other site 266835000503 G4 box; other site 266835000504 G5 box; other site 266835000505 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 266835000506 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 266835000507 Antibiotic Binding Site [chemical binding]; other site 266835000508 Predicted periplasmic protein [Function unknown]; Region: COG3904 266835000509 Predicted periplasmic protein [Function unknown]; Region: COG3904 266835000510 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 266835000511 apolar tunnel; other site 266835000512 heme binding site [chemical binding]; other site 266835000513 dimerization interface [polypeptide binding]; other site 266835000514 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3554 266835000515 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 266835000516 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 266835000517 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 266835000518 putative homodimer interface [polypeptide binding]; other site 266835000519 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 266835000520 heterodimer interface [polypeptide binding]; other site 266835000521 homodimer interface [polypeptide binding]; other site 266835000522 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 266835000523 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 266835000524 23S rRNA interface [nucleotide binding]; other site 266835000525 L7/L12 interface [polypeptide binding]; other site 266835000526 putative thiostrepton binding site; other site 266835000527 L25 interface [polypeptide binding]; other site 266835000528 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 266835000529 mRNA/rRNA interface [nucleotide binding]; other site 266835000530 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 266835000531 23S rRNA interface [nucleotide binding]; other site 266835000532 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 266835000533 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 266835000534 L11 interface [polypeptide binding]; other site 266835000535 putative EF-Tu interaction site [polypeptide binding]; other site 266835000536 putative EF-G interaction site [polypeptide binding]; other site 266835000537 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 266835000538 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 266835000539 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 266835000540 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 266835000541 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 266835000542 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 266835000543 RPB1 interaction site [polypeptide binding]; other site 266835000544 RPB11 interaction site [polypeptide binding]; other site 266835000545 RPB10 interaction site [polypeptide binding]; other site 266835000546 RPB3 interaction site [polypeptide binding]; other site 266835000547 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 266835000548 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 266835000549 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 266835000550 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 266835000551 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 266835000552 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 266835000553 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 266835000554 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 266835000555 Rpb1 - Rpb5 interaction site [polypeptide binding]; other site 266835000556 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 266835000557 DNA binding site [nucleotide binding] 266835000558 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 266835000559 Methyltransferase domain; Region: Methyltransf_31; pfam13847 266835000560 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266835000561 S-adenosylmethionine binding site [chemical binding]; other site 266835000562 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 266835000563 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 266835000564 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 266835000565 S17 interaction site [polypeptide binding]; other site 266835000566 S8 interaction site; other site 266835000567 16S rRNA interaction site [nucleotide binding]; other site 266835000568 streptomycin interaction site [chemical binding]; other site 266835000569 23S rRNA interaction site [nucleotide binding]; other site 266835000570 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 266835000571 30S ribosomal protein S7; Validated; Region: PRK05302 266835000572 elongation factor G; Reviewed; Region: PRK00007 266835000573 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 266835000574 G1 box; other site 266835000575 putative GEF interaction site [polypeptide binding]; other site 266835000576 GTP/Mg2+ binding site [chemical binding]; other site 266835000577 Switch I region; other site 266835000578 G2 box; other site 266835000579 G3 box; other site 266835000580 Switch II region; other site 266835000581 G4 box; other site 266835000582 G5 box; other site 266835000583 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 266835000584 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 266835000585 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 266835000586 elongation factor Tu; Reviewed; Region: PRK00049 266835000587 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 266835000588 G1 box; other site 266835000589 GEF interaction site [polypeptide binding]; other site 266835000590 GTP/Mg2+ binding site [chemical binding]; other site 266835000591 Switch I region; other site 266835000592 G2 box; other site 266835000593 G3 box; other site 266835000594 Switch II region; other site 266835000595 G4 box; other site 266835000596 G5 box; other site 266835000597 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 266835000598 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 266835000599 Antibiotic Binding Site [chemical binding]; other site 266835000600 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 266835000601 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 266835000602 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 266835000603 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 266835000604 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 266835000605 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 266835000606 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 266835000607 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 266835000608 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 266835000609 putative translocon binding site; other site 266835000610 protein-rRNA interface [nucleotide binding]; other site 266835000611 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 266835000612 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 266835000613 G-X-X-G motif; other site 266835000614 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 266835000615 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 266835000616 23S rRNA interface [nucleotide binding]; other site 266835000617 5S rRNA interface [nucleotide binding]; other site 266835000618 putative antibiotic binding site [chemical binding]; other site 266835000619 L25 interface [polypeptide binding]; other site 266835000620 L27 interface [polypeptide binding]; other site 266835000621 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 266835000622 putative translocon interaction site; other site 266835000623 23S rRNA interface [nucleotide binding]; other site 266835000624 signal recognition particle (SRP54) interaction site; other site 266835000625 L23 interface [polypeptide binding]; other site 266835000626 trigger factor interaction site; other site 266835000627 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 266835000628 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 266835000629 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 266835000630 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 266835000631 RNA binding site [nucleotide binding]; other site 266835000632 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 266835000633 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 266835000634 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 266835000635 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 266835000636 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 266835000637 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 266835000638 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 266835000639 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 266835000640 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 266835000641 5S rRNA interface [nucleotide binding]; other site 266835000642 23S rRNA interface [nucleotide binding]; other site 266835000643 L5 interface [polypeptide binding]; other site 266835000644 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 266835000645 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 266835000646 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 266835000647 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 266835000648 23S rRNA binding site [nucleotide binding]; other site 266835000649 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 266835000650 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 266835000651 SecY translocase; Region: SecY; pfam00344 266835000652 adenylate kinase; Reviewed; Region: adk; PRK00279 266835000653 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 266835000654 AMP-binding site [chemical binding]; other site 266835000655 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 266835000656 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 266835000657 30S ribosomal protein S13; Region: bact_S13; TIGR03631 266835000658 30S ribosomal protein S11; Validated; Region: PRK05309 266835000659 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 266835000660 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 266835000661 alphaNTD homodimer interface [polypeptide binding]; other site 266835000662 alphaNTD - beta interaction site [polypeptide binding]; other site 266835000663 alphaNTD - beta' interaction site [polypeptide binding]; other site 266835000664 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 266835000665 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 266835000666 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 266835000667 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 266835000668 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 266835000669 protein binding site [polypeptide binding]; other site 266835000670 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 266835000671 protein binding site [polypeptide binding]; other site 266835000672 recombination factor protein RarA; Reviewed; Region: PRK13342 266835000673 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266835000674 Walker A motif; other site 266835000675 ATP binding site [chemical binding]; other site 266835000676 Walker B motif; other site 266835000677 arginine finger; other site 266835000678 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 266835000679 Domain of Unknown Function (DUF930); Region: DUF930; pfam06059 266835000680 Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555 266835000681 camphor resistance protein CrcB; Provisional; Region: PRK14195 266835000682 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 266835000683 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 266835000684 RNA binding surface [nucleotide binding]; other site 266835000685 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 266835000686 active site 266835000687 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 266835000688 EamA-like transporter family; Region: EamA; pfam00892 266835000689 EamA-like transporter family; Region: EamA; pfam00892 266835000690 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266835000691 putative substrate translocation pore; other site 266835000692 glutamine synthetase; Region: PLN02284 266835000693 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 266835000694 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 266835000695 glutamine synthetase; Provisional; Region: glnA; PRK09469 266835000696 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 266835000697 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 266835000698 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 266835000699 Nitrogen regulatory protein P-II; Region: P-II; smart00938 266835000700 Uncharacterized conserved protein [Function unknown]; Region: COG0062 266835000701 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 266835000702 putative substrate binding site [chemical binding]; other site 266835000703 putative ATP binding site [chemical binding]; other site 266835000704 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 266835000705 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 266835000706 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 266835000707 helicase 45; Provisional; Region: PTZ00424 266835000708 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 266835000709 ATP binding site [chemical binding]; other site 266835000710 Mg++ binding site [ion binding]; other site 266835000711 motif III; other site 266835000712 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 266835000713 nucleotide binding region [chemical binding]; other site 266835000714 ATP-binding site [chemical binding]; other site 266835000715 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 266835000716 classical (c) SDR, subgroup 6; Region: SDR_c6; cd05350 266835000717 short chain dehydrogenase; Provisional; Region: PRK07024 266835000718 putative NAD(P) binding site [chemical binding]; other site 266835000719 active site 266835000720 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 266835000721 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 266835000722 dimer interface [polypeptide binding]; other site 266835000723 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266835000724 catalytic residue [active] 266835000725 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 266835000726 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 266835000727 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 266835000728 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 266835000729 active site residue [active] 266835000730 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 266835000731 active site residue [active] 266835000732 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 266835000733 Coenzyme A binding pocket [chemical binding]; other site 266835000734 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 266835000735 Protein of unknown function (DUF1203); Region: DUF1203; pfam06718 266835000736 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 266835000737 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 266835000738 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 266835000739 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 266835000740 hexamer interface [polypeptide binding]; other site 266835000741 ligand binding site [chemical binding]; other site 266835000742 putative active site [active] 266835000743 NAD(P) binding site [chemical binding]; other site 266835000744 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 266835000745 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266835000746 putative DNA binding site [nucleotide binding]; other site 266835000747 putative Zn2+ binding site [ion binding]; other site 266835000748 AsnC family; Region: AsnC_trans_reg; pfam01037 266835000749 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212 266835000750 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 266835000751 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 266835000752 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420 266835000753 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 266835000754 active site 266835000755 metal binding site [ion binding]; metal-binding site 266835000756 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 266835000757 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 266835000758 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266835000759 S-adenosylmethionine binding site [chemical binding]; other site 266835000760 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 266835000761 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 266835000762 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 266835000763 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 266835000764 PRC-barrel domain; Region: PRC; pfam05239 266835000765 enolase; Provisional; Region: eno; PRK00077 266835000766 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 266835000767 dimer interface [polypeptide binding]; other site 266835000768 metal binding site [ion binding]; metal-binding site 266835000769 substrate binding pocket [chemical binding]; other site 266835000770 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 266835000771 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 266835000772 putative trimer interface [polypeptide binding]; other site 266835000773 putative CoA binding site [chemical binding]; other site 266835000774 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 266835000775 MarR family; Region: MarR; pfam01047 266835000776 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 266835000777 Septum formation initiator; Region: DivIC; pfam04977 266835000778 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 266835000779 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 266835000780 tetramer interface [polypeptide binding]; other site 266835000781 TPP-binding site [chemical binding]; other site 266835000782 heterodimer interface [polypeptide binding]; other site 266835000783 phosphorylation loop region [posttranslational modification] 266835000784 pyruvate dehydrogenase subunit beta; Provisional; Region: PRK11892 266835000785 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 266835000786 E3 interaction surface; other site 266835000787 lipoyl attachment site [posttranslational modification]; other site 266835000788 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 266835000789 alpha subunit interface [polypeptide binding]; other site 266835000790 TPP binding site [chemical binding]; other site 266835000791 heterodimer interface [polypeptide binding]; other site 266835000792 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 266835000793 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 266835000794 pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form; Region: PDHac_trf_mito; TIGR01349 266835000795 E3 interaction surface; other site 266835000796 lipoyl attachment site [posttranslational modification]; other site 266835000797 e3 binding domain; Region: E3_binding; pfam02817 266835000798 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 266835000799 SGNH_hydrolase subfamily, similar to arylesterase (7-aminocephalosporanic acid-deacetylating enzyme) of A. tumefaciens. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of...; Region: SGNH_arylesterase_like; cd01839 266835000800 active site 266835000801 catalytic triad [active] 266835000802 oxyanion hole [active] 266835000803 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 266835000804 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 266835000805 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 266835000806 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 266835000807 Predicted membrane protein [Function unknown]; Region: COG2261 266835000808 lipoyl synthase; Provisional; Region: PRK05481 266835000809 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 266835000810 FeS/SAM binding site; other site 266835000811 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 266835000812 putative coenzyme Q binding site [chemical binding]; other site 266835000813 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 266835000814 bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase protein; Provisional; Region: ispDF; PRK09382 266835000815 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 266835000816 substrate binding site; other site 266835000817 dimer interface; other site 266835000818 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 266835000819 homotrimer interaction site [polypeptide binding]; other site 266835000820 zinc binding site [ion binding]; other site 266835000821 CDP-binding sites; other site 266835000822 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 266835000823 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 266835000824 FMN binding site [chemical binding]; other site 266835000825 active site 266835000826 catalytic residues [active] 266835000827 substrate binding site [chemical binding]; other site 266835000828 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 266835000829 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266835000830 dimer interface [polypeptide binding]; other site 266835000831 phosphorylation site [posttranslational modification] 266835000832 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266835000833 ATP binding site [chemical binding]; other site 266835000834 Mg2+ binding site [ion binding]; other site 266835000835 G-X-G motif; other site 266835000836 nitrogen regulation protein NR(I); Region: ntrC; TIGR01818 266835000837 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266835000838 active site 266835000839 phosphorylation site [posttranslational modification] 266835000840 intermolecular recognition site; other site 266835000841 dimerization interface [polypeptide binding]; other site 266835000842 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266835000843 Walker A motif; other site 266835000844 ATP binding site [chemical binding]; other site 266835000845 Walker B motif; other site 266835000846 arginine finger; other site 266835000847 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 266835000848 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 266835000849 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 266835000850 dimerization interface [polypeptide binding]; other site 266835000851 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 266835000852 putative active site [active] 266835000853 heme pocket [chemical binding]; other site 266835000854 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266835000855 dimer interface [polypeptide binding]; other site 266835000856 phosphorylation site [posttranslational modification] 266835000857 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266835000858 ATP binding site [chemical binding]; other site 266835000859 Mg2+ binding site [ion binding]; other site 266835000860 G-X-G motif; other site 266835000861 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 266835000862 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266835000863 active site 266835000864 phosphorylation site [posttranslational modification] 266835000865 intermolecular recognition site; other site 266835000866 dimerization interface [polypeptide binding]; other site 266835000867 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266835000868 Walker A motif; other site 266835000869 ATP binding site [chemical binding]; other site 266835000870 Walker B motif; other site 266835000871 arginine finger; other site 266835000872 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 266835000873 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 266835000874 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 266835000875 homodimer interface [polypeptide binding]; other site 266835000876 substrate-cofactor binding pocket; other site 266835000877 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266835000878 catalytic residue [active] 266835000879 bacterial Hfq-like; Region: Hfq; cd01716 266835000880 hexamer interface [polypeptide binding]; other site 266835000881 Sm1 motif; other site 266835000882 RNA binding site [nucleotide binding]; other site 266835000883 Sm2 motif; other site 266835000884 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 266835000885 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 266835000886 HflX GTPase family; Region: HflX; cd01878 266835000887 G1 box; other site 266835000888 GTP/Mg2+ binding site [chemical binding]; other site 266835000889 Switch I region; other site 266835000890 G2 box; other site 266835000891 G3 box; other site 266835000892 Switch II region; other site 266835000893 G4 box; other site 266835000894 G5 box; other site 266835000895 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 266835000896 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 266835000897 homodimer interface [polypeptide binding]; other site 266835000898 metal binding site [ion binding]; metal-binding site 266835000899 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 266835000900 homodimer interface [polypeptide binding]; other site 266835000901 active site 266835000902 putative chemical substrate binding site [chemical binding]; other site 266835000903 metal binding site [ion binding]; metal-binding site 266835000904 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 266835000905 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 266835000906 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266835000907 homodimer interface [polypeptide binding]; other site 266835000908 catalytic residue [active] 266835000909 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 266835000910 catalytic core [active] 266835000911 RNA polymerase sigma factor; Provisional; Region: PRK12511 266835000912 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 266835000913 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 266835000914 DNA binding residues [nucleotide binding] 266835000915 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 266835000916 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 266835000917 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 266835000918 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 266835000919 active site 266835000920 catalytic residues [active] 266835000921 agmatinase; Region: agmatinase; TIGR01230 266835000922 Agmatinase and related proteins; Region: Agmatinase_like_1; cd11589 266835000923 oligomer interface [polypeptide binding]; other site 266835000924 active site 266835000925 Mn binding site [ion binding]; other site 266835000926 Predicted flavoprotein [General function prediction only]; Region: COG0431 266835000927 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 266835000928 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 266835000929 Coenzyme A binding pocket [chemical binding]; other site 266835000930 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 266835000931 putative hydrolase; Provisional; Region: PRK02113 266835000932 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 266835000933 active site 266835000934 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 266835000935 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 266835000936 active site 266835000937 HIGH motif; other site 266835000938 KMSKS motif; other site 266835000939 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 266835000940 tRNA binding surface [nucleotide binding]; other site 266835000941 anticodon binding site; other site 266835000942 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 266835000943 DNA polymerase III subunit delta'; Validated; Region: PRK09112 266835000944 DNA polymerase III subunit delta'; Validated; Region: PRK08485 266835000945 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 266835000946 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 266835000947 TMP-binding site; other site 266835000948 ATP-binding site [chemical binding]; other site 266835000949 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 266835000950 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 266835000951 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 266835000952 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 266835000953 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 266835000954 Protein of unknown function (DUF768); Region: DUF768; pfam05589 266835000955 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 266835000956 Protein of unknown function (DUF768); Region: DUF768; pfam05589 266835000957 Murein lipoprotein [Cell envelope biogenesis, outer membrane]; Region: COG4238 266835000958 Phage-related lysozyme (muraminidase) [General function prediction only]; Region: COG3772 266835000959 catalytic residue [active] 266835000960 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 266835000961 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 266835000962 RecB family nuclease, putative, TM0106 family; Region: TIGR03491 266835000963 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 266835000964 Terminase-like family; Region: Terminase_6; pfam03237 266835000965 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 266835000966 Switch II region; other site 266835000967 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 266835000968 Int/Topo IB signature motif; other site 266835000969 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 266835000970 Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525 266835000971 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 266835000972 Catalytic site; other site 266835000973 Uncharacterized conserved protein [Function unknown]; Region: COG4983 266835000974 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 266835000975 integrase; Provisional; Region: PRK09692 266835000976 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 266835000977 active site 266835000978 Int/Topo IB signature motif; other site 266835000979 Domain of unknown function (DUF4142); Region: DUF4142; cl17876 266835000980 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266835000981 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 266835000982 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266835000983 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 266835000984 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 266835000985 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 266835000986 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 266835000987 Uncharacterized conserved protein [Function unknown]; Region: COG5482 266835000988 Domain of Unknown Function (DUF930); Region: DUF930; pfam06059 266835000989 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 266835000990 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 266835000991 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 266835000992 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 266835000993 FeS/SAM binding site; other site 266835000994 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 266835000995 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 266835000996 putative ligand binding site [chemical binding]; other site 266835000997 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 266835000998 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 266835000999 TM-ABC transporter signature motif; other site 266835001000 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 266835001001 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 266835001002 TM-ABC transporter signature motif; other site 266835001003 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 266835001004 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 266835001005 Walker A/P-loop; other site 266835001006 ATP binding site [chemical binding]; other site 266835001007 Q-loop/lid; other site 266835001008 ABC transporter signature motif; other site 266835001009 Walker B; other site 266835001010 D-loop; other site 266835001011 H-loop/switch region; other site 266835001012 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 266835001013 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 266835001014 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 266835001015 NADP binding site [chemical binding]; other site 266835001016 dimer interface [polypeptide binding]; other site 266835001017 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 266835001018 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 266835001019 Uncharacterized conserved protein [Function unknown]; Region: COG5588 266835001020 Predicted metal-binding integral membrane protein [Function unknown]; Region: COG5486 266835001021 Predicted metal-binding integral membrane protein (DUF2182); Region: DUF2182; pfam09948 266835001022 2-octaprenyl-6-methoxyphenyl hydroxylase; Provisional; Region: PRK07494 266835001023 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 266835001024 Uncharacterized conserved protein [Function unknown]; Region: COG3785 266835001025 Invasion protein B, involved in pathogenesis [General function prediction only]; Region: COG5342 266835001026 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 266835001027 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 266835001028 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 266835001029 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 266835001030 catalytic residues [active] 266835001031 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 266835001032 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 266835001033 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 266835001034 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 266835001035 MgtE intracellular N domain; Region: MgtE_N; pfam03448 266835001036 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 266835001037 Divalent cation transporter; Region: MgtE; pfam01769 266835001038 glutathione reductase; Validated; Region: PRK06116 266835001039 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 266835001040 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 266835001041 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3184 266835001042 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 266835001043 tetramer (dimer of dimers) interface [polypeptide binding]; other site 266835001044 active site 266835001045 dimer interface [polypeptide binding]; other site 266835001046 phosphoglycolate phosphatase; Provisional; Region: PRK13222 266835001047 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 266835001048 motif II; other site 266835001049 Uncharacterized protein conserved in bacteria, putative lipoprotein [Function unknown]; Region: LprI; COG4461 266835001050 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 266835001051 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989 266835001052 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 266835001053 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 266835001054 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835001055 NAD(P) binding site [chemical binding]; other site 266835001056 active site 266835001057 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266835001058 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266835001059 Polysulfide-sulfurtransferase - Rhodanese Homology Domain. This domain is believed to serve as a polysulfide binding and transferase domain in anaerobic gram-negative bacteria, functioning in oxidative phosphorylation with polysulfide-sulfur as a...; Region: Polysulfide_ST; cd01447 266835001060 active site 266835001061 catalytic residue [active] 266835001062 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 266835001063 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 266835001064 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 266835001065 MarR family; Region: MarR_2; pfam12802 266835001066 MarR family; Region: MarR_2; cl17246 266835001067 PPOX class probable FMN-dependent enzyme, DR_2398 family; Region: PPOX_FMN_DR2398; TIGR04025 266835001068 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3536 266835001069 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 266835001070 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 266835001071 FeS/SAM binding site; other site 266835001072 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 266835001073 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 266835001074 EamA-like transporter family; Region: EamA; pfam00892 266835001075 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 266835001076 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 266835001077 GTP binding site; other site 266835001078 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 266835001079 Walker A motif; other site 266835001080 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 266835001081 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 266835001082 substrate binding pocket [chemical binding]; other site 266835001083 membrane-bound complex binding site; other site 266835001084 hinge residues; other site 266835001085 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 266835001086 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835001087 dimer interface [polypeptide binding]; other site 266835001088 conserved gate region; other site 266835001089 putative PBP binding loops; other site 266835001090 ABC-ATPase subunit interface; other site 266835001091 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 266835001092 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835001093 dimer interface [polypeptide binding]; other site 266835001094 conserved gate region; other site 266835001095 putative PBP binding loops; other site 266835001096 ABC-ATPase subunit interface; other site 266835001097 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 266835001098 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 266835001099 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 266835001100 A new structural DNA glycosylase; Region: AlkD_like; cd06561 266835001101 active site 266835001102 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3495 266835001103 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 266835001104 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266835001105 putative DNA binding site [nucleotide binding]; other site 266835001106 putative Zn2+ binding site [ion binding]; other site 266835001107 AsnC family; Region: AsnC_trans_reg; pfam01037 266835001108 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033 266835001109 putative uracil binding site [chemical binding]; other site 266835001110 putative active site [active] 266835001111 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 266835001112 GST_N family, Saccharomyces cerevisiae GTT2-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT2. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing...; Region: GST_N_GTT2_like; cd03051 266835001113 putative C-terminal domain interface [polypeptide binding]; other site 266835001114 putative GSH binding site (G-site) [chemical binding]; other site 266835001115 putative dimer interface [polypeptide binding]; other site 266835001116 C-terminal, alpha helical domain of GTT2-like Glutathione S-transferases; Region: GST_C_GTT2_like; cd03182 266835001117 putative N-terminal domain interface [polypeptide binding]; other site 266835001118 putative dimer interface [polypeptide binding]; other site 266835001119 putative substrate binding pocket (H-site) [chemical binding]; other site 266835001120 Staphylococcal nuclease homologues; Region: SNc; smart00318 266835001121 Catalytic site; other site 266835001122 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 266835001123 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 266835001124 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266835001125 dimer interface [polypeptide binding]; other site 266835001126 phosphorylation site [posttranslational modification] 266835001127 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266835001128 ATP binding site [chemical binding]; other site 266835001129 Mg2+ binding site [ion binding]; other site 266835001130 G-X-G motif; other site 266835001131 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 266835001132 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 266835001133 putative dimer interface [polypeptide binding]; other site 266835001134 active site pocket [active] 266835001135 Protein of unknown function (DUF1289); Region: DUF1289; pfam06945 266835001136 Predicted aspartyl protease [General function prediction only]; Region: COG3577 266835001137 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 266835001138 catalytic motif [active] 266835001139 Catalytic residue [active] 266835001140 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 266835001141 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 266835001142 FMN binding site [chemical binding]; other site 266835001143 active site 266835001144 catalytic residues [active] 266835001145 substrate binding site [chemical binding]; other site 266835001146 Peptidase M4 family containing mostly uncharacterized proteins; Region: M4_uncharacterized; cd09598 266835001147 Zn binding site [ion binding]; other site 266835001148 Uncharacterized conserved protein [Function unknown]; Region: COG3482 266835001149 Uncharacterized conserved protein [Function unknown]; Region: COG1944 266835001150 YcaO-like family; Region: YcaO; pfam02624 266835001151 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 266835001152 cyclase homology domain; Region: CHD; cd07302 266835001153 nucleotidyl binding site; other site 266835001154 metal binding site [ion binding]; metal-binding site 266835001155 dimer interface [polypeptide binding]; other site 266835001156 Predicted ATPase [General function prediction only]; Region: COG3899 266835001157 AAA ATPase domain; Region: AAA_16; pfam13191 266835001158 Predicted ATPase [General function prediction only]; Region: COG3903 266835001159 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266835001160 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 266835001161 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 266835001162 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 266835001163 active site 266835001164 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532 266835001165 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 266835001166 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 266835001167 active site 266835001168 Domain of unknown function (DUF4347); Region: DUF4347; pfam14252 266835001169 Domain of unknown function (DUF4347); Region: DUF4347; pfam14252 266835001170 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 266835001171 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 266835001172 putative active site [active] 266835001173 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 266835001174 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266835001175 Walker A/P-loop; other site 266835001176 ATP binding site [chemical binding]; other site 266835001177 Q-loop/lid; other site 266835001178 ABC transporter signature motif; other site 266835001179 Walker B; other site 266835001180 D-loop; other site 266835001181 H-loop/switch region; other site 266835001182 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 266835001183 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 266835001184 HlyD family secretion protein; Region: HlyD_3; pfam13437 266835001185 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 266835001186 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 266835001187 Sel1-like repeats; Region: SEL1; smart00671 266835001188 Sel1-like repeats; Region: SEL1; smart00671 266835001189 Sel1-like repeats; Region: SEL1; smart00671 266835001190 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 266835001191 SPFH domain / Band 7 family; Region: Band_7; pfam01145 266835001192 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 266835001193 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 266835001194 Protein of unknown function (DUF982); Region: DUF982; pfam06169 266835001195 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 266835001196 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266835001197 Walker A/P-loop; other site 266835001198 ATP binding site [chemical binding]; other site 266835001199 Q-loop/lid; other site 266835001200 ABC transporter signature motif; other site 266835001201 Walker B; other site 266835001202 D-loop; other site 266835001203 H-loop/switch region; other site 266835001204 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 266835001205 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 266835001206 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266835001207 Walker A/P-loop; other site 266835001208 ATP binding site [chemical binding]; other site 266835001209 Q-loop/lid; other site 266835001210 ABC transporter signature motif; other site 266835001211 Walker B; other site 266835001212 D-loop; other site 266835001213 H-loop/switch region; other site 266835001214 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 266835001215 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 266835001216 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835001217 putative PBP binding loops; other site 266835001218 dimer interface [polypeptide binding]; other site 266835001219 ABC-ATPase subunit interface; other site 266835001220 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 266835001221 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 266835001222 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835001223 dimer interface [polypeptide binding]; other site 266835001224 conserved gate region; other site 266835001225 putative PBP binding loops; other site 266835001226 ABC-ATPase subunit interface; other site 266835001227 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 266835001228 The substrate-binding domain of an oligopeptide binding protein (OppA2) from the biosynthesis pathway of the beta-lactamase inhibitor clavulanic acid contains the type 2 periplasmic binding fold; Region: PBP2_clavulanate_OppA2; cd08506 266835001229 peptide binding site [polypeptide binding]; other site 266835001230 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 266835001231 Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260 266835001232 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 266835001233 interface (dimer of trimers) [polypeptide binding]; other site 266835001234 Substrate-binding/catalytic site; other site 266835001235 Zn-binding sites [ion binding]; other site 266835001236 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 266835001237 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266835001238 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266835001239 dimerization interface [polypeptide binding]; other site 266835001240 Cytosine/uracil/thiamine/allantoin permeases [Nucleotide transport and metabolism / Coenzyme metabolism]; Region: FUI1; COG1953 266835001241 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 266835001242 Na binding site [ion binding]; other site 266835001243 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3797 266835001244 CTP synthetase; Validated; Region: pyrG; PRK05380 266835001245 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 266835001246 Catalytic site [active] 266835001247 active site 266835001248 UTP binding site [chemical binding]; other site 266835001249 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 266835001250 active site 266835001251 putative oxyanion hole; other site 266835001252 catalytic triad [active] 266835001253 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 266835001254 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 266835001255 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 266835001256 triosephosphate isomerase; Provisional; Region: PRK14565 266835001257 substrate binding site [chemical binding]; other site 266835001258 dimer interface [polypeptide binding]; other site 266835001259 catalytic triad [active] 266835001260 SurA N-terminal domain; Region: SurA_N_3; cl07813 266835001261 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 266835001262 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 266835001263 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 266835001264 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 266835001265 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 266835001266 active site 266835001267 ribulose/triose binding site [chemical binding]; other site 266835001268 phosphate binding site [ion binding]; other site 266835001269 substrate (anthranilate) binding pocket [chemical binding]; other site 266835001270 product (indole) binding pocket [chemical binding]; other site 266835001271 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 266835001272 trimer interface [polypeptide binding]; other site 266835001273 dimer interface [polypeptide binding]; other site 266835001274 putative active site [active] 266835001275 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 266835001276 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 266835001277 dimer interface [polypeptide binding]; other site 266835001278 putative functional site; other site 266835001279 putative MPT binding site; other site 266835001280 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 266835001281 Protein of unknown function (DUF2974); Region: DUF2974; pfam11187 266835001282 2-aminobenzoate-CoA ligase (ABCL); Region: ABCL; cd05958 266835001283 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 266835001284 putative dimer interface [polypeptide binding]; other site 266835001285 acyl-activating enzyme (AAE) consensus motif; other site 266835001286 putative active site [active] 266835001287 putative AMP binding site [chemical binding]; other site 266835001288 putative CoA binding site [chemical binding]; other site 266835001289 putative chemical substrate binding site [chemical binding]; other site 266835001290 tryptophan 2,3-dioxygenase; Region: trp_2_3_diox; TIGR03036 266835001291 Kynureninase [Amino acid transport and metabolism]; Region: COG3844 266835001292 kynureninase; Region: kynureninase; TIGR01814 266835001293 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 266835001294 catalytic residue [active] 266835001295 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 266835001296 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 266835001297 TM-ABC transporter signature motif; other site 266835001298 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 266835001299 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266835001300 Walker A/P-loop; other site 266835001301 ATP binding site [chemical binding]; other site 266835001302 Q-loop/lid; other site 266835001303 ABC transporter signature motif; other site 266835001304 Walker B; other site 266835001305 D-loop; other site 266835001306 H-loop/switch region; other site 266835001307 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 266835001308 zinc binding site [ion binding]; other site 266835001309 putative ligand binding site [chemical binding]; other site 266835001310 Transcriptional regulators [Transcription]; Region: GntR; COG1802 266835001311 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266835001312 DNA-binding site [nucleotide binding]; DNA binding site 266835001313 FCD domain; Region: FCD; pfam07729 266835001314 LexA repressor; Validated; Region: PRK00215 266835001315 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 266835001316 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 266835001317 Catalytic site [active] 266835001318 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 266835001319 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 266835001320 Competence protein; Region: Competence; pfam03772 266835001321 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 266835001322 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 266835001323 active site 266835001324 HIGH motif; other site 266835001325 nucleotide binding site [chemical binding]; other site 266835001326 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 266835001327 active site 266835001328 KMSKS motif; other site 266835001329 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 266835001330 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 266835001331 dimer interface [polypeptide binding]; other site 266835001332 active site 266835001333 citrylCoA binding site [chemical binding]; other site 266835001334 NADH binding [chemical binding]; other site 266835001335 cationic pore residues; other site 266835001336 oxalacetate/citrate binding site [chemical binding]; other site 266835001337 coenzyme A binding site [chemical binding]; other site 266835001338 catalytic triad [active] 266835001339 Lipid A disaccharide synthetase [Cell envelope biogenesis, outer membrane]; Region: LpxB; COG0763 266835001340 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 266835001341 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3494 266835001342 Acyl-[acyl carrier protein]; Region: LpxA; COG1043 266835001343 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 266835001344 active site 266835001345 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 266835001346 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 266835001347 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 266835001348 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 266835001349 trimer interface [polypeptide binding]; other site 266835001350 active site 266835001351 UDP-GlcNAc binding site [chemical binding]; other site 266835001352 lipid binding site [chemical binding]; lipid-binding site 266835001353 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 266835001354 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 266835001355 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 266835001356 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 266835001357 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 266835001358 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 266835001359 Surface antigen; Region: Bac_surface_Ag; pfam01103 266835001360 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 266835001361 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 266835001362 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 266835001363 protein binding site [polypeptide binding]; other site 266835001364 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 266835001365 putative substrate binding region [chemical binding]; other site 266835001366 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 266835001367 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 266835001368 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 266835001369 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 266835001370 catalytic residue [active] 266835001371 putative FPP diphosphate binding site; other site 266835001372 putative FPP binding hydrophobic cleft; other site 266835001373 dimer interface [polypeptide binding]; other site 266835001374 putative IPP diphosphate binding site; other site 266835001375 ribosome recycling factor; Reviewed; Region: frr; PRK00083 266835001376 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 266835001377 hinge region; other site 266835001378 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 266835001379 putative nucleotide binding site [chemical binding]; other site 266835001380 uridine monophosphate binding site [chemical binding]; other site 266835001381 homohexameric interface [polypeptide binding]; other site 266835001382 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 266835001383 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 266835001384 active site 266835001385 catalytic tetrad [active] 266835001386 SnoaL-like domain; Region: SnoaL_4; pfam13577 266835001387 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266835001388 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266835001389 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 266835001390 putative effector binding pocket; other site 266835001391 putative dimerization interface [polypeptide binding]; other site 266835001392 elongation factor Ts; Provisional; Region: tsf; PRK09377 266835001393 UBA/TS-N domain; Region: UBA; pfam00627 266835001394 Elongation factor TS; Region: EF_TS; pfam00889 266835001395 Elongation factor TS; Region: EF_TS; pfam00889 266835001396 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 266835001397 rRNA interaction site [nucleotide binding]; other site 266835001398 S8 interaction site; other site 266835001399 putative laminin-1 binding site; other site 266835001400 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 266835001401 Protein of unknown function (DUF4031); Region: DUF4031; pfam13223 266835001402 Domain of unknown function (DUF1849); Region: DUF1849; pfam08904 266835001403 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 266835001404 homotrimer interaction site [polypeptide binding]; other site 266835001405 putative active site [active] 266835001406 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_3; cd08585 266835001407 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 266835001408 putative active site [active] 266835001409 catalytic site [active] 266835001410 putative metal binding site [ion binding]; other site 266835001411 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3146 266835001412 Protein of unknown function, DUF482; Region: DUF482; pfam04339 266835001413 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 266835001414 HIT family signature motif; other site 266835001415 catalytic residue [active] 266835001416 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 266835001417 Clp amino terminal domain; Region: Clp_N; pfam02861 266835001418 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266835001419 Walker A motif; other site 266835001420 ATP binding site [chemical binding]; other site 266835001421 Walker B motif; other site 266835001422 arginine finger; other site 266835001423 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266835001424 Walker A motif; other site 266835001425 ATP binding site [chemical binding]; other site 266835001426 Walker B motif; other site 266835001427 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 266835001428 Uncharacterized conserved protein [Function unknown]; Region: COG2127 266835001429 Phasin protein; Region: Phasin_2; pfam09361 266835001430 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 266835001431 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 266835001432 Sporulation related domain; Region: SPOR; pfam05036 266835001433 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 266835001434 HSP70 interaction site [polypeptide binding]; other site 266835001435 Uncharacterized conserved protein [Function unknown]; Region: COG5458 266835001436 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 266835001437 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 266835001438 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 266835001439 Predicted membrane protein [Function unknown]; Region: COG3821 266835001440 Uncharacterized conserved protein [Function unknown]; Region: COG1434 266835001441 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 266835001442 putative active site [active] 266835001443 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 266835001444 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 266835001445 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 266835001446 Coenzyme A binding pocket [chemical binding]; other site 266835001447 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 266835001448 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 266835001449 metal-dependent hydrolase; Provisional; Region: PRK00685 266835001450 Predicted endonuclease involved in recombination (possible Holliday junction resolvase in Mycoplasmas and B. subtilis) [DNA replication, recombination, and repair]; Region: COG0816 266835001451 Proteins involved in DNA damage response, similar to the AidB gene product; Region: AidB; cd01154 266835001452 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 266835001453 FAD binding site [chemical binding]; other site 266835001454 substrate binding site [chemical binding]; other site 266835001455 catalytic residues [active] 266835001456 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 266835001457 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 266835001458 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 266835001459 dihydroorotase; Validated; Region: PRK09059 266835001460 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 266835001461 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 266835001462 active site 266835001463 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 266835001464 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 266835001465 DNA protecting protein DprA; Region: dprA; TIGR00732 266835001466 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 266835001467 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 266835001468 Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380 266835001469 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 266835001470 active site 266835001471 homotetramer interface [polypeptide binding]; other site 266835001472 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 266835001473 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 266835001474 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 266835001475 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 266835001476 putative ADP-binding pocket [chemical binding]; other site 266835001477 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 266835001478 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 266835001479 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 266835001480 BA14K-like protein; Region: BA14K; pfam07886 266835001481 Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554 266835001482 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 266835001483 N- and C-terminal domain interface [polypeptide binding]; other site 266835001484 active site 266835001485 MgATP binding site [chemical binding]; other site 266835001486 catalytic site [active] 266835001487 metal binding site [ion binding]; metal-binding site 266835001488 glycerol binding site [chemical binding]; other site 266835001489 homotetramer interface [polypeptide binding]; other site 266835001490 homodimer interface [polypeptide binding]; other site 266835001491 FBP binding site [chemical binding]; other site 266835001492 protein IIAGlc interface [polypeptide binding]; other site 266835001493 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 266835001494 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 266835001495 Predicted small integral membrane protein [Function unknown]; Region: COG5477 266835001496 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 266835001497 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835001498 dimer interface [polypeptide binding]; other site 266835001499 conserved gate region; other site 266835001500 putative PBP binding loops; other site 266835001501 ABC-ATPase subunit interface; other site 266835001502 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835001503 dimer interface [polypeptide binding]; other site 266835001504 conserved gate region; other site 266835001505 putative PBP binding loops; other site 266835001506 ABC-ATPase subunit interface; other site 266835001507 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 266835001508 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 266835001509 Walker A/P-loop; other site 266835001510 ATP binding site [chemical binding]; other site 266835001511 Q-loop/lid; other site 266835001512 ABC transporter signature motif; other site 266835001513 Walker B; other site 266835001514 D-loop; other site 266835001515 H-loop/switch region; other site 266835001516 TOBE domain; Region: TOBE_2; pfam08402 266835001517 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 266835001518 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 266835001519 Walker A/P-loop; other site 266835001520 ATP binding site [chemical binding]; other site 266835001521 Q-loop/lid; other site 266835001522 ABC transporter signature motif; other site 266835001523 Walker B; other site 266835001524 D-loop; other site 266835001525 H-loop/switch region; other site 266835001526 TOBE domain; Region: TOBE_2; pfam08402 266835001527 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 266835001528 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl17341 266835001529 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 266835001530 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 266835001531 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 266835001532 tyrosine decarboxylase; Region: PLN02880 266835001533 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 266835001534 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 266835001535 catalytic residue [active] 266835001536 Predicted proteasome-type protease [Posttranslational modification, protein turnover, chaperones]; Region: COG3484 266835001537 Bacterial proteasome, beta subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that...; Region: proteasome_beta_bacterial; cd03765 266835001538 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 266835001539 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 266835001540 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 266835001541 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 266835001542 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 266835001543 Uncharacterized conserved protein [Function unknown]; Region: COG2308 266835001544 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 266835001545 AsnC family; Region: AsnC_trans_reg; pfam01037 266835001546 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 266835001547 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 266835001548 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 266835001549 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 266835001550 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 266835001551 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 266835001552 active site 266835001553 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 266835001554 active site 266835001555 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 266835001556 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 266835001557 active site 266835001558 (T/H)XGH motif; other site 266835001559 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 266835001560 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 266835001561 CAP-like domain; other site 266835001562 active site 266835001563 primary dimer interface [polypeptide binding]; other site 266835001564 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 266835001565 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 266835001566 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 266835001567 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 266835001568 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 266835001569 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 266835001570 Sulfate transporter family; Region: Sulfate_transp; pfam00916 266835001571 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 266835001572 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4318 266835001573 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266835001574 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 266835001575 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266835001576 Acyltransferase family; Region: Acyl_transf_3; pfam01757 266835001577 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 266835001578 OsmC-like protein; Region: OsmC; cl00767 266835001579 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 266835001580 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 266835001581 dimer interface [polypeptide binding]; other site 266835001582 ssDNA binding site [nucleotide binding]; other site 266835001583 tetramer (dimer of dimers) interface [polypeptide binding]; other site 266835001584 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266835001585 dimerization interface [polypeptide binding]; other site 266835001586 putative DNA binding site [nucleotide binding]; other site 266835001587 putative Zn2+ binding site [ion binding]; other site 266835001588 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 266835001589 putative hydrophobic ligand binding site [chemical binding]; other site 266835001590 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 266835001591 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 266835001592 oligomer interface [polypeptide binding]; other site 266835001593 active site residues [active] 266835001594 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 266835001595 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 266835001596 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 266835001597 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 266835001598 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 266835001599 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 266835001600 Coenzyme A binding pocket [chemical binding]; other site 266835001601 Uncharacterized conserved protein [Function unknown]; Region: COG1801 266835001602 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 266835001603 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266835001604 metal binding site [ion binding]; metal-binding site 266835001605 active site 266835001606 I-site; other site 266835001607 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 266835001608 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 266835001609 Walker A/P-loop; other site 266835001610 ATP binding site [chemical binding]; other site 266835001611 Q-loop/lid; other site 266835001612 ABC transporter signature motif; other site 266835001613 Walker B; other site 266835001614 D-loop; other site 266835001615 H-loop/switch region; other site 266835001616 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 266835001617 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 266835001618 Walker A/P-loop; other site 266835001619 ATP binding site [chemical binding]; other site 266835001620 Q-loop/lid; other site 266835001621 ABC transporter signature motif; other site 266835001622 Walker B; other site 266835001623 D-loop; other site 266835001624 H-loop/switch region; other site 266835001625 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 266835001626 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 266835001627 TM-ABC transporter signature motif; other site 266835001628 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 266835001629 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 266835001630 TM-ABC transporter signature motif; other site 266835001631 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 266835001632 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 266835001633 putative ligand binding site [chemical binding]; other site 266835001634 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 266835001635 TAT (twin-arginine translocation) pathway signal sequence; Region: TAT_signal; pfam10518 266835001636 Purine-nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: DeoD; COG0813 266835001637 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 266835001638 PAS domain; Region: PAS; smart00091 266835001639 PAS domain; Region: PAS_9; pfam13426 266835001640 PAS domain; Region: PAS; smart00091 266835001641 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 266835001642 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266835001643 dimer interface [polypeptide binding]; other site 266835001644 phosphorylation site [posttranslational modification] 266835001645 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266835001646 ATP binding site [chemical binding]; other site 266835001647 Mg2+ binding site [ion binding]; other site 266835001648 G-X-G motif; other site 266835001649 Response regulator receiver domain; Region: Response_reg; pfam00072 266835001650 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266835001651 active site 266835001652 phosphorylation site [posttranslational modification] 266835001653 intermolecular recognition site; other site 266835001654 dimerization interface [polypeptide binding]; other site 266835001655 RNA polymerase-binding protein DksA; Region: dksA; TIGR02420 266835001656 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 266835001657 catalytic core [active] 266835001658 Predicted ATPase [General function prediction only]; Region: COG3106 266835001659 Predicted membrane protein [Function unknown]; Region: COG3768 266835001660 Domain of unknown function (DUF697); Region: DUF697; cl12064 266835001661 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 266835001662 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 266835001663 Cupin; Region: Cupin_6; pfam12852 266835001664 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266835001665 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 266835001666 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266835001667 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 266835001668 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 266835001669 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 266835001670 TrkA-N domain; Region: TrkA_N; pfam02254 266835001671 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3803 266835001672 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 266835001673 catalytic center binding site [active] 266835001674 ATP binding site [chemical binding]; other site 266835001675 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 266835001676 homooctamer interface [polypeptide binding]; other site 266835001677 active site 266835001678 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 266835001679 dihydropteroate synthase; Region: DHPS; TIGR01496 266835001680 substrate binding pocket [chemical binding]; other site 266835001681 dimer interface [polypeptide binding]; other site 266835001682 inhibitor binding site; inhibition site 266835001683 Predicted secreted Zn-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5661 266835001684 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266835001685 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 266835001686 putative substrate translocation pore; other site 266835001687 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 266835001688 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 266835001689 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 266835001690 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 266835001691 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 266835001692 catalytic loop [active] 266835001693 iron binding site [ion binding]; other site 266835001694 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 266835001695 ABC-type uncharacterized transport system, auxiliary component [General function prediction only]; Region: COG3218 266835001696 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 266835001697 mce related protein; Region: MCE; pfam02470 266835001698 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 266835001699 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266835001700 Walker A/P-loop; other site 266835001701 ATP binding site [chemical binding]; other site 266835001702 Q-loop/lid; other site 266835001703 ABC transporter signature motif; other site 266835001704 Walker B; other site 266835001705 D-loop; other site 266835001706 H-loop/switch region; other site 266835001707 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 266835001708 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 266835001709 Permease; Region: Permease; pfam02405 266835001710 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 266835001711 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 266835001712 active site 266835001713 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 266835001714 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266835001715 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 266835001716 putative active site [active] 266835001717 putative metal binding site [ion binding]; other site 266835001718 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 266835001719 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 266835001720 putative NAD(P) binding site [chemical binding]; other site 266835001721 putative active site [active] 266835001722 malic enzyme; Reviewed; Region: PRK12862 266835001723 Malic enzyme, N-terminal domain; Region: malic; pfam00390 266835001724 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 266835001725 putative NAD(P) binding site [chemical binding]; other site 266835001726 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 266835001727 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 266835001728 Protein of unknown function (DUF2865); Region: DUF2865; pfam11064 266835001729 glutamyl-tRNA synthetase; Provisional; Region: PRK12558 266835001730 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 266835001731 HIGH motif; other site 266835001732 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 266835001733 active site 266835001734 KMSKS motif; other site 266835001735 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 266835001736 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 266835001737 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 266835001738 Walker A/P-loop; other site 266835001739 ATP binding site [chemical binding]; other site 266835001740 Q-loop/lid; other site 266835001741 ABC transporter signature motif; other site 266835001742 Walker B; other site 266835001743 D-loop; other site 266835001744 H-loop/switch region; other site 266835001745 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 266835001746 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 266835001747 Coenzyme A binding pocket [chemical binding]; other site 266835001748 NAD synthetase; Provisional; Region: PRK13981 266835001749 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 266835001750 multimer interface [polypeptide binding]; other site 266835001751 active site 266835001752 catalytic triad [active] 266835001753 protein interface 1 [polypeptide binding]; other site 266835001754 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 266835001755 homodimer interface [polypeptide binding]; other site 266835001756 NAD binding pocket [chemical binding]; other site 266835001757 ATP binding pocket [chemical binding]; other site 266835001758 Mg binding site [ion binding]; other site 266835001759 active-site loop [active] 266835001760 3-methyladenine DNA glycosylase [DNA replication, recombination, and repair]; Region: Tag; COG2818 266835001761 Predicted membrane protein [Function unknown]; Region: COG4420 266835001762 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 266835001763 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 266835001764 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 266835001765 Uncharacterized conserved protein [Function unknown]; Region: COG3791 266835001766 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 266835001767 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266835001768 metal binding site [ion binding]; metal-binding site 266835001769 active site 266835001770 I-site; other site 266835001771 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 266835001772 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 266835001773 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 266835001774 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 266835001775 ATP binding site [chemical binding]; other site 266835001776 putative Mg++ binding site [ion binding]; other site 266835001777 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 266835001778 nucleotide binding region [chemical binding]; other site 266835001779 ATP-binding site [chemical binding]; other site 266835001780 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 266835001781 Uncharacterized conserved protein [Function unknown]; Region: COG2938 266835001782 RecG-like helicase [DNA replication, recombination, and repair / Transcription]; Region: RecG; COG1200 266835001783 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 266835001784 generic binding surface II; other site 266835001785 ssDNA binding site; other site 266835001786 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 266835001787 ATP binding site [chemical binding]; other site 266835001788 putative Mg++ binding site [ion binding]; other site 266835001789 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 266835001790 nucleotide binding region [chemical binding]; other site 266835001791 ATP-binding site [chemical binding]; other site 266835001792 Uncharacterized conserved protein [Function unknown]; Region: COG2928 266835001793 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 266835001794 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 266835001795 glutaminase active site [active] 266835001796 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 266835001797 dimer interface [polypeptide binding]; other site 266835001798 active site 266835001799 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 266835001800 dimer interface [polypeptide binding]; other site 266835001801 active site 266835001802 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14353 266835001803 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 266835001804 Substrate binding site; other site 266835001805 Mg++ binding site; other site 266835001806 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 266835001807 active site 266835001808 substrate binding site [chemical binding]; other site 266835001809 CoA binding site [chemical binding]; other site 266835001810 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 266835001811 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 266835001812 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 266835001813 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 266835001814 active site 266835001815 interdomain interaction site; other site 266835001816 putative metal-binding site [ion binding]; other site 266835001817 nucleotide binding site [chemical binding]; other site 266835001818 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 266835001819 domain I; other site 266835001820 DNA binding groove [nucleotide binding] 266835001821 phosphate binding site [ion binding]; other site 266835001822 domain II; other site 266835001823 domain III; other site 266835001824 nucleotide binding site [chemical binding]; other site 266835001825 catalytic site [active] 266835001826 domain IV; other site 266835001827 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 266835001828 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 266835001829 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 266835001830 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 266835001831 ribonuclease R; Region: RNase_R; TIGR02063 266835001832 RNB domain; Region: RNB; pfam00773 266835001833 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 266835001834 RNA binding site [nucleotide binding]; other site 266835001835 hypothetical protein; Provisional; Region: PRK05978 266835001836 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 266835001837 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266835001838 putative substrate translocation pore; other site 266835001839 Major Facilitator Superfamily; Region: MFS_1; pfam07690 266835001840 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 266835001841 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 266835001842 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 266835001843 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 266835001844 Walker A/P-loop; other site 266835001845 ATP binding site [chemical binding]; other site 266835001846 Q-loop/lid; other site 266835001847 ABC transporter signature motif; other site 266835001848 Walker B; other site 266835001849 D-loop; other site 266835001850 H-loop/switch region; other site 266835001851 TOBE domain; Region: TOBE_2; pfam08402 266835001852 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 266835001853 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835001854 dimer interface [polypeptide binding]; other site 266835001855 conserved gate region; other site 266835001856 putative PBP binding loops; other site 266835001857 ABC-ATPase subunit interface; other site 266835001858 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835001859 dimer interface [polypeptide binding]; other site 266835001860 conserved gate region; other site 266835001861 putative PBP binding loops; other site 266835001862 ABC-ATPase subunit interface; other site 266835001863 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 266835001864 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 266835001865 hypothetical protein; Provisional; Region: PRK05968 266835001866 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 266835001867 homodimer interface [polypeptide binding]; other site 266835001868 substrate-cofactor binding pocket; other site 266835001869 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266835001870 catalytic residue [active] 266835001871 Transcriptional regulators [Transcription]; Region: FadR; COG2186 266835001872 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266835001873 DNA-binding site [nucleotide binding]; DNA binding site 266835001874 FCD domain; Region: FCD; pfam07729 266835001875 hypothetical protein; Provisional; Region: PRK06834 266835001876 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 266835001877 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 266835001878 Poly A polymerase head domain; Region: PolyA_pol; pfam01743 266835001879 response regulator PleD; Reviewed; Region: pleD; PRK09581 266835001880 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266835001881 active site 266835001882 phosphorylation site [posttranslational modification] 266835001883 intermolecular recognition site; other site 266835001884 dimerization interface [polypeptide binding]; other site 266835001885 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266835001886 metal binding site [ion binding]; metal-binding site 266835001887 active site 266835001888 I-site; other site 266835001889 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 266835001890 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266835001891 active site 266835001892 phosphorylation site [posttranslational modification] 266835001893 intermolecular recognition site; other site 266835001894 dimerization interface [polypeptide binding]; other site 266835001895 Protein of unknown function (DUF3572); Region: DUF3572; pfam12096 266835001896 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 266835001897 hypothetical protein; Provisional; Region: 30.2; PHA02597 266835001898 DNA polymerase IV; Provisional; Region: PRK02794 266835001899 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 266835001900 active site 266835001901 DNA binding site [nucleotide binding] 266835001902 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 266835001903 EamA-like transporter family; Region: EamA; pfam00892 266835001904 Ion channel; Region: Ion_trans_2; pfam07885 266835001905 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 266835001906 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 266835001907 putative active site [active] 266835001908 putative PHP Thumb interface [polypeptide binding]; other site 266835001909 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 266835001910 generic binding surface II; other site 266835001911 generic binding surface I; other site 266835001912 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 266835001913 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 266835001914 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 266835001915 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 266835001916 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 266835001917 carboxyltransferase (CT) interaction site; other site 266835001918 biotinylation site [posttranslational modification]; other site 266835001919 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 266835001920 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 266835001921 substrate binding site [chemical binding]; other site 266835001922 catalytic Zn binding site [ion binding]; other site 266835001923 NAD binding site [chemical binding]; other site 266835001924 structural Zn binding site [ion binding]; other site 266835001925 dimer interface [polypeptide binding]; other site 266835001926 glutathione-dependent formaldehyde-activating enzyme; Provisional; Region: PRK05417 266835001927 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1671 266835001928 Predicted membrane protein [Function unknown]; Region: COG4291 266835001929 Prokaryotic cytochrome b561; Region: Ni_hydr_CYTB; pfam01292 266835001930 Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117 266835001931 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033 266835001932 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 266835001933 bacterial subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. This domain is found in a variety of oxidoreductases. Common features of all known members of this family, like sulfite oxidase and nitrite reductase, are that they...; Region: bact_SO_family_Moco; cd02108 266835001934 Moco binding site; other site 266835001935 metal coordination site [ion binding]; other site 266835001936 glycine cleavage system aminomethyltransferase T; Provisional; Region: gcvT; PRK13579 266835001937 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 266835001938 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 266835001939 lipoyl attachment site [posttranslational modification]; other site 266835001940 glycine dehydrogenase; Provisional; Region: PRK05367 266835001941 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 266835001942 tetramer interface [polypeptide binding]; other site 266835001943 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266835001944 catalytic residue [active] 266835001945 Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG1003 266835001946 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 266835001947 catalytic residue [active] 266835001948 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 266835001949 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266835001950 metal binding site [ion binding]; metal-binding site 266835001951 active site 266835001952 I-site; other site 266835001953 Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking and secretion]; Region: TadD; COG5010 266835001954 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266835001955 binding surface 266835001956 TPR motif; other site 266835001957 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 266835001958 LytTr DNA-binding domain; Region: LytTR; smart00850 266835001959 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 266835001960 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 266835001961 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 266835001962 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 266835001963 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 266835001964 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 266835001965 ATP binding site [chemical binding]; other site 266835001966 Walker A motif; other site 266835001967 hexamer interface [polypeptide binding]; other site 266835001968 Walker B motif; other site 266835001969 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 266835001970 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 266835001971 Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964 266835001972 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 266835001973 BON domain; Region: BON; pfam04972 266835001974 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 266835001975 Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745 266835001976 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 266835001977 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 266835001978 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266835001979 Mg2+ binding site [ion binding]; other site 266835001980 G-X-G motif; other site 266835001981 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 266835001982 anchoring element; other site 266835001983 dimer interface [polypeptide binding]; other site 266835001984 ATP binding site [chemical binding]; other site 266835001985 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 266835001986 active site 266835001987 metal binding site [ion binding]; metal-binding site 266835001988 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 266835001989 Fusaric acid resistance protein family; Region: FUSC; pfam04632 266835001990 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 266835001991 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 266835001992 putative active site [active] 266835001993 putative catalytic site [active] 266835001994 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 266835001995 Protein of unknown function (DUF1012); Region: DUF1012; pfam06241 266835001996 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 266835001997 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266835001998 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266835001999 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 266835002000 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 266835002001 putative FMN binding site [chemical binding]; other site 266835002002 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ACT14924; Region: LPLAT_ACT14924-like; cd07986 266835002003 putative acyl-acceptor binding pocket; other site 266835002004 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 266835002005 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 266835002006 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 266835002007 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 266835002008 active site 266835002009 dimer interface [polypeptide binding]; other site 266835002010 motif 1; other site 266835002011 motif 2; other site 266835002012 motif 3; other site 266835002013 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 266835002014 anticodon binding site; other site 266835002015 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 266835002016 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 266835002017 Beta-lactamase class D [Defense mechanisms]; Region: COG2602 266835002018 hypothetical protein; Validated; Region: PRK00041 266835002019 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 266835002020 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266835002021 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 266835002022 dimerization interface [polypeptide binding]; other site 266835002023 substrate binding pocket [chemical binding]; other site 266835002024 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 266835002025 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 266835002026 trimerization site [polypeptide binding]; other site 266835002027 active site 266835002028 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 266835002029 GTP cyclohydrolase I; Provisional; Region: PLN03044 266835002030 active site 266835002031 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 266835002032 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 266835002033 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 266835002034 active site 266835002035 nucleophile elbow; other site 266835002036 RibD C-terminal domain; Region: RibD_C; pfam01872 266835002037 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 266835002038 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 266835002039 DHH family; Region: DHH; pfam01368 266835002040 DHHA1 domain; Region: DHHA1; pfam02272 266835002041 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 266835002042 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 266835002043 putative active site [active] 266835002044 Bacterial protein of unknown function (DUF883); Region: DUF883; pfam05957 266835002045 homoserine dehydrogenase; Provisional; Region: PRK06349 266835002046 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 266835002047 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 266835002048 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 266835002049 aminotransferase; Validated; Region: PRK09148 266835002050 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 266835002051 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266835002052 homodimer interface [polypeptide binding]; other site 266835002053 catalytic residue [active] 266835002054 poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838 266835002055 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 266835002056 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 266835002057 Peptidase M15; Region: Peptidase_M15_3; cl01194 266835002058 SnoaL-like domain; Region: SnoaL_2; pfam12680 266835002059 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 266835002060 HSP70 interaction site [polypeptide binding]; other site 266835002061 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 266835002062 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 266835002063 TadE-like protein; Region: TadE; pfam07811 266835002064 Uncharacterized protein with a C-terminal OMP (outer membrane protein) domain [Function unknown]; Region: COG4625 266835002065 Autotransporter beta-domain; Region: Autotransporter; smart00869 266835002066 Protein of unknown function (DUF982); Region: DUF982; pfam06169 266835002067 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 266835002068 active site 266835002069 hypothetical protein; Reviewed; Region: PRK00024 266835002070 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 266835002071 MPN+ (JAMM) motif; other site 266835002072 Zinc-binding site [ion binding]; other site 266835002073 Domain of unknown function (DUF4102); Region: DUF4102; pfam13356 266835002074 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 266835002075 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 266835002076 active site 266835002077 DNA binding site [nucleotide binding] 266835002078 Int/Topo IB signature motif; other site 266835002079 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266835002080 non-specific DNA binding site [nucleotide binding]; other site 266835002081 salt bridge; other site 266835002082 sequence-specific DNA binding site [nucleotide binding]; other site 266835002083 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 266835002084 Acyltransferase family; Region: Acyl_transf_3; pfam01757 266835002085 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 266835002086 conjugal transfer relaxase TraA; Provisional; Region: PRK13889 266835002087 MobA/MobL family; Region: MobA_MobL; pfam03389 266835002088 AAA domain; Region: AAA_30; pfam13604 266835002089 Family description; Region: UvrD_C_2; pfam13538 266835002090 Conjugal transfer protein TraD; Region: TraD; pfam06412 266835002091 allantoate amidohydrolase; Reviewed; Region: PRK12892 266835002092 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 266835002093 active site 266835002094 metal binding site [ion binding]; metal-binding site 266835002095 dimer interface [polypeptide binding]; other site 266835002096 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 266835002097 Transposase; Region: DEDD_Tnp_IS110; pfam01548 266835002098 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 266835002099 ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416 266835002100 [2Fe-2S] cluster binding site [ion binding]; other site 266835002101 cytochrome b; Provisional; Region: CYTB; MTH00119 266835002102 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 266835002103 Qi binding site; other site 266835002104 intrachain domain interface; other site 266835002105 interchain domain interface [polypeptide binding]; other site 266835002106 heme bH binding site [chemical binding]; other site 266835002107 heme bL binding site [chemical binding]; other site 266835002108 Qo binding site; other site 266835002109 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290 266835002110 interchain domain interface [polypeptide binding]; other site 266835002111 intrachain domain interface; other site 266835002112 Qi binding site; other site 266835002113 Qo binding site; other site 266835002114 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 266835002115 Mechanosensitive ion channel; Region: MS_channel; pfam00924 266835002116 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 266835002117 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 266835002118 ligand binding site [chemical binding]; other site 266835002119 flexible hinge region; other site 266835002120 Pirin-related protein [General function prediction only]; Region: COG1741 266835002121 Pirin; Region: Pirin; pfam02678 266835002122 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 266835002123 Uncharacterized conserved protein [Function unknown]; Region: COG5579 266835002124 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 266835002125 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266835002126 ATP binding site [chemical binding]; other site 266835002127 Mg2+ binding site [ion binding]; other site 266835002128 G-X-G motif; other site 266835002129 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 266835002130 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835002131 NAD(P) binding site [chemical binding]; other site 266835002132 active site 266835002133 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 266835002134 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 266835002135 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 266835002136 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 266835002137 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_6; cd04619 266835002138 FOG: CBS domain [General function prediction only]; Region: COG0517 266835002139 glutathionine S-transferase; Provisional; Region: PRK10542 266835002140 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 266835002141 C-terminal domain interface [polypeptide binding]; other site 266835002142 GSH binding site (G-site) [chemical binding]; other site 266835002143 dimer interface [polypeptide binding]; other site 266835002144 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 266835002145 dimer interface [polypeptide binding]; other site 266835002146 N-terminal domain interface [polypeptide binding]; other site 266835002147 substrate binding pocket (H-site) [chemical binding]; other site 266835002148 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 266835002149 Zn2+ binding site [ion binding]; other site 266835002150 Mg2+ binding site [ion binding]; other site 266835002151 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 266835002152 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266835002153 active site 266835002154 phosphorylation site [posttranslational modification] 266835002155 intermolecular recognition site; other site 266835002156 dimerization interface [polypeptide binding]; other site 266835002157 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266835002158 DNA binding residues [nucleotide binding] 266835002159 dimerization interface [polypeptide binding]; other site 266835002160 Predicted integral membrane sensor domain [Signal transduction mechanisms]; Region: COG3447 266835002161 PAS fold; Region: PAS; pfam00989 266835002162 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266835002163 putative active site [active] 266835002164 heme pocket [chemical binding]; other site 266835002165 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266835002166 PAS domain; Region: PAS_9; pfam13426 266835002167 putative active site [active] 266835002168 heme pocket [chemical binding]; other site 266835002169 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266835002170 PAS domain; Region: PAS_9; pfam13426 266835002171 putative active site [active] 266835002172 heme pocket [chemical binding]; other site 266835002173 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 266835002174 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266835002175 ATP binding site [chemical binding]; other site 266835002176 Mg2+ binding site [ion binding]; other site 266835002177 G-X-G motif; other site 266835002178 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 266835002179 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 266835002180 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 266835002181 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266835002182 Walker A/P-loop; other site 266835002183 ATP binding site [chemical binding]; other site 266835002184 Q-loop/lid; other site 266835002185 ABC transporter signature motif; other site 266835002186 Walker B; other site 266835002187 D-loop; other site 266835002188 H-loop/switch region; other site 266835002189 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 266835002190 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266835002191 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 266835002192 Walker A/P-loop; other site 266835002193 ATP binding site [chemical binding]; other site 266835002194 Q-loop/lid; other site 266835002195 ABC transporter signature motif; other site 266835002196 Walker B; other site 266835002197 D-loop; other site 266835002198 H-loop/switch region; other site 266835002199 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 266835002200 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 266835002201 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835002202 dimer interface [polypeptide binding]; other site 266835002203 conserved gate region; other site 266835002204 putative PBP binding loops; other site 266835002205 ABC-ATPase subunit interface; other site 266835002206 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 266835002207 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 266835002208 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266835002209 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 266835002210 putative active site [active] 266835002211 heme pocket [chemical binding]; other site 266835002212 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266835002213 putative active site [active] 266835002214 heme pocket [chemical binding]; other site 266835002215 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 266835002216 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 266835002217 dimer interface [polypeptide binding]; other site 266835002218 phosphorylation site [posttranslational modification] 266835002219 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266835002220 ATP binding site [chemical binding]; other site 266835002221 Mg2+ binding site [ion binding]; other site 266835002222 G-X-G motif; other site 266835002223 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 266835002224 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266835002225 active site 266835002226 phosphorylation site [posttranslational modification] 266835002227 intermolecular recognition site; other site 266835002228 dimerization interface [polypeptide binding]; other site 266835002229 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266835002230 DNA binding residues [nucleotide binding] 266835002231 dimerization interface [polypeptide binding]; other site 266835002232 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 266835002233 heme-binding site [chemical binding]; other site 266835002234 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 266835002235 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 266835002236 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266835002237 putative substrate translocation pore; other site 266835002238 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266835002239 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 266835002240 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 266835002241 HlyD family secretion protein; Region: HlyD_3; pfam13437 266835002242 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266835002243 ATP binding site [chemical binding]; other site 266835002244 Mg2+ binding site [ion binding]; other site 266835002245 G-X-G motif; other site 266835002246 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 266835002247 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 266835002248 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 266835002249 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 266835002250 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 266835002251 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 266835002252 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 266835002253 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 266835002254 Walker A/P-loop; other site 266835002255 ATP binding site [chemical binding]; other site 266835002256 Q-loop/lid; other site 266835002257 ABC transporter signature motif; other site 266835002258 Walker B; other site 266835002259 D-loop; other site 266835002260 H-loop/switch region; other site 266835002261 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 266835002262 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 266835002263 TM-ABC transporter signature motif; other site 266835002264 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312 266835002265 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 266835002266 putative ligand binding site [chemical binding]; other site 266835002267 Transcriptional regulators [Transcription]; Region: PurR; COG1609 266835002268 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 266835002269 DNA binding site [nucleotide binding] 266835002270 domain linker motif; other site 266835002271 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_2; cd06278 266835002272 putative ligand binding site [chemical binding]; other site 266835002273 putative dimerization interface [polypeptide binding]; other site 266835002274 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 266835002275 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 266835002276 choline dehydrogenase; Validated; Region: PRK02106 266835002277 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 266835002278 enoyl-CoA hydratase-isomerase; Provisional; Region: PRK09674 266835002279 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266835002280 substrate binding site [chemical binding]; other site 266835002281 oxyanion hole (OAH) forming residues; other site 266835002282 trimer interface [polypeptide binding]; other site 266835002283 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 266835002284 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 266835002285 inhibitor site; inhibition site 266835002286 active site 266835002287 dimer interface [polypeptide binding]; other site 266835002288 catalytic residue [active] 266835002289 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 266835002290 Periplasmic binding domain of two-component sensor kinase signaling systems; Region: PBP1_sensor_kinase_like; cd06308 266835002291 putative ligand binding site [chemical binding]; other site 266835002292 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 266835002293 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 266835002294 TM-ABC transporter signature motif; other site 266835002295 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 266835002296 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 266835002297 active site 266835002298 motif I; other site 266835002299 motif II; other site 266835002300 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 266835002301 Gluconobacter oxydans L-sorbosone dehydrogenase-like; Region: ALDH_SNDH; cd07118 266835002302 NAD(P) binding site [chemical binding]; other site 266835002303 catalytic residues [active] 266835002304 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 266835002305 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266835002306 Walker A/P-loop; other site 266835002307 ATP binding site [chemical binding]; other site 266835002308 Q-loop/lid; other site 266835002309 ABC transporter signature motif; other site 266835002310 Walker B; other site 266835002311 D-loop; other site 266835002312 H-loop/switch region; other site 266835002313 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 266835002314 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12745 266835002315 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR), subgroup 1, classical (c) SDR; Region: BKR_1_SDR_c; cd05337 266835002316 putative NAD(P) binding site [chemical binding]; other site 266835002317 active site 266835002318 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 266835002319 CoA-transferase family III; Region: CoA_transf_3; pfam02515 266835002320 Transcriptional regulators [Transcription]; Region: PurR; COG1609 266835002321 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 266835002322 DNA binding site [nucleotide binding] 266835002323 domain linker motif; other site 266835002324 This group includes the ligand-binding domain of putative DNA transcription repressors which are highly similar to that of the repressor specific for gluconate (GntR), a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR_like_1; cd06273 266835002325 putative ligand binding site [chemical binding]; other site 266835002326 putative dimerization interface [polypeptide binding]; other site 266835002327 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 266835002328 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 266835002329 ligand binding site [chemical binding]; other site 266835002330 NAD binding site [chemical binding]; other site 266835002331 dimerization interface [polypeptide binding]; other site 266835002332 catalytic site [active] 266835002333 cyclase homology domain; Region: CHD; cd07302 266835002334 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 266835002335 nucleotidyl binding site; other site 266835002336 metal binding site [ion binding]; metal-binding site 266835002337 dimer interface [polypeptide binding]; other site 266835002338 Predicted integral membrane protein [Function unknown]; Region: COG5616 266835002339 TPR repeat; Region: TPR_11; pfam13414 266835002340 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266835002341 TPR motif; other site 266835002342 binding surface 266835002343 TPR repeat; Region: TPR_11; pfam13414 266835002344 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266835002345 TPR motif; other site 266835002346 binding surface 266835002347 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 266835002348 cyclase homology domain; Region: CHD; cd07302 266835002349 nucleotidyl binding site; other site 266835002350 metal binding site [ion binding]; metal-binding site 266835002351 dimer interface [polypeptide binding]; other site 266835002352 Predicted integral membrane protein [Function unknown]; Region: COG5616 266835002353 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266835002354 TPR motif; other site 266835002355 binding surface 266835002356 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266835002357 TPR motif; other site 266835002358 binding surface 266835002359 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 266835002360 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 266835002361 TPR motif; other site 266835002362 binding surface 266835002363 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 266835002364 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 266835002365 Predicted transcriptional regulator [Transcription]; Region: COG4957 266835002366 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 266835002367 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 266835002368 HlyD family secretion protein; Region: HlyD_3; pfam13437 266835002369 ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618 266835002370 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 266835002371 ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246 266835002372 Walker A/P-loop; other site 266835002373 ATP binding site [chemical binding]; other site 266835002374 Q-loop/lid; other site 266835002375 ABC transporter signature motif; other site 266835002376 Walker B; other site 266835002377 D-loop; other site 266835002378 H-loop/switch region; other site 266835002379 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 266835002380 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 266835002381 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 266835002382 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 266835002383 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 266835002384 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 266835002385 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 266835002386 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 266835002387 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 266835002388 DNA repair proteins [DNA replication, recombination, and repair]; Region: RadC; COG2003 266835002389 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 266835002390 MPN+ (JAMM) motif; other site 266835002391 Zinc-binding site [ion binding]; other site 266835002392 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 266835002393 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 266835002394 3-hydroxyacyl-CoA dehydrogenase; Validated; Region: PRK06129 266835002395 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 266835002396 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 266835002397 short chain dehydrogenase; Provisional; Region: PRK12829 266835002398 classical (c) SDRs; Region: SDR_c; cd05233 266835002399 NAD(P) binding site [chemical binding]; other site 266835002400 active site 266835002401 Transcriptional regulators [Transcription]; Region: GntR; COG1802 266835002402 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266835002403 DNA-binding site [nucleotide binding]; DNA binding site 266835002404 FCD domain; Region: FCD; pfam07729 266835002405 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 266835002406 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 266835002407 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 266835002408 cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891 266835002409 Heme-copper oxidase subunit III subfamily. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane; Region: Heme_Cu_Oxidase_III_2; cd02865 266835002410 Subunit I/III interface [polypeptide binding]; other site 266835002411 Heme-copper oxidase subunit III subfamily. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane; Region: Heme_Cu_Oxidase_III_1; cd02864 266835002412 Subunit I/III interface [polypeptide binding]; other site 266835002413 Predicted small integral membrane protein [Function unknown]; Region: COG5605 266835002414 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332 266835002415 putative deacylase active site [active] 266835002416 Predicted integral membrane protein [Function unknown]; Region: COG5473 266835002417 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 266835002418 UbiA prenyltransferase family; Region: UbiA; pfam01040 266835002419 Cytochrome c2 [Energy production and conversion]; Region: COG3474 266835002420 putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603 266835002421 trigger factor; Provisional; Region: tig; PRK01490 266835002422 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 266835002423 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 266835002424 Methyltransferase domain; Region: Methyltransf_24; pfam13578 266835002425 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 266835002426 homotrimer interaction site [polypeptide binding]; other site 266835002427 putative active site [active] 266835002428 Predicted membrane protein [Function unknown]; Region: COG4872 266835002429 Uncharacterized conserved small protein [Function unknown]; Region: COG5457 266835002430 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 266835002431 Glucose inhibited division protein A; Region: GIDA; pfam01134 266835002432 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 266835002433 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 266835002434 Phytoene/squalene synthetase [Lipid metabolism]; Region: ERG9; COG1562 266835002435 substrate binding pocket [chemical binding]; other site 266835002436 substrate-Mg2+ binding site; other site 266835002437 aspartate-rich region 1; other site 266835002438 aspartate-rich region 2; other site 266835002439 Mth938-like domain. The members of this family include: Mth938, 2P1, Xcr35, Rpa2829, and several uncharacterized sequences. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a...; Region: Mth938-like; cd00248 266835002440 bifunctional preprotein translocase subunit SecD/SecF; Provisional; Region: PRK14726 266835002441 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 266835002442 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 266835002443 Protein export membrane protein; Region: SecD_SecF; pfam02355 266835002444 Preprotein translocase subunit YajC [Intracellular trafficking and secretion]; Region: YajC; COG1862 266835002445 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 266835002446 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266835002447 Walker A motif; other site 266835002448 ATP binding site [chemical binding]; other site 266835002449 Walker B motif; other site 266835002450 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 266835002451 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266835002452 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 266835002453 atypical (a) SDRs, subgroup 3; Region: SDR_a3; cd05229 266835002454 putative NAD(P) binding site [chemical binding]; other site 266835002455 putative active site [active] 266835002456 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 266835002457 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 266835002458 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 266835002459 Peptidase family M23; Region: Peptidase_M23; pfam01551 266835002460 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 266835002461 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266835002462 S-adenosylmethionine binding site [chemical binding]; other site 266835002463 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 266835002464 seryl-tRNA synthetase; Provisional; Region: PRK05431 266835002465 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 266835002466 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 266835002467 dimer interface [polypeptide binding]; other site 266835002468 active site 266835002469 motif 1; other site 266835002470 motif 2; other site 266835002471 motif 3; other site 266835002472 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 266835002473 twin arginine translocase protein A; Provisional; Region: tatA; PRK00720 266835002474 Chromosome segregation and condensation protein B [DNA replication, recombination and repair]; Region: scpB; COG1386 266835002475 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 266835002476 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 266835002477 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 266835002478 Sporulation related domain; Region: SPOR; pfam05036 266835002479 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 266835002480 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 266835002481 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 266835002482 active site 266835002483 HIGH motif; other site 266835002484 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 266835002485 KMSK motif region; other site 266835002486 tRNA binding surface [nucleotide binding]; other site 266835002487 DALR anticodon binding domain; Region: DALR_1; smart00836 266835002488 anticodon binding site; other site 266835002489 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 266835002490 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 266835002491 Zn2+ binding site [ion binding]; other site 266835002492 Mg2+ binding site [ion binding]; other site 266835002493 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 266835002494 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 266835002495 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 266835002496 active site 266835002497 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 266835002498 putative catalytic site [active] 266835002499 putative phosphate binding site [ion binding]; other site 266835002500 active site 266835002501 metal binding site A [ion binding]; metal-binding site 266835002502 DNA binding site [nucleotide binding] 266835002503 putative AP binding site [nucleotide binding]; other site 266835002504 putative metal binding site B [ion binding]; other site 266835002505 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 266835002506 Sel1-like repeats; Region: SEL1; smart00671 266835002507 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 266835002508 Long-chain fatty acid transport protein [Lipid metabolism]; Region: FadL; COG2067 266835002509 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 266835002510 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 266835002511 HIGH motif; other site 266835002512 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 266835002513 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 266835002514 active site 266835002515 KMSKS motif; other site 266835002516 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 266835002517 tRNA binding surface [nucleotide binding]; other site 266835002518 anticodon binding site; other site 266835002519 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 266835002520 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 266835002521 dimer interface [polypeptide binding]; other site 266835002522 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266835002523 ligand binding site [chemical binding]; other site 266835002524 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3827 266835002525 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 266835002526 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 266835002527 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266835002528 S-adenosylmethionine binding site [chemical binding]; other site 266835002529 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 266835002530 Uncharacterized conserved protein [Function unknown]; Region: COG2128 266835002531 alkylhydroperoxidase AhpD family core domain; Region: ahpD_dom; TIGR00778 266835002532 Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142 266835002533 Predicted acetyltransferase, GNAT superfamily [General function prediction only]; Region: COG3818 266835002534 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_6; cd07824 266835002535 putative hydrophobic ligand binding site [chemical binding]; other site 266835002536 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 266835002537 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 266835002538 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 266835002539 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 266835002540 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 266835002541 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 266835002542 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 266835002543 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 266835002544 catalytic loop [active] 266835002545 iron binding site [ion binding]; other site 266835002546 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 266835002547 Uncharacterized conserved protein [Function unknown]; Region: COG3287 266835002548 FIST N domain; Region: FIST; pfam08495 266835002549 FIST C domain; Region: FIST_C; pfam10442 266835002550 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 266835002551 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266835002552 dimer interface [polypeptide binding]; other site 266835002553 phosphorylation site [posttranslational modification] 266835002554 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266835002555 ATP binding site [chemical binding]; other site 266835002556 Mg2+ binding site [ion binding]; other site 266835002557 G-X-G motif; other site 266835002558 Response regulator receiver domain; Region: Response_reg; pfam00072 266835002559 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 266835002560 active site 266835002561 phosphorylation site [posttranslational modification] 266835002562 intermolecular recognition site; other site 266835002563 dimerization interface [polypeptide binding]; other site 266835002564 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 266835002565 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266835002566 active site 266835002567 phosphorylation site [posttranslational modification] 266835002568 intermolecular recognition site; other site 266835002569 dimerization interface [polypeptide binding]; other site 266835002570 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266835002571 DNA binding residues [nucleotide binding] 266835002572 dimerization interface [polypeptide binding]; other site 266835002573 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 266835002574 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 266835002575 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042 266835002576 maleylacetoacetate isomerase; Region: maiA; TIGR01262 266835002577 C-terminal domain interface [polypeptide binding]; other site 266835002578 GSH binding site (G-site) [chemical binding]; other site 266835002579 putative dimer interface [polypeptide binding]; other site 266835002580 C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191 266835002581 dimer interface [polypeptide binding]; other site 266835002582 N-terminal domain interface [polypeptide binding]; other site 266835002583 maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site 266835002584 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 266835002585 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH6; cd08260 266835002586 putative NAD(P) binding site [chemical binding]; other site 266835002587 catalytic Zn binding site [ion binding]; other site 266835002588 structural Zn binding site [ion binding]; other site 266835002589 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 266835002590 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 266835002591 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266835002592 DNA-binding site [nucleotide binding]; DNA binding site 266835002593 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 266835002594 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266835002595 homodimer interface [polypeptide binding]; other site 266835002596 catalytic residue [active] 266835002597 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266835002598 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_1; cd08460 266835002599 putative substrate binding pocket [chemical binding]; other site 266835002600 putative dimerization interface [polypeptide binding]; other site 266835002601 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266835002602 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 266835002603 putative active site [active] 266835002604 putative catalytic site [active] 266835002605 Uncharacterized conserved protein [Function unknown]; Region: COG5490 266835002606 Predicted membrane protein [Function unknown]; Region: COG2733 266835002607 iron-responsive transcriptional regulator; Reviewed; Region: rirA; PRK11920 266835002608 Rrf2 family protein; Region: rrf2_super; TIGR00738 266835002609 ABC-type hemin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG4559 266835002610 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 266835002611 Walker A/P-loop; other site 266835002612 ATP binding site [chemical binding]; other site 266835002613 Q-loop/lid; other site 266835002614 ABC transporter signature motif; other site 266835002615 Walker B; other site 266835002616 D-loop; other site 266835002617 H-loop/switch region; other site 266835002618 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 266835002619 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 266835002620 ABC-ATPase subunit interface; other site 266835002621 dimer interface [polypeptide binding]; other site 266835002622 putative PBP binding regions; other site 266835002623 ABC-type hemin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ChuT; COG4558 266835002624 Hemin binding protein HutB. These proteins have been shown to function as initial receptors in ABC transport of hemin and hemoproteins in many eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a...; Region: HutB; cd01149 266835002625 putative hemin binding site; other site 266835002626 Putative heme degradation protein [Inorganic ion transport and metabolism]; Region: HemS; COG3720 266835002627 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 266835002628 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 266835002629 Hemin uptake protein [Inorganic ion transport and metabolism]; Region: HemP; COG4256 266835002630 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 266835002631 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 266835002632 N-terminal plug; other site 266835002633 ligand-binding site [chemical binding]; other site 266835002634 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 266835002635 TonB family C-terminal domain; Region: tonB_Cterm; TIGR01352 266835002636 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 266835002637 bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11905 266835002638 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 266835002639 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 266835002640 Glutamate binding site [chemical binding]; other site 266835002641 NAD binding site [chemical binding]; other site 266835002642 catalytic residues [active] 266835002643 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 266835002644 NAD(P) binding site [chemical binding]; other site 266835002645 catalytic residues [active] 266835002646 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 266835002647 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266835002648 putative DNA binding site [nucleotide binding]; other site 266835002649 putative Zn2+ binding site [ion binding]; other site 266835002650 AsnC family; Region: AsnC_trans_reg; pfam01037 266835002651 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 266835002652 cytochrome c-550; Provisional; Region: psbV; cl17239 266835002653 YtkA-like; Region: YtkA; pfam13115 266835002654 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 266835002655 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 266835002656 substrate binding site [chemical binding]; other site 266835002657 ATP binding site [chemical binding]; other site 266835002658 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 266835002659 active site 266835002660 catalytic residues [active] 266835002661 succinic semialdehyde dehydrogenase; Region: PLN02278 266835002662 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 266835002663 tetramerization interface [polypeptide binding]; other site 266835002664 NAD(P) binding site [chemical binding]; other site 266835002665 catalytic residues [active] 266835002666 Predicted permeases [General function prediction only]; Region: COG0679 266835002667 Uncharacterized protein containing caspase domain [General function prediction only]; Region: COG4249 266835002668 Caspase domain; Region: Peptidase_C14; pfam00656 266835002669 Tetratricopeptide repeat; Region: TPR_12; pfam13424 266835002670 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 266835002671 catalytic core [active] 266835002672 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 266835002673 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 266835002674 acyl carrier protein; Provisional; Region: PRK06508 266835002675 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06519 266835002676 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 266835002677 active site 266835002678 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06501 266835002679 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 266835002680 dimer interface [polypeptide binding]; other site 266835002681 active site 266835002682 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 266835002683 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH_like1; cd08266 266835002684 putative NAD(P) binding site [chemical binding]; other site 266835002685 structural Zn binding site [ion binding]; other site 266835002686 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 266835002687 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 266835002688 putative acyl-acceptor binding pocket; other site 266835002689 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266835002690 S-adenosylmethionine binding site [chemical binding]; other site 266835002691 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 266835002692 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 266835002693 Predicted ATP-grasp enzyme [General function prediction only]; Region: COG3919 266835002694 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 266835002695 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 266835002696 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 266835002697 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13013 266835002698 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like6; cd08011 266835002699 metal binding site [ion binding]; metal-binding site 266835002700 putative dimer interface [polypeptide binding]; other site 266835002701 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 266835002702 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494 266835002703 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 266835002704 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835002705 dimer interface [polypeptide binding]; other site 266835002706 conserved gate region; other site 266835002707 putative PBP binding loops; other site 266835002708 ABC-ATPase subunit interface; other site 266835002709 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 266835002710 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835002711 dimer interface [polypeptide binding]; other site 266835002712 conserved gate region; other site 266835002713 putative PBP binding loops; other site 266835002714 ABC-ATPase subunit interface; other site 266835002715 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 266835002716 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266835002717 Walker A/P-loop; other site 266835002718 ATP binding site [chemical binding]; other site 266835002719 Q-loop/lid; other site 266835002720 ABC transporter signature motif; other site 266835002721 Walker B; other site 266835002722 D-loop; other site 266835002723 H-loop/switch region; other site 266835002724 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266835002725 Walker A/P-loop; other site 266835002726 ATP binding site [chemical binding]; other site 266835002727 Q-loop/lid; other site 266835002728 ABC transporter signature motif; other site 266835002729 Walker B; other site 266835002730 D-loop; other site 266835002731 H-loop/switch region; other site 266835002732 tellurium resistance terB-like protein; Region: terB_like; cd07177 266835002733 metal binding site [ion binding]; metal-binding site 266835002734 hypothetical protein; Provisional; Region: PRK10621 266835002735 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 266835002736 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 266835002737 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266835002738 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_14; cd08355 266835002739 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266835002740 cobyric acid synthase; Provisional; Region: PRK00784 266835002741 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 266835002742 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 266835002743 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 266835002744 catalytic triad [active] 266835002745 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 266835002746 Isobutyryl-CoA dehydrogenase; Region: IBD; cd01162 266835002747 substrate binding pocket [chemical binding]; other site 266835002748 FAD binding site [chemical binding]; other site 266835002749 catalytic base [active] 266835002750 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 266835002751 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 266835002752 Cytochrome oxidase complex assembly protein 1; Region: Coa1; pfam08695 266835002753 putative aminotransferase; Validated; Region: PRK07480 266835002754 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 266835002755 inhibitor-cofactor binding pocket; inhibition site 266835002756 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266835002757 catalytic residue [active] 266835002758 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 266835002759 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 266835002760 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266835002761 Major Facilitator Superfamily; Region: MFS_1; pfam07690 266835002762 putative substrate translocation pore; other site 266835002763 Trimethylamine methyltransferase (MTTB); Region: MTTB; pfam06253 266835002764 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 266835002765 hydroxyglutarate oxidase; Provisional; Region: PRK11728 266835002766 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 266835002767 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 266835002768 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 266835002769 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 266835002770 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 266835002771 active site 266835002772 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 266835002773 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 266835002774 Fatty acid desaturase protein family subgroup, a delta-12 acyl-lipid desaturase-like, DesA-like, yet uncharacterized subgroup of membrane fatty acid desaturase proteins found in alpha-, beta-, and gamma-proteobacteria. Sequences of this domain family...; Region: DesA_FADS-like; cd03509 266835002775 putative di-iron ligands [ion binding]; other site 266835002776 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 266835002777 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266835002778 non-specific DNA binding site [nucleotide binding]; other site 266835002779 salt bridge; other site 266835002780 sequence-specific DNA binding site [nucleotide binding]; other site 266835002781 methionine synthase I; Validated; Region: PRK07534 266835002782 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 266835002783 von Willebrand factor; Region: vWF_A; pfam12450 266835002784 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 266835002785 VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subgroup; cd01465 266835002786 metal ion-dependent adhesion site (MIDAS); other site 266835002787 Domain of unknown function (DUF3520); Region: DUF3520; pfam12034 266835002788 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 266835002789 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 266835002790 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 266835002791 DNA binding residues [nucleotide binding] 266835002792 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 266835002793 Methylmalonic aciduria and homocystinuria type C protein and similar proteins; Region: MMACHC-like; cd12959 266835002794 Ferredoxin [Energy production and conversion]; Region: NapF; COG1145 266835002795 Trimethylamine:corrinoid methyltransferase [Coenzyme metabolism]; Region: COG5598 266835002796 Predicted cobalamin binding protein [General function prediction only]; Region: COG5012 266835002797 B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or...; Region: corrinoid_protein_B12-BD; cd02070 266835002798 B12 binding site [chemical binding]; other site 266835002799 cobalt ligand [ion binding]; other site 266835002800 Protein of unknown function (DUF1638); Region: DUF1638; pfam07796 266835002801 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 266835002802 extended (e) SDRs; Region: SDR_e; cd08946 266835002803 NAD(P) binding site [chemical binding]; other site 266835002804 active site 266835002805 Formyl transferase catalytic core domain found in a group of proteins with unknown functions; Region: FMT_core_like_3; cd08653 266835002806 putative active site [active] 266835002807 putative cosubstrate binding site; other site 266835002808 putative substrate binding site [chemical binding]; other site 266835002809 catalytic site [active] 266835002810 Virulence factor; Region: Virulence_fact; pfam13769 266835002811 Methylene-tetrahydrofolate reductase C terminal; Region: MTHFR_C; pfam12225 266835002812 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 266835002813 FAD binding site [chemical binding]; other site 266835002814 Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410 266835002815 methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase; Validated; Region: PRK07535 266835002816 substrate binding pocket [chemical binding]; other site 266835002817 dimer interface [polypeptide binding]; other site 266835002818 inhibitor binding site; inhibition site 266835002819 Domain of unknown function (DUF3483); Region: DUF3483; pfam11982 266835002820 Uncharacterized metal-binding protein [General function prediction only]; Region: COG3894 266835002821 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 266835002822 catalytic loop [active] 266835002823 iron binding site [ion binding]; other site 266835002824 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 266835002825 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 266835002826 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266835002827 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266835002828 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266835002829 dimerization interface [polypeptide binding]; other site 266835002830 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 266835002831 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 266835002832 conserved cys residue [active] 266835002833 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266835002834 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266835002835 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 266835002836 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 266835002837 Walker A/P-loop; other site 266835002838 ATP binding site [chemical binding]; other site 266835002839 Q-loop/lid; other site 266835002840 ABC transporter signature motif; other site 266835002841 Walker B; other site 266835002842 D-loop; other site 266835002843 H-loop/switch region; other site 266835002844 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 266835002845 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835002846 dimer interface [polypeptide binding]; other site 266835002847 conserved gate region; other site 266835002848 putative PBP binding loops; other site 266835002849 ABC-ATPase subunit interface; other site 266835002850 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 266835002851 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 266835002852 substrate binding pocket [chemical binding]; other site 266835002853 membrane-bound complex binding site; other site 266835002854 hinge residues; other site 266835002855 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 266835002856 metal ion-dependent adhesion site (MIDAS); other site 266835002857 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 266835002858 hydroxyglutarate oxidase; Provisional; Region: PRK11728 266835002859 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 266835002860 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 266835002861 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 266835002862 Methyltransferase FkbM domain; Region: Methyltransf_21; cl17387 266835002863 Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992 266835002864 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 266835002865 inhibitor-cofactor binding pocket; inhibition site 266835002866 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266835002867 catalytic residue [active] 266835002868 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 266835002869 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835002870 NAD(P) binding site [chemical binding]; other site 266835002871 active site 266835002872 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971 266835002873 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 266835002874 FAD binding domain; Region: FAD_binding_4; pfam01565 266835002875 hypothetical protein; Validated; Region: PRK08238 266835002876 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 266835002877 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266835002878 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 266835002879 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266835002880 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 266835002881 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835002882 NAD(P) binding site [chemical binding]; other site 266835002883 active site 266835002884 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264 266835002885 Protein of unknown function (DUF1700); Region: DUF1700; pfam08006 266835002886 Mechanosensitive ion channel; Region: MS_channel; pfam00924 266835002887 sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373 266835002888 hydroxyglutarate oxidase; Provisional; Region: PRK11728 266835002889 Sarcosine oxidase delta subunit [Amino acid transport and metabolism]; Region: SoxD; COG4311 266835002890 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 266835002891 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 266835002892 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 266835002893 nudix motif; other site 266835002894 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 266835002895 Sarcosine oxidase gamma subunit [Amino acid transport and metabolism]; Region: COG4583 266835002896 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266835002897 Major Facilitator Superfamily; Region: MFS_1; pfam07690 266835002898 putative substrate translocation pore; other site 266835002899 Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136 266835002900 putative FMN binding site [chemical binding]; other site 266835002901 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 266835002902 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266835002903 sequence-specific DNA binding site [nucleotide binding]; other site 266835002904 salt bridge; other site 266835002905 Cupin domain; Region: Cupin_2; pfam07883 266835002906 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 266835002907 hydroxyglutarate oxidase; Provisional; Region: PRK11728 266835002908 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 266835002909 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 266835002910 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 266835002911 Homocysteine/selenocysteine methylase (S-methylmethionine-dependent) [Amino acid transport and metabolism]; Region: MHT1; COG2040 266835002912 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 266835002913 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 266835002914 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 266835002915 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266835002916 homodimer interface [polypeptide binding]; other site 266835002917 catalytic residue [active] 266835002918 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 266835002919 hydroxyglutarate oxidase; Provisional; Region: PRK11728 266835002920 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 266835002921 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 266835002922 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 266835002923 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 266835002924 Transposase; Region: DEDD_Tnp_IS110; pfam01548 266835002925 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 266835002926 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 266835002927 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 266835002928 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 266835002929 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 266835002930 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 266835002931 FAD binding domain; Region: FAD_binding_4; pfam01565 266835002932 cytosine deaminase-like protein; Validated; Region: PRK07583 266835002933 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 266835002934 active site 266835002935 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 266835002936 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835002937 dimer interface [polypeptide binding]; other site 266835002938 conserved gate region; other site 266835002939 putative PBP binding loops; other site 266835002940 ABC-ATPase subunit interface; other site 266835002941 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 266835002942 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 266835002943 Walker A/P-loop; other site 266835002944 ATP binding site [chemical binding]; other site 266835002945 Q-loop/lid; other site 266835002946 ABC transporter signature motif; other site 266835002947 Walker B; other site 266835002948 D-loop; other site 266835002949 H-loop/switch region; other site 266835002950 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 266835002951 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 266835002952 homotrimer interaction site [polypeptide binding]; other site 266835002953 putative active site [active] 266835002954 Creatinine amidohydrolase; Region: Creatininase; pfam02633 266835002955 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain [Transcription]; Region: COG3609 266835002956 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 266835002957 Predicted protein tyrosine phosphatase [General function prediction only]; Region: COG5350 266835002958 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 266835002959 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 266835002960 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 266835002961 catalytic residue [active] 266835002962 Cobalamin biosynthesis protein CobD/CbiB [Coenzyme metabolism]; Region: CbiB; COG1270 266835002963 Cob(I)alamin adenosyltransferase N terminal; Region: Co_AT_N; pfam12557 266835002964 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 266835002965 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 266835002966 homodimer interface [polypeptide binding]; other site 266835002967 Walker A motif; other site 266835002968 ATP binding site [chemical binding]; other site 266835002969 hydroxycobalamin binding site [chemical binding]; other site 266835002970 Walker B motif; other site 266835002971 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 266835002972 homotrimer interface [polypeptide binding]; other site 266835002973 Walker A motif; other site 266835002974 GTP binding site [chemical binding]; other site 266835002975 Walker B motif; other site 266835002976 Predicted integral membrane protein [Function unknown]; Region: COG5446 266835002977 cobalt transporter subunit CbtB (proposed); Region: CbtB; TIGR02459 266835002978 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 266835002979 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 266835002980 [2Fe-2S] cluster binding site [ion binding]; other site 266835002981 C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884 266835002982 putative alpha subunit interface [polypeptide binding]; other site 266835002983 putative active site [active] 266835002984 putative substrate binding site [chemical binding]; other site 266835002985 Fe binding site [ion binding]; other site 266835002986 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266835002987 Major Facilitator Superfamily; Region: MFS_1; pfam07690 266835002988 putative substrate translocation pore; other site 266835002989 Predicted membrane protein [Function unknown]; Region: COG3503 266835002990 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 266835002991 Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776 266835002992 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 266835002993 DNA binding residues [nucleotide binding] 266835002994 putative dimer interface [polypeptide binding]; other site 266835002995 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 266835002996 MgtE intracellular N domain; Region: MgtE_N; smart00924 266835002997 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 266835002998 Divalent cation transporter; Region: MgtE; cl00786 266835002999 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 266835003000 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266835003001 active site 266835003002 phosphorylation site [posttranslational modification] 266835003003 intermolecular recognition site; other site 266835003004 dimerization interface [polypeptide binding]; other site 266835003005 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266835003006 DNA binding residues [nucleotide binding] 266835003007 dimerization interface [polypeptide binding]; other site 266835003008 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 266835003009 homodimer interface [polypeptide binding]; other site 266835003010 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266835003011 catalytic residue [active] 266835003012 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 266835003013 malate--CoA ligase subunit beta; Provisional; Region: PRK14046 266835003014 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 266835003015 CoA-ligase; Region: Ligase_CoA; pfam00549 266835003016 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 266835003017 CoA binding domain; Region: CoA_binding; smart00881 266835003018 CoA-ligase; Region: Ligase_CoA; pfam00549 266835003019 Domain of unknown function DUF302; Region: DUF302; pfam03625 266835003020 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 266835003021 TAP-like protein; Region: Abhydrolase_4; pfam08386 266835003022 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 266835003023 Cupin; Region: Cupin_6; pfam12852 266835003024 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 266835003025 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266835003026 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 266835003027 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 266835003028 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266835003029 active site 266835003030 phosphorylation site [posttranslational modification] 266835003031 intermolecular recognition site; other site 266835003032 dimerization interface [polypeptide binding]; other site 266835003033 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266835003034 DNA binding site [nucleotide binding] 266835003035 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 266835003036 HAMP domain; Region: HAMP; pfam00672 266835003037 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266835003038 ATP binding site [chemical binding]; other site 266835003039 Mg2+ binding site [ion binding]; other site 266835003040 G-X-G motif; other site 266835003041 lipoate-protein ligase B; Provisional; Region: PRK14341 266835003042 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 266835003043 hydrophobic ligand binding site; other site 266835003044 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160 266835003045 active site 266835003046 putative substrate binding region [chemical binding]; other site 266835003047 Uncharacterized conserved protein [Function unknown]; Region: COG4274 266835003048 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 266835003049 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 266835003050 Walker A/P-loop; other site 266835003051 ATP binding site [chemical binding]; other site 266835003052 Q-loop/lid; other site 266835003053 ABC transporter signature motif; other site 266835003054 Walker B; other site 266835003055 D-loop; other site 266835003056 H-loop/switch region; other site 266835003057 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 266835003058 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 266835003059 FtsX-like permease family; Region: FtsX; pfam02687 266835003060 prolyl-tRNA synthetase; Provisional; Region: PRK12325 266835003061 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 266835003062 dimer interface [polypeptide binding]; other site 266835003063 motif 1; other site 266835003064 active site 266835003065 motif 2; other site 266835003066 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 266835003067 active site 266835003068 motif 3; other site 266835003069 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 266835003070 anticodon binding site; other site 266835003071 Predicted secreted protein [Function unknown]; Region: COG5454 266835003072 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266835003073 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 266835003074 dimer interface [polypeptide binding]; other site 266835003075 substrate binding site [chemical binding]; other site 266835003076 metal binding site [ion binding]; metal-binding site 266835003077 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 266835003078 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 266835003079 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 266835003080 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 266835003081 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 266835003082 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 266835003083 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 266835003084 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 266835003085 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 266835003086 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 266835003087 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 266835003088 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 266835003089 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 266835003090 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 266835003091 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 266835003092 NADH dehydrogenase subunit 6; Validated; Region: ND6; MTH00021 266835003093 NADH dehydrogenase subunit 6; Provisional; Region: ND6; MTH00213 266835003094 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 266835003095 4Fe-4S binding domain; Region: Fer4; cl02805 266835003096 4Fe-4S binding domain; Region: Fer4; pfam00037 266835003097 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 266835003098 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 266835003099 NADH dehydrogenase subunit G; Validated; Region: PRK09130 266835003100 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 266835003101 catalytic loop [active] 266835003102 iron binding site [ion binding]; other site 266835003103 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 266835003104 MopB_Res_Cmplx1_Nad11: The second domain of the Nad11/75-kDa subunit of the NADH-quinone oxidoreductase/respiratory complex I/NADH dehydrogenase-1(NDH-1) of eukaryotes and the Nqo3/G subunit of alphaproteobacteria NDH-1. The NADH-quinone oxidoreductase...; Region: MopB_Res-Cmplx1_Nad11; cd02773 266835003105 Domain of unknown function (DUF1982); Region: DUF1982; pfam09326 266835003106 Uncharacterized conserved protein [Function unknown]; Region: COG3743 266835003107 NADH dehydrogenase I subunit F; Provisional; Region: PRK13596 266835003108 SLBB domain; Region: SLBB; pfam10531 266835003109 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 266835003110 NADH dehydrogenase subunit E; Provisional; Region: PRK12373 266835003111 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 266835003112 putative dimer interface [polypeptide binding]; other site 266835003113 [2Fe-2S] cluster binding site [ion binding]; other site 266835003114 Uncharacterized conserved protein [Function unknown]; Region: COG3743 266835003115 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 266835003116 NADH dehydrogenase subunit D; Validated; Region: PRK06075 266835003117 NADH dehydrogenase subunit C; Provisional; Region: PRK06074 266835003118 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 266835003119 NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377 266835003120 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 266835003121 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 266835003122 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 266835003123 Predicted metal-binding protein [Function unknown]; Region: COG5469 266835003124 cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475 266835003125 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 266835003126 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 266835003127 cobaltochelatase, CobN subunit; Region: cobalto_cobN; TIGR02257 266835003128 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 266835003129 precorrin-3B synthase; Region: CobG; TIGR02435 266835003130 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 266835003131 SRP19 protein; Region: SRP19; cl00617 266835003132 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 266835003133 Precorrin-8X methylmutase; Region: CbiC; pfam02570 266835003134 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 266835003135 active site 266835003136 SAM binding site [chemical binding]; other site 266835003137 homodimer interface [polypeptide binding]; other site 266835003138 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 266835003139 active site 266835003140 SAM binding site [chemical binding]; other site 266835003141 homodimer interface [polypeptide binding]; other site 266835003142 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 266835003143 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571 266835003144 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 266835003145 active site 266835003146 putative homodimer interface [polypeptide binding]; other site 266835003147 SAM binding site [chemical binding]; other site 266835003148 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 266835003149 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266835003150 S-adenosylmethionine binding site [chemical binding]; other site 266835003151 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 266835003152 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 266835003153 active site 266835003154 SAM binding site [chemical binding]; other site 266835003155 homodimer interface [polypeptide binding]; other site 266835003156 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 266835003157 active site 266835003158 SAM binding site [chemical binding]; other site 266835003159 homodimer interface [polypeptide binding]; other site 266835003160 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 266835003161 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 266835003162 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 266835003163 cobalamin synthase; Reviewed; Region: cobS; PRK00235 266835003164 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 266835003165 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 266835003166 putative dimer interface [polypeptide binding]; other site 266835003167 active site pocket [active] 266835003168 putative cataytic base [active] 266835003169 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 266835003170 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 266835003171 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 266835003172 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 266835003173 HlyD family secretion protein; Region: HlyD_3; pfam13437 266835003174 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 266835003175 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 266835003176 Walker A/P-loop; other site 266835003177 ATP binding site [chemical binding]; other site 266835003178 Q-loop/lid; other site 266835003179 ABC transporter signature motif; other site 266835003180 Walker B; other site 266835003181 D-loop; other site 266835003182 H-loop/switch region; other site 266835003183 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 266835003184 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 266835003185 FtsX-like permease family; Region: FtsX; pfam02687 266835003186 BA14K-like protein; Region: BA14K; pfam07886 266835003187 ketol-acid reductoisomerase; Provisional; Region: PRK05479 266835003188 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 266835003189 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 266835003190 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266835003191 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266835003192 Transcriptional regulators [Transcription]; Region: MarR; COG1846 266835003193 MarR family; Region: MarR_2; pfam12802 266835003194 MarR family; Region: MarR_2; cl17246 266835003195 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 266835003196 iron-sulfur cluster [ion binding]; other site 266835003197 [2Fe-2S] cluster binding site [ion binding]; other site 266835003198 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 266835003199 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 266835003200 C-terminal domain interface [polypeptide binding]; other site 266835003201 GSH binding site (G-site) [chemical binding]; other site 266835003202 dimer interface [polypeptide binding]; other site 266835003203 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 266835003204 N-terminal domain interface [polypeptide binding]; other site 266835003205 dimer interface [polypeptide binding]; other site 266835003206 substrate binding pocket (H-site) [chemical binding]; other site 266835003207 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 266835003208 Predicted transcriptional regulators [Transcription]; Region: COG1733 266835003209 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 266835003210 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 266835003211 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 266835003212 NADP binding site [chemical binding]; other site 266835003213 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835003214 K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158 266835003215 K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158 266835003216 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 266835003217 active site 266835003218 hydrophilic channel; other site 266835003219 dimerization interface [polypeptide binding]; other site 266835003220 catalytic residues [active] 266835003221 active site lid [active] 266835003222 ATP-dependent exoDNAse (exonuclease V), alpha subunit - helicase superfamily I member [DNA replication, recombination, and repair]; Region: RecD; COG0507 266835003223 AAA domain; Region: AAA_30; pfam13604 266835003224 Family description; Region: UvrD_C_2; pfam13538 266835003225 nitrile hydratase accessory protein; Region: nitrile_acc; TIGR03889 266835003226 Nitrile hydratase beta subunit; Region: NHase_beta; pfam02211 266835003227 nitrile hydratase, beta subunit; Region: nitrile_beta; TIGR03888 266835003228 Nitrile hydratase, alpha chain; Region: NHase_alpha; pfam02979 266835003229 NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793 266835003230 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 266835003231 Protein export membrane protein; Region: SecD_SecF; cl14618 266835003232 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 266835003233 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 266835003234 HlyD family secretion protein; Region: HlyD_3; pfam13437 266835003235 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 266835003236 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 266835003237 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 266835003238 putative valine binding site [chemical binding]; other site 266835003239 dimer interface [polypeptide binding]; other site 266835003240 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 266835003241 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK09107 266835003242 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 266835003243 PYR/PP interface [polypeptide binding]; other site 266835003244 dimer interface [polypeptide binding]; other site 266835003245 TPP binding site [chemical binding]; other site 266835003246 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 266835003247 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 266835003248 TPP-binding site [chemical binding]; other site 266835003249 dimer interface [polypeptide binding]; other site 266835003250 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 266835003251 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 266835003252 PcfJ-like protein; Region: PcfJ; pfam14284 266835003253 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 266835003254 Zn2+ binding site [ion binding]; other site 266835003255 Mg2+ binding site [ion binding]; other site 266835003256 gamma-butyrobetaine hydroxylase; Region: carnitine_bodg; TIGR02409 266835003257 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cd00250 266835003258 substrate binding pocket [chemical binding]; other site 266835003259 active site 266835003260 iron coordination sites [ion binding]; other site 266835003261 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 266835003262 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266835003263 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266835003264 dimerization interface [polypeptide binding]; other site 266835003265 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 266835003266 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266835003267 non-specific DNA binding site [nucleotide binding]; other site 266835003268 salt bridge; other site 266835003269 sequence-specific DNA binding site [nucleotide binding]; other site 266835003270 HerA helicase [Replication, recombination, and repair]; Region: COG0433 266835003271 Domain of unknown function DUF87; Region: DUF87; pfam01935 266835003272 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 266835003273 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266835003274 metal binding site [ion binding]; metal-binding site 266835003275 active site 266835003276 I-site; other site 266835003277 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 266835003278 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 266835003279 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 266835003280 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 266835003281 motif II; other site 266835003282 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 266835003283 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 266835003284 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 266835003285 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 266835003286 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 266835003287 protein binding site [polypeptide binding]; other site 266835003288 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 266835003289 protein binding site [polypeptide binding]; other site 266835003290 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3242 266835003291 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 266835003292 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 266835003293 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 266835003294 HflK protein; Region: hflK; TIGR01933 266835003295 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 266835003296 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 266835003297 folate binding site [chemical binding]; other site 266835003298 NADP+ binding site [chemical binding]; other site 266835003299 Domain of unknown function (DUF4424); Region: DUF4424; pfam14415 266835003300 Precorrin-6A synthase, the cobalamin biosynthesis enzyme CobF; Region: Precorrin-6A-synthase; cd11643 266835003301 active site 266835003302 SAM binding site [chemical binding]; other site 266835003303 homodimer interface [polypeptide binding]; other site 266835003304 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 266835003305 ABC-type molybdate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: ModC; COG4148 266835003306 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266835003307 Walker A/P-loop; other site 266835003308 ATP binding site [chemical binding]; other site 266835003309 Q-loop/lid; other site 266835003310 ABC transporter signature motif; other site 266835003311 Walker B; other site 266835003312 D-loop; other site 266835003313 H-loop/switch region; other site 266835003314 TOBE domain; Region: TOBE; pfam03459 266835003315 molybdate ABC transporter permease protein; Reviewed; Region: modB; PRK09421 266835003316 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 266835003317 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 266835003318 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 266835003319 thymidylate synthase; Reviewed; Region: thyA; PRK01827 266835003320 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 266835003321 dimerization interface [polypeptide binding]; other site 266835003322 active site 266835003323 Protein of unknown function (DUF2853); Region: DUF2853; pfam11015 266835003324 Predicted ATPase [General function prediction only]; Region: COG3911 266835003325 AAA domain; Region: AAA_28; pfam13521 266835003326 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 266835003327 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266835003328 putative substrate translocation pore; other site 266835003329 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266835003330 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266835003331 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 266835003332 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3814 266835003333 Domain of unknown function (DUF4169); Region: DUF4169; pfam13770 266835003334 Uncharacterized protein related to arylsulfate sulfotransferase involved in siderophore biosynthesis [General function prediction only]; Region: COG4321 266835003335 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 266835003336 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 266835003337 Cl- selectivity filter; other site 266835003338 Cl- binding residues [ion binding]; other site 266835003339 pore gating glutamate residue; other site 266835003340 dimer interface [polypeptide binding]; other site 266835003341 FOG: CBS domain [General function prediction only]; Region: COG0517 266835003342 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc; cd04612 266835003343 Transcriptional regulators [Transcription]; Region: MarR; COG1846 266835003344 MarR family; Region: MarR_2; pfam12802 266835003345 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 266835003346 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 266835003347 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 266835003348 DNA binding residues [nucleotide binding] 266835003349 SnoaL-like domain; Region: SnoaL_2; pfam12680 266835003350 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 266835003351 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 266835003352 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 266835003353 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 266835003354 FAD binding domain; Region: FAD_binding_4; pfam01565 266835003355 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 266835003356 active site 266835003357 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 266835003358 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266835003359 putative DNA binding site [nucleotide binding]; other site 266835003360 putative Zn2+ binding site [ion binding]; other site 266835003361 AsnC family; Region: AsnC_trans_reg; pfam01037 266835003362 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 266835003363 EamA-like transporter family; Region: EamA; pfam00892 266835003364 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 266835003365 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 266835003366 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 266835003367 Trp docking motif [polypeptide binding]; other site 266835003368 putative active site [active] 266835003369 Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; pfam09832 266835003370 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 266835003371 Part of AAA domain; Region: AAA_19; pfam13245 266835003372 Family description; Region: UvrD_C_2; pfam13538 266835003373 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 266835003374 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 266835003375 TM-ABC transporter signature motif; other site 266835003376 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 266835003377 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266835003378 Walker A/P-loop; other site 266835003379 ATP binding site [chemical binding]; other site 266835003380 Q-loop/lid; other site 266835003381 ABC transporter signature motif; other site 266835003382 Walker B; other site 266835003383 D-loop; other site 266835003384 H-loop/switch region; other site 266835003385 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312 266835003386 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 266835003387 putative ligand binding site [chemical binding]; other site 266835003388 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 266835003389 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 266835003390 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 266835003391 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 266835003392 Transcriptional regulators [Transcription]; Region: PurR; COG1609 266835003393 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 266835003394 DNA binding site [nucleotide binding] 266835003395 domain linker motif; other site 266835003396 Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271 266835003397 ligand binding site [chemical binding]; other site 266835003398 Uncharacterized conserved protein [Function unknown]; Region: COG3461 266835003399 Protein of unknown function (DUF4239); Region: DUF4239; pfam14023 266835003400 Trimethylamine methyltransferase (MTTB); Region: MTTB; pfam06253 266835003401 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 266835003402 hydroxyglutarate oxidase; Provisional; Region: PRK11728 266835003403 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 266835003404 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 266835003405 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4222 266835003406 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 266835003407 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 266835003408 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 266835003409 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 266835003410 Major Facilitator Superfamily; Region: MFS_1; pfam07690 266835003411 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266835003412 Predicted integral membrane protein [Function unknown]; Region: COG3548 266835003413 hypothetical protein; Provisional; Region: PRK06194 266835003414 classical (c) SDRs; Region: SDR_c; cd05233 266835003415 NAD(P) binding site [chemical binding]; other site 266835003416 active site 266835003417 Low affinity iron permease; Region: Iron_permease; pfam04120 266835003418 phosphonate metabolim protein, transferase hexapeptide repeat family; Region: phn_thr-fam; TIGR03308 266835003419 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 266835003420 trimer interface [polypeptide binding]; other site 266835003421 active site 266835003422 substrate binding site [chemical binding]; other site 266835003423 CoA binding site [chemical binding]; other site 266835003424 Uncharacterized protein conserved in bacteria [Function unknown]; Region: CreA; COG3045 266835003425 CreA protein; Region: CreA; pfam05981 266835003426 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 266835003427 Protein of unknown function (DUF1093); Region: DUF1093; cl02185 266835003428 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 266835003429 Cu(I) binding site [ion binding]; other site 266835003430 Ribosomal protein L11 methylase [Translation, ribosomal structure and biogenesis]; Region: PrmA; COG2264 266835003431 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266835003432 S-adenosylmethionine binding site [chemical binding]; other site 266835003433 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 266835003434 Uncharacterized protein with a C-terminal OMP (outer membrane protein) domain [Function unknown]; Region: COG4625 266835003435 Autotransporter beta-domain; Region: Autotransporter; pfam03797 266835003436 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 266835003437 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 266835003438 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085 266835003439 active site 266835003440 Predicted membrane protein [Function unknown]; Region: COG4541 266835003441 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 266835003442 Uncharacterized conserved protein [Function unknown]; Region: COG5587 266835003443 NAD-dependent DNA ligase (contains BRCT domain type II) [DNA replication, recombination, and repair]; Region: Lig; COG0272 266835003444 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 266835003445 nucleotide binding pocket [chemical binding]; other site 266835003446 K-X-D-G motif; other site 266835003447 catalytic site [active] 266835003448 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 266835003449 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 266835003450 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 266835003451 Dimer interface [polypeptide binding]; other site 266835003452 BRCT sequence motif; other site 266835003453 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 266835003454 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 266835003455 Walker A/P-loop; other site 266835003456 ATP binding site [chemical binding]; other site 266835003457 Q-loop/lid; other site 266835003458 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 266835003459 ABC transporter signature motif; other site 266835003460 Walker B; other site 266835003461 D-loop; other site 266835003462 H-loop/switch region; other site 266835003463 DNA uptake lipoprotein [General function prediction only]; Region: ComL; COG4105 266835003464 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 266835003465 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 266835003466 Cell division GTPase [Cell division and chromosome partitioning]; Region: FtsZ; COG0206 266835003467 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 266835003468 nucleotide binding site [chemical binding]; other site 266835003469 SulA interaction site; other site 266835003470 cell division protein FtsZ, alphaProteobacterial C-terminal extension; Region: FtsZ_alphas_C; TIGR03483 266835003471 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 266835003472 Cell division protein FtsA; Region: FtsA; smart00842 266835003473 Cell division protein FtsA; Region: FtsA; pfam14450 266835003474 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 266835003475 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 266835003476 Cell division protein FtsQ; Region: FtsQ; pfam03799 266835003477 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 266835003478 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 266835003479 ATP-grasp domain; Region: ATP-grasp_4; cl17255 266835003480 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 266835003481 FAD binding domain; Region: FAD_binding_4; pfam01565 266835003482 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 266835003483 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 266835003484 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 266835003485 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 266835003486 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 266835003487 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 266835003488 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 266835003489 active site 266835003490 homodimer interface [polypeptide binding]; other site 266835003491 cell division protein FtsW; Region: ftsW; TIGR02614 266835003492 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01390 266835003493 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 266835003494 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 266835003495 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 266835003496 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 266835003497 Mg++ binding site [ion binding]; other site 266835003498 putative catalytic motif [active] 266835003499 putative substrate binding site [chemical binding]; other site 266835003500 UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate--D-alanyl-D-alanine ligase; Provisional; Region: PRK14093 266835003501 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 266835003502 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 266835003503 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 266835003504 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 266835003505 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 266835003506 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 266835003507 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 266835003508 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 266835003509 Predicted secreted (periplasmic) protein [Function unknown]; Region: COG5462 266835003510 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 266835003511 MraW methylase family; Region: Methyltransf_5; cl17771 266835003512 cystathionine gamma-lyase; Validated; Region: PRK07582 266835003513 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 266835003514 homodimer interface [polypeptide binding]; other site 266835003515 substrate-cofactor binding pocket; other site 266835003516 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266835003517 catalytic residue [active] 266835003518 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 266835003519 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 266835003520 N-acetyl-D-glucosamine binding site [chemical binding]; other site 266835003521 catalytic residue [active] 266835003522 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 266835003523 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 266835003524 amidase catalytic site [active] 266835003525 Zn binding residues [ion binding]; other site 266835003526 substrate binding site [chemical binding]; other site 266835003527 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 266835003528 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 266835003529 DnaJ-domain-containing proteins 1 [Posttranslational modification, protein turnover, chaperones]; Region: DjlA; COG1076 266835003530 putative metal binding site [ion binding]; other site 266835003531 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 266835003532 HSP70 interaction site [polypeptide binding]; other site 266835003533 5-oxoprolinase; Region: PLN02666 266835003534 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 266835003535 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 266835003536 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 266835003537 S-adenosylmethionine:diacylglycerol 3-amino-3-carboxypropyl transferase [Lipid metabolism]; Region: BtaA; COG5379 266835003538 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266835003539 S-adenosylmethionine binding site [chemical binding]; other site 266835003540 Plasmid maintenance system killer protein [General function prediction only]; Region: HigB; COG3549 266835003541 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 266835003542 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266835003543 non-specific DNA binding site [nucleotide binding]; other site 266835003544 salt bridge; other site 266835003545 sequence-specific DNA binding site [nucleotide binding]; other site 266835003546 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 266835003547 Beta-lactamase; Region: Beta-lactamase; pfam00144 266835003548 Lyzozyme M1 (1,4-beta-N-acetylmuramidase) [Cell envelope biogenesis, outer membrane]; Region: Acm; COG3757 266835003549 Uncharacterized bacterial muramidase containing a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis...; Region: GH25_muramidase_1; cd06413 266835003550 active site 266835003551 Transglycosylase SLT domain; Region: SLT_2; pfam13406 266835003552 murein hydrolase B; Provisional; Region: PRK10760; cl17906 266835003553 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 266835003554 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266835003555 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266835003556 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 266835003557 putative effector binding pocket; other site 266835003558 putative dimerization interface [polypeptide binding]; other site 266835003559 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 266835003560 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835003561 NAD(P) binding site [chemical binding]; other site 266835003562 active site 266835003563 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 266835003564 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 266835003565 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 266835003566 catalytic residue [active] 266835003567 EamA-like transporter family; Region: EamA; pfam00892 266835003568 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 266835003569 FAD binding site [chemical binding]; other site 266835003570 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266835003571 putative Zn2+ binding site [ion binding]; other site 266835003572 putative DNA binding site [nucleotide binding]; other site 266835003573 Methyltransferase domain; Region: Methyltransf_31; pfam13847 266835003574 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266835003575 S-adenosylmethionine binding site [chemical binding]; other site 266835003576 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 266835003577 homodimer interaction site [polypeptide binding]; other site 266835003578 cofactor binding site; other site 266835003579 Uncharacterized conserved protein [Function unknown]; Region: COG5586 266835003580 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 266835003581 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 266835003582 homodimer interface [polypeptide binding]; other site 266835003583 substrate-cofactor binding pocket; other site 266835003584 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266835003585 catalytic residue [active] 266835003586 short chain dehydrogenase; Provisional; Region: PRK08263 266835003587 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 266835003588 NADP binding site [chemical binding]; other site 266835003589 active site 266835003590 steroid binding site; other site 266835003591 MOSC domain; Region: MOSC; pfam03473 266835003592 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266835003593 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266835003594 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 266835003595 dimer interface [polypeptide binding]; other site 266835003596 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266835003597 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 266835003598 Uncharacterized conserved protein [Function unknown]; Region: COG3791 266835003599 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 266835003600 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 266835003601 dimer interface [polypeptide binding]; other site 266835003602 active site 266835003603 CoA binding pocket [chemical binding]; other site 266835003604 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 266835003605 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266835003606 S-adenosylmethionine binding site [chemical binding]; other site 266835003607 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 266835003608 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266835003609 Walker A/P-loop; other site 266835003610 ATP binding site [chemical binding]; other site 266835003611 Q-loop/lid; other site 266835003612 ABC transporter signature motif; other site 266835003613 Walker B; other site 266835003614 D-loop; other site 266835003615 H-loop/switch region; other site 266835003616 ABC transporter; Region: ABC_tran_2; pfam12848 266835003617 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 266835003618 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 266835003619 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266835003620 metal binding site [ion binding]; metal-binding site 266835003621 active site 266835003622 I-site; other site 266835003623 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062 266835003624 B1 nucleotide binding pocket [chemical binding]; other site 266835003625 B2 nucleotide binding pocket [chemical binding]; other site 266835003626 CAS motifs; other site 266835003627 active site 266835003628 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 266835003629 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 266835003630 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 266835003631 CoA-transferase family III; Region: CoA_transf_3; pfam02515 266835003632 thiamine pyrophosphate protein; Validated; Region: PRK08199 266835003633 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 266835003634 PYR/PP interface [polypeptide binding]; other site 266835003635 dimer interface [polypeptide binding]; other site 266835003636 TPP binding site [chemical binding]; other site 266835003637 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 266835003638 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 266835003639 TPP-binding site [chemical binding]; other site 266835003640 CHRD domain; Region: CHRD; pfam07452 266835003641 methionine gamma-lyase; Validated; Region: PRK07049 266835003642 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 266835003643 homodimer interface [polypeptide binding]; other site 266835003644 substrate-cofactor binding pocket; other site 266835003645 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266835003646 catalytic residue [active] 266835003647 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266835003648 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 266835003649 putative DNA binding site [nucleotide binding]; other site 266835003650 putative Zn2+ binding site [ion binding]; other site 266835003651 AsnC family; Region: AsnC_trans_reg; pfam01037 266835003652 NMT1/THI5 like; Region: NMT1; pfam09084 266835003653 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 266835003654 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 266835003655 Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528 266835003656 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 266835003657 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835003658 dimer interface [polypeptide binding]; other site 266835003659 conserved gate region; other site 266835003660 putative PBP binding loops; other site 266835003661 ABC-ATPase subunit interface; other site 266835003662 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 266835003663 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 266835003664 Walker A/P-loop; other site 266835003665 ATP binding site [chemical binding]; other site 266835003666 Q-loop/lid; other site 266835003667 ABC transporter signature motif; other site 266835003668 Walker B; other site 266835003669 D-loop; other site 266835003670 H-loop/switch region; other site 266835003671 Predicted mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: COG4101 266835003672 phenylhydantoinase; Validated; Region: PRK08323 266835003673 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 266835003674 tetramer interface [polypeptide binding]; other site 266835003675 active site 266835003676 allantoate amidohydrolase; Reviewed; Region: PRK12893 266835003677 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 266835003678 active site 266835003679 metal binding site [ion binding]; metal-binding site 266835003680 dimer interface [polypeptide binding]; other site 266835003681 beta alanine--pyruvate transaminase; Provisional; Region: PRK09221 266835003682 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 266835003683 inhibitor-cofactor binding pocket; inhibition site 266835003684 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266835003685 catalytic residue [active] 266835003686 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 266835003687 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266835003688 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 266835003689 Helix-turn-helix domain; Region: HTH_31; pfam13560 266835003690 short chain dehydrogenase; Provisional; Region: PRK12828 266835003691 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 266835003692 putative NAD(P) binding site [chemical binding]; other site 266835003693 active site 266835003694 short chain dehydrogenase; Provisional; Region: PRK07041 266835003695 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835003696 NAD(P) binding site [chemical binding]; other site 266835003697 active site 266835003698 Predicted membrane protein [Function unknown]; Region: COG2259 266835003699 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 266835003700 Uncharacterized conserved protein [Function unknown]; Region: COG2128 266835003701 Predicted transcriptional regulator [Transcription]; Region: COG1959 266835003702 Transcriptional regulator; Region: Rrf2; pfam02082 266835003703 dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318 266835003704 Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940 266835003705 homodimer interface [polypeptide binding]; other site 266835003706 active site 266835003707 FMN binding site [chemical binding]; other site 266835003708 substrate binding site [chemical binding]; other site 266835003709 4Fe-4S binding domain; Region: Fer4_6; pfam12837 266835003710 4Fe-4S binding domain; Region: Fer4; pfam00037 266835003711 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266835003712 S-adenosylmethionine binding site [chemical binding]; other site 266835003713 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 266835003714 Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703 266835003715 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 266835003716 putative active site pocket [active] 266835003717 dimerization interface [polypeptide binding]; other site 266835003718 putative catalytic residue [active] 266835003719 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 266835003720 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266835003721 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266835003722 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 266835003723 Predicted membrane protein [Function unknown]; Region: COG2259 266835003724 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 266835003725 hydroxyglutarate oxidase; Provisional; Region: PRK11728 266835003726 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 266835003727 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 266835003728 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 266835003729 Trimethylamine methyltransferase (MTTB); Region: MTTB; pfam06253 266835003730 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 266835003731 N-acetyl-D-glucosamine binding site [chemical binding]; other site 266835003732 catalytic residue [active] 266835003733 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 266835003734 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266835003735 Walker A/P-loop; other site 266835003736 ATP binding site [chemical binding]; other site 266835003737 Q-loop/lid; other site 266835003738 ABC transporter signature motif; other site 266835003739 Walker B; other site 266835003740 D-loop; other site 266835003741 H-loop/switch region; other site 266835003742 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 266835003743 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266835003744 Walker A/P-loop; other site 266835003745 ATP binding site [chemical binding]; other site 266835003746 Q-loop/lid; other site 266835003747 ABC transporter signature motif; other site 266835003748 Walker B; other site 266835003749 D-loop; other site 266835003750 H-loop/switch region; other site 266835003751 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 266835003752 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 266835003753 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835003754 dimer interface [polypeptide binding]; other site 266835003755 conserved gate region; other site 266835003756 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 266835003757 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 266835003758 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835003759 dimer interface [polypeptide binding]; other site 266835003760 conserved gate region; other site 266835003761 putative PBP binding loops; other site 266835003762 ABC-ATPase subunit interface; other site 266835003763 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 266835003764 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 266835003765 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 266835003766 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 266835003767 Family of unknown function (DUF490); Region: DUF490; pfam04357 266835003768 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 266835003769 Surface antigen; Region: Bac_surface_Ag; pfam01103 266835003770 Subfamily of PAN/APPLE-like domains; present in plasma prekallikrein/coagulation factor XI, microneme antigen proteins, and a few prokaryotic proteins. PAN/APPLE domains fulfill diverse biological functions by mediating protein-protein or...; Region: APPLE_Factor_XI_like; cd01100 266835003771 putative binding site; other site 266835003772 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 266835003773 MG2 domain; Region: A2M_N; pfam01835 266835003774 Alpha-2-macroglobulin family; Region: A2M; pfam00207 266835003775 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 266835003776 surface patch; other site 266835003777 thioester region; other site 266835003778 specificity defining residues; other site 266835003779 Membrane carboxypeptidase/penicillin-binding protein PbpC [Cell envelope biogenesis, outer membrane]; Region: PbpC; COG4953 266835003780 Transglycosylase; Region: Transgly; pfam00912 266835003781 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 266835003782 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 266835003783 D-alanyl-D-alanine dipeptidase [Cell envelope biogenesis, outer membrane]; Region: DdpX; COG2173 266835003784 ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613 266835003785 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 266835003786 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 266835003787 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835003788 dimer interface [polypeptide binding]; other site 266835003789 conserved gate region; other site 266835003790 putative PBP binding loops; other site 266835003791 ABC-ATPase subunit interface; other site 266835003792 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835003793 dimer interface [polypeptide binding]; other site 266835003794 conserved gate region; other site 266835003795 putative PBP binding loops; other site 266835003796 ABC-ATPase subunit interface; other site 266835003797 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 266835003798 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 266835003799 Walker A/P-loop; other site 266835003800 ATP binding site [chemical binding]; other site 266835003801 Q-loop/lid; other site 266835003802 ABC transporter signature motif; other site 266835003803 Walker B; other site 266835003804 D-loop; other site 266835003805 H-loop/switch region; other site 266835003806 TOBE-like domain; Region: TOBE_3; pfam12857 266835003807 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 266835003808 oligomeric interface; other site 266835003809 putative active site [active] 266835003810 homodimer interface [polypeptide binding]; other site 266835003811 Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456 266835003812 ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CysP; COG4150 266835003813 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 266835003814 Predicted transcriptional regulator [Transcription]; Region: COG1959 266835003815 Transcriptional regulator; Region: Rrf2; pfam02082 266835003816 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 266835003817 AAA domain; Region: AAA_33; pfam13671 266835003818 ATP-binding site [chemical binding]; other site 266835003819 Gluconate-6-phosphate binding site [chemical binding]; other site 266835003820 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 266835003821 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 266835003822 TM-ABC transporter signature motif; other site 266835003823 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 266835003824 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 266835003825 TM-ABC transporter signature motif; other site 266835003826 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 266835003827 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 266835003828 Walker A/P-loop; other site 266835003829 ATP binding site [chemical binding]; other site 266835003830 Q-loop/lid; other site 266835003831 ABC transporter signature motif; other site 266835003832 Walker B; other site 266835003833 D-loop; other site 266835003834 H-loop/switch region; other site 266835003835 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 266835003836 Periplasmic sugar-binding component of uncharacterized ABC-type transport systems that are members of the pentose/hexose sugar-binding protein family of the type I periplasmic binding protein superfamily; Region: PBP1_ABC_sugar_binding_like_1; cd06300 266835003837 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 266835003838 putative ligand binding site [chemical binding]; other site 266835003839 Transcriptional regulators [Transcription]; Region: PurR; COG1609 266835003840 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 266835003841 DNA binding site [nucleotide binding] 266835003842 domain linker motif; other site 266835003843 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 266835003844 putative ligand binding site [chemical binding]; other site 266835003845 putative dimerization interface [polypeptide binding]; other site 266835003846 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266835003847 Major Facilitator Superfamily; Region: MFS_1; pfam07690 266835003848 putative substrate translocation pore; other site 266835003849 Transcriptional regulators [Transcription]; Region: FadR; COG2186 266835003850 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266835003851 DNA-binding site [nucleotide binding]; DNA binding site 266835003852 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 266835003853 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 266835003854 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835003855 NAD(P) binding site [chemical binding]; other site 266835003856 active site 266835003857 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 266835003858 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 266835003859 Transcriptional regulators [Transcription]; Region: FadR; COG2186 266835003860 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266835003861 DNA-binding site [nucleotide binding]; DNA binding site 266835003862 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 266835003863 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 266835003864 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 266835003865 ligand binding site [chemical binding]; other site 266835003866 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 266835003867 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266835003868 Walker A/P-loop; other site 266835003869 ATP binding site [chemical binding]; other site 266835003870 Q-loop/lid; other site 266835003871 ABC transporter signature motif; other site 266835003872 Walker B; other site 266835003873 D-loop; other site 266835003874 H-loop/switch region; other site 266835003875 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 266835003876 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 266835003877 TM-ABC transporter signature motif; other site 266835003878 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266835003879 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 266835003880 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 266835003881 putative hydrophobic ligand binding site [chemical binding]; other site 266835003882 protein interface [polypeptide binding]; other site 266835003883 gate; other site 266835003884 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 266835003885 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 266835003886 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 266835003887 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 266835003888 catalytic loop [active] 266835003889 iron binding site [ion binding]; other site 266835003890 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 266835003891 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 266835003892 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 266835003893 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 266835003894 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 266835003895 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 266835003896 MoxR-like ATPases [General function prediction only]; Region: COG0714 266835003897 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266835003898 Walker A motif; other site 266835003899 ATP binding site [chemical binding]; other site 266835003900 Walker B motif; other site 266835003901 VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762 266835003902 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 266835003903 metal ion-dependent adhesion site (MIDAS); other site 266835003904 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 266835003905 Amidohydrolase; Region: Amidohydro_2; pfam04909 266835003906 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 266835003907 Transposase; Region: DEDD_Tnp_IS110; pfam01548 266835003908 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 266835003909 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 266835003910 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 266835003911 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 266835003912 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835003913 dimer interface [polypeptide binding]; other site 266835003914 conserved gate region; other site 266835003915 putative PBP binding loops; other site 266835003916 ABC-ATPase subunit interface; other site 266835003917 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835003918 dimer interface [polypeptide binding]; other site 266835003919 conserved gate region; other site 266835003920 putative PBP binding loops; other site 266835003921 ABC-ATPase subunit interface; other site 266835003922 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 266835003923 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266835003924 Walker A/P-loop; other site 266835003925 ATP binding site [chemical binding]; other site 266835003926 Q-loop/lid; other site 266835003927 ABC transporter signature motif; other site 266835003928 Walker B; other site 266835003929 D-loop; other site 266835003930 H-loop/switch region; other site 266835003931 TOBE domain; Region: TOBE_2; pfam08402 266835003932 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 266835003933 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 266835003934 active site 266835003935 metal binding site [ion binding]; metal-binding site 266835003936 Uncharacterized conserved protein [Function unknown]; Region: COG2128 266835003937 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 266835003938 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 266835003939 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 266835003940 Walker A/P-loop; other site 266835003941 ATP binding site [chemical binding]; other site 266835003942 Q-loop/lid; other site 266835003943 ABC transporter signature motif; other site 266835003944 Walker B; other site 266835003945 D-loop; other site 266835003946 H-loop/switch region; other site 266835003947 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 266835003948 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 266835003949 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 266835003950 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 266835003951 TM-ABC transporter signature motif; other site 266835003952 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 266835003953 Strictosidine synthase; Region: Str_synth; pfam03088 266835003954 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 266835003955 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 266835003956 ligand binding site [chemical binding]; other site 266835003957 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 266835003958 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 266835003959 TM-ABC transporter signature motif; other site 266835003960 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266835003961 putative transporter; Provisional; Region: PRK10504 266835003962 putative substrate translocation pore; other site 266835003963 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 266835003964 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 266835003965 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 266835003966 active sites [active] 266835003967 tetramer interface [polypeptide binding]; other site 266835003968 Ketopantoate hydroxymethyltransferase [Coenzyme metabolism]; Region: PanB; COG0413 266835003969 oligomerization interface [polypeptide binding]; other site 266835003970 active site 266835003971 metal binding site [ion binding]; metal-binding site 266835003972 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 266835003973 [2Fe-2S] cluster binding site [ion binding]; other site 266835003974 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 266835003975 This CD includes the putative hydrocarbon oxygenase, MocD, a bacterial rhizopine (3-O-methyl-scyllo-inosamine, 3-O-MSI) oxygenase, and other related proteins. It has been proposed that MocD, MocE (Rieske-like ferredoxin), and MocF (ferredoxin reductase)...; Region: Rhizopine-oxygenase-like; cd03511 266835003976 putative di-iron ligands [ion binding]; other site 266835003977 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 266835003978 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 266835003979 DNA interaction; other site 266835003980 Metal-binding active site; metal-binding site 266835003981 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 266835003982 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 266835003983 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 266835003984 Putative Aconitase X swivel domain. It is predicted by comparative genomic analysis. The proteins are mainly found in archaea and proteobacteria. They are distantly related to Aconitase family of proteins by sequence similarity and seconary structure...; Region: AcnX_swivel; cd01356 266835003985 substrate binding site [chemical binding]; other site 266835003986 Protein of unknown function (DUF521); Region: DUF521; pfam04412 266835003987 Putative Aconitase X catalytic domain; Region: AcnX; cd01355 266835003988 substrate binding site [chemical binding]; other site 266835003989 ligand binding site [chemical binding]; other site 266835003990 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 266835003991 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266835003992 Walker A/P-loop; other site 266835003993 ATP binding site [chemical binding]; other site 266835003994 Q-loop/lid; other site 266835003995 ABC transporter signature motif; other site 266835003996 Walker B; other site 266835003997 D-loop; other site 266835003998 H-loop/switch region; other site 266835003999 TOBE domain; Region: TOBE_2; pfam08402 266835004000 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 266835004001 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835004002 dimer interface [polypeptide binding]; other site 266835004003 conserved gate region; other site 266835004004 putative PBP binding loops; other site 266835004005 ABC-ATPase subunit interface; other site 266835004006 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835004007 dimer interface [polypeptide binding]; other site 266835004008 conserved gate region; other site 266835004009 putative PBP binding loops; other site 266835004010 ABC-ATPase subunit interface; other site 266835004011 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 266835004012 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 266835004013 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 266835004014 YegV-like sugar kinase. Found only in bacteria, YegV-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YegV_kinase_like; cd01944 266835004015 substrate binding site [chemical binding]; other site 266835004016 ATP binding site [chemical binding]; other site 266835004017 ADP-ribosylglycohydrolase [Posttranslational modification, protein turnover, chaperones]; Region: DraG; COG1397 266835004018 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 266835004019 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266835004020 DNA-binding site [nucleotide binding]; DNA binding site 266835004021 UTRA domain; Region: UTRA; pfam07702 266835004022 PAS domain; Region: PAS_9; pfam13426 266835004023 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 266835004024 Histidine kinase; Region: HisKA_2; pfam07568 266835004025 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266835004026 ATP binding site [chemical binding]; other site 266835004027 Mg2+ binding site [ion binding]; other site 266835004028 G-X-G motif; other site 266835004029 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 266835004030 NMT1/THI5 like; Region: NMT1; pfam09084 266835004031 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 266835004032 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 266835004033 Walker A/P-loop; other site 266835004034 ATP binding site [chemical binding]; other site 266835004035 Q-loop/lid; other site 266835004036 ABC transporter signature motif; other site 266835004037 Walker B; other site 266835004038 D-loop; other site 266835004039 H-loop/switch region; other site 266835004040 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 266835004041 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835004042 dimer interface [polypeptide binding]; other site 266835004043 conserved gate region; other site 266835004044 putative PBP binding loops; other site 266835004045 ABC-ATPase subunit interface; other site 266835004046 YKOF-related Family; Region: Ykof; pfam07615 266835004047 YKOF-related Family; Region: Ykof; pfam07615 266835004048 methionine sulfoxide reductase A; Provisional; Region: PRK14054 266835004049 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 266835004050 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 266835004051 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 266835004052 Coenzyme A binding pocket [chemical binding]; other site 266835004053 Bacteriophage terminase large (ATPase) subunit and inactivated derivatives [General function prediction only]; Region: COG5565 266835004054 Bacteriophage terminase large (ATPase) subunit and inactivated derivatives [General function prediction only]; Region: COG5565 266835004055 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 266835004056 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266835004057 active site 266835004058 Protein of unknown function (DUF3606); Region: DUF3606; pfam12244 266835004059 Uncharacterized conserved protein [Function unknown]; Region: COG3791 266835004060 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 266835004061 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 266835004062 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 266835004063 active site 266835004064 Uncharacterized conserved protein [Function unknown]; Region: COG2155 266835004065 PAS domain S-box; Region: sensory_box; TIGR00229 266835004066 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266835004067 putative active site [active] 266835004068 heme pocket [chemical binding]; other site 266835004069 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 266835004070 HWE histidine kinase; Region: HWE_HK; pfam07536 266835004071 nickel responsive regulator; Provisional; Region: PRK02967 266835004072 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 266835004073 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 266835004074 active site 266835004075 catalytic tetrad [active] 266835004076 Uncharacterized protein containing caspase domain [General function prediction only]; Region: COG4249 266835004077 Caspase domain; Region: Peptidase_C14; pfam00656 266835004078 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 266835004079 Sel1-like repeats; Region: SEL1; smart00671 266835004080 Sel1-like repeats; Region: SEL1; smart00671 266835004081 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 266835004082 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 266835004083 Uncharacterized bacterial proteins with similarity to Aminoglycoside 3'-phosphotransferase (APH) and Choline kinase (ChoK) family members. The APH/ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases; Region: APH_ChoK_like_1; cd05155 266835004084 Phosphotransferase enzyme family; Region: APH; pfam01636 266835004085 putative active site [active] 266835004086 putative substrate binding site [chemical binding]; other site 266835004087 ATP binding site [chemical binding]; other site 266835004088 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 266835004089 Domain of unknown function DUF20; Region: UPF0118; pfam01594 266835004090 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 266835004091 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 266835004092 ATP-grasp domain; Region: ATP-grasp_4; cl17255 266835004093 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 266835004094 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 266835004095 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266835004096 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 266835004097 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 266835004098 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266835004099 homodimer interface [polypeptide binding]; other site 266835004100 catalytic residue [active] 266835004101 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 266835004102 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 266835004103 Coenzyme A binding pocket [chemical binding]; other site 266835004104 Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467 266835004105 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 266835004106 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266835004107 DNA-binding site [nucleotide binding]; DNA binding site 266835004108 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 266835004109 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266835004110 homodimer interface [polypeptide binding]; other site 266835004111 catalytic residue [active] 266835004112 Predicted secreted Zn-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5664 266835004113 Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545 266835004114 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 266835004115 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266835004116 putative DNA binding site [nucleotide binding]; other site 266835004117 dimerization interface [polypeptide binding]; other site 266835004118 putative Zn2+ binding site [ion binding]; other site 266835004119 AsnC family; Region: AsnC_trans_reg; pfam01037 266835004120 Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150 266835004121 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 266835004122 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266835004123 metal binding site [ion binding]; metal-binding site 266835004124 active site 266835004125 I-site; other site 266835004126 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 266835004127 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 266835004128 putative NAD(P) binding site [chemical binding]; other site 266835004129 putative active site [active] 266835004130 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 266835004131 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266835004132 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 266835004133 dimerization interface [polypeptide binding]; other site 266835004134 substrate binding pocket [chemical binding]; other site 266835004135 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 266835004136 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266835004137 binding surface 266835004138 TPR motif; other site 266835004139 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 266835004140 hydroxyglutarate oxidase; Provisional; Region: PRK11728 266835004141 Predicted membrane protein [Function unknown]; Region: COG3619 266835004142 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 266835004143 MarR family; Region: MarR; pfam01047 266835004144 p-hydroxycinnamoyl CoA hydratase/lyase; Validated; Region: PRK09120 266835004145 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266835004146 substrate binding site [chemical binding]; other site 266835004147 oxyanion hole (OAH) forming residues; other site 266835004148 trimer interface [polypeptide binding]; other site 266835004149 acyl-CoA synthetase; Validated; Region: PRK09088 266835004150 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 266835004151 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 266835004152 acyl-activating enzyme (AAE) consensus motif; other site 266835004153 acyl-activating enzyme (AAE) consensus motif; other site 266835004154 putative AMP binding site [chemical binding]; other site 266835004155 putative active site [active] 266835004156 putative CoA binding site [chemical binding]; other site 266835004157 Uncharacterized conserved protein [Function unknown]; Region: COG3246 266835004158 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266835004159 PAS fold; Region: PAS_3; pfam08447 266835004160 putative active site [active] 266835004161 heme pocket [chemical binding]; other site 266835004162 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 266835004163 PAS fold; Region: PAS_3; pfam08447 266835004164 putative active site [active] 266835004165 heme pocket [chemical binding]; other site 266835004166 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266835004167 metal binding site [ion binding]; metal-binding site 266835004168 active site 266835004169 I-site; other site 266835004170 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 266835004171 SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366 266835004172 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 266835004173 active site 266835004174 The Sema domain, a protein interacting module, of semaphorins and plexins; Region: Sema; cl15693 266835004175 Uncharacterized conserved protein [Function unknown]; Region: COG5470 266835004176 Predicted transcriptional regulators [Transcription]; Region: COG1733 266835004177 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266835004178 dimerization interface [polypeptide binding]; other site 266835004179 putative DNA binding site [nucleotide binding]; other site 266835004180 putative Zn2+ binding site [ion binding]; other site 266835004181 Predicted transcription regulator containing HTH domain [Transcription]; Region: COG5499 266835004182 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4680 266835004183 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 266835004184 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 266835004185 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266835004186 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 266835004187 DNA binding site [nucleotide binding] 266835004188 active site 266835004189 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 266835004190 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 266835004191 DNA binding site [nucleotide binding] 266835004192 active site 266835004193 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3826 266835004194 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266835004195 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266835004196 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 266835004197 putative effector binding pocket; other site 266835004198 dimerization interface [polypeptide binding]; other site 266835004199 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 266835004200 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 266835004201 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 266835004202 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 266835004203 DNA binding residues [nucleotide binding] 266835004204 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 266835004205 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 266835004206 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 266835004207 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 266835004208 NADP binding site [chemical binding]; other site 266835004209 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 266835004210 RibD C-terminal domain; Region: RibD_C; pfam01872 266835004211 Predicted transcriptional regulators [Transcription]; Region: COG1733 266835004212 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 266835004213 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4312 266835004214 DNA polymerase IV; Validated; Region: PRK03858 266835004215 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 266835004216 active site 266835004217 DNA binding site [nucleotide binding] 266835004218 GTPase RsgA; Reviewed; Region: PRK01889 266835004219 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 266835004220 GTPase/Zn-binding domain interface [polypeptide binding]; other site 266835004221 GTP/Mg2+ binding site [chemical binding]; other site 266835004222 G4 box; other site 266835004223 G5 box; other site 266835004224 G1 box; other site 266835004225 Switch I region; other site 266835004226 G2 box; other site 266835004227 G3 box; other site 266835004228 Switch II region; other site 266835004229 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 266835004230 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 266835004231 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_5; cd04662 266835004232 nudix motif; other site 266835004233 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 266835004234 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 266835004235 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 266835004236 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 266835004237 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 266835004238 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 266835004239 putative active site [active] 266835004240 short chain dehydrogenase; Provisional; Region: PRK06198 266835004241 classical (c) SDRs; Region: SDR_c; cd05233 266835004242 NAD(P) binding site [chemical binding]; other site 266835004243 active site 266835004244 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 266835004245 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 266835004246 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 266835004247 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 266835004248 Periplasmic sugar-binding component of uncharacterized ABC-type transport systems that are members of the pentose/hexose sugar-binding protein family of the type I periplasmic binding protein superfamily; Region: PBP1_ABC_sugar_binding_like_1; cd06300 266835004249 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 266835004250 putative ligand binding site [chemical binding]; other site 266835004251 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 266835004252 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 266835004253 Walker A/P-loop; other site 266835004254 ATP binding site [chemical binding]; other site 266835004255 Q-loop/lid; other site 266835004256 ABC transporter signature motif; other site 266835004257 Walker B; other site 266835004258 D-loop; other site 266835004259 H-loop/switch region; other site 266835004260 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 266835004261 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 266835004262 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 266835004263 TM-ABC transporter signature motif; other site 266835004264 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 266835004265 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 266835004266 TM-ABC transporter signature motif; other site 266835004267 Predicted methyltransferase [General function prediction only]; Region: COG4798 266835004268 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 266835004269 NmrA (a transcriptional regulator) and triphenylmethane reductase (TMR) like proteins, subgroup 1, atypical (a) SDRs; Region: NmrA_TMR_like_1_SDR_a; cd05231 266835004270 putative NADP binding site [chemical binding]; other site 266835004271 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 266835004272 MarR family; Region: MarR_2; pfam12802 266835004273 short chain dehydrogenase; Provisional; Region: PRK06482 266835004274 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 266835004275 NADP binding site [chemical binding]; other site 266835004276 active site 266835004277 steroid binding site; other site 266835004278 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 266835004279 Methyltransferase domain; Region: Methyltransf_31; pfam13847 266835004280 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266835004281 HerA helicase [Replication, recombination, and repair]; Region: COG0433 266835004282 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 266835004283 Walker A motif; other site 266835004284 ATP binding site [chemical binding]; other site 266835004285 Walker B motif; other site 266835004286 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 266835004287 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 266835004288 C-terminal domain interface [polypeptide binding]; other site 266835004289 GSH binding site (G-site) [chemical binding]; other site 266835004290 dimer interface [polypeptide binding]; other site 266835004291 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 266835004292 N-terminal domain interface [polypeptide binding]; other site 266835004293 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 266835004294 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 266835004295 active site 266835004296 catalytic tetrad [active] 266835004297 Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988 266835004298 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276 266835004299 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 266835004300 putative NAD(P) binding site [chemical binding]; other site 266835004301 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 266835004302 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 266835004303 Walker A/P-loop; other site 266835004304 ATP binding site [chemical binding]; other site 266835004305 Q-loop/lid; other site 266835004306 ABC transporter signature motif; other site 266835004307 Walker B; other site 266835004308 D-loop; other site 266835004309 H-loop/switch region; other site 266835004310 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_7; cd06316 266835004311 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 266835004312 putative ligand binding site [chemical binding]; other site 266835004313 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 266835004314 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 266835004315 TM-ABC transporter signature motif; other site 266835004316 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 266835004317 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 266835004318 Walker A/P-loop; other site 266835004319 ATP binding site [chemical binding]; other site 266835004320 Q-loop/lid; other site 266835004321 ABC transporter signature motif; other site 266835004322 Walker B; other site 266835004323 D-loop; other site 266835004324 H-loop/switch region; other site 266835004325 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 266835004326 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 266835004327 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 266835004328 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 266835004329 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266835004330 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266835004331 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 266835004332 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 266835004333 catalytic loop [active] 266835004334 iron binding site [ion binding]; other site 266835004335 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 266835004336 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 266835004337 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 266835004338 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 266835004339 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 266835004340 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 266835004341 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276 266835004342 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 266835004343 putative NAD(P) binding site [chemical binding]; other site 266835004344 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266835004345 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266835004346 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 266835004347 putative effector binding pocket; other site 266835004348 dimerization interface [polypeptide binding]; other site 266835004349 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 266835004350 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 266835004351 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 266835004352 Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_1; cd07020 266835004353 dimer interface [polypeptide binding]; other site 266835004354 active site residues [active] 266835004355 NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957 266835004356 DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771 266835004357 Uncharacterized protein with a C-terminal OMP (outer membrane protein) domain [Function unknown]; Region: COG4625 266835004358 Autotransporter beta-domain; Region: Autotransporter; pfam03797 266835004359 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 266835004360 EamA-like transporter family; Region: EamA; pfam00892 266835004361 Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555 266835004362 Response regulator receiver domain; Region: Response_reg; pfam00072 266835004363 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266835004364 active site 266835004365 phosphorylation site [posttranslational modification] 266835004366 intermolecular recognition site; other site 266835004367 dimerization interface [polypeptide binding]; other site 266835004368 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 266835004369 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 266835004370 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 266835004371 active site 266835004372 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 266835004373 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 266835004374 active site 266835004375 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 266835004376 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 266835004377 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266835004378 Walker A/P-loop; other site 266835004379 ATP binding site [chemical binding]; other site 266835004380 Q-loop/lid; other site 266835004381 ABC transporter signature motif; other site 266835004382 Walker B; other site 266835004383 D-loop; other site 266835004384 H-loop/switch region; other site 266835004385 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 266835004386 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 266835004387 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 266835004388 Switch I; other site 266835004389 Switch II; other site 266835004390 Septum formation inhibitor [Cell division and chromosome partitioning]; Region: MinC; COG0850 266835004391 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 266835004392 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 266835004393 active site 266835004394 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 266835004395 catalytic tetrad [active] 266835004396 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266835004397 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266835004398 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4316 266835004399 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 266835004400 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 266835004401 Protein of unknown function (DUF2934); Region: DUF2934; pfam11154 266835004402 BA14K-like protein; Region: BA14K; pfam07886 266835004403 BA14K-like protein; Region: BA14K; pfam07886 266835004404 Predicted membrane protein [Function unknown]; Region: COG2259 266835004405 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266835004406 TPR motif; other site 266835004407 TPR repeat; Region: TPR_11; pfam13414 266835004408 binding surface 266835004409 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 266835004410 Protein of unknown function (DUF680); Region: DUF680; pfam05079 266835004411 Protein of unknown function (DUF680); Region: DUF680; pfam05079 266835004412 The adenylation (A) domain of siderophore-synthesizing nonribosomal peptide synthetases (NRPS); Region: A_NRPS_SidN3_like; cd05918 266835004413 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 266835004414 acyl-activating enzyme (AAE) consensus motif; other site 266835004415 AMP binding site [chemical binding]; other site 266835004416 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 266835004417 non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353 266835004418 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 266835004419 putative trimer interface [polypeptide binding]; other site 266835004420 putative CoA binding site [chemical binding]; other site 266835004421 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 266835004422 putative trimer interface [polypeptide binding]; other site 266835004423 putative CoA binding site [chemical binding]; other site 266835004424 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 266835004425 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 266835004426 Coenzyme A binding pocket [chemical binding]; other site 266835004427 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 266835004428 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 266835004429 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 266835004430 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 266835004431 FeS/SAM binding site; other site 266835004432 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 266835004433 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 266835004434 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266835004435 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 266835004436 dimerization interface [polypeptide binding]; other site 266835004437 substrate binding pocket [chemical binding]; other site 266835004438 aldehyde reductase, extended (e) SDRs; Region: AR_SDR_e; cd05227 266835004439 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 266835004440 NADP binding site [chemical binding]; other site 266835004441 putative substrate binding site [chemical binding]; other site 266835004442 active site 266835004443 Cupin; Region: Cupin_6; pfam12852 266835004444 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 266835004445 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266835004446 Uncharacterized protein, 4-oxalocrotonate tautomerase homolog [General function prediction only]; Region: COG1942 266835004447 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 266835004448 NADP binding site [chemical binding]; other site 266835004449 active site 266835004450 steroid binding site; other site 266835004451 short chain dehydrogenase; Provisional; Region: PRK12937 266835004452 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 266835004453 NADP binding site [chemical binding]; other site 266835004454 homodimer interface [polypeptide binding]; other site 266835004455 active site 266835004456 substrate binding site [chemical binding]; other site 266835004457 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266835004458 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266835004459 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 266835004460 putative effector binding pocket; other site 266835004461 putative dimerization interface [polypeptide binding]; other site 266835004462 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 266835004463 Type I periplasmic components of amide-binding protein (AmiC) and the active transport system for short-chain and urea (FmdDEF); Region: PBP1_AmiC_like; cd06331 266835004464 ligand binding site [chemical binding]; other site 266835004465 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 266835004466 HD domain; Region: HD_5; pfam13487 266835004467 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 266835004468 Zn2+ binding site [ion binding]; other site 266835004469 Mg2+ binding site [ion binding]; other site 266835004470 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 266835004471 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266835004472 DNA binding residues [nucleotide binding] 266835004473 dimerization interface [polypeptide binding]; other site 266835004474 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835004475 NmrA-like family; Region: NmrA; pfam05368 266835004476 NAD(P) binding site [chemical binding]; other site 266835004477 active site 266835004478 DoxX-like family; Region: DoxX_2; pfam13564 266835004479 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266835004480 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266835004481 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 266835004482 putative effector binding pocket; other site 266835004483 putative dimerization interface [polypeptide binding]; other site 266835004484 Predicted deacylase [General function prediction only]; Region: COG3608 266835004485 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_1; cd06251 266835004486 putative active site [active] 266835004487 Zn binding site [ion binding]; other site 266835004488 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 266835004489 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 266835004490 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 266835004491 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 266835004492 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 266835004493 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266835004494 DNA binding residues [nucleotide binding] 266835004495 dimerization interface [polypeptide binding]; other site 266835004496 Predicted integral membrane protein [Function unknown]; Region: COG5616 266835004497 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266835004498 TPR motif; other site 266835004499 binding surface 266835004500 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266835004501 TPR motif; other site 266835004502 binding surface 266835004503 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 266835004504 Beta-lactamase; Region: Beta-lactamase; pfam00144 266835004505 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 266835004506 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 266835004507 Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); Region: MACS_like_2; cd05973 266835004508 active site 266835004509 acyl-activating enzyme (AAE) consensus motif; other site 266835004510 putative CoA binding site [chemical binding]; other site 266835004511 AMP binding site [chemical binding]; other site 266835004512 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 266835004513 active site 266835004514 tetramer interface [polypeptide binding]; other site 266835004515 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 266835004516 heat shock protein 90; Provisional; Region: PRK05218 266835004517 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266835004518 ATP binding site [chemical binding]; other site 266835004519 Mg2+ binding site [ion binding]; other site 266835004520 G-X-G motif; other site 266835004521 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 266835004522 Serine hydrolase; Region: Ser_hydrolase; cl17834 266835004523 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266835004524 DNA binding site [nucleotide binding] 266835004525 Predicted integral membrane protein [Function unknown]; Region: COG5616 266835004526 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266835004527 TPR motif; other site 266835004528 binding surface 266835004529 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835004530 dimer interface [polypeptide binding]; other site 266835004531 conserved gate region; other site 266835004532 putative PBP binding loops; other site 266835004533 ABC-ATPase subunit interface; other site 266835004534 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 266835004535 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835004536 dimer interface [polypeptide binding]; other site 266835004537 conserved gate region; other site 266835004538 putative PBP binding loops; other site 266835004539 ABC-ATPase subunit interface; other site 266835004540 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 266835004541 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 266835004542 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 266835004543 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266835004544 Walker A/P-loop; other site 266835004545 ATP binding site [chemical binding]; other site 266835004546 Q-loop/lid; other site 266835004547 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 266835004548 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266835004549 ABC transporter signature motif; other site 266835004550 Walker B; other site 266835004551 D-loop; other site 266835004552 H-loop/switch region; other site 266835004553 TOBE domain; Region: TOBE_2; pfam08402 266835004554 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 266835004555 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 266835004556 conserved cys residue [active] 266835004557 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266835004558 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266835004559 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3452 266835004560 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266835004561 PAS fold; Region: PAS_3; pfam08447 266835004562 putative active site [active] 266835004563 heme pocket [chemical binding]; other site 266835004564 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 266835004565 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266835004566 metal binding site [ion binding]; metal-binding site 266835004567 active site 266835004568 I-site; other site 266835004569 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 266835004570 hypothetical protein; Provisional; Region: PRK06834 266835004571 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 266835004572 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 266835004573 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 266835004574 putative C-terminal domain interface [polypeptide binding]; other site 266835004575 putative GSH binding site (G-site) [chemical binding]; other site 266835004576 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 266835004577 putative dimer interface [polypeptide binding]; other site 266835004578 C-terminal, alpha helical domain of an unknown subfamily 8 of Glutathione S-transferases; Region: GST_C_8; cd03207 266835004579 dimer interface [polypeptide binding]; other site 266835004580 N-terminal domain interface [polypeptide binding]; other site 266835004581 putative substrate binding pocket (H-site) [chemical binding]; other site 266835004582 The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cl01109 266835004583 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_7; cd08353 266835004584 putative dimer interface [polypeptide binding]; other site 266835004585 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266835004586 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 266835004587 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 266835004588 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266835004589 Walker A/P-loop; other site 266835004590 ATP binding site [chemical binding]; other site 266835004591 Q-loop/lid; other site 266835004592 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 266835004593 ABC transporter signature motif; other site 266835004594 Walker B; other site 266835004595 D-loop; other site 266835004596 ABC transporter; Region: ABC_tran_2; pfam12848 266835004597 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 266835004598 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 266835004599 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 266835004600 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 266835004601 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835004602 NAD(P) binding site [chemical binding]; other site 266835004603 active site 266835004604 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 266835004605 GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056 266835004606 putative C-terminal domain interface [polypeptide binding]; other site 266835004607 putative GSH binding site (G-site) [chemical binding]; other site 266835004608 putative dimer interface [polypeptide binding]; other site 266835004609 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 266835004610 N-terminal domain interface [polypeptide binding]; other site 266835004611 dimer interface [polypeptide binding]; other site 266835004612 substrate binding pocket (H-site) [chemical binding]; other site 266835004613 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 266835004614 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 266835004615 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 266835004616 Transcriptional regulators [Transcription]; Region: MarR; COG1846 266835004617 MarR family; Region: MarR_2; pfam12802 266835004618 Lin1944 and related proteins, classical (c) SDRs; Region: Lin1944_like_SDR_c; cd11731 266835004619 short chain dehydrogenase; Provisional; Region: PRK07041 266835004620 putative NAD(P) binding site [chemical binding]; other site 266835004621 homodimer interface [polypeptide binding]; other site 266835004622 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266835004623 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266835004624 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 266835004625 dimerization interface [polypeptide binding]; other site 266835004626 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 266835004627 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 266835004628 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 266835004629 protein binding site [polypeptide binding]; other site 266835004630 putative S-transferase; Provisional; Region: PRK11752 266835004631 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 266835004632 C-terminal domain interface [polypeptide binding]; other site 266835004633 GSH binding site (G-site) [chemical binding]; other site 266835004634 dimer interface [polypeptide binding]; other site 266835004635 C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292 266835004636 dimer interface [polypeptide binding]; other site 266835004637 N-terminal domain interface [polypeptide binding]; other site 266835004638 active site 266835004639 Protein of unknown function (DUF1236); Region: DUF1236; pfam06823 266835004640 Exopolysaccharide production repressor; Region: SyrA; pfam11089 266835004641 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 266835004642 cytosine deaminase; Provisional; Region: PRK05985 266835004643 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 266835004644 active site 266835004645 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 266835004646 catalytic triad [active] 266835004647 mobile mystery protein B; Region: mob_myst_B; TIGR02613 266835004648 Fic/DOC family; Region: Fic; pfam02661 266835004649 mobile mystery protein A; Region: mob_myst_A; TIGR02612 266835004650 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266835004651 non-specific DNA binding site [nucleotide binding]; other site 266835004652 salt bridge; other site 266835004653 sequence-specific DNA binding site [nucleotide binding]; other site 266835004654 FOG: WD40 repeat [General function prediction only]; Region: COG2319 266835004655 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 266835004656 structural tetrad; other site 266835004657 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 266835004658 putative catalytic site [active] 266835004659 putative phosphate binding site [ion binding]; other site 266835004660 active site 266835004661 metal binding site A [ion binding]; metal-binding site 266835004662 DNA binding site [nucleotide binding] 266835004663 putative AP binding site [nucleotide binding]; other site 266835004664 putative metal binding site B [ion binding]; other site 266835004665 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG3571 266835004666 PGAP1-like protein; Region: PGAP1; pfam07819 266835004667 TPR repeat; Region: TPR_11; pfam13414 266835004668 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266835004669 binding surface 266835004670 TPR motif; other site 266835004671 TPR repeat; Region: TPR_11; pfam13414 266835004672 Ku-homolog [Replication, recombination, and repair]; Region: COG1273 266835004673 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 266835004674 putative DNA binding site [nucleotide binding]; other site 266835004675 putative homodimer interface [polypeptide binding]; other site 266835004676 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448 266835004677 GIY-YIG motif/motif A; other site 266835004678 putative active site [active] 266835004679 putative metal binding site [ion binding]; other site 266835004680 ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK05972 266835004681 DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777 266835004682 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 266835004683 active site 266835004684 DNA binding site [nucleotide binding] 266835004685 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 266835004686 DNA binding site [nucleotide binding] 266835004687 PaeLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: PaeLigD_Pol_like; cd04862 266835004688 nucleotide binding site [chemical binding]; other site 266835004689 conserved hypothetical protein; Region: TIGR02118 266835004690 Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653 266835004691 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 266835004692 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 266835004693 Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653 266835004694 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 266835004695 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 266835004696 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 266835004697 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_6; cd04955 266835004698 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 266835004699 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 266835004700 chain length determinant protein EpsF; Region: EpsF; TIGR03017 266835004701 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 266835004702 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 266835004703 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 266835004704 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 266835004705 Transcriptional regulators [Transcription]; Region: PurR; COG1609 266835004706 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 266835004707 DNA binding site [nucleotide binding] 266835004708 domain linker motif; other site 266835004709 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 266835004710 dimerization interface [polypeptide binding]; other site 266835004711 ligand binding site [chemical binding]; other site 266835004712 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_8; cd12167 266835004713 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 266835004714 putative ligand binding site [chemical binding]; other site 266835004715 putative NAD binding site [chemical binding]; other site 266835004716 catalytic site [active] 266835004717 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237 266835004718 hydroperoxidase II; Provisional; Region: katE; PRK11249 266835004719 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 266835004720 heme binding pocket [chemical binding]; other site 266835004721 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 266835004722 domain interactions; other site 266835004723 Predicted small integral membrane protein [Function unknown]; Region: COG5478 266835004724 Low affinity iron permease; Region: Iron_permease; pfam04120 266835004725 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 266835004726 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 266835004727 ligand binding site [chemical binding]; other site 266835004728 flexible hinge region; other site 266835004729 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 266835004730 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 266835004731 sequence-specific DNA binding site [nucleotide binding]; other site 266835004732 salt bridge; other site 266835004733 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266835004734 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 266835004735 DNA-binding site [nucleotide binding]; DNA binding site 266835004736 FCD domain; Region: FCD; pfam07729 266835004737 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 266835004738 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 266835004739 putative NAD(P) binding site [chemical binding]; other site 266835004740 short chain dehydrogenase; Provisional; Region: PRK06179 266835004741 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 266835004742 NADP binding site [chemical binding]; other site 266835004743 active site 266835004744 steroid binding site; other site 266835004745 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266835004746 Predicted membrane protein [Function unknown]; Region: COG5395 266835004747 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 266835004748 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3756 266835004749 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266835004750 non-specific DNA binding site [nucleotide binding]; other site 266835004751 salt bridge; other site 266835004752 sequence-specific DNA binding site [nucleotide binding]; other site 266835004753 Predicted transcriptional regulator [Transcription]; Region: COG2932 266835004754 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 266835004755 Catalytic site [active] 266835004756 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 266835004757 catalytic core [active] 266835004758 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 266835004759 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 266835004760 TM-ABC transporter signature motif; other site 266835004761 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 266835004762 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 266835004763 Walker A/P-loop; other site 266835004764 ATP binding site [chemical binding]; other site 266835004765 Q-loop/lid; other site 266835004766 ABC transporter signature motif; other site 266835004767 Walker B; other site 266835004768 D-loop; other site 266835004769 H-loop/switch region; other site 266835004770 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 266835004771 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 266835004772 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 266835004773 Predicted RNA binding protein (dsRBD-like fold), HicA family [General function prediction only]; Region: COG1724 266835004774 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 266835004775 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 266835004776 RibD C-terminal domain; Region: RibD_C; cl17279 266835004777 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 266835004778 atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262 266835004779 putative NAD(P) binding site [chemical binding]; other site 266835004780 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266835004781 salt bridge; other site 266835004782 non-specific DNA binding site [nucleotide binding]; other site 266835004783 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 266835004784 sequence-specific DNA binding site [nucleotide binding]; other site 266835004785 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 266835004786 putative hydrophobic ligand binding site [chemical binding]; other site 266835004787 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3453 266835004788 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 266835004789 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266835004790 dimerization interface [polypeptide binding]; other site 266835004791 putative DNA binding site [nucleotide binding]; other site 266835004792 Transcriptional regulators [Transcription]; Region: MarR; COG1846 266835004793 putative Zn2+ binding site [ion binding]; other site 266835004794 Predicted transporter component [General function prediction only]; Region: COG2391 266835004795 Predicted transporter component [General function prediction only]; Region: COG2391 266835004796 Domain of unknown function (DUF4341); Region: DUF4341; pfam14241 266835004797 Methyltransferase domain; Region: Methyltransf_23; pfam13489 266835004798 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266835004799 S-adenosylmethionine binding site [chemical binding]; other site 266835004800 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 266835004801 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266835004802 dimerization interface [polypeptide binding]; other site 266835004803 putative DNA binding site [nucleotide binding]; other site 266835004804 putative Zn2+ binding site [ion binding]; other site 266835004805 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 266835004806 ArsC family; Region: ArsC; pfam03960 266835004807 catalytic residues [active] 266835004808 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 266835004809 amphipathic channel; other site 266835004810 Asn-Pro-Ala signature motifs; other site 266835004811 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266835004812 dimerization interface [polypeptide binding]; other site 266835004813 putative DNA binding site [nucleotide binding]; other site 266835004814 putative Zn2+ binding site [ion binding]; other site 266835004815 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266835004816 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266835004817 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 266835004818 putative effector binding pocket; other site 266835004819 putative dimerization interface [polypeptide binding]; other site 266835004820 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 266835004821 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 266835004822 active site 266835004823 catalytic tetrad [active] 266835004824 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266835004825 dimerization interface [polypeptide binding]; other site 266835004826 putative DNA binding site [nucleotide binding]; other site 266835004827 putative Zn2+ binding site [ion binding]; other site 266835004828 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 266835004829 putative hydrophobic ligand binding site [chemical binding]; other site 266835004830 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 266835004831 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 266835004832 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 266835004833 active site 266835004834 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 266835004835 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 266835004836 SnoaL-like domain; Region: SnoaL_3; pfam13474 266835004837 short chain dehydrogenase; Provisional; Region: PRK12829 266835004838 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835004839 active site 266835004840 RNA polymerase sigma-70 factor, TIGR02960 family; Region: SigX5 266835004841 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 266835004842 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 266835004843 DNA binding residues [nucleotide binding] 266835004844 SnoaL-like domain; Region: SnoaL_2; pfam12680 266835004845 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 266835004846 active site 266835004847 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266835004848 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 266835004849 catalytic core [active] 266835004850 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 266835004851 Sulfatase; Region: Sulfatase; cl17466 266835004852 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VirK; COG2990 266835004853 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 266835004854 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 266835004855 active site 266835004856 substrate binding site [chemical binding]; other site 266835004857 trimer interface [polypeptide binding]; other site 266835004858 CoA binding site [chemical binding]; other site 266835004859 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266835004860 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266835004861 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266835004862 dimerization interface [polypeptide binding]; other site 266835004863 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266835004864 Porcine testicular carbonyl reductase (PTCR)-like, classical (c) SDRs; Region: carb_red_PTCR-like_SDR_c; cd05324 266835004865 short chain dehydrogenase; Provisional; Region: PRK07454 266835004866 NADP binding site [chemical binding]; other site 266835004867 substrate binding site [chemical binding]; other site 266835004868 active site 266835004869 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 266835004870 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 266835004871 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266835004872 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 266835004873 AsnC family; Region: AsnC_trans_reg; pfam01037 266835004874 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 266835004875 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 266835004876 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 266835004877 substrate binding pocket [chemical binding]; other site 266835004878 membrane-bound complex binding site; other site 266835004879 hinge residues; other site 266835004880 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 266835004881 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835004882 dimer interface [polypeptide binding]; other site 266835004883 conserved gate region; other site 266835004884 putative PBP binding loops; other site 266835004885 ABC-ATPase subunit interface; other site 266835004886 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 266835004887 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 266835004888 Walker A/P-loop; other site 266835004889 ATP binding site [chemical binding]; other site 266835004890 Q-loop/lid; other site 266835004891 ABC transporter signature motif; other site 266835004892 Walker B; other site 266835004893 D-loop; other site 266835004894 H-loop/switch region; other site 266835004895 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain [Transcription]; Region: COG3609 266835004896 TPR repeat; Region: TPR_11; pfam13414 266835004897 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266835004898 binding surface 266835004899 TPR motif; other site 266835004900 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 266835004901 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266835004902 binding surface 266835004903 TPR motif; other site 266835004904 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266835004905 binding surface 266835004906 TPR motif; other site 266835004907 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266835004908 binding surface 266835004909 TPR motif; other site 266835004910 lipoprotein NlpI; Provisional; Region: PRK11189 266835004911 TPR repeat; Region: TPR_11; pfam13414 266835004912 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266835004913 binding surface 266835004914 TPR motif; other site 266835004915 TPR repeat; Region: TPR_11; pfam13414 266835004916 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 266835004917 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266835004918 binding surface 266835004919 TPR motif; other site 266835004920 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266835004921 binding surface 266835004922 TPR motif; other site 266835004923 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266835004924 binding surface 266835004925 TPR motif; other site 266835004926 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266835004927 binding surface 266835004928 TPR motif; other site 266835004929 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266835004930 TPR repeat; Region: TPR_11; pfam13414 266835004931 binding surface 266835004932 TPR motif; other site 266835004933 lipoprotein NlpI; Provisional; Region: PRK11189 266835004934 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 266835004935 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 266835004936 FMN binding site [chemical binding]; other site 266835004937 active site 266835004938 substrate binding site [chemical binding]; other site 266835004939 catalytic residue [active] 266835004940 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266835004941 dimerization interface [polypeptide binding]; other site 266835004942 putative DNA binding site [nucleotide binding]; other site 266835004943 putative Zn2+ binding site [ion binding]; other site 266835004944 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266835004945 Walker B; other site 266835004946 RES domain; Region: RES; smart00953 266835004947 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 266835004948 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 266835004949 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 266835004950 NAD binding site [chemical binding]; other site 266835004951 catalytic residues [active] 266835004952 Uncharacterized conserved protein [Function unknown]; Region: COG3603 266835004953 Family description; Region: ACT_7; pfam13840 266835004954 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 266835004955 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 266835004956 Coenzyme A binding pocket [chemical binding]; other site 266835004957 Predicted ester cyclase [General function prediction only]; Region: COG5485 266835004958 Predicted membrane protein [Function unknown]; Region: COG2855 266835004959 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 266835004960 GAF domain; Region: GAF_2; pfam13185 266835004961 Uncharacterized conserved protein [Function unknown]; Region: COG4274 266835004962 chaperonin GroEL; Reviewed; Region: groEL; PRK12850 266835004963 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 266835004964 ring oligomerisation interface [polypeptide binding]; other site 266835004965 ATP/Mg binding site [chemical binding]; other site 266835004966 stacking interactions; other site 266835004967 hinge regions; other site 266835004968 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 266835004969 oligomerisation interface [polypeptide binding]; other site 266835004970 mobile loop; other site 266835004971 roof hairpin; other site 266835004972 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 266835004973 PAS domain; Region: PAS_9; pfam13426 266835004974 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 266835004975 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266835004976 metal binding site [ion binding]; metal-binding site 266835004977 active site 266835004978 I-site; other site 266835004979 Transcriptional regulators [Transcription]; Region: PurR; COG1609 266835004980 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 266835004981 DNA binding site [nucleotide binding] 266835004982 domain linker motif; other site 266835004983 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 266835004984 dimerization interface [polypeptide binding]; other site 266835004985 ligand binding site [chemical binding]; other site 266835004986 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 266835004987 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 266835004988 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 266835004989 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835004990 putative PBP binding loops; other site 266835004991 ABC-ATPase subunit interface; other site 266835004992 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 266835004993 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835004994 dimer interface [polypeptide binding]; other site 266835004995 conserved gate region; other site 266835004996 putative PBP binding loops; other site 266835004997 ABC-ATPase subunit interface; other site 266835004998 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 266835004999 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 266835005000 Predicted membrane protein [Function unknown]; Region: COG4763 266835005001 Acyltransferase family; Region: Acyl_transf_3; pfam01757 266835005002 Uncharacterized conserved protein [Function unknown]; Region: COG5649 266835005003 Uncharacterized conserved protein [Function unknown]; Region: COG5649 266835005004 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266835005005 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 266835005006 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 266835005007 putative hydrophobic ligand binding site [chemical binding]; other site 266835005008 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266835005009 dimerization interface [polypeptide binding]; other site 266835005010 putative DNA binding site [nucleotide binding]; other site 266835005011 putative Zn2+ binding site [ion binding]; other site 266835005012 Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703 266835005013 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 266835005014 putative active site pocket [active] 266835005015 dimerization interface [polypeptide binding]; other site 266835005016 putative catalytic residue [active] 266835005017 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 266835005018 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 266835005019 putative dimer interface [polypeptide binding]; other site 266835005020 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266835005021 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 266835005022 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 266835005023 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266835005024 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266835005025 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 266835005026 dimerization interface [polypeptide binding]; other site 266835005027 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266835005028 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 266835005029 Eukaryotic cytochrome b(561); Region: Cyt_b561; cl14616 266835005030 putative heme binding sites [chemical binding]; other site 266835005031 Lysozyme family protein [General function prediction only]; Region: zliS; COG3926 266835005032 Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838 266835005033 Predicted integral membrane protein [Function unknown]; Region: COG5530 266835005034 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 266835005035 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 266835005036 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 266835005037 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 266835005038 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 266835005039 DNA binding residues [nucleotide binding] 266835005040 SnoaL-like domain; Region: SnoaL_2; pfam12680 266835005041 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 266835005042 classical (c) SDRs; Region: SDR_c; cd05233 266835005043 NAD(P) binding site [chemical binding]; other site 266835005044 active site 266835005045 D-ala-D-ala transporter subunit; Provisional; Region: PRK09881 266835005046 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835005047 dimer interface [polypeptide binding]; other site 266835005048 conserved gate region; other site 266835005049 putative PBP binding loops; other site 266835005050 ABC-ATPase subunit interface; other site 266835005051 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 266835005052 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835005053 ABC-ATPase subunit interface; other site 266835005054 putative PBP binding loops; other site 266835005055 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 266835005056 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 266835005057 Domain of unknown function (DUF427); Region: DUF427; pfam04248 266835005058 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 266835005059 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 266835005060 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 266835005061 active site 266835005062 non-prolyl cis peptide bond; other site 266835005063 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 266835005064 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266835005065 Walker A/P-loop; other site 266835005066 ATP binding site [chemical binding]; other site 266835005067 Q-loop/lid; other site 266835005068 ABC transporter signature motif; other site 266835005069 Walker B; other site 266835005070 D-loop; other site 266835005071 H-loop/switch region; other site 266835005072 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 266835005073 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266835005074 Walker A/P-loop; other site 266835005075 ATP binding site [chemical binding]; other site 266835005076 Q-loop/lid; other site 266835005077 ABC transporter signature motif; other site 266835005078 Walker B; other site 266835005079 D-loop; other site 266835005080 H-loop/switch region; other site 266835005081 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 266835005082 Aromatic ring-cleaving dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: DodA; COG3805 266835005083 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 266835005084 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 266835005085 Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635 266835005086 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 266835005087 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 266835005088 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 266835005089 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 266835005090 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 266835005091 catalytic loop [active] 266835005092 iron binding site [ion binding]; other site 266835005093 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 266835005094 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 266835005095 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 266835005096 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_2; cd08895 266835005097 putative hydrophobic ligand binding site [chemical binding]; other site 266835005098 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 266835005099 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 266835005100 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like3; cd05668 266835005101 metal binding site [ion binding]; metal-binding site 266835005102 putative dimer interface [polypeptide binding]; other site 266835005103 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 266835005104 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266835005105 metal binding site [ion binding]; metal-binding site 266835005106 active site 266835005107 I-site; other site 266835005108 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 266835005109 Methyltransferase domain; Region: Methyltransf_25; pfam13649 266835005110 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 266835005111 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266835005112 active site 266835005113 phosphorylation site [posttranslational modification] 266835005114 intermolecular recognition site; other site 266835005115 dimerization interface [polypeptide binding]; other site 266835005116 Response regulator receiver domain; Region: Response_reg; pfam00072 266835005117 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266835005118 active site 266835005119 phosphorylation site [posttranslational modification] 266835005120 intermolecular recognition site; other site 266835005121 dimerization interface [polypeptide binding]; other site 266835005122 PAS domain; Region: PAS_9; pfam13426 266835005123 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 266835005124 Histidine kinase; Region: HisKA_2; pfam07568 266835005125 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266835005126 ATP binding site [chemical binding]; other site 266835005127 Mg2+ binding site [ion binding]; other site 266835005128 G-X-G motif; other site 266835005129 Guanosine kinase-like sugar kinases. Found in bacteria and archaea, the guanosine kinase-like group is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: Guanosine_kinase_like; cd01947 266835005130 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 266835005131 substrate binding site [chemical binding]; other site 266835005132 ATP binding site [chemical binding]; other site 266835005133 phosphonate metabolism protein PhnM; Region: phosphono_phnM; TIGR02318 266835005134 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 266835005135 PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306 266835005136 active site 266835005137 amidase; Validated; Region: PRK06565 266835005138 Amidase; Region: Amidase; cl11426 266835005139 Amidase; Region: Amidase; cl11426 266835005140 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 266835005141 trimer interface [polypeptide binding]; other site 266835005142 active site 266835005143 substrate binding site [chemical binding]; other site 266835005144 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 266835005145 CoA binding site [chemical binding]; other site 266835005146 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3828 266835005147 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 266835005148 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 266835005149 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 266835005150 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 266835005151 CoA-transferase family III; Region: CoA_transf_3; pfam02515 266835005152 Domain of unknown function (DUF4366); Region: DUF4366; pfam14283 266835005153 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 266835005154 Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114 266835005155 NAD(P) binding site [chemical binding]; other site 266835005156 catalytic residues [active] 266835005157 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 266835005158 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 266835005159 active site pocket [active] 266835005160 NIPSNAP; Region: NIPSNAP; pfam07978 266835005161 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 266835005162 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 266835005163 active site pocket [active] 266835005164 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 266835005165 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 266835005166 active site pocket [active] 266835005167 Transcriptional regulators [Transcription]; Region: GntR; COG1802 266835005168 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266835005169 DNA-binding site [nucleotide binding]; DNA binding site 266835005170 FCD domain; Region: FCD; pfam07729 266835005171 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 266835005172 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 266835005173 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 266835005174 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835005175 dimer interface [polypeptide binding]; other site 266835005176 conserved gate region; other site 266835005177 putative PBP binding loops; other site 266835005178 ABC-ATPase subunit interface; other site 266835005179 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 266835005180 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 266835005181 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835005182 dimer interface [polypeptide binding]; other site 266835005183 conserved gate region; other site 266835005184 putative PBP binding loops; other site 266835005185 ABC-ATPase subunit interface; other site 266835005186 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 266835005187 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 266835005188 Walker A/P-loop; other site 266835005189 ATP binding site [chemical binding]; other site 266835005190 Q-loop/lid; other site 266835005191 ABC transporter signature motif; other site 266835005192 Walker B; other site 266835005193 D-loop; other site 266835005194 H-loop/switch region; other site 266835005195 TOBE domain; Region: TOBE; pfam03459 266835005196 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 266835005197 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 266835005198 active site pocket [active] 266835005199 hypothetical protein; Validated; Region: PRK08245 266835005200 Flavin Reductases; Region: FlaRed; cl00801 266835005201 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266835005202 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 266835005203 Walker A motif; other site 266835005204 ATP binding site [chemical binding]; other site 266835005205 Walker B motif; other site 266835005206 arginine finger; other site 266835005207 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266835005208 Walker A motif; other site 266835005209 ATP binding site [chemical binding]; other site 266835005210 Walker B motif; other site 266835005211 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 266835005212 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3515 266835005213 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 266835005214 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3516 266835005215 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517 266835005216 Protein of unknown function (DUF877); Region: DUF877; pfam05943 266835005217 Type VI protein secretion system component Hcp (secreted cytotoxin) [Intracellular trafficking, secretion, and vesicular transport]; Region: Hcp; COG3157 266835005218 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3518 266835005219 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 266835005220 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 266835005221 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3520 266835005222 Predicted component of the type VI protein secretion system, contains a FHA domain [Intracellular trafficking, secretion, and vesicular transport; Signal transduction mechanisms]; Region: COG3456 266835005223 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 266835005224 phosphopeptide binding site; other site 266835005225 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3521 266835005226 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3522 266835005227 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 266835005228 hypothetical protein; Provisional; Region: PRK07033 266835005229 Type VI protein secretion system component VasF [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3455 266835005230 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 266835005231 ligand binding site [chemical binding]; other site 266835005232 type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348 266835005233 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 266835005234 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 266835005235 Uncharacterized protein conserved in bacteria [Function unknown]; Region: SciT; COG3913 266835005236 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5351 266835005237 3-oxoacyl-(acyl carrier protein) synthase; Validated; Region: PRK06147 266835005238 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 266835005239 Domain of unknown function (DUF4150); Region: DUF4150; pfam13665 266835005240 conserved hypothetical protein; Region: TIGR02270 266835005241 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501 266835005242 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 266835005243 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 266835005244 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 266835005245 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733 266835005246 type VI secretion system FHA domain protein; Region: VI_FHA; TIGR03354 266835005247 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 266835005248 phosphopeptide binding site; other site 266835005249 Type VI protein secretion system component VasF [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3455 266835005250 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 266835005251 ligand binding site [chemical binding]; other site 266835005252 type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348 266835005253 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 266835005254 G1 box; other site 266835005255 GTP/Mg2+ binding site [chemical binding]; other site 266835005256 G2 box; other site 266835005257 G3 box; other site 266835005258 Switch II region; other site 266835005259 G4 box; other site 266835005260 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 266835005261 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 266835005262 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 266835005263 Protein phosphatase 2C; Region: PP2C; pfam00481 266835005264 active site 266835005265 Protein kinase domain; Region: Pkinase; pfam00069 266835005266 Catalytic domain of Protein Kinases; Region: PKc; cd00180 266835005267 active site 266835005268 ATP binding site [chemical binding]; other site 266835005269 substrate binding site [chemical binding]; other site 266835005270 activation loop (A-loop); other site 266835005271 Predicted integral membrane protein [Function unknown]; Region: COG5480 266835005272 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 266835005273 Peptidase family M23; Region: Peptidase_M23; pfam01551 266835005274 Uncharacterized protein containing caspase domain [General function prediction only]; Region: COG4249 266835005275 Caspase domain; Region: Peptidase_C14; pfam00656 266835005276 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 266835005277 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 266835005278 ligand binding site [chemical binding]; other site 266835005279 Uncharacterized protein containing caspase domain [General function prediction only]; Region: COG4249 266835005280 Caspase domain; Region: Peptidase_C14; pfam00656 266835005281 substrate pocket [chemical binding]; other site 266835005282 active site 266835005283 proteolytic cleavage site; other site 266835005284 dimer interface [polypeptide binding]; other site 266835005285 YceI-like domain; Region: YceI; pfam04264 266835005286 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 266835005287 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 266835005288 ligand binding site [chemical binding]; other site 266835005289 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 266835005290 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 266835005291 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 266835005292 Protein of unknown function (DUF1236); Region: DUF1236; pfam06823 266835005293 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 266835005294 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 266835005295 Response regulator receiver domain; Region: Response_reg; pfam00072 266835005296 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266835005297 active site 266835005298 phosphorylation site [posttranslational modification] 266835005299 intermolecular recognition site; other site 266835005300 dimerization interface [polypeptide binding]; other site 266835005301 PAS fold; Region: PAS_3; pfam08447 266835005302 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266835005303 putative active site [active] 266835005304 heme pocket [chemical binding]; other site 266835005305 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266835005306 dimer interface [polypeptide binding]; other site 266835005307 phosphorylation site [posttranslational modification] 266835005308 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266835005309 ATP binding site [chemical binding]; other site 266835005310 Mg2+ binding site [ion binding]; other site 266835005311 G-X-G motif; other site 266835005312 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 266835005313 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266835005314 active site 266835005315 phosphorylation site [posttranslational modification] 266835005316 intermolecular recognition site; other site 266835005317 dimerization interface [polypeptide binding]; other site 266835005318 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 266835005319 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 266835005320 dimerization interface [polypeptide binding]; other site 266835005321 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 266835005322 dimerization interface [polypeptide binding]; other site 266835005323 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 266835005324 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 266835005325 dimerization interface [polypeptide binding]; other site 266835005326 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 266835005327 dimerization interface [polypeptide binding]; other site 266835005328 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 266835005329 dimerization interface [polypeptide binding]; other site 266835005330 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 266835005331 dimerization interface [polypeptide binding]; other site 266835005332 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 266835005333 dimerization interface [polypeptide binding]; other site 266835005334 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 266835005335 dimerization interface [polypeptide binding]; other site 266835005336 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 266835005337 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266835005338 ATP binding site [chemical binding]; other site 266835005339 Mg2+ binding site [ion binding]; other site 266835005340 G-X-G motif; other site 266835005341 Response regulator receiver domain; Region: Response_reg; pfam00072 266835005342 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266835005343 active site 266835005344 phosphorylation site [posttranslational modification] 266835005345 intermolecular recognition site; other site 266835005346 dimerization interface [polypeptide binding]; other site 266835005347 Response regulator receiver domain; Region: Response_reg; pfam00072 266835005348 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266835005349 active site 266835005350 phosphorylation site [posttranslational modification] 266835005351 intermolecular recognition site; other site 266835005352 dimerization interface [polypeptide binding]; other site 266835005353 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 266835005354 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 266835005355 putative dimer interface [polypeptide binding]; other site 266835005356 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 266835005357 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 266835005358 putative dimer interface [polypeptide binding]; other site 266835005359 Usg protein, probable subunit of phosphoribosylanthranilate isomerase [Amino acid transport and metabolism]; Region: COG5425 266835005360 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 266835005361 oligomerisation interface [polypeptide binding]; other site 266835005362 mobile loop; other site 266835005363 roof hairpin; other site 266835005364 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 266835005365 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 266835005366 ring oligomerisation interface [polypeptide binding]; other site 266835005367 ATP/Mg binding site [chemical binding]; other site 266835005368 stacking interactions; other site 266835005369 hinge regions; other site 266835005370 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266835005371 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266835005372 Heme NO binding; Region: HNOB; pfam07700 266835005373 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 266835005374 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 266835005375 Patatin phospholipase; Region: DUF3734; pfam12536 266835005376 acetoacetate decarboxylase; Provisional; Region: PRK02265 266835005377 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835005378 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 266835005379 NAD(P) binding site [chemical binding]; other site 266835005380 active site 266835005381 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 266835005382 HlyD family secretion protein; Region: HlyD_3; pfam13437 266835005383 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 266835005384 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 266835005385 nucleophile elbow; other site 266835005386 Uncharacterized conserved protein [Function unknown]; Region: COG2968 266835005387 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 266835005388 hypothetical protein; Provisional; Region: PRK05170 266835005389 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 266835005390 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 266835005391 ligand binding site [chemical binding]; other site 266835005392 short chain dehydrogenase; Provisional; Region: PRK08278 266835005393 human hydroxysteroid dehydrogenase-like protein 2 (HSDL2), classical (c) SDRs; Region: HSDL2_SDR_c; cd09762 266835005394 NAD(P) binding site [chemical binding]; other site 266835005395 homodimer interface [polypeptide binding]; other site 266835005396 active site 266835005397 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 266835005398 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266835005399 DNA binding residues [nucleotide binding] 266835005400 dimerization interface [polypeptide binding]; other site 266835005401 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 266835005402 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 266835005403 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 266835005404 protein binding site [polypeptide binding]; other site 266835005405 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 266835005406 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 266835005407 protein binding site [polypeptide binding]; other site 266835005408 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_22; cd08359 266835005409 putative dimer interface [polypeptide binding]; other site 266835005410 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266835005411 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266835005412 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266835005413 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266835005414 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266835005415 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266835005416 dimerization interface [polypeptide binding]; other site 266835005417 Acyl carrier protein phosphodiesterase [Lipid metabolism]; Region: AcpD; COG1182 266835005418 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 266835005419 Predicted transcriptional regulator [Transcription]; Region: COG3905 266835005420 Predicted membrane protein [Function unknown]; Region: COG4541 266835005421 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 266835005422 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 266835005423 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266835005424 putative DNA binding site [nucleotide binding]; other site 266835005425 putative Zn2+ binding site [ion binding]; other site 266835005426 AsnC family; Region: AsnC_trans_reg; pfam01037 266835005427 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266835005428 Major Facilitator Superfamily; Region: MFS_1; pfam07690 266835005429 putative substrate translocation pore; other site 266835005430 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 266835005431 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 266835005432 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 266835005433 dimer interface [polypeptide binding]; other site 266835005434 decamer (pentamer of dimers) interface [polypeptide binding]; other site 266835005435 catalytic triad [active] 266835005436 Bacterial transcriptional activator domain; Region: BTAD; smart01043 266835005437 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 266835005438 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266835005439 DNA-binding site [nucleotide binding]; DNA binding site 266835005440 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 266835005441 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266835005442 homodimer interface [polypeptide binding]; other site 266835005443 catalytic residue [active] 266835005444 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 266835005445 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 266835005446 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 266835005447 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312 266835005448 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 266835005449 putative ligand binding site [chemical binding]; other site 266835005450 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 266835005451 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 266835005452 TM-ABC transporter signature motif; other site 266835005453 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 266835005454 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 266835005455 Walker A/P-loop; other site 266835005456 ATP binding site [chemical binding]; other site 266835005457 Q-loop/lid; other site 266835005458 ABC transporter signature motif; other site 266835005459 Walker B; other site 266835005460 D-loop; other site 266835005461 H-loop/switch region; other site 266835005462 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 266835005463 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266835005464 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 266835005465 hydroxyglutarate oxidase; Provisional; Region: PRK11728 266835005466 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 266835005467 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 266835005468 Uncharacterized conserved protein [Function unknown]; Region: COG5453 266835005469 Cephalosporin hydroxylase [Defense mechanisms]; Region: CmcI; COG3510 266835005470 Macrocin-O-methyltransferase (TylF); Region: TylF; pfam05711 266835005471 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266835005472 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266835005473 WHG domain; Region: WHG; pfam13305 266835005474 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 266835005475 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4298 266835005476 Predicted transcriptional regulators [Transcription]; Region: COG1695 266835005477 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 266835005478 Predicted thiol-disulfide oxidoreductase [General function prediction only]; Region: COG3011 266835005479 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 266835005480 Domain of unknown function (DUF333); Region: DUF333; pfam03891 266835005481 Uncharacterized conserved protein [Function unknown]; Region: COG4274 266835005482 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 266835005483 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 266835005484 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 266835005485 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 266835005486 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 266835005487 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 266835005488 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 266835005489 DNA binding residues [nucleotide binding] 266835005490 DNA primase; Validated; Region: dnaG; PRK05667 266835005491 CHC2 zinc finger; Region: zf-CHC2; pfam01807 266835005492 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 266835005493 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 266835005494 active site 266835005495 metal binding site [ion binding]; metal-binding site 266835005496 interdomain interaction site; other site 266835005497 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 266835005498 Predicted integral membrane protein [Function unknown]; Region: COG5455 266835005499 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 266835005500 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 266835005501 PhoU domain; Region: PhoU; pfam01895 266835005502 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266835005503 Major Facilitator Superfamily; Region: MFS_1; pfam07690 266835005504 putative substrate translocation pore; other site 266835005505 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266835005506 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266835005507 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 266835005508 putative effector binding pocket; other site 266835005509 putative dimerization interface [polypeptide binding]; other site 266835005510 short chain dehydrogenase; Provisional; Region: PRK06482 266835005511 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 266835005512 NADP binding site [chemical binding]; other site 266835005513 active site 266835005514 steroid binding site; other site 266835005515 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 266835005516 zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033 266835005517 metal-binding site [ion binding] 266835005518 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 266835005519 Helix-Turn-Helix DNA binding domain of the CadR- and PbrR-like transcription regulators; Region: HTH_CadR-PbrR-like; cd04785 266835005520 DNA binding residues [nucleotide binding] 266835005521 Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047 266835005522 dimer interface [polypeptide binding]; other site 266835005523 putative metal binding site [ion binding]; other site 266835005524 L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253 266835005525 homodimer interface [polypeptide binding]; other site 266835005526 homotetramer interface [polypeptide binding]; other site 266835005527 active site pocket [active] 266835005528 cleavage site 266835005529 Predicted acetyltransferase [General function prediction only]; Region: COG3981 266835005530 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 266835005531 Coenzyme A binding pocket [chemical binding]; other site 266835005532 L,D-transpeptidase catalytic domain; Region: YkuD_2; pfam13645 266835005533 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 266835005534 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 266835005535 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266835005536 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266835005537 dimerization interface [polypeptide binding]; other site 266835005538 LysR substrate binding domain; Region: LysR_substrate; pfam03466 266835005539 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 266835005540 Predicted transcriptional regulators [Transcription]; Region: COG1695 266835005541 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 266835005542 Uncharacterized conserved protein [Function unknown]; Region: COG1610 266835005543 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 266835005544 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 266835005545 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 266835005546 catalytic site [active] 266835005547 subunit interface [polypeptide binding]; other site 266835005548 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 266835005549 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 266835005550 active site 266835005551 catalytic tetrad [active] 266835005552 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266835005553 Major Facilitator Superfamily; Region: MFS_1; pfam07690 266835005554 putative substrate translocation pore; other site 266835005555 Predicted metalloprotease [General function prediction only]; Region: COG2321 266835005556 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 266835005557 manganese transport regulator MntR; Provisional; Region: PRK11050 266835005558 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 266835005559 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 266835005560 manganese transport protein MntH; Reviewed; Region: PRK00701 266835005561 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 266835005562 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 266835005563 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266835005564 S-adenosylmethionine binding site [chemical binding]; other site 266835005565 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 266835005566 RibD C-terminal domain; Region: RibD_C; pfam01872 266835005567 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266835005568 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266835005569 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266835005570 dimerization interface [polypeptide binding]; other site 266835005571 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 266835005572 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 266835005573 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835005574 NAD(P) binding site [chemical binding]; other site 266835005575 active site 266835005576 Transcriptional regulators [Transcription]; Region: MarR; COG1846 266835005577 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 266835005578 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 266835005579 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266835005580 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266835005581 putative DNA binding site [nucleotide binding]; other site 266835005582 putative Zn2+ binding site [ion binding]; other site 266835005583 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 266835005584 nucleoside/Zn binding site; other site 266835005585 dimer interface [polypeptide binding]; other site 266835005586 catalytic motif [active] 266835005587 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 266835005588 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 266835005589 active site 266835005590 metal binding site [ion binding]; metal-binding site 266835005591 Bacterial SH3 domain; Region: SH3_3; pfam08239 266835005592 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 266835005593 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 266835005594 ATP-grasp domain; Region: ATP-grasp_4; cl17255 266835005595 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 266835005596 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 266835005597 ATP-grasp domain; Region: ATP-grasp_4; cl17255 266835005598 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 266835005599 IMP binding site; other site 266835005600 dimer interface [polypeptide binding]; other site 266835005601 interdomain contacts; other site 266835005602 partial ornithine binding site; other site 266835005603 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 266835005604 homotrimer interaction site [polypeptide binding]; other site 266835005605 putative active site [active] 266835005606 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 266835005607 homotrimer interaction site [polypeptide binding]; other site 266835005608 putative active site [active] 266835005609 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG3837 266835005610 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4312 266835005611 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 266835005612 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 266835005613 Coenzyme A binding pocket [chemical binding]; other site 266835005614 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 266835005615 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 266835005616 N-acetyl-D-glucosamine binding site [chemical binding]; other site 266835005617 catalytic residue [active] 266835005618 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 266835005619 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 266835005620 DNA binding site [nucleotide binding] 266835005621 active site 266835005622 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 266835005623 DNA-binding site [nucleotide binding]; DNA binding site 266835005624 RNA-binding motif; other site 266835005625 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 266835005626 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266835005627 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266835005628 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 266835005629 putative effector binding pocket; other site 266835005630 putative dimerization interface [polypeptide binding]; other site 266835005631 SnoaL-like domain; Region: SnoaL_2; pfam12680 266835005632 short chain dehydrogenase; Provisional; Region: PRK06523 266835005633 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835005634 NAD(P) binding site [chemical binding]; other site 266835005635 active site 266835005636 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 266835005637 GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056 266835005638 putative C-terminal domain interface [polypeptide binding]; other site 266835005639 putative GSH binding site (G-site) [chemical binding]; other site 266835005640 putative dimer interface [polypeptide binding]; other site 266835005641 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 266835005642 N-terminal domain interface [polypeptide binding]; other site 266835005643 dimer interface [polypeptide binding]; other site 266835005644 substrate binding pocket (H-site) [chemical binding]; other site 266835005645 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 266835005646 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 266835005647 aspartate aminotransferase; Provisional; Region: PRK05764 266835005648 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 266835005649 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266835005650 homodimer interface [polypeptide binding]; other site 266835005651 catalytic residue [active] 266835005652 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266835005653 Major Facilitator Superfamily; Region: MFS_1; pfam07690 266835005654 putative substrate translocation pore; other site 266835005655 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266835005656 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266835005657 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266835005658 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 266835005659 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 266835005660 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266835005661 metal binding site [ion binding]; metal-binding site 266835005662 active site 266835005663 I-site; other site 266835005664 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 266835005665 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 266835005666 elongation factor G; Reviewed; Region: PRK12740 266835005667 G1 box; other site 266835005668 putative GEF interaction site [polypeptide binding]; other site 266835005669 GTP/Mg2+ binding site [chemical binding]; other site 266835005670 Switch I region; other site 266835005671 G2 box; other site 266835005672 G3 box; other site 266835005673 Switch II region; other site 266835005674 G4 box; other site 266835005675 G5 box; other site 266835005676 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 266835005677 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 266835005678 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 266835005679 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 266835005680 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266835005681 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266835005682 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 266835005683 putative effector binding pocket; other site 266835005684 dimerization interface [polypeptide binding]; other site 266835005685 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 266835005686 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 266835005687 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 266835005688 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 266835005689 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266835005690 putative DNA binding site [nucleotide binding]; other site 266835005691 putative Zn2+ binding site [ion binding]; other site 266835005692 AsnC family; Region: AsnC_trans_reg; pfam01037 266835005693 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 266835005694 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 266835005695 putative metal binding site; other site 266835005696 histidinol-phosphate phosphatase family domain; Region: Histidinol-ppas; TIGR01656 266835005697 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 266835005698 active site 266835005699 motif I; other site 266835005700 motif II; other site 266835005701 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 266835005702 dimer interface [polypeptide binding]; other site 266835005703 active site 266835005704 ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870 266835005705 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 266835005706 putative ribose interaction site [chemical binding]; other site 266835005707 putative ADP binding site [chemical binding]; other site 266835005708 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 266835005709 active site 266835005710 nucleotide binding site [chemical binding]; other site 266835005711 HIGH motif; other site 266835005712 KMSKS motif; other site 266835005713 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 266835005714 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 266835005715 ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197 266835005716 NADP binding site [chemical binding]; other site 266835005717 homopentamer interface [polypeptide binding]; other site 266835005718 substrate binding site [chemical binding]; other site 266835005719 active site 266835005720 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 266835005721 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 266835005722 putative active site [active] 266835005723 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 266835005724 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 266835005725 putative active site [active] 266835005726 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 266835005727 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 266835005728 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 266835005729 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266835005730 binding surface 266835005731 Tetratricopeptide repeat; Region: TPR_16; pfam13432 266835005732 TPR motif; other site 266835005733 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3921 266835005734 Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904 266835005735 LssY C-terminus; Region: LssY_C; pfam14067 266835005736 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 266835005737 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276 266835005738 putative NAD(P) binding site [chemical binding]; other site 266835005739 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266835005740 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266835005741 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_6; cd08475 266835005742 putative effector binding pocket; other site 266835005743 putative dimerization interface [polypeptide binding]; other site 266835005744 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 266835005745 Domain of unknown function DUF21; Region: DUF21; pfam01595 266835005746 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 266835005747 Transporter associated domain; Region: CorC_HlyC; smart01091 266835005748 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 266835005749 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 266835005750 HlyD family secretion protein; Region: HlyD_3; pfam13437 266835005751 ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618 266835005752 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 266835005753 ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246 266835005754 Walker A/P-loop; other site 266835005755 ATP binding site [chemical binding]; other site 266835005756 Q-loop/lid; other site 266835005757 ABC transporter signature motif; other site 266835005758 Walker B; other site 266835005759 D-loop; other site 266835005760 H-loop/switch region; other site 266835005761 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 266835005762 Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273 266835005763 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 266835005764 active site 266835005765 catalytic residues [active] 266835005766 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 266835005767 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 266835005768 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 266835005769 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 266835005770 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266835005771 putative substrate translocation pore; other site 266835005772 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 266835005773 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 266835005774 HlyD family secretion protein; Region: HlyD_3; pfam13437 266835005775 Predicted transcriptional regulators [Transcription]; Region: COG1733 266835005776 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 266835005777 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 266835005778 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 266835005779 NAD(P) binding site [chemical binding]; other site 266835005780 Predicted transcriptional regulators [Transcription]; Region: COG1733 266835005781 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 266835005782 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 266835005783 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 266835005784 Subgroup of sulfite oxidase (SO) family molybdopterin binding domains that contains conserved dimerization domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate...; Region: SO_family_Moco_dimer; cd02110 266835005785 Moco binding site; other site 266835005786 metal coordination site [ion binding]; other site 266835005787 dimerization interface [polypeptide binding]; other site 266835005788 Predicted flavoprotein [General function prediction only]; Region: COG0431 266835005789 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 266835005790 Predicted transcriptional regulators [Transcription]; Region: COG1733 266835005791 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 266835005792 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 266835005793 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 266835005794 ATP binding site [chemical binding]; other site 266835005795 active site 266835005796 substrate binding site [chemical binding]; other site 266835005797 choline dehydrogenase; Validated; Region: PRK02106 266835005798 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 266835005799 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 266835005800 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 266835005801 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 266835005802 active site pocket [active] 266835005803 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 266835005804 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 266835005805 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 266835005806 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 266835005807 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 266835005808 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 266835005809 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 266835005810 FAD binding domain; Region: FAD_binding_4; pfam01565 266835005811 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 266835005812 Protein of unknown function (DUF1344); Region: DUF1344; pfam07076 266835005813 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3779 266835005814 Uncharacterized protein conserved in bacteria (DUF2314); Region: DUF2314; pfam10077 266835005815 Protein of unknown function (DUF3137); Region: DUF3137; pfam11335 266835005816 Putative enzyme of poly-gamma-glutamate biosynthesis (capsule formation) [Cell envelope biogenesis, outer membrane]; Region: PgsA; COG2843 266835005817 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 266835005818 putative active site [active] 266835005819 putative metal binding site [ion binding]; other site 266835005820 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 266835005821 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 266835005822 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266835005823 S-adenosylmethionine binding site [chemical binding]; other site 266835005824 Protein of unknown function (DUF2778); Region: DUF2778; pfam10908 266835005825 excinuclease ABC subunit B; Provisional; Region: PRK05298 266835005826 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 266835005827 ATP binding site [chemical binding]; other site 266835005828 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 266835005829 nucleotide binding region [chemical binding]; other site 266835005830 ATP-binding site [chemical binding]; other site 266835005831 Ultra-violet resistance protein B; Region: UvrB; pfam12344 266835005832 UvrB/uvrC motif; Region: UVR; pfam02151 266835005833 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 266835005834 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 266835005835 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 266835005836 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 266835005837 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 266835005838 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 266835005839 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 266835005840 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 266835005841 putative C-terminal domain interface [polypeptide binding]; other site 266835005842 putative GSH binding site (G-site) [chemical binding]; other site 266835005843 putative dimer interface [polypeptide binding]; other site 266835005844 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 266835005845 dimer interface [polypeptide binding]; other site 266835005846 N-terminal domain interface [polypeptide binding]; other site 266835005847 putative substrate binding pocket (H-site) [chemical binding]; other site 266835005848 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 266835005849 putative dimer interface [polypeptide binding]; other site 266835005850 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266835005851 Uncharacterized conserved protein [Function unknown]; Region: COG5507 266835005852 RibD C-terminal domain; Region: RibD_C; pfam01872 266835005853 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 266835005854 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266835005855 TPR motif; other site 266835005856 binding surface 266835005857 Tetratricopeptide repeat; Region: TPR_12; pfam13424 266835005858 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266835005859 binding surface 266835005860 TPR motif; other site 266835005861 Tetratricopeptide repeat; Region: TPR_12; pfam13424 266835005862 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266835005863 binding surface 266835005864 TPR motif; other site 266835005865 Sulfotransferase family; Region: Sulfotransfer_3; pfam13469 266835005866 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 266835005867 DNA-binding site [nucleotide binding]; DNA binding site 266835005868 RNA-binding motif; other site 266835005869 Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the...; Region: KAZAL_FS; cl00097 266835005870 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 266835005871 DNA-binding site [nucleotide binding]; DNA binding site 266835005872 RNA-binding motif; other site 266835005873 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 266835005874 DNA-binding site [nucleotide binding]; DNA binding site 266835005875 RNA-binding motif; other site 266835005876 BA14K-like protein; Region: BA14K; pfam07886 266835005877 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 266835005878 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 266835005879 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 266835005880 homodimer interface [polypeptide binding]; other site 266835005881 substrate-cofactor binding pocket; other site 266835005882 catalytic residue [active] 266835005883 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 266835005884 MarR family; Region: MarR_2; pfam12802 266835005885 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 266835005886 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266835005887 active site 266835005888 phosphorylation site [posttranslational modification] 266835005889 intermolecular recognition site; other site 266835005890 dimerization interface [polypeptide binding]; other site 266835005891 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266835005892 DNA binding site [nucleotide binding] 266835005893 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 266835005894 HAMP domain; Region: HAMP; pfam00672 266835005895 His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388 266835005896 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266835005897 ATP binding site [chemical binding]; other site 266835005898 Mg2+ binding site [ion binding]; other site 266835005899 G-X-G motif; other site 266835005900 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 266835005901 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 266835005902 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 266835005903 dimer interface [polypeptide binding]; other site 266835005904 putative tRNA-binding site [nucleotide binding]; other site 266835005905 Uncharacterized conserved protein [Function unknown]; Region: COG5465 266835005906 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2960 266835005907 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3514 266835005908 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 266835005909 Uncharacterized conserved protein [Function unknown]; Region: COG1565 266835005910 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 266835005911 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 266835005912 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 266835005913 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 266835005914 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 266835005915 active site 266835005916 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 266835005917 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 266835005918 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 266835005919 active site 266835005920 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 266835005921 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 266835005922 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266835005923 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266835005924 Major Facilitator Superfamily; Region: MFS_1; pfam07690 266835005925 putative substrate translocation pore; other site 266835005926 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 266835005927 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 266835005928 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 266835005929 Transcriptional regulators [Transcription]; Region: MarR; COG1846 266835005930 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266835005931 putative Zn2+ binding site [ion binding]; other site 266835005932 putative DNA binding site [nucleotide binding]; other site 266835005933 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 266835005934 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 266835005935 5S rRNA interface [nucleotide binding]; other site 266835005936 CTC domain interface [polypeptide binding]; other site 266835005937 L16 interface [polypeptide binding]; other site 266835005938 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 266835005939 putative active site [active] 266835005940 catalytic residue [active] 266835005941 GTP-binding protein YchF; Reviewed; Region: PRK09601 266835005942 YchF GTPase; Region: YchF; cd01900 266835005943 G1 box; other site 266835005944 GTP/Mg2+ binding site [chemical binding]; other site 266835005945 Switch I region; other site 266835005946 G2 box; other site 266835005947 Switch II region; other site 266835005948 G3 box; other site 266835005949 G4 box; other site 266835005950 G5 box; other site 266835005951 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 266835005952 Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin...; Region: APH; cd05150 266835005953 active site 266835005954 ATP binding site [chemical binding]; other site 266835005955 Phosphotransferase enzyme family; Region: APH; pfam01636 266835005956 antibiotic binding site [chemical binding]; other site 266835005957 uncharacterized subgroup of the Escherichia coli Mg2+ transporter CorA_like subfamily; Region: EcCorA-like_u1; cd12837 266835005958 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 266835005959 oligomer interface [polypeptide binding]; other site 266835005960 Cl binding site [ion binding]; other site 266835005961 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 266835005962 putative active site [active] 266835005963 putative catalytic site [active] 266835005964 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 266835005965 putative active site [active] 266835005966 putative catalytic site [active] 266835005967 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 266835005968 active site 266835005969 Putative lumazine-binding; Region: Lumazine_bd_2; pfam12893 266835005970 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 266835005971 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 266835005972 phosphate binding site [ion binding]; other site 266835005973 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 266835005974 PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397 266835005975 active site 266835005976 Cytochrome C1 family; Region: Cytochrom_C1; pfam02167 266835005977 cytochrome b; Provisional; Region: CYTB; MTH00119 266835005978 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 266835005979 Qi binding site; other site 266835005980 intrachain domain interface; other site 266835005981 interchain domain interface [polypeptide binding]; other site 266835005982 heme bH binding site [chemical binding]; other site 266835005983 heme bL binding site [chemical binding]; other site 266835005984 Qo binding site; other site 266835005985 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290 266835005986 interchain domain interface [polypeptide binding]; other site 266835005987 intrachain domain interface; other site 266835005988 Qi binding site; other site 266835005989 Qo binding site; other site 266835005990 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399 266835005991 ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416 266835005992 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 266835005993 [2Fe-2S] cluster binding site [ion binding]; other site 266835005994 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 266835005995 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 266835005996 Epoxide hydrolase N terminus; Region: EHN; pfam06441 266835005997 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 266835005998 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 266835005999 Coenzyme A binding pocket [chemical binding]; other site 266835006000 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 266835006001 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 266835006002 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266835006003 Walker A/P-loop; other site 266835006004 ATP binding site [chemical binding]; other site 266835006005 Q-loop/lid; other site 266835006006 ABC transporter signature motif; other site 266835006007 Walker B; other site 266835006008 D-loop; other site 266835006009 H-loop/switch region; other site 266835006010 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 266835006011 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 266835006012 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 266835006013 Walker A/P-loop; other site 266835006014 ATP binding site [chemical binding]; other site 266835006015 Q-loop/lid; other site 266835006016 ABC transporter signature motif; other site 266835006017 Walker B; other site 266835006018 D-loop; other site 266835006019 H-loop/switch region; other site 266835006020 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 266835006021 redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950 266835006022 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 266835006023 DNA binding residues [nucleotide binding] 266835006024 dimer interface [polypeptide binding]; other site 266835006025 [2Fe-2S] cluster binding site [ion binding]; other site 266835006026 Coproporphyrinogen III oxidase [Coenzyme metabolism]; Region: HemF; COG0408 266835006027 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; cl17752 266835006028 Predicted small metal-binding protein [Function unknown]; Region: COG5466 266835006029 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 266835006030 active site 266835006031 catalytic residues [active] 266835006032 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 266835006033 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 266835006034 active site 266835006035 NTP binding site [chemical binding]; other site 266835006036 metal binding triad [ion binding]; metal-binding site 266835006037 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 266835006038 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 266835006039 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 266835006040 putative active site [active] 266835006041 putative CoA binding site [chemical binding]; other site 266835006042 nudix motif; other site 266835006043 metal binding site [ion binding]; metal-binding site 266835006044 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3816 266835006045 Protein of unknown function (DUF1285); Region: DUF1285; pfam06938 266835006046 MoxR-like ATPases [General function prediction only]; Region: COG0714 266835006047 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 266835006048 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 266835006049 Protein of unknown function DUF58; Region: DUF58; pfam01882 266835006050 N-terminal double-transmembrane domain; Region: two_anch; TIGR02226 266835006051 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 266835006052 Domain of unknown function (DUF4159); Region: DUF4159; pfam13709 266835006053 Protein of unknown function (DUF1355); Region: DUF1355; cl17712 266835006054 ATP-dependent Clp protease adaptor; Reviewed; Region: clpS; PRK13019 266835006055 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 266835006056 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266835006057 active site 266835006058 phosphorylation site [posttranslational modification] 266835006059 intermolecular recognition site; other site 266835006060 dimerization interface [polypeptide binding]; other site 266835006061 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266835006062 DNA binding site [nucleotide binding] 266835006063 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 266835006064 dimerization interface [polypeptide binding]; other site 266835006065 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266835006066 ATP binding site [chemical binding]; other site 266835006067 Mg2+ binding site [ion binding]; other site 266835006068 G-X-G motif; other site 266835006069 choline ABC transporter, ATP-binding protein; Region: ABC_choXWV_ATP; TIGR03415 266835006070 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266835006071 Walker A/P-loop; other site 266835006072 ATP binding site [chemical binding]; other site 266835006073 Q-loop/lid; other site 266835006074 ABC transporter signature motif; other site 266835006075 Walker B; other site 266835006076 D-loop; other site 266835006077 H-loop/switch region; other site 266835006078 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835006079 dimer interface [polypeptide binding]; other site 266835006080 conserved gate region; other site 266835006081 putative PBP binding loops; other site 266835006082 ABC-ATPase subunit interface; other site 266835006083 choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414 266835006084 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 266835006085 Thymidine kinase [Nucleotide transport and metabolism]; Region: Tdk; COG1435 266835006086 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 266835006087 EamA-like transporter family; Region: EamA; pfam00892 266835006088 EamA-like transporter family; Region: EamA; pfam00892 266835006089 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266835006090 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266835006091 dimerization interface [polypeptide binding]; other site 266835006092 Cytochrome c2 [Energy production and conversion]; Region: COG3474 266835006093 hypothetical protein; Validated; Region: PRK09039 266835006094 Fic family protein [Function unknown]; Region: COG3177 266835006095 Fic/DOC family; Region: Fic; pfam02661 266835006096 ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464 266835006097 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 266835006098 Walker A motif; other site 266835006099 ATP binding site [chemical binding]; other site 266835006100 Walker B motif; other site 266835006101 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5345 266835006102 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 266835006103 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 266835006104 Potassium binding sites [ion binding]; other site 266835006105 Cesium cation binding sites [ion binding]; other site 266835006106 Isochorismatase family; Region: Isochorismatase; pfam00857 266835006107 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 266835006108 catalytic triad [active] 266835006109 conserved cis-peptide bond; other site 266835006110 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 266835006111 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 266835006112 conserved cys residue [active] 266835006113 maltose O-acetyltransferase; Provisional; Region: PRK10092 266835006114 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 266835006115 active site 266835006116 substrate binding site [chemical binding]; other site 266835006117 trimer interface [polypeptide binding]; other site 266835006118 CoA binding site [chemical binding]; other site 266835006119 Predicted membrane protein [Function unknown]; Region: COG3918 266835006120 mercuric reductase; Validated; Region: PRK06370 266835006121 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 266835006122 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 266835006123 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 266835006124 MFS transport protein AraJ; Provisional; Region: PRK10091 266835006125 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266835006126 putative substrate translocation pore; other site 266835006127 Predicted deacylase [General function prediction only]; Region: COG3608 266835006128 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like subfamily; subgroup includes Pseudomonas aeruginosa AotO; Region: M14_PaAOTO_like; cd06250 266835006129 active site 266835006130 Zn binding site [ion binding]; other site 266835006131 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 266835006132 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 266835006133 tetramer interface [polypeptide binding]; other site 266835006134 active site 266835006135 Mg2+/Mn2+ binding site [ion binding]; other site 266835006136 anthranilate synthase; Provisional; Region: PRK13566 266835006137 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 266835006138 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 266835006139 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 266835006140 glutamine binding [chemical binding]; other site 266835006141 catalytic triad [active] 266835006142 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 266835006143 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 266835006144 Uncharacterized conserved protein [Function unknown]; Region: COG1416 266835006145 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 266835006146 classical (c) SDRs; Region: SDR_c; cd05233 266835006147 NAD(P) binding site [chemical binding]; other site 266835006148 active site 266835006149 Uncharacterized conserved protein [Function unknown]; Region: COG1359 266835006150 Putative ammonia monooxygenase; Region: AmoA; pfam05145 266835006151 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 266835006152 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 266835006153 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266835006154 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266835006155 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_7; cd08476 266835006156 putative effector binding pocket; other site 266835006157 putative dimerization interface [polypeptide binding]; other site 266835006158 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266835006159 putative substrate translocation pore; other site 266835006160 SnoaL-like domain; Region: SnoaL_2; pfam12680 266835006161 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947 266835006162 Putative esterase; Region: Esterase; pfam00756 266835006163 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 266835006164 2-isopropylmalate synthase; Validated; Region: PRK03739 266835006165 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 266835006166 active site 266835006167 catalytic residues [active] 266835006168 metal binding site [ion binding]; metal-binding site 266835006169 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 266835006170 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 266835006171 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266835006172 TPR motif; other site 266835006173 binding surface 266835006174 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 266835006175 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 266835006176 catalytic site [active] 266835006177 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 266835006178 Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400 266835006179 putative active site [active] 266835006180 putative metal binding site [ion binding]; other site 266835006181 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 266835006182 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_21; cd04680 266835006183 nudix motif; other site 266835006184 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 266835006185 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 266835006186 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 266835006187 putative dimer interface [polypeptide binding]; other site 266835006188 N-terminal domain interface [polypeptide binding]; other site 266835006189 putative substrate binding pocket (H-site) [chemical binding]; other site 266835006190 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 266835006191 Coenzyme A binding pocket [chemical binding]; other site 266835006192 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 266835006193 17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371 266835006194 NAD binding site [chemical binding]; other site 266835006195 homodimer interface [polypeptide binding]; other site 266835006196 homotetramer interface [polypeptide binding]; other site 266835006197 active site 266835006198 Putative heme iron utilization protein [Inorganic ion transport and metabolism]; Region: HugZ; COG0748 266835006199 Pyridoxamine 5'-phosphate oxidase; Region: Pyrid_oxidase_2; pfam13883 266835006200 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 266835006201 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266835006202 dimerization interface [polypeptide binding]; other site 266835006203 putative DNA binding site [nucleotide binding]; other site 266835006204 putative Zn2+ binding site [ion binding]; other site 266835006205 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 266835006206 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 266835006207 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 266835006208 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5400 266835006209 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5385 266835006210 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266835006211 Response regulator receiver domain; Region: Response_reg; pfam00072 266835006212 active site 266835006213 phosphorylation site [posttranslational modification] 266835006214 intermolecular recognition site; other site 266835006215 dimerization interface [polypeptide binding]; other site 266835006216 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 266835006217 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266835006218 active site 266835006219 phosphorylation site [posttranslational modification] 266835006220 intermolecular recognition site; other site 266835006221 dimerization interface [polypeptide binding]; other site 266835006222 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266835006223 DNA binding site [nucleotide binding] 266835006224 Predicted transcriptional regulators [Transcription]; Region: COG1733 266835006225 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266835006226 dimerization interface [polypeptide binding]; other site 266835006227 putative DNA binding site [nucleotide binding]; other site 266835006228 putative Zn2+ binding site [ion binding]; other site 266835006229 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 266835006230 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 266835006231 putative NAD(P) binding site [chemical binding]; other site 266835006232 Protein of unknown function (DUF1153); Region: DUF1153; pfam06627 266835006233 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 266835006234 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 266835006235 Ligand Binding Site [chemical binding]; other site 266835006236 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 266835006237 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 266835006238 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 266835006239 Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845 266835006240 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 266835006241 HlyD family secretion protein; Region: HlyD_3; pfam13437 266835006242 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266835006243 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266835006244 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06333 266835006245 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 266835006246 dimer interface [polypeptide binding]; other site 266835006247 active site 266835006248 short chain dehydrogenase; Provisional; Region: PRK06179 266835006249 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 266835006250 NADP binding site [chemical binding]; other site 266835006251 active site 266835006252 steroid binding site; other site 266835006253 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 266835006254 cyclase homology domain; Region: CHD; cd07302 266835006255 AAA ATPase domain; Region: AAA_16; pfam13191 266835006256 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 266835006257 structural tetrad; other site 266835006258 FOG: WD40 repeat [General function prediction only]; Region: COG2319 266835006259 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 266835006260 structural tetrad; other site 266835006261 FOG: WD40 repeat [General function prediction only]; Region: COG2319 266835006262 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 266835006263 metal ion-dependent adhesion site (MIDAS); other site 266835006264 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 266835006265 putative catalytic residues [active] 266835006266 Invasion protein B, involved in pathogenesis [General function prediction only]; Region: COG5342 266835006267 Domain of unknown function (DUF4189); Region: DUF4189; pfam13827 266835006268 Invasion associated locus B (IalB) protein; Region: IalB; pfam06776 266835006269 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 266835006270 trimer interface [polypeptide binding]; other site 266835006271 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 266835006272 trimer interface [polypeptide binding]; other site 266835006273 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 266835006274 trimer interface [polypeptide binding]; other site 266835006275 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 266835006276 trimer interface [polypeptide binding]; other site 266835006277 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 266835006278 trimer interface [polypeptide binding]; other site 266835006279 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 266835006280 trimer interface [polypeptide binding]; other site 266835006281 Autotransporter adhesin [Intracellular trafficking and secretion / Extracellular structures]; Region: Hia; COG5295 266835006282 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 266835006283 trimer interface [polypeptide binding]; other site 266835006284 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266835006285 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 266835006286 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266835006287 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 266835006288 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266835006289 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 266835006290 Putative catalytic domain, repeat 1, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar2_1; cd09157 266835006291 putative active site [active] 266835006292 catalytic site [active] 266835006293 Putative catalytic domain, repeat 2, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar2_2; cd09163 266835006294 putative active site [active] 266835006295 catalytic site [active] 266835006296 Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568 266835006297 putative catalytic site [active] 266835006298 putative metal binding site [ion binding]; other site 266835006299 putative catalytic site [active] 266835006300 putative phosphate binding site [ion binding]; other site 266835006301 putative phosphate binding site [ion binding]; other site 266835006302 putative metal binding site [ion binding]; other site 266835006303 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 266835006304 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266835006305 active site 266835006306 phosphorylation site [posttranslational modification] 266835006307 intermolecular recognition site; other site 266835006308 ANTAR domain; Region: ANTAR; pfam03861 266835006309 NMT1-like family; Region: NMT1_2; pfam13379 266835006310 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 266835006311 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 266835006312 NMT1-like family; Region: NMT1_2; pfam13379 266835006313 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 266835006314 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835006315 putative PBP binding loops; other site 266835006316 dimer interface [polypeptide binding]; other site 266835006317 ABC-ATPase subunit interface; other site 266835006318 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 266835006319 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 266835006320 Walker A/P-loop; other site 266835006321 ATP binding site [chemical binding]; other site 266835006322 Q-loop/lid; other site 266835006323 ABC transporter signature motif; other site 266835006324 Walker B; other site 266835006325 D-loop; other site 266835006326 H-loop/switch region; other site 266835006327 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 266835006328 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 266835006329 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 266835006330 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 266835006331 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 266835006332 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 266835006333 [2Fe-2S] cluster binding site [ion binding]; other site 266835006334 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 266835006335 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 266835006336 [4Fe-4S] binding site [ion binding]; other site 266835006337 molybdopterin cofactor binding site; other site 266835006338 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 266835006339 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 266835006340 molybdopterin cofactor binding site; other site 266835006341 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 266835006342 aldehyde dehydrogenase family 7 member; Region: PLN02315 266835006343 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 266835006344 tetrameric interface [polypeptide binding]; other site 266835006345 NAD binding site [chemical binding]; other site 266835006346 catalytic residues [active] 266835006347 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 266835006348 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 266835006349 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 266835006350 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 266835006351 Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569 266835006352 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 266835006353 Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569 266835006354 Eukaryotic DNA topoisomerase I, catalytic core; Region: Topoisom_I; pfam01028 266835006355 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 266835006356 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 266835006357 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 266835006358 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 266835006359 Uncharacterized conserved protein [Function unknown]; Region: COG2308 266835006360 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 266835006361 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 266835006362 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 266835006363 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 266835006364 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 266835006365 Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899 266835006366 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4196 266835006367 Glutaryl-CoA dehydrogenase; Region: GCD; cd01151 266835006368 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 266835006369 FAD binding site [chemical binding]; other site 266835006370 substrate binding pocket [chemical binding]; other site 266835006371 catalytic base [active] 266835006372 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 266835006373 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266835006374 The C-terminal substrate binding domain of LysR-type transcriptional regulators GcdR-like, contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_like; cd08481 266835006375 dimerization interface [polypeptide binding]; other site 266835006376 substrate binding pocket [chemical binding]; other site 266835006377 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 266835006378 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 266835006379 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 266835006380 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 266835006381 RNA binding site [nucleotide binding]; other site 266835006382 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 266835006383 Beta-lactamase; Region: Beta-lactamase; pfam00144 266835006384 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 266835006385 Beta-lactamase; Region: Beta-lactamase; pfam00144 266835006386 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 266835006387 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 266835006388 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 266835006389 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835006390 dimer interface [polypeptide binding]; other site 266835006391 conserved gate region; other site 266835006392 putative PBP binding loops; other site 266835006393 ABC-ATPase subunit interface; other site 266835006394 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835006395 dimer interface [polypeptide binding]; other site 266835006396 conserved gate region; other site 266835006397 putative PBP binding loops; other site 266835006398 ABC-ATPase subunit interface; other site 266835006399 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 266835006400 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 266835006401 Walker A/P-loop; other site 266835006402 ATP binding site [chemical binding]; other site 266835006403 Q-loop/lid; other site 266835006404 ABC transporter signature motif; other site 266835006405 Walker B; other site 266835006406 D-loop; other site 266835006407 H-loop/switch region; other site 266835006408 TOBE domain; Region: TOBE_2; pfam08402 266835006409 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 266835006410 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 266835006411 active site 266835006412 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266835006413 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266835006414 Histone deacetylase class IIa; Region: HDAC_classII_APAH; cd10001 266835006415 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 266835006416 active site 266835006417 Zn binding site [ion binding]; other site 266835006418 Protein of unknown function (DUF1625); Region: DUF1625; pfam07787 266835006419 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266835006420 DNA binding residues [nucleotide binding] 266835006421 dimerization interface [polypeptide binding]; other site 266835006422 LuxR family transcriptional regulatory, chaperone HchA-associated; Region: reg_near_HchA; TIGR03541 266835006423 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266835006424 DNA binding residues [nucleotide binding] 266835006425 dimerization interface [polypeptide binding]; other site 266835006426 Flagellar biosynthesis pathway, component FlhB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhB; COG1377 266835006427 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 266835006428 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 266835006429 FliG C-terminal domain; Region: FliG_C; pfam01706 266835006430 flagellar motor switch protein FliN; Region: fliN; TIGR02480 266835006431 Flagellar motor switch protein [Cell motility and secretion]; Region: FliM; COG1868 266835006432 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 266835006433 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 266835006434 flagellar motor protein MotA; Validated; Region: PRK09110 266835006435 Protein of unknown function (DUF1217); Region: DUF1217; pfam06748 266835006436 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12642 266835006437 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 266835006438 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 266835006439 flagellum-specific ATP synthase; Validated; Region: fliI; PRK06002 266835006440 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 266835006441 Walker A motif; other site 266835006442 ATP binding site [chemical binding]; other site 266835006443 Walker B motif; other site 266835006444 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK06003 266835006445 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 266835006446 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK12782 266835006447 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 266835006448 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00790 266835006449 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12691 266835006450 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 266835006451 Flagellar basal body P-ring biosynthesis protein [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FlgA; COG1261 266835006452 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 266835006453 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 266835006454 Flagellar basal-body P-ring protein [Cell motility and secretion]; Region: FlgI; COG1706 266835006455 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 266835006456 Uncharacterized conserved protein [Function unknown]; Region: COG3334 266835006457 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 266835006458 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 266835006459 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 266835006460 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 266835006461 flagellin; Reviewed; Region: PRK12687 266835006462 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 266835006463 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 266835006464 flagellin; Reviewed; Region: PRK12687 266835006465 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 266835006466 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 266835006467 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 266835006468 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 266835006469 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 266835006470 flagellar motor protein MotB; Validated; Region: motB; PRK05996 266835006471 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 266835006472 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 266835006473 ligand binding site [chemical binding]; other site 266835006474 chemotaxis protein; Reviewed; Region: PRK12798 266835006475 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 266835006476 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 266835006477 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 266835006478 N-acetyl-D-glucosamine binding site [chemical binding]; other site 266835006479 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 266835006480 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 266835006481 active site 266835006482 dimerization interface [polypeptide binding]; other site 266835006483 DNA binding site [nucleotide binding] 266835006484 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 266835006485 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 266835006486 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 266835006487 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 266835006488 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 266835006489 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07521 266835006490 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 266835006491 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK06008 266835006492 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 266835006493 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 266835006494 Flagellar biosynthesis regulator FlaF [Cell motility and secretion]; Region: FlaF; COG5442 266835006495 flagellar biosynthesis regulatory protein FlaF; Reviewed; Region: flaF; PRK12793 266835006496 Flagellar biosynthesis regulator FlbT [Cell motility and secretion]; Region: FlbT; COG5443 266835006497 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06009 266835006498 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 266835006499 flagellar biosynthesis protein FliQ; Reviewed; Region: fliQ; PRK06010 266835006500 Transmembrane secretion effector; Region: MFS_3; pfam05977 266835006501 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266835006502 putative substrate translocation pore; other site 266835006503 Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450 266835006504 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 266835006505 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 266835006506 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 266835006507 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 266835006508 Walker A/P-loop; other site 266835006509 ATP binding site [chemical binding]; other site 266835006510 Q-loop/lid; other site 266835006511 ABC transporter signature motif; other site 266835006512 Walker B; other site 266835006513 D-loop; other site 266835006514 H-loop/switch region; other site 266835006515 TOBE domain; Region: TOBE_2; pfam08402 266835006516 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 266835006517 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835006518 dimer interface [polypeptide binding]; other site 266835006519 conserved gate region; other site 266835006520 putative PBP binding loops; other site 266835006521 ABC-ATPase subunit interface; other site 266835006522 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 266835006523 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835006524 dimer interface [polypeptide binding]; other site 266835006525 conserved gate region; other site 266835006526 putative PBP binding loops; other site 266835006527 ABC-ATPase subunit interface; other site 266835006528 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 266835006529 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 266835006530 Helix-turn-helix domain; Region: HTH_19; pfam12844 266835006531 sequence-specific DNA binding site [nucleotide binding]; other site 266835006532 salt bridge; other site 266835006533 Cupin domain; Region: Cupin_2; pfam07883 266835006534 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 266835006535 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 266835006536 Cl- selectivity filter; other site 266835006537 Cl- binding residues [ion binding]; other site 266835006538 pore gating glutamate residue; other site 266835006539 dimer interface [polypeptide binding]; other site 266835006540 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the metalloprotease peptidase M50. CBS is a small domain originally identified in cystathionine beta-synthase and subsequently found in a wide...; Region: CBS_pair_M50_like; cd04801 266835006541 Uncharacterized conserved protein [Function unknown]; Region: COG1359 266835006542 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980 266835006543 FHIPEP family; Region: FHIPEP; pfam00771 266835006544 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 266835006545 Methyltransferase domain; Region: Methyltransf_23; pfam13489 266835006546 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266835006547 S-adenosylmethionine binding site [chemical binding]; other site 266835006548 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 266835006549 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 266835006550 Predicted aminopeptidase [General function prediction only]; Region: COG4324 266835006551 Rod binding protein; Region: Rod-binding; pfam10135 266835006552 Putative sterol carrier protein [Lipid metabolism]; Region: COG3255 266835006553 Predicted acetyltransferase [General function prediction only]; Region: COG3153 266835006554 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 266835006555 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622 266835006556 active site 266835006557 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 266835006558 dimer interface [polypeptide binding]; other site 266835006559 catalytic residues [active] 266835006560 substrate binding site [chemical binding]; other site 266835006561 amidase; Provisional; Region: PRK08310 266835006562 indole-3-acetamide amidohydrolase; Region: PLN02722 266835006563 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266835006564 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266835006565 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 266835006566 putative effector binding pocket; other site 266835006567 dimerization interface [polypeptide binding]; other site 266835006568 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG3683 266835006569 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG2215 266835006570 High-affinity nickel-transport protein; Region: NicO; cl00964 266835006571 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 266835006572 Escherichia coli Gne (a nucleoside-diphosphate-sugar 4-epimerase)-like, extended (e) SDRs; Region: Gne_like_SDR_e; cd05238 266835006573 putative NAD(P) binding site [chemical binding]; other site 266835006574 active site 266835006575 putative substrate binding site [chemical binding]; other site 266835006576 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 266835006577 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 266835006578 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 266835006579 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 266835006580 aspartate aminotransferase; Provisional; Region: PRK05764 266835006581 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 266835006582 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266835006583 homodimer interface [polypeptide binding]; other site 266835006584 catalytic residue [active] 266835006585 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 266835006586 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 266835006587 classical (c) SDRs; Region: SDR_c; cd05233 266835006588 NAD(P) binding site [chemical binding]; other site 266835006589 active site 266835006590 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2979 266835006591 tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178 266835006592 putative metal binding site [ion binding]; other site 266835006593 Predicted sulfurtransferase [General function prediction only]; Region: COG1054 266835006594 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 266835006595 active site residue [active] 266835006596 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 266835006597 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 266835006598 active site 266835006599 intersubunit interface [polypeptide binding]; other site 266835006600 catalytic residue [active] 266835006601 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835006602 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 266835006603 NAD(P) binding site [chemical binding]; other site 266835006604 active site 266835006605 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 266835006606 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266835006607 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 266835006608 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 266835006609 Bacterial protein of unknown function (DUF882); Region: Peptidase_M15_2; pfam05951 266835006610 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 266835006611 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266835006612 active site 266835006613 phosphorylation site [posttranslational modification] 266835006614 intermolecular recognition site; other site 266835006615 dimerization interface [polypeptide binding]; other site 266835006616 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266835006617 Walker A motif; other site 266835006618 ATP binding site [chemical binding]; other site 266835006619 Walker B motif; other site 266835006620 arginine finger; other site 266835006621 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 266835006622 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 266835006623 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_5; cd09610 266835006624 active site 266835006625 Zn binding site [ion binding]; other site 266835006626 Uncharacterized conserved protein [Function unknown]; Region: COG3743 266835006627 aminodeoxychorismate synthase; Provisional; Region: PRK07508 266835006628 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 266835006629 chorismate binding enzyme; Region: Chorismate_bind; cl10555 266835006630 hypothetical protein; Provisional; Region: PRK07546 266835006631 substrate-cofactor binding pocket; other site 266835006632 homodimer interface [polypeptide binding]; other site 266835006633 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 266835006634 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266835006635 catalytic residue [active] 266835006636 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2350 266835006637 Protein of unknown function (DUF3445); Region: DUF3445; pfam11927 266835006638 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266835006639 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266835006640 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 266835006641 putative effector binding pocket; other site 266835006642 dimerization interface [polypeptide binding]; other site 266835006643 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 266835006644 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835006645 NAD(P) binding site [chemical binding]; other site 266835006646 active site 266835006647 Homospermidine synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG5310 266835006648 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 266835006649 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 266835006650 CD73 ecto-5'-nucleotidase and related proteins, N-terminal metallophosphatase domain; Region: MPP_CD73_N; cd07409 266835006651 active site 266835006652 metal binding site [ion binding]; metal-binding site 266835006653 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 266835006654 Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652 266835006655 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 266835006656 ferrochelatase; Reviewed; Region: hemH; PRK00035 266835006657 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 266835006658 C-terminal domain interface [polypeptide binding]; other site 266835006659 active site 266835006660 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 266835006661 active site 266835006662 N-terminal domain interface [polypeptide binding]; other site 266835006663 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 266835006664 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 266835006665 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 266835006666 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 266835006667 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 266835006668 KpsF/GutQ family protein; Region: kpsF; TIGR00393 266835006669 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 266835006670 putative active site [active] 266835006671 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 266835006672 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5338 266835006673 Uncharacterized protein conserved in bacteria (DUF2320); Region: DUF2320; pfam10082 266835006674 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 266835006675 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 266835006676 active site 266835006677 tetramer interface; other site 266835006678 Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951 266835006679 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 266835006680 N-acetyl-D-glucosamine binding site [chemical binding]; other site 266835006681 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 266835006682 SGNH_peri2; putative periplasmic member of the SGNH-family of hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known...; Region: SGNH_hydrolase_peri2; cd01829 266835006683 active site 266835006684 catalytic triad [active] 266835006685 oxyanion hole [active] 266835006686 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 266835006687 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 266835006688 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 266835006689 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 266835006690 active site 266835006691 dimer interface [polypeptide binding]; other site 266835006692 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 266835006693 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 266835006694 active site 266835006695 FMN binding site [chemical binding]; other site 266835006696 substrate binding site [chemical binding]; other site 266835006697 3Fe-4S cluster binding site [ion binding]; other site 266835006698 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 266835006699 domain interface; other site 266835006700 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 266835006701 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 266835006702 tetramer interface [polypeptide binding]; other site 266835006703 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266835006704 catalytic residue [active] 266835006705 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 266835006706 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 266835006707 putative dimer interface [polypeptide binding]; other site 266835006708 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 266835006709 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 266835006710 Serine hydrolase; Region: Ser_hydrolase; cl17834 266835006711 Uncharacterized conserved small protein [Function unknown]; Region: COG5457 266835006712 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 266835006713 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266835006714 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 266835006715 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 266835006716 active site 266835006717 N-formylglutamate amidohydrolase [Amino acid transport and metabolism]; Region: HutG; COG3741 266835006718 Response regulator receiver domain; Region: Response_reg; pfam00072 266835006719 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266835006720 active site 266835006721 phosphorylation site [posttranslational modification] 266835006722 intermolecular recognition site; other site 266835006723 dimerization interface [polypeptide binding]; other site 266835006724 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 266835006725 Protein of unknown function (DUF993); Region: DUF993; pfam06187 266835006726 Transcriptional regulators [Transcription]; Region: PurR; COG1609 266835006727 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 266835006728 DNA binding site [nucleotide binding] 266835006729 domain linker motif; other site 266835006730 Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289 266835006731 putative dimerization interface [polypeptide binding]; other site 266835006732 putative ligand binding site [chemical binding]; other site 266835006733 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 266835006734 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 266835006735 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 266835006736 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 266835006737 Coenzyme A transferase; Region: CoA_trans; smart00882 266835006738 Coenzyme A transferase; Region: CoA_trans; cl17247 266835006739 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 266835006740 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266835006741 substrate binding site [chemical binding]; other site 266835006742 oxyanion hole (OAH) forming residues; other site 266835006743 trimer interface [polypeptide binding]; other site 266835006744 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 266835006745 Gluconobacter oxydans L-sorbosone dehydrogenase-like; Region: ALDH_SNDH; cd07118 266835006746 NAD(P) binding site [chemical binding]; other site 266835006747 catalytic residues [active] 266835006748 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 266835006749 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 266835006750 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 266835006751 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835006752 putative PBP binding loops; other site 266835006753 dimer interface [polypeptide binding]; other site 266835006754 ABC-ATPase subunit interface; other site 266835006755 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 266835006756 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835006757 dimer interface [polypeptide binding]; other site 266835006758 conserved gate region; other site 266835006759 putative PBP binding loops; other site 266835006760 ABC-ATPase subunit interface; other site 266835006761 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 266835006762 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 266835006763 Walker A/P-loop; other site 266835006764 ATP binding site [chemical binding]; other site 266835006765 Q-loop/lid; other site 266835006766 ABC transporter signature motif; other site 266835006767 Walker B; other site 266835006768 D-loop; other site 266835006769 H-loop/switch region; other site 266835006770 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 266835006771 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 266835006772 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12745 266835006773 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835006774 NAD(P) binding site [chemical binding]; other site 266835006775 active site 266835006776 choline dehydrogenase; Validated; Region: PRK02106 266835006777 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 266835006778 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 266835006779 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 266835006780 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266835006781 putative substrate translocation pore; other site 266835006782 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 266835006783 Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568 266835006784 putative catalytic site [active] 266835006785 putative metal binding site [ion binding]; other site 266835006786 putative phosphate binding site [ion binding]; other site 266835006787 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 266835006788 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 266835006789 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266835006790 Walker A/P-loop; other site 266835006791 ATP binding site [chemical binding]; other site 266835006792 Q-loop/lid; other site 266835006793 ABC transporter signature motif; other site 266835006794 Walker B; other site 266835006795 D-loop; other site 266835006796 H-loop/switch region; other site 266835006797 TOBE domain; Region: TOBE_2; pfam08402 266835006798 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 266835006799 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835006800 dimer interface [polypeptide binding]; other site 266835006801 conserved gate region; other site 266835006802 putative PBP binding loops; other site 266835006803 ABC-ATPase subunit interface; other site 266835006804 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 266835006805 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835006806 putative PBP binding loops; other site 266835006807 dimer interface [polypeptide binding]; other site 266835006808 ABC-ATPase subunit interface; other site 266835006809 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 266835006810 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 266835006811 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 266835006812 Iron-containing alcohol dehydrogenases-like, involved in the linear alkylbenzenesulfonate (LAS) degradation pathway; Region: Fe-ADH7; cd08192 266835006813 putative active site [active] 266835006814 metal binding site [ion binding]; metal-binding site 266835006815 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 266835006816 Uncharacterized aldehyde dehydrogenase of Synechococcus sp. PCC 7335 (EDX86601); Region: ALDH_EDX86601; cd07102 266835006817 NAD(P) binding site [chemical binding]; other site 266835006818 catalytic residues [active] 266835006819 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 266835006820 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 266835006821 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 266835006822 amino acid permease (GABA permease); Region: 2A0304; TIGR00907 266835006823 Predicted N-formylglutamate amidohydrolase [Amino acid transport and metabolism]; Region: COG3931 266835006824 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 266835006825 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 266835006826 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 266835006827 putative active site [active] 266835006828 short chain dehydrogenase; Provisional; Region: PRK06172 266835006829 classical (c) SDRs; Region: SDR_c; cd05233 266835006830 NAD(P) binding site [chemical binding]; other site 266835006831 active site 266835006832 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266835006833 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266835006834 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 266835006835 putative effector binding pocket; other site 266835006836 putative dimerization interface [polypeptide binding]; other site 266835006837 Predicted membrane protein [Function unknown]; Region: COG2246 266835006838 GtrA-like protein; Region: GtrA; pfam04138 266835006839 uncharacterized YdjC-like family proteins from bacteria; Region: YdjC_like_3; cd10807 266835006840 putative active site [active] 266835006841 YdjC motif; other site 266835006842 Mg binding site [ion binding]; other site 266835006843 putative homodimer interface [polypeptide binding]; other site 266835006844 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 266835006845 Ligand binding site; other site 266835006846 Putative Catalytic site; other site 266835006847 DXD motif; other site 266835006848 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 266835006849 2-enoyl thioester reductase (ETR) like proteins, child 1; Region: ETR_like_1; cd08291 266835006850 NADP binding site [chemical binding]; other site 266835006851 dimer interface [polypeptide binding]; other site 266835006852 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 266835006853 Acyl-CoA dehydrogenases similar to fadE2; Region: ACAD_FadE2; cd01155 266835006854 FAD binding site [chemical binding]; other site 266835006855 substrate binding site [chemical binding]; other site 266835006856 catalytic base [active] 266835006857 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 266835006858 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835006859 NAD(P) binding site [chemical binding]; other site 266835006860 active site 266835006861 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 266835006862 putative active site [active] 266835006863 putative catalytic site [active] 266835006864 Phosphotransferase enzyme family; Region: APH; pfam01636 266835006865 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 266835006866 putative active site [active] 266835006867 putative substrate binding site [chemical binding]; other site 266835006868 ATP binding site [chemical binding]; other site 266835006869 short chain dehydrogenase; Provisional; Region: PRK06172 266835006870 classical (c) SDRs; Region: SDR_c; cd05233 266835006871 NAD(P) binding site [chemical binding]; other site 266835006872 active site 266835006873 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266835006874 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266835006875 WHG domain; Region: WHG; pfam13305 266835006876 Protein of unknown function (DUF680); Region: DUF680; pfam05079 266835006877 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 266835006878 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 266835006879 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 266835006880 Type 1 glutamine amidotransferase (GATase1)-like domain found in Sinorhizobium meliloti Rm1021 ThuA (SmThuA); Region: GATase1_ThuA; cd03142 266835006881 Sarcosine oxidase gamma subunit [Amino acid transport and metabolism]; Region: COG4583 266835006882 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 266835006883 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 266835006884 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 266835006885 Sarcosine oxidase delta subunit [Amino acid transport and metabolism]; Region: SoxD; COG4311 266835006886 sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373 266835006887 hydroxyglutarate oxidase; Provisional; Region: PRK11728 266835006888 short chain dehydrogenase; Provisional; Region: PRK07478 266835006889 classical (c) SDRs; Region: SDR_c; cd05233 266835006890 NAD(P) binding site [chemical binding]; other site 266835006891 active site 266835006892 Proteins containing SET domain [General function prediction only]; Region: COG2940 266835006893 SET domain; Region: SET; pfam00856 266835006894 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 266835006895 TPR repeat; Region: TPR_11; pfam13414 266835006896 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266835006897 TPR motif; other site 266835006898 binding surface 266835006899 TPR repeat; Region: TPR_11; pfam13414 266835006900 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266835006901 binding surface 266835006902 TPR motif; other site 266835006903 TPR repeat; Region: TPR_11; pfam13414 266835006904 TPR repeat; Region: TPR_11; pfam13414 266835006905 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266835006906 binding surface 266835006907 TPR motif; other site 266835006908 Protein of unknown function (DUF992); Region: DUF992; pfam06186 266835006909 Protein of unknown function (DUF992); Region: DUF992; pfam06186 266835006910 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266835006911 Major Facilitator Superfamily; Region: MFS_1; pfam07690 266835006912 putative substrate translocation pore; other site 266835006913 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 266835006914 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266835006915 active site 266835006916 phosphorylation site [posttranslational modification] 266835006917 intermolecular recognition site; other site 266835006918 dimerization interface [polypeptide binding]; other site 266835006919 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266835006920 DNA binding site [nucleotide binding] 266835006921 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 266835006922 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 266835006923 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 266835006924 Ligand Binding Site [chemical binding]; other site 266835006925 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 266835006926 GAF domain; Region: GAF_3; pfam13492 266835006927 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266835006928 dimer interface [polypeptide binding]; other site 266835006929 phosphorylation site [posttranslational modification] 266835006930 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266835006931 ATP binding site [chemical binding]; other site 266835006932 Mg2+ binding site [ion binding]; other site 266835006933 G-X-G motif; other site 266835006934 potassium-transporting ATPase subunit C; Provisional; Region: PRK13999 266835006935 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 266835006936 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 266835006937 Soluble P-type ATPase [General function prediction only]; Region: COG4087 266835006938 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 266835006939 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 266835006940 dimerization interface [polypeptide binding]; other site 266835006941 metal binding site [ion binding]; metal-binding site 266835006942 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 266835006943 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 266835006944 ligand binding site [chemical binding]; other site 266835006945 flexible hinge region; other site 266835006946 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 266835006947 non-specific DNA interactions [nucleotide binding]; other site 266835006948 DNA binding site [nucleotide binding] 266835006949 sequence specific DNA binding site [nucleotide binding]; other site 266835006950 putative cAMP binding site [chemical binding]; other site 266835006951 Protein of unknown function (DUF982); Region: DUF982; pfam06169 266835006952 Acyltransferase family; Region: Acyl_transf_3; pfam01757 266835006953 Protein of unknown function (DUF2569); Region: DUF2569; pfam10754 266835006954 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 266835006955 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 266835006956 ligand binding site [chemical binding]; other site 266835006957 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 266835006958 Coenzyme A binding pocket [chemical binding]; other site 266835006959 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5343 266835006960 hypothetical protein; Provisional; Region: PRK00736 266835006961 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 266835006962 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266835006963 Walker A/P-loop; other site 266835006964 ATP binding site [chemical binding]; other site 266835006965 Q-loop/lid; other site 266835006966 ABC transporter signature motif; other site 266835006967 Walker B; other site 266835006968 D-loop; other site 266835006969 H-loop/switch region; other site 266835006970 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 266835006971 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 266835006972 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 266835006973 TM-ABC transporter signature motif; other site 266835006974 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 266835006975 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 266835006976 TM-ABC transporter signature motif; other site 266835006977 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 266835006978 active site 266835006979 catalytic motif [active] 266835006980 Zn binding site [ion binding]; other site 266835006981 purine nucleoside phosphorylase; Provisional; Region: PRK08202 266835006982 thymidine phosphorylase; Region: T_phosphoryl; TIGR02643 266835006983 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 266835006984 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 266835006985 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 266835006986 Predicted aspartyl protease [General function prediction only]; Region: COG3577 266835006987 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 266835006988 catalytic motif [active] 266835006989 Catalytic residue [active] 266835006990 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 266835006991 active site 266835006992 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 266835006993 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 266835006994 active site 266835006995 purine riboside binding site [chemical binding]; other site 266835006996 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 266835006997 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266835006998 S-adenosylmethionine binding site [chemical binding]; other site 266835006999 ABC1 family; Region: ABC1; cl17513 266835007000 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 266835007001 bifunctional SbtC-like/phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Provisional; Region: PRK13982 266835007002 Flavoprotein; Region: Flavoprotein; pfam02441 266835007003 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 266835007004 Invasion protein B, involved in pathogenesis [General function prediction only]; Region: COG5342 266835007005 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_9; cd04666 266835007006 nudix motif; other site 266835007007 PAS fold; Region: PAS_4; pfam08448 266835007008 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 266835007009 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266835007010 metal binding site [ion binding]; metal-binding site 266835007011 active site 266835007012 I-site; other site 266835007013 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 266835007014 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 266835007015 Protein of unknown function (DUF3363); Region: DUF3363; pfam11843 266835007016 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 266835007017 Predicted membrane protein [Function unknown]; Region: COG3556 266835007018 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 266835007019 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 266835007020 minor groove reading motif; other site 266835007021 helix-hairpin-helix signature motif; other site 266835007022 substrate binding pocket [chemical binding]; other site 266835007023 active site 266835007024 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 266835007025 Integral membrane protein [Function unknown]; Region: COG5488 266835007026 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 266835007027 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 266835007028 Helix-turn-helix domain; Region: HTH_18; pfam12833 266835007029 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 266835007030 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 266835007031 DNA binding site [nucleotide binding] 266835007032 active site 266835007033 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 266835007034 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 266835007035 substrate binding site [chemical binding]; other site 266835007036 dimer interface [polypeptide binding]; other site 266835007037 ATP binding site [chemical binding]; other site 266835007038 amidase; Provisional; Region: PRK07486 266835007039 Amidase; Region: Amidase; cl11426 266835007040 LysE type translocator; Region: LysE; cl00565 266835007041 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 266835007042 active site 266835007043 tetramer interface [polypeptide binding]; other site 266835007044 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 266835007045 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 266835007046 putative dimer interface [polypeptide binding]; other site 266835007047 Uncharacterized small protein [Function unknown]; Region: COG5568 266835007048 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 266835007049 active site 266835007050 phosphorylation site [posttranslational modification] 266835007051 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 266835007052 30S subunit binding site; other site 266835007053 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 266835007054 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 266835007055 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 266835007056 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 266835007057 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 266835007058 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 266835007059 Walker A/P-loop; other site 266835007060 ATP binding site [chemical binding]; other site 266835007061 Q-loop/lid; other site 266835007062 ABC transporter signature motif; other site 266835007063 Walker B; other site 266835007064 D-loop; other site 266835007065 H-loop/switch region; other site 266835007066 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1934 266835007067 OstA-like protein; Region: OstA; pfam03968 266835007068 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5375 266835007069 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 266835007070 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 266835007071 tandem repeat interface [polypeptide binding]; other site 266835007072 oligomer interface [polypeptide binding]; other site 266835007073 active site residues [active] 266835007074 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 266835007075 IHF dimer interface [polypeptide binding]; other site 266835007076 IHF - DNA interface [nucleotide binding]; other site 266835007077 ornithine cyclodeaminase; Validated; Region: PRK06141 266835007078 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 266835007079 EVE domain; Region: EVE; cl00728 266835007080 hypothetical protein; Provisional; Region: PRK02268 266835007081 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266835007082 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_11; cd07261 266835007083 putative dimer interface [polypeptide binding]; other site 266835007084 Predicted transcriptional regulator [Transcription]; Region: COG2378 266835007085 HTH domain; Region: HTH_11; pfam08279 266835007086 WYL domain; Region: WYL; pfam13280 266835007087 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 266835007088 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266835007089 S-adenosylmethionine binding site [chemical binding]; other site 266835007090 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 266835007091 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 266835007092 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 266835007093 lipoprotein signal peptidase; Provisional; Region: PRK14795 266835007094 lipoprotein signal peptidase; Provisional; Region: PRK14787 266835007095 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 266835007096 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 266835007097 NADP binding site [chemical binding]; other site 266835007098 dimer interface [polypeptide binding]; other site 266835007099 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 266835007100 PAS domain; Region: PAS; smart00091 266835007101 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266835007102 dimer interface [polypeptide binding]; other site 266835007103 phosphorylation site [posttranslational modification] 266835007104 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266835007105 ATP binding site [chemical binding]; other site 266835007106 Mg2+ binding site [ion binding]; other site 266835007107 G-X-G motif; other site 266835007108 Response regulator receiver domain; Region: Response_reg; pfam00072 266835007109 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266835007110 active site 266835007111 phosphorylation site [posttranslational modification] 266835007112 intermolecular recognition site; other site 266835007113 dimerization interface [polypeptide binding]; other site 266835007114 Putative hemolysin [General function prediction only]; Region: COG3176 266835007115 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3801 266835007116 Predicted membrane protein [Function unknown]; Region: COG2860 266835007117 UPF0126 domain; Region: UPF0126; pfam03458 266835007118 UPF0126 domain; Region: UPF0126; pfam03458 266835007119 heat shock protein GrpE; Provisional; Region: PRK14141 266835007120 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 266835007121 dimer interface [polypeptide binding]; other site 266835007122 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 266835007123 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 266835007124 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 266835007125 putative di-iron ligands [ion binding]; other site 266835007126 intracellular protease, PfpI family; Region: PfpI; TIGR01382 266835007127 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 266835007128 conserved cys residue [active] 266835007129 choline dehydrogenase; Validated; Region: PRK02106 266835007130 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 266835007131 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3749 266835007132 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 266835007133 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 266835007134 Active Sites [active] 266835007135 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 266835007136 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 266835007137 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 266835007138 Protein of unknown function (DUF2849); Region: DUF2849; pfam11011 266835007139 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 266835007140 siroheme synthase; Provisional; Region: cysG; PRK10637 266835007141 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 266835007142 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 266835007143 active site 266835007144 SAM binding site [chemical binding]; other site 266835007145 homodimer interface [polypeptide binding]; other site 266835007146 Protein required for attachment to host cells [Cell motility and secretion]; Region: COG5622 266835007147 putative cation:proton antiport protein; Provisional; Region: PRK10669 266835007148 Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651 266835007149 TrkA-N domain; Region: TrkA_N; pfam02254 266835007150 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 266835007151 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266835007152 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR4; cd08270 266835007153 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 266835007154 putative NAD(P) binding site [chemical binding]; other site 266835007155 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 266835007156 classical (c) SDRs; Region: SDR_c; cd05233 266835007157 NAD(P) binding site [chemical binding]; other site 266835007158 active site 266835007159 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 266835007160 Transglycosylase; Region: Transgly; pfam00912 266835007161 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 266835007162 Ion channel; Region: Ion_trans_2; pfam07885 266835007163 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 266835007164 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 266835007165 ligand binding site [chemical binding]; other site 266835007166 flexible hinge region; other site 266835007167 Heme NO binding associated; Region: HNOBA; pfam07701 266835007168 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 266835007169 cyclase homology domain; Region: CHD; cd07302 266835007170 nucleotidyl binding site; other site 266835007171 metal binding site [ion binding]; metal-binding site 266835007172 dimer interface [polypeptide binding]; other site 266835007173 GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100 266835007174 Ras-related in brain (Rab) family of small guanosine triphosphatases (GTPases); Region: Rab; cd00154 266835007175 Rab subfamily motif 1 (RabSF1); other site 266835007176 G1 box; other site 266835007177 GTP/Mg2+ binding site [chemical binding]; other site 266835007178 Rab subfamily motif 2 (RabSF2); other site 266835007179 Switch I region; other site 266835007180 G2 box; other site 266835007181 effector interaction site; other site 266835007182 GDI interaction site; other site 266835007183 Rab family motif 1 (RabF1); other site 266835007184 GEF interaction site [polypeptide binding]; other site 266835007185 Rab family motif 2 (RabF2); other site 266835007186 G3 box; other site 266835007187 Switch II region; other site 266835007188 Rab family motif 3 (RabF3); other site 266835007189 Rab family motif 4 (RabF4); other site 266835007190 Rab family motif 5 (RabF5); other site 266835007191 Rab subfamily motif 3 (RabSF3); other site 266835007192 G4 box; other site 266835007193 G5 box; other site 266835007194 Rab subfamily motif 4 (RabSF4); other site 266835007195 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 266835007196 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 266835007197 ligand binding site [chemical binding]; other site 266835007198 Protein of unknown function (DUF3584); Region: DUF3584; pfam12128 266835007199 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 266835007200 ABC-ATPase subunit interface; other site 266835007201 Predicted glycosyl transferase [General function prediction only]; Region: COG4671 266835007202 Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369 266835007203 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 266835007204 putative ADP-binding pocket [chemical binding]; other site 266835007205 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 266835007206 Predicted glycosyl transferase [General function prediction only]; Region: COG4671 266835007207 Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369 266835007208 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266835007209 S-adenosylmethionine binding site [chemical binding]; other site 266835007210 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 266835007211 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 266835007212 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 266835007213 Walker A/P-loop; other site 266835007214 ATP binding site [chemical binding]; other site 266835007215 Q-loop/lid; other site 266835007216 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 266835007217 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266835007218 ABC transporter signature motif; other site 266835007219 Walker B; other site 266835007220 D-loop; other site 266835007221 H-loop/switch region; other site 266835007222 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 266835007223 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 266835007224 ligand binding site [chemical binding]; other site 266835007225 flexible hinge region; other site 266835007226 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 266835007227 Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u4; cd10928 266835007228 NodB motif; other site 266835007229 putative active site [active] 266835007230 putative catalytic site [active] 266835007231 putative Zn binding site [ion binding]; other site 266835007232 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 266835007233 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 266835007234 Protein of unknown function (DUF3095); Region: DUF3095; pfam11294 266835007235 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 266835007236 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835007237 NAD(P) binding site [chemical binding]; other site 266835007238 active site 266835007239 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 266835007240 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 266835007241 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 266835007242 cyclase homology domain; Region: CHD; cd07302 266835007243 nucleotidyl binding site; other site 266835007244 metal binding site [ion binding]; metal-binding site 266835007245 dimer interface [polypeptide binding]; other site 266835007246 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 266835007247 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266835007248 Walker A/P-loop; other site 266835007249 ATP binding site [chemical binding]; other site 266835007250 Q-loop/lid; other site 266835007251 ABC transporter signature motif; other site 266835007252 Walker B; other site 266835007253 D-loop; other site 266835007254 H-loop/switch region; other site 266835007255 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 266835007256 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266835007257 Walker A/P-loop; other site 266835007258 ATP binding site [chemical binding]; other site 266835007259 Q-loop/lid; other site 266835007260 ABC transporter signature motif; other site 266835007261 Walker B; other site 266835007262 D-loop; other site 266835007263 H-loop/switch region; other site 266835007264 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 266835007265 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_4; cd08500 266835007266 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 266835007267 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 266835007268 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835007269 dimer interface [polypeptide binding]; other site 266835007270 conserved gate region; other site 266835007271 putative PBP binding loops; other site 266835007272 ABC-ATPase subunit interface; other site 266835007273 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 266835007274 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 266835007275 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835007276 dimer interface [polypeptide binding]; other site 266835007277 conserved gate region; other site 266835007278 putative PBP binding loops; other site 266835007279 ABC-ATPase subunit interface; other site 266835007280 S-adenosyl-L-methionine methyltransferase; Region: Methyltransf_17; pfam12692 266835007281 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 266835007282 cyclase homology domain; Region: CHD; cd07302 266835007283 nucleotidyl binding site; other site 266835007284 metal binding site [ion binding]; metal-binding site 266835007285 dimer interface [polypeptide binding]; other site 266835007286 putative acetyltransferase YhhY; Provisional; Region: PRK10140 266835007287 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 266835007288 Coenzyme A binding pocket [chemical binding]; other site 266835007289 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 266835007290 cyclase homology domain; Region: CHD; cd07302 266835007291 nucleotidyl binding site; other site 266835007292 metal binding site [ion binding]; metal-binding site 266835007293 dimer interface [polypeptide binding]; other site 266835007294 Predicted integral membrane protein [Function unknown]; Region: COG5616 266835007295 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266835007296 TPR motif; other site 266835007297 binding surface 266835007298 Tetratricopeptide repeat; Region: TPR_16; pfam13432 266835007299 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266835007300 TPR motif; other site 266835007301 binding surface 266835007302 Double zinc ribbon; Region: DZR; pfam12773 266835007303 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 266835007304 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 266835007305 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 266835007306 cyclase homology domain; Region: CHD; cd07302 266835007307 nucleotidyl binding site; other site 266835007308 metal binding site [ion binding]; metal-binding site 266835007309 dimer interface [polypeptide binding]; other site 266835007310 Predicted ATPase [General function prediction only]; Region: COG3899 266835007311 AAA ATPase domain; Region: AAA_16; pfam13191 266835007312 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266835007313 binding surface 266835007314 TPR motif; other site 266835007315 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 266835007316 putative catalytic residues [active] 266835007317 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 266835007318 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 266835007319 active site 266835007320 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 266835007321 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 266835007322 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 266835007323 putative active site [active] 266835007324 putative metal binding site [ion binding]; other site 266835007325 DDE superfamily endonuclease; Region: DDE_3; pfam13358 266835007326 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 266835007327 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 266835007328 HlyD family secretion protein; Region: HlyD_3; pfam13437 266835007329 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 266835007330 Mlo family; Region: Mlo; pfam03094 266835007331 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 266835007332 Mechanosensitive ion channel; Region: MS_channel; pfam00924 266835007333 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 266835007334 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 266835007335 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 266835007336 catalytic site [active] 266835007337 putative active site [active] 266835007338 putative substrate binding site [chemical binding]; other site 266835007339 hypothetical protein; Validated; Region: PRK09104 266835007340 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680 266835007341 metal binding site [ion binding]; metal-binding site 266835007342 putative dimer interface [polypeptide binding]; other site 266835007343 5'-3' exonuclease; Region: 53EXOc; smart00475 266835007344 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 266835007345 active site 266835007346 metal binding site 1 [ion binding]; metal-binding site 266835007347 putative 5' ssDNA interaction site; other site 266835007348 metal binding site 3; metal-binding site 266835007349 metal binding site 2 [ion binding]; metal-binding site 266835007350 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 266835007351 putative DNA binding site [nucleotide binding]; other site 266835007352 putative metal binding site [ion binding]; other site 266835007353 DNA polymerase I - 3'-5' exonuclease and polymerase domains [DNA replication, recombination, and repair]; Region: PolA; COG0749 266835007354 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 266835007355 active site 266835007356 catalytic site [active] 266835007357 substrate binding site [chemical binding]; other site 266835007358 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 266835007359 active site 266835007360 DNA binding site [nucleotide binding] 266835007361 catalytic site [active] 266835007362 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 266835007363 metal binding site 2 [ion binding]; metal-binding site 266835007364 putative DNA binding helix; other site 266835007365 metal binding site 1 [ion binding]; metal-binding site 266835007366 dimer interface [polypeptide binding]; other site 266835007367 structural Zn2+ binding site [ion binding]; other site 266835007368 Caspase domain; Region: Peptidase_C14; pfam00656 266835007369 FOG: WD40 repeat [General function prediction only]; Region: COG2319 266835007370 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 266835007371 structural tetrad; other site 266835007372 FOG: WD40 repeat [General function prediction only]; Region: COG2319 266835007373 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 266835007374 Uncharacterized protein containing caspase domain [General function prediction only]; Region: COG4249 266835007375 Caspase domain; Region: Peptidase_C14; pfam00656 266835007376 Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility; Region: MEMO_like; cd07361 266835007377 putative ligand binding pocket/active site [active] 266835007378 putative metal binding site [ion binding]; other site 266835007379 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 266835007380 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 266835007381 putative active site [active] 266835007382 putative metal binding site [ion binding]; other site 266835007383 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642 266835007384 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642 266835007385 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 266835007386 Secreted trypsin-like serine protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5640 266835007387 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cd00190 266835007388 cleavage site 266835007389 active site 266835007390 substrate binding sites [chemical binding]; other site 266835007391 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 266835007392 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 266835007393 active site 266835007394 catalytic tetrad [active] 266835007395 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 266835007396 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 266835007397 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 266835007398 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 266835007399 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 266835007400 Walker A/P-loop; other site 266835007401 ATP binding site [chemical binding]; other site 266835007402 Q-loop/lid; other site 266835007403 ABC transporter signature motif; other site 266835007404 Walker B; other site 266835007405 D-loop; other site 266835007406 H-loop/switch region; other site 266835007407 TOBE domain; Region: TOBE_2; pfam08402 266835007408 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 266835007409 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835007410 dimer interface [polypeptide binding]; other site 266835007411 conserved gate region; other site 266835007412 putative PBP binding loops; other site 266835007413 ABC-ATPase subunit interface; other site 266835007414 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 266835007415 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835007416 dimer interface [polypeptide binding]; other site 266835007417 conserved gate region; other site 266835007418 putative PBP binding loops; other site 266835007419 ABC-ATPase subunit interface; other site 266835007420 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 266835007421 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 266835007422 Transcriptional regulators [Transcription]; Region: PurR; COG1609 266835007423 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 266835007424 DNA binding site [nucleotide binding] 266835007425 domain linker motif; other site 266835007426 Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271 266835007427 ligand binding site [chemical binding]; other site 266835007428 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG0362 266835007429 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 266835007430 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 266835007431 Uncharacterized protein, homolog of Cu resistance protein CopC [General function prediction only]; Region: CopC; COG2372 266835007432 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 266835007433 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 266835007434 Copper(I)-binding protein [Inorganic ion transport and metabolism]; Region: COG2847 266835007435 Transcriptional regulators [Transcription]; Region: GntR; COG1802 266835007436 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 266835007437 DNA-binding site [nucleotide binding]; DNA binding site 266835007438 FCD domain; Region: FCD; pfam07729 266835007439 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 266835007440 galactarate dehydratase; Region: galactar-dH20; TIGR03248 266835007441 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 266835007442 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 266835007443 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 266835007444 active site 266835007445 catalytic tetrad [active] 266835007446 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 266835007447 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_2; cd06310 266835007448 putative ligand binding site [chemical binding]; other site 266835007449 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 266835007450 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 266835007451 Walker A/P-loop; other site 266835007452 ATP binding site [chemical binding]; other site 266835007453 Q-loop/lid; other site 266835007454 ABC transporter signature motif; other site 266835007455 Walker B; other site 266835007456 D-loop; other site 266835007457 H-loop/switch region; other site 266835007458 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 266835007459 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 266835007460 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 266835007461 TM-ABC transporter signature motif; other site 266835007462 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 266835007463 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 266835007464 putative NAD(P) binding site [chemical binding]; other site 266835007465 catalytic Zn binding site [ion binding]; other site 266835007466 structural Zn binding site [ion binding]; other site 266835007467 phosphonates metabolism transcriptional regulator PhnF; Region: C_P_lyase_phnF; TIGR02325 266835007468 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266835007469 DNA-binding site [nucleotide binding]; DNA binding site 266835007470 UTRA domain; Region: UTRA; pfam07702 266835007471 Phosphonate metabolism protein PhnG; Region: PhnG; pfam06754 266835007472 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnH; COG3625 266835007473 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnI; COG3626 266835007474 fosfomycin resistance protein FosB; Provisional; Region: PRK04101 266835007475 FosX, a fosfomycin resistance protein, catalyzes the addition of a water molecule to the C1 position of the antibiotic with inversion of configuration at C1; Region: FosX; cd08364 266835007476 dimer interface [polypeptide binding]; other site 266835007477 active site 266835007478 Mn binding site [ion binding]; other site 266835007479 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnJ; COG3627 266835007480 phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701 266835007481 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266835007482 Walker A/P-loop; other site 266835007483 ATP binding site [chemical binding]; other site 266835007484 Q-loop/lid; other site 266835007485 ABC transporter signature motif; other site 266835007486 Walker B; other site 266835007487 D-loop; other site 266835007488 H-loop/switch region; other site 266835007489 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 266835007490 ABC-type phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PhnL; COG4778 266835007491 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266835007492 Walker A/P-loop; other site 266835007493 ATP binding site [chemical binding]; other site 266835007494 Q-loop/lid; other site 266835007495 ABC transporter signature motif; other site 266835007496 Walker B; other site 266835007497 D-loop; other site 266835007498 H-loop/switch region; other site 266835007499 phosphonate metabolim protein, transferase hexapeptide repeat family; Region: phn_thr-fam; TIGR03308 266835007500 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 266835007501 trimer interface [polypeptide binding]; other site 266835007502 active site 266835007503 substrate binding site [chemical binding]; other site 266835007504 CoA binding site [chemical binding]; other site 266835007505 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5255 266835007506 Domain of unknown function (DUF1868); Region: 2H-phosphodiest; pfam08975 266835007507 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 266835007508 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 266835007509 Walker A/P-loop; other site 266835007510 ATP binding site [chemical binding]; other site 266835007511 Q-loop/lid; other site 266835007512 ABC transporter signature motif; other site 266835007513 Walker B; other site 266835007514 D-loop; other site 266835007515 H-loop/switch region; other site 266835007516 phosphonate ABC transporter, periplasmic phosphonate binding protein; Region: PhnD; TIGR03431 266835007517 ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport and metabolism]; Region: COG3639 266835007518 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835007519 dimer interface [polypeptide binding]; other site 266835007520 conserved gate region; other site 266835007521 ABC-ATPase subunit interface; other site 266835007522 ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport and metabolism]; Region: COG3639 266835007523 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 266835007524 ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport and metabolism]; Region: COG3639 266835007525 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835007526 dimer interface [polypeptide binding]; other site 266835007527 conserved gate region; other site 266835007528 ABC-ATPase subunit interface; other site 266835007529 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 266835007530 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 266835007531 DNA interaction; other site 266835007532 Metal-binding active site; metal-binding site 266835007533 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 266835007534 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 266835007535 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 266835007536 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 266835007537 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 266835007538 AP (apurinic/apyrimidinic) site pocket; other site 266835007539 DNA interaction; other site 266835007540 Metal-binding active site; metal-binding site 266835007541 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 266835007542 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 266835007543 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 266835007544 DNA interaction; other site 266835007545 Metal-binding active site; metal-binding site 266835007546 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 266835007547 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 266835007548 active site pocket [active] 266835007549 Transcriptional regulators [Transcription]; Region: FadR; COG2186 266835007550 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266835007551 DNA-binding site [nucleotide binding]; DNA binding site 266835007552 FCD domain; Region: FCD; pfam07729 266835007553 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 266835007554 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 266835007555 ligand binding site [chemical binding]; other site 266835007556 NAD binding site [chemical binding]; other site 266835007557 dimerization interface [polypeptide binding]; other site 266835007558 catalytic site [active] 266835007559 amidase; Provisional; Region: PRK07056 266835007560 amidase; Validated; Region: PRK05962 266835007561 Uncharacterized conserved protein [Function unknown]; Region: COG3791 266835007562 short chain dehydrogenase; Provisional; Region: PRK08303 266835007563 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835007564 NAD(P) binding site [chemical binding]; other site 266835007565 active site 266835007566 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266835007567 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266835007568 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 266835007569 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266835007570 putative substrate translocation pore; other site 266835007571 Cupin; Region: Cupin_6; pfam12852 266835007572 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266835007573 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 266835007574 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266835007575 Cupin; Region: Cupin_6; pfam12852 266835007576 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266835007577 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 266835007578 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266835007579 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 266835007580 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266835007581 ABC transporter signature motif; other site 266835007582 Walker B; other site 266835007583 D-loop; other site 266835007584 H-loop/switch region; other site 266835007585 TOBE domain; Region: TOBE_2; pfam08402 266835007586 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 266835007587 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266835007588 Walker A/P-loop; other site 266835007589 ATP binding site [chemical binding]; other site 266835007590 Q-loop/lid; other site 266835007591 ABC transporter signature motif; other site 266835007592 Walker B; other site 266835007593 D-loop; other site 266835007594 H-loop/switch region; other site 266835007595 TOBE domain; Region: TOBE_2; pfam08402 266835007596 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 266835007597 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835007598 dimer interface [polypeptide binding]; other site 266835007599 conserved gate region; other site 266835007600 putative PBP binding loops; other site 266835007601 ABC-ATPase subunit interface; other site 266835007602 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 266835007603 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835007604 dimer interface [polypeptide binding]; other site 266835007605 conserved gate region; other site 266835007606 putative PBP binding loops; other site 266835007607 ABC-ATPase subunit interface; other site 266835007608 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 266835007609 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 266835007610 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266835007611 Walker A/P-loop; other site 266835007612 ATP binding site [chemical binding]; other site 266835007613 Q-loop/lid; other site 266835007614 ABC transporter signature motif; other site 266835007615 Walker B; other site 266835007616 D-loop; other site 266835007617 H-loop/switch region; other site 266835007618 TOBE domain; Region: TOBE_2; pfam08402 266835007619 Uncharacterized conserved protein [Function unknown]; Region: COG5441 266835007620 Uncharacterized protein family (UPF0261); Region: UPF0261; pfam06792 266835007621 TIM-barrel signal transduction protein; Region: TIM-br_sig_trns; pfam09370 266835007622 Thermophilic glucose-6-phosphate isomerase and related metalloenzymes [Carbohydrate transport and metabolism / General function prediction only]; Region: COG2140 266835007623 Cupin domain; Region: Cupin_2; pfam07883 266835007624 Domain of unknown function (DUF4304); Region: DUF4304; pfam14137 266835007625 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 266835007626 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 266835007627 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 266835007628 active site 266835007629 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 266835007630 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_13; cd08517 266835007631 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 266835007632 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835007633 dimer interface [polypeptide binding]; other site 266835007634 conserved gate region; other site 266835007635 putative PBP binding loops; other site 266835007636 ABC-ATPase subunit interface; other site 266835007637 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 266835007638 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835007639 dimer interface [polypeptide binding]; other site 266835007640 conserved gate region; other site 266835007641 putative PBP binding loops; other site 266835007642 ABC-ATPase subunit interface; other site 266835007643 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 266835007644 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266835007645 Walker A/P-loop; other site 266835007646 ATP binding site [chemical binding]; other site 266835007647 Q-loop/lid; other site 266835007648 ABC transporter signature motif; other site 266835007649 Walker B; other site 266835007650 D-loop; other site 266835007651 H-loop/switch region; other site 266835007652 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 266835007653 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 266835007654 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266835007655 Walker A/P-loop; other site 266835007656 ATP binding site [chemical binding]; other site 266835007657 Q-loop/lid; other site 266835007658 ABC transporter signature motif; other site 266835007659 Walker B; other site 266835007660 D-loop; other site 266835007661 H-loop/switch region; other site 266835007662 L-2-amino-thiazoline-4-carboxylic acid hydrolase; Region: ATC_hydrolase; pfam14196 266835007663 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 266835007664 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 266835007665 Walker A/P-loop; other site 266835007666 ATP binding site [chemical binding]; other site 266835007667 Q-loop/lid; other site 266835007668 ABC transporter signature motif; other site 266835007669 Walker B; other site 266835007670 D-loop; other site 266835007671 H-loop/switch region; other site 266835007672 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 266835007673 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 266835007674 TM-ABC transporter signature motif; other site 266835007675 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 266835007676 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_2; cd06310 266835007677 putative ligand binding site [chemical binding]; other site 266835007678 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 266835007679 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 266835007680 DNA binding residues [nucleotide binding] 266835007681 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 266835007682 Tagatose-1,6-bisphosphate aldolase [Carbohydrate transport and metabolism]; Region: LacD; COG3684 266835007683 catalytic residue [active] 266835007684 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 266835007685 N-acetylmannosamine kinase; Provisional; Region: PRK05082 266835007686 nucleotide binding site [chemical binding]; other site 266835007687 Chloramphenicol (Cm) phosphotransferase (CPT). Cm-inactivating enzyme; modifies the primary (C-3) hydroxyl of the antibiotic. Related structurally to shikimate kinase II; Region: CPT; cl17391 266835007688 AAA domain; Region: AAA_33; pfam13671 266835007689 P-loop motif; other site 266835007690 ATP binding site [chemical binding]; other site 266835007691 Chloramphenicol (Cm) binding site [chemical binding]; other site 266835007692 catalytic residue [active] 266835007693 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 266835007694 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 266835007695 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 266835007696 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 266835007697 NADH(P)-binding; Region: NAD_binding_10; pfam13460 266835007698 NAD binding site [chemical binding]; other site 266835007699 substrate binding site [chemical binding]; other site 266835007700 putative active site [active] 266835007701 Predicted protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: COG3531 266835007702 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 266835007703 catalytic residues [active] 266835007704 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266835007705 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266835007706 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 266835007707 putative effector binding pocket; other site 266835007708 dimerization interface [polypeptide binding]; other site 266835007709 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 266835007710 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain [Transcription]; Region: COG3609 266835007711 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 266835007712 Peptidase family M23; Region: Peptidase_M23; pfam01551 266835007713 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 266835007714 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266835007715 putative substrate translocation pore; other site 266835007716 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266835007717 Predicted integral membrane protein [Function unknown]; Region: COG3548 266835007718 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 266835007719 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 266835007720 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 266835007721 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 266835007722 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 266835007723 Clp amino terminal domain; Region: Clp_N; pfam02861 266835007724 Clp amino terminal domain; Region: Clp_N; pfam02861 266835007725 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266835007726 Walker A motif; other site 266835007727 ATP binding site [chemical binding]; other site 266835007728 Walker B motif; other site 266835007729 arginine finger; other site 266835007730 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266835007731 Walker A motif; other site 266835007732 ATP binding site [chemical binding]; other site 266835007733 Walker B motif; other site 266835007734 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 266835007735 Domain of unknown function (DUF4167); Region: DUF4167; pfam13763 266835007736 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 266835007737 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266835007738 S-adenosylmethionine binding site [chemical binding]; other site 266835007739 peptide chain release factor 1; Validated; Region: prfA; PRK00591 266835007740 This domain is found in peptide chain release factors; Region: PCRF; smart00937 266835007741 RF-1 domain; Region: RF-1; pfam00472 266835007742 Signal transduction protein containing GAF and PtsI domains [Signal transduction mechanisms]; Region: PtsP; COG3605 266835007743 GAF domain; Region: GAF; pfam01590 266835007744 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 266835007745 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 266835007746 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 266835007747 aspartate kinase; Reviewed; Region: PRK06635 266835007748 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 266835007749 putative nucleotide binding site [chemical binding]; other site 266835007750 putative catalytic residues [active] 266835007751 putative Mg ion binding site [ion binding]; other site 266835007752 putative aspartate binding site [chemical binding]; other site 266835007753 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 266835007754 putative allosteric regulatory site; other site 266835007755 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 266835007756 putative allosteric regulatory residue; other site 266835007757 PAS domain; Region: PAS_9; pfam13426 266835007758 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 266835007759 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 266835007760 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 266835007761 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266835007762 metal binding site [ion binding]; metal-binding site 266835007763 active site 266835007764 I-site; other site 266835007765 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3554 266835007766 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 266835007767 Methyltransferase domain; Region: Methyltransf_11; pfam08241 266835007768 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 266835007769 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 266835007770 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 266835007771 active site 266835007772 dimer interface [polypeptide binding]; other site 266835007773 non-prolyl cis peptide bond; other site 266835007774 insertion regions; other site 266835007775 Predicted transcription regulator, contains HTH domain (MarR family) [Transcription]; Region: COG5631 266835007776 MarR family; Region: MarR_2; cl17246 266835007777 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 266835007778 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5319 266835007779 nitrilase; Region: PLN02798 266835007780 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 266835007781 putative active site [active] 266835007782 catalytic triad [active] 266835007783 dimer interface [polypeptide binding]; other site 266835007784 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 266835007785 GSH binding site [chemical binding]; other site 266835007786 catalytic residues [active] 266835007787 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 266835007788 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 266835007789 active site 266835007790 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 266835007791 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 266835007792 Flp pilus assembly protein, pilin Flp [Intracellular trafficking and secretion]; Region: Flp; COG3847 266835007793 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 266835007794 active site 266835007795 8-oxo-dGMP binding site [chemical binding]; other site 266835007796 nudix motif; other site 266835007797 metal binding site [ion binding]; metal-binding site 266835007798 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 266835007799 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 266835007800 Coenzyme A binding pocket [chemical binding]; other site 266835007801 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 266835007802 heterotetramer interface [polypeptide binding]; other site 266835007803 active site pocket [active] 266835007804 cleavage site 266835007805 Uncharacterized protein containing caspase domain [General function prediction only]; Region: COG4249 266835007806 Caspase domain; Region: Peptidase_C14; pfam00656 266835007807 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 266835007808 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266835007809 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266835007810 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03002 266835007811 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 266835007812 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 266835007813 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 266835007814 ATP binding site [chemical binding]; other site 266835007815 putative Mg++ binding site [ion binding]; other site 266835007816 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 266835007817 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 266835007818 nucleotide binding region [chemical binding]; other site 266835007819 ATP-binding site [chemical binding]; other site 266835007820 SEC-C motif; Region: SEC-C; pfam02810 266835007821 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 266835007822 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 266835007823 Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653 266835007824 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 266835007825 Uncharacterized protein, putative amidase [General function prediction only]; Region: COG1402 266835007826 Uncharacterized conserved protein [Function unknown]; Region: COG3391 266835007827 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 266835007828 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 266835007829 Predicted membrane protein [Function unknown]; Region: COG1238 266835007830 Disulfide bond formation protein DsbB [Posttranslational modification, protein turnover, chaperones]; Region: DsbB; COG1495 266835007831 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 266835007832 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 266835007833 active site 266835007834 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 266835007835 endonuclease III; Region: ENDO3c; smart00478 266835007836 minor groove reading motif; other site 266835007837 helix-hairpin-helix signature motif; other site 266835007838 substrate binding pocket [chemical binding]; other site 266835007839 active site 266835007840 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 266835007841 Glutamyl- and glutaminyl-tRNA synthetases [Translation, ribosomal structure and biogenesis]; Region: GlnS; COG0008 266835007842 active site 266835007843 HIGH motif; other site 266835007844 nucleotide binding site [chemical binding]; other site 266835007845 active site 266835007846 KMSKS motif; other site 266835007847 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 266835007848 EamA-like transporter family; Region: EamA; pfam00892 266835007849 EamA-like transporter family; Region: EamA; pfam00892 266835007850 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 266835007851 short chain dehydrogenase; Provisional; Region: PRK05993 266835007852 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 266835007853 NADP binding site [chemical binding]; other site 266835007854 active site 266835007855 steroid binding site; other site 266835007856 Hypoxia induced protein conserved region; Region: HIG_1_N; pfam04588 266835007857 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 266835007858 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 266835007859 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 266835007860 Ligand binding site [chemical binding]; other site 266835007861 Electron transfer flavoprotein domain; Region: ETF; pfam01012 266835007862 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 266835007863 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 266835007864 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 266835007865 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07530 266835007866 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 266835007867 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 266835007868 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266835007869 putative active site [active] 266835007870 heme pocket [chemical binding]; other site 266835007871 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266835007872 PAS fold; Region: PAS_3; pfam08447 266835007873 putative active site [active] 266835007874 heme pocket [chemical binding]; other site 266835007875 PAS fold; Region: PAS; pfam00989 266835007876 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266835007877 putative active site [active] 266835007878 heme pocket [chemical binding]; other site 266835007879 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266835007880 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 266835007881 metal binding site [ion binding]; metal-binding site 266835007882 active site 266835007883 I-site; other site 266835007884 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4944 266835007885 RNA polymerase sigma factor; Provisional; Region: PRK12512 266835007886 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 266835007887 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 266835007888 DNA binding residues [nucleotide binding] 266835007889 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 266835007890 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 266835007891 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 266835007892 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835007893 dimer interface [polypeptide binding]; other site 266835007894 conserved gate region; other site 266835007895 putative PBP binding loops; other site 266835007896 ABC-ATPase subunit interface; other site 266835007897 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835007898 dimer interface [polypeptide binding]; other site 266835007899 conserved gate region; other site 266835007900 putative PBP binding loops; other site 266835007901 ABC-ATPase subunit interface; other site 266835007902 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 266835007903 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 266835007904 Walker A/P-loop; other site 266835007905 ATP binding site [chemical binding]; other site 266835007906 Q-loop/lid; other site 266835007907 ABC transporter signature motif; other site 266835007908 Walker B; other site 266835007909 D-loop; other site 266835007910 H-loop/switch region; other site 266835007911 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 266835007912 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 266835007913 Walker A/P-loop; other site 266835007914 ATP binding site [chemical binding]; other site 266835007915 Q-loop/lid; other site 266835007916 ABC transporter signature motif; other site 266835007917 Walker B; other site 266835007918 D-loop; other site 266835007919 H-loop/switch region; other site 266835007920 TOBE domain; Region: TOBE_2; pfam08402 266835007921 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 266835007922 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835007923 dimer interface [polypeptide binding]; other site 266835007924 conserved gate region; other site 266835007925 putative PBP binding loops; other site 266835007926 ABC-ATPase subunit interface; other site 266835007927 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835007928 dimer interface [polypeptide binding]; other site 266835007929 conserved gate region; other site 266835007930 putative PBP binding loops; other site 266835007931 ABC-ATPase subunit interface; other site 266835007932 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 266835007933 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 266835007934 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 266835007935 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 266835007936 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 266835007937 PAS domain S-box; Region: sensory_box; TIGR00229 266835007938 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 266835007939 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266835007940 metal binding site [ion binding]; metal-binding site 266835007941 active site 266835007942 I-site; other site 266835007943 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 266835007944 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 266835007945 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 266835007946 catalytic residues [active] 266835007947 argininosuccinate lyase; Provisional; Region: PRK00855 266835007948 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 266835007949 active sites [active] 266835007950 tetramer interface [polypeptide binding]; other site 266835007951 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 266835007952 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 266835007953 active site 266835007954 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 266835007955 substrate binding site [chemical binding]; other site 266835007956 catalytic residues [active] 266835007957 dimer interface [polypeptide binding]; other site 266835007958 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266835007959 dimerization interface [polypeptide binding]; other site 266835007960 putative DNA binding site [nucleotide binding]; other site 266835007961 putative Zn2+ binding site [ion binding]; other site 266835007962 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 266835007963 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 266835007964 tetramer interface [polypeptide binding]; other site 266835007965 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266835007966 catalytic residue [active] 266835007967 Domain of unknown function (DUF4175); Region: DUF4175; pfam13779 266835007968 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 266835007969 ligand binding site [chemical binding]; other site 266835007970 dimer interface [polypeptide binding]; other site 266835007971 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266835007972 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266835007973 dimerization interface [polypeptide binding]; other site 266835007974 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 266835007975 EamA-like transporter family; Region: EamA; pfam00892 266835007976 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 266835007977 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266835007978 active site 266835007979 phosphorylation site [posttranslational modification] 266835007980 intermolecular recognition site; other site 266835007981 dimerization interface [polypeptide binding]; other site 266835007982 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 266835007983 active site 266835007984 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 266835007985 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 266835007986 Walker A/P-loop; other site 266835007987 ATP binding site [chemical binding]; other site 266835007988 Q-loop/lid; other site 266835007989 ABC transporter signature motif; other site 266835007990 Walker B; other site 266835007991 D-loop; other site 266835007992 H-loop/switch region; other site 266835007993 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 266835007994 Uncharacterized conserved protein [Function unknown]; Region: COG1434 266835007995 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 266835007996 putative active site [active] 266835007997 Predicted flavin-nucleotide-binding protein structurally related to pyridoxine 5'-phosphate oxidase [General function prediction only]; Region: COG3576 266835007998 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3558 266835007999 SnoaL-like domain; Region: SnoaL_2; pfam12680 266835008000 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266835008001 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_2; cd08471 266835008002 putative effector binding pocket; other site 266835008003 putative dimerization interface [polypeptide binding]; other site 266835008004 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 266835008005 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 266835008006 putative acyl-acceptor binding pocket; other site 266835008007 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 266835008008 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 266835008009 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 266835008010 active site 266835008011 catalytic tetrad [active] 266835008012 Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703 266835008013 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 266835008014 putative active site pocket [active] 266835008015 dimerization interface [polypeptide binding]; other site 266835008016 putative catalytic residue [active] 266835008017 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4093 266835008018 Uncharacterized protein conserved in bacteria (DUF2125); Region: DUF2125; pfam09898 266835008019 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 266835008020 Ribokinase-like subgroup B. Found in bacteria and plants, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_B; cd01945 266835008021 substrate binding site [chemical binding]; other site 266835008022 ATP binding site [chemical binding]; other site 266835008023 cyclohexadienyl dehydrogenase; Validated; Region: PRK07502 266835008024 prephenate dehydrogenase; Validated; Region: PRK08507 266835008025 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 266835008026 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 266835008027 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266835008028 homodimer interface [polypeptide binding]; other site 266835008029 catalytic residue [active] 266835008030 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 266835008031 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 266835008032 Methyltransferase domain; Region: Methyltransf_23; pfam13489 266835008033 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266835008034 S-adenosylmethionine binding site [chemical binding]; other site 266835008035 Macro domain, Poa1p_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Poa1p_like; cd02901 266835008036 ADP-ribose binding site [chemical binding]; other site 266835008037 Uncharacterized conserved protein [Function unknown]; Region: COG5470 266835008038 Protein of unknown function (DUF1194); Region: DUF1194; pfam06707 266835008039 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 266835008040 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 266835008041 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 266835008042 Methyltransferase domain; Region: Methyltransf_23; pfam13489 266835008043 Methyltransferase domain; Region: Methyltransf_11; pfam08241 266835008044 hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413 266835008045 Uncharacterized conserved protein [Function unknown]; Region: COG3542 266835008046 Predicted membrane protein [Function unknown]; Region: COG3714 266835008047 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 266835008048 EamA-like transporter family; Region: EamA; pfam00892 266835008049 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 266835008050 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 266835008051 Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738 266835008052 Spermidine synthase [Amino acid transport and metabolism]; Region: SpeE; COG0421 266835008053 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 266835008054 Gag P30 core shell protein; Region: Gag_p30; pfam02093 266835008055 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266835008056 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266835008057 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 266835008058 putative effector binding pocket; other site 266835008059 dimerization interface [polypeptide binding]; other site 266835008060 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_7; cd08900 266835008061 putative hydrophobic ligand binding site [chemical binding]; other site 266835008062 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266835008063 dimerization interface [polypeptide binding]; other site 266835008064 putative DNA binding site [nucleotide binding]; other site 266835008065 putative Zn2+ binding site [ion binding]; other site 266835008066 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4246 266835008067 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 266835008068 Cobalamin biosynthesis protein CobT; Region: CobT; pfam06213 266835008069 cobaltochelatase, CobT subunit; Region: CobT; TIGR01651 266835008070 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 266835008071 metal ion-dependent adhesion site (MIDAS); other site 266835008072 cobaltochelatase, CobS subunit; Region: PD_CobS; TIGR01650 266835008073 Cobaltochelatase CobS subunit N terminal; Region: CobS_N; pfam12556 266835008074 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 266835008075 DnaJ-class molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: CbpA; COG2214 266835008076 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 266835008077 HSP70 interaction site [polypeptide binding]; other site 266835008078 Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271 266835008079 hypothetical protein; Validated; Region: PRK07586 266835008080 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 266835008081 PYR/PP interface [polypeptide binding]; other site 266835008082 dimer interface [polypeptide binding]; other site 266835008083 TPP binding site [chemical binding]; other site 266835008084 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 266835008085 TPP-binding site [chemical binding]; other site 266835008086 dimer interface [polypeptide binding]; other site 266835008087 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 266835008088 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 266835008089 FOG: CBS domain [General function prediction only]; Region: COG0517 266835008090 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 266835008091 Transporter associated domain; Region: CorC_HlyC; smart01091 266835008092 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 266835008093 active site 266835008094 dimer interface [polypeptide binding]; other site 266835008095 metal binding site [ion binding]; metal-binding site 266835008096 shikimate kinase; Provisional; Region: PRK13946 266835008097 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 266835008098 ADP binding site [chemical binding]; other site 266835008099 magnesium binding site [ion binding]; other site 266835008100 putative shikimate binding site; other site 266835008101 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 266835008102 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 266835008103 active site 266835008104 DNA binding site [nucleotide binding] 266835008105 Int/Topo IB signature motif; other site 266835008106 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 266835008107 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 266835008108 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 266835008109 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 266835008110 CPxP motif; other site 266835008111 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 266835008112 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 266835008113 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 266835008114 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 266835008115 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 266835008116 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 266835008117 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 266835008118 metal binding site [ion binding]; metal-binding site 266835008119 putative dimer interface [polypeptide binding]; other site 266835008120 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 266835008121 Predicted membrane protein [Function unknown]; Region: COG1238 266835008122 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 266835008123 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 266835008124 Multicopper oxidase; Region: Cu-oxidase; pfam00394 266835008125 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 266835008126 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 266835008127 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266835008128 Walker A/P-loop; other site 266835008129 ATP binding site [chemical binding]; other site 266835008130 Q-loop/lid; other site 266835008131 ABC transporter signature motif; other site 266835008132 Walker B; other site 266835008133 D-loop; other site 266835008134 H-loop/switch region; other site 266835008135 TOBE domain; Region: TOBE_2; pfam08402 266835008136 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 266835008137 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835008138 dimer interface [polypeptide binding]; other site 266835008139 conserved gate region; other site 266835008140 putative PBP binding loops; other site 266835008141 ABC-ATPase subunit interface; other site 266835008142 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835008143 dimer interface [polypeptide binding]; other site 266835008144 conserved gate region; other site 266835008145 putative PBP binding loops; other site 266835008146 ABC-ATPase subunit interface; other site 266835008147 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 266835008148 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 266835008149 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 266835008150 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 266835008151 Predicted transcriptional regulator [Transcription]; Region: COG4189 266835008152 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266835008153 dimerization interface [polypeptide binding]; other site 266835008154 putative DNA binding site [nucleotide binding]; other site 266835008155 putative Zn2+ binding site [ion binding]; other site 266835008156 Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450 266835008157 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 266835008158 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_11; cd06321 266835008159 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 266835008160 putative ligand binding site [chemical binding]; other site 266835008161 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 266835008162 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 266835008163 TM-ABC transporter signature motif; other site 266835008164 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 266835008165 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 266835008166 Walker A/P-loop; other site 266835008167 ATP binding site [chemical binding]; other site 266835008168 Q-loop/lid; other site 266835008169 ABC transporter signature motif; other site 266835008170 Walker B; other site 266835008171 D-loop; other site 266835008172 H-loop/switch region; other site 266835008173 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 266835008174 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 266835008175 Novosphingobium aromaticivorans carbohydrate kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_NaCK_like; cd07772 266835008176 N- and C-terminal domain interface [polypeptide binding]; other site 266835008177 putative active site [active] 266835008178 putative MgATP binding site [chemical binding]; other site 266835008179 putative catalytic site [active] 266835008180 metal binding site [ion binding]; metal-binding site 266835008181 putative carbohydrate binding site [chemical binding]; other site 266835008182 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266835008183 putative DNA binding site [nucleotide binding]; other site 266835008184 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 266835008185 putative Zn2+ binding site [ion binding]; other site 266835008186 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 266835008187 Uncharacterized conserved protein [Function unknown]; Region: COG3347 266835008188 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596 266835008189 intersubunit interface [polypeptide binding]; other site 266835008190 active site 266835008191 Zn2+ binding site [ion binding]; other site 266835008192 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 266835008193 D-xylulose kinase; Region: XylB; TIGR01312 266835008194 nucleotide binding site [chemical binding]; other site 266835008195 HAD-superfamily class IIA hydrolase, TIGR01459; Region: HAD-SF-IIA-hyp4 266835008196 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 266835008197 active site 266835008198 motif I; other site 266835008199 motif II; other site 266835008200 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 266835008201 motif II; other site 266835008202 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 266835008203 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 266835008204 DNA binding residues [nucleotide binding] 266835008205 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 266835008206 Uncharacterized conserved protein [Function unknown]; Region: COG3791 266835008207 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 266835008208 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 266835008209 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 266835008210 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 266835008211 Phosphotransferase system sorbitol-specific component IIA [Carbohydrate transport and metabolism]; Region: SrlB; COG3731 266835008212 Phosphotransferase system sorbitol-specific component IIBC [Carbohydrate transport and metabolism]; Region: SrlE; COG3732 266835008213 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 266835008214 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 266835008215 Phosphotransferase system sorbitol-specific component IIC [Carbohydrate transport and metabolism]; Region: SrlA; COG3730 266835008216 Glucitol operon activator [Transcription]; Region: GutM; COG4578 266835008217 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 266835008218 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 266835008219 active site 266835008220 motif I; other site 266835008221 motif II; other site 266835008222 Domain of Unknown Function (DUF930); Region: DUF930; pfam06059 266835008223 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 266835008224 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 266835008225 Domain of Unknown Function (DUF930); Region: DUF930; pfam06059 266835008226 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 266835008227 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266835008228 Walker A/P-loop; other site 266835008229 ATP binding site [chemical binding]; other site 266835008230 Q-loop/lid; other site 266835008231 ABC transporter signature motif; other site 266835008232 Walker B; other site 266835008233 D-loop; other site 266835008234 H-loop/switch region; other site 266835008235 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 266835008236 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835008237 dimer interface [polypeptide binding]; other site 266835008238 conserved gate region; other site 266835008239 putative PBP binding loops; other site 266835008240 ABC-ATPase subunit interface; other site 266835008241 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835008242 dimer interface [polypeptide binding]; other site 266835008243 conserved gate region; other site 266835008244 putative PBP binding loops; other site 266835008245 ABC-ATPase subunit interface; other site 266835008246 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 266835008247 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 266835008248 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 266835008249 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 266835008250 E3 interaction surface; other site 266835008251 lipoyl attachment site [posttranslational modification]; other site 266835008252 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 266835008253 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 266835008254 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 266835008255 alpha subunit interface [polypeptide binding]; other site 266835008256 TPP binding site [chemical binding]; other site 266835008257 heterodimer interface [polypeptide binding]; other site 266835008258 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 266835008259 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 266835008260 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 266835008261 tetramer interface [polypeptide binding]; other site 266835008262 TPP-binding site [chemical binding]; other site 266835008263 heterodimer interface [polypeptide binding]; other site 266835008264 phosphorylation loop region [posttranslational modification] 266835008265 Predicted homoserine dehydrogenase [Amino acid transport and metabolism]; Region: COG4091 266835008266 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 266835008267 SAF domain of putative dehydrogenases or oxidoreductases; Region: SAF_DH_OX_like; cd11616 266835008268 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 266835008269 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 266835008270 active site 266835008271 metal binding site [ion binding]; metal-binding site 266835008272 hexamer interface [polypeptide binding]; other site 266835008273 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 266835008274 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835008275 NAD(P) binding site [chemical binding]; other site 266835008276 active site 266835008277 acetoacetate decarboxylase; Provisional; Region: PRK02265 266835008278 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 266835008279 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 266835008280 nucleophile elbow; other site 266835008281 Patatin phospholipase; Region: DUF3734; pfam12536 266835008282 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 266835008283 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 266835008284 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 266835008285 non-specific DNA interactions [nucleotide binding]; other site 266835008286 DNA binding site [nucleotide binding] 266835008287 sequence specific DNA binding site [nucleotide binding]; other site 266835008288 putative cAMP binding site [chemical binding]; other site 266835008289 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 266835008290 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 266835008291 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 266835008292 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 266835008293 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835008294 dimer interface [polypeptide binding]; other site 266835008295 conserved gate region; other site 266835008296 putative PBP binding loops; other site 266835008297 ABC-ATPase subunit interface; other site 266835008298 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 266835008299 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835008300 dimer interface [polypeptide binding]; other site 266835008301 conserved gate region; other site 266835008302 putative PBP binding loops; other site 266835008303 ABC-ATPase subunit interface; other site 266835008304 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 266835008305 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 266835008306 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 266835008307 dimer interface [polypeptide binding]; other site 266835008308 active site 266835008309 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 266835008310 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 266835008311 substrate binding site [chemical binding]; other site 266835008312 ATP binding site [chemical binding]; other site 266835008313 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 266835008314 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 266835008315 Walker A/P-loop; other site 266835008316 ATP binding site [chemical binding]; other site 266835008317 Q-loop/lid; other site 266835008318 ABC transporter signature motif; other site 266835008319 Walker B; other site 266835008320 D-loop; other site 266835008321 H-loop/switch region; other site 266835008322 TOBE domain; Region: TOBE_2; pfam08402 266835008323 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266835008324 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266835008325 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 266835008326 HlyD family secretion protein; Region: HlyD_3; pfam13437 266835008327 multidrug efflux protein; Reviewed; Region: PRK09579 266835008328 Protein export membrane protein; Region: SecD_SecF; cl14618 266835008329 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 266835008330 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 266835008331 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 266835008332 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266835008333 DNA binding site [nucleotide binding] 266835008334 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 266835008335 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266835008336 active site 266835008337 phosphorylation site [posttranslational modification] 266835008338 intermolecular recognition site; other site 266835008339 dimerization interface [polypeptide binding]; other site 266835008340 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266835008341 DNA binding site [nucleotide binding] 266835008342 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 266835008343 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 266835008344 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 266835008345 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266835008346 putative active site [active] 266835008347 heme pocket [chemical binding]; other site 266835008348 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266835008349 dimer interface [polypeptide binding]; other site 266835008350 phosphorylation site [posttranslational modification] 266835008351 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266835008352 ATP binding site [chemical binding]; other site 266835008353 Mg2+ binding site [ion binding]; other site 266835008354 G-X-G motif; other site 266835008355 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266835008356 active site 266835008357 phosphorylation site [posttranslational modification] 266835008358 intermolecular recognition site; other site 266835008359 dimerization interface [polypeptide binding]; other site 266835008360 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 266835008361 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 266835008362 [2Fe-2S] cluster binding site [ion binding]; other site 266835008363 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 266835008364 alpha subunit interface [polypeptide binding]; other site 266835008365 active site 266835008366 substrate binding site [chemical binding]; other site 266835008367 Fe binding site [ion binding]; other site 266835008368 hypothetical protein; Provisional; Region: PRK07036 266835008369 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 266835008370 inhibitor-cofactor binding pocket; inhibition site 266835008371 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266835008372 catalytic residue [active] 266835008373 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835008374 dimer interface [polypeptide binding]; other site 266835008375 conserved gate region; other site 266835008376 putative PBP binding loops; other site 266835008377 ABC-ATPase subunit interface; other site 266835008378 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 266835008379 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835008380 dimer interface [polypeptide binding]; other site 266835008381 conserved gate region; other site 266835008382 putative PBP binding loops; other site 266835008383 ABC-ATPase subunit interface; other site 266835008384 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 266835008385 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 266835008386 Walker A/P-loop; other site 266835008387 ATP binding site [chemical binding]; other site 266835008388 Q-loop/lid; other site 266835008389 ABC transporter signature motif; other site 266835008390 Walker B; other site 266835008391 D-loop; other site 266835008392 H-loop/switch region; other site 266835008393 TOBE domain; Region: TOBE_2; pfam08402 266835008394 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 266835008395 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 266835008396 hydroxyglutarate oxidase; Provisional; Region: PRK11728 266835008397 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 266835008398 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 266835008399 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 266835008400 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 266835008401 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266835008402 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 266835008403 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266835008404 S-adenosylmethionine binding site [chemical binding]; other site 266835008405 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 266835008406 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 266835008407 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 266835008408 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 266835008409 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 266835008410 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 266835008411 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 266835008412 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 266835008413 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 266835008414 active site 266835008415 dimer interface [polypeptide binding]; other site 266835008416 Predicted acetyltransferase [General function prediction only]; Region: COG2388 266835008417 Predicted esterase [General function prediction only]; Region: COG0400 266835008418 putative hydrolase; Provisional; Region: PRK11460 266835008419 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 266835008420 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266835008421 Zn binding site [ion binding]; other site 266835008422 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 266835008423 Zn binding site [ion binding]; other site 266835008424 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 266835008425 Sulfatase; Region: Sulfatase; cl17466 266835008426 PRC-barrel domain; Region: PRC; pfam05239 266835008427 PRC-barrel domain; Region: PRC; pfam05239 266835008428 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 266835008429 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 266835008430 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 266835008431 GAF domain; Region: GAF; pfam01590 266835008432 PAS fold; Region: PAS_3; pfam08447 266835008433 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 266835008434 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 266835008435 HWE histidine kinase; Region: HWE_HK; pfam07536 266835008436 Bacterial protein of unknown function (DUF883); Region: DUF883; pfam05957 266835008437 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 266835008438 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 266835008439 ligand binding site [chemical binding]; other site 266835008440 flexible hinge region; other site 266835008441 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 266835008442 putative switch regulator; other site 266835008443 non-specific DNA interactions [nucleotide binding]; other site 266835008444 DNA binding site [nucleotide binding] 266835008445 sequence specific DNA binding site [nucleotide binding]; other site 266835008446 putative cAMP binding site [chemical binding]; other site 266835008447 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 266835008448 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266835008449 active site 266835008450 phosphorylation site [posttranslational modification] 266835008451 intermolecular recognition site; other site 266835008452 dimerization interface [polypeptide binding]; other site 266835008453 RNA polymerase sigma factor; Provisional; Region: PRK12547 266835008454 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 266835008455 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 266835008456 DNA binding residues [nucleotide binding] 266835008457 two-component response regulator; Provisional; Region: PRK09191 266835008458 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266835008459 active site 266835008460 phosphorylation site [posttranslational modification] 266835008461 intermolecular recognition site; other site 266835008462 dimerization interface [polypeptide binding]; other site 266835008463 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 266835008464 HWE histidine kinase; Region: HWE_HK; pfam07536 266835008465 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3614 266835008466 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 266835008467 HWE histidine kinase; Region: HWE_HK; pfam07536 266835008468 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 266835008469 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266835008470 Walker A/P-loop; other site 266835008471 ATP binding site [chemical binding]; other site 266835008472 Q-loop/lid; other site 266835008473 ABC transporter signature motif; other site 266835008474 Walker B; other site 266835008475 D-loop; other site 266835008476 H-loop/switch region; other site 266835008477 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 266835008478 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 266835008479 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 266835008480 TM-ABC transporter signature motif; other site 266835008481 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 266835008482 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 266835008483 putative ligand binding site [chemical binding]; other site 266835008484 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 266835008485 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 266835008486 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 266835008487 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266835008488 active site 266835008489 phosphorylation site [posttranslational modification] 266835008490 intermolecular recognition site; other site 266835008491 dimerization interface [polypeptide binding]; other site 266835008492 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266835008493 DNA binding site [nucleotide binding] 266835008494 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 266835008495 PhoU domain; Region: PhoU; pfam01895 266835008496 PhoU domain; Region: PhoU; pfam01895 266835008497 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 266835008498 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 266835008499 Walker A/P-loop; other site 266835008500 ATP binding site [chemical binding]; other site 266835008501 Q-loop/lid; other site 266835008502 ABC transporter signature motif; other site 266835008503 Walker B; other site 266835008504 D-loop; other site 266835008505 H-loop/switch region; other site 266835008506 phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268 266835008507 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835008508 dimer interface [polypeptide binding]; other site 266835008509 conserved gate region; other site 266835008510 putative PBP binding loops; other site 266835008511 ABC-ATPase subunit interface; other site 266835008512 phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275 266835008513 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835008514 dimer interface [polypeptide binding]; other site 266835008515 conserved gate region; other site 266835008516 putative PBP binding loops; other site 266835008517 ABC-ATPase subunit interface; other site 266835008518 PBP superfamily domain; Region: PBP_like_2; cl17296 266835008519 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266835008520 PAS domain; Region: PAS_9; pfam13426 266835008521 putative active site [active] 266835008522 heme pocket [chemical binding]; other site 266835008523 PAS fold; Region: PAS_7; pfam12860 266835008524 PAS fold; Region: PAS_7; pfam12860 266835008525 PAS fold; Region: PAS_7; pfam12860 266835008526 PAS fold; Region: PAS_4; pfam08448 266835008527 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266835008528 putative active site [active] 266835008529 heme pocket [chemical binding]; other site 266835008530 PAS domain S-box; Region: sensory_box; TIGR00229 266835008531 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266835008532 putative active site [active] 266835008533 heme pocket [chemical binding]; other site 266835008534 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 266835008535 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266835008536 dimer interface [polypeptide binding]; other site 266835008537 phosphorylation site [posttranslational modification] 266835008538 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266835008539 ATP binding site [chemical binding]; other site 266835008540 Mg2+ binding site [ion binding]; other site 266835008541 G-X-G motif; other site 266835008542 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 266835008543 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266835008544 active site 266835008545 phosphorylation site [posttranslational modification] 266835008546 intermolecular recognition site; other site 266835008547 dimerization interface [polypeptide binding]; other site 266835008548 Response regulator receiver domain; Region: Response_reg; pfam00072 266835008549 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266835008550 active site 266835008551 phosphorylation site [posttranslational modification] 266835008552 intermolecular recognition site; other site 266835008553 dimerization interface [polypeptide binding]; other site 266835008554 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 266835008555 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 266835008556 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 266835008557 N-terminal domain interface [polypeptide binding]; other site 266835008558 dimer interface [polypeptide binding]; other site 266835008559 substrate binding pocket (H-site) [chemical binding]; other site 266835008560 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 266835008561 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266835008562 Zn binding site [ion binding]; other site 266835008563 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266835008564 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 266835008565 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 266835008566 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 266835008567 RNA binding surface [nucleotide binding]; other site 266835008568 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 266835008569 active site 266835008570 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 266835008571 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 266835008572 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 266835008573 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 266835008574 DNA binding residues [nucleotide binding] 266835008575 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 266835008576 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 266835008577 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 266835008578 dimer interface [polypeptide binding]; other site 266835008579 decamer (pentamer of dimers) interface [polypeptide binding]; other site 266835008580 catalytic triad [active] 266835008581 Cell division protein ZapA (stimulator of FtsZ polymerization and Z-ring component) [Cell cycle control, cell division, chromosome partitioning]; Region: zapA; COG3027 266835008582 Domain of unknown function (DUF4164); Region: DUF4164; pfam13747 266835008583 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 266835008584 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 266835008585 TPP-binding site [chemical binding]; other site 266835008586 dimer interface [polypeptide binding]; other site 266835008587 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 266835008588 PYR/PP interface [polypeptide binding]; other site 266835008589 dimer interface [polypeptide binding]; other site 266835008590 TPP binding site [chemical binding]; other site 266835008591 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 266835008592 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 266835008593 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 266835008594 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 266835008595 NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain [Inorganic ion transport and metabolism]; Region: COG3263 266835008596 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 266835008597 Phosphoglycerate kinase; Region: PGK; pfam00162 266835008598 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 266835008599 substrate binding site [chemical binding]; other site 266835008600 hinge regions; other site 266835008601 ADP binding site [chemical binding]; other site 266835008602 catalytic site [active] 266835008603 Fructose-1,6-bisphosphate aldolase; Region: FBP_aldolase_I_a; cd00948 266835008604 active site 266835008605 intersubunit interface [polypeptide binding]; other site 266835008606 catalytic residue [active] 266835008607 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4312 266835008608 SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836 266835008609 active site 266835008610 catalytic triad [active] 266835008611 oxyanion hole [active] 266835008612 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 266835008613 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266835008614 Zn binding site [ion binding]; other site 266835008615 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 266835008616 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266835008617 Zn binding site [ion binding]; other site 266835008618 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_3; cd03140 266835008619 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 266835008620 conserved cys residue [active] 266835008621 Predicted transcriptional regulator [Transcription]; Region: COG2378 266835008622 HTH domain; Region: HTH_11; pfam08279 266835008623 WYL domain; Region: WYL; pfam13280 266835008624 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3820 266835008625 Uncharacterized conserved small protein [Function unknown]; Region: COG5457 266835008626 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 266835008627 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 266835008628 NAD(P) binding site [chemical binding]; other site 266835008629 Uncharacterized small protein containing a coiled-coil domain [Function unknown]; Region: COG5509 266835008630 putative MFS family transporter protein; Provisional; Region: PRK03633 266835008631 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266835008632 putative substrate translocation pore; other site 266835008633 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266835008634 dimerization interface [polypeptide binding]; other site 266835008635 putative DNA binding site [nucleotide binding]; other site 266835008636 putative Zn2+ binding site [ion binding]; other site 266835008637 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_7; cd08900 266835008638 putative hydrophobic ligand binding site [chemical binding]; other site 266835008639 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266835008640 dimerization interface [polypeptide binding]; other site 266835008641 putative DNA binding site [nucleotide binding]; other site 266835008642 putative Zn2+ binding site [ion binding]; other site 266835008643 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 266835008644 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 266835008645 C-terminal domain interface [polypeptide binding]; other site 266835008646 GSH binding site (G-site) [chemical binding]; other site 266835008647 dimer interface [polypeptide binding]; other site 266835008648 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 266835008649 N-terminal domain interface [polypeptide binding]; other site 266835008650 dimer interface [polypeptide binding]; other site 266835008651 substrate binding pocket (H-site) [chemical binding]; other site 266835008652 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 266835008653 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 266835008654 TAP-like protein; Region: Abhydrolase_4; pfam08386 266835008655 Predicted transcriptional regulators [Transcription]; Region: COG1733 266835008656 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 266835008657 Uncharacterized protein, possibly involved in utilization of glycolate and propanediol [General function prediction only]; Region: GlcG; COG3193 266835008658 Ribosomal protein L32 [Translation, ribosomal structure and biogenesis]; Region: RpmF; COG0333 266835008659 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 266835008660 Transglycosylase; Region: Transgly; pfam00912 266835008661 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 266835008662 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 266835008663 substrate binding pocket [chemical binding]; other site 266835008664 aspartate-rich region 1; other site 266835008665 gluconate 5-dehydrogenase; Provisional; Region: PRK07523 266835008666 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 266835008667 NADP binding site [chemical binding]; other site 266835008668 homodimer interface [polypeptide binding]; other site 266835008669 active site 266835008670 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 266835008671 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266835008672 dimer interface [polypeptide binding]; other site 266835008673 phosphorylation site [posttranslational modification] 266835008674 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266835008675 ATP binding site [chemical binding]; other site 266835008676 Mg2+ binding site [ion binding]; other site 266835008677 G-X-G motif; other site 266835008678 Response regulator receiver domain; Region: Response_reg; pfam00072 266835008679 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266835008680 active site 266835008681 phosphorylation site [posttranslational modification] 266835008682 intermolecular recognition site; other site 266835008683 dimerization interface [polypeptide binding]; other site 266835008684 Response regulator receiver domain; Region: Response_reg; pfam00072 266835008685 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266835008686 active site 266835008687 phosphorylation site [posttranslational modification] 266835008688 intermolecular recognition site; other site 266835008689 dimerization interface [polypeptide binding]; other site 266835008690 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 266835008691 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266835008692 S-adenosylmethionine binding site [chemical binding]; other site 266835008693 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4424 266835008694 Chloramphenicol (Cm) phosphotransferase (CPT). Cm-inactivating enzyme; modifies the primary (C-3) hydroxyl of the antibiotic. Related structurally to shikimate kinase II; Region: CPT; cd00227 266835008695 P-loop motif; other site 266835008696 ATP binding site [chemical binding]; other site 266835008697 Chloramphenicol (Cm) binding site [chemical binding]; other site 266835008698 catalytic residue [active] 266835008699 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 266835008700 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 266835008701 N-acetyl-D-glucosamine binding site [chemical binding]; other site 266835008702 catalytic residue [active] 266835008703 Sporulation related domain; Region: SPOR; pfam05036 266835008704 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 266835008705 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 266835008706 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 266835008707 Uncharacterized small protein [Function unknown]; Region: COG5570 266835008708 Uncharacterized conserved small protein containing a coiled-coil domain [Function unknown]; Region: COG5481 266835008709 Transcriptional regulator [Transcription]; Region: IclR; COG1414 266835008710 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266835008711 putative DNA binding site [nucleotide binding]; other site 266835008712 putative Zn2+ binding site [ion binding]; other site 266835008713 Bacterial transcriptional regulator; Region: IclR; pfam01614 266835008714 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 266835008715 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 266835008716 substrate binding pocket [chemical binding]; other site 266835008717 membrane-bound complex binding site; other site 266835008718 hinge residues; other site 266835008719 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835008720 dimer interface [polypeptide binding]; other site 266835008721 conserved gate region; other site 266835008722 putative PBP binding loops; other site 266835008723 ABC-ATPase subunit interface; other site 266835008724 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835008725 dimer interface [polypeptide binding]; other site 266835008726 conserved gate region; other site 266835008727 putative PBP binding loops; other site 266835008728 ABC-ATPase subunit interface; other site 266835008729 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 266835008730 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 266835008731 Walker A/P-loop; other site 266835008732 ATP binding site [chemical binding]; other site 266835008733 Q-loop/lid; other site 266835008734 ABC transporter signature motif; other site 266835008735 Walker B; other site 266835008736 D-loop; other site 266835008737 H-loop/switch region; other site 266835008738 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 266835008739 homotrimer interaction site [polypeptide binding]; other site 266835008740 putative active site [active] 266835008741 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 266835008742 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 266835008743 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 266835008744 catalytic residue [active] 266835008745 catalytic residue [active] 266835008746 RNA polymerase sigma factor; Provisional; Region: PRK11924 266835008747 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 266835008748 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 266835008749 DNA binding residues [nucleotide binding] 266835008750 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 266835008751 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 266835008752 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 266835008753 ATP-grasp domain; Region: ATP-grasp; pfam02222 266835008754 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3755 266835008755 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 266835008756 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266835008757 binding surface 266835008758 TPR motif; other site 266835008759 TPR repeat; Region: TPR_11; pfam13414 266835008760 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 266835008761 pyruvate kinase; Provisional; Region: PRK06247 266835008762 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 266835008763 domain interfaces; other site 266835008764 active site 266835008765 Predicted integral membrane protein [Function unknown]; Region: COG5480 266835008766 Predicted N-formylglutamate amidohydrolase [Amino acid transport and metabolism]; Region: COG3931 266835008767 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3492 266835008768 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 266835008769 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266835008770 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266835008771 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266835008772 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266835008773 dimerization interface [polypeptide binding]; other site 266835008774 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 266835008775 atypical (a) SDRs, subgroup 3; Region: SDR_a3; cd05229 266835008776 putative NAD(P) binding site [chemical binding]; other site 266835008777 putative active site [active] 266835008778 Protein of unknown function (DUF3309); Region: DUF3309; pfam11752 266835008779 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 266835008780 Protein export membrane protein; Region: SecD_SecF; cl14618 266835008781 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 266835008782 HlyD family secretion protein; Region: HlyD_3; pfam13437 266835008783 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 266835008784 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 266835008785 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 266835008786 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 266835008787 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 266835008788 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 266835008789 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 266835008790 catalytic loop [active] 266835008791 iron binding site [ion binding]; other site 266835008792 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 266835008793 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266835008794 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 266835008795 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 266835008796 active site 266835008797 nucleophile elbow; other site 266835008798 Bacillus subtilis (Bs) citrate synthase CS-I_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BsCS-I_like; cd06109 266835008799 dimer interface [polypeptide binding]; other site 266835008800 Citrate synthase; Region: Citrate_synt; pfam00285 266835008801 active site 266835008802 citrylCoA binding site [chemical binding]; other site 266835008803 oxalacetate/citrate binding site [chemical binding]; other site 266835008804 coenzyme A binding site [chemical binding]; other site 266835008805 catalytic triad [active] 266835008806 Helix-turn-helix domain; Region: HTH_17; pfam12728 266835008807 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 266835008808 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 266835008809 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_2; cd06102 266835008810 dimer interface [polypeptide binding]; other site 266835008811 active site 266835008812 oxalacetate/citrate binding site [chemical binding]; other site 266835008813 citrylCoA binding site [chemical binding]; other site 266835008814 coenzyme A binding site [chemical binding]; other site 266835008815 catalytic triad [active] 266835008816 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 266835008817 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 266835008818 conserved cys residue [active] 266835008819 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266835008820 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266835008821 Member of the Rhodanese Homology Domain superfamily. This CD includes the putative rhodanese-like protein, Psp2, of Yersinia pestis biovar Medievalis and other similar uncharacterized proteins; Region: RHOD_PspE2; cd01521 266835008822 active site residue [active] 266835008823 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5394 266835008824 PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879 266835008825 PHB accumulation regulatory domain; Region: PHB_acc; pfam05233 266835008826 putative acyltransferase; Provisional; Region: PRK05790 266835008827 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 266835008828 dimer interface [polypeptide binding]; other site 266835008829 active site 266835008830 acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829 266835008831 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 266835008832 NAD(P) binding site [chemical binding]; other site 266835008833 homotetramer interface [polypeptide binding]; other site 266835008834 homodimer interface [polypeptide binding]; other site 266835008835 active site 266835008836 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 266835008837 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 266835008838 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 266835008839 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266835008840 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266835008841 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 266835008842 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 266835008843 nucleotide binding region [chemical binding]; other site 266835008844 ATP-binding site [chemical binding]; other site 266835008845 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 266835008846 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 266835008847 RNA binding surface [nucleotide binding]; other site 266835008848 Ferredoxin [Energy production and conversion]; Region: COG1146 266835008849 4Fe-4S binding domain; Region: Fer4; pfam00037 266835008850 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 266835008851 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 266835008852 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 266835008853 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 266835008854 Walker A/P-loop; other site 266835008855 ATP binding site [chemical binding]; other site 266835008856 Q-loop/lid; other site 266835008857 ABC transporter signature motif; other site 266835008858 Walker B; other site 266835008859 D-loop; other site 266835008860 H-loop/switch region; other site 266835008861 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 266835008862 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835008863 dimer interface [polypeptide binding]; other site 266835008864 conserved gate region; other site 266835008865 putative PBP binding loops; other site 266835008866 ABC-ATPase subunit interface; other site 266835008867 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 266835008868 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 266835008869 substrate binding pocket [chemical binding]; other site 266835008870 membrane-bound complex binding site; other site 266835008871 hinge residues; other site 266835008872 RNA polymerase factor sigma-32; Reviewed; Region: rpoH2; PRK07500 266835008873 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 266835008874 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 266835008875 DNA binding residues [nucleotide binding] 266835008876 Putative Zn-dependent protease [General function prediction only]; Region: COG4784 266835008877 Peptidase family M48; Region: Peptidase_M48; pfam01435 266835008878 ABC-type thiamine transport system, ATPase component [Coenzyme metabolism]; Region: ThiQ; COG3840 266835008879 ATP-binding cassette domain of the thiamine transport system; Region: ABC_ThiQ_thiamine_transporter; cd03298 266835008880 Walker A/P-loop; other site 266835008881 ATP binding site [chemical binding]; other site 266835008882 Q-loop/lid; other site 266835008883 ABC transporter signature motif; other site 266835008884 Walker B; other site 266835008885 D-loop; other site 266835008886 H-loop/switch region; other site 266835008887 thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433 266835008888 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835008889 dimer interface [polypeptide binding]; other site 266835008890 conserved gate region; other site 266835008891 putative PBP binding loops; other site 266835008892 ABC-ATPase subunit interface; other site 266835008893 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835008894 dimer interface [polypeptide binding]; other site 266835008895 conserved gate region; other site 266835008896 putative PBP binding loops; other site 266835008897 ABC-ATPase subunit interface; other site 266835008898 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 266835008899 thiamine transporter substrate binding subunit; Provisional; Region: tbpA; PRK11205 266835008900 Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564 266835008901 Thiamine pyrophosphokinase; Region: TPK; cd07995 266835008902 active site 266835008903 dimerization interface [polypeptide binding]; other site 266835008904 thiamine binding site [chemical binding]; other site 266835008905 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 266835008906 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 266835008907 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 266835008908 Post-segregation antitoxin (ccd killing mechanism protein) encoded by the F plasmid [General function prediction only]; Region: COG5302 266835008909 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 266835008910 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 266835008911 GDP-binding site [chemical binding]; other site 266835008912 ACT binding site; other site 266835008913 IMP binding site; other site 266835008914 EamA-like transporter family; Region: EamA; pfam00892 266835008915 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 266835008916 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 266835008917 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 266835008918 ligand binding site [chemical binding]; other site 266835008919 NAD binding site [chemical binding]; other site 266835008920 dimerization interface [polypeptide binding]; other site 266835008921 catalytic site [active] 266835008922 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 266835008923 putative L-serine binding site [chemical binding]; other site 266835008924 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cd01494 266835008925 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 266835008926 catalytic residue [active] 266835008927 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 266835008928 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 266835008929 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14315 266835008930 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 266835008931 active site 266835008932 substrate binding site [chemical binding]; other site 266835008933 metal binding site [ion binding]; metal-binding site 266835008934 ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465 266835008935 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266835008936 Walker A motif; other site 266835008937 ATP binding site [chemical binding]; other site 266835008938 Walker B motif; other site 266835008939 arginine finger; other site 266835008940 Peptidase family M41; Region: Peptidase_M41; pfam01434 266835008941 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 266835008942 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 266835008943 Ligand Binding Site [chemical binding]; other site 266835008944 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 266835008945 putative outer membrane lipoprotein; Provisional; Region: PRK09967 266835008946 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 266835008947 ligand binding site [chemical binding]; other site 266835008948 translocation protein TolB; Provisional; Region: tolB; PRK05137 266835008949 TolB amino-terminal domain; Region: TolB_N; pfam04052 266835008950 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 266835008951 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 266835008952 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 266835008953 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 266835008954 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 266835008955 TonB family C-terminal domain; Region: tonB_Cterm; TIGR01352 266835008956 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 266835008957 TolR protein; Region: tolR; TIGR02801 266835008958 TolQ protein; Region: tolQ; TIGR02796 266835008959 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 266835008960 active site 266835008961 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 266835008962 phosphodiesterase YaeI; Provisional; Region: PRK11340 266835008963 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 266835008964 putative active site [active] 266835008965 putative metal binding site [ion binding]; other site 266835008966 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 266835008967 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266835008968 Walker A motif; other site 266835008969 ATP binding site [chemical binding]; other site 266835008970 Walker B motif; other site 266835008971 arginine finger; other site 266835008972 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 266835008973 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 266835008974 RuvA N terminal domain; Region: RuvA_N; pfam01330 266835008975 Hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase; cl00205 266835008976 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB-like; cd09875 266835008977 putative active site [active] 266835008978 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 266835008979 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 266835008980 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 266835008981 active site 266835008982 putative DNA-binding cleft [nucleotide binding]; other site 266835008983 dimer interface [polypeptide binding]; other site 266835008984 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5317 266835008985 Predicted permeases [General function prediction only]; Region: COG0730 266835008986 Methyltransferase domain; Region: Methyltransf_31; pfam13847 266835008987 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266835008988 S-adenosylmethionine binding site [chemical binding]; other site 266835008989 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 266835008990 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 266835008991 AsnC family; Region: AsnC_trans_reg; pfam01037 266835008992 EamA-like transporter family; Region: EamA; pfam00892 266835008993 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 266835008994 thiamine phosphate binding site [chemical binding]; other site 266835008995 active site 266835008996 pyrophosphate binding site [ion binding]; other site 266835008997 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 266835008998 Sel1-like repeats; Region: SEL1; smart00671 266835008999 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276 266835009000 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 266835009001 putative NAD(P) binding site [chemical binding]; other site 266835009002 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266835009003 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266835009004 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 266835009005 dimerization interface [polypeptide binding]; other site 266835009006 elongation factor P; Validated; Region: PRK00529 266835009007 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 266835009008 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 266835009009 RNA binding site [nucleotide binding]; other site 266835009010 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 266835009011 RNA binding site [nucleotide binding]; other site 266835009012 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 266835009013 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 266835009014 active site 266835009015 dimerization interface [polypeptide binding]; other site 266835009016 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 266835009017 hypothetical protein; Validated; Region: PRK09039 266835009018 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 266835009019 ligand binding site [chemical binding]; other site 266835009020 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 266835009021 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 266835009022 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 266835009023 active site 266835009024 Zn binding site [ion binding]; other site 266835009025 Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969 266835009026 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 266835009027 ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204 266835009028 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 266835009029 ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins; Region: ABC_MTABC3_MDL1_MDL2; cd03249 266835009030 Walker A/P-loop; other site 266835009031 ATP binding site [chemical binding]; other site 266835009032 Q-loop/lid; other site 266835009033 ABC transporter signature motif; other site 266835009034 Walker B; other site 266835009035 D-loop; other site 266835009036 H-loop/switch region; other site 266835009037 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00528 266835009038 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266835009039 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266835009040 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835009041 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 266835009042 NAD(P) binding site [chemical binding]; other site 266835009043 active site 266835009044 Predicted integral membrane protein [Function unknown]; Region: COG5500 266835009045 Uncharacterized protein conserved in bacteria [Posttranslational modification, protein turnover, chaperones]; Region: COG3526 266835009046 hypothetical protein; Validated; Region: PRK00110 266835009047 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266835009048 dimerization interface [polypeptide binding]; other site 266835009049 putative DNA binding site [nucleotide binding]; other site 266835009050 putative Zn2+ binding site [ion binding]; other site 266835009051 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 266835009052 hydrophobic ligand binding site; other site 266835009053 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_8; cd08901 266835009054 putative hydrophobic ligand binding site [chemical binding]; other site 266835009055 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 266835009056 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 266835009057 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 266835009058 putative active site [active] 266835009059 metal binding site [ion binding]; metal-binding site 266835009060 homodimer binding site [polypeptide binding]; other site 266835009061 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212 266835009062 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 266835009063 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 266835009064 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266835009065 Walker A motif; other site 266835009066 ATP binding site [chemical binding]; other site 266835009067 Walker B motif; other site 266835009068 arginine finger; other site 266835009069 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 266835009070 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 266835009071 Coenzyme A binding pocket [chemical binding]; other site 266835009072 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3825 266835009073 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 266835009074 methionine sulfoxide reductase B; Provisional; Region: PRK00222 266835009075 SelR domain; Region: SelR; pfam01641 266835009076 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 266835009077 Low molecular weight phosphatase family; Region: LMWPc; cd00115 266835009078 active site 266835009079 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3750 266835009080 pyruvate carboxylase; Reviewed; Region: PRK12999 266835009081 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 266835009082 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 266835009083 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 266835009084 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 266835009085 active site 266835009086 catalytic residues [active] 266835009087 metal binding site [ion binding]; metal-binding site 266835009088 homodimer binding site [polypeptide binding]; other site 266835009089 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 266835009090 carboxyltransferase (CT) interaction site; other site 266835009091 biotinylation site [posttranslational modification]; other site 266835009092 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 266835009093 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 266835009094 dimerization interface [polypeptide binding]; other site 266835009095 ligand binding site [chemical binding]; other site 266835009096 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 266835009097 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 266835009098 Walker A/P-loop; other site 266835009099 ATP binding site [chemical binding]; other site 266835009100 Q-loop/lid; other site 266835009101 ABC transporter signature motif; other site 266835009102 Walker B; other site 266835009103 D-loop; other site 266835009104 H-loop/switch region; other site 266835009105 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 266835009106 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 266835009107 Walker A/P-loop; other site 266835009108 ATP binding site [chemical binding]; other site 266835009109 Q-loop/lid; other site 266835009110 ABC transporter signature motif; other site 266835009111 Walker B; other site 266835009112 D-loop; other site 266835009113 H-loop/switch region; other site 266835009114 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 266835009115 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 266835009116 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 266835009117 TM-ABC transporter signature motif; other site 266835009118 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 266835009119 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 266835009120 TM-ABC transporter signature motif; other site 266835009121 Proline racemase [Amino acid transport and metabolism]; Region: COG3938 266835009122 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 266835009123 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 266835009124 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 266835009125 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 266835009126 inhibitor site; inhibition site 266835009127 active site 266835009128 dimer interface [polypeptide binding]; other site 266835009129 catalytic residue [active] 266835009130 Transcriptional regulators [Transcription]; Region: GntR; COG1802 266835009131 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266835009132 DNA-binding site [nucleotide binding]; DNA binding site 266835009133 FCD domain; Region: FCD; cl11656 266835009134 Predicted transcriptional regulators [Transcription]; Region: COG1733 266835009135 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 266835009136 SnoaL-like domain; Region: SnoaL_2; pfam12680 266835009137 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 266835009138 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 266835009139 tetrameric interface [polypeptide binding]; other site 266835009140 NAD binding site [chemical binding]; other site 266835009141 catalytic residues [active] 266835009142 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266835009143 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266835009144 LysR substrate binding domain; Region: LysR_substrate; pfam03466 266835009145 dimerization interface [polypeptide binding]; other site 266835009146 PLA2_plant: Plant-specific sub-family of Phospholipase A2, a super-family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. Enzymatically active PLA2 cleaves the sn-2 position of the glycerol backbone of...; Region: PLA2_plant; cd04706 266835009147 putative metal binding site; other site 266835009148 putative catalytic residues; other site 266835009149 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 266835009150 putative active site [active] 266835009151 catalytic site [active] 266835009152 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 266835009153 PLD-like domain; Region: PLDc_2; pfam13091 266835009154 putative active site [active] 266835009155 catalytic site [active] 266835009156 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 266835009157 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 266835009158 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 266835009159 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 266835009160 YcjX-like family, DUF463; Region: DUF463; cl01193 266835009161 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 266835009162 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 266835009163 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 266835009164 active site 266835009165 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 266835009166 dimer interface [polypeptide binding]; other site 266835009167 substrate binding site [chemical binding]; other site 266835009168 catalytic residues [active] 266835009169 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 266835009170 putative active site [active] 266835009171 Ap4A binding site [chemical binding]; other site 266835009172 nudix motif; other site 266835009173 putative metal binding site [ion binding]; other site 266835009174 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 266835009175 NodB motif; other site 266835009176 putative active site [active] 266835009177 putative catalytic site [active] 266835009178 Zn binding site [ion binding]; other site 266835009179 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 266835009180 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 266835009181 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 266835009182 protein binding site [polypeptide binding]; other site 266835009183 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 266835009184 Catalytic dyad [active] 266835009185 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 266835009186 Peptidase family M23; Region: Peptidase_M23; pfam01551 266835009187 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 266835009188 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 266835009189 Mechanosensitive ion channel; Region: MS_channel; pfam00924 266835009190 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266835009191 Major Facilitator Superfamily; Region: MFS_1; pfam07690 266835009192 putative substrate translocation pore; other site 266835009193 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 266835009194 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 266835009195 active site 266835009196 (T/H)XGH motif; other site 266835009197 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 266835009198 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 266835009199 putative catalytic cysteine [active] 266835009200 gamma-glutamyl kinase; Provisional; Region: PRK05429 266835009201 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 266835009202 nucleotide binding site [chemical binding]; other site 266835009203 homotetrameric interface [polypeptide binding]; other site 266835009204 putative phosphate binding site [ion binding]; other site 266835009205 putative allosteric binding site; other site 266835009206 PUA domain; Region: PUA; pfam01472 266835009207 GTPase CgtA; Reviewed; Region: obgE; PRK12299 266835009208 GTP1/OBG; Region: GTP1_OBG; pfam01018 266835009209 Obg GTPase; Region: Obg; cd01898 266835009210 G1 box; other site 266835009211 GTP/Mg2+ binding site [chemical binding]; other site 266835009212 Switch I region; other site 266835009213 G2 box; other site 266835009214 G3 box; other site 266835009215 Switch II region; other site 266835009216 G4 box; other site 266835009217 G5 box; other site 266835009218 Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568 266835009219 putative catalytic site [active] 266835009220 putative metal binding site [ion binding]; other site 266835009221 putative phosphate binding site [ion binding]; other site 266835009222 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 266835009223 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 266835009224 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 266835009225 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 266835009226 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 266835009227 Uncharacterized conserved protein [Function unknown]; Region: COG3743 266835009228 Transposase; Region: HTH_Tnp_1; pfam01527 266835009229 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 266835009230 Transposase; Region: DEDD_Tnp_IS110; pfam01548 266835009231 Integrase core domain; Region: rve_3; pfam13683 266835009232 TPR repeat; Region: TPR_11; pfam13414 266835009233 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266835009234 TPR motif; other site 266835009235 TPR repeat; Region: TPR_11; pfam13414 266835009236 binding surface 266835009237 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266835009238 binding surface 266835009239 TPR motif; other site 266835009240 Sulfotransferase family; Region: Sulfotransfer_3; pfam13469 266835009241 Porin subfamily; Region: Porin_2; pfam02530 266835009242 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 266835009243 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266835009244 DNA binding residues [nucleotide binding] 266835009245 dimerization interface [polypeptide binding]; other site 266835009246 multiple promoter invertase; Provisional; Region: mpi; PRK13413 266835009247 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 266835009248 catalytic residues [active] 266835009249 catalytic nucleophile [active] 266835009250 Presynaptic Site I dimer interface [polypeptide binding]; other site 266835009251 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 266835009252 Synaptic Flat tetramer interface [polypeptide binding]; other site 266835009253 Synaptic Site I dimer interface [polypeptide binding]; other site 266835009254 DNA binding site [nucleotide binding] 266835009255 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 266835009256 DNA-binding interface [nucleotide binding]; DNA binding site 266835009257 integrase; Provisional; Region: PRK09692 266835009258 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 266835009259 active site 266835009260 Int/Topo IB signature motif; other site 266835009261 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 266835009262 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 266835009263 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 266835009264 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 266835009265 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 266835009266 cyclase homology domain; Region: CHD; cd07302 266835009267 nucleotidyl binding site; other site 266835009268 metal binding site [ion binding]; metal-binding site 266835009269 dimer interface [polypeptide binding]; other site 266835009270 Predicted integral membrane protein [Function unknown]; Region: COG5616 266835009271 TPR repeat; Region: TPR_11; pfam13414 266835009272 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266835009273 binding surface 266835009274 TPR motif; other site 266835009275 Tetratricopeptide repeat; Region: TPR_12; pfam13424 266835009276 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266835009277 binding surface 266835009278 TPR motif; other site 266835009279 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 266835009280 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 266835009281 ATP binding site [chemical binding]; other site 266835009282 putative Mg++ binding site [ion binding]; other site 266835009283 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 266835009284 nucleotide binding region [chemical binding]; other site 266835009285 ATP-binding site [chemical binding]; other site 266835009286 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 266835009287 HRDC domain; Region: HRDC; pfam00570 266835009288 Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133 266835009289 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 266835009290 NAD(P) binding site [chemical binding]; other site 266835009291 catalytic residues [active] 266835009292 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 266835009293 2-deoxy-D-gluconate 3-dehydrogenase; Region: kduD; TIGR01832 266835009294 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835009295 NAD(P) binding site [chemical binding]; other site 266835009296 active site 266835009297 glucuronate isomerase; Reviewed; Region: PRK02925 266835009298 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 266835009299 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 266835009300 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 266835009301 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 266835009302 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 266835009303 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 266835009304 gamma subunit interface [polypeptide binding]; other site 266835009305 epsilon subunit interface [polypeptide binding]; other site 266835009306 LBP interface [polypeptide binding]; other site 266835009307 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 266835009308 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 266835009309 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 266835009310 alpha subunit interaction interface [polypeptide binding]; other site 266835009311 Walker A motif; other site 266835009312 ATP binding site [chemical binding]; other site 266835009313 Walker B motif; other site 266835009314 inhibitor binding site; inhibition site 266835009315 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 266835009316 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 266835009317 core domain interface [polypeptide binding]; other site 266835009318 delta subunit interface [polypeptide binding]; other site 266835009319 epsilon subunit interface [polypeptide binding]; other site 266835009320 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 266835009321 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 266835009322 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 266835009323 beta subunit interaction interface [polypeptide binding]; other site 266835009324 Walker A motif; other site 266835009325 ATP binding site [chemical binding]; other site 266835009326 Walker B motif; other site 266835009327 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 266835009328 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 266835009329 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 266835009330 Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794 266835009331 aspartate racemase; Region: asp_race; TIGR00035 266835009332 primosome assembly protein PriA; Validated; Region: PRK05580 266835009333 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 266835009334 ATP binding site [chemical binding]; other site 266835009335 putative Mg++ binding site [ion binding]; other site 266835009336 helicase superfamily c-terminal domain; Region: HELICc; smart00490 266835009337 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 266835009338 active site 266835009339 intersubunit interactions; other site 266835009340 catalytic residue [active] 266835009341 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 266835009342 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 266835009343 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 266835009344 Predicted secreted (periplasmic) protein [Function unknown]; Region: COG5468 266835009345 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 266835009346 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 266835009347 HIGH motif; other site 266835009348 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 266835009349 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 266835009350 active site 266835009351 KMSKS motif; other site 266835009352 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 266835009353 tRNA binding surface [nucleotide binding]; other site 266835009354 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 266835009355 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 266835009356 catalytic residue [active] 266835009357 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 266835009358 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 266835009359 active site 266835009360 catalytic tetrad [active] 266835009361 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 266835009362 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266835009363 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266835009364 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_10; cd08480 266835009365 putative effector binding pocket; other site 266835009366 putative dimerization interface [polypeptide binding]; other site 266835009367 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 266835009368 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266835009369 putative substrate translocation pore; other site 266835009370 SGNH_hydrolase subfamily, similar to the putative arylesterase/acylhydrolase from the rumen anaerobe Prevotella bryantii XynE. The P. bryantii XynE gene is located in a xylanase gene cluster. SGNH hydrolases are a diverse family of lipases and esterases; Region: XynE_like; cd01830 266835009371 active site 266835009372 catalytic triad [active] 266835009373 oxyanion hole [active] 266835009374 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 266835009375 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 266835009376 active site 266835009377 catalytic tetrad [active] 266835009378 Usg protein, probable subunit of phosphoribosylanthranilate isomerase [Amino acid transport and metabolism]; Region: COG5425 266835009379 acetyl-CoA synthetase; Provisional; Region: PRK00174 266835009380 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 266835009381 active site 266835009382 CoA binding site [chemical binding]; other site 266835009383 acyl-activating enzyme (AAE) consensus motif; other site 266835009384 AMP binding site [chemical binding]; other site 266835009385 acetate binding site [chemical binding]; other site 266835009386 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 266835009387 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 266835009388 MOSC domain; Region: MOSC; pfam03473 266835009389 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 266835009390 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266835009391 S-adenosylmethionine binding site [chemical binding]; other site 266835009392 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 266835009393 Putative Flp pilus-assembly TadE/G-like; Region: Tad; pfam13400 266835009394 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 266835009395 metal ion-dependent adhesion site (MIDAS); other site 266835009396 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 266835009397 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 266835009398 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 266835009399 heat shock protein HtpX; Provisional; Region: PRK01345 266835009400 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 266835009401 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 266835009402 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266835009403 S-adenosylmethionine binding site [chemical binding]; other site 266835009404 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5360 266835009405 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 266835009406 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 266835009407 purine monophosphate binding site [chemical binding]; other site 266835009408 dimer interface [polypeptide binding]; other site 266835009409 putative catalytic residues [active] 266835009410 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 266835009411 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 266835009412 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 266835009413 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 266835009414 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 266835009415 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 266835009416 YCII-related domain; Region: YCII; cl00999 266835009417 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 266835009418 Phosphoesterase family; Region: Phosphoesterase; pfam04185 266835009419 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4332 266835009420 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 266835009421 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 266835009422 G1 box; other site 266835009423 putative GEF interaction site [polypeptide binding]; other site 266835009424 GTP/Mg2+ binding site [chemical binding]; other site 266835009425 Switch I region; other site 266835009426 G2 box; other site 266835009427 G3 box; other site 266835009428 Switch II region; other site 266835009429 G4 box; other site 266835009430 G5 box; other site 266835009431 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 266835009432 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 266835009433 Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism]; Region: PhoD; COG3540 266835009434 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 266835009435 putative active site [active] 266835009436 putative metal binding site [ion binding]; other site 266835009437 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 266835009438 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 266835009439 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266835009440 Major Facilitator Superfamily; Region: MFS_1; pfam07690 266835009441 putative substrate translocation pore; other site 266835009442 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266835009443 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266835009444 Domain of unknown function, E. rectale Gene description (DUF3879); Region: DUF3879; pfam12995 266835009445 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 266835009446 dimer interface [polypeptide binding]; other site 266835009447 substrate binding site [chemical binding]; other site 266835009448 metal binding sites [ion binding]; metal-binding site 266835009449 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 266835009450 Predicted membrane protein [Function unknown]; Region: COG3762 266835009451 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 266835009452 Repair protein; Region: Repair_PSII; pfam04536 266835009453 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 266835009454 Repair protein; Region: Repair_PSII; pfam04536 266835009455 LemA family; Region: LemA; pfam04011 266835009456 pyridoxamine kinase; Validated; Region: PRK05756 266835009457 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 266835009458 pyridoxal binding site [chemical binding]; other site 266835009459 dimer interface [polypeptide binding]; other site 266835009460 ATP binding site [chemical binding]; other site 266835009461 Predicted nuclease (RNAse H fold) [General function prediction only]; Region: COG4923 266835009462 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 266835009463 active site clefts [active] 266835009464 zinc binding site [ion binding]; other site 266835009465 dimer interface [polypeptide binding]; other site 266835009466 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 266835009467 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 266835009468 active site 266835009469 Zn binding site [ion binding]; other site 266835009470 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 266835009471 Transposase; Region: DEDD_Tnp_IS110; pfam01548 266835009472 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 266835009473 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 266835009474 Transposase; Region: DEDD_Tnp_IS110; pfam01548 266835009475 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 266835009476 Uncharacterized conserved protein [Function unknown]; Region: COG5476 266835009477 Protein of unknown function (DUF1485); Region: DUF1485; pfam07364 266835009478 MlrC C-terminus; Region: MlrC_C; pfam07171 266835009479 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 266835009480 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835009481 dimer interface [polypeptide binding]; other site 266835009482 conserved gate region; other site 266835009483 ABC-ATPase subunit interface; other site 266835009484 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 266835009485 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835009486 conserved gate region; other site 266835009487 dimer interface [polypeptide binding]; other site 266835009488 putative PBP binding loops; other site 266835009489 ABC-ATPase subunit interface; other site 266835009490 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 266835009491 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 266835009492 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835009493 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 266835009494 NAD(P) binding site [chemical binding]; other site 266835009495 active site 266835009496 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 266835009497 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 266835009498 Walker A/P-loop; other site 266835009499 ATP binding site [chemical binding]; other site 266835009500 Q-loop/lid; other site 266835009501 ABC transporter signature motif; other site 266835009502 Walker B; other site 266835009503 D-loop; other site 266835009504 H-loop/switch region; other site 266835009505 TOBE domain; Region: TOBE; pfam03459 266835009506 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 266835009507 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 266835009508 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 266835009509 putative active site [active] 266835009510 hypothetical protein; Validated; Region: PRK01310 266835009511 Predicted integral membrane protein [Function unknown]; Region: COG0762 266835009512 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266835009513 non-specific DNA binding site [nucleotide binding]; other site 266835009514 salt bridge; other site 266835009515 sequence-specific DNA binding site [nucleotide binding]; other site 266835009516 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 266835009517 NADPH bind site [chemical binding]; other site 266835009518 putative FMN binding site [chemical binding]; other site 266835009519 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 266835009520 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 266835009521 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 266835009522 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 266835009523 tonB-system energizer ExbB; Region: exbB; TIGR02797 266835009524 Isochorismatase family; Region: Isochorismatase; pfam00857 266835009525 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 266835009526 catalytic triad [active] 266835009527 conserved cis-peptide bond; other site 266835009528 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 266835009529 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 266835009530 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 266835009531 classical (c) SDRs; Region: SDR_c; cd05233 266835009532 NAD(P) binding site [chemical binding]; other site 266835009533 active site 266835009534 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 266835009535 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 266835009536 TM-ABC transporter signature motif; other site 266835009537 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 266835009538 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 266835009539 TM-ABC transporter signature motif; other site 266835009540 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 266835009541 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 266835009542 Walker A/P-loop; other site 266835009543 ATP binding site [chemical binding]; other site 266835009544 Q-loop/lid; other site 266835009545 ABC transporter signature motif; other site 266835009546 Walker B; other site 266835009547 D-loop; other site 266835009548 H-loop/switch region; other site 266835009549 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 266835009550 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 266835009551 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 266835009552 putative ligand binding site [chemical binding]; other site 266835009553 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 266835009554 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 266835009555 dimer interface [polypeptide binding]; other site 266835009556 active site 266835009557 Acyl CoA:acetate/3-ketoacid CoA transferase, beta subunit [Lipid metabolism]; Region: AtoA; COG2057 266835009558 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 266835009559 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 266835009560 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 266835009561 Bacterial transcriptional regulator; Region: IclR; pfam01614 266835009562 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 266835009563 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 266835009564 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 266835009565 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 266835009566 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 266835009567 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 266835009568 homodimer interface [polypeptide binding]; other site 266835009569 active site 266835009570 TDP-binding site; other site 266835009571 acceptor substrate-binding pocket; other site 266835009572 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266835009573 DNA-binding site [nucleotide binding]; DNA binding site 266835009574 Transcriptional regulators [Transcription]; Region: GntR; COG1802 266835009575 FCD domain; Region: FCD; pfam07729 266835009576 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 266835009577 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 266835009578 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 266835009579 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835009580 putative PBP binding loops; other site 266835009581 ABC-ATPase subunit interface; other site 266835009582 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 266835009583 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835009584 dimer interface [polypeptide binding]; other site 266835009585 conserved gate region; other site 266835009586 putative PBP binding loops; other site 266835009587 ABC-ATPase subunit interface; other site 266835009588 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 266835009589 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266835009590 Walker A/P-loop; other site 266835009591 ATP binding site [chemical binding]; other site 266835009592 Q-loop/lid; other site 266835009593 ABC transporter signature motif; other site 266835009594 Walker B; other site 266835009595 D-loop; other site 266835009596 H-loop/switch region; other site 266835009597 TOBE domain; Region: TOBE_2; pfam08402 266835009598 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 266835009599 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 266835009600 active site 266835009601 TDP-binding site; other site 266835009602 acceptor substrate-binding pocket; other site 266835009603 homodimer interface [polypeptide binding]; other site 266835009604 Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450 266835009605 Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450 266835009606 Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450 266835009607 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 266835009608 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 266835009609 NAD(P) binding site [chemical binding]; other site 266835009610 catalytic residues [active] 266835009611 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 266835009612 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266835009613 substrate binding site [chemical binding]; other site 266835009614 oxyanion hole (OAH) forming residues; other site 266835009615 trimer interface [polypeptide binding]; other site 266835009616 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 266835009617 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 266835009618 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 266835009619 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 266835009620 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 266835009621 TM-ABC transporter signature motif; other site 266835009622 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 266835009623 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 266835009624 TM-ABC transporter signature motif; other site 266835009625 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 266835009626 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 266835009627 Walker A/P-loop; other site 266835009628 ATP binding site [chemical binding]; other site 266835009629 Q-loop/lid; other site 266835009630 ABC transporter signature motif; other site 266835009631 Walker B; other site 266835009632 D-loop; other site 266835009633 H-loop/switch region; other site 266835009634 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 266835009635 Periplasmic sugar-binding component of uncharacterized ABC-type transport systems that are members of the pentose/hexose sugar-binding protein family of the type I periplasmic binding protein superfamily; Region: PBP1_ABC_sugar_binding_like_1; cd06300 266835009636 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 266835009637 putative ligand binding site [chemical binding]; other site 266835009638 Glycoside hydrolase family 15, N-terminal domain; Region: GH15_N; cd07430 266835009639 Domain interface; other site 266835009640 glucan 1,4-alpha-glucosidase; Region: glucan_glucosid; TIGR01535 266835009641 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 266835009642 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 266835009643 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 266835009644 glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12853 266835009645 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 266835009646 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 266835009647 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 266835009648 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 266835009649 nucleotide binding site [chemical binding]; other site 266835009650 Predicted transcriptional regulator [Transcription]; Region: COG4957 266835009651 transaminase; Validated; Region: PRK07324 266835009652 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 266835009653 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266835009654 homodimer interface [polypeptide binding]; other site 266835009655 catalytic residue [active] 266835009656 enterobactin exporter EntS; Provisional; Region: PRK10489 266835009657 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266835009658 putative substrate translocation pore; other site 266835009659 NIPSNAP; Region: NIPSNAP; pfam07978 266835009660 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 266835009661 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 266835009662 catalytic triad [active] 266835009663 tellurium resistance terB-like protein, subgroup 2; Region: terB_like_2; cd07313 266835009664 putative metal binding site [ion binding]; other site 266835009665 Uncharacterized membrane-bound protein [Function unknown]; Region: COG3898 266835009666 HemY protein N-terminus; Region: HemY_N; pfam07219 266835009667 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4223 266835009668 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 266835009669 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 266835009670 active site 266835009671 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 266835009672 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 266835009673 domain interfaces; other site 266835009674 active site 266835009675 UGMP family protein; Validated; Region: PRK09604 266835009676 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 266835009677 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 266835009678 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 266835009679 YCII-related domain; Region: YCII; cl00999 266835009680 Uncharacterized conserved protein [Function unknown]; Region: COG2947 266835009681 Predicted methyltransferase [General function prediction only]; Region: COG3897 266835009682 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 266835009683 Protein of unknown function (DUF1761); Region: DUF1761; pfam08570 266835009684 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 266835009685 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266835009686 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 266835009687 dimerization interface [polypeptide binding]; other site 266835009688 substrate binding pocket [chemical binding]; other site 266835009689 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 266835009690 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 266835009691 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266835009692 active site 266835009693 phosphorylation site [posttranslational modification] 266835009694 intermolecular recognition site; other site 266835009695 dimerization interface [polypeptide binding]; other site 266835009696 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266835009697 DNA binding site [nucleotide binding] 266835009698 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 266835009699 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 266835009700 ligand binding site [chemical binding]; other site 266835009701 flexible hinge region; other site 266835009702 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 266835009703 putative catalytic site [active] 266835009704 putative phosphate binding site [ion binding]; other site 266835009705 active site 266835009706 metal binding site A [ion binding]; metal-binding site 266835009707 DNA binding site [nucleotide binding] 266835009708 putative AP binding site [nucleotide binding]; other site 266835009709 putative metal binding site B [ion binding]; other site 266835009710 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 266835009711 Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548 266835009712 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 266835009713 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 266835009714 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 266835009715 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 266835009716 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 266835009717 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 266835009718 Nitrogen regulatory protein P-II; Region: P-II; smart00938 266835009719 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 266835009720 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 266835009721 active site 266835009722 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 266835009723 catalytic triad [active] 266835009724 dimer interface [polypeptide binding]; other site 266835009725 2-octaprenyl-6-methoxyphenyl hydroxylase; Provisional; Region: PRK07333 266835009726 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 266835009727 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 266835009728 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 266835009729 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3132 266835009730 hypothetical protein; Provisional; Region: PRK11239 266835009731 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 266835009732 Sulfatase; Region: Sulfatase; cl17466 266835009733 Predicted nucleotidyltransferase [General function prediction only]; Region: COG3541 266835009734 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 266835009735 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 266835009736 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK09078 266835009737 L-aspartate oxidase; Provisional; Region: PRK06175 266835009738 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 266835009739 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit-like; composed of predominantly uncharacterized bacterial proteins with similarity to the E. coli SdhD subunit. One characterized protein is the respiratory...; Region: SQR_TypeC_SdhD_like; cd03495 266835009740 putative SdhC subunit interface [polypeptide binding]; other site 266835009741 putative proximal heme binding site [chemical binding]; other site 266835009742 putative Iron-sulfur protein interface [polypeptide binding]; other site 266835009743 putative proximal quinone binding site; other site 266835009744 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 266835009745 Iron-sulfur protein interface; other site 266835009746 proximal quinone binding site [chemical binding]; other site 266835009747 SdhD (CybS) interface [polypeptide binding]; other site 266835009748 proximal heme binding site [chemical binding]; other site 266835009749 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 266835009750 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266835009751 metal binding site [ion binding]; metal-binding site 266835009752 active site 266835009753 I-site; other site 266835009754 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 266835009755 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266835009756 metal binding site [ion binding]; metal-binding site 266835009757 active site 266835009758 I-site; other site 266835009759 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 266835009760 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 266835009761 substrate binding site [chemical binding]; other site 266835009762 ligand binding site [chemical binding]; other site 266835009763 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 266835009764 Transposase; Region: DEDD_Tnp_IS110; pfam01548 266835009765 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 266835009766 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266835009767 S-adenosylmethionine binding site [chemical binding]; other site 266835009768 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835009769 dimer interface [polypeptide binding]; other site 266835009770 conserved gate region; other site 266835009771 putative PBP binding loops; other site 266835009772 ABC-ATPase subunit interface; other site 266835009773 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 266835009774 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 266835009775 substrate binding pocket [chemical binding]; other site 266835009776 membrane-bound complex binding site; other site 266835009777 hinge residues; other site 266835009778 Transcriptional regulators [Transcription]; Region: MarR; COG1846 266835009779 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266835009780 putative Zn2+ binding site [ion binding]; other site 266835009781 putative DNA binding site [nucleotide binding]; other site 266835009782 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 266835009783 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 266835009784 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 266835009785 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 266835009786 RimM protein, required for 16S rRNA processing [Translation, ribosomal structure and biogenesis]; Region: RimM; COG0806 266835009787 RimM N-terminal domain; Region: RimM; pfam01782 266835009788 PRC-barrel domain; Region: PRC; pfam05239 266835009789 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 266835009790 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 266835009791 active site 266835009792 DNA binding site [nucleotide binding] 266835009793 Int/Topo IB signature motif; other site 266835009794 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3735 266835009795 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 266835009796 dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350 266835009797 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 266835009798 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 266835009799 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 266835009800 short chain dehydrogenase; Provisional; Region: PRK06123 266835009801 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835009802 NAD(P) binding site [chemical binding]; other site 266835009803 active site 266835009804 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 266835009805 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 266835009806 E3 interaction surface; other site 266835009807 lipoyl attachment site [posttranslational modification]; other site 266835009808 e3 binding domain; Region: E3_binding; pfam02817 266835009809 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 266835009810 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 266835009811 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 266835009812 TPP-binding site [chemical binding]; other site 266835009813 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 266835009814 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 266835009815 CoA binding domain; Region: CoA_binding; smart00881 266835009816 CoA-ligase; Region: Ligase_CoA; pfam00549 266835009817 Protein of unknown function (DUF1579); Region: DUF1579; pfam07617 266835009818 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 266835009819 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 266835009820 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 266835009821 CoA-ligase; Region: Ligase_CoA; pfam00549 266835009822 malate dehydrogenase; Reviewed; Region: PRK06223 266835009823 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 266835009824 NAD(P) binding site [chemical binding]; other site 266835009825 dimer interface [polypeptide binding]; other site 266835009826 tetramer (dimer of dimers) interface [polypeptide binding]; other site 266835009827 substrate binding site [chemical binding]; other site 266835009828 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 266835009829 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 266835009830 Coenzyme A binding pocket [chemical binding]; other site 266835009831 Predicted ATPase [General function prediction only]; Region: COG1485 266835009832 Protease inhibitor Inh; Region: Inh; pfam02974 266835009833 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 266835009834 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 266835009835 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 266835009836 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 266835009837 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 266835009838 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 266835009839 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 266835009840 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 266835009841 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 266835009842 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 266835009843 intracellular septation protein A; Reviewed; Region: PRK00259 266835009844 PPOX class probable FMN-dependent enzyme, DR_2398 family; Region: PPOX_FMN_DR2398; TIGR04025 266835009845 Predicted flavoprotein [General function prediction only]; Region: COG0431 266835009846 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 266835009847 Uncharacterized protein, 4-oxalocrotonate tautomerase homolog [General function prediction only]; Region: COG1942 266835009848 active site 1 [active] 266835009849 dimer interface [polypeptide binding]; other site 266835009850 hexamer interface [polypeptide binding]; other site 266835009851 active site 2 [active] 266835009852 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 266835009853 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 266835009854 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 266835009855 catalytic residues [active] 266835009856 central insert; other site 266835009857 heme exporter protein CcmD; Region: cytochro_ccmD; TIGR03141 266835009858 ABC-type transport system involved in cytochrome c biogenesis, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CcmB; COG2386 266835009859 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13539 266835009860 Cytochrome c biogenesis ATP-binding export protein; Region: ABC_CcmA_heme_exporter; cd03231 266835009861 Walker A/P-loop; other site 266835009862 ATP binding site [chemical binding]; other site 266835009863 Q-loop/lid; other site 266835009864 ABC transporter signature motif; other site 266835009865 Walker B; other site 266835009866 D-loop; other site 266835009867 H-loop/switch region; other site 266835009868 aconitate hydratase; Validated; Region: PRK09277 266835009869 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 266835009870 substrate binding site [chemical binding]; other site 266835009871 ligand binding site [chemical binding]; other site 266835009872 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 266835009873 substrate binding site [chemical binding]; other site 266835009874 Uncharacterized secreted protein [Function unknown]; Region: COG5429 266835009875 Protein of unknown function (DUF2794); Region: DUF2794; pfam10984 266835009876 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 266835009877 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 266835009878 Coenzyme A binding pocket [chemical binding]; other site 266835009879 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 266835009880 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 266835009881 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 266835009882 FtsX-like permease family; Region: FtsX; pfam02687 266835009883 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181 266835009884 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 266835009885 Walker A/P-loop; other site 266835009886 ATP binding site [chemical binding]; other site 266835009887 Q-loop/lid; other site 266835009888 ABC transporter signature motif; other site 266835009889 Walker B; other site 266835009890 D-loop; other site 266835009891 H-loop/switch region; other site 266835009892 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 266835009893 active site 266835009894 catalytic triad [active] 266835009895 oxyanion hole [active] 266835009896 switch loop; other site 266835009897 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 266835009898 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 266835009899 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 266835009900 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 266835009901 Low molecular weight phosphatase family; Region: LMWPc; cd00115 266835009902 active site 266835009903 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_b; cd00914 266835009904 aromatic arch; other site 266835009905 DCoH dimer interaction site [polypeptide binding]; other site 266835009906 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 266835009907 DCoH tetramer interaction site [polypeptide binding]; other site 266835009908 substrate binding site [chemical binding]; other site 266835009909 Uncharacterized conserved protein [Function unknown]; Region: COG3339 266835009910 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 266835009911 Invasion associated locus B (IalB) protein; Region: IalB; cl02207 266835009912 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 266835009913 ClC chloride channel family. These protein sequences, closely related to the ClC Eric family, are putative halogen ion (Cl-, Br- and I-) transport proteins found in eubacteria. They belong to the ClC superfamily of chloride ion channels, which share a...; Region: EriC_like; cd01034 266835009914 putative ion selectivity filter; other site 266835009915 putative pore gating glutamate residue; other site 266835009916 putative H+/Cl- coupling transport residue; other site 266835009917 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 266835009918 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 266835009919 FeS/SAM binding site; other site 266835009920 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 266835009921 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 266835009922 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 266835009923 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 266835009924 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 266835009925 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 266835009926 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266835009927 metal binding site [ion binding]; metal-binding site 266835009928 active site 266835009929 I-site; other site 266835009930 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 266835009931 argininosuccinate synthase; Provisional; Region: PRK13820 266835009932 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 266835009933 ANP binding site [chemical binding]; other site 266835009934 Substrate Binding Site II [chemical binding]; other site 266835009935 Substrate Binding Site I [chemical binding]; other site 266835009936 Transglycosylase SLT domain; Region: SLT_2; pfam13406 266835009937 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 266835009938 N-acetyl-D-glucosamine binding site [chemical binding]; other site 266835009939 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4307 266835009940 Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005 266835009941 Uncharacterized protein with a bacterial SH3 domain homologue [Function unknown]; Region: COG4991 266835009942 Bacterial SH3 domain; Region: SH3_3; pfam08239 266835009943 Protein of unknown function (DUF1236); Region: DUF1236; pfam06823 266835009944 CAAX protease self-immunity; Region: Abi; pfam02517 266835009945 signal recognition particle protein; Provisional; Region: PRK10867 266835009946 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 266835009947 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 266835009948 P loop; other site 266835009949 GTP binding site [chemical binding]; other site 266835009950 Signal peptide binding domain; Region: SRP_SPB; pfam02978 266835009951 chorismate mutase; Provisional; Region: PRK09239 266835009952 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 266835009953 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 266835009954 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 266835009955 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_1; cd07818 266835009956 putative hydrophobic ligand binding site [chemical binding]; other site 266835009957 DoxX-like family; Region: DoxX_2; pfam13564 266835009958 Predicted membrane protein [Function unknown]; Region: COG3781 266835009959 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3602 266835009960 ACT domain; Region: ACT_3; pfam10000 266835009961 Family description; Region: ACT_7; pfam13840 266835009962 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 266835009963 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 266835009964 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 266835009965 Coenzyme A binding pocket [chemical binding]; other site 266835009966 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 266835009967 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 266835009968 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 266835009969 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 266835009970 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 266835009971 ATP binding site [chemical binding]; other site 266835009972 putative Mg++ binding site [ion binding]; other site 266835009973 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 266835009974 nucleotide binding region [chemical binding]; other site 266835009975 ATP-binding site [chemical binding]; other site 266835009976 RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252 266835009977 RNA binding site [nucleotide binding]; other site 266835009978 Predicted membrane protein [Function unknown]; Region: COG3152 266835009979 Predicted membrane protein [Function unknown]; Region: COG3152 266835009980 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 266835009981 hydrophobic ligand binding site; other site 266835009982 MarR family; Region: MarR; pfam01047 266835009983 tartrate dehydrogenase; Region: TTC; TIGR02089 266835009984 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 266835009985 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_5; cd07238 266835009986 dimer interface [polypeptide binding]; other site 266835009987 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266835009988 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154 266835009989 homotrimer interaction site [polypeptide binding]; other site 266835009990 putative active site [active] 266835009991 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 266835009992 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 266835009993 substrate binding site [chemical binding]; other site 266835009994 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 266835009995 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 266835009996 Coenzyme A binding pocket [chemical binding]; other site 266835009997 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266835009998 dimerization interface [polypeptide binding]; other site 266835009999 putative DNA binding site [nucleotide binding]; other site 266835010000 putative Zn2+ binding site [ion binding]; other site 266835010001 Uncharacterized conserved protein [Function unknown]; Region: COG1801 266835010002 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 266835010003 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 266835010004 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 266835010005 dimerization interface [polypeptide binding]; other site 266835010006 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266835010007 dimer interface [polypeptide binding]; other site 266835010008 phosphorylation site [posttranslational modification] 266835010009 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266835010010 ATP binding site [chemical binding]; other site 266835010011 Mg2+ binding site [ion binding]; other site 266835010012 G-X-G motif; other site 266835010013 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 266835010014 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266835010015 active site 266835010016 phosphorylation site [posttranslational modification] 266835010017 intermolecular recognition site; other site 266835010018 dimerization interface [polypeptide binding]; other site 266835010019 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266835010020 DNA binding site [nucleotide binding] 266835010021 Domain of unknown function (DUF4173); Region: DUF4173; pfam13777 266835010022 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 266835010023 Uncharacterized conserved small protein [Function unknown]; Region: COG5515 266835010024 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448 266835010025 GIY-YIG motif/motif A; other site 266835010026 putative active site [active] 266835010027 putative metal binding site [ion binding]; other site 266835010028 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 266835010029 Uncharacterized conserved protein [Function unknown]; Region: COG4544 266835010030 DNA Polymerase Y-family; Region: PolY_like; cd03468 266835010031 active site 266835010032 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 266835010033 DNA binding site [nucleotide binding] 266835010034 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 266835010035 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434 266835010036 putative active site [active] 266835010037 putative PHP Thumb interface [polypeptide binding]; other site 266835010038 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 266835010039 generic binding surface I; other site 266835010040 generic binding surface II; other site 266835010041 Uncharacterized conserved protein [Function unknown]; Region: COG2835 266835010042 Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802 266835010043 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 266835010044 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 266835010045 catalytic residues [active] 266835010046 This CD includes bacterial (Agrobacterium tumefaciens and Caulobacter crescentus ProX, and Clostridium sticklandii PrdX) and eukaryotic (Plasmodium falciparum N-terminal ProRS editing domain) sequences. The C. sticklandii PrdX protein, a homolog of the...; Region: PrdX_deacylase; cd04335 266835010047 putative deacylase active site [active] 266835010048 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266835010049 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266835010050 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 266835010051 substrate binding pocket [chemical binding]; other site 266835010052 dimerization interface [polypeptide binding]; other site 266835010053 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 266835010054 Epoxide hydrolase N terminus; Region: EHN; pfam06441 266835010055 SapC; Region: SapC; pfam07277 266835010056 Uncharacterized iron-regulated protein [Function unknown]; Region: PiuC; COG3128 266835010057 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 266835010058 Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675 266835010059 Phage Tail Collar Domain; Region: Collar; pfam07484 266835010060 Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675 266835010061 Phage Tail Collar Domain; Region: Collar; pfam07484 266835010062 Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675 266835010063 Phage Tail Collar Domain; Region: Collar; pfam07484 266835010064 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 266835010065 Invasion protein B, involved in pathogenesis [General function prediction only]; Region: COG5342 266835010066 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 266835010067 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 266835010068 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 266835010069 active site 266835010070 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 266835010071 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 266835010072 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 266835010073 Predicted amidohydrolase [General function prediction only]; Region: COG3964 266835010074 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 266835010075 active site 266835010076 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 266835010077 homotrimer interaction site [polypeptide binding]; other site 266835010078 putative active site [active] 266835010079 Peptidase_C39 like family; Region: DUF3335; pfam11814 266835010080 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 266835010081 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4705 266835010082 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 266835010083 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 266835010084 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 266835010085 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 266835010086 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 266835010087 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266835010088 active site 266835010089 phosphorylation site [posttranslational modification] 266835010090 intermolecular recognition site; other site 266835010091 dimerization interface [polypeptide binding]; other site 266835010092 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266835010093 DNA binding site [nucleotide binding] 266835010094 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 266835010095 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266835010096 dimer interface [polypeptide binding]; other site 266835010097 phosphorylation site [posttranslational modification] 266835010098 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266835010099 ATP binding site [chemical binding]; other site 266835010100 Mg2+ binding site [ion binding]; other site 266835010101 G-X-G motif; other site 266835010102 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 266835010103 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 266835010104 Walker A/P-loop; other site 266835010105 ATP binding site [chemical binding]; other site 266835010106 Q-loop/lid; other site 266835010107 ABC transporter signature motif; other site 266835010108 Walker B; other site 266835010109 D-loop; other site 266835010110 H-loop/switch region; other site 266835010111 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 266835010112 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 266835010113 Walker A/P-loop; other site 266835010114 ATP binding site [chemical binding]; other site 266835010115 Q-loop/lid; other site 266835010116 ABC transporter signature motif; other site 266835010117 Walker B; other site 266835010118 D-loop; other site 266835010119 H-loop/switch region; other site 266835010120 FtsX-like permease family; Region: FtsX; pfam02687 266835010121 Protein of unknown function (DUF1344); Region: DUF1344; pfam07076 266835010122 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 266835010123 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 266835010124 AsnC family; Region: AsnC_trans_reg; pfam01037 266835010125 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 266835010126 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835010127 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 266835010128 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 266835010129 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 266835010130 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 266835010131 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 266835010132 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 266835010133 E3 interaction surface; other site 266835010134 lipoyl attachment site [posttranslational modification]; other site 266835010135 e3 binding domain; Region: E3_binding; pfam02817 266835010136 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 266835010137 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 266835010138 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 266835010139 alpha subunit interface [polypeptide binding]; other site 266835010140 TPP binding site [chemical binding]; other site 266835010141 heterodimer interface [polypeptide binding]; other site 266835010142 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 266835010143 2-oxoisovalerate dehydrogenase E1 alpha subunit N terminal; Region: OxoDH_E1alpha_N; pfam12573 266835010144 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 266835010145 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 266835010146 tetramer interface [polypeptide binding]; other site 266835010147 TPP-binding site [chemical binding]; other site 266835010148 heterodimer interface [polypeptide binding]; other site 266835010149 phosphorylation loop region [posttranslational modification] 266835010150 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK06585 266835010151 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 266835010152 Uncharacterized conserved protein [Function unknown]; Region: COG5588 266835010153 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 266835010154 ParB-like nuclease domain; Region: ParBc; pfam02195 266835010155 KorB domain; Region: KorB; pfam08535 266835010156 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 266835010157 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 266835010158 P-loop; other site 266835010159 Magnesium ion binding site [ion binding]; other site 266835010160 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 266835010161 Magnesium ion binding site [ion binding]; other site 266835010162 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 266835010163 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 266835010164 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 266835010165 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 266835010166 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 266835010167 Predicted GTPase [General function prediction only]; Region: ThdF; COG0486 266835010168 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 266835010169 trmE is a tRNA modification GTPase; Region: trmE; cd04164 266835010170 G1 box; other site 266835010171 GTP/Mg2+ binding site [chemical binding]; other site 266835010172 Switch I region; other site 266835010173 G2 box; other site 266835010174 Switch II region; other site 266835010175 G3 box; other site 266835010176 G4 box; other site 266835010177 G5 box; other site 266835010178 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 266835010179 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 266835010180 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 266835010181 catalytic residues [active] 266835010182 transcription termination factor Rho; Provisional; Region: rho; PRK09376 266835010183 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 266835010184 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 266835010185 RNA binding site [nucleotide binding]; other site 266835010186 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 266835010187 multimer interface [polypeptide binding]; other site 266835010188 Walker A motif; other site 266835010189 ATP binding site [chemical binding]; other site 266835010190 Walker B motif; other site 266835010191 Predicted membrane protein [Function unknown]; Region: COG1981 266835010192 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 266835010193 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 266835010194 substrate binding site [chemical binding]; other site 266835010195 active site 266835010196 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1806 266835010197 Maf-like protein; Region: Maf; pfam02545 266835010198 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 266835010199 active site 266835010200 dimer interface [polypeptide binding]; other site 266835010201 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 266835010202 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 266835010203 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 266835010204 shikimate binding site; other site 266835010205 NAD(P) binding site [chemical binding]; other site 266835010206 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 266835010207 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 266835010208 CoA-binding site [chemical binding]; other site 266835010209 ATP-binding [chemical binding]; other site 266835010210 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 266835010211 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 266835010212 active site 266835010213 catalytic site [active] 266835010214 substrate binding site [chemical binding]; other site 266835010215 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 266835010216 N-carbamoylsarcosine amidohydrolase (CSHase) hydrolyzes N-carbamoylsarcosine to sarcosine, carbon dioxide and ammonia. CSHase is involved in one of the two alternative pathways for creatinine degradation to glycine in microorganisms.This...; Region: CSHase; cd01015 266835010217 Isochorismatase family; Region: Isochorismatase; pfam00857 266835010218 catalytic triad [active] 266835010219 substrate binding site [chemical binding]; other site 266835010220 domain interfaces; other site 266835010221 conserved cis-peptide bond; other site 266835010222 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 266835010223 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 266835010224 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 266835010225 active site 266835010226 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 266835010227 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 266835010228 conserved cys residue [active] 266835010229 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266835010230 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 266835010231 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 266835010232 homodimer interface [polypeptide binding]; other site 266835010233 substrate-cofactor binding pocket; other site 266835010234 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266835010235 catalytic residue [active] 266835010236 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 266835010237 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 266835010238 dimer interface [polypeptide binding]; other site 266835010239 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266835010240 catalytic residue [active] 266835010241 FOG: CBS domain [General function prediction only]; Region: COG0517 266835010242 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 266835010243 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 266835010244 homotrimer interaction site [polypeptide binding]; other site 266835010245 putative active site [active] 266835010246 Isochorismatase family; Region: Isochorismatase; pfam00857 266835010247 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 266835010248 catalytic triad [active] 266835010249 conserved cis-peptide bond; other site 266835010250 Predicted transcriptional regulators [Transcription]; Region: COG1733 266835010251 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 266835010252 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 266835010253 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 266835010254 potential catalytic triad [active] 266835010255 conserved cys residue [active] 266835010256 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 266835010257 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 266835010258 Rrf2 family protein; Region: rrf2_super; TIGR00738 266835010259 Transcriptional regulator; Region: Rrf2; pfam02082 266835010260 ABC-type taurine transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: TauA; COG4521 266835010261 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 266835010262 substrate binding pocket [chemical binding]; other site 266835010263 ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427 266835010264 ABC-type taurine transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG4525 266835010265 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 266835010266 Walker A/P-loop; other site 266835010267 ATP binding site [chemical binding]; other site 266835010268 Q-loop/lid; other site 266835010269 ABC transporter signature motif; other site 266835010270 Walker B; other site 266835010271 D-loop; other site 266835010272 H-loop/switch region; other site 266835010273 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 266835010274 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835010275 dimer interface [polypeptide binding]; other site 266835010276 conserved gate region; other site 266835010277 putative PBP binding loops; other site 266835010278 ABC-ATPase subunit interface; other site 266835010279 ABC-2 type transporter; Region: ABC2_membrane; cl17235 266835010280 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 266835010281 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 266835010282 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 266835010283 Walker A/P-loop; other site 266835010284 ATP binding site [chemical binding]; other site 266835010285 Q-loop/lid; other site 266835010286 ABC transporter signature motif; other site 266835010287 Walker B; other site 266835010288 D-loop; other site 266835010289 H-loop/switch region; other site 266835010290 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 266835010291 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 266835010292 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 266835010293 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 266835010294 Predicted ATPase [General function prediction only]; Region: COG3899 266835010295 AAA ATPase domain; Region: AAA_16; pfam13191 266835010296 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 266835010297 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266835010298 DNA binding residues [nucleotide binding] 266835010299 Protein of unknown function (DUF4242); Region: DUF4242; pfam14026 266835010300 methionine sulfoxide reductase A; Provisional; Region: PRK13014 266835010301 Uncharacterized secreted protein [Function unknown]; Region: COG5429 266835010302 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 266835010303 Putative Flp pilus-assembly TadE/G-like; Region: Tad; pfam13400 266835010304 GTP-binding protein LepA; Provisional; Region: PRK05433 266835010305 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 266835010306 G1 box; other site 266835010307 putative GEF interaction site [polypeptide binding]; other site 266835010308 GTP/Mg2+ binding site [chemical binding]; other site 266835010309 Switch I region; other site 266835010310 G2 box; other site 266835010311 G3 box; other site 266835010312 Switch II region; other site 266835010313 G4 box; other site 266835010314 G5 box; other site 266835010315 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 266835010316 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 266835010317 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 266835010318 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 266835010319 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 266835010320 Preprotein translocase subunit SecB [Intracellular trafficking and secretion]; Region: SecB; COG1952 266835010321 SecA binding site; other site 266835010322 Preprotein binding site; other site 266835010323 Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030 266835010324 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4395 266835010325 Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821 266835010326 MltA specific insert domain; Region: MltA; smart00925 266835010327 3D domain; Region: 3D; pfam06725 266835010328 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 266835010329 Smr domain; Region: Smr; pfam01713 266835010330 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 266835010331 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266835010332 non-specific DNA binding site [nucleotide binding]; other site 266835010333 salt bridge; other site 266835010334 sequence-specific DNA binding site [nucleotide binding]; other site 266835010335 Bacterial transglutaminase-like cysteine proteinase BTLCP; Region: BTLCP; pfam06035 266835010336 Poly-beta-hydroxyalkanoate depolymerase [Lipid metabolism]; Region: DepA; COG4553 266835010337 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 266835010338 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 266835010339 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 266835010340 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 266835010341 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 266835010342 Walker A/P-loop; other site 266835010343 ATP binding site [chemical binding]; other site 266835010344 Q-loop/lid; other site 266835010345 ABC transporter signature motif; other site 266835010346 Walker B; other site 266835010347 D-loop; other site 266835010348 H-loop/switch region; other site 266835010349 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 266835010350 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835010351 dimer interface [polypeptide binding]; other site 266835010352 conserved gate region; other site 266835010353 ABC-ATPase subunit interface; other site 266835010354 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 266835010355 alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565 266835010356 active site 266835010357 dimer interface [polypeptide binding]; other site 266835010358 non-prolyl cis peptide bond; other site 266835010359 insertion regions; other site 266835010360 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 266835010361 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 266835010362 substrate binding pocket [chemical binding]; other site 266835010363 ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427 266835010364 Uncharacterized conserved protein [Function unknown]; Region: COG2898 266835010365 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 266835010366 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 266835010367 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 266835010368 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 266835010369 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 266835010370 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266835010371 active site 266835010372 phosphorylation site [posttranslational modification] 266835010373 intermolecular recognition site; other site 266835010374 dimerization interface [polypeptide binding]; other site 266835010375 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266835010376 DNA binding residues [nucleotide binding] 266835010377 dimerization interface [polypeptide binding]; other site 266835010378 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 266835010379 Histidine kinase; Region: HisKA_3; pfam07730 266835010380 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266835010381 ATP binding site [chemical binding]; other site 266835010382 Mg2+ binding site [ion binding]; other site 266835010383 G-X-G motif; other site 266835010384 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 266835010385 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 266835010386 active site 266835010387 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 266835010388 sequence-specific DNA binding site [nucleotide binding]; other site 266835010389 salt bridge; other site 266835010390 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 266835010391 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 266835010392 Sulfate transporter family; Region: Sulfate_transp; pfam00916 266835010393 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 266835010394 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 266835010395 Haloacid dehalogenase superfamily, subfamily IA, variant 2 with 3rd motif like haloacid dehalogenase; Region: HAD-SF-IA-v2; TIGR01493 266835010396 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 266835010397 EamA-like transporter family; Region: EamA; pfam00892 266835010398 EamA-like transporter family; Region: EamA; pfam00892 266835010399 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266835010400 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266835010401 LysR substrate binding domain; Region: LysR_substrate; pfam03466 266835010402 dimerization interface [polypeptide binding]; other site 266835010403 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 266835010404 active site 266835010405 DNA binding site [nucleotide binding] 266835010406 SnoaL-like domain; Region: SnoaL_2; pfam12680 266835010407 Uncharacterized conserved protein [Function unknown]; Region: COG3391 266835010408 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 266835010409 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266835010410 non-specific DNA binding site [nucleotide binding]; other site 266835010411 salt bridge; other site 266835010412 sequence-specific DNA binding site [nucleotide binding]; other site 266835010413 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 266835010414 cyclase homology domain; Region: CHD; cd07302 266835010415 nucleotidyl binding site; other site 266835010416 metal binding site [ion binding]; metal-binding site 266835010417 dimer interface [polypeptide binding]; other site 266835010418 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 266835010419 CHAD domain; Region: CHAD; pfam05235 266835010420 CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891 266835010421 putative active site [active] 266835010422 putative metal binding residues [ion binding]; other site 266835010423 signature motif; other site 266835010424 putative dimer interface [polypeptide binding]; other site 266835010425 putative phosphate binding site [ion binding]; other site 266835010426 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266835010427 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 266835010428 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 266835010429 HlyD family secretion protein; Region: HlyD_3; pfam13437 266835010430 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 266835010431 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 266835010432 Walker A/P-loop; other site 266835010433 ATP binding site [chemical binding]; other site 266835010434 Q-loop/lid; other site 266835010435 ABC transporter signature motif; other site 266835010436 Walker B; other site 266835010437 D-loop; other site 266835010438 H-loop/switch region; other site 266835010439 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 266835010440 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 266835010441 ABC-2 type transporter; Region: ABC2_membrane; cl17235 266835010442 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 266835010443 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 266835010444 tetramer interface [polypeptide binding]; other site 266835010445 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266835010446 catalytic residue [active] 266835010447 Uncharacterized conserved protein [Function unknown]; Region: COG1633 266835010448 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 266835010449 diiron binding motif [ion binding]; other site 266835010450 Uncharacterized conserved protein [Function unknown]; Region: COG1633 266835010451 CCC1-related protein family; Region: CCC1_like_1; cd02437 266835010452 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 266835010453 NIPSNAP; Region: NIPSNAP; pfam07978 266835010454 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266835010455 dimerization interface [polypeptide binding]; other site 266835010456 putative DNA binding site [nucleotide binding]; other site 266835010457 putative Zn2+ binding site [ion binding]; other site 266835010458 ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK05972 266835010459 DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777 266835010460 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 266835010461 active site 266835010462 DNA binding site [nucleotide binding] 266835010463 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 266835010464 DNA binding site [nucleotide binding] 266835010465 PaeLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: PaeLigD_Pol_like; cd04862 266835010466 nucleotide binding site [chemical binding]; other site 266835010467 Ku-homolog [Replication, recombination, and repair]; Region: COG1273 266835010468 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 266835010469 putative DNA binding site [nucleotide binding]; other site 266835010470 putative homodimer interface [polypeptide binding]; other site 266835010471 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 266835010472 dimerization interface [polypeptide binding]; other site 266835010473 metal binding site [ion binding]; metal-binding site 266835010474 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 266835010475 homotrimer interaction site [polypeptide binding]; other site 266835010476 putative active site [active] 266835010477 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 266835010478 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 266835010479 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 266835010480 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 266835010481 C-terminal domain interface [polypeptide binding]; other site 266835010482 GSH binding site (G-site) [chemical binding]; other site 266835010483 dimer interface [polypeptide binding]; other site 266835010484 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 266835010485 dimer interface [polypeptide binding]; other site 266835010486 N-terminal domain interface [polypeptide binding]; other site 266835010487 substrate binding pocket (H-site) [chemical binding]; other site 266835010488 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 266835010489 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 266835010490 dimer interface [polypeptide binding]; other site 266835010491 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266835010492 catalytic residue [active] 266835010493 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 266835010494 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 266835010495 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 266835010496 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 266835010497 ribonuclease PH; Reviewed; Region: rph; PRK00173 266835010498 Ribonuclease PH; Region: RNase_PH_bact; cd11362 266835010499 hexamer interface [polypeptide binding]; other site 266835010500 active site 266835010501 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_13; cd08354 266835010502 putative metal binding site [ion binding]; other site 266835010503 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266835010504 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 266835010505 active site 266835010506 dimerization interface [polypeptide binding]; other site 266835010507 coproporphyrinogen III oxidase; Provisional; Region: PRK09057 266835010508 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 266835010509 FeS/SAM binding site; other site 266835010510 HemN C-terminal domain; Region: HemN_C; pfam06969 266835010511 Predicted protein tyrosine phosphatase [General function prediction only]; Region: COG4551 266835010512 Predicted methyltransferases [General function prediction only]; Region: COG0313 266835010513 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 266835010514 putative SAM binding site [chemical binding]; other site 266835010515 putative homodimer interface [polypeptide binding]; other site 266835010516 hypothetical protein; Reviewed; Region: PRK12497 266835010517 Undecaprenyl pyrophosphate phosphatase [Lipid transport and metabolism]; Region: BacA; COG1968 266835010518 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 266835010519 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 266835010520 C-terminal domain interface [polypeptide binding]; other site 266835010521 GSH binding site (G-site) [chemical binding]; other site 266835010522 dimer interface [polypeptide binding]; other site 266835010523 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 266835010524 N-terminal domain interface [polypeptide binding]; other site 266835010525 dimer interface [polypeptide binding]; other site 266835010526 substrate binding pocket (H-site) [chemical binding]; other site 266835010527 epoxyqueuosine reductase; Region: TIGR00276 266835010528 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 266835010529 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 266835010530 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 266835010531 putative NAD(P) binding site [chemical binding]; other site 266835010532 penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429 266835010533 Murein endopeptidase [Cell envelope biogenesis, outer membrane]; Region: MepA; COG3770 266835010534 Glucokinase [Carbohydrate transport and metabolism]; Region: Glk; COG0837 266835010535 glucokinase, proteobacterial type; Region: glk; TIGR00749 266835010536 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 266835010537 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 266835010538 ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins; Region: ABC_MTABC3_MDL1_MDL2; cd03249 266835010539 Walker A/P-loop; other site 266835010540 ATP binding site [chemical binding]; other site 266835010541 Q-loop/lid; other site 266835010542 ABC transporter signature motif; other site 266835010543 Walker B; other site 266835010544 D-loop; other site 266835010545 H-loop/switch region; other site 266835010546 Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289 266835010547 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 266835010548 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 266835010549 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 266835010550 catalytic core [active] 266835010551 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 266835010552 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 266835010553 Zn-finger in ubiquitin-hydrolases and other protein; Region: zf-UBP; pfam02148 266835010554 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 266835010555 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 266835010556 Predicted integral membrane protein [Function unknown]; Region: COG5616 266835010557 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266835010558 binding surface 266835010559 TPR motif; other site 266835010560 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 266835010561 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 266835010562 dimer interface [polypeptide binding]; other site 266835010563 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266835010564 catalytic residue [active] 266835010565 tyrosine decarboxylase; Region: PLN02880 266835010566 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 266835010567 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266835010568 catalytic residue [active] 266835010569 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266835010570 DNA binding site [nucleotide binding] 266835010571 Predicted integral membrane protein [Function unknown]; Region: COG5616 266835010572 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 266835010573 TPR motif; other site 266835010574 binding surface 266835010575 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266835010576 TPR motif; other site 266835010577 binding surface 266835010578 Uncharacterized conserved small protein [Function unknown]; Region: COG5457 266835010579 Uncharacterized conserved protein [Function unknown]; Region: COG3592 266835010580 Zinc finger domain containing protein (CDGSH-type) [Function unknown]; Region: COG3369 266835010581 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 266835010582 Zinc finger domain containing protein (CDGSH-type) [Function unknown]; Region: COG3369 266835010583 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 266835010584 Plastocyanin [Energy production and conversion]; Region: PetE; COG3794 266835010585 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 266835010586 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 266835010587 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 266835010588 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 266835010589 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 266835010590 Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728 266835010591 active site 266835010592 Short repeat of unknown function (DUF308); Region: DUF308; pfam03729 266835010593 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266835010594 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266835010595 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 266835010596 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266835010597 Walker A motif; other site 266835010598 ATP binding site [chemical binding]; other site 266835010599 Walker B motif; other site 266835010600 arginine finger; other site 266835010601 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 266835010602 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 266835010603 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 266835010604 catalytic residues [active] 266835010605 catalytic nucleophile [active] 266835010606 Recombinase; Region: Recombinase; pfam07508 266835010607 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 266835010608 DnaJ-domain-containing proteins 1 [Posttranslational modification, protein turnover, chaperones]; Region: DjlA; COG1076 266835010609 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 266835010610 HSP70 interaction site [polypeptide binding]; other site 266835010611 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 266835010612 Acyltransferase family; Region: Acyl_transf_3; pfam01757 266835010613 Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616 266835010614 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 266835010615 active site 266835010616 DNA polymerase; Provisional; Region: PHA02563 266835010617 MeCP2, MBD1, MBD2, MBD3, MBD4, CLLD8-like, and BAZ2A-like proteins constitute a family of proteins that share the methyl-CpG-binding domain (MBD). The MBD consists of about 70 residues and is defined as the minimal region required for binding to...; Region: MBD; cl00110 266835010618 DNA binding site [nucleotide binding] 266835010619 Predicted periplasmic protein [Function unknown]; Region: COG3904 266835010620 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266835010621 dimerization interface [polypeptide binding]; other site 266835010622 putative DNA binding site [nucleotide binding]; other site 266835010623 putative Zn2+ binding site [ion binding]; other site 266835010624 Predicted transcriptional regulator [Transcription]; Region: COG4957 266835010625 Uncharacterized conserved protein [Function unknown]; Region: COG3422 266835010626 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 266835010627 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266835010628 active site 266835010629 phosphorylation site [posttranslational modification] 266835010630 intermolecular recognition site; other site 266835010631 dimerization interface [polypeptide binding]; other site 266835010632 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266835010633 DNA binding residues [nucleotide binding] 266835010634 dimerization interface [polypeptide binding]; other site 266835010635 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266835010636 dimer interface [polypeptide binding]; other site 266835010637 phosphorylation site [posttranslational modification] 266835010638 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266835010639 ATP binding site [chemical binding]; other site 266835010640 Mg2+ binding site [ion binding]; other site 266835010641 G-X-G motif; other site 266835010642 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952 266835010643 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 266835010644 Protein of unknown function (DUF768); Region: DUF768; pfam05589 266835010645 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 266835010646 trimer interface [polypeptide binding]; other site 266835010647 active site 266835010648 substrate binding site [chemical binding]; other site 266835010649 CoA binding site [chemical binding]; other site 266835010650 ATP-dependent DNA ligase [DNA replication, recombination, and repair]; Region: CDC9; COG1793 266835010651 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 266835010652 Bacteriophage protein gp37 [Function unknown]; Region: COG4422 266835010653 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 266835010654 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 266835010655 catalytic residues [active] 266835010656 catalytic nucleophile [active] 266835010657 Recombinase; Region: Recombinase; pfam07508 266835010658 Predicted flavoprotein [General function prediction only]; Region: COG0431 266835010659 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 266835010660 Uncharacterized copper-binding protein [Inorganic ion transport and metabolism]; Region: COG4454 266835010661 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 266835010662 Domain of unknown function DUF20; Region: UPF0118; pfam01594 266835010663 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952 266835010664 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 266835010665 Predicted membrane protein [Function unknown]; Region: COG2261 266835010666 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3753 266835010667 Bacterial lipocalin [Cell envelope biogenesis, outer membrane]; Region: Blc; COG3040 266835010668 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 266835010669 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 266835010670 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 266835010671 putative dimer interface [polypeptide binding]; other site 266835010672 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 266835010673 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 266835010674 putative dimer interface [polypeptide binding]; other site 266835010675 Flavodoxin [Energy production and conversion / Coenzyme metabolism]; Region: HemG; COG4635 266835010676 Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467 266835010677 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 266835010678 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 266835010679 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 266835010680 NAD binding site [chemical binding]; other site 266835010681 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 266835010682 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 266835010683 active site 266835010684 substrate binding site [chemical binding]; other site 266835010685 FMN binding site [chemical binding]; other site 266835010686 putative catalytic residues [active] 266835010687 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 266835010688 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 266835010689 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 266835010690 glutathione synthetase; Provisional; Region: PRK05246 266835010691 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 266835010692 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 266835010693 glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182 266835010694 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 266835010695 Ligand binding site; other site 266835010696 Putative Catalytic site; other site 266835010697 DXD motif; other site 266835010698 Predicted membrane protein [Function unknown]; Region: COG2246 266835010699 GtrA-like protein; Region: GtrA; pfam04138 266835010700 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 266835010701 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266835010702 metal binding site [ion binding]; metal-binding site 266835010703 active site 266835010704 I-site; other site 266835010705 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 266835010706 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 266835010707 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 266835010708 short chain dehydrogenase; Provisional; Region: PRK12939 266835010709 classical (c) SDRs; Region: SDR_c; cd05233 266835010710 NAD(P) binding site [chemical binding]; other site 266835010711 active site 266835010712 2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140 266835010713 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 266835010714 active site 266835010715 intersubunit interface [polypeptide binding]; other site 266835010716 catalytic residue [active] 266835010717 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 266835010718 ATP-grasp domain; Region: ATP-grasp_4; cl17255 266835010719 Predicted metal-dependent enzyme of the double-stranded beta helix superfamily [General function prediction only]; Region: COG5553 266835010720 Transcriptional regulators [Transcription]; Region: GntR; COG1802 266835010721 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266835010722 DNA-binding site [nucleotide binding]; DNA binding site 266835010723 FCD domain; Region: FCD; pfam07729 266835010724 Uncharacterized conserved protein [Function unknown]; Region: COG5470 266835010725 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 266835010726 active site 266835010727 dimer interface [polypeptide binding]; other site 266835010728 Predicted flavoprotein [General function prediction only]; Region: COG0431 266835010729 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 266835010730 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266835010731 S-adenosylmethionine binding site [chemical binding]; other site 266835010732 chaperone protein DnaJ; Provisional; Region: PRK10767 266835010733 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 266835010734 HSP70 interaction site [polypeptide binding]; other site 266835010735 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 266835010736 substrate binding site [polypeptide binding]; other site 266835010737 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 266835010738 Zn binding sites [ion binding]; other site 266835010739 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 266835010740 dimer interface [polypeptide binding]; other site 266835010741 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 266835010742 Nucleotide-binding domain of human HSPA9, Escherichia coli DnaK, and similar proteins; Region: HSPA9-like_NBD; cd11733 266835010743 nucleotide binding site [chemical binding]; other site 266835010744 NEF interaction site [polypeptide binding]; other site 266835010745 SBD interface [polypeptide binding]; other site 266835010746 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 266835010747 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 266835010748 substrate binding site [chemical binding]; other site 266835010749 hexamer interface [polypeptide binding]; other site 266835010750 metal binding site [ion binding]; metal-binding site 266835010751 Transcriptional regulators [Transcription]; Region: GntR; COG1802 266835010752 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266835010753 DNA-binding site [nucleotide binding]; DNA binding site 266835010754 FCD domain; Region: FCD; pfam07729 266835010755 malonyl-CoA synthase; Validated; Region: PRK07514 266835010756 Malonyl-CoA synthetase (MCS); Region: MCS; cd05941 266835010757 acyl-activating enzyme (AAE) consensus motif; other site 266835010758 active site 266835010759 AMP binding site [chemical binding]; other site 266835010760 CoA binding site [chemical binding]; other site 266835010761 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 266835010762 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 266835010763 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 266835010764 hydroxyglutarate oxidase; Provisional; Region: PRK11728 266835010765 Predicted dehydrogenase [General function prediction only]; Region: COG0579 266835010766 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 266835010767 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 266835010768 active site 266835010769 dimer interface [polypeptide binding]; other site 266835010770 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 266835010771 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 266835010772 dimer interface [polypeptide binding]; other site 266835010773 active site 266835010774 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 266835010775 dimer interface [polypeptide binding]; other site 266835010776 active site 266835010777 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 266835010778 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266835010779 DNA-binding site [nucleotide binding]; DNA binding site 266835010780 UTRA domain; Region: UTRA; pfam07702 266835010781 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 266835010782 nucleotide binding site [chemical binding]; other site 266835010783 Predicted sugar phosphate isomerase [General function prediction only]; Region: COG2103 266835010784 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 266835010785 putative active site [active] 266835010786 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 266835010787 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 266835010788 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 266835010789 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835010790 dimer interface [polypeptide binding]; other site 266835010791 conserved gate region; other site 266835010792 putative PBP binding loops; other site 266835010793 ABC-ATPase subunit interface; other site 266835010794 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 266835010795 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835010796 dimer interface [polypeptide binding]; other site 266835010797 conserved gate region; other site 266835010798 putative PBP binding loops; other site 266835010799 ABC-ATPase subunit interface; other site 266835010800 Domain of unknown function (DUF4304); Region: DUF4304; pfam14137 266835010801 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 266835010802 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 266835010803 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 266835010804 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 266835010805 Walker A/P-loop; other site 266835010806 ATP binding site [chemical binding]; other site 266835010807 Q-loop/lid; other site 266835010808 ABC transporter signature motif; other site 266835010809 Walker B; other site 266835010810 D-loop; other site 266835010811 H-loop/switch region; other site 266835010812 TOBE domain; Region: TOBE_2; pfam08402 266835010813 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 266835010814 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 266835010815 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 266835010816 human DHRS6-like, classical (c) SDRs; Region: DHRS6_like_SDR_c; cd05368 266835010817 NAD binding site [chemical binding]; other site 266835010818 homotetramer interface [polypeptide binding]; other site 266835010819 homodimer interface [polypeptide binding]; other site 266835010820 active site 266835010821 Aldehyde dehydrogenase family 16A1-like; Region: ALDH_F16; cd07111 266835010822 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 266835010823 NAD(P) binding site [chemical binding]; other site 266835010824 catalytic residues [active] 266835010825 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 266835010826 NAD(P) binding site [chemical binding]; other site 266835010827 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 266835010828 intersubunit interface [polypeptide binding]; other site 266835010829 active site 266835010830 catalytic residue [active] 266835010831 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 266835010832 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 266835010833 FAD binding pocket [chemical binding]; other site 266835010834 FAD binding motif [chemical binding]; other site 266835010835 phosphate binding motif [ion binding]; other site 266835010836 beta-alpha-beta structure motif; other site 266835010837 NAD binding pocket [chemical binding]; other site 266835010838 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 266835010839 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 266835010840 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 266835010841 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 266835010842 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 266835010843 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 266835010844 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 266835010845 substrate binding pocket [chemical binding]; other site 266835010846 membrane-bound complex binding site; other site 266835010847 hinge residues; other site 266835010848 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 266835010849 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 266835010850 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835010851 dimer interface [polypeptide binding]; other site 266835010852 conserved gate region; other site 266835010853 ABC-ATPase subunit interface; other site 266835010854 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 266835010855 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 266835010856 Walker A/P-loop; other site 266835010857 ATP binding site [chemical binding]; other site 266835010858 Q-loop/lid; other site 266835010859 ABC transporter signature motif; other site 266835010860 Walker B; other site 266835010861 D-loop; other site 266835010862 H-loop/switch region; other site 266835010863 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 266835010864 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 266835010865 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 266835010866 homoprotocatechuate degradation operon regulator, HpaR; Region: HpaR; TIGR02337 266835010867 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 266835010868 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266835010869 Glycoside hydrolase families 71, 99, and related domains; Region: GH99_GH71_like; cl01529 266835010870 putative catalytic site [active] 266835010871 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 266835010872 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 266835010873 Lipopolysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: RgpF; COG3754 266835010874 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 266835010875 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 266835010876 Probable Catalytic site; other site 266835010877 metal-binding site 266835010878 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3755 266835010879 Ketopantoate reductase [Coenzyme metabolism]; Region: ApbA; COG1893 266835010880 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 266835010881 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 266835010882 Coenzyme A binding pocket [chemical binding]; other site 266835010883 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 266835010884 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266835010885 ATP binding site [chemical binding]; other site 266835010886 Mg2+ binding site [ion binding]; other site 266835010887 G-X-G motif; other site 266835010888 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 266835010889 ribonuclease P; Reviewed; Region: rnpA; PRK01313 266835010890 membrane protein insertase; Provisional; Region: PRK01318 266835010891 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 266835010892 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 266835010893 Fasciclin domain; Region: Fasciclin; pfam02469 266835010894 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 266835010895 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 266835010896 trimer interface [polypeptide binding]; other site 266835010897 active site 266835010898 substrate binding site [chemical binding]; other site 266835010899 CoA binding site [chemical binding]; other site 266835010900 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 266835010901 G1 box; other site 266835010902 GTP/Mg2+ binding site [chemical binding]; other site 266835010903 Switch I region; other site 266835010904 G2 box; other site 266835010905 G3 box; other site 266835010906 Switch II region; other site 266835010907 G4 box; other site 266835010908 G5 box; other site 266835010909 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266835010910 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266835010911 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 266835010912 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 266835010913 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 266835010914 HlyD family secretion protein; Region: HlyD_3; pfam13437 266835010915 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 266835010916 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266835010917 putative substrate translocation pore; other site 266835010918 methionine sulfoxide reductase B; Provisional; Region: PRK00222 266835010919 SelR domain; Region: SelR; pfam01641 266835010920 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 266835010921 Fasciclin domain; Region: Fasciclin; pfam02469 266835010922 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5343 266835010923 Anti-sigma-K factor rskA; Region: RskA; pfam10099 266835010924 RNA polymerase sigma factor; Provisional; Region: PRK12514 266835010925 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 266835010926 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 266835010927 DNA binding residues [nucleotide binding] 266835010928 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 266835010929 Amidase; Region: Amidase; cl11426 266835010930 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 266835010931 homohexameric interface [polypeptide binding]; other site 266835010932 feedback inhibition sensing region; other site 266835010933 nucleotide binding site [chemical binding]; other site 266835010934 N-acetyl-L-glutamate binding site [chemical binding]; other site 266835010935 YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgH_like; cd02198 266835010936 homotrimer interaction site [polypeptide binding]; other site 266835010937 putative active site [active] 266835010938 magnesium-protoporphyrin IX monomethyl ester anaerobic oxidative cyclase; Region: BchE; TIGR02026 266835010939 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 266835010940 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 266835010941 FeS/SAM binding site; other site 266835010942 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 266835010943 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266835010944 putative DNA binding site [nucleotide binding]; other site 266835010945 putative Zn2+ binding site [ion binding]; other site 266835010946 AsnC family; Region: AsnC_trans_reg; pfam01037 266835010947 Prokaryotic phenylalanine-4-hydroxylase (pro_PheOH); a member of the biopterin-dependent aromatic amino acid hydroxylase family of non-heme, iron(II)-dependent enzymes that also includes the eukaryotic proteins, phenylalanine-4-hydroxylase (eu_PheOH); Region: pro_PheOH; cd03348 266835010948 cofactor binding site; other site 266835010949 metal binding site [ion binding]; metal-binding site 266835010950 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 266835010951 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266835010952 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266835010953 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266835010954 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 266835010955 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 266835010956 MarR family; Region: MarR; pfam01047 266835010957 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 266835010958 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 266835010959 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 266835010960 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 266835010961 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 266835010962 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 266835010963 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266835010964 metal binding site [ion binding]; metal-binding site 266835010965 active site 266835010966 I-site; other site 266835010967 pyrimidine 5'-nucleotidase; Region: Pyr-5-nucltdase; TIGR01993 266835010968 ?-D-glucose-1-phosphatase; Provisional; Region: PRK09456 266835010969 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 266835010970 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 266835010971 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 266835010972 trimer interface [polypeptide binding]; other site 266835010973 active site 266835010974 substrate binding site [chemical binding]; other site 266835010975 CoA binding site [chemical binding]; other site 266835010976 Predicted membrane protein [Function unknown]; Region: COG3152 266835010977 Predicted membrane protein [Function unknown]; Region: COG3152 266835010978 2-dehydropantoate 2-reductase; Provisional; Region: PRK08229 266835010979 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 266835010980 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 266835010981 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 266835010982 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 266835010983 metal binding site [ion binding]; metal-binding site 266835010984 dimer interface [polypeptide binding]; other site 266835010985 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 266835010986 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 266835010987 dimerization interface 3.5A [polypeptide binding]; other site 266835010988 active site 266835010989 Predicted acetyltransferase [General function prediction only]; Region: COG3153 266835010990 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 266835010991 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 266835010992 putative active site [active] 266835010993 substrate binding site [chemical binding]; other site 266835010994 putative cosubstrate binding site; other site 266835010995 catalytic site [active] 266835010996 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 266835010997 substrate binding site [chemical binding]; other site 266835010998 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 266835010999 active site 266835011000 catalytic residues [active] 266835011001 metal binding site [ion binding]; metal-binding site 266835011002 Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322 266835011003 RmuC family; Region: RmuC; pfam02646 266835011004 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266835011005 S-adenosylmethionine binding site [chemical binding]; other site 266835011006 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 266835011007 Uncharacterized conserved protein [Function unknown]; Region: COG3791 266835011008 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 266835011009 Cation efflux family; Region: Cation_efflux; pfam01545 266835011010 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 266835011011 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 266835011012 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 266835011013 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 266835011014 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 266835011015 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 266835011016 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 266835011017 Domain of unknown function DUF20; Region: UPF0118; pfam01594 266835011018 Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162 266835011019 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 266835011020 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 266835011021 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 266835011022 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 266835011023 Bacterial family of Mg++ dependent phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate inositol monophosphate or similar substrates; Region: Bacterial_IMPase_like_2; cd01643 266835011024 active site 266835011025 MarR family; Region: MarR_2; cl17246 266835011026 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 266835011027 Amino acid synthesis; Region: AA_synth; pfam06684 266835011028 Uncharacterized conserved protein [Function unknown]; Region: COG2122 266835011029 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 266835011030 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 266835011031 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 266835011032 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 266835011033 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 266835011034 Isochorismatase family; Region: Isochorismatase; pfam00857 266835011035 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 266835011036 catalytic triad [active] 266835011037 metal binding site [ion binding]; metal-binding site 266835011038 conserved cis-peptide bond; other site 266835011039 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 266835011040 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 266835011041 transmembrane helices; other site 266835011042 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 266835011043 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 266835011044 Walker A/P-loop; other site 266835011045 ATP binding site [chemical binding]; other site 266835011046 Q-loop/lid; other site 266835011047 ABC transporter signature motif; other site 266835011048 Walker B; other site 266835011049 D-loop; other site 266835011050 H-loop/switch region; other site 266835011051 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 266835011052 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 266835011053 Walker A/P-loop; other site 266835011054 ATP binding site [chemical binding]; other site 266835011055 Q-loop/lid; other site 266835011056 ABC transporter signature motif; other site 266835011057 Walker B; other site 266835011058 D-loop; other site 266835011059 H-loop/switch region; other site 266835011060 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 266835011061 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 266835011062 TM-ABC transporter signature motif; other site 266835011063 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 266835011064 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 266835011065 TM-ABC transporter signature motif; other site 266835011066 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 266835011067 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 266835011068 ligand binding site [chemical binding]; other site 266835011069 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 266835011070 Nicotinic acid phosphoribosyltransferase [Coenzyme metabolism]; Region: PncB; COG1488 266835011071 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401 266835011072 active site 266835011073 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 266835011074 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266835011075 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266835011076 dimerization interface [polypeptide binding]; other site 266835011077 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 266835011078 agmatinase; Region: agmatinase; TIGR01230 266835011079 oligomer interface [polypeptide binding]; other site 266835011080 putative active site [active] 266835011081 Mn binding site [ion binding]; other site 266835011082 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 266835011083 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 266835011084 substrate binding pocket [chemical binding]; other site 266835011085 membrane-bound complex binding site; other site 266835011086 hinge residues; other site 266835011087 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835011088 dimer interface [polypeptide binding]; other site 266835011089 conserved gate region; other site 266835011090 putative PBP binding loops; other site 266835011091 ABC-ATPase subunit interface; other site 266835011092 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 266835011093 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835011094 dimer interface [polypeptide binding]; other site 266835011095 conserved gate region; other site 266835011096 putative PBP binding loops; other site 266835011097 ABC-ATPase subunit interface; other site 266835011098 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 266835011099 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266835011100 DNA gyrase inhibitor [DNA replication, recombination, and repair]; Region: COG3449 266835011101 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 266835011102 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 266835011103 Cytochrome c2 [Energy production and conversion]; Region: COG3474 266835011104 multidrug efflux protein; Reviewed; Region: PRK01766 266835011105 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 266835011106 cation binding site [ion binding]; other site 266835011107 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 266835011108 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266835011109 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266835011110 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 266835011111 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 266835011112 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 266835011113 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835011114 putative PBP binding loops; other site 266835011115 dimer interface [polypeptide binding]; other site 266835011116 ABC-ATPase subunit interface; other site 266835011117 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 266835011118 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835011119 dimer interface [polypeptide binding]; other site 266835011120 conserved gate region; other site 266835011121 putative PBP binding loops; other site 266835011122 ABC-ATPase subunit interface; other site 266835011123 L-idonate 5-dehydrogenase; Region: PLN02702 266835011124 Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285 266835011125 inhibitor binding site; inhibition site 266835011126 catalytic Zn binding site [ion binding]; other site 266835011127 structural Zn binding site [ion binding]; other site 266835011128 NADP binding site [chemical binding]; other site 266835011129 tetramer interface [polypeptide binding]; other site 266835011130 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 266835011131 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 266835011132 Walker A/P-loop; other site 266835011133 ATP binding site [chemical binding]; other site 266835011134 Q-loop/lid; other site 266835011135 ABC transporter signature motif; other site 266835011136 Walker B; other site 266835011137 D-loop; other site 266835011138 H-loop/switch region; other site 266835011139 TOBE domain; Region: TOBE; pfam03459 266835011140 Ribulose kinase [Energy production and conversion]; Region: AraB; COG1069 266835011141 Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_YpCarbK_like; cd07782 266835011142 N- and C-terminal domain interface [polypeptide binding]; other site 266835011143 active site 266835011144 MgATP binding site [chemical binding]; other site 266835011145 catalytic site [active] 266835011146 metal binding site [ion binding]; metal-binding site 266835011147 carbohydrate binding site [chemical binding]; other site 266835011148 putative homodimer interface [polypeptide binding]; other site 266835011149 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 266835011150 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 266835011151 motif II; other site 266835011152 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 266835011153 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 266835011154 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 266835011155 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 266835011156 sorbitol dehydrogenase; Provisional; Region: PRK07067 266835011157 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835011158 NAD(P) binding site [chemical binding]; other site 266835011159 active site 266835011160 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 266835011161 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 266835011162 Walker A/P-loop; other site 266835011163 ATP binding site [chemical binding]; other site 266835011164 Q-loop/lid; other site 266835011165 ABC transporter signature motif; other site 266835011166 Walker B; other site 266835011167 D-loop; other site 266835011168 H-loop/switch region; other site 266835011169 TOBE domain; Region: TOBE_2; pfam08402 266835011170 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 266835011171 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835011172 dimer interface [polypeptide binding]; other site 266835011173 conserved gate region; other site 266835011174 putative PBP binding loops; other site 266835011175 ABC-ATPase subunit interface; other site 266835011176 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835011177 putative PBP binding loops; other site 266835011178 dimer interface [polypeptide binding]; other site 266835011179 ABC-ATPase subunit interface; other site 266835011180 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 266835011181 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 266835011182 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 266835011183 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266835011184 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 266835011185 dimerization interface [polypeptide binding]; other site 266835011186 substrate binding pocket [chemical binding]; other site 266835011187 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 266835011188 MarR family; Region: MarR_2; pfam12802 266835011189 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 266835011190 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 266835011191 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 266835011192 motif II; other site 266835011193 hypothetical protein; Provisional; Region: PRK07490 266835011194 active site 266835011195 intersubunit interface [polypeptide binding]; other site 266835011196 Zn2+ binding site [ion binding]; other site 266835011197 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 266835011198 Protein of unknown function (DUF3995); Region: DUF3995; pfam13160 266835011199 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 266835011200 UreF; Region: UreF; pfam01730 266835011201 Urease accessory protein UreE [Posttranslational modification, protein turnover, chaperones]; Region: UreE; COG2371 266835011202 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 266835011203 dimer interface [polypeptide binding]; other site 266835011204 catalytic residues [active] 266835011205 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 266835011206 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 266835011207 putative C-terminal domain interface [polypeptide binding]; other site 266835011208 putative GSH binding site (G-site) [chemical binding]; other site 266835011209 putative dimer interface [polypeptide binding]; other site 266835011210 C-terminal, alpha helical domain of an unknown subfamily 8 of Glutathione S-transferases; Region: GST_C_8; cd03207 266835011211 dimer interface [polypeptide binding]; other site 266835011212 N-terminal domain interface [polypeptide binding]; other site 266835011213 putative substrate binding pocket (H-site) [chemical binding]; other site 266835011214 urease subunit alpha; Reviewed; Region: ureC; PRK13207 266835011215 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 266835011216 subunit interactions [polypeptide binding]; other site 266835011217 active site 266835011218 flap region; other site 266835011219 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 266835011220 gamma-beta subunit interface [polypeptide binding]; other site 266835011221 alpha-beta subunit interface [polypeptide binding]; other site 266835011222 HupE / UreJ protein; Region: HupE_UreJ; pfam04955 266835011223 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3813 266835011224 Protein of unknown function (DUF1272); Region: DUF1272; pfam06906 266835011225 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 266835011226 alpha-gamma subunit interface [polypeptide binding]; other site 266835011227 beta-gamma subunit interface [polypeptide binding]; other site 266835011228 Urease accessory protein UreH [Posttranslational modification, protein turnover, chaperones]; Region: UreH; COG0829 266835011229 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 266835011230 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 266835011231 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 266835011232 dimer interface [polypeptide binding]; other site 266835011233 active site 266835011234 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 266835011235 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 266835011236 C-terminal domain interface [polypeptide binding]; other site 266835011237 GSH binding site (G-site) [chemical binding]; other site 266835011238 dimer interface [polypeptide binding]; other site 266835011239 C-terminal, alpha helical domain of Ure2p and related Glutathione S-transferase-like proteins; Region: GST_C_Ure2p_like; cd03178 266835011240 dimer interface [polypeptide binding]; other site 266835011241 N-terminal domain interface [polypeptide binding]; other site 266835011242 nucleoside triphosphate hydrolase domain-containing protein; Reviewed; Region: PRK09270 266835011243 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 266835011244 active site 266835011245 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 266835011246 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 266835011247 Predicted membrane protein [Function unknown]; Region: COG4420 266835011248 Transcriptional regulators [Transcription]; Region: PurR; COG1609 266835011249 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 266835011250 DNA binding site [nucleotide binding] 266835011251 domain linker motif; other site 266835011252 Ligand-binding domain of DNA-binding regulatory proteins specific to sucrose that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_sucrose_transcription_regulator; cd06288 266835011253 putative dimerization interface [polypeptide binding]; other site 266835011254 putative ligand binding site [chemical binding]; other site 266835011255 Periplasmic sugar-binding domain of Thermotoga maritima glucose-binding protein (tmGBP) and its close homologs; Region: PBP1_tmGBP; cd06314 266835011256 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 266835011257 ligand binding site [chemical binding]; other site 266835011258 dimerization interface [polypeptide binding]; other site 266835011259 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 266835011260 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 266835011261 Walker A/P-loop; other site 266835011262 ATP binding site [chemical binding]; other site 266835011263 Q-loop/lid; other site 266835011264 ABC transporter signature motif; other site 266835011265 Walker B; other site 266835011266 D-loop; other site 266835011267 H-loop/switch region; other site 266835011268 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 266835011269 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 266835011270 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 266835011271 TM-ABC transporter signature motif; other site 266835011272 Predicted membrane protein [Function unknown]; Region: COG4280 266835011273 Uncharacterized component of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: COG3709 266835011274 AAA domain; Region: AAA_33; pfam13671 266835011275 Metal-dependent hydrolase involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: COG3454 266835011276 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 266835011277 PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306 266835011278 active site 266835011279 putative phosphonate metabolism protein; Region: Phn_opern_protn; TIGR03223 266835011280 Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718 266835011281 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 266835011282 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 266835011283 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 266835011284 dimer interface [polypeptide binding]; other site 266835011285 PYR/PP interface [polypeptide binding]; other site 266835011286 TPP binding site [chemical binding]; other site 266835011287 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 266835011288 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 266835011289 TPP-binding site; other site 266835011290 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 266835011291 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 266835011292 substrate binding site [chemical binding]; other site 266835011293 ATP binding site [chemical binding]; other site 266835011294 Uncharacterized protein conserved in bacteria (DUF2090); Region: DUF2090; pfam09863 266835011295 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3892 266835011296 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 266835011297 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 266835011298 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 266835011299 putative active site [active] 266835011300 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 266835011301 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 266835011302 Predicted transcriptional regulator [Transcription]; Region: COG2378 266835011303 HTH domain; Region: HTH_11; pfam08279 266835011304 WYL domain; Region: WYL; pfam13280 266835011305 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 266835011306 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 266835011307 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 266835011308 short chain dehydrogenase; Provisional; Region: PRK06198 266835011309 classical (c) SDRs; Region: SDR_c; cd05233 266835011310 NAD(P) binding site [chemical binding]; other site 266835011311 active site 266835011312 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 266835011313 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 266835011314 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 266835011315 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 266835011316 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 266835011317 Walker A/P-loop; other site 266835011318 ATP binding site [chemical binding]; other site 266835011319 Q-loop/lid; other site 266835011320 ABC transporter signature motif; other site 266835011321 Walker B; other site 266835011322 D-loop; other site 266835011323 H-loop/switch region; other site 266835011324 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 266835011325 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 266835011326 TM-ABC transporter signature motif; other site 266835011327 Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301 266835011328 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 266835011329 putative ligand binding site [chemical binding]; other site 266835011330 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 266835011331 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 266835011332 DNA binding site [nucleotide binding] 266835011333 Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307 266835011334 putative ligand binding site [chemical binding]; other site 266835011335 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 266835011336 This CD includes the putative hydrocarbon oxygenase, MocD, a bacterial rhizopine (3-O-methyl-scyllo-inosamine, 3-O-MSI) oxygenase, and other related proteins. It has been proposed that MocD, MocE (Rieske-like ferredoxin), and MocF (ferredoxin reductase)...; Region: Rhizopine-oxygenase-like; cd03511 266835011337 putative di-iron ligands [ion binding]; other site 266835011338 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 266835011339 [2Fe-2S] cluster binding site [ion binding]; other site 266835011340 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 266835011341 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 266835011342 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 266835011343 Protein of unknown function (DUF1402); Region: DUF1402; pfam07182 266835011344 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 266835011345 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266835011346 Walker A motif; other site 266835011347 ATP binding site [chemical binding]; other site 266835011348 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 266835011349 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 266835011350 hypothetical protein; Provisional; Region: PRK00944 266835011351 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 266835011352 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 266835011353 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 266835011354 Coenzyme A binding pocket [chemical binding]; other site 266835011355 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 266835011356 active site 266835011357 HslU subunit interaction site [polypeptide binding]; other site 266835011358 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 266835011359 putative active site pocket [active] 266835011360 4-fold oligomerization interface [polypeptide binding]; other site 266835011361 metal binding residues [ion binding]; metal-binding site 266835011362 3-fold/trimer interface [polypeptide binding]; other site 266835011363 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 266835011364 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 266835011365 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 266835011366 putative active site [active] 266835011367 oxyanion strand; other site 266835011368 catalytic triad [active] 266835011369 Uncharacterized conserved protein [Function unknown]; Region: COG5470 266835011370 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 266835011371 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 266835011372 catalytic residues [active] 266835011373 Arginase-like amidino hydrolase family; Region: Arginase-like_1; cd09999 266835011374 active site 266835011375 Mn binding site [ion binding]; other site 266835011376 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 266835011377 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 266835011378 substrate binding site [chemical binding]; other site 266835011379 glutamase interaction surface [polypeptide binding]; other site 266835011380 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 266835011381 metal binding site [ion binding]; metal-binding site 266835011382 pantothenate kinase; Provisional; Region: PRK05439 266835011383 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 266835011384 ATP-binding site [chemical binding]; other site 266835011385 CoA-binding site [chemical binding]; other site 266835011386 Mg2+-binding site [ion binding]; other site 266835011387 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 266835011388 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 266835011389 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 266835011390 protein binding site [polypeptide binding]; other site 266835011391 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 266835011392 protein binding site [polypeptide binding]; other site 266835011393 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 266835011394 6-phosphofructokinase; Provisional; Region: PRK14072 266835011395 active site 266835011396 ADP/pyrophosphate binding site [chemical binding]; other site 266835011397 dimerization interface [polypeptide binding]; other site 266835011398 allosteric effector site; other site 266835011399 fructose-1,6-bisphosphate binding site; other site 266835011400 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 266835011401 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 266835011402 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 266835011403 Type V secretory pathway, adhesin AidA [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: AidA; COG3468 266835011404 Autotransporter beta-domain; Region: Autotransporter; smart00869 266835011405 StaR_like; a well-conserved protein found in bacteria, plants, and animals. A family member from Streptomyces toyocaensis, StaR is part of a gene cluster involved in the biosynthesis of glycopeptide antibiotics (GPAs), specifically A47934. It has been...; Region: StaR_like; cd05804 266835011406 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 266835011407 N- and C-terminal domain interface [polypeptide binding]; other site 266835011408 D-xylulose kinase; Region: XylB; TIGR01312 266835011409 active site 266835011410 MgATP binding site [chemical binding]; other site 266835011411 catalytic site [active] 266835011412 metal binding site [ion binding]; metal-binding site 266835011413 xylulose binding site [chemical binding]; other site 266835011414 homodimer interface [polypeptide binding]; other site 266835011415 SnoaL-like domain; Region: SnoaL_2; pfam12680 266835011416 xylose isomerase; Provisional; Region: PRK05474 266835011417 xylose isomerase; Region: xylose_isom_A; TIGR02630 266835011418 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 266835011419 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 266835011420 conserved cys residue [active] 266835011421 Uncharacterized conserved protein [Function unknown]; Region: COG3246 266835011422 Predicted HD phosphohydrolase [General function prediction only]; Region: COG4341 266835011423 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 266835011424 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 266835011425 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 266835011426 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 266835011427 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 266835011428 active site 266835011429 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 266835011430 CoA binding domain; Region: CoA_binding_2; pfam13380 266835011431 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 266835011432 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 266835011433 carnitinyl-CoA dehydratase; Provisional; Region: PRK03580 266835011434 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266835011435 substrate binding site [chemical binding]; other site 266835011436 oxyanion hole (OAH) forming residues; other site 266835011437 trimer interface [polypeptide binding]; other site 266835011438 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 266835011439 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 266835011440 substrate binding pocket [chemical binding]; other site 266835011441 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 266835011442 FAD binding domain; Region: FAD_binding_2; pfam00890 266835011443 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 266835011444 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 266835011445 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 266835011446 Uncharacterized conserved protein [Function unknown]; Region: COG2353 266835011447 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 266835011448 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266835011449 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266835011450 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 266835011451 putative effector binding pocket; other site 266835011452 putative dimerization interface [polypeptide binding]; other site 266835011453 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 266835011454 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 266835011455 active site 266835011456 catalytic tetrad [active] 266835011457 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3575 266835011458 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 266835011459 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 266835011460 putative tRNA-binding site [nucleotide binding]; other site 266835011461 B3/4 domain; Region: B3_4; pfam03483 266835011462 tRNA synthetase B5 domain; Region: B5; smart00874 266835011463 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 266835011464 dimer interface [polypeptide binding]; other site 266835011465 motif 1; other site 266835011466 motif 3; other site 266835011467 motif 2; other site 266835011468 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896 266835011469 Uncharacterized conserved protein [Function unknown]; Region: COG3791 266835011470 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 266835011471 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 266835011472 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 266835011473 dimer interface [polypeptide binding]; other site 266835011474 motif 1; other site 266835011475 active site 266835011476 motif 2; other site 266835011477 motif 3; other site 266835011478 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 266835011479 23S rRNA binding site [nucleotide binding]; other site 266835011480 L21 binding site [polypeptide binding]; other site 266835011481 L13 binding site [polypeptide binding]; other site 266835011482 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 266835011483 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 266835011484 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 266835011485 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 266835011486 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 266835011487 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 266835011488 Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135 266835011489 benzoate transporter; Region: benE; TIGR00843 266835011490 Protein of unknown function (DUF2852); Region: DUF2852; pfam11014 266835011491 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 266835011492 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 266835011493 active site 266835011494 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 266835011495 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 266835011496 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266835011497 catalytic residue [active] 266835011498 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 266835011499 substrate binding site [chemical binding]; other site 266835011500 active site 266835011501 catalytic residues [active] 266835011502 heterodimer interface [polypeptide binding]; other site 266835011503 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 266835011504 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 266835011505 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 266835011506 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266835011507 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 266835011508 active site 266835011509 metal binding site [ion binding]; metal-binding site 266835011510 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 266835011511 oligomeric interface; other site 266835011512 putative active site [active] 266835011513 homodimer interface [polypeptide binding]; other site 266835011514 Cupin domain; Region: Cupin_2; cl17218 266835011515 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 266835011516 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 266835011517 catalytic residues [active] 266835011518 double-strand break repair helicase AddA, alphaproteobacterial type; Region: addA_alphas; TIGR02784 266835011519 Part of AAA domain; Region: AAA_19; pfam13245 266835011520 Family description; Region: UvrD_C_2; pfam13538 266835011521 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 266835011522 double-strand break repair protein AddB, alphaproteobacterial type; Region: addB_alphas; TIGR02786 266835011523 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 266835011524 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 266835011525 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 266835011526 Substrate binding site; other site 266835011527 metal-binding site 266835011528 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 266835011529 Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178 266835011530 Phosphotransferase enzyme family; Region: APH; pfam01636 266835011531 PAS fold; Region: PAS_7; pfam12860 266835011532 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 266835011533 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266835011534 dimer interface [polypeptide binding]; other site 266835011535 phosphorylation site [posttranslational modification] 266835011536 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266835011537 ATP binding site [chemical binding]; other site 266835011538 Mg2+ binding site [ion binding]; other site 266835011539 G-X-G motif; other site 266835011540 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 266835011541 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 266835011542 homotetramer interface [polypeptide binding]; other site 266835011543 ligand binding site [chemical binding]; other site 266835011544 catalytic site [active] 266835011545 NAD binding site [chemical binding]; other site 266835011546 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 266835011547 dimerization domain swap beta strand [polypeptide binding]; other site 266835011548 regulatory protein interface [polypeptide binding]; other site 266835011549 active site 266835011550 regulatory phosphorylation site [posttranslational modification]; other site 266835011551 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 266835011552 active pocket/dimerization site; other site 266835011553 active site 266835011554 phosphorylation site [posttranslational modification] 266835011555 Serine kinase of the HPr protein, regulates carbohydrate metabolism [Signal transduction mechanisms]; Region: HprK; COG1493 266835011556 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270 266835011557 active site 266835011558 metal-binding site [ion binding] 266835011559 nucleotide-binding site [chemical binding]; other site 266835011560 Sensor N-terminal transmembrane domain; Region: Sensor_TM1; pfam13755 266835011561 Stimulus-sensing domain; Region: Stimulus_sens_1; pfam13756 266835011562 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 266835011563 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266835011564 dimer interface [polypeptide binding]; other site 266835011565 phosphorylation site [posttranslational modification] 266835011566 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266835011567 ATP binding site [chemical binding]; other site 266835011568 Mg2+ binding site [ion binding]; other site 266835011569 G-X-G motif; other site 266835011570 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 266835011571 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266835011572 active site 266835011573 phosphorylation site [posttranslational modification] 266835011574 intermolecular recognition site; other site 266835011575 dimerization interface [polypeptide binding]; other site 266835011576 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266835011577 DNA binding site [nucleotide binding] 266835011578 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 266835011579 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 266835011580 active site 266835011581 substrate-binding site [chemical binding]; other site 266835011582 metal-binding site [ion binding] 266835011583 ATP binding site [chemical binding]; other site 266835011584 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 266835011585 hypothetical protein; Provisional; Region: PRK09256 266835011586 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 266835011587 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 266835011588 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 266835011589 FAD binding pocket [chemical binding]; other site 266835011590 FAD binding motif [chemical binding]; other site 266835011591 phosphate binding motif [ion binding]; other site 266835011592 beta-alpha-beta structure motif; other site 266835011593 NAD binding pocket [chemical binding]; other site 266835011594 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 266835011595 catalytic loop [active] 266835011596 iron binding site [ion binding]; other site 266835011597 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 266835011598 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 266835011599 [2Fe-2S] cluster binding site [ion binding]; other site 266835011600 C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884 266835011601 putative alpha subunit interface [polypeptide binding]; other site 266835011602 putative active site [active] 266835011603 putative substrate binding site [chemical binding]; other site 266835011604 Fe binding site [ion binding]; other site 266835011605 Protein of unknown function (DUF680); Region: DUF680; pfam05079 266835011606 Protein of unknown function (DUF680); Region: DUF680; pfam05079 266835011607 Protein of unknown function (DUF680); Region: DUF680; pfam05079 266835011608 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 266835011609 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 266835011610 Walker A/P-loop; other site 266835011611 ATP binding site [chemical binding]; other site 266835011612 Q-loop/lid; other site 266835011613 ABC transporter signature motif; other site 266835011614 Walker B; other site 266835011615 D-loop; other site 266835011616 H-loop/switch region; other site 266835011617 TOBE domain; Region: TOBE; pfam03459 266835011618 TOBE domain; Region: TOBE_2; pfam08402 266835011619 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase) and related proteins; Region: AmyAc_OligoGlu; cd11330 266835011620 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 266835011621 active site 266835011622 catalytic site [active] 266835011623 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 266835011624 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835011625 dimer interface [polypeptide binding]; other site 266835011626 conserved gate region; other site 266835011627 putative PBP binding loops; other site 266835011628 ABC-ATPase subunit interface; other site 266835011629 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835011630 dimer interface [polypeptide binding]; other site 266835011631 conserved gate region; other site 266835011632 putative PBP binding loops; other site 266835011633 ABC-ATPase subunit interface; other site 266835011634 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 266835011635 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 266835011636 Transcriptional regulators [Transcription]; Region: PurR; COG1609 266835011637 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 266835011638 DNA binding site [nucleotide binding] 266835011639 domain linker motif; other site 266835011640 Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271 266835011641 ligand binding site [chemical binding]; other site 266835011642 Peptidase S8 family domain, uncharacterized subfamily 4; Region: Peptidases_S8_4; cd05561 266835011643 active site 266835011644 catalytic triad [active] 266835011645 RNA polymerase sigma factor; Provisional; Region: PRK12515 266835011646 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 266835011647 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 266835011648 DNA binding residues [nucleotide binding] 266835011649 Uncharacterized proteins of the AP superfamily [General function prediction only]; Region: COG1524 266835011650 Uncharacterized conserved protein [Function unknown]; Region: COG3379 266835011651 phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335 266835011652 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 266835011653 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 266835011654 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 266835011655 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 266835011656 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266835011657 Walker A/P-loop; other site 266835011658 ATP binding site [chemical binding]; other site 266835011659 Q-loop/lid; other site 266835011660 ABC transporter signature motif; other site 266835011661 Walker B; other site 266835011662 D-loop; other site 266835011663 H-loop/switch region; other site 266835011664 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266835011665 Walker A/P-loop; other site 266835011666 ATP binding site [chemical binding]; other site 266835011667 Q-loop/lid; other site 266835011668 ABC transporter signature motif; other site 266835011669 Walker B; other site 266835011670 D-loop; other site 266835011671 H-loop/switch region; other site 266835011672 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 266835011673 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 266835011674 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 266835011675 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835011676 dimer interface [polypeptide binding]; other site 266835011677 conserved gate region; other site 266835011678 ABC-ATPase subunit interface; other site 266835011679 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 266835011680 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835011681 dimer interface [polypeptide binding]; other site 266835011682 conserved gate region; other site 266835011683 ABC-ATPase subunit interface; other site 266835011684 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 266835011685 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 266835011686 Predicted acyl esterases [General function prediction only]; Region: COG2936 266835011687 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 266835011688 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 266835011689 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 266835011690 nucleoside/Zn binding site; other site 266835011691 dimer interface [polypeptide binding]; other site 266835011692 catalytic motif [active] 266835011693 Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194 266835011694 ureidoglycolate hydrolase; Provisional; Region: PRK03606 266835011695 hypothetical protein; Provisional; Region: PRK11171 266835011696 Protein of unknown function (DUF861); Region: Cupin_3; pfam05899 266835011697 Cupin domain; Region: Cupin_2; cl17218 266835011698 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 266835011699 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 266835011700 active site 266835011701 catalytic site [active] 266835011702 tetramer interface [polypeptide binding]; other site 266835011703 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3195 266835011704 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 266835011705 active site 266835011706 homotetramer interface [polypeptide binding]; other site 266835011707 Xanthine dehydrogenase, iron-sulfur cluster and FAD-binding subunit A [Nucleotide transport and metabolism]; Region: XdhA; COG4630 266835011708 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 266835011709 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 266835011710 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 266835011711 Xanthine dehydrogenase, molybdopterin-binding subunit B [Nucleotide transport and metabolism]; Region: XdhB; COG4631 266835011712 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 266835011713 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 266835011714 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 266835011715 xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964 266835011716 XdhC Rossmann domain; Region: XdhC_C; pfam13478 266835011717 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 266835011718 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 266835011719 active site 266835011720 non-prolyl cis peptide bond; other site 266835011721 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 266835011722 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 266835011723 active site 266835011724 non-prolyl cis peptide bond; other site 266835011725 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266835011726 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266835011727 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 266835011728 putative effector binding pocket; other site 266835011729 dimerization interface [polypeptide binding]; other site 266835011730 Predicted membrane protein [Function unknown]; Region: COG3748 266835011731 Protein of unknown function (DUF989); Region: DUF989; pfam06181 266835011732 Cytochrome c; Region: Cytochrom_C; pfam00034 266835011733 guanine deaminase; Provisional; Region: PRK09228 266835011734 Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303 266835011735 active site 266835011736 Uncharacterized conserved protein [Function unknown]; Region: COG4702 266835011737 Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379 266835011738 Domain of unknown function (DUF4147); Region: DUF4147; pfam13660 266835011739 MOFRL family; Region: MOFRL; pfam05161 266835011740 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 266835011741 Fe-S cluster binding site [ion binding]; other site 266835011742 active site 266835011743 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 266835011744 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 266835011745 aminotransferase; Validated; Region: PRK07046 266835011746 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 266835011747 inhibitor-cofactor binding pocket; inhibition site 266835011748 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266835011749 catalytic residue [active] 266835011750 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 266835011751 MarR family; Region: MarR; pfam01047 266835011752 FOG: WD40 repeat [General function prediction only]; Region: COG2319 266835011753 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 266835011754 structural tetrad; other site 266835011755 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 266835011756 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 266835011757 P-loop, Walker A motif; other site 266835011758 Base recognition motif; other site 266835011759 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 266835011760 MarR family; Region: MarR_2; pfam12802 266835011761 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 266835011762 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 266835011763 Helix-turn-helix domain; Region: HTH_18; pfam12833 266835011764 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266835011765 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4954 266835011766 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 266835011767 Transcriptional regulators [Transcription]; Region: PurR; COG1609 266835011768 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 266835011769 DNA binding site [nucleotide binding] 266835011770 domain linker motif; other site 266835011771 Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289 266835011772 putative dimerization interface [polypeptide binding]; other site 266835011773 putative ligand binding site [chemical binding]; other site 266835011774 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 266835011775 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 266835011776 putative ligand binding site [chemical binding]; other site 266835011777 NAD binding site [chemical binding]; other site 266835011778 catalytic site [active] 266835011779 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 266835011780 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 266835011781 catalytic triad [active] 266835011782 TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663 266835011783 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 266835011784 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266835011785 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 266835011786 active site 266835011787 metal binding site [ion binding]; metal-binding site 266835011788 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 266835011789 L-threonine dehydrogenase; Region: threonine_DH_like; cd08234 266835011790 catalytic Zn binding site [ion binding]; other site 266835011791 putative NAD(P) binding site [chemical binding]; other site 266835011792 TRAP-type mannitol/chloroaromatic compound transport system, large permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT3; COG4664 266835011793 TRAP-type mannitol/chloroaromatic compound transport system, large permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT3; COG4664 266835011794 TRAP-type mannitol/chloroaromatic compound transport system, small permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT2; COG4665 266835011795 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 266835011796 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 266835011797 TM-ABC transporter signature motif; other site 266835011798 Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding [General function prediction only]; Region: COG5516 266835011799 CGNR zinc finger; Region: zf-CGNR; pfam11706 266835011800 indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193 266835011801 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 266835011802 dimer interface [polypeptide binding]; other site 266835011803 PYR/PP interface [polypeptide binding]; other site 266835011804 TPP binding site [chemical binding]; other site 266835011805 substrate binding site [chemical binding]; other site 266835011806 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 266835011807 TPP-binding site; other site 266835011808 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 266835011809 PAS fold; Region: PAS_7; pfam12860 266835011810 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 266835011811 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266835011812 metal binding site [ion binding]; metal-binding site 266835011813 active site 266835011814 I-site; other site 266835011815 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 266835011816 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 266835011817 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 266835011818 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 266835011819 ligand binding site [chemical binding]; other site 266835011820 homodimer interface [polypeptide binding]; other site 266835011821 NAD(P) binding site [chemical binding]; other site 266835011822 trimer interface B [polypeptide binding]; other site 266835011823 trimer interface A [polypeptide binding]; other site 266835011824 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 266835011825 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 266835011826 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 266835011827 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 266835011828 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266835011829 Mg2+ binding site [ion binding]; other site 266835011830 G-X-G motif; other site 266835011831 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 266835011832 anchoring element; other site 266835011833 dimer interface [polypeptide binding]; other site 266835011834 ATP binding site [chemical binding]; other site 266835011835 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 266835011836 active site 266835011837 putative metal-binding site [ion binding]; other site 266835011838 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 266835011839 Uncharacterized protein containing caspase domain [General function prediction only]; Region: COG4249 266835011840 Caspase domain; Region: Peptidase_C14; pfam00656 266835011841 active site 266835011842 substrate pocket [chemical binding]; other site 266835011843 proteolytic cleavage site; other site 266835011844 dimer interface [polypeptide binding]; other site 266835011845 Tetratricopeptide repeat; Region: TPR_12; pfam13424 266835011846 Tetratricopeptide repeat; Region: TPR_12; pfam13424 266835011847 Tetratricopeptide repeat; Region: TPR_12; pfam13424 266835011848 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 266835011849 TPR motif; other site 266835011850 binding surface 266835011851 Tetratricopeptide repeat; Region: TPR_12; pfam13424 266835011852 Predicted flavoprotein [General function prediction only]; Region: COG0431 266835011853 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 266835011854 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 266835011855 Cytochrome P450; Region: p450; cl12078 266835011856 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271 266835011857 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 266835011858 putative NAD(P) binding site [chemical binding]; other site 266835011859 active site 266835011860 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 266835011861 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 266835011862 conserved cys residue [active] 266835011863 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266835011864 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 266835011865 conserved cys residue [active] 266835011866 Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055 266835011867 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 266835011868 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835011869 dimer interface [polypeptide binding]; other site 266835011870 conserved gate region; other site 266835011871 putative PBP binding loops; other site 266835011872 ABC-ATPase subunit interface; other site 266835011873 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 266835011874 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835011875 dimer interface [polypeptide binding]; other site 266835011876 conserved gate region; other site 266835011877 putative PBP binding loops; other site 266835011878 ABC-ATPase subunit interface; other site 266835011879 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 266835011880 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 266835011881 substrate binding pocket [chemical binding]; other site 266835011882 membrane-bound complex binding site; other site 266835011883 hinge residues; other site 266835011884 ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598 266835011885 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 266835011886 Walker A/P-loop; other site 266835011887 ATP binding site [chemical binding]; other site 266835011888 Q-loop/lid; other site 266835011889 ABC transporter signature motif; other site 266835011890 Walker B; other site 266835011891 D-loop; other site 266835011892 H-loop/switch region; other site 266835011893 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 266835011894 Amidinotransferase; Region: Amidinotransf; pfam02274 266835011895 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266835011896 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 266835011897 hypothetical protein; Provisional; Region: PRK07524 266835011898 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 266835011899 PYR/PP interface [polypeptide binding]; other site 266835011900 dimer interface [polypeptide binding]; other site 266835011901 TPP binding site [chemical binding]; other site 266835011902 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 266835011903 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 266835011904 TPP-binding site [chemical binding]; other site 266835011905 short chain dehydrogenase; Provisional; Region: PRK12828 266835011906 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835011907 NAD(P) binding site [chemical binding]; other site 266835011908 active site 266835011909 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 266835011910 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 266835011911 RNA binding site [nucleotide binding]; other site 266835011912 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 266835011913 RNA binding site [nucleotide binding]; other site 266835011914 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 266835011915 RNA binding site [nucleotide binding]; other site 266835011916 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 266835011917 RNA binding site [nucleotide binding]; other site 266835011918 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 266835011919 RNA binding site [nucleotide binding]; other site 266835011920 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 266835011921 RNA binding site [nucleotide binding]; other site 266835011922 cytidylate kinase; Provisional; Region: cmk; PRK00023 266835011923 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 266835011924 CMP-binding site; other site 266835011925 The sites determining sugar specificity; other site 266835011926 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 266835011927 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 266835011928 hinge; other site 266835011929 active site 266835011930 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4530 266835011931 Protein of unknown function (FYDLN_acid); Region: FYDLN_acid; pfam09538 266835011932 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 266835011933 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 266835011934 active site 266835011935 dimer interface [polypeptide binding]; other site 266835011936 non-prolyl cis peptide bond; other site 266835011937 insertion regions; other site 266835011938 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 266835011939 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 266835011940 dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021 266835011941 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 266835011942 active site 266835011943 dimer interface [polypeptide binding]; other site 266835011944 non-prolyl cis peptide bond; other site 266835011945 insertion regions; other site 266835011946 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 266835011947 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 266835011948 Walker A/P-loop; other site 266835011949 ATP binding site [chemical binding]; other site 266835011950 Q-loop/lid; other site 266835011951 ABC transporter signature motif; other site 266835011952 Walker B; other site 266835011953 D-loop; other site 266835011954 H-loop/switch region; other site 266835011955 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 266835011956 TM-ABC transporter signature motif; other site 266835011957 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 266835011958 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 266835011959 TM-ABC transporter signature motif; other site 266835011960 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_1; cd06334 266835011961 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 266835011962 putative ligand binding site [chemical binding]; other site 266835011963 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 266835011964 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 266835011965 Walker A/P-loop; other site 266835011966 ATP binding site [chemical binding]; other site 266835011967 Q-loop/lid; other site 266835011968 ABC transporter signature motif; other site 266835011969 Walker B; other site 266835011970 D-loop; other site 266835011971 H-loop/switch region; other site 266835011972 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 266835011973 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 266835011974 Flavin binding site [chemical binding]; other site 266835011975 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 266835011976 FMN reductase, MsuE subfamily; Region: FMN_reduc_MsuE; TIGR03566 266835011977 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 266835011978 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 266835011979 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 266835011980 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 266835011981 Sarcosine oxidase delta subunit [Amino acid transport and metabolism]; Region: SoxD; COG4311 266835011982 sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373 266835011983 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266835011984 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266835011985 Bacillus subtilis NADP+-dependent alpha-ketoglutaric semialdehyde dehydrogenase ycbD-like; Region: ALDH_KGSADH-YcbD; cd07097 266835011986 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 266835011987 NAD(P) binding site [chemical binding]; other site 266835011988 catalytic residues [active] 266835011989 Uncharacterized conserved protein [Function unknown]; Region: COG3506 266835011990 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 266835011991 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 266835011992 mercuric reductase; Validated; Region: PRK06370 266835011993 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 266835011994 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 266835011995 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 266835011996 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5368 266835011997 Putative glucoamylase; Region: Glycoamylase; pfam10091 266835011998 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 266835011999 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835012000 NAD(P) binding site [chemical binding]; other site 266835012001 active site 266835012002 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 266835012003 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266835012004 DNA binding residues [nucleotide binding] 266835012005 dimerization interface [polypeptide binding]; other site 266835012006 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 266835012007 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 266835012008 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 266835012009 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 266835012010 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 266835012011 Acetone carboxylase, gamma subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcxC; COG4647 266835012012 Acetone carboxylase gamma subunit; Region: Acetone_carb_G; pfam08882 266835012013 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 266835012014 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835012015 NAD(P) binding site [chemical binding]; other site 266835012016 active site 266835012017 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 266835012018 O-Antigen ligase; Region: Wzy_C; pfam04932 266835012019 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 266835012020 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 266835012021 SLBB domain; Region: SLBB; pfam10531 266835012022 Bacterial sugar transferase; Region: Bac_transf; pfam02397 266835012023 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 266835012024 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 266835012025 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266835012026 Walker A/P-loop; other site 266835012027 ATP binding site [chemical binding]; other site 266835012028 Q-loop/lid; other site 266835012029 ABC transporter signature motif; other site 266835012030 Walker B; other site 266835012031 D-loop; other site 266835012032 H-loop/switch region; other site 266835012033 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270 266835012034 active site 266835012035 nucleotide-binding site [chemical binding]; other site 266835012036 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 266835012037 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 266835012038 active site 266835012039 dimer interface [polypeptide binding]; other site 266835012040 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 266835012041 Ligand Binding Site [chemical binding]; other site 266835012042 Molecular Tunnel; other site 266835012043 Transglutaminase-like superfamily; Region: Transglut_core3; pfam13471 266835012044 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 266835012045 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 266835012046 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 266835012047 Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273 266835012048 lichenase, member of glycosyl hydrolase family 16; Region: GH16_lichenase; cd02175 266835012049 active site 266835012050 active site 266835012051 catalytic residues [active] 266835012052 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 266835012053 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 266835012054 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 266835012055 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 266835012056 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 266835012057 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 266835012058 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 266835012059 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 266835012060 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 266835012061 active site 266835012062 Uncharacterized conserved protein [Function unknown]; Region: COG5663 266835012063 colanic acid exporter; Provisional; Region: PRK10459 266835012064 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 266835012065 ExoA is involved in the biosynthesis of succinoglycan; Region: Succinoglycan_BP_ExoA; cd02525 266835012066 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 266835012067 Ligand binding site; other site 266835012068 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 266835012069 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 266835012070 active site 266835012071 putative glycosyl transferase; Provisional; Region: PRK10073 266835012072 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 266835012073 active site 266835012074 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 266835012075 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 266835012076 active site 266835012077 tetramer interface; other site 266835012078 exopolysaccharide transport protein family; Region: eps_transp_fam; TIGR01005 266835012079 Chain length determinant protein; Region: Wzz; pfam02706 266835012080 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266835012081 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266835012082 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266835012083 dimerization interface [polypeptide binding]; other site 266835012084 short chain dehydrogenase; Provisional; Region: PRK06500 266835012085 classical (c) SDRs; Region: SDR_c; cd05233 266835012086 NAD(P) binding site [chemical binding]; other site 266835012087 active site 266835012088 short chain dehydrogenase; Provisional; Region: PRK06500 266835012089 classical (c) SDRs; Region: SDR_c; cd05233 266835012090 NAD(P) binding site [chemical binding]; other site 266835012091 active site 266835012092 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 266835012093 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 266835012094 Domain of unknown function (DUF4380); Region: DUF4380; pfam14315 266835012095 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 266835012096 Predicted methyltransferase [General function prediction only]; Region: COG4798 266835012097 S-adenosylmethionine binding site [chemical binding]; other site 266835012098 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 266835012099 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 266835012100 Propionyl-CoA synthetase (PrpE); Region: PrpE; cd05967 266835012101 acyl-activating enzyme (AAE) consensus motif; other site 266835012102 putative AMP binding site [chemical binding]; other site 266835012103 putative active site [active] 266835012104 putative CoA binding site [chemical binding]; other site 266835012105 Predicted secreted protein [Function unknown]; Region: COG5497 266835012106 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 266835012107 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 266835012108 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 266835012109 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 266835012110 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 266835012111 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 266835012112 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 266835012113 dimerization domain swap beta strand [polypeptide binding]; other site 266835012114 regulatory protein interface [polypeptide binding]; other site 266835012115 active site 266835012116 regulatory phosphorylation site [posttranslational modification]; other site 266835012117 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 266835012118 active pocket/dimerization site; other site 266835012119 active site 266835012120 phosphorylation site [posttranslational modification] 266835012121 DAK2 domain; Region: Dak2; cl03685 266835012122 dihydroxyacetone kinase-like protein; Provisional; Region: PTZ00375 266835012123 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 266835012124 DAK2 domain; Region: Dak2; pfam02734 266835012125 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 266835012126 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 266835012127 Walker A/P-loop; other site 266835012128 ATP binding site [chemical binding]; other site 266835012129 Q-loop/lid; other site 266835012130 ABC transporter signature motif; other site 266835012131 Walker B; other site 266835012132 D-loop; other site 266835012133 H-loop/switch region; other site 266835012134 TOBE domain; Region: TOBE_2; pfam08402 266835012135 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 266835012136 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266835012137 Walker A/P-loop; other site 266835012138 ATP binding site [chemical binding]; other site 266835012139 Q-loop/lid; other site 266835012140 ABC transporter signature motif; other site 266835012141 Walker B; other site 266835012142 D-loop; other site 266835012143 H-loop/switch region; other site 266835012144 TOBE domain; Region: TOBE_2; pfam08402 266835012145 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 266835012146 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835012147 dimer interface [polypeptide binding]; other site 266835012148 conserved gate region; other site 266835012149 putative PBP binding loops; other site 266835012150 ABC-ATPase subunit interface; other site 266835012151 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 266835012152 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835012153 dimer interface [polypeptide binding]; other site 266835012154 conserved gate region; other site 266835012155 putative PBP binding loops; other site 266835012156 ABC-ATPase subunit interface; other site 266835012157 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 266835012158 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 266835012159 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 266835012160 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 266835012161 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 266835012162 EamA-like transporter family; Region: EamA; pfam00892 266835012163 HrpA-like helicases [DNA replication, recombination, and repair]; Region: HrpA; COG1643 266835012164 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 266835012165 ATP binding site [chemical binding]; other site 266835012166 putative Mg++ binding site [ion binding]; other site 266835012167 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 266835012168 nucleotide binding region [chemical binding]; other site 266835012169 ATP-binding site [chemical binding]; other site 266835012170 Helicase associated domain (HA2); Region: HA2; pfam04408 266835012171 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 266835012172 Plant transposase (Ptta/En/Spm family); Region: Transposase_24; pfam03004 266835012173 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 266835012174 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266835012175 ATP binding site [chemical binding]; other site 266835012176 Mg2+ binding site [ion binding]; other site 266835012177 G-X-G motif; other site 266835012178 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567 266835012179 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266835012180 active site 266835012181 phosphorylation site [posttranslational modification] 266835012182 intermolecular recognition site; other site 266835012183 dimerization interface [polypeptide binding]; other site 266835012184 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 266835012185 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09560 266835012186 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5321 266835012187 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 266835012188 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 266835012189 DNA binding residues [nucleotide binding] 266835012190 dimer interface [polypeptide binding]; other site 266835012191 copper binding site [ion binding]; other site 266835012192 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 266835012193 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 266835012194 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; pfam08712 266835012195 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 266835012196 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 266835012197 Ligand Binding Site [chemical binding]; other site 266835012198 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 266835012199 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 266835012200 active site 266835012201 HIGH motif; other site 266835012202 dimer interface [polypeptide binding]; other site 266835012203 KMSKS motif; other site 266835012204 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 266835012205 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 266835012206 active site 266835012207 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 266835012208 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 266835012209 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 266835012210 PII uridylyl-transferase; Provisional; Region: PRK05092 266835012211 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 266835012212 metal binding triad; other site 266835012213 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 266835012214 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 266835012215 Zn2+ binding site [ion binding]; other site 266835012216 Mg2+ binding site [ion binding]; other site 266835012217 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 266835012218 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 266835012219 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532 266835012220 YHS domain; Region: YHS; pfam04945 266835012221 YHS domain; Region: YHS; pfam04945 266835012222 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 266835012223 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 266835012224 Soluble P-type ATPase [General function prediction only]; Region: COG4087 266835012225 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3544 266835012226 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 266835012227 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 266835012228 active site 266835012229 catalytic tetrad [active] 266835012230 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 266835012231 MutS domain I; Region: MutS_I; pfam01624 266835012232 MutS domain II; Region: MutS_II; pfam05188 266835012233 MutS domain III; Region: MutS_III; pfam05192 266835012234 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 266835012235 Walker A/P-loop; other site 266835012236 ATP binding site [chemical binding]; other site 266835012237 Q-loop/lid; other site 266835012238 ABC transporter signature motif; other site 266835012239 Walker B; other site 266835012240 D-loop; other site 266835012241 H-loop/switch region; other site 266835012242 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 266835012243 Malic enzyme, N-terminal domain; Region: malic; pfam00390 266835012244 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 266835012245 putative NAD(P) binding site [chemical binding]; other site 266835012246 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 266835012247 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266835012248 PAS fold; Region: PAS_3; pfam08447 266835012249 putative active site [active] 266835012250 heme pocket [chemical binding]; other site 266835012251 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 266835012252 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266835012253 metal binding site [ion binding]; metal-binding site 266835012254 active site 266835012255 I-site; other site 266835012256 Protein of unknown function (DUF2384); Region: DUF2384; cl17718 266835012257 Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168 266835012258 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 266835012259 substrate binding site [chemical binding]; other site 266835012260 ATP binding site [chemical binding]; other site 266835012261 EamA-like transporter family; Region: EamA; pfam00892 266835012262 EamA-like transporter family; Region: EamA; pfam00892 266835012263 CysZ-like protein; Reviewed; Region: PRK12768 266835012264 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 266835012265 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 266835012266 tetramer interface [polypeptide binding]; other site 266835012267 active site 266835012268 Mg2+/Mn2+ binding site [ion binding]; other site 266835012269 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 266835012270 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 266835012271 motif II; other site 266835012272 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 266835012273 trimer interface [polypeptide binding]; other site 266835012274 active site 266835012275 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 266835012276 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266835012277 putative DNA binding site [nucleotide binding]; other site 266835012278 putative Zn2+ binding site [ion binding]; other site 266835012279 AsnC family; Region: AsnC_trans_reg; pfam01037 266835012280 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 266835012281 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 266835012282 putative active site [active] 266835012283 putative dimer interface [polypeptide binding]; other site 266835012284 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 266835012285 Amidase; Region: Amidase; pfam01425 266835012286 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 266835012287 hydroxyglutarate oxidase; Provisional; Region: PRK11728 266835012288 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266835012289 haloalkane dehalogenase; Provisional; Region: PRK03592 266835012290 Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108 266835012291 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 266835012292 G1 box; other site 266835012293 putative GEF interaction site [polypeptide binding]; other site 266835012294 GTP/Mg2+ binding site [chemical binding]; other site 266835012295 Switch I region; other site 266835012296 G2 box; other site 266835012297 G3 box; other site 266835012298 Switch II region; other site 266835012299 G4 box; other site 266835012300 G5 box; other site 266835012301 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 266835012302 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 266835012303 dimer interface [polypeptide binding]; other site 266835012304 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_9; cd07826 266835012305 putative hydrophobic ligand binding site [chemical binding]; other site 266835012306 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266835012307 dimerization interface [polypeptide binding]; other site 266835012308 putative DNA binding site [nucleotide binding]; other site 266835012309 putative Zn2+ binding site [ion binding]; other site 266835012310 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 266835012311 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 266835012312 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 266835012313 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 266835012314 Walker A/P-loop; other site 266835012315 ATP binding site [chemical binding]; other site 266835012316 Q-loop/lid; other site 266835012317 ABC transporter signature motif; other site 266835012318 Walker B; other site 266835012319 D-loop; other site 266835012320 H-loop/switch region; other site 266835012321 cytosine deaminase; Validated; Region: PRK07572 266835012322 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 266835012323 active site 266835012324 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 266835012325 EamA-like transporter family; Region: EamA; pfam00892 266835012326 Predicted membrane protein [Function unknown]; Region: COG3152 266835012327 Choline Kinase (ChoK). The ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: ChoK; cd05151 266835012328 active site 266835012329 ATP binding site [chemical binding]; other site 266835012330 Phosphotransferase enzyme family; Region: APH; pfam01636 266835012331 substrate binding site [chemical binding]; other site 266835012332 dimer interface [polypeptide binding]; other site 266835012333 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266835012334 S-adenosylmethionine binding site [chemical binding]; other site 266835012335 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 266835012336 hydroxyglutarate oxidase; Provisional; Region: PRK11728 266835012337 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 266835012338 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 266835012339 Choline Kinase (ChoK). The ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: ChoK; cd05151 266835012340 Phosphotransferase enzyme family; Region: APH; pfam01636 266835012341 active site 266835012342 ATP binding site [chemical binding]; other site 266835012343 substrate binding site [chemical binding]; other site 266835012344 dimer interface [polypeptide binding]; other site 266835012345 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 266835012346 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 266835012347 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 266835012348 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 266835012349 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 266835012350 dimer interface [polypeptide binding]; other site 266835012351 phosphorylation site [posttranslational modification] 266835012352 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266835012353 ATP binding site [chemical binding]; other site 266835012354 Mg2+ binding site [ion binding]; other site 266835012355 G-X-G motif; other site 266835012356 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 266835012357 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266835012358 active site 266835012359 phosphorylation site [posttranslational modification] 266835012360 intermolecular recognition site; other site 266835012361 dimerization interface [polypeptide binding]; other site 266835012362 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266835012363 DNA binding site [nucleotide binding] 266835012364 Phospholipid N-methyltransferase [Lipid metabolism]; Region: COG3963 266835012365 S-adenosylmethionine binding site [chemical binding]; other site 266835012366 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 266835012367 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 266835012368 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266835012369 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266835012370 The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412 266835012371 putative substrate binding pocket [chemical binding]; other site 266835012372 dimerization interface [polypeptide binding]; other site 266835012373 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg6; cd04781 266835012374 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 266835012375 DNA binding residues [nucleotide binding] 266835012376 putative dimer interface [polypeptide binding]; other site 266835012377 putative metal binding residues [ion binding]; other site 266835012378 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 266835012379 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266835012380 S-adenosylmethionine binding site [chemical binding]; other site 266835012381 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 266835012382 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 266835012383 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 266835012384 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266835012385 Walker A/P-loop; other site 266835012386 ATP binding site [chemical binding]; other site 266835012387 Q-loop/lid; other site 266835012388 ABC transporter signature motif; other site 266835012389 Walker B; other site 266835012390 D-loop; other site 266835012391 H-loop/switch region; other site 266835012392 TOBE domain; Region: TOBE_2; pfam08402 266835012393 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835012394 putative PBP binding loops; other site 266835012395 dimer interface [polypeptide binding]; other site 266835012396 ABC-ATPase subunit interface; other site 266835012397 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 266835012398 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835012399 dimer interface [polypeptide binding]; other site 266835012400 conserved gate region; other site 266835012401 putative PBP binding loops; other site 266835012402 ABC-ATPase subunit interface; other site 266835012403 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 266835012404 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 266835012405 tetrameric interface [polypeptide binding]; other site 266835012406 NAD binding site [chemical binding]; other site 266835012407 catalytic residues [active] 266835012408 substrate binding site [chemical binding]; other site 266835012409 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 266835012410 Transposase; Region: DEDD_Tnp_IS110; pfam01548 266835012411 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 266835012412 SnoaL-like domain; Region: SnoaL_2; pfam12680 266835012413 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 266835012414 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 266835012415 TAP-like protein; Region: Abhydrolase_4; pfam08386 266835012416 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 266835012417 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 266835012418 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 266835012419 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266835012420 DNA binding residues [nucleotide binding] 266835012421 dimerization interface [polypeptide binding]; other site 266835012422 NADH-dependant formate dehydrogenase delta subunit FdsD; Region: FdsD; pfam11390 266835012423 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 266835012424 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 266835012425 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 266835012426 catalytic loop [active] 266835012427 iron binding site [ion binding]; other site 266835012428 4Fe-4S binding domain; Region: Fer4; pfam00037 266835012429 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 266835012430 [4Fe-4S] binding site [ion binding]; other site 266835012431 molybdopterin cofactor binding site; other site 266835012432 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 266835012433 molybdopterin cofactor binding site; other site 266835012434 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NAD-dependent formate dehydrogenase (FDH) beta subunit; composed of proteins similar to the beta subunit of NAD-linked FDH of Ralstonia eutropha, a soluble enzyme that catalyzes the irreversible oxidation of...; Region: TRX_Fd_FDH_beta; cd03063 266835012435 putative dimer interface [polypeptide binding]; other site 266835012436 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 266835012437 SLBB domain; Region: SLBB; pfam10531 266835012438 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 266835012439 formate dehydrogenase subunit gamma; Validated; Region: PRK05988 266835012440 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily, NAD-dependent formate dehydrogenase (FDH) gamma subunit; composed of proteins similar to the gamma subunit of NAD-linked FDH of Ralstonia eutropha, a...; Region: TRX_Fd_NuoE_FDH_gamma; cd03081 266835012441 putative dimer interface [polypeptide binding]; other site 266835012442 [2Fe-2S] cluster binding site [ion binding]; other site 266835012443 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266835012444 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266835012445 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 266835012446 dimerization interface [polypeptide binding]; other site 266835012447 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 266835012448 GAF domain; Region: GAF; pfam01590 266835012449 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 266835012450 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266835012451 metal binding site [ion binding]; metal-binding site 266835012452 active site 266835012453 I-site; other site 266835012454 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 266835012455 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266835012456 active site 266835012457 Domain of unknown function DUF59; Region: DUF59; pfam01883 266835012458 cell division ATPase MinD, archaeal; Region: minD_arch; TIGR01969 266835012459 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 266835012460 Walker A motif; other site 266835012461 Carbon monoxide dehydrogenase subunit G (CoxG); Region: CoxG; cd05018 266835012462 putative hydrophobic ligand binding site [chemical binding]; other site 266835012463 dihydroxy-acid dehydratase; Provisional; Region: PRK13017 266835012464 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 266835012465 active site residue [active] 266835012466 Uncharacterized conserved protein [Function unknown]; Region: COG4275 266835012467 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 266835012468 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 266835012469 Trimethylamine methyltransferase (MTTB); Region: MTTB; pfam06253 266835012470 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 266835012471 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266835012472 DNA-binding site [nucleotide binding]; DNA binding site 266835012473 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 266835012474 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266835012475 homodimer interface [polypeptide binding]; other site 266835012476 catalytic residue [active] 266835012477 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 266835012478 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 266835012479 active site 266835012480 dimer interface [polypeptide binding]; other site 266835012481 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 266835012482 dimer interface [polypeptide binding]; other site 266835012483 active site 266835012484 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 266835012485 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 266835012486 motif II; other site 266835012487 Predicted methyltransferase [General function prediction only]; Region: COG3897 266835012488 Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059 266835012489 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 266835012490 acyl-activating enzyme (AAE) consensus motif; other site 266835012491 putative AMP binding site [chemical binding]; other site 266835012492 putative active site [active] 266835012493 putative CoA binding site [chemical binding]; other site 266835012494 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 266835012495 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 266835012496 peptide binding site [polypeptide binding]; other site 266835012497 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 266835012498 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835012499 dimer interface [polypeptide binding]; other site 266835012500 conserved gate region; other site 266835012501 putative PBP binding loops; other site 266835012502 ABC-ATPase subunit interface; other site 266835012503 dipeptide transporter; Provisional; Region: PRK10913 266835012504 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835012505 dimer interface [polypeptide binding]; other site 266835012506 conserved gate region; other site 266835012507 putative PBP binding loops; other site 266835012508 ABC-ATPase subunit interface; other site 266835012509 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 266835012510 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266835012511 Walker A/P-loop; other site 266835012512 ATP binding site [chemical binding]; other site 266835012513 Q-loop/lid; other site 266835012514 ABC transporter signature motif; other site 266835012515 Walker B; other site 266835012516 D-loop; other site 266835012517 H-loop/switch region; other site 266835012518 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 266835012519 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 266835012520 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266835012521 Walker A/P-loop; other site 266835012522 ATP binding site [chemical binding]; other site 266835012523 Q-loop/lid; other site 266835012524 ABC transporter signature motif; other site 266835012525 Walker B; other site 266835012526 D-loop; other site 266835012527 H-loop/switch region; other site 266835012528 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 266835012529 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 266835012530 cysteine desulfurase family protein, VC1184 subfamily; Region: am_tr_V_VC1184; TIGR01976 266835012531 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 266835012532 catalytic residue [active] 266835012533 amine acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family; Region: HEQRo_perm_3TM; TIGR01726 266835012534 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835012535 putative PBP binding loops; other site 266835012536 dimer interface [polypeptide binding]; other site 266835012537 ABC-ATPase subunit interface; other site 266835012538 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 266835012539 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 266835012540 substrate binding pocket [chemical binding]; other site 266835012541 membrane-bound complex binding site; other site 266835012542 hinge residues; other site 266835012543 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836 266835012544 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 266835012545 active site 266835012546 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 266835012547 dimer interface [polypeptide binding]; other site 266835012548 non-prolyl cis peptide bond; other site 266835012549 insertion regions; other site 266835012550 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 266835012551 homotrimer interaction site [polypeptide binding]; other site 266835012552 putative active site [active] 266835012553 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 266835012554 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 266835012555 active site 266835012556 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 266835012557 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266835012558 substrate binding site [chemical binding]; other site 266835012559 oxyanion hole (OAH) forming residues; other site 266835012560 trimer interface [polypeptide binding]; other site 266835012561 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 266835012562 MarR family; Region: MarR; pfam01047 266835012563 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 266835012564 classical (c) SDRs; Region: SDR_c; cd05233 266835012565 NAD(P) binding site [chemical binding]; other site 266835012566 active site 266835012567 salicylyl-CoA 5-hydroxylase; Reviewed; Region: PRK08255 266835012568 hypothetical protein; Provisional; Region: PRK07236 266835012569 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 266835012570 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 266835012571 active site 266835012572 FMN binding site [chemical binding]; other site 266835012573 substrate binding site [chemical binding]; other site 266835012574 homotetramer interface [polypeptide binding]; other site 266835012575 catalytic residue [active] 266835012576 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266835012577 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 266835012578 active site 266835012579 metal binding site [ion binding]; metal-binding site 266835012580 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266835012581 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 266835012582 Walker A/P-loop; other site 266835012583 ATP binding site [chemical binding]; other site 266835012584 Q-loop/lid; other site 266835012585 ABC transporter signature motif; other site 266835012586 Walker B; other site 266835012587 D-loop; other site 266835012588 H-loop/switch region; other site 266835012589 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 266835012590 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266835012591 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 266835012592 Walker A/P-loop; other site 266835012593 ATP binding site [chemical binding]; other site 266835012594 Q-loop/lid; other site 266835012595 ABC transporter signature motif; other site 266835012596 Walker B; other site 266835012597 D-loop; other site 266835012598 H-loop/switch region; other site 266835012599 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 266835012600 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 266835012601 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835012602 dimer interface [polypeptide binding]; other site 266835012603 conserved gate region; other site 266835012604 putative PBP binding loops; other site 266835012605 ABC-ATPase subunit interface; other site 266835012606 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 266835012607 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 266835012608 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 266835012609 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_10; cd08515 266835012610 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 266835012611 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 266835012612 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 266835012613 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 266835012614 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 266835012615 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 266835012616 MarR family; Region: MarR_2; pfam12802 266835012617 MarR family; Region: MarR_2; cl17246 266835012618 Indolepyruvate ferredoxin oxidoreductase, alpha and beta subunits [Energy production and conversion]; Region: COG4231 266835012619 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 266835012620 PYR/PP interface [polypeptide binding]; other site 266835012621 dimer interface [polypeptide binding]; other site 266835012622 TPP binding site [chemical binding]; other site 266835012623 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 266835012624 TPP-binding site; other site 266835012625 putative indolepyruvate oxidoreductase subunit B; Reviewed; Region: PRK08312 266835012626 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 266835012627 acylglycerophosphoethanolamine acyltransferase; Provisional; Region: PRK06814 266835012628 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 266835012629 putative acyl-acceptor binding pocket; other site 266835012630 C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909 266835012631 acyl-activating enzyme (AAE) consensus motif; other site 266835012632 putative AMP binding site [chemical binding]; other site 266835012633 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4102 266835012634 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5267 266835012635 Predicted integral membrane protein [Function unknown]; Region: COG5612 266835012636 RNA polymerase sigma factor; Reviewed; Region: PRK05602 266835012637 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 266835012638 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 266835012639 DNA binding residues [nucleotide binding] 266835012640 EF-hand domain pair; Region: EF_hand_5; pfam13499 266835012641 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 266835012642 EF-hand domain pair; Region: EF_hand_5; pfam13499 266835012643 Ca2+ binding site [ion binding]; other site 266835012644 Uncharacterized small protein [Function unknown]; Region: COG5475 266835012645 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 266835012646 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 266835012647 active site 266835012648 Int/Topo IB signature motif; other site 266835012649 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 266835012650 RecA-family ATPase [DNA replication, recombination, and repair]; Region: RepA; COG3598 266835012651 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 266835012652 Walker A motif; other site 266835012653 ATP binding site [chemical binding]; other site 266835012654 Walker B motif; other site 266835012655 Family description; Region: UvrD_C_2; pfam13538 266835012656 Uncharacterized conserved protein [Function unknown]; Region: COG1262 266835012657 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 266835012658 Protein involved in meta-pathway of phenol degradation [Energy production and conversion]; Region: COG4313 266835012659 Uncharacterized conserved protein [Function unknown]; Region: COG5361 266835012660 Protein of unknown function (DUF1214); Region: DUF1214; pfam06742 266835012661 Uncharacterized conserved protein [Function unknown]; Region: COG5361 266835012662 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 266835012663 Uncharacterized conserved protein [Function unknown]; Region: COG5361 266835012664 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 266835012665 Protein of unknown function (DUF1214); Region: DUF1214; pfam06742 266835012666 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 266835012667 Sulfatase; Region: Sulfatase; pfam00884 266835012668 Predicted periplasmic protein [Function unknown]; Region: COG3900 266835012669 Phage terminase, small subunit [DNA replication, recombination, and repair]; Region: XtmA; COG3728 266835012670 DEAD-like helicases superfamily; Region: DEXDc; smart00487 266835012671 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 266835012672 ATP binding site [chemical binding]; other site 266835012673 putative Mg++ binding site [ion binding]; other site 266835012674 ATP-dependent DNA ligase; Validated; Region: PRK09247 266835012675 Adenylation domain of putative bacterial ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_Bac1; cd07897 266835012676 active site 266835012677 DNA binding site [nucleotide binding] 266835012678 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 266835012679 DNA binding site [nucleotide binding] 266835012680 putative exonuclease, DNA ligase-associated; Region: Xnuc_lig_assoc; TIGR04122 266835012681 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 266835012682 Predicted methyltransferase (contains TPR repeat) [General function prediction only]; Region: COG4976 266835012683 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 266835012684 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266835012685 S-adenosylmethionine binding site [chemical binding]; other site 266835012686 Adenylate kinase and related kinases [Nucleotide transport and metabolism]; Region: Adk; COG0563 266835012687 AAA domain; Region: AAA_17; pfam13207 266835012688 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 266835012689 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 266835012690 putative ligand binding site [chemical binding]; other site 266835012691 NAD binding site [chemical binding]; other site 266835012692 dimerization interface [polypeptide binding]; other site 266835012693 catalytic site [active] 266835012694 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 266835012695 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266835012696 Walker A/P-loop; other site 266835012697 ATP binding site [chemical binding]; other site 266835012698 Q-loop/lid; other site 266835012699 ABC transporter signature motif; other site 266835012700 Walker B; other site 266835012701 D-loop; other site 266835012702 H-loop/switch region; other site 266835012703 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 266835012704 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266835012705 Walker A/P-loop; other site 266835012706 ATP binding site [chemical binding]; other site 266835012707 Q-loop/lid; other site 266835012708 ABC transporter signature motif; other site 266835012709 Walker B; other site 266835012710 D-loop; other site 266835012711 H-loop/switch region; other site 266835012712 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 266835012713 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 266835012714 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835012715 dimer interface [polypeptide binding]; other site 266835012716 conserved gate region; other site 266835012717 putative PBP binding loops; other site 266835012718 ABC-ATPase subunit interface; other site 266835012719 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 266835012720 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835012721 dimer interface [polypeptide binding]; other site 266835012722 conserved gate region; other site 266835012723 putative PBP binding loops; other site 266835012724 ABC-ATPase subunit interface; other site 266835012725 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 266835012726 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 266835012727 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 266835012728 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 266835012729 Cytochrome c2 [Energy production and conversion]; Region: COG3474 266835012730 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 266835012731 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 266835012732 Ligand binding site; other site 266835012733 oligomer interface; other site 266835012734 prephenate dehydratase; Provisional; Region: PRK11899 266835012735 Prephenate dehydratase; Region: PDT; pfam00800 266835012736 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 266835012737 putative L-Phe binding site [chemical binding]; other site 266835012738 Stress responsive A/B Barrel Domain; Region: Dabb; pfam07876 266835012739 NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816 266835012740 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 266835012741 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 266835012742 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 266835012743 putative NADH binding site [chemical binding]; other site 266835012744 putative active site [active] 266835012745 nudix motif; other site 266835012746 putative metal binding site [ion binding]; other site 266835012747 HIT domain; Region: HIT; pfam01230 266835012748 nucleotide binding site/active site [active] 266835012749 HIT family signature motif; other site 266835012750 catalytic residue [active] 266835012751 DNA polymerase III subunits gamma and tau; Validated; Region: PRK09111 266835012752 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266835012753 Walker A motif; other site 266835012754 ATP binding site [chemical binding]; other site 266835012755 Walker B motif; other site 266835012756 arginine finger; other site 266835012757 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 266835012758 DNA polymerase III gamma and tau subunits C terminal; Region: DUF3646; pfam12362 266835012759 hypothetical protein; Validated; Region: PRK00153 266835012760 Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773 266835012761 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 266835012762 recombination protein RecR; Reviewed; Region: recR; PRK00076 266835012763 RecR protein; Region: RecR; pfam02132 266835012764 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 266835012765 putative active site [active] 266835012766 putative metal-binding site [ion binding]; other site 266835012767 tetramer interface [polypeptide binding]; other site 266835012768 lytic murein transglycosylase; Region: MltB_2; TIGR02283 266835012769 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 266835012770 N-acetyl-D-glucosamine binding site [chemical binding]; other site 266835012771 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 266835012772 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 266835012773 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 266835012774 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 266835012775 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835012776 dimer interface [polypeptide binding]; other site 266835012777 conserved gate region; other site 266835012778 putative PBP binding loops; other site 266835012779 ABC-ATPase subunit interface; other site 266835012780 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 266835012781 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835012782 dimer interface [polypeptide binding]; other site 266835012783 conserved gate region; other site 266835012784 ABC-ATPase subunit interface; other site 266835012785 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266835012786 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 266835012787 Walker A/P-loop; other site 266835012788 ATP binding site [chemical binding]; other site 266835012789 Q-loop/lid; other site 266835012790 ABC transporter signature motif; other site 266835012791 Walker B; other site 266835012792 D-loop; other site 266835012793 H-loop/switch region; other site 266835012794 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 266835012795 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 266835012796 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266835012797 Walker A/P-loop; other site 266835012798 ATP binding site [chemical binding]; other site 266835012799 Q-loop/lid; other site 266835012800 ABC transporter signature motif; other site 266835012801 Walker B; other site 266835012802 D-loop; other site 266835012803 H-loop/switch region; other site 266835012804 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 266835012805 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 266835012806 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 266835012807 HlyD family secretion protein; Region: HlyD_3; pfam13437 266835012808 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 266835012809 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 266835012810 4-aminobutyrate aminotransferase; Provisional; Region: PRK07495 266835012811 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 266835012812 inhibitor-cofactor binding pocket; inhibition site 266835012813 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266835012814 catalytic residue [active] 266835012815 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 266835012816 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 266835012817 Uncharacterized iron-regulated protein [Inorganic ion transport and metabolism]; Region: IrpA; COG3487 266835012818 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 266835012819 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 266835012820 heme binding site [chemical binding]; other site 266835012821 ferroxidase pore; other site 266835012822 ferroxidase diiron center [ion binding]; other site 266835012823 Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488 266835012824 Protein of unknown function (DUF1111); Region: DUF1111; pfam06537 266835012825 Predicted periplasmic lipoprotein [General function prediction only]; Region: COG3489 266835012826 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3490 266835012827 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 266835012828 Glycoprotease family; Region: Peptidase_M22; pfam00814 266835012829 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 266835012830 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 266835012831 Coenzyme A binding pocket [chemical binding]; other site 266835012832 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 266835012833 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 266835012834 putative acyl-acceptor binding pocket; other site 266835012835 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 266835012836 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 266835012837 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 266835012838 FeS/SAM binding site; other site 266835012839 TRAM domain; Region: TRAM; pfam01938 266835012840 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 266835012841 PhoH-like protein; Region: PhoH; pfam02562 266835012842 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG0319 266835012843 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 266835012844 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 266835012845 Transporter associated domain; Region: CorC_HlyC; smart01091 266835012846 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_14; cd08355 266835012847 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266835012848 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 266835012849 classical (c) SDRs; Region: SDR_c; cd05233 266835012850 NAD(P) binding site [chemical binding]; other site 266835012851 active site 266835012852 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266835012853 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266835012854 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_8; cd08477 266835012855 putative effector binding pocket; other site 266835012856 putative dimerization interface [polypeptide binding]; other site 266835012857 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 266835012858 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 266835012859 putative active site [active] 266835012860 catalytic triad [active] 266835012861 putative dimer interface [polypeptide binding]; other site 266835012862 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 266835012863 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266835012864 non-specific DNA binding site [nucleotide binding]; other site 266835012865 salt bridge; other site 266835012866 sequence-specific DNA binding site [nucleotide binding]; other site 266835012867 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 266835012868 S-adenosylmethionine synthetase; Validated; Region: PRK05250 266835012869 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 266835012870 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 266835012871 Predicted S-adenosylmethionine-dependent methyltransferase [General function prediction only]; Region: COG0220 266835012872 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG0779 266835012873 Sm and related proteins; Region: Sm_like; cl00259 266835012874 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 266835012875 putative oligomer interface [polypeptide binding]; other site 266835012876 putative RNA binding site [nucleotide binding]; other site 266835012877 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 266835012878 NusA N-terminal domain; Region: NusA_N; pfam08529 266835012879 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 266835012880 RNA binding site [nucleotide binding]; other site 266835012881 homodimer interface [polypeptide binding]; other site 266835012882 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 266835012883 G-X-X-G motif; other site 266835012884 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 266835012885 G-X-X-G motif; other site 266835012886 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 266835012887 hypothetical protein; Provisional; Region: PRK09190 266835012888 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 266835012889 putative RNA binding cleft [nucleotide binding]; other site 266835012890 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 266835012891 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 266835012892 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 266835012893 Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532 266835012894 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 266835012895 G1 box; other site 266835012896 putative GEF interaction site [polypeptide binding]; other site 266835012897 GTP/Mg2+ binding site [chemical binding]; other site 266835012898 Switch I region; other site 266835012899 G2 box; other site 266835012900 G3 box; other site 266835012901 Switch II region; other site 266835012902 G4 box; other site 266835012903 G5 box; other site 266835012904 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 266835012905 Translation-initiation factor 2; Region: IF-2; pfam11987 266835012906 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 266835012907 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 266835012908 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05389 266835012909 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 266835012910 RNA binding site [nucleotide binding]; other site 266835012911 active site 266835012912 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 266835012913 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 266835012914 Thermotoga maritima CorA_like subfamily; Region: TmCorA-like_1; cd12828 266835012915 oligomer interface [polypeptide binding]; other site 266835012916 metal binding site [ion binding]; metal-binding site 266835012917 metal binding site [ion binding]; metal-binding site 266835012918 Cl binding site [ion binding]; other site 266835012919 aspartate ring; other site 266835012920 basic sphincter; other site 266835012921 putative hydrophobic gate; other site 266835012922 periplasmic entrance; other site 266835012923 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 266835012924 16S/18S rRNA binding site [nucleotide binding]; other site 266835012925 S13e-L30e interaction site [polypeptide binding]; other site 266835012926 25S rRNA binding site [nucleotide binding]; other site 266835012927 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 266835012928 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 266835012929 RNase E interface [polypeptide binding]; other site 266835012930 trimer interface [polypeptide binding]; other site 266835012931 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 266835012932 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 266835012933 RNase E interface [polypeptide binding]; other site 266835012934 trimer interface [polypeptide binding]; other site 266835012935 active site 266835012936 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 266835012937 putative nucleic acid binding region [nucleotide binding]; other site 266835012938 G-X-X-G motif; other site 266835012939 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 266835012940 RNA binding site [nucleotide binding]; other site 266835012941 domain interface; other site 266835012942 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 266835012943 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266835012944 S-adenosylmethionine binding site [chemical binding]; other site 266835012945 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266835012946 metal binding site [ion binding]; metal-binding site 266835012947 active site 266835012948 I-site; other site 266835012949 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 266835012950 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK06505 266835012951 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 266835012952 NAD binding site [chemical binding]; other site 266835012953 homotetramer interface [polypeptide binding]; other site 266835012954 homodimer interface [polypeptide binding]; other site 266835012955 substrate binding site [chemical binding]; other site 266835012956 active site 266835012957 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 266835012958 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 266835012959 dimer interface [polypeptide binding]; other site 266835012960 active site 266835012961 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 266835012962 active site 1 [active] 266835012963 dimer interface [polypeptide binding]; other site 266835012964 active site 2 [active] 266835012965 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 266835012966 metal binding site 2 [ion binding]; metal-binding site 266835012967 putative DNA binding helix; other site 266835012968 metal binding site 1 [ion binding]; metal-binding site 266835012969 dimer interface [polypeptide binding]; other site 266835012970 structural Zn2+ binding site [ion binding]; other site 266835012971 Domain of unknown function (DUF4260); Region: DUF4260; pfam14079 266835012972 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3807 266835012973 Bacterial SH3 domain; Region: SH3_4; pfam06347 266835012974 Bacterial SH3 domain; Region: SH3_4; pfam06347 266835012975 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 266835012976 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 266835012977 dimerization interface [polypeptide binding]; other site 266835012978 ligand binding site [chemical binding]; other site 266835012979 NADP binding site [chemical binding]; other site 266835012980 catalytic site [active] 266835012981 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 266835012982 Coenzyme A binding pocket [chemical binding]; other site 266835012983 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 266835012984 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 266835012985 ATP binding site [chemical binding]; other site 266835012986 substrate interface [chemical binding]; other site 266835012987 recombination protein F; Reviewed; Region: recF; PRK00064 266835012988 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266835012989 Walker A/P-loop; other site 266835012990 ATP binding site [chemical binding]; other site 266835012991 Q-loop/lid; other site 266835012992 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266835012993 ABC transporter signature motif; other site 266835012994 Walker B; other site 266835012995 D-loop; other site 266835012996 H-loop/switch region; other site 266835012997 DNA polymerase III subunit beta; Validated; Region: PRK05643 266835012998 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 266835012999 putative DNA binding surface [nucleotide binding]; other site 266835013000 dimer interface [polypeptide binding]; other site 266835013001 beta-clamp/clamp loader binding surface; other site 266835013002 beta-clamp/translesion DNA polymerase binding surface; other site 266835013003 DnaA N-terminal domain; Region: DnaA_N; pfam11638 266835013004 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 266835013005 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 266835013006 Walker A motif; other site 266835013007 ATP binding site [chemical binding]; other site 266835013008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 266835013009 DnaA box-binding interface [nucleotide binding]; other site 266835013010 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 266835013011 enoyl-CoA hydratase; Provisional; Region: PRK05862 266835013012 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266835013013 substrate binding site [chemical binding]; other site 266835013014 oxyanion hole (OAH) forming residues; other site 266835013015 trimer interface [polypeptide binding]; other site 266835013016 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 266835013017 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 266835013018 DNA binding site [nucleotide binding] 266835013019 catalytic residue [active] 266835013020 H2TH interface [polypeptide binding]; other site 266835013021 putative catalytic residues [active] 266835013022 turnover-facilitating residue; other site 266835013023 intercalation triad [nucleotide binding]; other site 266835013024 8OG recognition residue [nucleotide binding]; other site 266835013025 putative reading head residues; other site 266835013026 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 266835013027 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 266835013028 phosphopentomutase; Provisional; Region: PRK05362 266835013029 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 266835013030 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 266835013031 Protein of unknown function (DUF2551); Region: DUF2551; pfam10826 266835013032 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 266835013033 TadE-like protein; Region: TadE; pfam07811 266835013034 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 266835013035 Flp/Fap pilin component; Region: Flp_Fap; cl01585 266835013036 Flp pilus assembly protein, protease CpaA [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: CpaA; COG4960 266835013037 Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745 266835013038 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 266835013039 Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964 266835013040 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 266835013041 BON domain; Region: BON; pfam04972 266835013042 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 266835013043 Type IV pili component [Cell motility and secretion]; Region: COG5461 266835013044 pilus (Caulobacter type) biogenesis lipoprotein CpaD; Region: pilus_cpaD; TIGR02522 266835013045 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 266835013046 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 266835013047 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 266835013048 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 266835013049 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 266835013050 ATP binding site [chemical binding]; other site 266835013051 Walker A motif; other site 266835013052 hexamer interface [polypeptide binding]; other site 266835013053 Walker B motif; other site 266835013054 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 266835013055 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 266835013056 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 266835013057 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 266835013058 Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking and secretion]; Region: TadD; COG5010 266835013059 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266835013060 binding surface 266835013061 TPR motif; other site 266835013062 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266835013063 TPR motif; other site 266835013064 binding surface 266835013065 Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260 266835013066 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 266835013067 interface (dimer of trimers) [polypeptide binding]; other site 266835013068 Substrate-binding/catalytic site; other site 266835013069 Zn-binding sites [ion binding]; other site 266835013070 Transcriptional regulators [Transcription]; Region: MarR; COG1846 266835013071 MarR family; Region: MarR; pfam01047 266835013072 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 266835013073 NlpC/P60 family; Region: NLPC_P60; cl17555 266835013074 DEXH box helicase, DNA ligase-associated; Region: DEXH_lig_assoc; TIGR04121 266835013075 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 266835013076 ATP binding site [chemical binding]; other site 266835013077 putative Mg++ binding site [ion binding]; other site 266835013078 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 266835013079 nucleotide binding region [chemical binding]; other site 266835013080 ATP-binding site [chemical binding]; other site 266835013081 DEAD/H associated; Region: DEAD_assoc; pfam08494 266835013082 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 266835013083 Pyrococcus furiosus PF1019 and related proteins, metallophosphatase domain; Region: MPP_PF1019; cd07391 266835013084 putative active site [active] 266835013085 putative metal binding site [ion binding]; other site 266835013086 DMSO reductase anchor subunit (DmsC); Region: DmsC; pfam04976 266835013087 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 266835013088 4Fe-4S binding domain; Region: Fer4; pfam00037 266835013089 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 266835013090 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 266835013091 molybdopterin cofactor binding site; other site 266835013092 The MopB_2 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members belong to...; Region: MopB_2; cd02763 266835013093 putative molybdopterin cofactor binding site [chemical binding]; other site 266835013094 The MopB_CT_2 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is...; Region: MopB_CT_2; cd02783 266835013095 putative molybdopterin cofactor binding site; other site 266835013096 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266835013097 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266835013098 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 266835013099 putative dimerization interface [polypeptide binding]; other site 266835013100 putative chaperone; Provisional; Region: PRK11678 266835013101 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 266835013102 nucleotide binding site [chemical binding]; other site 266835013103 putative NEF/HSP70 interaction site [polypeptide binding]; other site 266835013104 SBD interface [polypeptide binding]; other site 266835013105 Putative transmembrane protein (Alph_Pro_TM); Region: Alph_Pro_TM; pfam09608 266835013106 Predicted permeases [General function prediction only]; Region: COG0730 266835013107 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 266835013108 Sel1-like repeats; Region: SEL1; smart00671 266835013109 Sel1-like repeats; Region: SEL1; smart00671 266835013110 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 266835013111 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 266835013112 Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776 266835013113 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 266835013114 DNA binding residues [nucleotide binding] 266835013115 putative dimer interface [polypeptide binding]; other site 266835013116 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 266835013117 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 266835013118 Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153 266835013119 FAD binding site [chemical binding]; other site 266835013120 substrate binding site [chemical binding]; other site 266835013121 catalytic residues [active] 266835013122 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 266835013123 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 266835013124 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 266835013125 active site 266835013126 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 266835013127 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 266835013128 dimer interface [polypeptide binding]; other site 266835013129 active site 266835013130 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 266835013131 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266835013132 substrate binding site [chemical binding]; other site 266835013133 oxyanion hole (OAH) forming residues; other site 266835013134 trimer interface [polypeptide binding]; other site 266835013135 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 266835013136 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 266835013137 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 266835013138 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 266835013139 active site 266835013140 Predicted transcriptional regulator [Transcription]; Region: COG2932 266835013141 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 266835013142 Catalytic site [active] 266835013143 Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525 266835013144 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 266835013145 Catalytic site; other site 266835013146 lysyl-tRNA synthetase; Reviewed; Region: lysK; PRK00750 266835013147 catalytic core domain of class I lysyl tRNA synthetase; Region: LysRS_core_class_I; cd00674 266835013148 active site 266835013149 HIGH motif; other site 266835013150 KMSKS motif; other site 266835013151 tellurite resistance protein terB; Region: terB; cd07176 266835013152 putative metal binding site [ion binding]; other site 266835013153 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 266835013154 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 266835013155 substrate binding pocket [chemical binding]; other site 266835013156 membrane-bound complex binding site; other site 266835013157 hinge residues; other site 266835013158 LuxR family transcriptional regulatory, chaperone HchA-associated; Region: reg_near_HchA; TIGR03541 266835013159 Autoinducer binding domain; Region: Autoind_bind; pfam03472 266835013160 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266835013161 DNA binding residues [nucleotide binding] 266835013162 dimerization interface [polypeptide binding]; other site 266835013163 N-acyl-L-homoserine lactone synthetase [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: LasI; COG3916 266835013164 enoyl-CoA hydratase; Provisional; Region: PRK06688 266835013165 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266835013166 substrate binding site [chemical binding]; other site 266835013167 oxyanion hole (OAH) forming residues; other site 266835013168 trimer interface [polypeptide binding]; other site 266835013169 Uncharacterized conserved protein [Function unknown]; Region: COG2326 266835013170 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 266835013171 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266835013172 dimer interface [polypeptide binding]; other site 266835013173 phosphorylation site [posttranslational modification] 266835013174 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266835013175 ATP binding site [chemical binding]; other site 266835013176 Mg2+ binding site [ion binding]; other site 266835013177 G-X-G motif; other site 266835013178 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 266835013179 PhoU domain; Region: PhoU; pfam01895 266835013180 PhoU domain; Region: PhoU; pfam01895 266835013181 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 266835013182 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 266835013183 oligomer interface [polypeptide binding]; other site 266835013184 metal binding site [ion binding]; metal-binding site 266835013185 metal binding site [ion binding]; metal-binding site 266835013186 putative Cl binding site [ion binding]; other site 266835013187 basic sphincter; other site 266835013188 hydrophobic gate; other site 266835013189 periplasmic entrance; other site 266835013190 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5352 266835013191 acetylornithine transaminase protein; Provisional; Region: argD; PRK01278 266835013192 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 266835013193 inhibitor-cofactor binding pocket; inhibition site 266835013194 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266835013195 catalytic residue [active] 266835013196 ornithine carbamoyltransferase; Provisional; Region: PRK00779 266835013197 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 266835013198 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 266835013199 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 266835013200 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 266835013201 dimerization interface [polypeptide binding]; other site 266835013202 domain crossover interface; other site 266835013203 redox-dependent activation switch; other site 266835013204 Uncharacterized protein affecting Mg2+/Co2+ transport [Inorganic ion transport and metabolism]; Region: ApaG; COG2967 266835013205 Glucosylceramide synthase catalyzes the first glycosylation step of glycosphingolipid synthesis; Region: Glucosylceramide_synthase; cd02520 266835013206 ligand binding site; other site 266835013207 Glycosyl transferase family 21; Region: Glyco_transf_21; pfam13506 266835013208 O-succinylhomoserine sulfhydrylase; Reviewed; Region: PRK07504 266835013209 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 266835013210 homodimer interface [polypeptide binding]; other site 266835013211 substrate-cofactor binding pocket; other site 266835013212 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266835013213 catalytic residue [active] 266835013214 2'-deoxycytidine 5'-triphosphate deaminase; Provisional; Region: PRK07559 266835013215 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 266835013216 trimer interface [polypeptide binding]; other site 266835013217 active site 266835013218 Deoxycytidine deaminase [Nucleotide transport and metabolism]; Region: Dcd; COG0717 266835013219 trimer interface [polypeptide binding]; other site 266835013220 active site 266835013221 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 266835013222 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 266835013223 substrate binding pocket [chemical binding]; other site 266835013224 membrane-bound complex binding site; other site 266835013225 hinge residues; other site 266835013226 Uncharacterized protein conserved in bacteria [Function unknown]; Region: GguC; COG3802 266835013227 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 266835013228 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 266835013229 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 266835013230 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 266835013231 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 266835013232 TM-ABC transporter signature motif; other site 266835013233 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 266835013234 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 266835013235 Walker A/P-loop; other site 266835013236 ATP binding site [chemical binding]; other site 266835013237 Q-loop/lid; other site 266835013238 ABC transporter signature motif; other site 266835013239 Walker B; other site 266835013240 D-loop; other site 266835013241 H-loop/switch region; other site 266835013242 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 266835013243 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 266835013244 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 266835013245 putative ligand binding site [chemical binding]; other site 266835013246 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266835013247 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266835013248 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266835013249 dimerization interface [polypeptide binding]; other site 266835013250 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 266835013251 Adenylation domain of proteins similar to ATP-dependent polynucleotide ligases; Region: Adenylation_DNA_ligase_like; cl12015 266835013252 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266835013253 dimerization interface [polypeptide binding]; other site 266835013254 putative DNA binding site [nucleotide binding]; other site 266835013255 putative Zn2+ binding site [ion binding]; other site 266835013256 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 266835013257 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 266835013258 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 266835013259 Ligand binding site; other site 266835013260 Putative Catalytic site; other site 266835013261 DXD motif; other site 266835013262 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 266835013263 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266835013264 dimer interface [polypeptide binding]; other site 266835013265 phosphorylation site [posttranslational modification] 266835013266 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266835013267 ATP binding site [chemical binding]; other site 266835013268 Mg2+ binding site [ion binding]; other site 266835013269 G-X-G motif; other site 266835013270 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 266835013271 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266835013272 active site 266835013273 phosphorylation site [posttranslational modification] 266835013274 intermolecular recognition site; other site 266835013275 dimerization interface [polypeptide binding]; other site 266835013276 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266835013277 DNA binding site [nucleotide binding] 266835013278 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 266835013279 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 266835013280 Histone deacetylase class IV also known as histone deacetylase 11; Region: HDAC_classIV; cd09993 266835013281 putative active site [active] 266835013282 Zn binding site [ion binding]; other site 266835013283 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 266835013284 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 266835013285 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 266835013286 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 266835013287 quinone interaction residues [chemical binding]; other site 266835013288 active site 266835013289 catalytic residues [active] 266835013290 FMN binding site [chemical binding]; other site 266835013291 substrate binding site [chemical binding]; other site 266835013292 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3502 266835013293 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 266835013294 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266835013295 active site 266835013296 phosphorylation site [posttranslational modification] 266835013297 intermolecular recognition site; other site 266835013298 dimerization interface [polypeptide binding]; other site 266835013299 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266835013300 DNA binding residues [nucleotide binding] 266835013301 dimerization interface [polypeptide binding]; other site 266835013302 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266835013303 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 266835013304 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266835013305 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266835013306 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266835013307 dimerization interface [polypeptide binding]; other site 266835013308 Major Facilitator Superfamily; Region: MFS_1; pfam07690 266835013309 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266835013310 putative substrate translocation pore; other site 266835013311 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 266835013312 Methyltransferase domain; Region: Methyltransf_24; pfam13578 266835013313 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266835013314 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266835013315 Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591 266835013316 Na binding site [ion binding]; other site 266835013317 PAS fold; Region: PAS_7; pfam12860 266835013318 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 266835013319 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266835013320 dimer interface [polypeptide binding]; other site 266835013321 phosphorylation site [posttranslational modification] 266835013322 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266835013323 ATP binding site [chemical binding]; other site 266835013324 Mg2+ binding site [ion binding]; other site 266835013325 G-X-G motif; other site 266835013326 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 266835013327 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266835013328 active site 266835013329 phosphorylation site [posttranslational modification] 266835013330 intermolecular recognition site; other site 266835013331 dimerization interface [polypeptide binding]; other site 266835013332 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952 266835013333 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 266835013334 aspartate aminotransferase; Provisional; Region: PRK06108 266835013335 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 266835013336 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266835013337 homodimer interface [polypeptide binding]; other site 266835013338 catalytic residue [active] 266835013339 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 266835013340 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 266835013341 substrate-cofactor binding pocket; other site 266835013342 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266835013343 catalytic residue [active] 266835013344 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 266835013345 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 266835013346 NAD binding site [chemical binding]; other site 266835013347 homodimer interface [polypeptide binding]; other site 266835013348 active site 266835013349 substrate binding site [chemical binding]; other site 266835013350 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 266835013351 hydroxyglutarate oxidase; Provisional; Region: PRK11728 266835013352 Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457 266835013353 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase-like 1; Region: PLPDE_III_AR_like_1; cd06815 266835013354 active site 266835013355 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 266835013356 dimer interface [polypeptide binding]; other site 266835013357 substrate binding site [chemical binding]; other site 266835013358 catalytic residue [active] 266835013359 Arginase/agmatinase/formimionoglutamate hydrolase, arginase family [Amino acid transport and metabolism]; Region: SpeB; COG0010 266835013360 active site 266835013361 metal binding site [ion binding]; metal-binding site 266835013362 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 266835013363 Novosphingobium aromaticivorans carbohydrate kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_NaCK_like; cd07772 266835013364 N- and C-terminal domain interface [polypeptide binding]; other site 266835013365 putative active site [active] 266835013366 putative MgATP binding site [chemical binding]; other site 266835013367 putative catalytic site [active] 266835013368 metal binding site [ion binding]; metal-binding site 266835013369 putative carbohydrate binding site [chemical binding]; other site 266835013370 Uncharacterized conserved protein [Function unknown]; Region: COG3254 266835013371 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 266835013372 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 266835013373 TM-ABC transporter signature motif; other site 266835013374 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 266835013375 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 266835013376 TM-ABC transporter signature motif; other site 266835013377 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 266835013378 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 266835013379 Walker A/P-loop; other site 266835013380 ATP binding site [chemical binding]; other site 266835013381 Q-loop/lid; other site 266835013382 ABC transporter signature motif; other site 266835013383 Walker B; other site 266835013384 D-loop; other site 266835013385 H-loop/switch region; other site 266835013386 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 266835013387 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 266835013388 rhamnose ABC transporter, rhamnose-binding protein; Region: RhaS; TIGR02637 266835013389 ligand binding site [chemical binding]; other site 266835013390 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 266835013391 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 266835013392 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 266835013393 short chain dehydrogenase; Validated; Region: PRK08324 266835013394 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007 266835013395 rhamnulose-1-phosphate aldolase/alcohol dehydrogenase, classical (c) SDRs; Region: R1PA_ADH_SDR_c; cd08943 266835013396 putative NAD(P) binding site [chemical binding]; other site 266835013397 active site 266835013398 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952 266835013399 L-rhamnose catabolism isomerase, Pseudomonas stutzeri subtype; Region: L_rham_iso_rhiz; TIGR02629 266835013400 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 266835013401 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 266835013402 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 266835013403 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 266835013404 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 266835013405 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 266835013406 tetramerization interface [polypeptide binding]; other site 266835013407 NAD(P) binding site [chemical binding]; other site 266835013408 catalytic residues [active] 266835013409 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 266835013410 6-hydroxyhexanoate dehydrogenase (HHD) catalyzes the oxidation of 6-hydroxyhexanoate to 6-oxohexanoate; Region: HHD; cd08191 266835013411 putative active site [active] 266835013412 metal binding site [ion binding]; metal-binding site 266835013413 Transcriptional regulators [Transcription]; Region: GntR; COG1802 266835013414 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266835013415 DNA-binding site [nucleotide binding]; DNA binding site 266835013416 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 266835013417 intracellular protease, PfpI family; Region: PfpI; TIGR01382 266835013418 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 266835013419 conserved cys residue [active] 266835013420 conjugal transfer relaxase TraA; Provisional; Region: PRK13889 266835013421 MobA/MobL family; Region: MobA_MobL; pfam03389 266835013422 AAA domain; Region: AAA_30; pfam13604 266835013423 Family description; Region: UvrD_C_2; pfam13538 266835013424 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3753 266835013425 Protein of unknown function (DUF768); Region: DUF768; pfam05589 266835013426 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3216 266835013427 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266835013428 S-adenosylmethionine binding site [chemical binding]; other site 266835013429 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG5278 266835013430 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 266835013431 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 266835013432 dimer interface [polypeptide binding]; other site 266835013433 phosphorylation site [posttranslational modification] 266835013434 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266835013435 ATP binding site [chemical binding]; other site 266835013436 Mg2+ binding site [ion binding]; other site 266835013437 G-X-G motif; other site 266835013438 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 266835013439 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266835013440 active site 266835013441 phosphorylation site [posttranslational modification] 266835013442 intermolecular recognition site; other site 266835013443 dimerization interface [polypeptide binding]; other site 266835013444 Response regulator receiver domain; Region: Response_reg; pfam00072 266835013445 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266835013446 active site 266835013447 phosphorylation site [posttranslational modification] 266835013448 intermolecular recognition site; other site 266835013449 dimerization interface [polypeptide binding]; other site 266835013450 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 266835013451 Histidine kinase; Region: HisKA_2; pfam07568 266835013452 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266835013453 ATP binding site [chemical binding]; other site 266835013454 Mg2+ binding site [ion binding]; other site 266835013455 G-X-G motif; other site 266835013456 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 266835013457 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 266835013458 ligand binding site [chemical binding]; other site 266835013459 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 266835013460 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 266835013461 similar to Large-conductance mechanosensitive channel 266835013462 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3753 266835013463 Bacterial lipocalin [Cell envelope biogenesis, outer membrane]; Region: Blc; COG3040 266835013464 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 266835013465 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 266835013466 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 266835013467 Integrase core domain; Region: rve; pfam00665 266835013468 Integrase core domain; Region: rve_3; pfam13683 266835013469 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 266835013470 metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459 266835013471 oligomer interface [polypeptide binding]; other site 266835013472 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 266835013473 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266835013474 non-specific DNA binding site [nucleotide binding]; other site 266835013475 salt bridge; other site 266835013476 sequence-specific DNA binding site [nucleotide binding]; other site 266835013477 integrase; Provisional; Region: PRK09692 266835013478 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 266835013479 active site 266835013480 Int/Topo IB signature motif; other site 266835013481 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 266835013482 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 266835013483 PYR/PP interface [polypeptide binding]; other site 266835013484 dimer interface [polypeptide binding]; other site 266835013485 TPP binding site [chemical binding]; other site 266835013486 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 266835013487 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 266835013488 TPP-binding site [chemical binding]; other site 266835013489 dimer interface [polypeptide binding]; other site 266835013490 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 266835013491 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835013492 NAD(P) binding site [chemical binding]; other site 266835013493 active site 266835013494 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 266835013495 Amidohydrolase; Region: Amidohydro_2; pfam04909 266835013496 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_10; cd06319 266835013497 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 266835013498 putative ligand binding site [chemical binding]; other site 266835013499 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 266835013500 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 266835013501 TM-ABC transporter signature motif; other site 266835013502 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 266835013503 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 266835013504 Walker A/P-loop; other site 266835013505 ATP binding site [chemical binding]; other site 266835013506 Q-loop/lid; other site 266835013507 ABC transporter signature motif; other site 266835013508 Walker B; other site 266835013509 D-loop; other site 266835013510 H-loop/switch region; other site 266835013511 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 266835013512 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 266835013513 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266835013514 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 266835013515 dimerization interface [polypeptide binding]; other site 266835013516 substrate binding pocket [chemical binding]; other site 266835013517 Transposase; Region: HTH_Tnp_1; cl17663 266835013518 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 266835013519 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 266835013520 catalytic residues [active] 266835013521 hypothetical protein; Validated; Region: PRK09169 266835013522 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 266835013523 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 266835013524 dimerization interface [polypeptide binding]; other site 266835013525 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266835013526 ATP binding site [chemical binding]; other site 266835013527 Mg2+ binding site [ion binding]; other site 266835013528 G-X-G motif; other site 266835013529 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 266835013530 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266835013531 active site 266835013532 phosphorylation site [posttranslational modification] 266835013533 intermolecular recognition site; other site 266835013534 dimerization interface [polypeptide binding]; other site 266835013535 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266835013536 DNA binding site [nucleotide binding] 266835013537 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 266835013538 Protein export membrane protein; Region: SecD_SecF; cl14618 266835013539 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 266835013540 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 266835013541 HlyD family secretion protein; Region: HlyD_3; pfam13437 266835013542 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 266835013543 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 266835013544 GAF domain; Region: GAF; cl17456 266835013545 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 266835013546 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 266835013547 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266835013548 homodimer interface [polypeptide binding]; other site 266835013549 catalytic residue [active] 266835013550 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 266835013551 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 266835013552 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 266835013553 dimer interface [polypeptide binding]; other site 266835013554 substrate binding site [chemical binding]; other site 266835013555 ATP binding site [chemical binding]; other site 266835013556 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 266835013557 thiamine phosphate binding site [chemical binding]; other site 266835013558 active site 266835013559 pyrophosphate binding site [ion binding]; other site 266835013560 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 266835013561 ThiS interaction site; other site 266835013562 putative active site [active] 266835013563 tetramer interface [polypeptide binding]; other site 266835013564 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 266835013565 thiS-thiF/thiG interaction site; other site 266835013566 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 266835013567 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 266835013568 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 266835013569 ThiC-associated domain; Region: ThiC-associated; pfam13667 266835013570 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 266835013571 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 266835013572 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 266835013573 6-pyruvoyl-tetrahydropterin synthase [Coenzyme metabolism]; Region: COG0720 266835013574 active site 266835013575 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 266835013576 Ligand Binding Site [chemical binding]; other site 266835013577 Fic family protein [Function unknown]; Region: COG3177 266835013578 Fic/DOC family; Region: Fic; pfam02661 266835013579 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 266835013580 ManB is a bacterial phosphomannomutase (PMM) that catalyzes the conversion of mannose 6-phosphate to mannose-1-phosphate in the second of three steps in the GDP-mannose pathway, in which GDP-D-mannose is synthesized from fructose-6-phosphate. In...; Region: ManB; cd03088 266835013581 active site 266835013582 substrate binding site [chemical binding]; other site 266835013583 metal binding site [ion binding]; metal-binding site 266835013584 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 266835013585 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 266835013586 Substrate binding site; other site 266835013587 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 266835013588 Restriction alleviation protein Lar; Region: Lar_restr_allev; pfam14354 266835013589 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 266835013590 Transposase; Region: HTH_Tnp_1; cl17663 266835013591 succinic semialdehyde dehydrogenase; Region: PLN02278 266835013592 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 266835013593 tetramerization interface [polypeptide binding]; other site 266835013594 NAD(P) binding site [chemical binding]; other site 266835013595 catalytic residues [active] 266835013596 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 266835013597 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 266835013598 ring oligomerisation interface [polypeptide binding]; other site 266835013599 ATP/Mg binding site [chemical binding]; other site 266835013600 stacking interactions; other site 266835013601 hinge regions; other site 266835013602 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 266835013603 oligomerisation interface [polypeptide binding]; other site 266835013604 mobile loop; other site 266835013605 roof hairpin; other site 266835013606 Transposase and inactivated derivatives, TnpA family [DNA replication, recombination, and repair]; Region: COG4644 266835013607 Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162 266835013608 coproporphyrinogen III oxidase; Provisional; Region: PRK13347 266835013609 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 266835013610 FeS/SAM binding site; other site 266835013611 HemN C-terminal domain; Region: HemN_C; pfam06969 266835013612 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 266835013613 Prolyl oligopeptidase, N-terminal beta-propeller domain; Region: Peptidase_S9_N; pfam02897 266835013614 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 266835013615 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 266835013616 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 266835013617 dimer interface [polypeptide binding]; other site 266835013618 active site 266835013619 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266835013620 Raffinose synthase or seed inhibition protein Sip1; Region: Raffinose_syn; pfam05691 266835013621 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 266835013622 tetramerization interface [polypeptide binding]; other site 266835013623 active site 266835013624 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK05963 266835013625 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 266835013626 dimer interface [polypeptide binding]; other site 266835013627 active site 266835013628 CoA binding pocket [chemical binding]; other site 266835013629 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964 266835013630 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 266835013631 inhibitor-cofactor binding pocket; inhibition site 266835013632 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266835013633 catalytic residue [active] 266835013634 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 266835013635 AAA domain; Region: AAA_26; pfam13500 266835013636 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 266835013637 hypothetical protein; Provisional; Region: PRK07505 266835013638 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 266835013639 catalytic residue [active] 266835013640 Biotin synthase and related enzymes [Coenzyme metabolism]; Region: BioB; COG0502 266835013641 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 266835013642 FeS/SAM binding site; other site 266835013643 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 266835013644 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK06106 266835013645 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 266835013646 dimerization interface [polypeptide binding]; other site 266835013647 active site 266835013648 L-aspartate oxidase; Provisional; Region: PRK07512 266835013649 L-aspartate oxidase; Provisional; Region: PRK06175 266835013650 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 266835013651 quinolinate synthetase; Provisional; Region: PRK09375 266835013652 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 266835013653 Nif-specific regulatory protein; Region: nifA; TIGR01817 266835013654 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 266835013655 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266835013656 Walker A motif; other site 266835013657 ATP binding site [chemical binding]; other site 266835013658 Walker B motif; other site 266835013659 arginine finger; other site 266835013660 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 266835013661 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 266835013662 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 266835013663 DNA binding site [nucleotide binding] 266835013664 Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307 266835013665 putative ligand binding site [chemical binding]; other site 266835013666 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 266835013667 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 266835013668 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 266835013669 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266835013670 dimer interface [polypeptide binding]; other site 266835013671 phosphorylation site [posttranslational modification] 266835013672 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266835013673 ATP binding site [chemical binding]; other site 266835013674 Mg2+ binding site [ion binding]; other site 266835013675 G-X-G motif; other site 266835013676 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 266835013677 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266835013678 active site 266835013679 phosphorylation site [posttranslational modification] 266835013680 intermolecular recognition site; other site 266835013681 dimerization interface [polypeptide binding]; other site 266835013682 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266835013683 Walker A motif; other site 266835013684 ATP binding site [chemical binding]; other site 266835013685 Walker B motif; other site 266835013686 arginine finger; other site 266835013687 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 266835013688 Integrase core domain; Region: rve_3; cl15866 266835013689 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 266835013690 Nodulation protein Z (NodZ); Region: NodZ; pfam05830 266835013691 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 266835013692 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 266835013693 NADP-binding site; other site 266835013694 homotetramer interface [polypeptide binding]; other site 266835013695 substrate binding site [chemical binding]; other site 266835013696 homodimer interface [polypeptide binding]; other site 266835013697 active site 266835013698 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 266835013699 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 266835013700 NADP binding site [chemical binding]; other site 266835013701 active site 266835013702 putative substrate binding site [chemical binding]; other site 266835013703 SIR2-like domain; Region: SIR2_2; pfam13289 266835013704 Nitrogen fixation protein [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NifU; COG5554 266835013705 NifZ domain; Region: NifZ; pfam04319 266835013706 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 266835013707 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 266835013708 nitrogenase cofactor biosynthesis protein NifB; Region: nifB; TIGR01290 266835013709 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 266835013710 FeS/SAM binding site; other site 266835013711 NifB belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme as part of...; Region: NifB; cd00852 266835013712 Nif-specific regulatory protein; Region: nifA; TIGR01817 266835013713 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 266835013714 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266835013715 Walker A motif; other site 266835013716 ATP binding site [chemical binding]; other site 266835013717 Walker B motif; other site 266835013718 arginine finger; other site 266835013719 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 266835013720 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 266835013721 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 266835013722 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 266835013723 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 266835013724 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 266835013725 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 266835013726 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 266835013727 Ligand binding site [chemical binding]; other site 266835013728 Electron transfer flavoprotein domain; Region: ETF; pfam01012 266835013729 nitrogenase stabilizing/protective protein; Provisional; Region: nifW; PRK00810 266835013730 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 266835013731 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 266835013732 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 266835013733 catalytic residue [active] 266835013734 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 266835013735 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 266835013736 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 266835013737 Walker A/P-loop; other site 266835013738 ATP binding site [chemical binding]; other site 266835013739 Q-loop/lid; other site 266835013740 ABC transporter signature motif; other site 266835013741 Walker B; other site 266835013742 D-loop; other site 266835013743 H-loop/switch region; other site 266835013744 Uncharacterized conserved small protein containing a coiled-coil domain [Function unknown]; Region: COG5420 266835013745 ferredoxin III, nif-specific; Region: fdxN_nitrog; TIGR02936 266835013746 NifQ; Region: NifQ; pfam04891 266835013747 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 266835013748 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 266835013749 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 266835013750 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 266835013751 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 266835013752 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 266835013753 catalytic triad [active] 266835013754 dimer interface [polypeptide binding]; other site 266835013755 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 266835013756 Cytochrome P450; Region: p450; cl12078 266835013757 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 266835013758 classical (c) SDRs; Region: SDR_c; cd05233 266835013759 NAD(P) binding site [chemical binding]; other site 266835013760 active site 266835013761 classical (c) SDRs; Region: SDR_c; cd05233 266835013762 NAD(P) binding site [chemical binding]; other site 266835013763 classical (c) SDRs; Region: SDR_c; cd05233 266835013764 active site 266835013765 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 266835013766 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 266835013767 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 266835013768 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 266835013769 tetramer interface [polypeptide binding]; other site 266835013770 active site 266835013771 Mg2+/Mn2+ binding site [ion binding]; other site 266835013772 aspartate aminotransferase; Provisional; Region: PRK05764 266835013773 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 266835013774 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266835013775 homodimer interface [polypeptide binding]; other site 266835013776 catalytic residue [active] 266835013777 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 266835013778 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 266835013779 active site 266835013780 metal-binding site 266835013781 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 266835013782 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266835013783 S-adenosylmethionine binding site [chemical binding]; other site 266835013784 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 266835013785 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 266835013786 active site 266835013787 dimer interface [polypeptide binding]; other site 266835013788 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 266835013789 Ligand Binding Site [chemical binding]; other site 266835013790 Molecular Tunnel; other site 266835013791 Uncharacterized proteins of the AP superfamily [General function prediction only]; Region: COG1524 266835013792 Sulfatase; Region: Sulfatase; cl17466 266835013793 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 266835013794 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 266835013795 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266835013796 homodimer interface [polypeptide binding]; other site 266835013797 catalytic residue [active] 266835013798 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 266835013799 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 266835013800 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 266835013801 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 266835013802 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_10; cd08515 266835013803 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 266835013804 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266835013805 Walker A/P-loop; other site 266835013806 ATP binding site [chemical binding]; other site 266835013807 Q-loop/lid; other site 266835013808 ABC transporter signature motif; other site 266835013809 Walker B; other site 266835013810 D-loop; other site 266835013811 H-loop/switch region; other site 266835013812 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 266835013813 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 266835013814 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266835013815 Walker A/P-loop; other site 266835013816 ATP binding site [chemical binding]; other site 266835013817 Q-loop/lid; other site 266835013818 ABC transporter signature motif; other site 266835013819 Walker B; other site 266835013820 D-loop; other site 266835013821 H-loop/switch region; other site 266835013822 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 266835013823 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 266835013824 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835013825 dimer interface [polypeptide binding]; other site 266835013826 conserved gate region; other site 266835013827 putative PBP binding loops; other site 266835013828 ABC-ATPase subunit interface; other site 266835013829 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 266835013830 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835013831 dimer interface [polypeptide binding]; other site 266835013832 conserved gate region; other site 266835013833 putative PBP binding loops; other site 266835013834 ABC-ATPase subunit interface; other site 266835013835 Family description; Region: UvrD_C_2; pfam13538 266835013836 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 266835013837 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 266835013838 diacylglycerol kinase; Reviewed; Region: PRK11914 266835013839 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 266835013840 oligomeric interface; other site 266835013841 putative active site [active] 266835013842 homodimer interface [polypeptide binding]; other site 266835013843 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 266835013844 Transposase; Region: DEDD_Tnp_IS110; pfam01548 266835013845 nitrogenase reductase; Reviewed; Region: nifH; PRK13234 266835013846 NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040 266835013847 Nucleotide-binding sites [chemical binding]; other site 266835013848 Walker A motif; other site 266835013849 Switch I region of nucleotide binding site; other site 266835013850 Fe4S4 binding sites [ion binding]; other site 266835013851 Switch II region of nucleotide binding site; other site 266835013852 Nitrogenase molybdenum-iron protein, alpha and beta chains [Energy production and conversion]; Region: NifD; COG2710 266835013853 Nitrogenase_MoFe_alpha_II: Nitrogenase MoFe protein, beta subunit. A group of proteins similar to the alpha subunit of the MoFe protein of the molybdenum (Mo-) nitrogenase. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to...; Region: Nitrogenase_MoFe_alpha; cd01976 266835013854 MoFe protein alpha/beta subunit interactions; other site 266835013855 Alpha subunit P cluster binding residues; other site 266835013856 FeMoco binding residues [chemical binding]; other site 266835013857 MoFe protein alpha subunit/Fe protein contacts; other site 266835013858 MoFe protein dimer/ dimer interactions; other site 266835013859 nitrogenase molybdenum-iron protein beta chain; Region: nifK; TIGR01286 266835013860 Domain of unknown function (DUF3364); Region: DUF3364; pfam11844 266835013861 Nitrogenase_MoFe_beta: Nitrogenase MoFe protein, beta subunit. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to ammonia. The Molybdenum (Mo-) nitrogenase is the most widespread and best characterized of these systems; Region: Nitrogenase_MoFe_beta; cd01974 266835013862 MoFe protein beta/alpha subunit interactions; other site 266835013863 Beta subunit P cluster binding residues; other site 266835013864 MoFe protein beta subunit/Fe protein contacts; other site 266835013865 MoFe protein dimer/ dimer interactions; other site 266835013866 nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283 266835013867 Nitrogenase_NifE_I: a subgroup of the NifE subunit of the NifEN complex: NifE forms an alpha2beta2 tetramer with NifN. NifE and NifN are structurally homologous to nitrogenase MoFe protein alpha and beta subunits respectively. NifEN participates in the...; Region: Nitrogenase_NifE_I; cd01968 266835013868 Nitrogenase_nifN1: A subgroup of the NifN subunit of the NifEN complex: NifN forms an alpha2beta2 tetramer with NifE. NifN and nifE are structurally homologous to nitrogenase MoFe protein beta and alpha subunits respectively. NifEN participates in the...; Region: Nitrogenase_NifN_1; cd01966 266835013869 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 266835013870 NifX belongs to a family of iron-molybdenum cluster-binding proteins that includes NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. The protein...; Region: NifX; cd00853 266835013871 probable nitrogen fixation protein; Region: TIGR02935 266835013872 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 266835013873 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266835013874 active site 266835013875 phosphorylation site [posttranslational modification] 266835013876 intermolecular recognition site; other site 266835013877 dimerization interface [polypeptide binding]; other site 266835013878 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266835013879 DNA binding site [nucleotide binding] 266835013880 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 266835013881 Ligand Binding Site [chemical binding]; other site 266835013882 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 266835013883 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 266835013884 active site 266835013885 acetoacetate decarboxylase; Provisional; Region: PRK02265 266835013886 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 266835013887 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835013888 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 266835013889 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 266835013890 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 266835013891 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 266835013892 Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: MetG; COG0143 266835013893 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 266835013894 active site 266835013895 HIGH motif; other site 266835013896 nucleotide binding site [chemical binding]; other site 266835013897 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 266835013898 active site 266835013899 KMSKS motif; other site 266835013900 Uncharacterized conserved small protein containing a coiled-coil domain [Function unknown]; Region: COG5420 266835013901 ferredoxin III, nif-specific; Region: fdxN_nitrog; TIGR02936 266835013902 1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism]; Region: Acd; COG2515 266835013903 Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449 266835013904 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266835013905 catalytic residue [active] 266835013906 similar to Transcriptional regulator 266835013907 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 266835013908 Ligand Binding Site [chemical binding]; other site 266835013909 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 266835013910 active site 266835013911 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 266835013912 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 266835013913 FeS/SAM binding site; other site 266835013914 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 266835013915 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 266835013916 trimerization site [polypeptide binding]; other site 266835013917 active site 266835013918 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049 266835013919 diaminobutyrate--2-oxoglutarate aminotransferase; Region: ectoine_ectB; TIGR02407 266835013920 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 266835013921 inhibitor-cofactor binding pocket; inhibition site 266835013922 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266835013923 catalytic residue [active] 266835013924 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 266835013925 Transposase; Region: HTH_Tnp_1; pfam01527 266835013926 HTH-like domain; Region: HTH_21; pfam13276 266835013927 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 266835013928 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 266835013929 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 266835013930 Integrase core domain; Region: rve; pfam00665 266835013931 Integrase core domain; Region: rve_3; pfam13683 266835013932 Autoinducer binding domain; Region: Autoind_bind; pfam03472 266835013933 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266835013934 DNA binding residues [nucleotide binding] 266835013935 dimerization interface [polypeptide binding]; other site 266835013936 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 266835013937 INT_SG5, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 5, N- and C-terminal domains. The CD contains mainly predicted bacterial integrase/recombinases; Region: INT_SG5; cd01190 266835013938 Int/Topo IB signature motif; other site 266835013939 INT_SG4, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 4, N- and C-terminal domains. The CD contains mainly predicted bacterial integrase/recombinases for which not much biochemical characterization is available; Region: INT_SG4; cd01187 266835013940 Int/Topo IB signature motif; other site 266835013941 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 266835013942 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; pfam02899 266835013943 pAE1 and related integrases, DNA breaking-rejoining enzymes, integrase/recombinases, C-terminal domain. This CD includes various bacterial integrases, including the predicted integrase of the deletion-prone region of plasmid pAE1 of Alcaligenes eutrophus...; Region: INT_pAE1; cd01188 266835013944 Int/Topo IB signature motif; other site 266835013945 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 266835013946 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 266835013947 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 266835013948 Transposase; Region: DDE_Tnp_ISL3; pfam01610 266835013949 Biotin carboxylase [Lipid metabolism]; Region: AccC; COG0439 266835013950 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 266835013951 Transposase; Region: DEDD_Tnp_IS110; pfam01548 266835013952 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 266835013953 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 266835013954 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 266835013955 Transposase; Region: DEDD_Tnp_IS110; pfam01548 266835013956 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 266835013957 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 266835013958 Transposase; Region: DEDD_Tnp_IS110; pfam01548 266835013959 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 266835013960 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 266835013961 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 266835013962 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 266835013963 Transposase, Mutator family; Region: Transposase_mut; pfam00872 266835013964 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 266835013965 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 266835013966 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 266835013967 active site 266835013968 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 266835013969 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 266835013970 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 266835013971 Transposase; Region: HTH_Tnp_1; pfam01527 266835013972 HTH-like domain; Region: HTH_21; pfam13276 266835013973 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 266835013974 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 266835013975 DNA binding site [nucleotide binding] 266835013976 active site 266835013977 Int/Topo IB signature motif; other site 266835013978 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 266835013979 Transposase; Region: DEDD_Tnp_IS110; pfam01548 266835013980 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 266835013981 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 266835013982 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 266835013983 FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659 266835013984 Transposase; Region: DEDD_Tnp_IS110; pfam01548 266835013985 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 266835013986 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 266835013987 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 266835013988 Transposase; Region: DEDD_Tnp_IS110; pfam01548 266835013989 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 266835013990 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 266835013991 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 266835013992 Coenzyme A binding pocket [chemical binding]; other site 266835013993 putative aminotransferase; Validated; Region: PRK07480 266835013994 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 266835013995 inhibitor-cofactor binding pocket; inhibition site 266835013996 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266835013997 catalytic residue [active] 266835013998 Uncharacterized conserved protein [Function unknown]; Region: COG5476 266835013999 Protein of unknown function (DUF1485); Region: DUF1485; pfam07364 266835014000 MlrC C-terminus; Region: MlrC_C; pfam07171 266835014001 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 266835014002 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 266835014003 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 266835014004 putative active site [active] 266835014005 hypothetical protein; Provisional; Region: PRK07483 266835014006 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 266835014007 inhibitor-cofactor binding pocket; inhibition site 266835014008 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266835014009 catalytic residue [active] 266835014010 Transposase, Mutator family; Region: Transposase_mut; pfam00872 266835014011 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 266835014012 Transposase; Region: DEDD_Tnp_IS110; pfam01548 266835014013 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 266835014014 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 266835014015 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 266835014016 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 266835014017 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 266835014018 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 266835014019 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 266835014020 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 266835014021 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 266835014022 AAA domain; Region: AAA_26; pfam13500 266835014023 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 266835014024 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 266835014025 catalytic residue [active] 266835014026 biotin synthase; Region: bioB; TIGR00433 266835014027 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 266835014028 FeS/SAM binding site; other site 266835014029 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 266835014030 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 266835014031 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 266835014032 similar to Predicted acyl dehydratase 266835014033 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 266835014034 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 266835014035 ATP-grasp domain; Region: ATP-grasp_4; cl17255 266835014036 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 266835014037 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 266835014038 carboxyltransferase (CT) interaction site; other site 266835014039 biotinylation site [posttranslational modification]; other site 266835014040 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 266835014041 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 266835014042 enoyl-CoA hydratase; Provisional; Region: PRK08252 266835014043 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266835014044 substrate binding site [chemical binding]; other site 266835014045 oxyanion hole (OAH) forming residues; other site 266835014046 trimer interface [polypeptide binding]; other site 266835014047 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 266835014048 Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); Region: MACS_like_3; cd05971 266835014049 active site 266835014050 acyl-activating enzyme (AAE) consensus motif; other site 266835014051 putative CoA binding site [chemical binding]; other site 266835014052 AMP binding site [chemical binding]; other site 266835014053 hypothetical protein; Provisional; Region: PRK08201 266835014054 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680 266835014055 metal binding site [ion binding]; metal-binding site 266835014056 putative dimer interface [polypeptide binding]; other site 266835014057 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 266835014058 Methylaspartate ammonia-lyase [Amino acid transport and metabolism]; Region: Mal; COG3799 266835014059 Methylaspartate ammonia-lyase N-terminus; Region: MAAL_N; pfam05034 266835014060 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 266835014061 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 266835014062 inhibitor-cofactor binding pocket; inhibition site 266835014063 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266835014064 catalytic residue [active] 266835014065 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 266835014066 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 266835014067 active site 266835014068 ATP binding site [chemical binding]; other site 266835014069 substrate binding site [chemical binding]; other site 266835014070 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 266835014071 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 266835014072 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 266835014073 active site 266835014074 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 266835014075 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 266835014076 Transposase; Region: DEDD_Tnp_IS110; pfam01548 266835014077 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 266835014078 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 266835014079 FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659 266835014080 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 266835014081 Integrase core domain; Region: rve; pfam00665 266835014082 Putative zinc-finger; Region: zf-HC2; pfam13490 266835014083 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266835014084 Walker A motif; other site 266835014085 ATP binding site [chemical binding]; other site 266835014086 Walker B motif; other site 266835014087 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 266835014088 active site 266835014089 DNA binding site [nucleotide binding] 266835014090 Int/Topo IB signature motif; other site 266835014091 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 266835014092 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 266835014093 active site 266835014094 Int/Topo IB signature motif; other site 266835014095 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 266835014096 INT_SG5, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 5, N- and C-terminal domains. The CD contains mainly predicted bacterial integrase/recombinases; Region: INT_SG5; cd01190 266835014097 Int/Topo IB signature motif; other site 266835014098 INT_SG4, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 4, N- and C-terminal domains. The CD contains mainly predicted bacterial integrase/recombinases for which not much biochemical characterization is available; Region: INT_SG4; cd01187 266835014099 Int/Topo IB signature motif; other site 266835014100 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 266835014101 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; pfam02899 266835014102 pAE1 and related integrases, DNA breaking-rejoining enzymes, integrase/recombinases, C-terminal domain. This CD includes various bacterial integrases, including the predicted integrase of the deletion-prone region of plasmid pAE1 of Alcaligenes eutrophus...; Region: INT_pAE1; cd01188 266835014103 Int/Topo IB signature motif; other site 266835014104 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 266835014105 active site 266835014106 Int/Topo IB signature motif; other site 266835014107 DNA binding site [nucleotide binding] 266835014108 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 266835014109 IstB-like ATP binding N-terminal; Region: IstB_IS21_ATP; pfam08483 266835014110 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266835014111 Walker A motif; other site 266835014112 ATP binding site [chemical binding]; other site 266835014113 Walker B motif; other site 266835014114 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 266835014115 Winged helix-turn helix; Region: HTH_29; pfam13551 266835014116 Helix-turn-helix domain; Region: HTH_28; pfam13518 266835014117 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 266835014118 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 266835014119 catalytic residues [active] 266835014120 catalytic nucleophile [active] 266835014121 Recombinase; Region: Recombinase; pfam07508 266835014122 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 266835014123 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 266835014124 DNA binding residues [nucleotide binding] 266835014125 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 266835014126 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 266835014127 Transposase; Region: DEDD_Tnp_IS110; pfam01548 266835014128 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 266835014129 Helix-turn-helix domain; Region: HTH_28; pfam13518 266835014130 Winged helix-turn helix; Region: HTH_29; pfam13551 266835014131 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 266835014132 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 266835014133 Uncharacterized conserved protein [Function unknown]; Region: COG5476 266835014134 MlrC C-terminus; Region: MlrC_C; pfam07171 266835014135 Uncharacterized conserved protein [Function unknown]; Region: COG5476 266835014136 Protein of unknown function (DUF1485); Region: DUF1485; pfam07364 266835014137 Biotin carboxylase [Lipid metabolism]; Region: AccC; COG0439 266835014138 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 266835014139 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 266835014140 Transposase; Region: DEDD_Tnp_IS110; pfam01548 266835014141 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 266835014142 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 266835014143 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 266835014144 Transposase; Region: DEDD_Tnp_IS110; pfam01548 266835014145 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 266835014146 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 266835014147 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 266835014148 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 266835014149 Transposase; Region: DEDD_Tnp_IS110; pfam01548 266835014150 Transposase; Region: DEDD_Tnp_IS110; pfam01548 266835014151 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 266835014152 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 266835014153 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 266835014154 active site 266835014155 enoyl-CoA hydratase; Provisional; Region: PRK08252 266835014156 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266835014157 substrate binding site [chemical binding]; other site 266835014158 oxyanion hole (OAH) forming residues; other site 266835014159 trimer interface [polypeptide binding]; other site 266835014160 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 266835014161 FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659 266835014162 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 266835014163 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 266835014164 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 266835014165 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 266835014166 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266835014167 Walker A/P-loop; other site 266835014168 ATP binding site [chemical binding]; other site 266835014169 Q-loop/lid; other site 266835014170 ABC transporter signature motif; other site 266835014171 Walker B; other site 266835014172 D-loop; other site 266835014173 H-loop/switch region; other site 266835014174 TOBE domain; Region: TOBE_2; pfam08402 266835014175 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835014176 dimer interface [polypeptide binding]; other site 266835014177 conserved gate region; other site 266835014178 putative PBP binding loops; other site 266835014179 ABC-ATPase subunit interface; other site 266835014180 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 266835014181 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835014182 dimer interface [polypeptide binding]; other site 266835014183 conserved gate region; other site 266835014184 putative PBP binding loops; other site 266835014185 ABC-ATPase subunit interface; other site 266835014186 putative amidase; Provisional; Region: PRK06169 266835014187 Amidase; Region: Amidase; pfam01425 266835014188 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 266835014189 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 266835014190 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 266835014191 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835014192 dimer interface [polypeptide binding]; other site 266835014193 conserved gate region; other site 266835014194 putative PBP binding loops; other site 266835014195 ABC-ATPase subunit interface; other site 266835014196 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 266835014197 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835014198 dimer interface [polypeptide binding]; other site 266835014199 conserved gate region; other site 266835014200 putative PBP binding loops; other site 266835014201 ABC-ATPase subunit interface; other site 266835014202 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 266835014203 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266835014204 Walker A/P-loop; other site 266835014205 ATP binding site [chemical binding]; other site 266835014206 Q-loop/lid; other site 266835014207 ABC transporter signature motif; other site 266835014208 Walker B; other site 266835014209 D-loop; other site 266835014210 H-loop/switch region; other site 266835014211 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 266835014212 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 266835014213 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266835014214 Walker A/P-loop; other site 266835014215 ATP binding site [chemical binding]; other site 266835014216 Q-loop/lid; other site 266835014217 ABC transporter signature motif; other site 266835014218 Walker B; other site 266835014219 D-loop; other site 266835014220 H-loop/switch region; other site 266835014221 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 266835014222 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 266835014223 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 266835014224 putative transposase OrfB; Reviewed; Region: PHA02517 266835014225 HTH-like domain; Region: HTH_21; pfam13276 266835014226 Integrase core domain; Region: rve; pfam00665 266835014227 Integrase core domain; Region: rve_3; pfam13683 266835014228 Transposase; Region: HTH_Tnp_1; pfam01527 266835014229 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 266835014230 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266835014231 Walker A motif; other site 266835014232 ATP binding site [chemical binding]; other site 266835014233 Walker B motif; other site 266835014234 Predicted deacylase [General function prediction only]; Region: COG3608 266835014235 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_2; cd06252 266835014236 putative active site [active] 266835014237 Zn binding site [ion binding]; other site 266835014238 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 266835014239 Zn binding site [ion binding]; other site 266835014240 Methylaspartate ammonia-lyase [Amino acid transport and metabolism]; Region: Mal; COG3799 266835014241 Methylaspartate ammonia lyase (3-methylaspartase, MAL) is a homodimeric enzyme, catalyzing the magnesium-dependent reversible alpha,beta-elimination of ammonia from L-threo-(2S,3S)-3-methylaspartic acid to mesaconic acid. This reaction is part of the...; Region: MAL; cd03314 266835014242 dimer interface [polypeptide binding]; other site 266835014243 active site 266835014244 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 266835014245 CoA-transferase family III; Region: CoA_transf_3; pfam02515 266835014246 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266835014247 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266835014248 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 266835014249 putative dimerization interface [polypeptide binding]; other site 266835014250 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 266835014251 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 266835014252 tetramerization interface [polypeptide binding]; other site 266835014253 NAD(P) binding site [chemical binding]; other site 266835014254 catalytic residues [active] 266835014255 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 266835014256 Fumarase C-terminus; Region: Fumerase_C; pfam05683 266835014257 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 266835014258 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266835014259 putative DNA binding site [nucleotide binding]; other site 266835014260 putative Zn2+ binding site [ion binding]; other site 266835014261 AsnC family; Region: AsnC_trans_reg; pfam01037 266835014262 hypothetical protein; Provisional; Region: PRK07482 266835014263 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 266835014264 inhibitor-cofactor binding pocket; inhibition site 266835014265 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266835014266 catalytic residue [active] 266835014267 transcriptional regulator TraR; Provisional; Region: PRK13870 266835014268 Autoinducer binding domain; Region: Autoind_bind; pfam03472 266835014269 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266835014270 DNA binding residues [nucleotide binding] 266835014271 dimerization interface [polypeptide binding]; other site 266835014272 N-acyl-L-homoserine lactone synthetase [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: LasI; COG3916 266835014273 Uncharacterized conserved protein [Function unknown]; Region: COG5419 266835014274 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266835014275 non-specific DNA binding site [nucleotide binding]; other site 266835014276 salt bridge; other site 266835014277 sequence-specific DNA binding site [nucleotide binding]; other site 266835014278 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266835014279 sequence-specific DNA binding site [nucleotide binding]; other site 266835014280 salt bridge; other site 266835014281 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 266835014282 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 266835014283 Transposase; Region: DEDD_Tnp_IS110; pfam01548 266835014284 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 266835014285 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 266835014286 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 266835014287 dimer interface [polypeptide binding]; other site 266835014288 active site 266835014289 glycine-pyridoxal phosphate binding site [chemical binding]; other site 266835014290 folate binding site [chemical binding]; other site 266835014291 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 266835014292 S-adenosylmethionine synthetase; Validated; Region: PRK05250 266835014293 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 266835014294 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 266835014295 Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168 266835014296 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 266835014297 substrate binding site [chemical binding]; other site 266835014298 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 266835014299 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 266835014300 ATP binding site [chemical binding]; other site 266835014301 substrate binding site [chemical binding]; other site 266835014302 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 266835014303 DNA-binding site [nucleotide binding]; DNA binding site 266835014304 RNA-binding motif; other site 266835014305 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 266835014306 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 266835014307 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 266835014308 THF binding site; other site 266835014309 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 266835014310 substrate binding site [chemical binding]; other site 266835014311 THF binding site; other site 266835014312 zinc-binding site [ion binding]; other site 266835014313 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 266835014314 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 266835014315 Cytochrome P450; Region: p450; cl12078 266835014316 Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047 266835014317 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 266835014318 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 266835014319 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 266835014320 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 266835014321 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 266835014322 tetramer interface [polypeptide binding]; other site 266835014323 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266835014324 catalytic residue [active] 266835014325 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 266835014326 Coenzyme A binding pocket [chemical binding]; other site 266835014327 Outer membrane protease [Cell envelope biogenesis, outer membrane]; Region: OmpT; COG4571 266835014328 Domain of unknown function (DUF955); Region: DUF955; cl01076 266835014329 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266835014330 salt bridge; other site 266835014331 non-specific DNA binding site [nucleotide binding]; other site 266835014332 sequence-specific DNA binding site [nucleotide binding]; other site 266835014333 Bacterial multiubiquitin; Region: Bac_multiUb; pfam14452 266835014334 Bacterial multiubiquitin; Region: Bac_multiUb; pfam14452 266835014335 Bacterial multiubiquitin; Region: Bac_multiUb; pfam14452 266835014336 hypothetical protein; Provisional; Region: PRK06153 266835014337 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 266835014338 ATP binding site [chemical binding]; other site 266835014339 substrate interface [chemical binding]; other site 266835014340 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 266835014341 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 266835014342 Transposase domain (DUF772); Region: DUF772; pfam05598 266835014343 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 266835014344 DDE superfamily endonuclease; Region: DDE_3; pfam13358 266835014345 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 266835014346 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 266835014347 Transposase; Region: HTH_Tnp_1; pfam01527 266835014348 putative transposase OrfB; Reviewed; Region: PHA02517 266835014349 HTH-like domain; Region: HTH_21; pfam13276 266835014350 Integrase core domain; Region: rve; pfam00665 266835014351 Integrase core domain; Region: rve_3; pfam13683 266835014352 Transposase, Mutator family; Region: Transposase_mut; pfam00872 266835014353 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 266835014354 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 266835014355 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 266835014356 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 266835014357 Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227 266835014358 Domain of unknown function (DUF1738); Region: DUF1738; pfam08401 266835014359 Protein of unknown function (DUF2958); Region: DUF2958; pfam11171 266835014360 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 266835014361 ParB-like nuclease domain; Region: ParB; smart00470 266835014362 hypothetical protein; Provisional; Region: PRK09126 266835014363 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 266835014364 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266835014365 S-adenosylmethionine binding site [chemical binding]; other site 266835014366 Nodulation protein A (NodA); Region: NodA; pfam02474 266835014367 chitooligosaccharide synthase NodC; Region: nodulat_NodC; TIGR04242 266835014368 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 266835014369 DXD motif; other site 266835014370 nodulation factor exporter subunit NodI; Provisional; Region: PRK13536 266835014371 ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263 266835014372 Walker A/P-loop; other site 266835014373 ATP binding site [chemical binding]; other site 266835014374 Q-loop/lid; other site 266835014375 ABC transporter signature motif; other site 266835014376 Walker B; other site 266835014377 D-loop; other site 266835014378 H-loop/switch region; other site 266835014379 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 266835014380 ABC-2 type transporter; Region: ABC2_membrane; cl17235 266835014381 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 266835014382 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 266835014383 Nodulation protein Z (NodZ); Region: NodZ; pfam05830 266835014384 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 266835014385 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 266835014386 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266835014387 DNA-binding site [nucleotide binding]; DNA binding site 266835014388 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 266835014389 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266835014390 homodimer interface [polypeptide binding]; other site 266835014391 catalytic residue [active] 266835014392 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 266835014393 Putative catalytic domain of rhizobial NodB chitooligosaccharide N-deacetylase and its bacterial homologs; Region: CE4_NodB; cd10943 266835014394 NodB motif; other site 266835014395 putative active site [active] 266835014396 putative catalytic site [active] 266835014397 putative Zn binding site [ion binding]; other site 266835014398 Transcriptional regulator [Transcription]; Region: PaiB; COG2808 266835014399 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 266835014400 Predicted sugar epimerase [Carbohydrate transport and metabolism]; Region: COG4130 266835014401 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266835014402 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266835014403 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266835014404 dimerization interface [polypeptide binding]; other site 266835014405 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 266835014406 Acyltransferase family; Region: Acyl_transf_3; pfam01757 266835014407 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266835014408 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266835014409 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266835014410 dimerization interface [polypeptide binding]; other site 266835014411 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 266835014412 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266835014413 putative substrate translocation pore; other site 266835014414 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 266835014415 salt bridge; other site 266835014416 Uncharacterized conserved protein [Function unknown]; Region: COG5489 266835014417 Helix-turn-helix domain; Region: HTH_17; pfam12728 266835014418 Signal peptidase, peptidase S26; Region: Peptidase_S26; pfam10502 266835014419 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 266835014420 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 266835014421 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 266835014422 N-acetyl-D-glucosamine binding site [chemical binding]; other site 266835014423 catalytic residue [active] 266835014424 Transposase; Region: DEDD_Tnp_IS110; pfam01548 266835014425 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 266835014426 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 266835014427 Type IV secretory pathway, VirD2 components (relaxase) [Intracellular trafficking and secretion]; Region: VirD2; COG3843 266835014428 Protein of unknown function (DUF3363); Region: DUF3363; pfam11843 266835014429 Prokaryotic E2 family C; Region: Prok-E2_C; pfam14459 266835014430 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 [Coenzyme metabolism]; Region: ThiF; COG0476 266835014431 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 266835014432 ATP binding site [chemical binding]; other site 266835014433 substrate interface [chemical binding]; other site 266835014434 Prokaryotic homologs of the JAB domain; Region: Prok-JAB; pfam14464 266835014435 Predicted metal binding domain; Region: Metal_CEHH; pfam14455 266835014436 Protein of Unknown function (DUF2604); Region: DUF2604; pfam10790 266835014437 Protein of unknown function (DUF1403); Region: DUF1403; pfam07183 266835014438 Chromosome segregation and condensation protein B [DNA replication, recombination and repair]; Region: scpB; COG1386 266835014439 Domain of unknown function (DUF4365); Region: DUF4365; pfam14280 266835014440 Piwi_piwi-like_ProArk: PIWI domain, Piwi-like subfamily found in Archaea and Bacteria. RNA silencing refers to a group of related gene-silencing mechanisms mediated by short RNA molecules, including siRNAs, miRNAs, and heterochromatin-related guide RNAs; Region: Piwi_piwi-like_ProArk; cd04659 266835014441 5' RNA guide strand anchoring site; other site 266835014442 active site 266835014443 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 266835014444 Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410 266835014445 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 266835014446 substrate binding pocket [chemical binding]; other site 266835014447 dimer interface [polypeptide binding]; other site 266835014448 inhibitor binding site; inhibition site 266835014449 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 266835014450 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 266835014451 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 266835014452 histidine decarboxylase; Provisional; Region: PRK02769 266835014453 tyrosine decarboxylase MnfA; Region: tyr_de_CO2_Arch; TIGR03812 266835014454 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 266835014455 catalytic residue [active] 266835014456 glutamine synthetase, type III; Region: gln_synth_III; TIGR03105 266835014457 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 266835014458 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 266835014459 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 266835014460 active site 266835014461 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 266835014462 dimer interface [polypeptide binding]; other site 266835014463 substrate binding site [chemical binding]; other site 266835014464 catalytic residues [active] 266835014465 Integrase core domain; Region: rve; pfam00665 266835014466 MmgE/PrpD family; Region: MmgE_PrpD; pfam03972 266835014467 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 266835014468 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 266835014469 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 266835014470 active site 266835014471 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 266835014472 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 266835014473 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 266835014474 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 266835014475 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 266835014476 catalytic residues [active] 266835014477 catalytic nucleophile [active] 266835014478 Recombinase; Region: Recombinase; pfam07508 266835014479 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 266835014480 Recombinase; Region: Recombinase; pfam07508 266835014481 transposase; Validated; Region: PRK08181 266835014482 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266835014483 Walker A motif; other site 266835014484 ATP binding site [chemical binding]; other site 266835014485 Walker B motif; other site 266835014486 Integrase core domain; Region: rve; pfam00665 266835014487 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 266835014488 Transposase domain (DUF772); Region: DUF772; pfam05598 266835014489 Methyltransferase domain; Region: Methyltransf_31; pfam13847 266835014490 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266835014491 S-adenosylmethionine binding site [chemical binding]; other site 266835014492 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 266835014493 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 266835014494 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 266835014495 INT_SG5, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 5, N- and C-terminal domains. The CD contains mainly predicted bacterial integrase/recombinases; Region: INT_SG5; cd01190 266835014496 Int/Topo IB signature motif; other site 266835014497 INT_SG4, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 4, N- and C-terminal domains. The CD contains mainly predicted bacterial integrase/recombinases for which not much biochemical characterization is available; Region: INT_SG4; cd01187 266835014498 Int/Topo IB signature motif; other site 266835014499 pAE1 and related integrases, DNA breaking-rejoining enzymes, integrase/recombinases, C-terminal domain. This CD includes various bacterial integrases, including the predicted integrase of the deletion-prone region of plasmid pAE1 of Alcaligenes eutrophus...; Region: INT_pAE1; cd01188 266835014500 Int/Topo IB signature motif; other site 266835014501 transposase; Validated; Region: PRK08181 266835014502 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266835014503 Walker A motif; other site 266835014504 ATP binding site [chemical binding]; other site 266835014505 Walker B motif; other site 266835014506 Integrase core domain; Region: rve; pfam00665 266835014507 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 266835014508 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 266835014509 conserved cys residue [active] 266835014510 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266835014511 Sarcosine oxidase gamma subunit [Amino acid transport and metabolism]; Region: COG4583 266835014512 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 266835014513 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 266835014514 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 266835014515 Sarcosine oxidase delta subunit [Amino acid transport and metabolism]; Region: SoxD; COG4311 266835014516 sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373 266835014517 hydroxyglutarate oxidase; Provisional; Region: PRK11728 266835014518 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 266835014519 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 266835014520 conserved cys residue [active] 266835014521 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266835014522 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 266835014523 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 266835014524 Transposase; Region: HTH_Tnp_1; pfam01527 266835014525 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 266835014526 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 266835014527 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 266835014528 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 266835014529 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 266835014530 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 266835014531 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 266835014532 Domain of unknown function (DUF4084); Region: DUF4084; pfam13321 266835014533 Cu2+-containing amine oxidase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TynA; COG3733 266835014534 Copper amine oxidase, N2 domain; Region: Cu_amine_oxidN2; pfam02727 266835014535 Copper amine oxidase, N3 domain; Region: Cu_amine_oxidN3; pfam02728 266835014536 Copper amine oxidase, enzyme domain; Region: Cu_amine_oxid; pfam01179 266835014537 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 266835014538 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 266835014539 catalytic triad [active] 266835014540 MmgE/PrpD family; Region: MmgE_PrpD; pfam03972 266835014541 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 266835014542 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 266835014543 catalytic triad [active] 266835014544 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 266835014545 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 266835014546 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 266835014547 active site 266835014548 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835014549 dimer interface [polypeptide binding]; other site 266835014550 conserved gate region; other site 266835014551 putative PBP binding loops; other site 266835014552 ABC-ATPase subunit interface; other site 266835014553 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 266835014554 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835014555 dimer interface [polypeptide binding]; other site 266835014556 conserved gate region; other site 266835014557 putative PBP binding loops; other site 266835014558 ABC-ATPase subunit interface; other site 266835014559 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 266835014560 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 266835014561 Walker A/P-loop; other site 266835014562 ATP binding site [chemical binding]; other site 266835014563 Q-loop/lid; other site 266835014564 ABC transporter signature motif; other site 266835014565 Walker B; other site 266835014566 D-loop; other site 266835014567 H-loop/switch region; other site 266835014568 TOBE domain; Region: TOBE_2; pfam08402 266835014569 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 266835014570 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 266835014571 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 266835014572 Transcriptional regulator [Transcription]; Region: IclR; COG1414 266835014573 Bacterial transcriptional regulator; Region: IclR; pfam01614 266835014574 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 266835014575 DNA-binding site [nucleotide binding]; DNA binding site 266835014576 RNA-binding motif; other site 266835014577 Predicted transcriptional regulator [Transcription]; Region: COG4957 266835014578 Chromosome segregation and condensation protein B [DNA replication, recombination and repair]; Region: scpB; COG1386 266835014579 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 266835014580 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266835014581 non-specific DNA binding site [nucleotide binding]; other site 266835014582 salt bridge; other site 266835014583 sequence-specific DNA binding site [nucleotide binding]; other site 266835014584 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 266835014585 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 266835014586 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 266835014587 AAA domain; Region: AAA_26; pfam13500 266835014588 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK06106 266835014589 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 266835014590 dimerization interface [polypeptide binding]; other site 266835014591 active site 266835014592 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 266835014593 Winged helix-turn helix; Region: HTH_29; pfam13551 266835014594 Helix-turn-helix domain; Region: HTH_28; pfam13518 266835014595 Integrase core domain; Region: rve; pfam00665 266835014596 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 266835014597 Bacterial TniB protein; Region: TniB; pfam05621 266835014598 AAA domain; Region: AAA_22; pfam13401 266835014599 TniQ; Region: TniQ; pfam06527 266835014600 Transposase, Mutator family; Region: Transposase_mut; pfam00872 266835014601 MULE transposase domain; Region: MULE; pfam10551 266835014602 Integrase core domain; Region: rve; pfam00665 266835014603 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 266835014604 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 266835014605 acyl-activating enzyme (AAE) consensus motif; other site 266835014606 AMP binding site [chemical binding]; other site 266835014607 Aminoglycoside N3'-acetyltransferase [Defense mechanisms]; Region: COG2746 266835014608 Aspartyl/Asparaginyl beta-hydroxylase; Region: Asp_Arg_Hydrox; cl17820 266835014609 L-proline 3-hydroxylase, C-terminal; Region: Pro_3_hydrox_C; pfam05373 266835014610 Transmembrane secretion effector; Region: MFS_3; pfam05977 266835014611 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266835014612 putative substrate translocation pore; other site 266835014613 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 266835014614 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 266835014615 hydroxyglutarate oxidase; Provisional; Region: PRK11728 266835014616 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 266835014617 Membrane dipeptidase (Peptidase family M19); Region: Peptidase_M19; pfam01244 266835014618 active site 266835014619 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 266835014620 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266835014621 Walker A/P-loop; other site 266835014622 ATP binding site [chemical binding]; other site 266835014623 Q-loop/lid; other site 266835014624 ABC transporter signature motif; other site 266835014625 Walker B; other site 266835014626 D-loop; other site 266835014627 H-loop/switch region; other site 266835014628 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 266835014629 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266835014630 Walker A/P-loop; other site 266835014631 ATP binding site [chemical binding]; other site 266835014632 Q-loop/lid; other site 266835014633 ABC transporter signature motif; other site 266835014634 Walker B; other site 266835014635 D-loop; other site 266835014636 H-loop/switch region; other site 266835014637 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 266835014638 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 266835014639 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_16; cd08502 266835014640 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 266835014641 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835014642 dimer interface [polypeptide binding]; other site 266835014643 conserved gate region; other site 266835014644 putative PBP binding loops; other site 266835014645 ABC-ATPase subunit interface; other site 266835014646 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 266835014647 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835014648 ABC-ATPase subunit interface; other site 266835014649 putative PBP binding loops; other site 266835014650 Transcriptional regulators [Transcription]; Region: GntR; COG1802 266835014651 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266835014652 DNA-binding site [nucleotide binding]; DNA binding site 266835014653 FCD domain; Region: FCD; pfam07729 266835014654 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 266835014655 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 266835014656 inhibitor site; inhibition site 266835014657 active site 266835014658 dimer interface [polypeptide binding]; other site 266835014659 catalytic residue [active] 266835014660 Uncharacterized conserved protein [Function unknown]; Region: COG5476 266835014661 Protein of unknown function (DUF1485); Region: DUF1485; pfam07364 266835014662 MlrC C-terminus; Region: MlrC_C; pfam07171 266835014663 Biotin carboxylase [Lipid metabolism]; Region: AccC; COG0439 266835014664 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 266835014665 Glutamate 5-kinase [Amino acid transport and metabolism]; Region: ProB; COG0263 266835014666 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 266835014667 nucleotide binding site [chemical binding]; other site 266835014668 homotetrameric interface [polypeptide binding]; other site 266835014669 putative phosphate binding site [ion binding]; other site 266835014670 putative allosteric binding site; other site 266835014671 Transcriptional regulators [Transcription]; Region: GntR; COG1802 266835014672 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266835014673 DNA-binding site [nucleotide binding]; DNA binding site 266835014674 FCD domain; Region: FCD; pfam07729 266835014675 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 266835014676 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 266835014677 Integrase core domain; Region: rve; pfam00665 266835014678 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 266835014679 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4487 266835014680 Uncharacterized protein conserved in bacteria (DUF2130); Region: DUF2130; pfam09903 266835014681 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4487 266835014682 Phage-related replication protein [General function prediction only]; Region: COG4195 266835014683 S1/P1 nucleases and related enzymes; Region: S1-P1_nuclease; cd11010 266835014684 active site 266835014685 Zn binding site [ion binding]; other site 266835014686 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 266835014687 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 266835014688 putative active site [active] 266835014689 catalytic site [active] 266835014690 Putative catalytic domain, repeat 2, of uncharacterized hypothetical proteins similar to Nuc, an endonuclease from Salmonella typhimurium; Region: PLDc_Nuc_like_unchar1_2; cd09173 266835014691 putative active site [active] 266835014692 catalytic site [active] 266835014693 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 266835014694 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 266835014695 Transposase; Region: DDE_Tnp_ISL3; pfam01610 266835014696 Transposase and inactivated derivatives, TnpA family [DNA replication, recombination, and repair]; Region: COG4644 266835014697 Transposase and inactivated derivatives, TnpA family [DNA replication, recombination, and repair]; Region: COG4644 266835014698 Suppression of tumorigenicity 7; Region: ST7; cd11557 266835014699 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266835014700 binding surface 266835014701 TPR motif; other site 266835014702 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 266835014703 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 266835014704 catalytic residues [active] 266835014705 catalytic nucleophile [active] 266835014706 Presynaptic Site I dimer interface [polypeptide binding]; other site 266835014707 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 266835014708 Synaptic Flat tetramer interface [polypeptide binding]; other site 266835014709 Synaptic Site I dimer interface [polypeptide binding]; other site 266835014710 DNA binding site [nucleotide binding] 266835014711 hypothetical protein; Validated; Region: PRK09169 266835014712 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 266835014713 ADP binding site [chemical binding]; other site 266835014714 magnesium binding site [ion binding]; other site 266835014715 putative shikimate binding site; other site 266835014716 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 266835014717 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266835014718 active site 266835014719 phosphorylation site [posttranslational modification] 266835014720 intermolecular recognition site; other site 266835014721 dimerization interface [polypeptide binding]; other site 266835014722 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266835014723 DNA binding site [nucleotide binding] 266835014724 Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964 266835014725 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 266835014726 BON domain; Region: BON; pfam04972 266835014727 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 266835014728 Type IV pili component [Cell motility and secretion]; Region: COG5461 266835014729 Pilus biogenesis CpaD protein (pilus_cpaD); Region: Pilus_CpaD; pfam09476 266835014730 NolX protein; Region: NolX; pfam05819 266835014731 Type II secretory pathway, component PulD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulD; COG1450 266835014732 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 266835014733 Type III secretory pathway, lipoprotein EscJ [Intracellular trafficking and secretion]; Region: EscJ; COG4669 266835014734 Nodulation protein NolV; Region: NolV; pfam06635 266835014735 Flagellar biosynthesis/type III secretory pathway ATPase [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliI; COG1157 266835014736 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 266835014737 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 266835014738 Walker A motif/ATP binding site; other site 266835014739 Walker B motif; other site 266835014740 type III secretion system apparatus protein YscQ/HrcQ; Region: SpaO_YscQ; TIGR02551 266835014741 Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886 266835014742 Type III secretory pathway, component EscR [Intracellular trafficking and secretion]; Region: EscR; COG4790 266835014743 Type III secretory pathway, component EscS [Intracellular trafficking and secretion]; Region: EscS; COG4794 266835014744 type III secretion protein SpaR/YscT/HrcT; Region: fliR_like_III; TIGR01401 266835014745 Type III secretory pathway, component EscU [Intracellular trafficking and secretion]; Region: EscU; COG4792 266835014746 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 266835014747 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 266835014748 Type III secretory pathway, component EscV [Intracellular trafficking and secretion]; Region: EscV; COG4789 266835014749 FHIPEP family; Region: FHIPEP; pfam00771 266835014750 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 266835014751 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266835014752 binding surface 266835014753 TPR motif; other site 266835014754 Tetratricopeptide repeat; Region: TPR_16; pfam13432 266835014755 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 266835014756 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 266835014757 Integrase core domain; Region: rve; pfam00665 266835014758 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 266835014759 DDE superfamily endonuclease; Region: DDE_5; cl17874 266835014760 FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659 266835014761 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 266835014762 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 266835014763 Integrase core domain; Region: rve; pfam00665 266835014764 hypothetical protein; Validated; Region: PRK09169 266835014765 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 266835014766 ADP binding site [chemical binding]; other site 266835014767 magnesium binding site [ion binding]; other site 266835014768 putative shikimate binding site; other site 266835014769 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 266835014770 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 266835014771 Integrase core domain; Region: rve; pfam00665 266835014772 Transposase and inactivated derivatives, TnpA family [DNA replication, recombination, and repair]; Region: COG4644 266835014773 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 266835014774 Cytochrome P450; Region: p450; cl12078 266835014775 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 266835014776 Cytochrome P450; Region: p450; cl12078 266835014777 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 266835014778 classical (c) SDR, subgroup 12; Region: SDR_c12; cd08944 266835014779 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 266835014780 homodimer interface [polypeptide binding]; other site 266835014781 putative NAD(P) binding site [chemical binding]; other site 266835014782 active site 266835014783 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 266835014784 Cytochrome P450; Region: p450; cl12078 266835014785 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 266835014786 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 266835014787 substrate binding pocket [chemical binding]; other site 266835014788 chain length determination region; other site 266835014789 substrate-Mg2+ binding site; other site 266835014790 catalytic residues [active] 266835014791 aspartate-rich region 1; other site 266835014792 active site lid residues [active] 266835014793 aspartate-rich region 2; other site 266835014794 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 266835014795 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 266835014796 substrate binding pocket [chemical binding]; other site 266835014797 substrate-Mg2+ binding site; other site 266835014798 aspartate-rich region 1; other site 266835014799 aspartate-rich region 2; other site 266835014800 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 266835014801 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 266835014802 homotetramer interface [polypeptide binding]; other site 266835014803 FMN binding site [chemical binding]; other site 266835014804 homodimer contacts [polypeptide binding]; other site 266835014805 putative active site [active] 266835014806 putative substrate binding site [chemical binding]; other site 266835014807 Transmembrane secretion effector; Region: MFS_3; pfam05977 266835014808 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266835014809 putative substrate translocation pore; other site 266835014810 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 266835014811 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 266835014812 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 266835014813 inhibitor site; inhibition site 266835014814 active site 266835014815 dimer interface [polypeptide binding]; other site 266835014816 catalytic residue [active] 266835014817 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 266835014818 Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382 266835014819 B3/4 domain; Region: B3_4; pfam03483 266835014820 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 266835014821 DDE superfamily endonuclease; Region: DDE_3; pfam13358 266835014822 DDE superfamily endonuclease; Region: DDE_3; pfam13358 266835014823 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 266835014824 Paired Box domain; Region: PAX; cd00131 266835014825 DNA binding site [nucleotide binding] 266835014826 Homeodomain-like domain; Region: HTH_32; pfam13565 266835014827 Carbonic anhydrase [Inorganic ion transport and metabolism]; Region: Cah; COG3338 266835014828 Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124 266835014829 active site 266835014830 zinc binding site [ion binding]; other site 266835014831 N-acyl-L-homoserine lactone synthetase [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: LasI; COG3916 266835014832 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 266835014833 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 266835014834 glutaminase active site [active] 266835014835 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 266835014836 dimer interface [polypeptide binding]; other site 266835014837 active site 266835014838 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 266835014839 dimer interface [polypeptide binding]; other site 266835014840 active site 266835014841 Porin subfamily; Region: Porin_2; pfam02530 266835014842 coproporphyrinogen III oxidase; Provisional; Region: PRK13347 266835014843 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 266835014844 FeS/SAM binding site; other site 266835014845 HemN C-terminal domain; Region: HemN_C; pfam06969 266835014846 Predicted periplasmic or secreted protein [General function prediction only]; Region: COG3443 266835014847 conjugal transfer coupling protein TraG; Provisional; Region: PRK13876 266835014848 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 266835014849 Walker A motif; other site 266835014850 ATP binding site [chemical binding]; other site 266835014851 Walker B motif; other site 266835014852 P-type conjugative transfer ATPase TrbB; Region: TrbB_P; TIGR02782 266835014853 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 266835014854 ATP binding site [chemical binding]; other site 266835014855 Walker A motif; other site 266835014856 hexamer interface [polypeptide binding]; other site 266835014857 Walker B motif; other site 266835014858 Type IV secretory pathway, VirB2 components (pilins) [Intracellular trafficking and secretion]; Region: VirB2; COG3838 266835014859 conjugal transfer ATPase TrbE; Provisional; Region: PRK13873 266835014860 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 266835014861 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266835014862 Walker A/P-loop; other site 266835014863 ATP binding site [chemical binding]; other site 266835014864 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 266835014865 Conjugal transfer/entry exclusion protein [Intracellular trafficking and secretion]; Region: COG5314 266835014866 conjugal transfer protein TrbJ; Provisional; Region: PRK13874 266835014867 conjugal transfer protein TrbL; Provisional; Region: PRK13875 266835014868 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; pfam04610 266835014869 conjugal transfer protein TrbF; Provisional; Region: PRK13872 266835014870 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 266835014871 VirB7 interaction site; other site 266835014872 Type IV secretory pathway, VirB10 components [Intracellular trafficking and secretion]; Region: VirB10; COG2948 266835014873 Uncharacterized conserved small protein [Function unknown]; Region: COG5639 266835014874 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 266835014875 HemN C-terminal domain; Region: HemN_C; pfam06969 266835014876 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 266835014877 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 266835014878 ligand binding site [chemical binding]; other site 266835014879 flexible hinge region; other site 266835014880 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 266835014881 putative switch regulator; other site 266835014882 non-specific DNA interactions [nucleotide binding]; other site 266835014883 DNA binding site [nucleotide binding] 266835014884 sequence specific DNA binding site [nucleotide binding]; other site 266835014885 putative cAMP binding site [chemical binding]; other site 266835014886 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 266835014887 Cytochrome cbb3 oxidase subunit I. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661 266835014888 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 266835014889 Low-spin heme binding site [chemical binding]; other site 266835014890 Putative water exit pathway; other site 266835014891 Binuclear center (active site) [active] 266835014892 Putative proton exit pathway; other site 266835014893 Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993 266835014894 Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; pfam02433 266835014895 Cytochrome cbb oxidase CcoQ. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of O2...; Region: cbb3_Oxidase_CcoQ; cd01324 266835014896 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 266835014897 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 266835014898 Cytochrome c; Region: Cytochrom_C; pfam00034 266835014899 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 266835014900 4Fe-4S binding domain; Region: Fer4_5; pfam12801 266835014901 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 266835014902 Predicted integral membrane protein linked to a cation pump [Inorganic ion transport and metabolism]; Region: COG5456 266835014903 FixH; Region: FixH; pfam05751 266835014904 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 266835014905 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 266835014906 metal-binding site [ion binding] 266835014907 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 266835014908 Uncharacterized protein, possibly involved in nitrogen fixation [Inorganic ion transport and metabolism]; Region: FixS; COG3197 266835014909 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 266835014910 Fic family protein [Function unknown]; Region: COG3177 266835014911 Fic/DOC family; Region: Fic; pfam02661 266835014912 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 266835014913 Ligand Binding Site [chemical binding]; other site 266835014914 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 266835014915 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 266835014916 ATP binding site [chemical binding]; other site 266835014917 substrate binding site [chemical binding]; other site 266835014918 Nucleoside 2-deoxyribosyltransferase [Nucleotide transport and metabolism]; Region: COG3613 266835014919 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 266835014920 helix-hairpin-helix signature motif; other site 266835014921 substrate binding pocket [chemical binding]; other site 266835014922 active site 266835014923 deoxyguanosinetriphosphate triphosphohydrolase, putative; Region: dGTP_triPase; TIGR01353 266835014924 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 266835014925 Zn2+ binding site [ion binding]; other site 266835014926 Mg2+ binding site [ion binding]; other site 266835014927 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 266835014928 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 266835014929 Putative transposase; Region: Y2_Tnp; pfam04986 266835014930 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 266835014931 IntI (E2) integrases, site-specific tyrosine recombinases, DNA breaking-rejoining enzymes, N- and C-terminal domains. This CD includes integrases which are components of multiresistant integrons and mediate recombination between a proximal attI site and...; Region: INT_IntI; cd01193 266835014932 Int/Topo IB signature motif; other site 266835014933 integrase; Provisional; Region: PRK09692 266835014934 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 266835014935 active site 266835014936 Int/Topo IB signature motif; other site 266835014937 Cupin domain; Region: Cupin_2; pfam07883 266835014938 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 266835014939 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266835014940 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 266835014941 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 266835014942 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835014943 dimer interface [polypeptide binding]; other site 266835014944 conserved gate region; other site 266835014945 putative PBP binding loops; other site 266835014946 ABC-ATPase subunit interface; other site 266835014947 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 266835014948 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 266835014949 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 266835014950 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 266835014951 Walker A/P-loop; other site 266835014952 ATP binding site [chemical binding]; other site 266835014953 Q-loop/lid; other site 266835014954 ABC transporter signature motif; other site 266835014955 Walker B; other site 266835014956 D-loop; other site 266835014957 H-loop/switch region; other site 266835014958 TOBE domain; Region: TOBE; pfam03459 266835014959 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 266835014960 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 266835014961 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 266835014962 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 266835014963 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 266835014964 active site 266835014965 catalytic tetrad [active] 266835014966 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 266835014967 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 266835014968 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266835014969 alpha-galactosidase; Provisional; Region: PRK15076 266835014970 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 266835014971 NAD binding site [chemical binding]; other site 266835014972 sugar binding site [chemical binding]; other site 266835014973 divalent metal binding site [ion binding]; other site 266835014974 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 266835014975 dimer interface [polypeptide binding]; other site 266835014976 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_4; cd08500 266835014977 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 266835014978 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 266835014979 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835014980 dimer interface [polypeptide binding]; other site 266835014981 conserved gate region; other site 266835014982 putative PBP binding loops; other site 266835014983 ABC-ATPase subunit interface; other site 266835014984 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 266835014985 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835014986 dimer interface [polypeptide binding]; other site 266835014987 conserved gate region; other site 266835014988 putative PBP binding loops; other site 266835014989 ABC-ATPase subunit interface; other site 266835014990 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 266835014991 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266835014992 Walker A/P-loop; other site 266835014993 ATP binding site [chemical binding]; other site 266835014994 Q-loop/lid; other site 266835014995 ABC transporter signature motif; other site 266835014996 Walker B; other site 266835014997 D-loop; other site 266835014998 H-loop/switch region; other site 266835014999 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 266835015000 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266835015001 Walker A/P-loop; other site 266835015002 ATP binding site [chemical binding]; other site 266835015003 Q-loop/lid; other site 266835015004 ABC transporter signature motif; other site 266835015005 Walker B; other site 266835015006 D-loop; other site 266835015007 H-loop/switch region; other site 266835015008 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 266835015009 alpha-galactosidase; Provisional; Region: PRK15076 266835015010 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 266835015011 NAD binding site [chemical binding]; other site 266835015012 sugar binding site [chemical binding]; other site 266835015013 divalent metal binding site [ion binding]; other site 266835015014 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 266835015015 dimer interface [polypeptide binding]; other site 266835015016 zinc-binding protein; Provisional; Region: PRK01343 266835015017 Maf-like protein; Region: Maf; pfam02545 266835015018 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 266835015019 active site 266835015020 dimer interface [polypeptide binding]; other site 266835015021 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 266835015022 rRNA binding site [nucleotide binding]; other site 266835015023 predicted 30S ribosome binding site; other site 266835015024 Low molecular weight phosphatase family; Region: LMWPc; cl00105 266835015025 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 266835015026 active site 266835015027 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5328 266835015028 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 266835015029 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 266835015030 NAD binding site [chemical binding]; other site 266835015031 dimerization interface [polypeptide binding]; other site 266835015032 product binding site; other site 266835015033 substrate binding site [chemical binding]; other site 266835015034 zinc binding site [ion binding]; other site 266835015035 catalytic residues [active] 266835015036 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 266835015037 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 266835015038 hinge; other site 266835015039 active site 266835015040 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 266835015041 cyclase homology domain; Region: CHD; cd07302 266835015042 nucleotidyl binding site; other site 266835015043 metal binding site [ion binding]; metal-binding site 266835015044 dimer interface [polypeptide binding]; other site 266835015045 Predicted metal-binding integral membrane protein [Function unknown]; Region: COG5486 266835015046 Predicted metal-binding integral membrane protein (DUF2182); Region: DUF2182; pfam09948 266835015047 Uncharacterized conserved protein [Function unknown]; Region: COG5588 266835015048 Uncharacterized protein related to arylsulfate sulfotransferase involved in siderophore biosynthesis [General function prediction only]; Region: COG4321 266835015049 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 266835015050 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 266835015051 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 266835015052 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 266835015053 TadE-like protein; Region: TadE; pfam07811 266835015054 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 266835015055 TadE-like protein; Region: TadE; pfam07811 266835015056 Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964 266835015057 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 266835015058 BON domain; Region: BON; pfam04972 266835015059 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 266835015060 Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745 266835015061 Flp pilus assembly protein CpaB; Region: pilus_cpaB; TIGR03177 266835015062 Flp pilus assembly protein, pilin Flp [Intracellular trafficking and secretion]; Region: Flp; COG3847 266835015063 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 266835015064 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 266835015065 ATP binding site [chemical binding]; other site 266835015066 Walker A motif; other site 266835015067 hexamer interface [polypeptide binding]; other site 266835015068 Walker B motif; other site 266835015069 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 266835015070 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 266835015071 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 266835015072 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 266835015073 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266835015074 TPR motif; other site 266835015075 binding surface 266835015076 TPR repeat; Region: TPR_11; pfam13414 266835015077 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 266835015078 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 266835015079 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 266835015080 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 266835015081 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 266835015082 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 266835015083 Bacterial protein of unknown function (DUF882); Region: Peptidase_M15_2; pfam05951 266835015084 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 266835015085 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 266835015086 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 266835015087 Predicted homoserine dehydrogenase [Amino acid transport and metabolism]; Region: COG4091 266835015088 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 266835015089 SAF domain of putative dehydrogenases or oxidoreductases; Region: SAF_DH_OX_like; cd11616 266835015090 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 266835015091 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 266835015092 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 266835015093 O-Antigen ligase; Region: Wzy_C; pfam04932 266835015094 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 266835015095 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 266835015096 active site 266835015097 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087 266835015098 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 266835015099 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 266835015100 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 266835015101 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 266835015102 Polysaccharide biosynthesis protein; Region: Polysacc_synt_3; pfam13440 266835015103 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 266835015104 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14188 266835015105 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 266835015106 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 266835015107 homodimer interface [polypeptide binding]; other site 266835015108 NADP binding site [chemical binding]; other site 266835015109 substrate binding site [chemical binding]; other site 266835015110 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 266835015111 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 266835015112 conserved cys residue [active] 266835015113 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266835015114 von Willebrand factor type A domain; Region: VWA_2; pfam13519 266835015115 metal ion-dependent adhesion site (MIDAS); other site 266835015116 phosphogluconate dehydratase; Validated; Region: PRK09054 266835015117 6-phosphogluconate dehydratase; Region: edd; TIGR01196 266835015118 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 266835015119 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 266835015120 putative active site [active] 266835015121 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 266835015122 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 266835015123 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 266835015124 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR), subgroup 3, classical (c) SDR; Region: BKR_3_SDR_c; cd05345 266835015125 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 266835015126 putative NAD(P) binding site [chemical binding]; other site 266835015127 active site 266835015128 Bacterial SH3 domain; Region: SH3_3; pfam08239 266835015129 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 266835015130 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 266835015131 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 266835015132 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 266835015133 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 266835015134 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 266835015135 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 266835015136 motif II; other site 266835015137 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 266835015138 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266835015139 active site 266835015140 phosphorylation site [posttranslational modification] 266835015141 intermolecular recognition site; other site 266835015142 dimerization interface [polypeptide binding]; other site 266835015143 isocitrate lyase; Provisional; Region: PRK15063 266835015144 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 266835015145 tetramer interface [polypeptide binding]; other site 266835015146 active site 266835015147 Mg2+/Mn2+ binding site [ion binding]; other site 266835015148 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 266835015149 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266835015150 non-specific DNA binding site [nucleotide binding]; other site 266835015151 salt bridge; other site 266835015152 sequence-specific DNA binding site [nucleotide binding]; other site 266835015153 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 266835015154 Domain of unknown function (DUF955); Region: DUF955; pfam06114 266835015155 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 266835015156 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 266835015157 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 266835015158 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 266835015159 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 266835015160 Walker A/P-loop; other site 266835015161 ATP binding site [chemical binding]; other site 266835015162 Q-loop/lid; other site 266835015163 ABC transporter signature motif; other site 266835015164 Walker B; other site 266835015165 D-loop; other site 266835015166 H-loop/switch region; other site 266835015167 TOBE domain; Region: TOBE_2; pfam08402 266835015168 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835015169 dimer interface [polypeptide binding]; other site 266835015170 conserved gate region; other site 266835015171 putative PBP binding loops; other site 266835015172 ABC-ATPase subunit interface; other site 266835015173 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 266835015174 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835015175 dimer interface [polypeptide binding]; other site 266835015176 conserved gate region; other site 266835015177 putative PBP binding loops; other site 266835015178 ABC-ATPase subunit interface; other site 266835015179 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 266835015180 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 266835015181 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 266835015182 Acetoacetyl-CoA synthetase (acetoacetate-CoA ligase, AACS); Region: AACS; cd05943 266835015183 acyl-activating enzyme (AAE) consensus motif; other site 266835015184 putative AMP binding site [chemical binding]; other site 266835015185 putative active site [active] 266835015186 putative CoA binding site [chemical binding]; other site 266835015187 PAS domain; Region: PAS_9; pfam13426 266835015188 PAS domain; Region: PAS_9; pfam13426 266835015189 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 266835015190 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266835015191 putative active site [active] 266835015192 heme pocket [chemical binding]; other site 266835015193 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266835015194 dimer interface [polypeptide binding]; other site 266835015195 phosphorylation site [posttranslational modification] 266835015196 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266835015197 ATP binding site [chemical binding]; other site 266835015198 Mg2+ binding site [ion binding]; other site 266835015199 G-X-G motif; other site 266835015200 Uncharacterized conserved protein [Function unknown]; Region: COG5490 266835015201 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 266835015202 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266835015203 DNA binding residues [nucleotide binding] 266835015204 dimerization interface [polypeptide binding]; other site 266835015205 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266835015206 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 266835015207 Walker A motif; other site 266835015208 ATP binding site [chemical binding]; other site 266835015209 Walker B motif; other site 266835015210 arginine finger; other site 266835015211 Protein of unknown function (DUF4255); Region: DUF4255; pfam14065 266835015212 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 266835015213 Phage tail sheath protein FI [General function prediction only]; Region: COG3497 266835015214 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841 266835015215 conserved hypothetical phage tail region protein; Region: TIGR02241 266835015216 Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652 266835015217 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 266835015218 Phage protein D [General function prediction only]; Region: COG3500 266835015219 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501 266835015220 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 266835015221 Uncharacterized conserved protein [Function unknown]; Region: COG4104 266835015222 Phage baseplate assembly protein W [General function prediction only]; Region: COG3628 266835015223 conserved hypothetical protein, phage tail-like region; Region: TIGR02243 266835015224 conserved hypothetical protein, phage tail-like region; Region: TIGR02243 266835015225 phage tail protein domain; Region: tail_TIGR02242 266835015226 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 266835015227 Uncharacterized conserved protein [Function unknown]; Region: COG5620 266835015228 GAD-like domain; Region: GAD-like; pfam08887 266835015229 Domain of unknown function (DUF1851); Region: DUF1851; pfam08906 266835015230 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 266835015231 Universal stress protein UspA and related nucleotide-binding proteins [Signal transduction mechanisms]; Region: UspA; COG0589 266835015232 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 266835015233 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 266835015234 Beta-Casp domain; Region: Beta-Casp; smart01027 266835015235 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 266835015236 putative phosphoketolase; Provisional; Region: PRK05261 266835015237 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 266835015238 TPP-binding site; other site 266835015239 XFP C-terminal domain; Region: XFP_C; pfam09363 266835015240 Acetate kinase [Energy production and conversion]; Region: ackA; COG0282 266835015241 propionate/acetate kinase; Provisional; Region: PRK12379 266835015242 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 266835015243 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 266835015244 Coenzyme A binding pocket [chemical binding]; other site 266835015245 transcriptional regulator FixK; Provisional; Region: fixK; PRK09391 266835015246 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 266835015247 ligand binding site [chemical binding]; other site 266835015248 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 266835015249 putative switch regulator; other site 266835015250 non-specific DNA interactions [nucleotide binding]; other site 266835015251 DNA binding site [nucleotide binding] 266835015252 sequence specific DNA binding site [nucleotide binding]; other site 266835015253 putative cAMP binding site [chemical binding]; other site 266835015254 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 266835015255 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 266835015256 active site 266835015257 metal binding site [ion binding]; metal-binding site 266835015258 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 266835015259 Catalytic domain of Protein Kinases; Region: PKc; cd00180 266835015260 active site 266835015261 ATP binding site [chemical binding]; other site 266835015262 substrate binding site [chemical binding]; other site 266835015263 activation loop (A-loop); other site 266835015264 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 266835015265 Ligand Binding Site [chemical binding]; other site 266835015266 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 266835015267 Uncharacterized copper-binding protein [Inorganic ion transport and metabolism]; Region: COG4454 266835015268 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 266835015269 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 266835015270 Predicted membrane protein [Function unknown]; Region: COG3174 266835015271 Domain of unknown function (DUF4010); Region: DUF4010; pfam13194 266835015272 thioredoxin 2; Provisional; Region: PRK10996 266835015273 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 266835015274 catalytic residues [active] 266835015275 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 266835015276 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 266835015277 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 266835015278 CoA binding domain; Region: CoA_binding_2; pfam13380 266835015279 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 266835015280 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 266835015281 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 266835015282 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 266835015283 Coenzyme A binding pocket [chemical binding]; other site 266835015284 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 266835015285 Predicted kinase [General function prediction only]; Region: COG0645 266835015286 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 266835015287 active site 266835015288 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 266835015289 Ligand Binding Site [chemical binding]; other site 266835015290 Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467 266835015291 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 266835015292 active site 266835015293 Uncharacterized conserved protein [Function unknown]; Region: COG5502 266835015294 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 266835015295 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 266835015296 substrate-cofactor binding pocket; other site 266835015297 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266835015298 catalytic residue [active] 266835015299 response regulator FixJ; Provisional; Region: fixJ; PRK09390 266835015300 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266835015301 active site 266835015302 phosphorylation site [posttranslational modification] 266835015303 intermolecular recognition site; other site 266835015304 dimerization interface [polypeptide binding]; other site 266835015305 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266835015306 DNA binding residues [nucleotide binding] 266835015307 dimerization interface [polypeptide binding]; other site 266835015308 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 266835015309 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 266835015310 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266835015311 putative active site [active] 266835015312 heme pocket [chemical binding]; other site 266835015313 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266835015314 dimer interface [polypeptide binding]; other site 266835015315 phosphorylation site [posttranslational modification] 266835015316 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266835015317 ATP binding site [chemical binding]; other site 266835015318 Mg2+ binding site [ion binding]; other site 266835015319 G-X-G motif; other site 266835015320 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 266835015321 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 266835015322 Ligand Binding Site [chemical binding]; other site 266835015323 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 266835015324 magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517 266835015325 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 266835015326 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 266835015327 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 266835015328 motif II; other site 266835015329 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 266835015330 FOG: CBS domain [General function prediction only]; Region: COG0517 266835015331 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the BON (bacterial OsmY and nodulation domain) domain. BON is a putative phospholipid-binding domain found in a family of osmotic shock protection...; Region: CBS_pair_BON_assoc; cd04586 266835015332 BON domain; Region: BON; pfam04972 266835015333 Predicted membrane protein [Function unknown]; Region: COG4244 266835015334 Predicted membrane protein [Function unknown]; Region: COG3212 266835015335 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 266835015336 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 266835015337 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266835015338 active site 266835015339 phosphorylation site [posttranslational modification] 266835015340 intermolecular recognition site; other site 266835015341 dimerization interface [polypeptide binding]; other site 266835015342 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266835015343 DNA binding site [nucleotide binding] 266835015344 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 266835015345 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266835015346 ATP binding site [chemical binding]; other site 266835015347 Mg2+ binding site [ion binding]; other site 266835015348 G-X-G motif; other site 266835015349 Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrB [Energy production and conversion]; Region: NqrB; COG1805 266835015350 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 266835015351 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cd00322 266835015352 FAD binding pocket [chemical binding]; other site 266835015353 conserved FAD binding motif [chemical binding]; other site 266835015354 phosphate binding motif [ion binding]; other site 266835015355 beta-alpha-beta structure motif; other site 266835015356 NAD binding pocket [chemical binding]; other site 266835015357 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 266835015358 ApbE family; Region: ApbE; pfam02424 266835015359 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3976 266835015360 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 266835015361 Uncharacterized protein, possibly involved in nitrogen fixation [Inorganic ion transport and metabolism]; Region: FixS; COG3197 266835015362 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 266835015363 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 266835015364 metal-binding site [ion binding] 266835015365 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 266835015366 Soluble P-type ATPase [General function prediction only]; Region: COG4087 266835015367 Predicted integral membrane protein linked to a cation pump [Inorganic ion transport and metabolism]; Region: COG5456 266835015368 FixH; Region: FixH; pfam05751 266835015369 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 266835015370 4Fe-4S binding domain; Region: Fer4_5; pfam12801 266835015371 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 266835015372 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 266835015373 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 266835015374 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 266835015375 Cytochrome cbb oxidase CcoQ. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of O2...; Region: cbb3_Oxidase_CcoQ; cd01324 266835015376 Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993 266835015377 Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; pfam02433 266835015378 Cytochrome cbb3 oxidase subunit I. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661 266835015379 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 266835015380 Low-spin heme binding site [chemical binding]; other site 266835015381 Putative water exit pathway; other site 266835015382 Binuclear center (active site) [active] 266835015383 Putative proton exit pathway; other site 266835015384 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 266835015385 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 266835015386 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 266835015387 ligand binding site [chemical binding]; other site 266835015388 flexible hinge region; other site 266835015389 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 266835015390 putative switch regulator; other site 266835015391 non-specific DNA interactions [nucleotide binding]; other site 266835015392 DNA binding site [nucleotide binding] 266835015393 sequence specific DNA binding site [nucleotide binding]; other site 266835015394 putative cAMP binding site [chemical binding]; other site 266835015395 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 266835015396 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 266835015397 FeS/SAM binding site; other site 266835015398 Ion channel; Region: Ion_trans_2; pfam07885 266835015399 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3564 266835015400 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 266835015401 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 266835015402 NAD(P) binding site [chemical binding]; other site 266835015403 catalytic residues [active] 266835015404 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 266835015405 GAF domain; Region: GAF; pfam01590 266835015406 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 266835015407 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 266835015408 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 266835015409 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 266835015410 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 266835015411 active site 266835015412 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 266835015413 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 266835015414 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 266835015415 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 266835015416 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 266835015417 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 266835015418 PYR/PP interface [polypeptide binding]; other site 266835015419 dimer interface [polypeptide binding]; other site 266835015420 TPP binding site [chemical binding]; other site 266835015421 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 266835015422 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 266835015423 TPP-binding site [chemical binding]; other site 266835015424 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 266835015425 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 266835015426 NAD binding site [chemical binding]; other site 266835015427 dimerization interface [polypeptide binding]; other site 266835015428 product binding site; other site 266835015429 substrate binding site [chemical binding]; other site 266835015430 zinc binding site [ion binding]; other site 266835015431 catalytic residues [active] 266835015432 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 266835015433 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 266835015434 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835015435 dimer interface [polypeptide binding]; other site 266835015436 putative PBP binding loops; other site 266835015437 ABC-ATPase subunit interface; other site 266835015438 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 266835015439 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835015440 dimer interface [polypeptide binding]; other site 266835015441 conserved gate region; other site 266835015442 putative PBP binding loops; other site 266835015443 ABC-ATPase subunit interface; other site 266835015444 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 266835015445 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 266835015446 Walker A/P-loop; other site 266835015447 ATP binding site [chemical binding]; other site 266835015448 Q-loop/lid; other site 266835015449 ABC transporter signature motif; other site 266835015450 Walker B; other site 266835015451 D-loop; other site 266835015452 H-loop/switch region; other site 266835015453 TOBE domain; Region: TOBE; pfam03459 266835015454 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 266835015455 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 266835015456 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 266835015457 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 266835015458 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 266835015459 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 266835015460 Protein of unknown function (DUF1349); Region: DUF1349; cl01397 266835015461 Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA_3; cd08770 266835015462 SxDxEG motif; other site 266835015463 putative active site [active] 266835015464 putative metal binding site [ion binding]; other site 266835015465 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 266835015466 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 266835015467 catalytic residue [active] 266835015468 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 266835015469 Beta-lactamase; Region: Beta-lactamase; pfam00144 266835015470 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 266835015471 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Bacterial Cryptic D-Serine Dehydratase; Region: PLPDE_III_cryptic_DSD; cd06818 266835015472 dimer interface [polypeptide binding]; other site 266835015473 active site 266835015474 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 266835015475 substrate binding site [chemical binding]; other site 266835015476 catalytic residue [active] 266835015477 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 266835015478 hydroxyglutarate oxidase; Provisional; Region: PRK11728 266835015479 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 266835015480 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266835015481 non-specific DNA binding site [nucleotide binding]; other site 266835015482 salt bridge; other site 266835015483 sequence-specific DNA binding site [nucleotide binding]; other site 266835015484 Cupin domain; Region: Cupin_2; pfam07883 266835015485 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 266835015486 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 266835015487 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 266835015488 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835015489 dimer interface [polypeptide binding]; other site 266835015490 conserved gate region; other site 266835015491 putative PBP binding loops; other site 266835015492 ABC-ATPase subunit interface; other site 266835015493 D-ala-D-ala transporter subunit; Provisional; Region: PRK09881 266835015494 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835015495 dimer interface [polypeptide binding]; other site 266835015496 conserved gate region; other site 266835015497 putative PBP binding loops; other site 266835015498 ABC-ATPase subunit interface; other site 266835015499 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 266835015500 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266835015501 Walker A/P-loop; other site 266835015502 ATP binding site [chemical binding]; other site 266835015503 Q-loop/lid; other site 266835015504 ABC transporter signature motif; other site 266835015505 Walker B; other site 266835015506 D-loop; other site 266835015507 H-loop/switch region; other site 266835015508 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 266835015509 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 266835015510 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266835015511 Walker A/P-loop; other site 266835015512 ATP binding site [chemical binding]; other site 266835015513 Q-loop/lid; other site 266835015514 ABC transporter signature motif; other site 266835015515 Walker B; other site 266835015516 D-loop; other site 266835015517 H-loop/switch region; other site 266835015518 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 266835015519 Uncharacterized conserved protein [Function unknown]; Region: COG5476 266835015520 Protein of unknown function (DUF1485); Region: DUF1485; pfam07364 266835015521 MlrC C-terminus; Region: MlrC_C; pfam07171 266835015522 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 266835015523 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266835015524 DNA binding site [nucleotide binding] 266835015525 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 266835015526 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 266835015527 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266835015528 DNA binding site [nucleotide binding] 266835015529 Predicted ATPase [General function prediction only]; Region: COG3903 266835015530 Epoxide hydrolase N terminus; Region: EHN; pfam06441 266835015531 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 266835015532 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 266835015533 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 266835015534 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 266835015535 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 266835015536 putative active site [active] 266835015537 putative catalytic site [active] 266835015538 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 266835015539 classical (c) SDRs; Region: SDR_c; cd05233 266835015540 NAD(P) binding site [chemical binding]; other site 266835015541 active site 266835015542 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 266835015543 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835015544 Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467 266835015545 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 266835015546 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266835015547 putative active site [active] 266835015548 heme pocket [chemical binding]; other site 266835015549 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266835015550 dimer interface [polypeptide binding]; other site 266835015551 phosphorylation site [posttranslational modification] 266835015552 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266835015553 ATP binding site [chemical binding]; other site 266835015554 Mg2+ binding site [ion binding]; other site 266835015555 G-X-G motif; other site 266835015556 Response regulator receiver domain; Region: Response_reg; pfam00072 266835015557 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266835015558 active site 266835015559 phosphorylation site [posttranslational modification] 266835015560 intermolecular recognition site; other site 266835015561 dimerization interface [polypeptide binding]; other site 266835015562 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266835015563 active site 266835015564 phosphorylation site [posttranslational modification] 266835015565 intermolecular recognition site; other site 266835015566 Response regulator receiver domain; Region: Response_reg; pfam00072 266835015567 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266835015568 active site 266835015569 phosphorylation site [posttranslational modification] 266835015570 intermolecular recognition site; other site 266835015571 dimerization interface [polypeptide binding]; other site 266835015572 Response regulator receiver domain; Region: Response_reg; pfam00072 266835015573 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266835015574 active site 266835015575 phosphorylation site [posttranslational modification] 266835015576 intermolecular recognition site; other site 266835015577 dimerization interface [polypeptide binding]; other site 266835015578 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266835015579 binding surface 266835015580 TPR motif; other site 266835015581 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 266835015582 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266835015583 binding surface 266835015584 TPR motif; other site 266835015585 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 266835015586 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 266835015587 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 266835015588 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 266835015589 DXD motif; other site 266835015590 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 266835015591 putative binding surface; other site 266835015592 active site 266835015593 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 266835015594 active site 266835015595 DNA binding site [nucleotide binding] 266835015596 Uncharacterized conserved protein [Function unknown]; Region: COG5439 266835015597 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5381 266835015598 Cache domain; Region: Cache_1; pfam02743 266835015599 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 266835015600 dimerization interface [polypeptide binding]; other site 266835015601 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 266835015602 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 266835015603 Methyltransferase domain; Region: Methyltransf_31; pfam13847 266835015604 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266835015605 S-adenosylmethionine binding site [chemical binding]; other site 266835015606 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 266835015607 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 266835015608 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 266835015609 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266835015610 metal binding site [ion binding]; metal-binding site 266835015611 active site 266835015612 I-site; other site 266835015613 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 266835015614 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 266835015615 short chain dehydrogenase; Provisional; Region: PRK06138 266835015616 classical (c) SDRs; Region: SDR_c; cd05233 266835015617 NAD(P) binding site [chemical binding]; other site 266835015618 active site 266835015619 Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992 266835015620 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 266835015621 inhibitor-cofactor binding pocket; inhibition site 266835015622 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266835015623 catalytic residue [active] 266835015624 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 266835015625 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 266835015626 substrate binding site [chemical binding]; other site 266835015627 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 266835015628 classical (c) SDRs; Region: SDR_c; cd05233 266835015629 NAD(P) binding site [chemical binding]; other site 266835015630 active site 266835015631 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 266835015632 Isochorismatase family; Region: Isochorismatase; pfam00857 266835015633 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 266835015634 catalytic triad [active] 266835015635 conserved cis-peptide bond; other site 266835015636 Propanediol dehydratase, small subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduE; COG4910 266835015637 Propanediol dehydratase, large subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduC; COG4909 266835015638 Dehydratase large subunit. This family contains the large (alpha) subunit of B12-dependent glycerol dehydratases (GDHs) and B12-dependent diol dehydratases (DDHs). GDH is isofunctional with DDH. These enzymes can each catalyze the conversion of 1; Region: Dehydratase_LU; cd03687 266835015639 alpha-alpha subunit/dimer interface [polypeptide binding]; other site 266835015640 alpha-beta subunit interface [polypeptide binding]; other site 266835015641 alpha-gamma subunit interface [polypeptide binding]; other site 266835015642 active site 266835015643 substrate and K+ binding site; other site 266835015644 K+ binding site [ion binding]; other site 266835015645 cobalamin binding site [chemical binding]; other site 266835015646 Dehydratase medium subunit; Region: Dehydratase_MU; cl17703 266835015647 Predicted membrane protein [Function unknown]; Region: COG4425 266835015648 Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081 266835015649 Predicted membrane protein [Function unknown]; Region: COG4803 266835015650 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 266835015651 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 266835015652 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266835015653 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 266835015654 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 266835015655 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 266835015656 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 266835015657 HlyD family secretion protein; Region: HlyD_3; pfam13437 266835015658 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 266835015659 arginine deiminase; Provisional; Region: PRK01388 266835015660 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 266835015661 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 266835015662 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 266835015663 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 266835015664 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 266835015665 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 266835015666 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 266835015667 active site 266835015668 catalytic tetrad [active] 266835015669 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 266835015670 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266835015671 S-adenosylmethionine binding site [chemical binding]; other site 266835015672 acyl-CoA ligase (AMP-forming), exosortase A-associated; Region: ligase_PEP_1; TIGR03098 266835015673 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 266835015674 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_6; cd05922 266835015675 acyl-activating enzyme (AAE) consensus motif; other site 266835015676 putative AMP binding site [chemical binding]; other site 266835015677 putative active site [active] 266835015678 putative CoA binding site [chemical binding]; other site 266835015679 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 266835015680 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 266835015681 dimer interface [polypeptide binding]; other site 266835015682 active site 266835015683 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 266835015684 Ligand Binding Site [chemical binding]; other site 266835015685 Molecular Tunnel; other site 266835015686 NAD synthetase; Reviewed; Region: nadE; PRK00876 266835015687 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 266835015688 homodimer interface [polypeptide binding]; other site 266835015689 NAD binding pocket [chemical binding]; other site 266835015690 ATP binding pocket [chemical binding]; other site 266835015691 Mg binding site [ion binding]; other site 266835015692 active-site loop [active] 266835015693 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 266835015694 AMP-binding enzyme; Region: AMP-binding; pfam00501 266835015695 acyl-activating enzyme (AAE) consensus motif; other site 266835015696 AMP binding site [chemical binding]; other site 266835015697 active site 266835015698 CoA binding site [chemical binding]; other site 266835015699 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 266835015700 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 266835015701 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 266835015702 TMP-binding site; other site 266835015703 ATP-binding site [chemical binding]; other site 266835015704 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 266835015705 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 266835015706 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 266835015707 acyl-activating enzyme (AAE) consensus motif; other site 266835015708 AMP binding site [chemical binding]; other site 266835015709 active site 266835015710 CoA binding site [chemical binding]; other site 266835015711 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 266835015712 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 266835015713 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 266835015714 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 266835015715 putative ADP-binding pocket [chemical binding]; other site 266835015716 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 266835015717 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 266835015718 active site 266835015719 dimer interface [polypeptide binding]; other site 266835015720 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 266835015721 Ligand Binding Site [chemical binding]; other site 266835015722 Molecular Tunnel; other site 266835015723 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 266835015724 Chain length determinant protein; Region: Wzz; cl15801 266835015725 AAA domain; Region: AAA_31; pfam13614 266835015726 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 266835015727 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 266835015728 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 266835015729 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 266835015730 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 266835015731 putative NAD(P) binding site [chemical binding]; other site 266835015732 active site 266835015733 putative substrate binding site [chemical binding]; other site 266835015734 DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771 266835015735 DNA binding residues [nucleotide binding] 266835015736 dimerization interface [polypeptide binding]; other site 266835015737 PAS domain S-box; Region: sensory_box; TIGR00229 266835015738 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266835015739 putative active site [active] 266835015740 heme pocket [chemical binding]; other site 266835015741 PAS fold; Region: PAS_3; pfam08447 266835015742 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 266835015743 HWE histidine kinase; Region: HWE_HK; pfam07536 266835015744 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 266835015745 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266835015746 active site 266835015747 phosphorylation site [posttranslational modification] 266835015748 intermolecular recognition site; other site 266835015749 dimerization interface [polypeptide binding]; other site 266835015750 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266835015751 DNA binding residues [nucleotide binding] 266835015752 dimerization interface [polypeptide binding]; other site 266835015753 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 266835015754 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 266835015755 active site 266835015756 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 266835015757 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 266835015758 inhibitor-cofactor binding pocket; inhibition site 266835015759 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266835015760 catalytic residue [active] 266835015761 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 266835015762 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 266835015763 NAD dependent epimerase/dehydratase, LLPSF_EDH_00030 family; Region: EDH_00030; TIGR04180 266835015764 NAD binding site [chemical binding]; other site 266835015765 substrate binding site [chemical binding]; other site 266835015766 active site 266835015767 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 266835015768 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 266835015769 Methyltransferase domain; Region: Methyltransf_31; pfam13847 266835015770 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266835015771 S-adenosylmethionine binding site [chemical binding]; other site 266835015772 ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618 266835015773 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 266835015774 ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246 266835015775 Walker A/P-loop; other site 266835015776 ATP binding site [chemical binding]; other site 266835015777 Q-loop/lid; other site 266835015778 ABC transporter signature motif; other site 266835015779 Walker B; other site 266835015780 D-loop; other site 266835015781 H-loop/switch region; other site 266835015782 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 266835015783 HlyD family secretion protein; Region: HlyD_3; pfam13437 266835015784 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 266835015785 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 266835015786 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 266835015787 glutaminase active site [active] 266835015788 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 266835015789 dimer interface [polypeptide binding]; other site 266835015790 active site 266835015791 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 266835015792 dimer interface [polypeptide binding]; other site 266835015793 active site 266835015794 ornithine cyclodeaminase; Validated; Region: PRK07589 266835015795 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 266835015796 Arginase family; Region: Arginase; cd09989 266835015797 active site 266835015798 Mn binding site [ion binding]; other site 266835015799 oligomer interface [polypeptide binding]; other site 266835015800 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 266835015801 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 266835015802 AsnC family; Region: AsnC_trans_reg; pfam01037 266835015803 Transcriptional regulators [Transcription]; Region: GntR; COG1802 266835015804 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266835015805 DNA-binding site [nucleotide binding]; DNA binding site 266835015806 FCD domain; Region: FCD; pfam07729 266835015807 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266835015808 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266835015809 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266835015810 dimerization interface [polypeptide binding]; other site 266835015811 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 266835015812 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 266835015813 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 266835015814 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 266835015815 Transcriptional regulators [Transcription]; Region: GntR; COG1802 266835015816 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266835015817 DNA-binding site [nucleotide binding]; DNA binding site 266835015818 FCD domain; Region: FCD; pfam07729 266835015819 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 266835015820 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 266835015821 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 266835015822 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 266835015823 hypothetical protein; Provisional; Region: PRK07236 266835015824 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 266835015825 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 266835015826 Amino acid synthesis; Region: AA_synth; pfam06684 266835015827 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 266835015828 substrate binding site [chemical binding]; other site 266835015829 Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases [Carbohydrate transport and metabolism]; Region: AraD; COG0235 266835015830 intersubunit interface [polypeptide binding]; other site 266835015831 active site 266835015832 Zn2+ binding site [ion binding]; other site 266835015833 choline dehydrogenase; Validated; Region: PRK02106 266835015834 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 266835015835 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK06130 266835015836 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 266835015837 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 266835015838 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 266835015839 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 266835015840 Walker A/P-loop; other site 266835015841 ATP binding site [chemical binding]; other site 266835015842 Q-loop/lid; other site 266835015843 ABC transporter signature motif; other site 266835015844 Walker B; other site 266835015845 D-loop; other site 266835015846 H-loop/switch region; other site 266835015847 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 266835015848 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835015849 dimer interface [polypeptide binding]; other site 266835015850 conserved gate region; other site 266835015851 ABC-ATPase subunit interface; other site 266835015852 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 266835015853 NMT1/THI5 like; Region: NMT1; pfam09084 266835015854 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 266835015855 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 266835015856 putative ligand binding site [chemical binding]; other site 266835015857 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 266835015858 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 266835015859 Walker A/P-loop; other site 266835015860 ATP binding site [chemical binding]; other site 266835015861 Q-loop/lid; other site 266835015862 ABC transporter signature motif; other site 266835015863 Walker B; other site 266835015864 D-loop; other site 266835015865 H-loop/switch region; other site 266835015866 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 266835015867 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 266835015868 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 266835015869 TM-ABC transporter signature motif; other site 266835015870 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 266835015871 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 266835015872 TM-ABC transporter signature motif; other site 266835015873 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 266835015874 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 266835015875 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 266835015876 catalytic residue [active] 266835015877 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 266835015878 classical (c) SDRs; Region: SDR_c; cd05233 266835015879 NAD(P) binding site [chemical binding]; other site 266835015880 active site 266835015881 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 266835015882 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 266835015883 inhibitor site; inhibition site 266835015884 active site 266835015885 dimer interface [polypeptide binding]; other site 266835015886 catalytic residue [active] 266835015887 Proline racemase [Amino acid transport and metabolism]; Region: COG3938 266835015888 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 266835015889 Beta-lactamase; Region: Beta-lactamase; pfam00144 266835015890 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 266835015891 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 266835015892 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 266835015893 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 266835015894 Type II secretory pathway, component PulK [Intracellular trafficking and secretion]; Region: PulK; COG3156 266835015895 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 266835015896 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 266835015897 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 266835015898 Walker A motif; other site 266835015899 ATP binding site [chemical binding]; other site 266835015900 Walker B motif; other site 266835015901 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 266835015902 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 266835015903 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 266835015904 type II secretion system protein H; Region: typeII_sec_gspH; TIGR01708 266835015905 Type II secretory pathway, component PulJ [Intracellular trafficking and secretion]; Region: PulJ; COG4795 266835015906 Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612 266835015907 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 266835015908 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 266835015909 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 266835015910 Type II secretory pathway, component PulD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulD; COG1450 266835015911 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 266835015912 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 266835015913 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 266835015914 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943 266835015915 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943 266835015916 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943 266835015917 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943 266835015918 Insecticide toxin TcdB middle/N-terminal region; Region: TcdB_toxin_midN; pfam12256 266835015919 Insecticide toxin TcdB middle/C-terminal region; Region: TcdB_toxin_midC; pfam12255 266835015920 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 266835015921 RHS Repeat; Region: RHS_repeat; pfam05593 266835015922 RHS Repeat; Region: RHS_repeat; pfam05593 266835015923 RHS Repeat; Region: RHS_repeat; pfam05593 266835015924 RHS Repeat; Region: RHS_repeat; cl11982 266835015925 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 266835015926 Transcriptional regulators [Transcription]; Region: MarR; COG1846 266835015927 MarR family; Region: MarR_2; pfam12802 266835015928 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 266835015929 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266835015930 putative substrate translocation pore; other site 266835015931 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266835015932 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 266835015933 Prostaglandin dehydrogenases; Region: PGDH; cd05288 266835015934 NAD(P) binding site [chemical binding]; other site 266835015935 substrate binding site [chemical binding]; other site 266835015936 dimer interface [polypeptide binding]; other site 266835015937 metabolite-proton symporter; Region: 2A0106; TIGR00883 266835015938 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266835015939 putative substrate translocation pore; other site 266835015940 cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433 266835015941 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 266835015942 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 266835015943 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 266835015944 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 266835015945 D-pathway; other site 266835015946 Putative ubiquinol binding site [chemical binding]; other site 266835015947 Low-spin heme (heme b) binding site [chemical binding]; other site 266835015948 Putative water exit pathway; other site 266835015949 Binuclear center (heme o3/CuB) [ion binding]; other site 266835015950 K-pathway; other site 266835015951 Putative proton exit pathway; other site 266835015952 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 266835015953 Subunit I/III interface [polypeptide binding]; other site 266835015954 Subunit III/IV interface [polypeptide binding]; other site 266835015955 cytochrome o ubiquinol oxidase subunit IV; Region: CyoD; TIGR02847 266835015956 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 266835015957 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 266835015958 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266835015959 dimer interface [polypeptide binding]; other site 266835015960 phosphorylation site [posttranslational modification] 266835015961 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266835015962 ATP binding site [chemical binding]; other site 266835015963 Mg2+ binding site [ion binding]; other site 266835015964 G-X-G motif; other site 266835015965 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567 266835015966 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266835015967 active site 266835015968 phosphorylation site [posttranslational modification] 266835015969 intermolecular recognition site; other site 266835015970 dimerization interface [polypeptide binding]; other site 266835015971 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 266835015972 Isochorismatase family; Region: Isochorismatase; pfam00857 266835015973 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 266835015974 catalytic triad [active] 266835015975 conserved cis-peptide bond; other site 266835015976 Uncharacterized conserved protein [Function unknown]; Region: COG1415 266835015977 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378 266835015978 trimer interface [polypeptide binding]; other site 266835015979 putative Zn binding site [ion binding]; other site 266835015980 short chain dehydrogenase; Provisional; Region: PRK06701 266835015981 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835015982 NAD(P) binding site [chemical binding]; other site 266835015983 active site 266835015984 KTSC domain; Region: KTSC; pfam13619 266835015985 Alkylated DNA repair protein [DNA replication, recombination, and repair]; Region: AlkB; COG3145 266835015986 Alkylated DNA repair protein [DNA replication, recombination, and repair]; Region: AlkB; COG3145 266835015987 classical (c) SDRs; Region: SDR_c; cd05233 266835015988 2-deoxy-D-gluconate 3-dehydrogenase; Provisional; Region: PRK12481 266835015989 NAD(P) binding site [chemical binding]; other site 266835015990 active site 266835015991 Transcriptional regulators [Transcription]; Region: FadR; COG2186 266835015992 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266835015993 DNA-binding site [nucleotide binding]; DNA binding site 266835015994 FCD domain; Region: FCD; pfam07729 266835015995 mannonate dehydratase; Provisional; Region: PRK03906 266835015996 mannonate dehydratase; Region: uxuA; TIGR00695 266835015997 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 266835015998 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 266835015999 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 266835016000 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266835016001 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 266835016002 trimer interface [polypeptide binding]; other site 266835016003 oxyanion hole (OAH) forming residues; other site 266835016004 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 266835016005 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 266835016006 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 266835016007 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266835016008 DNA binding site [nucleotide binding] 266835016009 Predicted ATPase [General function prediction only]; Region: COG3903 266835016010 Uncharacterized conserved protein [Function unknown]; Region: COG2128 266835016011 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 266835016012 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 266835016013 FAD binding domain; Region: FAD_binding_4; pfam01565 266835016014 Berberine and berberine like; Region: BBE; pfam08031 266835016015 N-formylglutamate amidohydrolase; Region: FGase; cl01522 266835016016 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 266835016017 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266835016018 DNA binding residues [nucleotide binding] 266835016019 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 266835016020 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 266835016021 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 266835016022 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 266835016023 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835016024 NAD(P) binding site [chemical binding]; other site 266835016025 active site 266835016026 L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253 266835016027 homodimer interface [polypeptide binding]; other site 266835016028 homotetramer interface [polypeptide binding]; other site 266835016029 active site pocket [active] 266835016030 cleavage site 266835016031 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 266835016032 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 266835016033 generic binding surface II; other site 266835016034 generic binding surface I; other site 266835016035 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266835016036 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266835016037 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266835016038 dimerization interface [polypeptide binding]; other site 266835016039 Uncharacterized conserved protein [Function unknown]; Region: COG5403 266835016040 Gamma-glutamylcysteine synthetase [Coenzyme metabolism]; Region: GshA; COG3572 266835016041 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 266835016042 RNA methyltransferase, RsmE family; Region: TIGR00046 266835016043 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 266835016044 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 266835016045 catalytic triad [active] 266835016046 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 266835016047 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 266835016048 active site 266835016049 metal binding site [ion binding]; metal-binding site 266835016050 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 266835016051 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 266835016052 phosphate binding site [ion binding]; other site 266835016053 transcriptional regulator PdhR; Reviewed; Region: pdhR; PRK09464 266835016054 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266835016055 DNA-binding site [nucleotide binding]; DNA binding site 266835016056 FCD domain; Region: FCD; pfam07729 266835016057 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4949 266835016058 glycolate oxidase subunit GlcD; Provisional; Region: PRK11230 266835016059 FAD binding domain; Region: FAD_binding_4; pfam01565 266835016060 manganese transport regulator MntR; Provisional; Region: PRK11050 266835016061 glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282 266835016062 FAD binding domain; Region: FAD_binding_4; pfam01565 266835016063 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 266835016064 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 266835016065 Cysteine-rich domain; Region: CCG; pfam02754 266835016066 Cysteine-rich domain; Region: CCG; pfam02754 266835016067 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190 266835016068 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 266835016069 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 266835016070 homodimer interface [polypeptide binding]; other site 266835016071 NADP binding site [chemical binding]; other site 266835016072 substrate binding site [chemical binding]; other site 266835016073 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 266835016074 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 266835016075 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 266835016076 Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: HisS; COG0124 266835016077 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 266835016078 dimer interface [polypeptide binding]; other site 266835016079 motif 1; other site 266835016080 motif 2; other site 266835016081 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 266835016082 active site 266835016083 motif 3; other site 266835016084 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 266835016085 anticodon binding site; other site 266835016086 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12295 266835016087 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 266835016088 dimer interface [polypeptide binding]; other site 266835016089 motif 1; other site 266835016090 motif 2; other site 266835016091 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 266835016092 active site 266835016093 motif 3; other site 266835016094 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 266835016095 ATP phosphoribosyltransferase catalytic subunit; Provisional; Region: hisG; PRK13583 266835016096 AMP-binding domain protein; Validated; Region: PRK08315 266835016097 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 266835016098 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 266835016099 acyl-activating enzyme (AAE) consensus motif; other site 266835016100 acyl-activating enzyme (AAE) consensus motif; other site 266835016101 putative AMP binding site [chemical binding]; other site 266835016102 putative active site [active] 266835016103 putative CoA binding site [chemical binding]; other site 266835016104 Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387 266835016105 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 266835016106 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 266835016107 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266835016108 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266835016109 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 266835016110 putative effector binding pocket; other site 266835016111 putative dimerization interface [polypeptide binding]; other site 266835016112 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266835016113 S-adenosylmethionine binding site [chemical binding]; other site 266835016114 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 266835016115 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266835016116 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 266835016117 dimerization interface [polypeptide binding]; other site 266835016118 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 266835016119 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 266835016120 dimer interface [polypeptide binding]; other site 266835016121 active site 266835016122 heme binding site [chemical binding]; other site 266835016123 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 266835016124 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 266835016125 amphipathic channel; other site 266835016126 Asn-Pro-Ala signature motifs; other site 266835016127 NOL1/NOP2/sun family; Region: Nol1_Nop2_Fmu; pfam01189 266835016128 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 266835016129 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 266835016130 CoenzymeA binding site [chemical binding]; other site 266835016131 subunit interaction site [polypeptide binding]; other site 266835016132 PHB binding site; other site 266835016133 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase, putative; Region: MTA/SAH-nuc-hyp; TIGR01705 266835016134 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK06026 266835016135 MarR family; Region: MarR_2; pfam12802 266835016136 Transcriptional regulators [Transcription]; Region: MarR; COG1846 266835016137 GMP synthase; Reviewed; Region: guaA; PRK00074 266835016138 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 266835016139 AMP/PPi binding site [chemical binding]; other site 266835016140 candidate oxyanion hole; other site 266835016141 catalytic triad [active] 266835016142 potential glutamine specificity residues [chemical binding]; other site 266835016143 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 266835016144 ATP Binding subdomain [chemical binding]; other site 266835016145 Ligand Binding sites [chemical binding]; other site 266835016146 Dimerization subdomain; other site 266835016147 integrase; Provisional; Region: PRK09692 266835016148 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 266835016149 active site 266835016150 Int/Topo IB signature motif; other site 266835016151 HipA N-terminal domain; Region: Couple_hipA; pfam13657 266835016152 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 266835016153 HipA-like N-terminal domain; Region: HipA_N; pfam07805 266835016154 HipA-like C-terminal domain; Region: HipA_C; pfam07804 266835016155 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266835016156 non-specific DNA binding site [nucleotide binding]; other site 266835016157 salt bridge; other site 266835016158 sequence-specific DNA binding site [nucleotide binding]; other site 266835016159 Type IV secretory pathway, VirB10 components [Intracellular trafficking and secretion]; Region: VirB10; COG2948 266835016160 Protein of unknown function (DUF2274); Region: DUF2274; cl02406 266835016161 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 266835016162 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835016163 NAD(P) binding site [chemical binding]; other site 266835016164 active site 266835016165 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266835016166 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 266835016167 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 266835016168 hypothetical protein; Provisional; Region: PRK07036 266835016169 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 266835016170 inhibitor-cofactor binding pocket; inhibition site 266835016171 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266835016172 catalytic residue [active] 266835016173 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 266835016174 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 266835016175 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 266835016176 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266835016177 Walker A/P-loop; other site 266835016178 ATP binding site [chemical binding]; other site 266835016179 Q-loop/lid; other site 266835016180 ABC transporter signature motif; other site 266835016181 Walker B; other site 266835016182 D-loop; other site 266835016183 H-loop/switch region; other site 266835016184 TOBE domain; Region: TOBE_2; pfam08402 266835016185 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835016186 dimer interface [polypeptide binding]; other site 266835016187 conserved gate region; other site 266835016188 putative PBP binding loops; other site 266835016189 ABC-ATPase subunit interface; other site 266835016190 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 266835016191 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835016192 dimer interface [polypeptide binding]; other site 266835016193 conserved gate region; other site 266835016194 putative PBP binding loops; other site 266835016195 ABC-ATPase subunit interface; other site 266835016196 Histone deacetylase class IIa; Region: HDAC_classII_APAH; cd10001 266835016197 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 266835016198 active site 266835016199 Zn binding site [ion binding]; other site 266835016200 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 266835016201 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 266835016202 NAD binding site [chemical binding]; other site 266835016203 catalytic residues [active] 266835016204 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 266835016205 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266835016206 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 266835016207 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266835016208 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 266835016209 dimerization interface [polypeptide binding]; other site 266835016210 substrate binding pocket [chemical binding]; other site 266835016211 putative dimethyl sulfoniopropionate demethylase; Reviewed; Region: dmdA; PRK12486 266835016212 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 266835016213 acyl-CoA synthetase; Validated; Region: PRK08162 266835016214 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; Region: ttLC_FACS_AEE21_like; cd12118 266835016215 acyl-activating enzyme (AAE) consensus motif; other site 266835016216 putative active site [active] 266835016217 AMP binding site [chemical binding]; other site 266835016218 putative CoA binding site [chemical binding]; other site 266835016219 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 266835016220 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 266835016221 active site 266835016222 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 266835016223 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 266835016224 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266835016225 substrate binding site [chemical binding]; other site 266835016226 oxyanion hole (OAH) forming residues; other site 266835016227 trimer interface [polypeptide binding]; other site 266835016228 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 266835016229 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835016230 dimer interface [polypeptide binding]; other site 266835016231 conserved gate region; other site 266835016232 putative PBP binding loops; other site 266835016233 ABC-ATPase subunit interface; other site 266835016234 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 266835016235 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 266835016236 Walker A/P-loop; other site 266835016237 ATP binding site [chemical binding]; other site 266835016238 Q-loop/lid; other site 266835016239 ABC transporter signature motif; other site 266835016240 Walker B; other site 266835016241 D-loop; other site 266835016242 H-loop/switch region; other site 266835016243 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 266835016244 NMT1-like family; Region: NMT1_2; pfam13379 266835016245 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2828 266835016246 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266835016247 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266835016248 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 266835016249 putative dimerization interface [polypeptide binding]; other site 266835016250 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 266835016251 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 266835016252 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 266835016253 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 266835016254 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 266835016255 Subfamily of fatty acid CoA ligase (FACL) similar to Fum10p of Gibberella moniliformis; Region: FACL_fum10p_like; cd05926 266835016256 acyl-activating enzyme (AAE) consensus motif; other site 266835016257 acyl-activating enzyme (AAE) consensus motif; other site 266835016258 putative AMP binding site [chemical binding]; other site 266835016259 putative active site [active] 266835016260 putative CoA binding site [chemical binding]; other site 266835016261 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 266835016262 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 266835016263 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835016264 dimer interface [polypeptide binding]; other site 266835016265 conserved gate region; other site 266835016266 putative PBP binding loops; other site 266835016267 ABC-ATPase subunit interface; other site 266835016268 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 266835016269 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835016270 dimer interface [polypeptide binding]; other site 266835016271 conserved gate region; other site 266835016272 putative PBP binding loops; other site 266835016273 ABC-ATPase subunit interface; other site 266835016274 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 266835016275 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 266835016276 substrate binding pocket [chemical binding]; other site 266835016277 membrane-bound complex binding site; other site 266835016278 hinge residues; other site 266835016279 Transcriptional regulators [Transcription]; Region: GntR; COG1802 266835016280 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266835016281 DNA-binding site [nucleotide binding]; DNA binding site 266835016282 FCD domain; Region: FCD; pfam07729 266835016283 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266835016284 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266835016285 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 266835016286 dimerization interface [polypeptide binding]; other site 266835016287 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 266835016288 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 266835016289 inhibitor-cofactor binding pocket; inhibition site 266835016290 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266835016291 catalytic residue [active] 266835016292 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 266835016293 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 266835016294 Acetyl esterase (deacetylase) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3458 266835016295 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 266835016296 Protein of unknown function (DUF982); Region: DUF982; pfam06169 266835016297 Protein of unknown function (DUF982); Region: DUF982; pfam06169 266835016298 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 266835016299 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266835016300 sequence-specific DNA binding site [nucleotide binding]; other site 266835016301 salt bridge; other site 266835016302 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 266835016303 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 266835016304 Predicted acyl esterases [General function prediction only]; Region: COG2936 266835016305 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 266835016306 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 266835016307 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 266835016308 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 266835016309 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835016310 dimer interface [polypeptide binding]; other site 266835016311 conserved gate region; other site 266835016312 putative PBP binding loops; other site 266835016313 ABC-ATPase subunit interface; other site 266835016314 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 266835016315 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835016316 dimer interface [polypeptide binding]; other site 266835016317 conserved gate region; other site 266835016318 putative PBP binding loops; other site 266835016319 ABC-ATPase subunit interface; other site 266835016320 Protein of unknown function (DUF4038); Region: DUF4038; pfam13204 266835016321 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 266835016322 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 266835016323 Walker A/P-loop; other site 266835016324 ATP binding site [chemical binding]; other site 266835016325 Q-loop/lid; other site 266835016326 ABC transporter signature motif; other site 266835016327 Walker B; other site 266835016328 D-loop; other site 266835016329 H-loop/switch region; other site 266835016330 TOBE domain; Region: TOBE_2; pfam08402 266835016331 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 266835016332 Ribulose 1,5-bisphosphate carboxylase, large subunit [Carbohydrate transport and metabolism]; Region: RbcL; COG1850 266835016333 Ribulose bisphosphate carboxylase like proteins from nonphototrophic bacteria; Region: RLP_NonPhot; cd08207 266835016334 dimer interface [polypeptide binding]; other site 266835016335 active site 266835016336 catalytic residue [active] 266835016337 metal binding site [ion binding]; metal-binding site 266835016338 transcriptional regulator NanR; Provisional; Region: PRK03837 266835016339 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266835016340 DNA-binding site [nucleotide binding]; DNA binding site 266835016341 FCD domain; Region: FCD; pfam07729 266835016342 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 266835016343 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 266835016344 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 266835016345 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 266835016346 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 266835016347 TM-ABC transporter signature motif; other site 266835016348 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 266835016349 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 266835016350 Walker A/P-loop; other site 266835016351 ATP binding site [chemical binding]; other site 266835016352 Q-loop/lid; other site 266835016353 ABC transporter signature motif; other site 266835016354 Walker B; other site 266835016355 D-loop; other site 266835016356 H-loop/switch region; other site 266835016357 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 266835016358 Predicted periplasmic lipoprotein [General function prediction only]; Region: COG5618 266835016359 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 266835016360 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 266835016361 ligand binding site [chemical binding]; other site 266835016362 dimerization interface [polypeptide binding]; other site 266835016363 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 266835016364 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 266835016365 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 266835016366 TM-ABC transporter signature motif; other site 266835016367 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 266835016368 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 266835016369 Walker A/P-loop; other site 266835016370 ATP binding site [chemical binding]; other site 266835016371 Q-loop/lid; other site 266835016372 ABC transporter signature motif; other site 266835016373 Walker B; other site 266835016374 D-loop; other site 266835016375 H-loop/switch region; other site 266835016376 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 266835016377 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 266835016378 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 266835016379 TM-ABC transporter signature motif; other site 266835016380 Periplasmic sugar-binding component of uncharacterized ABC-type transport systems that are members of the pentose/hexose sugar-binding protein family of the type I periplasmic binding protein superfamily; Region: PBP1_ABC_sugar_binding_like_1; cd06300 266835016381 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 266835016382 putative ligand binding site [chemical binding]; other site 266835016383 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 266835016384 hydroxyglutarate oxidase; Provisional; Region: PRK11728 266835016385 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266835016386 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266835016387 The C-terminal substrate-domain of LysR-type transcriptional regulators involved in the catabolism of opines and that of related regulators, contains the type 2 periplasmic binding fold; Region: PBP2_LysR_opines_like; cd08415 266835016388 putative dimerization interface [polypeptide binding]; other site 266835016389 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 266835016390 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 266835016391 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 266835016392 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 266835016393 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 266835016394 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 266835016395 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 266835016396 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 266835016397 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 266835016398 hydroxyglutarate oxidase; Provisional; Region: PRK11728 266835016399 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 266835016400 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266835016401 putative DNA binding site [nucleotide binding]; other site 266835016402 putative Zn2+ binding site [ion binding]; other site 266835016403 AsnC family; Region: AsnC_trans_reg; pfam01037 266835016404 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 266835016405 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266835016406 Walker A/P-loop; other site 266835016407 ATP binding site [chemical binding]; other site 266835016408 Q-loop/lid; other site 266835016409 ABC transporter signature motif; other site 266835016410 Walker B; other site 266835016411 D-loop; other site 266835016412 H-loop/switch region; other site 266835016413 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 266835016414 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266835016415 Walker A/P-loop; other site 266835016416 ATP binding site [chemical binding]; other site 266835016417 Q-loop/lid; other site 266835016418 ABC transporter signature motif; other site 266835016419 Walker B; other site 266835016420 D-loop; other site 266835016421 H-loop/switch region; other site 266835016422 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 266835016423 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 266835016424 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835016425 dimer interface [polypeptide binding]; other site 266835016426 conserved gate region; other site 266835016427 ABC-ATPase subunit interface; other site 266835016428 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 266835016429 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835016430 dimer interface [polypeptide binding]; other site 266835016431 conserved gate region; other site 266835016432 putative PBP binding loops; other site 266835016433 ABC-ATPase subunit interface; other site 266835016434 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 266835016435 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 266835016436 Haloacid dehalogenase superfamily, subfamily IA, variant 2 with 3rd motif like haloacid dehalogenase; Region: HAD-SF-IA-v2; TIGR01493 266835016437 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 266835016438 hypothetical protein; Provisional; Region: PRK05965 266835016439 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 266835016440 inhibitor-cofactor binding pocket; inhibition site 266835016441 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266835016442 catalytic residue [active] 266835016443 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 266835016444 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 266835016445 Coenzyme A binding pocket [chemical binding]; other site 266835016446 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 266835016447 Haloacid dehalogenase superfamily, subfamily IA, variant 2 with 3rd motif like haloacid dehalogenase; Region: HAD-SF-IA-v2; TIGR01493 266835016448 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 266835016449 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 266835016450 succinic semialdehyde dehydrogenase; Region: PLN02278 266835016451 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 266835016452 tetramerization interface [polypeptide binding]; other site 266835016453 NAD(P) binding site [chemical binding]; other site 266835016454 catalytic residues [active] 266835016455 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 266835016456 tartrate dehydrogenase; Region: TTC; TIGR02089 266835016457 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 266835016458 NAD(P)+ dependent aldehyde dehydrogenase family; Region: ALDH; cd07078 266835016459 NAD(P) binding site [chemical binding]; other site 266835016460 catalytic residues [active] 266835016461 Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450 266835016462 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 266835016463 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 266835016464 putative ligand binding site [chemical binding]; other site 266835016465 NAD binding site [chemical binding]; other site 266835016466 dimerization interface [polypeptide binding]; other site 266835016467 catalytic site [active] 266835016468 acetylornithine deacetylase; Provisional; Region: PRK07522 266835016469 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 266835016470 metal binding site [ion binding]; metal-binding site 266835016471 putative dimer interface [polypeptide binding]; other site 266835016472 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 266835016473 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 266835016474 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266835016475 The C-terminal substrate binding domain of LysR-type transcriptional regulator HcaR in involved in 3-phenylpropionic acid catabolism, contains the type2 periplasmic binding fold; Region: PBP2_HcaR; cd08450 266835016476 putative dimerization interface [polypeptide binding]; other site 266835016477 putative substrate binding pocket [chemical binding]; other site 266835016478 short chain dehydrogenase; Provisional; Region: PRK06172 266835016479 classical (c) SDRs; Region: SDR_c; cd05233 266835016480 NAD(P) binding site [chemical binding]; other site 266835016481 active site 266835016482 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 266835016483 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 266835016484 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835016485 NAD(P) binding site [chemical binding]; other site 266835016486 active site 266835016487 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 266835016488 GST_N family, Saccharomyces cerevisiae GTT2-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT2. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing...; Region: GST_N_GTT2_like; cd03051 266835016489 putative C-terminal domain interface [polypeptide binding]; other site 266835016490 putative GSH binding site (G-site) [chemical binding]; other site 266835016491 putative dimer interface [polypeptide binding]; other site 266835016492 C-terminal, alpha helical domain of GTT2-like Glutathione S-transferases; Region: GST_C_GTT2_like; cd03182 266835016493 putative N-terminal domain interface [polypeptide binding]; other site 266835016494 putative dimer interface [polypeptide binding]; other site 266835016495 putative substrate binding pocket (H-site) [chemical binding]; other site 266835016496 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835016497 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 266835016498 active site 266835016499 Transcriptional regulators [Transcription]; Region: GntR; COG1802 266835016500 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266835016501 DNA-binding site [nucleotide binding]; DNA binding site 266835016502 FCD domain; Region: FCD; pfam07729 266835016503 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 266835016504 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 266835016505 putative ligand binding site [chemical binding]; other site 266835016506 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 266835016507 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 266835016508 TM-ABC transporter signature motif; other site 266835016509 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 266835016510 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 266835016511 TM-ABC transporter signature motif; other site 266835016512 Isochorismatase family; Region: Isochorismatase; pfam00857 266835016513 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 266835016514 catalytic triad [active] 266835016515 conserved cis-peptide bond; other site 266835016516 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 266835016517 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 266835016518 Walker A/P-loop; other site 266835016519 ATP binding site [chemical binding]; other site 266835016520 Q-loop/lid; other site 266835016521 ABC transporter signature motif; other site 266835016522 Walker B; other site 266835016523 D-loop; other site 266835016524 H-loop/switch region; other site 266835016525 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 266835016526 Isochorismatase family; Region: Isochorismatase; pfam00857 266835016527 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 266835016528 catalytic triad [active] 266835016529 conserved cis-peptide bond; other site 266835016530 Transcriptional activator [Transcription]; Region: ChrR; COG3806 266835016531 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 266835016532 allophanate hydrolase; Provisional; Region: PRK08186 266835016533 Amidase; Region: Amidase; cl11426 266835016534 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 266835016535 Lysozyme family protein [General function prediction only]; Region: COG5526 266835016536 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 266835016537 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 266835016538 Uncharacterized bacterial family of heme peroxidases; Region: An_peroxidase_bacterial_1; cd09819 266835016539 putative heme binding site [chemical binding]; other site 266835016540 putative substrate binding site [chemical binding]; other site 266835016541 Uncharacterized conserved protein [Function unknown]; Region: COG1944 266835016542 YcaO-like family; Region: YcaO; pfam02624 266835016543 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 266835016544 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 266835016545 TPR motif; other site 266835016546 binding surface 266835016547 Uncharacterized bacterial family of heme peroxidases; Region: An_peroxidase_bacterial_1; cd09819 266835016548 putative heme binding site [chemical binding]; other site 266835016549 putative substrate binding site [chemical binding]; other site 266835016550 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 266835016551 catalytic residues [active] 266835016552 Transcriptional regulators [Transcription]; Region: FadR; COG2186 266835016553 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266835016554 DNA-binding site [nucleotide binding]; DNA binding site 266835016555 FCD domain; Region: FCD; pfam07729 266835016556 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 266835016557 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 266835016558 TM-ABC transporter signature motif; other site 266835016559 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 266835016560 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 266835016561 Walker A/P-loop; other site 266835016562 ATP binding site [chemical binding]; other site 266835016563 Q-loop/lid; other site 266835016564 ABC transporter signature motif; other site 266835016565 Walker B; other site 266835016566 D-loop; other site 266835016567 H-loop/switch region; other site 266835016568 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 266835016569 Periplasmic L-arabinose-binding protein (ABP), a member of a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein superfamily; Region: PBP1_arabinose_binding; cd01540 266835016570 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 266835016571 ligand binding site [chemical binding]; other site 266835016572 short chain dehydrogenase; Provisional; Region: PRK07063 266835016573 classical (c) SDRs; Region: SDR_c; cd05233 266835016574 NAD(P) binding site [chemical binding]; other site 266835016575 active site 266835016576 galactonate dehydratase; Provisional; Region: PRK14017 266835016577 D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325 266835016578 putative active site pocket [active] 266835016579 putative metal binding site [ion binding]; other site 266835016580 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 266835016581 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266835016582 putative metal binding site [ion binding]; other site 266835016583 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 266835016584 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 266835016585 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 266835016586 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 266835016587 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 266835016588 active site 266835016589 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 266835016590 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 266835016591 metal binding site [ion binding]; metal-binding site 266835016592 substrate binding pocket [chemical binding]; other site 266835016593 Transcriptional regulators [Transcription]; Region: GntR; COG1802 266835016594 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266835016595 DNA-binding site [nucleotide binding]; DNA binding site 266835016596 FCD domain; Region: FCD; pfam07729 266835016597 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 266835016598 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 266835016599 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835016600 dimer interface [polypeptide binding]; other site 266835016601 conserved gate region; other site 266835016602 putative PBP binding loops; other site 266835016603 ABC-ATPase subunit interface; other site 266835016604 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 266835016605 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835016606 dimer interface [polypeptide binding]; other site 266835016607 conserved gate region; other site 266835016608 putative PBP binding loops; other site 266835016609 ABC-ATPase subunit interface; other site 266835016610 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 266835016611 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 266835016612 Walker A/P-loop; other site 266835016613 ATP binding site [chemical binding]; other site 266835016614 Q-loop/lid; other site 266835016615 ABC transporter signature motif; other site 266835016616 Walker B; other site 266835016617 D-loop; other site 266835016618 H-loop/switch region; other site 266835016619 TOBE domain; Region: TOBE; pfam03459 266835016620 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 266835016621 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 266835016622 S-formylglutathione hydrolase; Region: PLN02442 266835016623 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 266835016624 Inosine-uridine nucleoside N-ribohydrolase [Nucleotide transport and metabolism]; Region: URH1; COG1957 266835016625 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835016626 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 266835016627 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 266835016628 histidinol-phosphate aminotransferase; Provisional; Region: PRK05166 266835016629 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 266835016630 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266835016631 homodimer interface [polypeptide binding]; other site 266835016632 catalytic residue [active] 266835016633 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835016634 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 266835016635 NAD(P) binding site [chemical binding]; other site 266835016636 active site 266835016637 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 266835016638 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 266835016639 NAD binding site [chemical binding]; other site 266835016640 dimerization interface [polypeptide binding]; other site 266835016641 product binding site; other site 266835016642 substrate binding site [chemical binding]; other site 266835016643 zinc binding site [ion binding]; other site 266835016644 catalytic residues [active] 266835016645 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 266835016646 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 266835016647 NAD(P) binding site [chemical binding]; other site 266835016648 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 266835016649 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266835016650 DNA-binding site [nucleotide binding]; DNA binding site 266835016651 UTRA domain; Region: UTRA; pfam07702 266835016652 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 266835016653 ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427 266835016654 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 266835016655 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835016656 dimer interface [polypeptide binding]; other site 266835016657 conserved gate region; other site 266835016658 putative PBP binding loops; other site 266835016659 ABC-ATPase subunit interface; other site 266835016660 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 266835016661 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 266835016662 Walker A/P-loop; other site 266835016663 ATP binding site [chemical binding]; other site 266835016664 Q-loop/lid; other site 266835016665 ABC transporter signature motif; other site 266835016666 Walker B; other site 266835016667 D-loop; other site 266835016668 H-loop/switch region; other site 266835016669 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 266835016670 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 266835016671 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 266835016672 Walker A/P-loop; other site 266835016673 ATP binding site [chemical binding]; other site 266835016674 Q-loop/lid; other site 266835016675 ABC transporter signature motif; other site 266835016676 Walker B; other site 266835016677 D-loop; other site 266835016678 H-loop/switch region; other site 266835016679 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 266835016680 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 266835016681 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266835016682 Walker A/P-loop; other site 266835016683 ATP binding site [chemical binding]; other site 266835016684 Q-loop/lid; other site 266835016685 ABC transporter signature motif; other site 266835016686 Walker B; other site 266835016687 D-loop; other site 266835016688 H-loop/switch region; other site 266835016689 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 266835016690 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 266835016691 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 266835016692 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 266835016693 NAD binding site [chemical binding]; other site 266835016694 Alpha/beta hydrolase of unknown function (DUF900); Region: DUF900; pfam05990 266835016695 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 266835016696 active sites [active] 266835016697 tetramer interface [polypeptide binding]; other site 266835016698 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR9; cd08274 266835016699 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 266835016700 putative NAD(P) binding site [chemical binding]; other site 266835016701 hypothetical protein; Provisional; Region: PRK07482 266835016702 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 266835016703 inhibitor-cofactor binding pocket; inhibition site 266835016704 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266835016705 catalytic residue [active] 266835016706 succinic semialdehyde dehydrogenase; Region: PLN02278 266835016707 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 266835016708 tetramerization interface [polypeptide binding]; other site 266835016709 NAD(P) binding site [chemical binding]; other site 266835016710 catalytic residues [active] 266835016711 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 266835016712 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266835016713 putative DNA binding site [nucleotide binding]; other site 266835016714 putative Zn2+ binding site [ion binding]; other site 266835016715 AsnC family; Region: AsnC_trans_reg; pfam01037 266835016716 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 266835016717 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266835016718 DNA-binding site [nucleotide binding]; DNA binding site 266835016719 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 266835016720 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266835016721 homodimer interface [polypeptide binding]; other site 266835016722 catalytic residue [active] 266835016723 ectoine/hydroxyectoine ABC transporter, ATP-binding protein; Region: ectoine_ehuA; TIGR03005 266835016724 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266835016725 Walker A/P-loop; other site 266835016726 ATP binding site [chemical binding]; other site 266835016727 Q-loop/lid; other site 266835016728 ABC transporter signature motif; other site 266835016729 Walker B; other site 266835016730 D-loop; other site 266835016731 H-loop/switch region; other site 266835016732 ectoine/hydroxyectoine ABC transporter solute-binding protein; Region: ectoine_ehuB; TIGR02995 266835016733 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 266835016734 substrate binding pocket [chemical binding]; other site 266835016735 membrane-bound complex binding site; other site 266835016736 hinge residues; other site 266835016737 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 266835016738 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835016739 dimer interface [polypeptide binding]; other site 266835016740 conserved gate region; other site 266835016741 putative PBP binding loops; other site 266835016742 ABC-ATPase subunit interface; other site 266835016743 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835016744 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 266835016745 dimer interface [polypeptide binding]; other site 266835016746 conserved gate region; other site 266835016747 putative PBP binding loops; other site 266835016748 ABC-ATPase subunit interface; other site 266835016749 ectoine utilization protein EutA; Region: ectoine_eutA; TIGR02990 266835016750 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 266835016751 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 266835016752 tetramer interface [polypeptide binding]; other site 266835016753 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266835016754 catalytic residue [active] 266835016755 ectoine utilization protein EutC; Validated; Region: PRK08291 266835016756 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 266835016757 ectoine utilization protein EutD; Region: ectoine_eutD; TIGR02993 266835016758 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 266835016759 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 266835016760 active site 266835016761 ectoine utilization protein EutE; Region: ectoine_eutE; TIGR02994 266835016762 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_2; cd06252 266835016763 putative active site [active] 266835016764 Zn binding site [ion binding]; other site 266835016765 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 266835016766 Transcriptional regulators [Transcription]; Region: GntR; COG1802 266835016767 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266835016768 DNA-binding site [nucleotide binding]; DNA binding site 266835016769 FCD domain; Region: FCD; pfam07729 266835016770 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 266835016771 active site 2 [active] 266835016772 active site 1 [active] 266835016773 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 266835016774 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 266835016775 Uncharacterized conserved protein [Function unknown]; Region: COG3254 266835016776 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 266835016777 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 266835016778 active site pocket [active] 266835016779 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 266835016780 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 266835016781 Walker A/P-loop; other site 266835016782 ATP binding site [chemical binding]; other site 266835016783 Q-loop/lid; other site 266835016784 ABC transporter signature motif; other site 266835016785 Walker B; other site 266835016786 D-loop; other site 266835016787 H-loop/switch region; other site 266835016788 TOBE domain; Region: TOBE_2; pfam08402 266835016789 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 266835016790 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835016791 dimer interface [polypeptide binding]; other site 266835016792 conserved gate region; other site 266835016793 putative PBP binding loops; other site 266835016794 ABC-ATPase subunit interface; other site 266835016795 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835016796 dimer interface [polypeptide binding]; other site 266835016797 conserved gate region; other site 266835016798 putative PBP binding loops; other site 266835016799 ABC-ATPase subunit interface; other site 266835016800 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 266835016801 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 266835016802 Transcriptional regulator [Transcription]; Region: IclR; COG1414 266835016803 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266835016804 putative DNA binding site [nucleotide binding]; other site 266835016805 putative Zn2+ binding site [ion binding]; other site 266835016806 Bacterial transcriptional regulator; Region: IclR; pfam01614 266835016807 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 266835016808 Amidohydrolase; Region: Amidohydro_2; pfam04909 266835016809 active site 266835016810 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 266835016811 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 266835016812 CoA-transferase family III; Region: CoA_transf_3; pfam02515 266835016813 Acyl dehydratase [Lipid metabolism]; Region: MaoC; COG2030 266835016814 active site 2 [active] 266835016815 active site 1 [active] 266835016816 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4395 266835016817 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3809 266835016818 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR2; cd08268 266835016819 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 266835016820 putative NAD(P) binding site [chemical binding]; other site 266835016821 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266835016822 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266835016823 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_6; cd08475 266835016824 putative effector binding pocket; other site 266835016825 putative dimerization interface [polypeptide binding]; other site 266835016826 acetolactate synthase; Reviewed; Region: PRK08322 266835016827 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 266835016828 PYR/PP interface [polypeptide binding]; other site 266835016829 dimer interface [polypeptide binding]; other site 266835016830 TPP binding site [chemical binding]; other site 266835016831 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 266835016832 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 266835016833 TPP-binding site [chemical binding]; other site 266835016834 dimer interface [polypeptide binding]; other site 266835016835 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 266835016836 acetylornithine deacetylase; Provisional; Region: PRK06837 266835016837 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like2; cd03895 266835016838 metal binding site [ion binding]; metal-binding site 266835016839 dimer interface [polypeptide binding]; other site 266835016840 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 266835016841 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 266835016842 active site 266835016843 ATP binding site [chemical binding]; other site 266835016844 substrate binding site [chemical binding]; other site 266835016845 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 266835016846 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 266835016847 inhibitor-cofactor binding pocket; inhibition site 266835016848 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266835016849 catalytic residue [active] 266835016850 Transcriptional regulators [Transcription]; Region: GntR; COG1802 266835016851 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266835016852 DNA-binding site [nucleotide binding]; DNA binding site 266835016853 FCD domain; Region: FCD; pfam07729 266835016854 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 266835016855 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 266835016856 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 266835016857 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 266835016858 TM-ABC transporter signature motif; other site 266835016859 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 266835016860 TM-ABC transporter signature motif; other site 266835016861 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 266835016862 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 266835016863 Walker A/P-loop; other site 266835016864 ATP binding site [chemical binding]; other site 266835016865 Q-loop/lid; other site 266835016866 ABC transporter signature motif; other site 266835016867 Walker B; other site 266835016868 D-loop; other site 266835016869 H-loop/switch region; other site 266835016870 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 266835016871 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 266835016872 Walker A/P-loop; other site 266835016873 ATP binding site [chemical binding]; other site 266835016874 Q-loop/lid; other site 266835016875 ABC transporter signature motif; other site 266835016876 Walker B; other site 266835016877 D-loop; other site 266835016878 H-loop/switch region; other site 266835016879 Transcriptional regulators [Transcription]; Region: GntR; COG1802 266835016880 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266835016881 DNA-binding site [nucleotide binding]; DNA binding site 266835016882 FCD domain; Region: FCD; pfam07729 266835016883 Protein of unknown function (DUF3830); Region: DUF3830; pfam12903 266835016884 TIGR04076 family protein; Region: TIGR04076 266835016885 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 266835016886 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 266835016887 active site 266835016888 catalytic tetrad [active] 266835016889 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4460 266835016890 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 266835016891 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_11; cd06346 266835016892 putative ligand binding site [chemical binding]; other site 266835016893 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 266835016894 FAD binding domain; Region: FAD_binding_4; pfam01565 266835016895 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 266835016896 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835016897 conserved gate region; other site 266835016898 dimer interface [polypeptide binding]; other site 266835016899 putative PBP binding loops; other site 266835016900 ABC-ATPase subunit interface; other site 266835016901 ABC-type spermidine/putrescine transport system, permease component I [Amino acid transport and metabolism]; Region: PotB; COG1176 266835016902 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 266835016903 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266835016904 Walker A/P-loop; other site 266835016905 ATP binding site [chemical binding]; other site 266835016906 Q-loop/lid; other site 266835016907 ABC transporter signature motif; other site 266835016908 Walker B; other site 266835016909 D-loop; other site 266835016910 H-loop/switch region; other site 266835016911 TOBE domain; Region: TOBE_2; pfam08402 266835016912 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 266835016913 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 266835016914 Uncharacterized protein conserved in bacteria [Function unknown]; Region: GguC; COG3802 266835016915 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 266835016916 short chain dehydrogenase; Provisional; Region: PRK12939 266835016917 classical (c) SDRs; Region: SDR_c; cd05233 266835016918 NAD(P) binding site [chemical binding]; other site 266835016919 active site 266835016920 dihydroxy-acid dehydratase; Validated; Region: PRK06131 266835016921 Transcriptional regulators [Transcription]; Region: FadR; COG2186 266835016922 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266835016923 DNA-binding site [nucleotide binding]; DNA binding site 266835016924 FCD domain; Region: FCD; pfam07729 266835016925 aldose 1-epimerase, similar to Escherichia coli YphB; Region: Aldose_epim_Ec_YphB; cd09021 266835016926 active site 266835016927 catalytic residues [active] 266835016928 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 266835016929 Salicylaldehyde dehydrogenase, DoxF-like; Region: ALDH_SaliADH; cd07105 266835016930 NAD(P) binding site [chemical binding]; other site 266835016931 catalytic residues [active] 266835016932 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 266835016933 NAD(P) binding site [chemical binding]; other site 266835016934 3-alpha-hydroxysteroid dehydrogenase; Provisional; Region: PRK12428 266835016935 active site 266835016936 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 266835016937 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 266835016938 TM-ABC transporter signature motif; other site 266835016939 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 266835016940 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 266835016941 TM-ABC transporter signature motif; other site 266835016942 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 266835016943 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 266835016944 Walker A/P-loop; other site 266835016945 ATP binding site [chemical binding]; other site 266835016946 Q-loop/lid; other site 266835016947 ABC transporter signature motif; other site 266835016948 Walker B; other site 266835016949 D-loop; other site 266835016950 H-loop/switch region; other site 266835016951 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 266835016952 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 266835016953 Walker A/P-loop; other site 266835016954 ATP binding site [chemical binding]; other site 266835016955 Q-loop/lid; other site 266835016956 ABC transporter signature motif; other site 266835016957 Walker B; other site 266835016958 D-loop; other site 266835016959 H-loop/switch region; other site 266835016960 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 266835016961 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_4; cd06337 266835016962 putative ligand binding site [chemical binding]; other site 266835016963 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 266835016964 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266835016965 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266835016966 dimerization interface [polypeptide binding]; other site 266835016967 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 266835016968 4-carboxymuconolactone decarboxylase; Region: decarb_PcaC; TIGR02425 266835016969 Protocatechuate 3,4-dioxygenase (3,4-PCD) , beta subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_beta; cd03464 266835016970 heterodimer interface [polypeptide binding]; other site 266835016971 multimer interface [polypeptide binding]; other site 266835016972 protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422 266835016973 active site 266835016974 Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485 266835016975 Protocatechuate 3,4-dioxygenase (3,4-PCD) , alpha subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_alpha; cd03463 266835016976 heterodimer interface [polypeptide binding]; other site 266835016977 active site 266835016978 3-carboxy-cis,cis-muconate cycloisomerase; Provisional; Region: PRK05975 266835016979 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 266835016980 tetramer interface [polypeptide binding]; other site 266835016981 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243 266835016982 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 266835016983 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 266835016984 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835016985 dimer interface [polypeptide binding]; other site 266835016986 conserved gate region; other site 266835016987 ABC-ATPase subunit interface; other site 266835016988 Predicted tagatose 6-phosphate kinase [Carbohydrate transport and metabolism]; Region: GatZ; COG4573 266835016989 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 266835016990 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 266835016991 substrate binding site [chemical binding]; other site 266835016992 ATP binding site [chemical binding]; other site 266835016993 Transcriptional regulators [Transcription]; Region: PurR; COG1609 266835016994 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 266835016995 DNA binding site [nucleotide binding] 266835016996 domain linker motif; other site 266835016997 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 266835016998 dimerization interface [polypeptide binding]; other site 266835016999 ligand binding site [chemical binding]; other site 266835017000 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 266835017001 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 266835017002 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 266835017003 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 266835017004 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 266835017005 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 266835017006 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 266835017007 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 266835017008 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 266835017009 putative active site; other site 266835017010 catalytic residue [active] 266835017011 Ribokinase-like subgroup B. Found in bacteria and plants, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_B; cd01945 266835017012 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 266835017013 substrate binding site [chemical binding]; other site 266835017014 ATP binding site [chemical binding]; other site 266835017015 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 266835017016 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 266835017017 Walker A/P-loop; other site 266835017018 ATP binding site [chemical binding]; other site 266835017019 Q-loop/lid; other site 266835017020 ABC transporter signature motif; other site 266835017021 Walker B; other site 266835017022 D-loop; other site 266835017023 H-loop/switch region; other site 266835017024 TOBE domain; Region: TOBE_2; pfam08402 266835017025 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 266835017026 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 266835017027 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835017028 dimer interface [polypeptide binding]; other site 266835017029 conserved gate region; other site 266835017030 putative PBP binding loops; other site 266835017031 ABC-ATPase subunit interface; other site 266835017032 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 266835017033 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835017034 dimer interface [polypeptide binding]; other site 266835017035 conserved gate region; other site 266835017036 putative PBP binding loops; other site 266835017037 ABC-ATPase subunit interface; other site 266835017038 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 266835017039 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 266835017040 Metal-binding active site; metal-binding site 266835017041 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 266835017042 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 266835017043 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 266835017044 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 266835017045 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 266835017046 catalytic site [active] 266835017047 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 266835017048 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 266835017049 substrate binding site [chemical binding]; other site 266835017050 hexamer interface [polypeptide binding]; other site 266835017051 metal binding site [ion binding]; metal-binding site 266835017052 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 266835017053 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 266835017054 nucleotide binding site [chemical binding]; other site 266835017055 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 266835017056 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266835017057 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 266835017058 Q-loop/lid; other site 266835017059 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 266835017060 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 266835017061 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 266835017062 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266835017063 dimer interface [polypeptide binding]; other site 266835017064 phosphorylation site [posttranslational modification] 266835017065 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266835017066 ATP binding site [chemical binding]; other site 266835017067 Mg2+ binding site [ion binding]; other site 266835017068 G-X-G motif; other site 266835017069 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 266835017070 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266835017071 active site 266835017072 phosphorylation site [posttranslational modification] 266835017073 intermolecular recognition site; other site 266835017074 dimerization interface [polypeptide binding]; other site 266835017075 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266835017076 Walker A motif; other site 266835017077 ATP binding site [chemical binding]; other site 266835017078 Walker B motif; other site 266835017079 arginine finger; other site 266835017080 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 266835017081 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 266835017082 Coenzyme A binding pocket [chemical binding]; other site 266835017083 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 266835017084 Beta-lactamase; Region: Beta-lactamase; pfam00144 266835017085 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 266835017086 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 266835017087 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266835017088 Walker A/P-loop; other site 266835017089 ATP binding site [chemical binding]; other site 266835017090 Q-loop/lid; other site 266835017091 ABC transporter signature motif; other site 266835017092 Walker B; other site 266835017093 D-loop; other site 266835017094 H-loop/switch region; other site 266835017095 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 266835017096 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266835017097 Walker A/P-loop; other site 266835017098 ATP binding site [chemical binding]; other site 266835017099 Q-loop/lid; other site 266835017100 ABC transporter signature motif; other site 266835017101 Walker B; other site 266835017102 D-loop; other site 266835017103 H-loop/switch region; other site 266835017104 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 266835017105 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 266835017106 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835017107 putative PBP binding loops; other site 266835017108 dimer interface [polypeptide binding]; other site 266835017109 ABC-ATPase subunit interface; other site 266835017110 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 266835017111 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835017112 dimer interface [polypeptide binding]; other site 266835017113 conserved gate region; other site 266835017114 putative PBP binding loops; other site 266835017115 ABC-ATPase subunit interface; other site 266835017116 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 266835017117 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_11; cd08516 266835017118 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: PRK12570 266835017119 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 266835017120 putative active site [active] 266835017121 Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism]; Region: COG2971 266835017122 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 266835017123 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 266835017124 hinge; other site 266835017125 active site 266835017126 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 266835017127 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 266835017128 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 266835017129 putative active site [active] 266835017130 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 266835017131 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 266835017132 Transcriptional regulators [Transcription]; Region: GntR; COG1802 266835017133 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266835017134 DNA-binding site [nucleotide binding]; DNA binding site 266835017135 FCD domain; Region: FCD; pfam07729 266835017136 Cell division GTPase [Cell division and chromosome partitioning]; Region: FtsZ; COG0206 266835017137 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 266835017138 nucleotide binding site [chemical binding]; other site 266835017139 SulA interaction site; other site 266835017140 VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762 266835017141 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 266835017142 metal ion-dependent adhesion site (MIDAS); other site 266835017143 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 266835017144 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 266835017145 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 266835017146 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 266835017147 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 266835017148 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835017149 dimer interface [polypeptide binding]; other site 266835017150 conserved gate region; other site 266835017151 putative PBP binding loops; other site 266835017152 ABC-ATPase subunit interface; other site 266835017153 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 266835017154 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 266835017155 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 266835017156 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266835017157 Walker A/P-loop; other site 266835017158 ATP binding site [chemical binding]; other site 266835017159 Q-loop/lid; other site 266835017160 ABC transporter signature motif; other site 266835017161 Walker B; other site 266835017162 D-loop; other site 266835017163 H-loop/switch region; other site 266835017164 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 266835017165 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 266835017166 Walker A/P-loop; other site 266835017167 ATP binding site [chemical binding]; other site 266835017168 Q-loop/lid; other site 266835017169 ABC transporter signature motif; other site 266835017170 Walker B; other site 266835017171 D-loop; other site 266835017172 H-loop/switch region; other site 266835017173 TOBE domain; Region: TOBE_2; pfam08402 266835017174 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 266835017175 L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802 266835017176 putative N- and C-terminal domain interface [polypeptide binding]; other site 266835017177 putative active site [active] 266835017178 MgATP binding site [chemical binding]; other site 266835017179 catalytic site [active] 266835017180 metal binding site [ion binding]; metal-binding site 266835017181 putative xylulose binding site [chemical binding]; other site 266835017182 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 266835017183 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_10; cd12171 266835017184 putative ligand binding site [chemical binding]; other site 266835017185 putative NAD binding site [chemical binding]; other site 266835017186 catalytic site [active] 266835017187 glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK13369 266835017188 Uncharacterized conserved protein [Function unknown]; Region: COG3347 266835017189 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007 266835017190 Xylose isomerase [Carbohydrate transport and metabolism]; Region: XylA; cl09945 266835017191 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 266835017192 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 266835017193 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 266835017194 intersubunit interface [polypeptide binding]; other site 266835017195 active site 266835017196 zinc binding site [ion binding]; other site 266835017197 Na+ binding site [ion binding]; other site 266835017198 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266835017199 putative DNA binding site [nucleotide binding]; other site 266835017200 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 266835017201 putative Zn2+ binding site [ion binding]; other site 266835017202 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 266835017203 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 266835017204 substrate binding site [chemical binding]; other site 266835017205 dimer interface [polypeptide binding]; other site 266835017206 triosephosphate isomerase; Provisional; Region: PRK14565 266835017207 catalytic triad [active] 266835017208 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 266835017209 DAK2 domain; Region: Dak2; cl03685 266835017210 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 266835017211 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 266835017212 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-II; Region: Lumazine_synthase-II; cd09208 266835017213 active site 266835017214 homopentamer interface [polypeptide binding]; other site 266835017215 dimer interface [polypeptide binding]; other site 266835017216 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 266835017217 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 266835017218 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 266835017219 putative DNA binding site [nucleotide binding]; other site 266835017220 putative Zn2+ binding site [ion binding]; other site 266835017221 AsnC family; Region: AsnC_trans_reg; pfam01037 266835017222 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 266835017223 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182 266835017224 Phosphotransferase enzyme family; Region: APH; pfam01636 266835017225 serine/threonine protein kinase; Provisional; Region: PRK14879 266835017226 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 266835017227 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 266835017228 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 266835017229 Walker A/P-loop; other site 266835017230 ATP binding site [chemical binding]; other site 266835017231 Q-loop/lid; other site 266835017232 ABC transporter signature motif; other site 266835017233 Walker B; other site 266835017234 D-loop; other site 266835017235 H-loop/switch region; other site 266835017236 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 266835017237 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 266835017238 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 266835017239 TM-ABC transporter signature motif; other site 266835017240 Methylthioribose-binding protein-like of ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_methylthioribose_binding_like; cd06305 266835017241 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 266835017242 putative ligand binding site [chemical binding]; other site 266835017243 short chain dehydrogenase; Validated; Region: PRK08324 266835017244 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007 266835017245 active site 266835017246 Zn2+ binding site [ion binding]; other site 266835017247 intersubunit interface [polypeptide binding]; other site 266835017248 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835017249 NAD(P) binding site [chemical binding]; other site 266835017250 active site 266835017251 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 266835017252 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266835017253 sequence-specific DNA binding site [nucleotide binding]; other site 266835017254 salt bridge; other site 266835017255 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 266835017256 acyl-CoA synthetase; Validated; Region: PRK08162 266835017257 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; Region: ttLC_FACS_AEE21_like; cd12118 266835017258 acyl-activating enzyme (AAE) consensus motif; other site 266835017259 putative active site [active] 266835017260 AMP binding site [chemical binding]; other site 266835017261 putative CoA binding site [chemical binding]; other site 266835017262 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266835017263 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266835017264 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 266835017265 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 266835017266 HlyD family secretion protein; Region: HlyD_3; pfam13437 266835017267 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 266835017268 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 266835017269 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 266835017270 active site 266835017271 non-prolyl cis peptide bond; other site 266835017272 Amino acid permease; Region: AA_permease_2; pfam13520 266835017273 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 266835017274 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 266835017275 Sarcosine oxidase gamma subunit [Amino acid transport and metabolism]; Region: COG4583 266835017276 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 266835017277 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 266835017278 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 266835017279 Sarcosine oxidase delta subunit [Amino acid transport and metabolism]; Region: SoxD; COG4311 266835017280 sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373 266835017281 hydroxyglutarate oxidase; Provisional; Region: PRK11728 266835017282 glutamine synthetase, type III; Region: gln_synth_III; TIGR03105 266835017283 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 266835017284 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 266835017285 Conserved region in glutamate synthase; Region: Glu_synthase; pfam01645 266835017286 active site 266835017287 FMN binding site [chemical binding]; other site 266835017288 substrate binding site [chemical binding]; other site 266835017289 3Fe-4S cluster binding site [ion binding]; other site 266835017290 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cd00504 266835017291 domain_subunit interface; other site 266835017292 Glutamate synthase domain 1 [Amino acid transport and metabolism]; Region: GltB; COG0067 266835017293 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cd00352 266835017294 Glutamine amidotransferases class-II (Gn-AT)_GlxB-type. GlxB is a glutamine amidotransferase-like protein of unknown function found in bacteria and archaea. GlxB has a structural fold similar to that of other class II glutamine amidotransferases...; Region: GlxB; cd01907 266835017295 putative active site [active] 266835017296 ethanolamine permease; Region: 2A0305; TIGR00908 266835017297 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 266835017298 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 266835017299 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 266835017300 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 266835017301 FMN-binding pocket [chemical binding]; other site 266835017302 flavin binding motif; other site 266835017303 phosphate binding motif [ion binding]; other site 266835017304 beta-alpha-beta structure motif; other site 266835017305 NAD binding pocket [chemical binding]; other site 266835017306 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 266835017307 catalytic loop [active] 266835017308 iron binding site [ion binding]; other site 266835017309 Protein of unknown function (DUF3445); Region: DUF3445; pfam11927 266835017310 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 266835017311 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266835017312 non-specific DNA binding site [nucleotide binding]; other site 266835017313 salt bridge; other site 266835017314 sequence-specific DNA binding site [nucleotide binding]; other site 266835017315 Cupin domain; Region: Cupin_2; pfam07883 266835017316 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 266835017317 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 266835017318 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835017319 dimer interface [polypeptide binding]; other site 266835017320 conserved gate region; other site 266835017321 putative PBP binding loops; other site 266835017322 ABC-ATPase subunit interface; other site 266835017323 glycine betaine transporter membrane protein; Provisional; Region: PRK10952 266835017324 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835017325 dimer interface [polypeptide binding]; other site 266835017326 conserved gate region; other site 266835017327 ABC-ATPase subunit interface; other site 266835017328 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 266835017329 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 266835017330 Walker A/P-loop; other site 266835017331 ATP binding site [chemical binding]; other site 266835017332 Q-loop/lid; other site 266835017333 ABC transporter signature motif; other site 266835017334 Walker B; other site 266835017335 D-loop; other site 266835017336 H-loop/switch region; other site 266835017337 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 266835017338 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 266835017339 short chain dehydrogenase; Provisional; Region: PRK06114 266835017340 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835017341 NAD(P) binding site [chemical binding]; other site 266835017342 active site 266835017343 Domain of unknown function (DUF427); Region: DUF427; cl00998 266835017344 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 266835017345 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 266835017346 Methyltransferase domain; Region: Methyltransf_24; pfam13578 266835017347 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 266835017348 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 266835017349 Probable Catalytic site; other site 266835017350 metal-binding site 266835017351 Methyltransferase domain; Region: Methyltransf_23; pfam13489 266835017352 Methyltransferase domain; Region: Methyltransf_12; pfam08242 266835017353 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 266835017354 active site 266835017355 Domain of unknown function (DUF427); Region: DUF427; pfam04248 266835017356 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 266835017357 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 266835017358 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 266835017359 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 266835017360 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266835017361 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266835017362 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 266835017363 dimerization interface [polypeptide binding]; other site 266835017364 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 266835017365 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266835017366 Walker A/P-loop; other site 266835017367 ATP binding site [chemical binding]; other site 266835017368 Q-loop/lid; other site 266835017369 ABC transporter signature motif; other site 266835017370 Walker B; other site 266835017371 D-loop; other site 266835017372 H-loop/switch region; other site 266835017373 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 266835017374 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 266835017375 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266835017376 Walker A/P-loop; other site 266835017377 ATP binding site [chemical binding]; other site 266835017378 Q-loop/lid; other site 266835017379 ABC transporter signature motif; other site 266835017380 Walker B; other site 266835017381 D-loop; other site 266835017382 H-loop/switch region; other site 266835017383 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 266835017384 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 266835017385 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 266835017386 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835017387 putative PBP binding loops; other site 266835017388 dimer interface [polypeptide binding]; other site 266835017389 ABC-ATPase subunit interface; other site 266835017390 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 266835017391 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835017392 dimer interface [polypeptide binding]; other site 266835017393 conserved gate region; other site 266835017394 putative PBP binding loops; other site 266835017395 ABC-ATPase subunit interface; other site 266835017396 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 266835017397 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 266835017398 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 266835017399 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 266835017400 active site pocket [active] 266835017401 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 266835017402 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cd00308 266835017403 metal binding site [ion binding]; metal-binding site 266835017404 substrate binding pocket [chemical binding]; other site 266835017405 Transcriptional regulators [Transcription]; Region: GntR; COG1802 266835017406 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266835017407 DNA-binding site [nucleotide binding]; DNA binding site 266835017408 FCD domain; Region: FCD; pfam07729 266835017409 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266835017410 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 266835017411 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 266835017412 HlyD family secretion protein; Region: HlyD_3; pfam13437 266835017413 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 266835017414 Protein export membrane protein; Region: SecD_SecF; cl14618 266835017415 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266835017416 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266835017417 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 266835017418 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 266835017419 DNA binding site [nucleotide binding] 266835017420 Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307 266835017421 putative ligand binding site [chemical binding]; other site 266835017422 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 266835017423 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 266835017424 Walker A/P-loop; other site 266835017425 ATP binding site [chemical binding]; other site 266835017426 Q-loop/lid; other site 266835017427 ABC transporter signature motif; other site 266835017428 Walker B; other site 266835017429 D-loop; other site 266835017430 H-loop/switch region; other site 266835017431 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 266835017432 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 266835017433 TM-ABC transporter signature motif; other site 266835017434 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 266835017435 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312 266835017436 putative ligand binding site [chemical binding]; other site 266835017437 Fumarylacetoacetate (FAA) hydrolase family protein [General function prediction only]; Region: COG3970 266835017438 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 266835017439 aldose 1-epimerase, similar to Escherichia coli YphB; Region: Aldose_epim_Ec_YphB; cd09021 266835017440 active site 266835017441 catalytic residues [active] 266835017442 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 266835017443 classical (c) SDRs; Region: SDR_c; cd05233 266835017444 NAD(P) binding site [chemical binding]; other site 266835017445 active site 266835017446 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 266835017447 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266835017448 Walker A/P-loop; other site 266835017449 ATP binding site [chemical binding]; other site 266835017450 Q-loop/lid; other site 266835017451 ABC transporter signature motif; other site 266835017452 Walker B; other site 266835017453 D-loop; other site 266835017454 H-loop/switch region; other site 266835017455 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 266835017456 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 266835017457 TM-ABC transporter signature motif; other site 266835017458 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 266835017459 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312 266835017460 putative ligand binding site [chemical binding]; other site 266835017461 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 266835017462 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 266835017463 active site pocket [active] 266835017464 Transcriptional regulators [Transcription]; Region: FadR; COG2186 266835017465 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266835017466 DNA-binding site [nucleotide binding]; DNA binding site 266835017467 FCD domain; Region: FCD; pfam07729 266835017468 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 266835017469 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 266835017470 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835017471 dimer interface [polypeptide binding]; other site 266835017472 conserved gate region; other site 266835017473 putative PBP binding loops; other site 266835017474 ABC-ATPase subunit interface; other site 266835017475 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 266835017476 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835017477 putative PBP binding loops; other site 266835017478 dimer interface [polypeptide binding]; other site 266835017479 ABC-ATPase subunit interface; other site 266835017480 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 266835017481 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 266835017482 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266835017483 sequence-specific DNA binding site [nucleotide binding]; other site 266835017484 salt bridge; other site 266835017485 Cupin domain; Region: Cupin_2; pfam07883 266835017486 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 266835017487 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266835017488 Walker A/P-loop; other site 266835017489 ATP binding site [chemical binding]; other site 266835017490 Q-loop/lid; other site 266835017491 ABC transporter signature motif; other site 266835017492 Walker B; other site 266835017493 D-loop; other site 266835017494 H-loop/switch region; other site 266835017495 TOBE domain; Region: TOBE_2; pfam08402 266835017496 Uncharacterized conserved protein [Function unknown]; Region: COG2135 266835017497 SnoaL-like domain; Region: SnoaL_2; pfam12680 266835017498 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 266835017499 ArsC family; Region: ArsC; pfam03960 266835017500 putative catalytic residues [active] 266835017501 Uncharacterized conserved protein [Function unknown]; Region: COG3189 266835017502 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 266835017503 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 266835017504 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 266835017505 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266835017506 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 266835017507 dimerization interface [polypeptide binding]; other site 266835017508 substrate binding pocket [chemical binding]; other site 266835017509 Protein of unknown function (DUF1228); Region: DUF1228; pfam06779 266835017510 D-galactonate transporter; Region: 2A0114; TIGR00893 266835017511 microcin B17 transporter; Reviewed; Region: PRK11098 266835017512 Putative catalytic domain of uncharacterized bacterial hypothetical proteins similar to insect chitin deacetylase-like proteins; Region: CE4_CDA_like_3; cd10976 266835017513 NodB motif; other site 266835017514 putative active site [active] 266835017515 putative catalytic site [active] 266835017516 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4649 266835017517 Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976 266835017518 GTP-binding protein Der; Reviewed; Region: PRK00093 266835017519 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 266835017520 G1 box; other site 266835017521 GTP/Mg2+ binding site [chemical binding]; other site 266835017522 Switch I region; other site 266835017523 G2 box; other site 266835017524 Switch II region; other site 266835017525 G3 box; other site 266835017526 G4 box; other site 266835017527 G5 box; other site 266835017528 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 266835017529 G1 box; other site 266835017530 GTP/Mg2+ binding site [chemical binding]; other site 266835017531 Switch I region; other site 266835017532 G2 box; other site 266835017533 G3 box; other site 266835017534 Switch II region; other site 266835017535 G4 box; other site 266835017536 G5 box; other site 266835017537 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266835017538 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266835017539 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266835017540 dimerization interface [polypeptide binding]; other site 266835017541 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266835017542 putative substrate translocation pore; other site 266835017543 Major Facilitator Superfamily; Region: MFS_1; pfam07690 266835017544 Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773 266835017545 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 266835017546 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5336 266835017547 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 266835017548 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 266835017549 F0F1 ATP synthase subunit C; Validated; Region: PRK07558 266835017550 F0F1 ATP synthase subunit B'; Validated; Region: PRK09174 266835017551 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 266835017552 F0F1 ATP synthase subunit B; Validated; Region: PRK09173 266835017553 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 266835017554 RNA/DNA hybrid binding site [nucleotide binding]; other site 266835017555 active site 266835017556 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 266835017557 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 266835017558 FeS/SAM binding site; other site 266835017559 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 266835017560 MPT binding site; other site 266835017561 trimer interface [polypeptide binding]; other site 266835017562 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14608 266835017563 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 266835017564 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 266835017565 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 266835017566 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 266835017567 tandem repeat interface [polypeptide binding]; other site 266835017568 oligomer interface [polypeptide binding]; other site 266835017569 active site residues [active] 266835017570 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 266835017571 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266835017572 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 266835017573 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 266835017574 substrate binding pocket [chemical binding]; other site 266835017575 chain length determination region; other site 266835017576 substrate-Mg2+ binding site; other site 266835017577 catalytic residues [active] 266835017578 aspartate-rich region 1; other site 266835017579 active site lid residues [active] 266835017580 aspartate-rich region 2; other site 266835017581 Transcriptional regulators [Transcription]; Region: GntR; COG1802 266835017582 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266835017583 DNA-binding site [nucleotide binding]; DNA binding site 266835017584 FCD domain; Region: FCD; pfam07729 266835017585 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 266835017586 Uncharacterized conserved protein [Function unknown]; Region: COG3543 266835017587 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266835017588 TPR motif; other site 266835017589 binding surface 266835017590 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266835017591 binding surface 266835017592 TPR motif; other site 266835017593 TPR repeat; Region: TPR_11; pfam13414 266835017594 TPR repeat; Region: TPR_11; pfam13414 266835017595 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266835017596 binding surface 266835017597 TPR motif; other site 266835017598 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 266835017599 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 266835017600 Coenzyme A binding pocket [chemical binding]; other site 266835017601 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 266835017602 dimer interface [polypeptide binding]; other site 266835017603 motif 1; other site 266835017604 active site 266835017605 motif 2; other site 266835017606 motif 3; other site 266835017607 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 266835017608 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 266835017609 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 266835017610 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 266835017611 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 266835017612 FAD binding domain; Region: FAD_binding_4; pfam01565 266835017613 4-hydroxybenzoate polyprenyltransferase; Reviewed; Region: ubiA; PRK12878 266835017614 UbiA prenyltransferase family; Region: UbiA; pfam01040 266835017615 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266835017616 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266835017617 The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412 266835017618 putative substrate binding pocket [chemical binding]; other site 266835017619 dimerization interface [polypeptide binding]; other site 266835017620 Protein involved in biosynthesis of mitomycin antibiotics/polyketide fumonisin [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG5285 266835017621 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 266835017622 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 266835017623 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 266835017624 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 266835017625 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cd00599 266835017626 active site 266835017627 Lyzozyme M1 (1,4-beta-N-acetylmuramidase) [Cell envelope biogenesis, outer membrane]; Region: Acm; COG3757 266835017628 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 266835017629 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 266835017630 active site 266835017631 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 266835017632 enoyl-CoA hydratase; Provisional; Region: PRK06688 266835017633 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266835017634 substrate binding site [chemical binding]; other site 266835017635 oxyanion hole (OAH) forming residues; other site 266835017636 trimer interface [polypeptide binding]; other site 266835017637 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 266835017638 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 266835017639 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 266835017640 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 266835017641 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 266835017642 HSP70 interaction site [polypeptide binding]; other site 266835017643 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 266835017644 substrate binding site [polypeptide binding]; other site 266835017645 dimer interface [polypeptide binding]; other site 266835017646 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08159 266835017647 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 266835017648 NAD binding site [chemical binding]; other site 266835017649 homotetramer interface [polypeptide binding]; other site 266835017650 homodimer interface [polypeptide binding]; other site 266835017651 substrate binding site [chemical binding]; other site 266835017652 active site 266835017653 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 266835017654 catalytic core [active] 266835017655 Protein of unknown function (DUF1344); Region: DUF1344; pfam07076 266835017656 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 266835017657 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 266835017658 Tetramer interface [polypeptide binding]; other site 266835017659 active site 266835017660 FMN-binding site [chemical binding]; other site 266835017661 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 266835017662 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 266835017663 GTP cyclohydrolase II [Coenzyme metabolism]; Region: RibA; COG0807 266835017664 dimerization interface [polypeptide binding]; other site 266835017665 active site 266835017666 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 266835017667 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 266835017668 Coenzyme A binding pocket [chemical binding]; other site 266835017669 Major Facilitator Superfamily; Region: MFS_1; pfam07690 266835017670 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266835017671 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266835017672 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145 266835017673 putative FMN binding site [chemical binding]; other site 266835017674 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 266835017675 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_2; cd11599 266835017676 putative active site [active] 266835017677 Zn binding site [ion binding]; other site 266835017678 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 266835017679 Uncharacterized conserved protein [Function unknown]; Region: COG5552 266835017680 Pirin-related protein [General function prediction only]; Region: COG1741 266835017681 Pirin; Region: Pirin; pfam02678 266835017682 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 266835017683 Deoxyxylulose-5-phosphate synthase [Coenzyme metabolism / Lipid metabolism]; Region: Dxs; COG1154 266835017684 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 266835017685 TPP-binding site; other site 266835017686 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 266835017687 PYR/PP interface [polypeptide binding]; other site 266835017688 dimer interface [polypeptide binding]; other site 266835017689 TPP binding site [chemical binding]; other site 266835017690 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 266835017691 Uncharacterized conserved protein [Function unknown]; Region: COG3791 266835017692 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 266835017693 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 266835017694 RNA binding surface [nucleotide binding]; other site 266835017695 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266835017696 S-adenosylmethionine binding site [chemical binding]; other site 266835017697 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 266835017698 Methyltransferase domain; Region: Methyltransf_26; pfam13659 266835017699 S-adenosylmethionine binding site [chemical binding]; other site 266835017700 Uncharacterized protein containing caspase domain [General function prediction only]; Region: COG4249 266835017701 Caspase domain; Region: Peptidase_C14; pfam00656 266835017702 Bacterial transglutaminase-like cysteine proteinase BTLCP; Region: BTLCP; pfam06035 266835017703 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 266835017704 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 266835017705 protease TldD; Provisional; Region: tldD; PRK10735 266835017706 Invasion protein B, involved in pathogenesis [General function prediction only]; Region: COG5342 266835017707 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 266835017708 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 266835017709 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 266835017710 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 266835017711 Cytochrome C oxidase subunit I. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663 266835017712 Subunit I/III interface [polypeptide binding]; other site 266835017713 D-pathway; other site 266835017714 Subunit I/VIIc interface [polypeptide binding]; other site 266835017715 Subunit I/IV interface [polypeptide binding]; other site 266835017716 Subunit I/II interface [polypeptide binding]; other site 266835017717 Low-spin heme (heme a) binding site [chemical binding]; other site 266835017718 Subunit I/VIIa interface [polypeptide binding]; other site 266835017719 Subunit I/VIa interface [polypeptide binding]; other site 266835017720 Dimer interface; other site 266835017721 Putative water exit pathway; other site 266835017722 Binuclear center (heme a3/CuB) [ion binding]; other site 266835017723 K-pathway; other site 266835017724 Subunit I/Vb interface [polypeptide binding]; other site 266835017725 Putative proton exit pathway; other site 266835017726 Subunit I/VIb interface; other site 266835017727 Subunit I/VIc interface [polypeptide binding]; other site 266835017728 Electron transfer pathway; other site 266835017729 Subunit I/VIIIb interface [polypeptide binding]; other site 266835017730 Subunit I/VIIb interface [polypeptide binding]; other site 266835017731 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 266835017732 UbiA prenyltransferase family; Region: UbiA; pfam01040 266835017733 Cytochrome oxidase assembly factor [Posttranslational modification, protein turnover, chaperones]; Region: COX11; COG3175 266835017734 Cytochrome c oxidase subunit III. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665 266835017735 Subunit III/VIIa interface [polypeptide binding]; other site 266835017736 Phospholipid binding site [chemical binding]; other site 266835017737 Subunit I/III interface [polypeptide binding]; other site 266835017738 Subunit III/VIb interface [polypeptide binding]; other site 266835017739 Subunit III/VIa interface; other site 266835017740 Subunit III/Vb interface [polypeptide binding]; other site 266835017741 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 266835017742 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 266835017743 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5349 266835017744 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 266835017745 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 266835017746 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 266835017747 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 266835017748 Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153 266835017749 putative active site [active] 266835017750 putative substrate binding site [chemical binding]; other site 266835017751 ATP binding site [chemical binding]; other site 266835017752 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 266835017753 RNA/DNA hybrid binding site [nucleotide binding]; other site 266835017754 active site 266835017755 Broad specificity phosphatase PhoE and related phosphatases [General function prediction only]; Region: phoE; COG0406 266835017756 catalytic core [active] 266835017757 Protein of unknown function (DUF2938); Region: DUF2938; pfam11158 266835017758 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 266835017759 catalytic triad [active] 266835017760 dimer interface [polypeptide binding]; other site 266835017761 Uncharacterized protein predicted to be involved in C-type cytochrome biogenesis [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4233 266835017762 hypothetical protein; Validated; Region: PRK00228 266835017763 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266835017764 PAS fold; Region: PAS_3; pfam08447 266835017765 putative active site [active] 266835017766 heme pocket [chemical binding]; other site 266835017767 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 266835017768 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266835017769 metal binding site [ion binding]; metal-binding site 266835017770 active site 266835017771 I-site; other site 266835017772 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 266835017773 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 266835017774 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 266835017775 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 266835017776 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 266835017777 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 266835017778 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 266835017779 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 266835017780 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266835017781 catalytic residue [active] 266835017782 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 266835017783 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 266835017784 motif II; other site 266835017785 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 266835017786 DNA methylase; Region: N6_N4_Mtase; pfam01555 266835017787 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 266835017788 ?-D-glucose-1-phosphatase; Provisional; Region: PRK09456 266835017789 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 266835017790 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 266835017791 minor groove reading motif; other site 266835017792 helix-hairpin-helix signature motif; other site 266835017793 substrate binding pocket [chemical binding]; other site 266835017794 active site 266835017795 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 266835017796 DNA binding and oxoG recognition site [nucleotide binding] 266835017797 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5389 266835017798 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 266835017799 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 266835017800 catalytic residues [active] 266835017801 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 266835017802 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 266835017803 Walker A/P-loop; other site 266835017804 ATP binding site [chemical binding]; other site 266835017805 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; cl05797 266835017806 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 266835017807 ABC transporter signature motif; other site 266835017808 Walker B; other site 266835017809 D-loop; other site 266835017810 H-loop/switch region; other site 266835017811 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266835017812 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 266835017813 pyruvate phosphate dikinase; Provisional; Region: PRK09279 266835017814 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 266835017815 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 266835017816 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 266835017817 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 266835017818 Putative catalytic NodB homology domain of uncharacterized BH0857 protein from Bacillus halodurans and its bacterial homologs; Region: CE4_BH0857_like; cd10955 266835017819 NodB motif; other site 266835017820 putative active site [active] 266835017821 putative catalytic site [active] 266835017822 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 266835017823 putative acyl-CoA synthetase; Provisional; Region: PRK06018 266835017824 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 266835017825 dimer interface [polypeptide binding]; other site 266835017826 acyl-activating enzyme (AAE) consensus motif; other site 266835017827 putative active site [active] 266835017828 AMP binding site [chemical binding]; other site 266835017829 putative CoA binding site [chemical binding]; other site 266835017830 Protein of unknown function (DUF1499); Region: DUF1499; pfam07386 266835017831 Transcriptional regulators [Transcription]; Region: PurR; COG1609 266835017832 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 266835017833 DNA binding site [nucleotide binding] 266835017834 domain linker motif; other site 266835017835 Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271 266835017836 ligand binding site [chemical binding]; other site 266835017837 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 266835017838 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 266835017839 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 266835017840 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266835017841 Walker A/P-loop; other site 266835017842 ATP binding site [chemical binding]; other site 266835017843 Q-loop/lid; other site 266835017844 ABC transporter signature motif; other site 266835017845 Walker B; other site 266835017846 D-loop; other site 266835017847 H-loop/switch region; other site 266835017848 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835017849 dimer interface [polypeptide binding]; other site 266835017850 conserved gate region; other site 266835017851 putative PBP binding loops; other site 266835017852 ABC-ATPase subunit interface; other site 266835017853 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 266835017854 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 266835017855 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835017856 dimer interface [polypeptide binding]; other site 266835017857 conserved gate region; other site 266835017858 putative PBP binding loops; other site 266835017859 ABC-ATPase subunit interface; other site 266835017860 Purine nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pnp; COG0005 266835017861 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 266835017862 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 266835017863 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 266835017864 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 266835017865 putative NAD(P) binding site [chemical binding]; other site 266835017866 active site 266835017867 putative substrate binding site [chemical binding]; other site 266835017868 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 266835017869 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 266835017870 substrate binding site; other site 266835017871 tetramer interface; other site 266835017872 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 266835017873 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 266835017874 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 266835017875 NAD binding site [chemical binding]; other site 266835017876 substrate binding site [chemical binding]; other site 266835017877 homodimer interface [polypeptide binding]; other site 266835017878 active site 266835017879 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 266835017880 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 266835017881 NADP binding site [chemical binding]; other site 266835017882 active site 266835017883 putative substrate binding site [chemical binding]; other site 266835017884 Methyltransferase domain; Region: Methyltransf_24; pfam13578 266835017885 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 266835017886 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 266835017887 Ligand binding site; other site 266835017888 Putative Catalytic site; other site 266835017889 DXD motif; other site 266835017890 Predicted integral membrane protein [Function unknown]; Region: COG0392 266835017891 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 266835017892 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835017893 NAD(P) binding site [chemical binding]; other site 266835017894 active site 266835017895 Rhamnan synthesis protein F; Region: RgpF; pfam05045 266835017896 Rhamnan synthesis protein F; Region: RgpF; pfam05045 266835017897 Rhamnan synthesis protein F; Region: RgpF; pfam05045 266835017898 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3551 266835017899 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 266835017900 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 266835017901 Walker A/P-loop; other site 266835017902 ATP binding site [chemical binding]; other site 266835017903 Q-loop/lid; other site 266835017904 ABC transporter signature motif; other site 266835017905 Walker B; other site 266835017906 D-loop; other site 266835017907 H-loop/switch region; other site 266835017908 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 266835017909 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196 266835017910 Probable Catalytic site; other site 266835017911 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 266835017912 ManB is a bacterial phosphomannomutase (PMM) that catalyzes the conversion of mannose 6-phosphate to mannose-1-phosphate in the second of three steps in the GDP-mannose pathway, in which GDP-D-mannose is synthesized from fructose-6-phosphate. In...; Region: ManB; cd03088 266835017913 active site 266835017914 substrate binding site [chemical binding]; other site 266835017915 metal binding site [ion binding]; metal-binding site 266835017916 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 266835017917 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 266835017918 NAD(P) binding site [chemical binding]; other site 266835017919 homodimer interface [polypeptide binding]; other site 266835017920 substrate binding site [chemical binding]; other site 266835017921 active site 266835017922 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 266835017923 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 266835017924 UDP-glucose 4 epimerase, subgroup 4, extended (e) SDRs; Region: UDP_G4E_4_SDR_e; cd05232 266835017925 putative NAD(P) binding site [chemical binding]; other site 266835017926 active site 266835017927 putative substrate binding site [chemical binding]; other site 266835017928 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 266835017929 O-Antigen ligase; Region: Wzy_C; pfam04932 266835017930 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 266835017931 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 266835017932 Active Sites [active] 266835017933 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506 266835017934 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 266835017935 CysD dimerization site [polypeptide binding]; other site 266835017936 G1 box; other site 266835017937 putative GEF interaction site [polypeptide binding]; other site 266835017938 GTP/Mg2+ binding site [chemical binding]; other site 266835017939 Switch I region; other site 266835017940 G2 box; other site 266835017941 G3 box; other site 266835017942 Switch II region; other site 266835017943 G4 box; other site 266835017944 G5 box; other site 266835017945 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 266835017946 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 266835017947 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 266835017948 ligand-binding site [chemical binding]; other site 266835017949 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 266835017950 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 266835017951 active site 266835017952 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 266835017953 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 266835017954 inhibitor-cofactor binding pocket; inhibition site 266835017955 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266835017956 catalytic residue [active] 266835017957 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 266835017958 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 266835017959 putative substrate binding site [chemical binding]; other site 266835017960 putative ATP binding site [chemical binding]; other site 266835017961 Fucose dissimilation pathway protein FucU [Carbohydrate transport and metabolism]; Region: FucU; COG4154 266835017962 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 266835017963 DNA binding site [nucleotide binding] 266835017964 sequence specific DNA binding site [nucleotide binding]; other site 266835017965 putative cAMP binding site [chemical binding]; other site 266835017966 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 266835017967 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 266835017968 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 266835017969 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 266835017970 ligand binding site [chemical binding]; other site 266835017971 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 266835017972 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 266835017973 TM-ABC transporter signature motif; other site 266835017974 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 266835017975 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266835017976 Walker A/P-loop; other site 266835017977 ATP binding site [chemical binding]; other site 266835017978 Q-loop/lid; other site 266835017979 ABC transporter signature motif; other site 266835017980 Walker B; other site 266835017981 D-loop; other site 266835017982 H-loop/switch region; other site 266835017983 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 266835017984 homodimer interface [polypeptide binding]; other site 266835017985 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 266835017986 active site pocket [active] 266835017987 glycogen branching enzyme; Provisional; Region: PRK05402 266835017988 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 266835017989 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 266835017990 active site 266835017991 catalytic site [active] 266835017992 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 266835017993 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 266835017994 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 266835017995 ligand binding site; other site 266835017996 oligomer interface; other site 266835017997 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 266835017998 dimer interface [polypeptide binding]; other site 266835017999 N-terminal domain interface [polypeptide binding]; other site 266835018000 sulfate 1 binding site; other site 266835018001 glycogen synthase; Provisional; Region: glgA; PRK00654 266835018002 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 266835018003 ADP-binding pocket [chemical binding]; other site 266835018004 homodimer interface [polypeptide binding]; other site 266835018005 phosphoglucomutase; Region: PLN02307 266835018006 Phosphoglucomutase 1 (PGM1) catalyzes the bidirectional interconversion of glucose-1-phosphate (G-1-P) and glucose-6-phosphate (G-6-P) via a glucose 1,6-diphosphate intermediate, an important metabolic step in prokaryotes and eukaryotes. In one direction; Region: PGM1; cd03085 266835018007 substrate binding site [chemical binding]; other site 266835018008 dimer interface [polypeptide binding]; other site 266835018009 active site 266835018010 metal binding site [ion binding]; metal-binding site 266835018011 Type II secretory pathway, pullulanase PulA and related glycosidases [Carbohydrate transport and metabolism]; Region: PulA; COG1523 266835018012 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 266835018013 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 266835018014 active site 266835018015 catalytic site [active] 266835018016 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase) and related proteins; Region: AmyAc_OligoGlu; cd11330 266835018017 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 266835018018 active site 266835018019 catalytic site [active] 266835018020 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706 266835018021 Predicted membrane protein [Function unknown]; Region: COG4655 266835018022 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 266835018023 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 266835018024 peptide binding site [polypeptide binding]; other site 266835018025 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 266835018026 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 266835018027 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835018028 dimer interface [polypeptide binding]; other site 266835018029 conserved gate region; other site 266835018030 putative PBP binding loops; other site 266835018031 ABC-ATPase subunit interface; other site 266835018032 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 266835018033 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 266835018034 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835018035 dimer interface [polypeptide binding]; other site 266835018036 conserved gate region; other site 266835018037 putative PBP binding loops; other site 266835018038 ABC-ATPase subunit interface; other site 266835018039 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 266835018040 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266835018041 Walker A/P-loop; other site 266835018042 ATP binding site [chemical binding]; other site 266835018043 Q-loop/lid; other site 266835018044 ABC transporter signature motif; other site 266835018045 Walker B; other site 266835018046 D-loop; other site 266835018047 H-loop/switch region; other site 266835018048 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 266835018049 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266835018050 Walker A/P-loop; other site 266835018051 ATP binding site [chemical binding]; other site 266835018052 Q-loop/lid; other site 266835018053 ABC transporter signature motif; other site 266835018054 Walker B; other site 266835018055 D-loop; other site 266835018056 H-loop/switch region; other site 266835018057 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 266835018058 NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251 266835018059 NmrA-like family; Region: NmrA; pfam05368 266835018060 NADP binding site [chemical binding]; other site 266835018061 active site 266835018062 regulatory binding site [polypeptide binding]; other site 266835018063 LysR family transcriptional regulator; Provisional; Region: PRK14997 266835018064 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266835018065 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 266835018066 putative effector binding pocket; other site 266835018067 dimerization interface [polypeptide binding]; other site 266835018068 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 266835018069 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 266835018070 Substrate binding site; other site 266835018071 Cupin domain; Region: Cupin_2; cl17218 266835018072 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249 266835018073 dimerization interface [polypeptide binding]; other site 266835018074 putative active cleft [active] 266835018075 betaine aldehyde dehydrogenase; Provisional; Region: PRK13252 266835018076 NAD+-dependent 4-trimethylaminobutyraldehyde dehydrogenase, ALDH family 9A1; Region: ALDH_F9_TMBADH; cd07090 266835018077 tetrameric interface [polypeptide binding]; other site 266835018078 NAD binding site [chemical binding]; other site 266835018079 catalytic residues [active] 266835018080 choline dehydrogenase; Validated; Region: PRK02106 266835018081 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 266835018082 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 266835018083 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 266835018084 tetramer interface [polypeptide binding]; other site 266835018085 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266835018086 catalytic residue [active] 266835018087 choline-sulfatase; Region: chol_sulfatase; TIGR03417 266835018088 Sulfatase; Region: Sulfatase; cl17466 266835018089 Choline sulfatase enzyme C terminal; Region: Choline_sulf_C; pfam12411 266835018090 transcriptional regulator BetI; Validated; Region: PRK00767 266835018091 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266835018092 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 266835018093 acetyl-CoA acetyltransferase; Provisional; Region: PRK07516 266835018094 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 266835018095 active site 266835018096 L-asparaginase II [Amino acid transport and metabolism]; Region: AnsA; COG4448 266835018097 twin-arg-translocated uncharacterized repeat protein; Region: RR_plus_rpt_1; TIGR03808 266835018098 transcription elongation factor regulatory protein; Validated; Region: PRK06342 266835018099 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 266835018100 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 266835018101 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 266835018102 active site 266835018103 substrate binding site [chemical binding]; other site 266835018104 coenzyme B12 binding site [chemical binding]; other site 266835018105 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 266835018106 B12 binding site [chemical binding]; other site 266835018107 cobalt ligand [ion binding]; other site 266835018108 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 266835018109 heterodimer interface [polypeptide binding]; other site 266835018110 substrate interaction site [chemical binding]; other site 266835018111 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 266835018112 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 266835018113 motif II; other site 266835018114 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 266835018115 DNA binding site [nucleotide binding] 266835018116 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 266835018117 Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307 266835018118 putative ligand binding site [chemical binding]; other site 266835018119 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 266835018120 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 266835018121 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 266835018122 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312 266835018123 putative ligand binding site [chemical binding]; other site 266835018124 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 266835018125 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 266835018126 TM-ABC transporter signature motif; other site 266835018127 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 266835018128 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 266835018129 Walker A/P-loop; other site 266835018130 ATP binding site [chemical binding]; other site 266835018131 Q-loop/lid; other site 266835018132 ABC transporter signature motif; other site 266835018133 Walker B; other site 266835018134 D-loop; other site 266835018135 H-loop/switch region; other site 266835018136 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 266835018137 [2Fe-2S] cluster binding site [ion binding]; other site 266835018138 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 266835018139 Ketopantoate hydroxymethyltransferase [Coenzyme metabolism]; Region: PanB; COG0413 266835018140 oligomerization interface [polypeptide binding]; other site 266835018141 active site 266835018142 metal binding site [ion binding]; metal-binding site 266835018143 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 266835018144 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 266835018145 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 266835018146 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 266835018147 motif II; other site 266835018148 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 266835018149 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 266835018150 homodimer interface [polypeptide binding]; other site 266835018151 substrate-cofactor binding pocket; other site 266835018152 catalytic residue [active] 266835018153 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 266835018154 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 266835018155 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 266835018156 Cytochrome c556 [Energy production and conversion]; Region: COG3909 266835018157 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 266835018158 Proteins containing SET domain [General function prediction only]; Region: COG2940 266835018159 SET domain; Region: SET; pfam00856 266835018160 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 266835018161 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 266835018162 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 266835018163 Predicted transcriptional regulator [Transcription]; Region: COG4957 266835018164 Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166 266835018165 nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073 266835018166 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266835018167 putative active site [active] 266835018168 heme pocket [chemical binding]; other site 266835018169 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266835018170 dimer interface [polypeptide binding]; other site 266835018171 phosphorylation site [posttranslational modification] 266835018172 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266835018173 ATP binding site [chemical binding]; other site 266835018174 Mg2+ binding site [ion binding]; other site 266835018175 G-X-G motif; other site 266835018176 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 266835018177 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 266835018178 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 266835018179 Uncharacterized conserved protein [Function unknown]; Region: COG5447 266835018180 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5330 266835018181 Uncharacterized protein conserved in bacteria (DUF2336); Region: DUF2336; pfam10098 266835018182 Predicted integral membrane protein [Function unknown]; Region: COG5436 266835018183 Uncharacterized conserved protein [Function unknown]; Region: COG5402 266835018184 Transglycosylase; Region: Transgly; pfam00912 266835018185 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 266835018186 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 266835018187 allantoate amidohydrolase; Reviewed; Region: PRK12893 266835018188 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 266835018189 active site 266835018190 metal binding site [ion binding]; metal-binding site 266835018191 dimer interface [polypeptide binding]; other site 266835018192 Predicted TIM-barrel enzyme [General function prediction only]; Region: SgcQ; COG0434 266835018193 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 266835018194 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 266835018195 substrate binding site [chemical binding]; other site 266835018196 dimer interface [polypeptide binding]; other site 266835018197 ATP binding site [chemical binding]; other site 266835018198 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 266835018199 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 266835018200 active site 266835018201 substrate binding pocket [chemical binding]; other site 266835018202 homodimer interaction site [polypeptide binding]; other site 266835018203 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 266835018204 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 266835018205 TM-ABC transporter signature motif; other site 266835018206 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 266835018207 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 266835018208 Walker A/P-loop; other site 266835018209 ATP binding site [chemical binding]; other site 266835018210 Q-loop/lid; other site 266835018211 ABC transporter signature motif; other site 266835018212 Walker B; other site 266835018213 D-loop; other site 266835018214 H-loop/switch region; other site 266835018215 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 266835018216 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 266835018217 ligand binding site [chemical binding]; other site 266835018218 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 266835018219 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266835018220 non-specific DNA binding site [nucleotide binding]; other site 266835018221 salt bridge; other site 266835018222 sequence-specific DNA binding site [nucleotide binding]; other site 266835018223 Cupin domain; Region: Cupin_2; pfam07883 266835018224 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 266835018225 Amidinotransferase; Region: Amidinotransf; pfam02274 266835018226 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 266835018227 amidohydrolase; Region: amidohydrolases; TIGR01891 266835018228 metal binding site [ion binding]; metal-binding site 266835018229 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 266835018230 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266835018231 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 266835018232 dimerization interface [polypeptide binding]; other site 266835018233 substrate binding pocket [chemical binding]; other site 266835018234 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 266835018235 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266835018236 Walker A/P-loop; other site 266835018237 ATP binding site [chemical binding]; other site 266835018238 Q-loop/lid; other site 266835018239 ABC transporter signature motif; other site 266835018240 Walker B; other site 266835018241 D-loop; other site 266835018242 H-loop/switch region; other site 266835018243 TOBE domain; Region: TOBE_2; pfam08402 266835018244 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 266835018245 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 266835018246 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835018247 dimer interface [polypeptide binding]; other site 266835018248 ABC-ATPase subunit interface; other site 266835018249 putative PBP binding loops; other site 266835018250 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 266835018251 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835018252 dimer interface [polypeptide binding]; other site 266835018253 conserved gate region; other site 266835018254 putative PBP binding loops; other site 266835018255 ABC-ATPase subunit interface; other site 266835018256 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 266835018257 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835018258 NAD(P) binding site [chemical binding]; other site 266835018259 active site 266835018260 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 266835018261 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266835018262 active site 266835018263 phosphorylation site [posttranslational modification] 266835018264 intermolecular recognition site; other site 266835018265 dimerization interface [polypeptide binding]; other site 266835018266 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266835018267 DNA binding site [nucleotide binding] 266835018268 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 266835018269 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266835018270 ATP binding site [chemical binding]; other site 266835018271 G-X-G motif; other site 266835018272 Surface antigen [Cell envelope biogenesis, outer membrane]; Region: LipA; COG4520 266835018273 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 266835018274 cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142 266835018275 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266835018276 binding surface 266835018277 TPR motif; other site 266835018278 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13254 266835018279 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138 266835018280 Uncharacterized protein involved in biosynthesis of c-type cytochromes [Posttranslational modification, protein turnover, chaperones]; Region: CcmH; COG3088 266835018281 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 266835018282 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 266835018283 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 266835018284 protein binding site [polypeptide binding]; other site 266835018285 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 266835018286 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 266835018287 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266835018288 active site 266835018289 phosphorylation site [posttranslational modification] 266835018290 intermolecular recognition site; other site 266835018291 dimerization interface [polypeptide binding]; other site 266835018292 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266835018293 DNA binding site [nucleotide binding] 266835018294 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 266835018295 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 266835018296 dimerization interface [polypeptide binding]; other site 266835018297 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266835018298 dimer interface [polypeptide binding]; other site 266835018299 phosphorylation site [posttranslational modification] 266835018300 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266835018301 ATP binding site [chemical binding]; other site 266835018302 Mg2+ binding site [ion binding]; other site 266835018303 G-X-G motif; other site 266835018304 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14108 266835018305 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 266835018306 metal binding triad; other site 266835018307 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 266835018308 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 266835018309 metal binding triad; other site 266835018310 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 266835018311 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 266835018312 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266835018313 dimer interface [polypeptide binding]; other site 266835018314 phosphorylation site [posttranslational modification] 266835018315 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266835018316 ATP binding site [chemical binding]; other site 266835018317 Mg2+ binding site [ion binding]; other site 266835018318 G-X-G motif; other site 266835018319 aminopeptidase N; Provisional; Region: pepN; PRK14015 266835018320 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 266835018321 active site 266835018322 Zn binding site [ion binding]; other site 266835018323 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 266835018324 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 266835018325 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 266835018326 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 266835018327 EamA-like transporter family; Region: EamA; pfam00892 266835018328 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 266835018329 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266835018330 non-specific DNA binding site [nucleotide binding]; other site 266835018331 salt bridge; other site 266835018332 sequence-specific DNA binding site [nucleotide binding]; other site 266835018333 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 266835018334 Fe-S cluster binding site [ion binding]; other site 266835018335 active site 266835018336 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 266835018337 hydroxyglutarate oxidase; Provisional; Region: PRK11728 266835018338 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 266835018339 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 266835018340 Predicted secreted Zn-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5664 266835018341 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3021 266835018342 putative catalytic site [active] 266835018343 putative metal binding site [ion binding]; other site 266835018344 putative phosphate binding site [ion binding]; other site 266835018345 AMP nucleosidase; Provisional; Region: PRK08292 266835018346 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 266835018347 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 266835018348 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4731 266835018349 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 266835018350 Sel1 repeat; Region: Sel1; cl02723 266835018351 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 266835018352 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 266835018353 dimerization interface [polypeptide binding]; other site 266835018354 ligand binding site [chemical binding]; other site 266835018355 Spore Coat Protein U domain; Region: SCPU; pfam05229 266835018356 Uncharacterized secreted protein [Function unknown]; Region: COG5430 266835018357 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 266835018358 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 266835018359 PapC C-terminal domain; Region: PapC_C; pfam13953 266835018360 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 266835018361 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 266835018362 Uncharacterized secreted protein [Function unknown]; Region: COG5430 266835018363 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 266835018364 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 266835018365 ATP-grasp domain; Region: ATP-grasp_4; cl17255 266835018366 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 266835018367 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 266835018368 carboxyltransferase (CT) interaction site; other site 266835018369 biotinylation site [posttranslational modification]; other site 266835018370 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 266835018371 putative ADP-ribose binding site [chemical binding]; other site 266835018372 putative active site [active] 266835018373 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 266835018374 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 266835018375 isovaleryl-CoA dehydrogenase; Region: PLN02519 266835018376 Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156 266835018377 substrate binding site [chemical binding]; other site 266835018378 FAD binding site [chemical binding]; other site 266835018379 catalytic base [active] 266835018380 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266835018381 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266835018382 Acylphosphatase; Region: Acylphosphatase; cl00551 266835018383 Transcriptional regulators [Transcription]; Region: MarR; COG1846 266835018384 MarR family; Region: MarR_2; cl17246 266835018385 histidinol-phosphate aminotransferase; Provisional; Region: PRK08153 266835018386 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 266835018387 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266835018388 homodimer interface [polypeptide binding]; other site 266835018389 catalytic residue [active] 266835018390 Porin subfamily; Region: Porin_2; pfam02530 266835018391 Porin subfamily; Region: Porin_2; pfam02530 266835018392 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 266835018393 Phage HP1 integrase, C-terminal catalytic domain. Bacteriophage HP1 and related integrases are found in eubacteria, plasmids and temperate bacteriophages of the P2 family. They belong to the DNA breaking-rejoining enzyme superfamily, which includes...; Region: HP1_INT_C; cd00797 266835018394 dimer interface [polypeptide binding]; other site 266835018395 active site 266835018396 catalytic residues [active] 266835018397 Int/Topo IB signature motif; other site 266835018398 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 266835018399 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 266835018400 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 266835018401 N-acetyl-D-glucosamine binding site [chemical binding]; other site 266835018402 catalytic residue [active] 266835018403 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 266835018404 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 266835018405 dimer interface [polypeptide binding]; other site 266835018406 active site 266835018407 catalytic residue [active] 266835018408 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 266835018409 SmpB-tmRNA interface; other site 266835018410 Uncharacterized bacterial muramidase containing a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis...; Region: GH25_muramidase_1; cd06413 266835018411 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 266835018412 active site 266835018413 Predicted transcriptional regulators [Transcription]; Region: COG1733 266835018414 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 266835018415 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 266835018416 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 266835018417 putative NAD(P) binding site [chemical binding]; other site 266835018418 dimer interface [polypeptide binding]; other site 266835018419 Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031 266835018420 Fe-S cluster binding site [ion binding]; other site 266835018421 DNA binding site [nucleotide binding] 266835018422 active site 266835018423 Uncharacterized conserved protein [Function unknown]; Region: COG1432 266835018424 LabA_like proteins; Region: LabA; cd10911 266835018425 putative metal binding site [ion binding]; other site 266835018426 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 266835018427 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 266835018428 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 266835018429 Zn2+ binding site [ion binding]; other site 266835018430 Mg2+ binding site [ion binding]; other site 266835018431 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 266835018432 synthetase active site [active] 266835018433 NTP binding site [chemical binding]; other site 266835018434 metal binding site [ion binding]; metal-binding site 266835018435 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 266835018436 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 266835018437 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 266835018438 active site 266835018439 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 266835018440 dimer interface [polypeptide binding]; other site 266835018441 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266835018442 metal binding site [ion binding]; metal-binding site 266835018443 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3216 266835018444 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 266835018445 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 266835018446 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 266835018447 Catalytic site [active] 266835018448 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 266835018449 ribonuclease III; Reviewed; Region: PRK12371 266835018450 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 266835018451 dimerization interface [polypeptide binding]; other site 266835018452 active site 266835018453 metal binding site [ion binding]; metal-binding site 266835018454 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 266835018455 dsRNA binding site [nucleotide binding]; other site 266835018456 GTPase Era; Reviewed; Region: era; PRK00089 266835018457 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 266835018458 G1 box; other site 266835018459 GTP/Mg2+ binding site [chemical binding]; other site 266835018460 Switch I region; other site 266835018461 G2 box; other site 266835018462 Switch II region; other site 266835018463 G3 box; other site 266835018464 G4 box; other site 266835018465 G5 box; other site 266835018466 KH domain; Region: KH_2; pfam07650 266835018467 Porin subfamily; Region: Porin_2; pfam02530 266835018468 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 266835018469 Recombination protein O N terminal; Region: RecO_N; pfam11967 266835018470 Recombination protein O C terminal; Region: RecO_C; pfam02565 266835018471 Predicted membrane protein [Function unknown]; Region: COG5373 266835018472 Predicted membrane protein [Function unknown]; Region: COG5373 266835018473 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 266835018474 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 266835018475 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 266835018476 DNA binding residues [nucleotide binding] 266835018477 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 266835018478 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 266835018479 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 266835018480 Coenzyme A binding pocket [chemical binding]; other site 266835018481 Peptidase_C39 like family; Region: DUF3335; pfam11814 266835018482 RimK-like ATPgrasp N-terminal domain; Region: RLAN; pfam14401 266835018483 Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) [Coenzyme metabolism / Translation, ribosomal structure and biogenesis]; Region: RimK; COG0189 266835018484 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 266835018485 Protein of unknown function (DUF3303); Region: DUF3303; pfam11746 266835018486 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266835018487 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 266835018488 dimerization interface [polypeptide binding]; other site 266835018489 substrate binding pocket [chemical binding]; other site 266835018490 This CD includes the putative hydrocarbon oxygenase, MocD, a bacterial rhizopine (3-O-methyl-scyllo-inosamine, 3-O-MSI) oxygenase, and other related proteins. It has been proposed that MocD, MocE (Rieske-like ferredoxin), and MocF (ferredoxin reductase)...; Region: Rhizopine-oxygenase-like; cd03511 266835018491 Fatty acid desaturase; Region: FA_desaturase; pfam00487 266835018492 putative di-iron ligands [ion binding]; other site 266835018493 similar to Predicted dehydrogenase 266835018494 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266835018495 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266835018496 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 266835018497 putative effector binding pocket; other site 266835018498 dimerization interface [polypeptide binding]; other site 266835018499 PAS fold; Region: PAS_7; pfam12860 266835018500 PAS fold; Region: PAS_7; pfam12860 266835018501 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 266835018502 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266835018503 metal binding site [ion binding]; metal-binding site 266835018504 active site 266835018505 I-site; other site 266835018506 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 266835018507 Predicted hydrolases of HD superfamily [General function prediction only]; Region: COG1896 266835018508 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 266835018509 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 266835018510 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 266835018511 dihydroorotase; Validated; Region: PRK09060 266835018512 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 266835018513 Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318 266835018514 active site 266835018515 Predicted secreted protein [Function unknown]; Region: COG5451 266835018516 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_15; cd04673 266835018517 nudix motif; other site 266835018518 Uncharacterized conserved protein [Function unknown]; Region: COG2135 266835018519 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 266835018520 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 266835018521 active site 266835018522 HIGH motif; other site 266835018523 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 266835018524 KMSKS motif; other site 266835018525 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 266835018526 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 266835018527 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266835018528 Uncharacterized conserved protein [Function unknown]; Region: COG3791 266835018529 Uncharacterized conserved protein [Function unknown]; Region: COG3791 266835018530 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 266835018531 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 266835018532 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 266835018533 active site 266835018534 catalytic residues [active] 266835018535 metal binding site [ion binding]; metal-binding site 266835018536 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 266835018537 rarD protein; Region: rarD; TIGR00688 266835018538 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 266835018539 Uncharacterized bacterial subgroup of the Salmonella typhimurium Zn2+ transporter ZntB-like subfamily; Region: ZntB_u1; cd12834 266835018540 Cl binding site [ion binding]; other site 266835018541 oligomer interface [polypeptide binding]; other site 266835018542 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 266835018543 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266835018544 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 266835018545 dimerization interface [polypeptide binding]; other site 266835018546 substrate binding pocket [chemical binding]; other site 266835018547 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 266835018548 Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652 266835018549 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 266835018550 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 266835018551 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 266835018552 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266835018553 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266835018554 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 266835018555 putative effector binding pocket; other site 266835018556 dimerization interface [polypeptide binding]; other site 266835018557 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266835018558 dimerization interface [polypeptide binding]; other site 266835018559 putative DNA binding site [nucleotide binding]; other site 266835018560 putative Zn2+ binding site [ion binding]; other site 266835018561 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 266835018562 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 266835018563 ATP-binding cassette domain of iron-sulfur clusters transporter, subfamily C; Region: ABCC_ATM1_transporter; cd03253 266835018564 Walker A/P-loop; other site 266835018565 ATP binding site [chemical binding]; other site 266835018566 Q-loop/lid; other site 266835018567 ABC transporter signature motif; other site 266835018568 Walker B; other site 266835018569 D-loop; other site 266835018570 H-loop/switch region; other site 266835018571 Benyvirus P25/P26 protein; Region: Benyvirus_P25; pfam05744 266835018572 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 266835018573 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 266835018574 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 266835018575 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 266835018576 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 266835018577 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 266835018578 putative acyl-acceptor binding pocket; other site 266835018579 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 266835018580 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 266835018581 acyl-activating enzyme (AAE) consensus motif; other site 266835018582 AMP binding site [chemical binding]; other site 266835018583 active site 266835018584 CoA binding site [chemical binding]; other site 266835018585 Uncharacterized protein, 4-oxalocrotonate tautomerase homolog [General function prediction only]; Region: COG1942 266835018586 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266835018587 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266835018588 dimerization interface [polypeptide binding]; other site 266835018589 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 266835018590 EamA-like transporter family; Region: EamA; pfam00892 266835018591 EamA-like transporter family; Region: EamA; pfam00892 266835018592 OsmC-like protein; Region: OsmC; pfam02566 266835018593 putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945 266835018594 classical (c) SDRs; Region: SDR_c; cd05233 266835018595 NAD(P) binding site [chemical binding]; other site 266835018596 active site 266835018597 amidophosphoribosyltransferase; Provisional; Region: PRK09123 266835018598 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 266835018599 active site 266835018600 tetramer interface [polypeptide binding]; other site 266835018601 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 266835018602 active site 266835018603 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 266835018604 Colicin V production protein; Region: Colicin_V; pfam02674 266835018605 DNA repair protein RadA; Provisional; Region: PRK11823 266835018606 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 266835018607 Walker A motif; other site 266835018608 ATP binding site [chemical binding]; other site 266835018609 Walker B motif; other site 266835018610 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 266835018611 replicative DNA helicase; Provisional; Region: PRK09165 266835018612 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 266835018613 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 266835018614 Walker A motif; other site 266835018615 ATP binding site [chemical binding]; other site 266835018616 Walker B motif; other site 266835018617 DNA binding loops [nucleotide binding] 266835018618 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 266835018619 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 266835018620 DNA binding residues [nucleotide binding] 266835018621 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 266835018622 Uncharacterized conserved protein [Function unknown]; Region: COG5507 266835018623 Protein of unknown function (DUF1428); Region: DUF1428; pfam07237 266835018624 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG5459 266835018625 Uncharacterized conserved protein [Function unknown]; Region: COG1742 266835018626 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 266835018627 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266835018628 S-adenosylmethionine binding site [chemical binding]; other site 266835018629 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 266835018630 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 266835018631 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 266835018632 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 266835018633 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 266835018634 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 266835018635 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 266835018636 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 266835018637 metal ion-dependent adhesion site (MIDAS); other site 266835018638 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 266835018639 Sulfatase; Region: Sulfatase; pfam00884 266835018640 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 266835018641 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 266835018642 3-ketoacyl-(acyl-carrier-protein) reductase NodG; Reviewed; Region: PRK12936 266835018643 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 266835018644 NAD(P) binding site [chemical binding]; other site 266835018645 homotetramer interface [polypeptide binding]; other site 266835018646 homodimer interface [polypeptide binding]; other site 266835018647 active site 266835018648 acyl carrier protein; Provisional; Region: acpP; PRK00982 266835018649 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 266835018650 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 266835018651 dimer interface [polypeptide binding]; other site 266835018652 active site 266835018653 Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559 266835018654 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 266835018655 dimerization interface [polypeptide binding]; other site 266835018656 Uncharacterized stress-induced protein [Function unknown]; Region: COG1561 266835018657 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 266835018658 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 266835018659 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 266835018660 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 266835018661 catalytic site [active] 266835018662 G-X2-G-X-G-K; other site 266835018663 Uncharacterized conserved protein [Function unknown]; Region: COG5470 266835018664 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 266835018665 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266835018666 S-adenosylmethionine binding site [chemical binding]; other site 266835018667 4-hydroxythreonine-4-phosphate dehydrogenase; Provisional; Region: pdxA; PRK05312 266835018668 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 266835018669 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 266835018670 SurA N-terminal domain; Region: SurA_N; pfam09312 266835018671 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 266835018672 OstA-like protein; Region: OstA; cl00844 266835018673 Organic solvent tolerance protein; Region: OstA_C; pfam04453 266835018674 Predicted permeases [General function prediction only]; Region: COG0795 266835018675 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 266835018676 Predicted permeases [General function prediction only]; Region: COG0795 266835018677 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 266835018678 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 266835018679 multifunctional aminopeptidase A; Provisional; Region: PRK00913 266835018680 interface (dimer of trimers) [polypeptide binding]; other site 266835018681 Substrate-binding/catalytic site; other site 266835018682 Zn-binding sites [ion binding]; other site 266835018683 DNA polymerase III subunit chi; Validated; Region: PRK05728 266835018684 Protein of unknown function (DUF995); Region: DUF995; pfam06191 266835018685 Beta-mannanase [Carbohydrate transport and metabolism]; Region: ManB; COG4124 266835018686 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 266835018687 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 266835018688 DXD motif; other site 266835018689 Protein of unknown function (DUF995); Region: DUF995; pfam06191 266835018690 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 266835018691 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 266835018692 NAD binding site [chemical binding]; other site 266835018693 homodimer interface [polypeptide binding]; other site 266835018694 active site 266835018695 substrate binding site [chemical binding]; other site 266835018696 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 266835018697 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 266835018698 NAD binding site [chemical binding]; other site 266835018699 putative substrate binding site 2 [chemical binding]; other site 266835018700 putative substrate binding site 1 [chemical binding]; other site 266835018701 active site 266835018702 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 266835018703 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266835018704 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266835018705 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 266835018706 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 266835018707 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 266835018708 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 266835018709 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266835018710 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_10; cd07251 266835018711 Bacteriophage capsid protein [General function prediction only]; Region: COG5511 266835018712 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266835018713 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266835018714 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 266835018715 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 266835018716 Transcriptional regulators [Transcription]; Region: MarR; COG1846 266835018717 Winged helix DNA-binding domain; Region: HTH_34; pfam13601 266835018718 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 266835018719 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 266835018720 putative C-terminal domain interface [polypeptide binding]; other site 266835018721 putative GSH binding site (G-site) [chemical binding]; other site 266835018722 putative dimer interface [polypeptide binding]; other site 266835018723 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 266835018724 dimer interface [polypeptide binding]; other site 266835018725 N-terminal domain interface [polypeptide binding]; other site 266835018726 putative substrate binding pocket (H-site) [chemical binding]; other site 266835018727 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 266835018728 short chain dehydrogenase; Provisional; Region: PRK09134 266835018729 pteridine reductase (PR), classical (c) SDRs; Region: PR_SDR_c; cd05357 266835018730 NADP binding site [chemical binding]; other site 266835018731 substrate binding pocket [chemical binding]; other site 266835018732 active site 266835018733 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 266835018734 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 266835018735 GIY-YIG motif/motif A; other site 266835018736 active site 266835018737 catalytic site [active] 266835018738 putative DNA binding site [nucleotide binding]; other site 266835018739 metal binding site [ion binding]; metal-binding site 266835018740 UvrB/uvrC motif; Region: UVR; pfam02151 266835018741 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 266835018742 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 266835018743 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 266835018744 MoaE interaction surface [polypeptide binding]; other site 266835018745 MoeB interaction surface [polypeptide binding]; other site 266835018746 thiocarboxylated glycine; other site 266835018747 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 266835018748 MoaE homodimer interface [polypeptide binding]; other site 266835018749 MoaD interaction [polypeptide binding]; other site 266835018750 active site residues [active] 266835018751 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3126 266835018752 Heat shock protein [Posttranslational modification, protein turnover, chaperones]; Region: HslJ; COG3187 266835018753 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 266835018754 active site 266835018755 multimer interface [polypeptide binding]; other site 266835018756 GST_N family, Beta etherase LigE subfamily; composed of proteins similar to Sphingomonas paucimobilis beta etherase, LigE, a GST-like protein that catalyzes the cleavage of the beta-aryl ether linkages present in low-moleculer weight lignins using GSH as...; Region: GST_N_etherase_LigE; cd03038 266835018757 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 266835018758 putative C-terminal domain interface [polypeptide binding]; other site 266835018759 putative GSH binding site (G-site) [chemical binding]; other site 266835018760 putative dimer interface [polypeptide binding]; other site 266835018761 C-terminal, alpha helical domain of Beta etherase LigE; Region: GST_C_etherase_LigE; cd03202 266835018762 putative N-terminal domain interface [polypeptide binding]; other site 266835018763 putative dimer interface [polypeptide binding]; other site 266835018764 putative substrate binding pocket (H-site) [chemical binding]; other site 266835018765 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DinB; COG2318 266835018766 DinB superfamily; Region: DinB_2; pfam12867 266835018767 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 266835018768 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266835018769 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 266835018770 dimerization interface [polypeptide binding]; other site 266835018771 substrate binding pocket [chemical binding]; other site 266835018772 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 266835018773 EamA-like transporter family; Region: EamA; pfam00892 266835018774 Predicted transcriptional regulator [Transcription]; Region: COG4957 266835018775 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 266835018776 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 266835018777 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 266835018778 ABC transporter; Region: ABC_tran_2; pfam12848 266835018779 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 266835018780 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 266835018781 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 266835018782 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 266835018783 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 266835018784 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 266835018785 molybdopterin cofactor binding site; other site 266835018786 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 266835018787 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 266835018788 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 266835018789 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266835018790 putative DNA binding site [nucleotide binding]; other site 266835018791 putative Zn2+ binding site [ion binding]; other site 266835018792 AsnC family; Region: AsnC_trans_reg; pfam01037 266835018793 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 266835018794 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cd00640 266835018795 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 266835018796 catalytic residue [active] 266835018797 allantoate amidohydrolase; Reviewed; Region: PRK12890 266835018798 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 266835018799 active site 266835018800 metal binding site [ion binding]; metal-binding site 266835018801 dimer interface [polypeptide binding]; other site 266835018802 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 266835018803 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 266835018804 metal binding site [ion binding]; metal-binding site 266835018805 putative dimer interface [polypeptide binding]; other site 266835018806 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 266835018807 Part of AAA domain; Region: AAA_19; pfam13245 266835018808 Family description; Region: UvrD_C_2; pfam13538 266835018809 dihydrodipicolinate reductase; Provisional; Region: PRK00048 266835018810 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 266835018811 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 266835018812 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 266835018813 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 266835018814 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 266835018815 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 266835018816 Walker A/P-loop; other site 266835018817 ATP binding site [chemical binding]; other site 266835018818 Q-loop/lid; other site 266835018819 ABC transporter signature motif; other site 266835018820 Walker B; other site 266835018821 D-loop; other site 266835018822 H-loop/switch region; other site 266835018823 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 266835018824 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835018825 dimer interface [polypeptide binding]; other site 266835018826 conserved gate region; other site 266835018827 putative PBP binding loops; other site 266835018828 ABC-ATPase subunit interface; other site 266835018829 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 266835018830 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 266835018831 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 266835018832 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266835018833 dimer interface [polypeptide binding]; other site 266835018834 phosphorylation site [posttranslational modification] 266835018835 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266835018836 ATP binding site [chemical binding]; other site 266835018837 Mg2+ binding site [ion binding]; other site 266835018838 G-X-G motif; other site 266835018839 transcriptional regulatory protein TctD; Provisional; Region: PRK15479 266835018840 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266835018841 active site 266835018842 phosphorylation site [posttranslational modification] 266835018843 intermolecular recognition site; other site 266835018844 dimerization interface [polypeptide binding]; other site 266835018845 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266835018846 DNA binding site [nucleotide binding] 266835018847 Protein of unknown function (DUF680); Region: DUF680; pfam05079 266835018848 Protein of unknown function (DUF680); Region: DUF680; pfam05079 266835018849 Protein of unknown function (DUF680); Region: DUF680; pfam05079 266835018850 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 266835018851 catalytic core [active] 266835018852 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 266835018853 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 266835018854 active site 266835018855 substrate binding site [chemical binding]; other site 266835018856 cosubstrate binding site; other site 266835018857 catalytic site [active] 266835018858 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 266835018859 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 266835018860 dimerization interface [polypeptide binding]; other site 266835018861 putative ATP binding site [chemical binding]; other site 266835018862 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 266835018863 Domain of unknown function DUF20; Region: UPF0118; pfam01594 266835018864 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 266835018865 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 266835018866 hypothetical protein; Validated; Region: PRK09087 266835018867 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266835018868 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266835018869 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 266835018870 putative effector binding pocket; other site 266835018871 dimerization interface [polypeptide binding]; other site 266835018872 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 266835018873 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835018874 NAD(P) binding site [chemical binding]; other site 266835018875 active site 266835018876 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 266835018877 active site 266835018878 catalytic residues [active] 266835018879 DNA binding site [nucleotide binding] 266835018880 Int/Topo IB signature motif; other site 266835018881 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 266835018882 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 266835018883 active site 266835018884 phage recombination protein Bet; Region: bet_lambda; TIGR01913 266835018885 Siphovirus Gp157; Region: Sipho_Gp157; pfam05565 266835018886 Bacteriophage protein gp37 [Function unknown]; Region: COG4422 266835018887 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266835018888 non-specific DNA binding site [nucleotide binding]; other site 266835018889 salt bridge; other site 266835018890 sequence-specific DNA binding site [nucleotide binding]; other site 266835018891 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3750 266835018892 GcrA cell cycle regulator; Region: GcrA; cl11564 266835018893 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 266835018894 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 266835018895 cofactor binding site; other site 266835018896 DNA binding site [nucleotide binding] 266835018897 substrate interaction site [chemical binding]; other site 266835018898 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3183 266835018899 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 266835018900 active site 266835018901 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3756 266835018902 N-Utilization Substance G (NusG) N-terminal (NGN) domain Superfamily; Region: NGN; cl02766 266835018903 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 266835018904 heterodimer interface [polypeptide binding]; other site 266835018905 Domain of unknown function (DUF4145); Region: DUF4145; pfam13643 266835018906 Uncharacterized conserved protein (DUF2280); Region: DUF2280; pfam10045 266835018907 Terminase-like family; Region: Terminase_6; pfam03237 266835018908 Phage-related terminase [General function prediction only]; Region: COG5362 266835018909 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3567 266835018910 phage-related protein, HI1409 family; Region: phge_rel_HI1409; TIGR01555 266835018911 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3566 266835018912 Uncharacterized protein conserved in bacteria (DUF2213); Region: DUF2213; pfam09979 266835018913 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4834 266835018914 Uncharacterized protein conserved in bacteria (DUF2184); Region: DUF2184; pfam09950 266835018915 Bacteriophage related domain of unknown function; Region: DUF4128; pfam13554 266835018916 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 266835018917 active site 266835018918 catalytic triad [active] 266835018919 oxyanion hole [active] 266835018920 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 266835018921 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 266835018922 Lysozyme family protein [General function prediction only]; Region: zliS; COG3926 266835018923 Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838 266835018924 Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374 266835018925 Protein of unknown function (DUF1515); Region: DUF1515; pfam07439 266835018926 Protein of unknown function (DUF3606); Region: DUF3606; pfam12244 266835018927 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 266835018928 DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779 266835018929 active site 266835018930 DNA binding site [nucleotide binding] 266835018931 O-methyltransferase; Region: Methyltransf_2; pfam00891 266835018932 aldehyde oxidoreductase 2Fe-2S subunit; Provisional; Region: PRK11433 266835018933 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 266835018934 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 266835018935 Predicted membrane protein [Function unknown]; Region: COG4331 266835018936 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 266835018937 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 266835018938 active site 266835018939 PRC-barrel domain; Region: PRC; pfam05239 266835018940 Uncharacterized conserved protein [Function unknown]; Region: COG2135 266835018941 ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224 266835018942 Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905 266835018943 active site 266835018944 DNA binding site [nucleotide binding] 266835018945 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970 266835018946 DNA binding site [nucleotide binding] 266835018947 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 266835018948 Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548 266835018949 PAS domain; Region: PAS_9; pfam13426 266835018950 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 266835018951 GAF domain; Region: GAF; pfam01590 266835018952 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 266835018953 GAF domain; Region: GAF; pfam01590 266835018954 PAS fold; Region: PAS_3; pfam08447 266835018955 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 266835018956 GAF domain; Region: GAF; pfam01590 266835018957 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266835018958 dimer interface [polypeptide binding]; other site 266835018959 phosphorylation site [posttranslational modification] 266835018960 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266835018961 ATP binding site [chemical binding]; other site 266835018962 Mg2+ binding site [ion binding]; other site 266835018963 G-X-G motif; other site 266835018964 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 266835018965 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266835018966 active site 266835018967 phosphorylation site [posttranslational modification] 266835018968 intermolecular recognition site; other site 266835018969 dimerization interface [polypeptide binding]; other site 266835018970 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 266835018971 Protein of unknown function (DUF1236); Region: DUF1236; pfam06823 266835018972 Predicted small integral membrane protein [Function unknown]; Region: COG5478 266835018973 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 266835018974 putative active site [active] 266835018975 catalytic site [active] 266835018976 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 266835018977 PLD-like domain; Region: PLDc_2; pfam13091 266835018978 putative active site [active] 266835018979 catalytic site [active] 266835018980 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 266835018981 Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400 266835018982 putative active site [active] 266835018983 putative metal binding site [ion binding]; other site 266835018984 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 266835018985 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 266835018986 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 266835018987 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 266835018988 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 266835018989 active site 266835018990 RecA-superfamily ATPases implicated in signal transduction [Signal transduction mechanisms]; Region: RAD55; COG0467 266835018991 KaiC is a circadian clock protein primarily found in cyanobacteria KaiC is a RecA-like ATPase, having both Walker A and Walker B motifs. A related protein is found in archaea; Region: KaiC; cd01124 266835018992 Walker A motif; other site 266835018993 ATP binding site [chemical binding]; other site 266835018994 Walker B motif; other site 266835018995 KaiC; Region: KaiC; pfam06745 266835018996 KaiC is a circadian clock protein primarily found in cyanobacteria KaiC is a RecA-like ATPase, having both Walker A and Walker B motifs. A related protein is found in archaea; Region: KaiC; cd01124 266835018997 Walker A motif; other site 266835018998 ATP binding site [chemical binding]; other site 266835018999 Walker B motif; other site 266835019000 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 266835019001 HWE histidine kinase; Region: HWE_HK; pfam07536 266835019002 PAS domain; Region: PAS_8; pfam13188 266835019003 PAS domain; Region: PAS_9; pfam13426 266835019004 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 266835019005 Histidine kinase; Region: HisKA_2; pfam07568 266835019006 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266835019007 ATP binding site [chemical binding]; other site 266835019008 Mg2+ binding site [ion binding]; other site 266835019009 G-X-G motif; other site 266835019010 Uncharacterized conserved protein [Function unknown]; Region: COG3496 266835019011 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 266835019012 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 266835019013 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 266835019014 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 266835019015 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 266835019016 DNA binding residues [nucleotide binding] 266835019017 anti-sigma factor, putative, ChrR family; Region: anti_sig_ChrR; TIGR02451 266835019018 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 266835019019 Steroid 5-alpha reductase family enzyme [General function prediction only]; Region: COG3752 266835019020 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 266835019021 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266835019022 S-adenosylmethionine binding site [chemical binding]; other site 266835019023 Predicted membrane protein [Function unknown]; Region: COG4852 266835019024 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 266835019025 DNA photolyase; Region: DNA_photolyase; pfam00875 266835019026 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4731 266835019027 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 266835019028 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 266835019029 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 266835019030 Protein of unknown function (DUF3102); Region: DUF3102; pfam11300 266835019031 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 266835019032 DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779 266835019033 active site 266835019034 DNA binding site [nucleotide binding] 266835019035 The Oligonucleotide/oligosaccharide binding (OB)-fold domain is a DNA-binding module that is part of the catalytic core unit of ATP dependent DNA ligases; Region: OBF_DNA_ligase_family; cl08424 266835019036 DNA binding site [nucleotide binding] 266835019037 Protein of unknown function (DUF768); Region: DUF768; pfam05589 266835019038 RepB plasmid partitioning protein; Region: RepB; pfam07506 266835019039 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 266835019040 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 266835019041 catalytic residues [active] 266835019042 catalytic nucleophile [active] 266835019043 Recombinase; Region: Recombinase; pfam07508 266835019044 Methyltransferase domain; Region: Methyltransf_23; pfam13489 266835019045 Methyltransferase domain; Region: Methyltransf_12; pfam08242 266835019046 Staphylococcal nuclease homologues; Region: SNc; smart00318 266835019047 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 266835019048 Catalytic site; other site 266835019049 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 266835019050 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266835019051 metal binding site [ion binding]; metal-binding site 266835019052 active site 266835019053 I-site; other site 266835019054 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 266835019055 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 266835019056 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 266835019057 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 266835019058 transmembrane helices; other site 266835019059 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 266835019060 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266835019061 binding surface 266835019062 TPR motif; other site 266835019063 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266835019064 TPR motif; other site 266835019065 binding surface 266835019066 TPR repeat; Region: TPR_11; pfam13414 266835019067 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266835019068 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266835019069 enoyl-CoA hydratase; Provisional; Region: PRK05980 266835019070 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266835019071 substrate binding site [chemical binding]; other site 266835019072 oxyanion hole (OAH) forming residues; other site 266835019073 trimer interface [polypeptide binding]; other site 266835019074 Plastocyanin [Energy production and conversion]; Region: PetE; COG3794 266835019075 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 266835019076 Predicted outer membrane protein [Function unknown]; Region: COG3652 266835019077 RNA polymerase sigma factor; Provisional; Region: PRK11922 266835019078 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 266835019079 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 266835019080 DNA binding residues [nucleotide binding] 266835019081 Choloylglycine hydrolase (CGH) is a bile salt-modifying enzyme that hydrolyzes non-peptide carbon-nitrogen bonds in choloylglycine and choloyltaurine, both of which are present in bile. CGH is present in a number of probiotic microbial organisms that...; Region: Ntn_CGH; cd01902 266835019082 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 266835019083 CBS-domain-containing membrane protein [Signal transduction mechanisms]; Region: COG3448 266835019084 HPP family; Region: HPP; pfam04982 266835019085 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 266835019086 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the HPP motif domain. These proteins are integral membrane proteins with four transmembrane spanning helices. The function of these proteins is...; Region: CBS_pair_HPP_assoc; cd04600 266835019087 cystathionine beta-lyase; Provisional; Region: PRK05967 266835019088 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 266835019089 homodimer interface [polypeptide binding]; other site 266835019090 substrate-cofactor binding pocket; other site 266835019091 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266835019092 catalytic residue [active] 266835019093 Uncharacterized conserved protein [Function unknown]; Region: COG5588 266835019094 Predicted metal-binding integral membrane protein [Function unknown]; Region: COG5486 266835019095 Predicted metal-binding integral membrane protein (DUF2182); Region: DUF2182; pfam09948 266835019096 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 266835019097 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 266835019098 substrate binding pocket [chemical binding]; other site 266835019099 membrane-bound complex binding site; other site 266835019100 hinge residues; other site 266835019101 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597 266835019102 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 266835019103 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835019104 dimer interface [polypeptide binding]; other site 266835019105 conserved gate region; other site 266835019106 putative PBP binding loops; other site 266835019107 ABC-ATPase subunit interface; other site 266835019108 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835019109 dimer interface [polypeptide binding]; other site 266835019110 conserved gate region; other site 266835019111 putative PBP binding loops; other site 266835019112 ABC-ATPase subunit interface; other site 266835019113 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 266835019114 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 266835019115 Walker A/P-loop; other site 266835019116 ATP binding site [chemical binding]; other site 266835019117 Q-loop/lid; other site 266835019118 ABC transporter signature motif; other site 266835019119 Walker B; other site 266835019120 D-loop; other site 266835019121 H-loop/switch region; other site 266835019122 Protein of unknown function (DUF2459); Region: DUF2459; pfam09601 266835019123 salicylate hydroxylase; Provisional; Region: PRK08163 266835019124 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 266835019125 polyphosphate kinase; Provisional; Region: PRK05443 266835019126 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 266835019127 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 266835019128 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 266835019129 putative domain interface [polypeptide binding]; other site 266835019130 putative active site [active] 266835019131 catalytic site [active] 266835019132 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 266835019133 putative domain interface [polypeptide binding]; other site 266835019134 putative active site [active] 266835019135 catalytic site [active] 266835019136 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 266835019137 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 266835019138 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 266835019139 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266835019140 Walker A/P-loop; other site 266835019141 ATP binding site [chemical binding]; other site 266835019142 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 266835019143 putative active site [active] 266835019144 putative metal-binding site [ion binding]; other site 266835019145 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 266835019146 Part of AAA domain; Region: AAA_19; pfam13245 266835019147 Family description; Region: UvrD_C_2; pfam13538 266835019148 Predicted membrane protein [Function unknown]; Region: COG2259 266835019149 Predicted membrane protein [Function unknown]; Region: COG2259 266835019150 fumarate hydratase; Reviewed; Region: fumC; PRK00485 266835019151 Class II fumarases; Region: Fumarase_classII; cd01362 266835019152 active site 266835019153 tetramer interface [polypeptide binding]; other site 266835019154 short chain dehydrogenase; Provisional; Region: PRK06500 266835019155 classical (c) SDRs; Region: SDR_c; cd05233 266835019156 NAD(P) binding site [chemical binding]; other site 266835019157 active site 266835019158 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 266835019159 NIPSNAP; Region: NIPSNAP; pfam07978 266835019160 NIPSNAP; Region: NIPSNAP; pfam07978 266835019161 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266835019162 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266835019163 Cytolysin, a secreted calcineurin-like phosphatase [Cell motility and secretion]; Region: COG5555 266835019164 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 266835019165 CsbD-like; Region: CsbD; pfam05532 266835019166 GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043 266835019167 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 266835019168 putative C-terminal domain interface [polypeptide binding]; other site 266835019169 putative GSH binding site (G-site) [chemical binding]; other site 266835019170 putative dimer interface [polypeptide binding]; other site 266835019171 C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194 266835019172 putative substrate binding pocket (H-site) [chemical binding]; other site 266835019173 putative N-terminal domain interface [polypeptide binding]; other site 266835019174 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266835019175 dimerization interface [polypeptide binding]; other site 266835019176 putative DNA binding site [nucleotide binding]; other site 266835019177 putative Zn2+ binding site [ion binding]; other site 266835019178 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 266835019179 putative hydrophobic ligand binding site [chemical binding]; other site 266835019180 YCII-related domain; Region: YCII; pfam03795 266835019181 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 266835019182 DNA-binding site [nucleotide binding]; DNA binding site 266835019183 RNA-binding motif; other site 266835019184 Flagellin N-methylase; Region: FliB; cl00497 266835019185 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 266835019186 SnoaL-like domain; Region: SnoaL_2; pfam12680 266835019187 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 266835019188 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276 266835019189 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 266835019190 putative NAD(P) binding site [chemical binding]; other site 266835019191 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266835019192 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266835019193 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 266835019194 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 266835019195 ring oligomerisation interface [polypeptide binding]; other site 266835019196 ATP/Mg binding site [chemical binding]; other site 266835019197 stacking interactions; other site 266835019198 hinge regions; other site 266835019199 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 266835019200 oligomerisation interface [polypeptide binding]; other site 266835019201 mobile loop; other site 266835019202 roof hairpin; other site 266835019203 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266835019204 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266835019205 Major Facilitator Superfamily; Region: MFS_1; pfam07690 266835019206 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 266835019207 FAD binding domain; Region: FAD_binding_4; pfam01565 266835019208 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 266835019209 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 266835019210 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 3; Region: PLPDE_III_DSD_D-TA_like_3; cd06814 266835019211 dimer interface [polypeptide binding]; other site 266835019212 active site 266835019213 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 266835019214 substrate binding site [chemical binding]; other site 266835019215 catalytic residue [active] 266835019216 Transcriptional regulators [Transcription]; Region: MarR; COG1846 266835019217 MarR family; Region: MarR_2; pfam12802 266835019218 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 266835019219 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 266835019220 Coenzyme A binding pocket [chemical binding]; other site 266835019221 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 266835019222 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 266835019223 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 266835019224 Transcriptional regulators [Transcription]; Region: PurR; COG1609 266835019225 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 266835019226 DNA binding site [nucleotide binding] 266835019227 domain linker motif; other site 266835019228 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 266835019229 ligand binding site [chemical binding]; other site 266835019230 dimerization interface [polypeptide binding]; other site 266835019231 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 266835019232 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 266835019233 Walker A/P-loop; other site 266835019234 ATP binding site [chemical binding]; other site 266835019235 Q-loop/lid; other site 266835019236 ABC transporter signature motif; other site 266835019237 Walker B; other site 266835019238 D-loop; other site 266835019239 H-loop/switch region; other site 266835019240 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 266835019241 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 266835019242 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 266835019243 TM-ABC transporter signature motif; other site 266835019244 Periplasmic binding domain of two-component sensor kinase signaling systems; Region: PBP1_sensor_kinase_like; cd06308 266835019245 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 266835019246 putative ligand binding site [chemical binding]; other site 266835019247 EamA-like transporter family; Region: EamA; pfam00892 266835019248 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 266835019249 EamA-like transporter family; Region: EamA; pfam00892 266835019250 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 266835019251 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 266835019252 Subfamily of PAN/APPLE-like domains; present in plasma prekallikrein/coagulation factor XI, microneme antigen proteins, and a few prokaryotic proteins. PAN/APPLE domains fulfill diverse biological functions by mediating protein-protein or...; Region: APPLE_Factor_XI_like; cd01100 266835019253 putative binding site; other site 266835019254 PAN/APPLE-like domain; present in N-terminal (N) domains of plasminogen/ hepatocyte growth factor proteins, plasma prekallikrein/coagulation factor XI and microneme antigen proteins, plant receptor-like protein kinases, and various nematode and leech...; Region: PAN_APPLE; cl00112 266835019255 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 266835019256 Predicted metal-binding protein [Function unknown]; Region: COG5469 266835019257 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 266835019258 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 266835019259 Walker A/P-loop; other site 266835019260 ATP binding site [chemical binding]; other site 266835019261 Q-loop/lid; other site 266835019262 ABC transporter signature motif; other site 266835019263 Walker B; other site 266835019264 D-loop; other site 266835019265 H-loop/switch region; other site 266835019266 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 266835019267 Metal binding protein TroA_a. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148 266835019268 putative ligand binding residues [chemical binding]; other site 266835019269 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 266835019270 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 266835019271 ABC-ATPase subunit interface; other site 266835019272 dimer interface [polypeptide binding]; other site 266835019273 putative PBP binding regions; other site 266835019274 Transcriptional regulators [Transcription]; Region: MarR; COG1846 266835019275 MarR family; Region: MarR_2; pfam12802 266835019276 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 266835019277 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 266835019278 HlyD family secretion protein; Region: HlyD_3; pfam13437 266835019279 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 266835019280 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266835019281 putative substrate translocation pore; other site 266835019282 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 266835019283 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 266835019284 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 266835019285 Predicted integral membrane protein [Function unknown]; Region: COG5473 266835019286 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 266835019287 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 266835019288 Putative Flp pilus-assembly TadE/G-like; Region: Tad; pfam13400 266835019289 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 266835019290 metal ion-dependent adhesion site (MIDAS); other site 266835019291 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 266835019292 Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344 266835019293 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 266835019294 motif I; other site 266835019295 active site 266835019296 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 266835019297 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 266835019298 active site 266835019299 Riboflavin kinase; Region: Flavokinase; smart00904 266835019300 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 266835019301 Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511 266835019302 acid phosphatase, Burkholderia-type; Region: acid_phos_Burk; TIGR03397 266835019303 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 266835019304 isoleucyl-tRNA synthetase; Provisional; Region: ileS; PRK13804 266835019305 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 266835019306 active site 266835019307 HIGH motif; other site 266835019308 nucleotide binding site [chemical binding]; other site 266835019309 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 266835019310 active site 266835019311 KMSKS motif; other site 266835019312 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 266835019313 tRNA binding surface [nucleotide binding]; other site 266835019314 anticodon binding site; other site 266835019315 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 266835019316 nucleoside/Zn binding site; other site 266835019317 dimer interface [polypeptide binding]; other site 266835019318 catalytic motif [active] 266835019319 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 266835019320 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 266835019321 RNA binding surface [nucleotide binding]; other site 266835019322 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 266835019323 active site 266835019324 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 266835019325 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266835019326 S-adenosylmethionine binding site [chemical binding]; other site 266835019327 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 266835019328 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 266835019329 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 266835019330 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 266835019331 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 266835019332 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 266835019333 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 266835019334 nucleophile elbow; other site 266835019335 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 266835019336 RibD C-terminal domain; Region: RibD_C; pfam01872 266835019337 elongation factor P; Validated; Region: PRK00529 266835019338 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 266835019339 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 266835019340 RNA binding site [nucleotide binding]; other site 266835019341 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 266835019342 RNA binding site [nucleotide binding]; other site 266835019343 Truncated, possibly inactive, lysyl-tRNA synthetase (class II) [Translation, ribosomal structure and biogenesis]; Region: COG2269 266835019344 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 266835019345 motif 1; other site 266835019346 dimer interface [polypeptide binding]; other site 266835019347 active site 266835019348 motif 2; other site 266835019349 motif 3; other site 266835019350 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_18; cd08357 266835019351 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266835019352 putative metal binding site [ion binding]; other site 266835019353 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 266835019354 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 266835019355 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 266835019356 active site 266835019357 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: DUF374; Region: LPLAT_DUF374-like; cd07983 266835019358 putative acyl-acceptor binding pocket; other site 266835019359 3-deoxy-D-manno-octulosonic-acid transferase [Cell envelope biogenesis, outer membrane]; Region: KdtA; COG1519 266835019360 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 266835019361 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 266835019362 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 266835019363 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3908 266835019364 putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418 266835019365 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266835019366 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 266835019367 dimerization interface [polypeptide binding]; other site 266835019368 substrate binding pocket [chemical binding]; other site 266835019369 EamA-like transporter family; Region: EamA; pfam00892 266835019370 EamA-like transporter family; Region: EamA; pfam00892 266835019371 Domain of unknown function (DUF1905); Region: DUF1905; pfam08922 266835019372 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 266835019373 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266835019374 ATP binding site [chemical binding]; other site 266835019375 Mg2+ binding site [ion binding]; other site 266835019376 G-X-G motif; other site 266835019377 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 266835019378 ATP binding site [chemical binding]; other site 266835019379 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 266835019380 putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418 266835019381 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266835019382 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 266835019383 dimerization interface [polypeptide binding]; other site 266835019384 substrate binding pocket [chemical binding]; other site 266835019385 Trimethylamine methyltransferase (MTTB); Region: MTTB; pfam06253 266835019386 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 266835019387 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 266835019388 Protein of unknown function (DUF3828); Region: DUF3828; pfam12883 266835019389 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 266835019390 active site 266835019391 Protein of unknown function (DUF3828); Region: DUF3828; pfam12883 266835019392 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 266835019393 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 266835019394 Old yellow enzyme (OYE)-related FMN binding domain, group 3. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_3_FMN; cd04734 266835019395 putative active site [active] 266835019396 putative FMN binding site [chemical binding]; other site 266835019397 putative substrate binding site [chemical binding]; other site 266835019398 putative catalytic residue [active] 266835019399 Transcriptional regulators [Transcription]; Region: MarR; COG1846 266835019400 MarR family; Region: MarR; pfam01047 266835019401 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 266835019402 Putative catalytic NodB homology domain of uncharacterized Mll8295 protein encoded from Rhizobium loti and its bacterial homologs; Region: CE4_Mll8295_like; cd10946 266835019403 NodB motif; other site 266835019404 putative active site [active] 266835019405 putative catalytic site [active] 266835019406 putative Zn binding site [ion binding]; other site 266835019407 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266835019408 metal binding site [ion binding]; metal-binding site 266835019409 active site 266835019410 I-site; other site 266835019411 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 266835019412 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 266835019413 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 266835019414 substrate-cofactor binding pocket; other site 266835019415 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266835019416 catalytic residue [active] 266835019417 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 266835019418 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 266835019419 NAD(P) binding site [chemical binding]; other site 266835019420 Domain of unknown function (DUF4304); Region: DUF4304; pfam14137 266835019421 MarR family; Region: MarR_2; cl17246 266835019422 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 266835019423 homogentisate 1,2-dioxygenase; Provisional; Region: PRK05341 266835019424 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 266835019425 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 266835019426 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 266835019427 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DinB; COG2318 266835019428 DinB superfamily; Region: DinB_2; pfam12867 266835019429 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185 266835019430 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 266835019431 dimer interface [polypeptide binding]; other site 266835019432 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 266835019433 active site 266835019434 Fe binding site [ion binding]; other site 266835019435 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 266835019436 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266835019437 putative DNA binding site [nucleotide binding]; other site 266835019438 putative Zn2+ binding site [ion binding]; other site 266835019439 AsnC family; Region: AsnC_trans_reg; pfam01037 266835019440 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3453 266835019441 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 266835019442 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 266835019443 metal binding site [ion binding]; metal-binding site 266835019444 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 266835019445 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 266835019446 ABC-ATPase subunit interface; other site 266835019447 dimer interface [polypeptide binding]; other site 266835019448 putative PBP binding regions; other site 266835019449 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 266835019450 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 266835019451 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 266835019452 homotrimer interaction site [polypeptide binding]; other site 266835019453 putative active site [active] 266835019454 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 266835019455 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266835019456 DNA-binding site [nucleotide binding]; DNA binding site 266835019457 UTRA domain; Region: UTRA; pfam07702 266835019458 N-formimino-L-glutamate deiminase; Validated; Region: PRK09229 266835019459 Metallo-dependent hydrolases, subgroup D is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_E; cd01313 266835019460 active site 266835019461 imidazolonepropionase; Validated; Region: PRK09356 266835019462 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 266835019463 active site 266835019464 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 266835019465 active sites [active] 266835019466 tetramer interface [polypeptide binding]; other site 266835019467 N-formylglutamate amidohydrolase; Region: hutG_amidohyd; TIGR02017 266835019468 urocanate hydratase; Provisional; Region: PRK05414 266835019469 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3758 266835019470 Protein of unknown function (DUF3131); Region: DUF3131; pfam11329 266835019471 Putative glucoamylase; Region: Glycoamylase; pfam10091 266835019472 Second GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_2_like; cd11753 266835019473 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 266835019474 First GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_1_like; cd11756 266835019475 cyclic beta-1,2-glucan ABC transporter; Provisional; Region: PRK13657 266835019476 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 266835019477 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 266835019478 Walker A/P-loop; other site 266835019479 ATP binding site [chemical binding]; other site 266835019480 Q-loop/lid; other site 266835019481 ABC transporter signature motif; other site 266835019482 Walker B; other site 266835019483 D-loop; other site 266835019484 H-loop/switch region; other site 266835019485 heme exporter protein CcmC; Region: ccmC; TIGR01191 266835019486 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 266835019487 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Low Specificity D-Threonine Aldolase-like; Region: PLPDE_III_LS_D-TA_like; cd06820 266835019488 dimer interface [polypeptide binding]; other site 266835019489 active site 266835019490 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 266835019491 substrate binding site [chemical binding]; other site 266835019492 catalytic residue [active] 266835019493 Protein of unknown function (DUF1498); Region: DUF1498; pfam07385 266835019494 Predicted membrane protein/domain [Function unknown]; Region: COG1714 266835019495 Uncharacterized membrane protein [Function unknown]; Region: SpoIIM; COG1300 266835019496 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 266835019497 Protein of unknown function DUF58; Region: DUF58; pfam01882 266835019498 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 266835019499 metal ion-dependent adhesion site (MIDAS); other site 266835019500 MoxR-like ATPases [General function prediction only]; Region: COG0714 266835019501 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266835019502 Walker A motif; other site 266835019503 ATP binding site [chemical binding]; other site 266835019504 Walker B motif; other site 266835019505 arginine finger; other site 266835019506 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 266835019507 Protein of unknown function (DUF975); Region: DUF975; cl10504 266835019508 Cupin domain; Region: Cupin_2; cl17218 266835019509 Predicted integral membrane protein [Function unknown]; Region: COG0392 266835019510 exopolyphosphatase; Region: exo_poly_only; TIGR03706 266835019511 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 266835019512 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 266835019513 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266835019514 S-adenosylmethionine binding site [chemical binding]; other site 266835019515 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266835019516 Major Facilitator Superfamily; Region: MFS_1; pfam07690 266835019517 putative substrate translocation pore; other site 266835019518 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266835019519 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 266835019520 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 266835019521 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 266835019522 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 266835019523 active site 266835019524 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5331 266835019525 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 266835019526 Protein of unknown function (DUF1624); Region: DUF1624; cl01394 266835019527 ribonuclease D; Region: rnd; TIGR01388 266835019528 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 266835019529 catalytic site [active] 266835019530 putative active site [active] 266835019531 putative substrate binding site [chemical binding]; other site 266835019532 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266835019533 putative substrate translocation pore; other site 266835019534 Major Facilitator Superfamily; Region: MFS_1; pfam07690 266835019535 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 266835019536 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 266835019537 dimer interface [polypeptide binding]; other site 266835019538 anticodon binding site; other site 266835019539 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 266835019540 homodimer interface [polypeptide binding]; other site 266835019541 motif 1; other site 266835019542 active site 266835019543 motif 2; other site 266835019544 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 266835019545 active site 266835019546 motif 3; other site 266835019547 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 266835019548 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 266835019549 CAP-like domain; other site 266835019550 active site 266835019551 primary dimer interface [polypeptide binding]; other site 266835019552 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 266835019553 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 266835019554 Domain of unknown function DUF20; Region: UPF0118; pfam01594 266835019555 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 266835019556 EamA-like transporter family; Region: EamA; cl17759 266835019557 Putative arginyl-tRNA:protein arginylyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG2935 266835019558 Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376 266835019559 Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377 266835019560 Predicted membrane protein/domain [Function unknown]; Region: COG1714 266835019561 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 266835019562 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 266835019563 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 266835019564 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 266835019565 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 266835019566 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 266835019567 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 266835019568 Predicted esterase [General function prediction only]; Region: COG0400 266835019569 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4645 266835019570 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 266835019571 Transcriptional regulators [Transcription]; Region: PurR; COG1609 266835019572 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 266835019573 DNA binding site [nucleotide binding] 266835019574 domain linker motif; other site 266835019575 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_3; cd06279 266835019576 putative dimerization interface [polypeptide binding]; other site 266835019577 putative ligand binding site [chemical binding]; other site 266835019578 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 266835019579 drug efflux system protein MdtG; Provisional; Region: PRK09874 266835019580 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266835019581 putative substrate translocation pore; other site 266835019582 Transcriptional regulators [Transcription]; Region: GntR; COG1802 266835019583 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266835019584 DNA-binding site [nucleotide binding]; DNA binding site 266835019585 FCD domain; Region: FCD; pfam07729 266835019586 Protein of unknown function (DUF982); Region: DUF982; pfam06169 266835019587 Putative lipopolysaccharide-modifying enzyme; Region: CAP10; smart00672 266835019588 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 266835019589 active site 266835019590 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 266835019591 catalytic tetrad [active] 266835019592 Uncharacterized conserved protein [Function unknown]; Region: COG2326 266835019593 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 266835019594 RibD C-terminal domain; Region: RibD_C; cl17279 266835019595 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 266835019596 dimer interface [polypeptide binding]; other site 266835019597 allosteric magnesium binding site [ion binding]; other site 266835019598 active site 266835019599 aspartate-rich active site metal binding site; other site 266835019600 Schiff base residues; other site 266835019601 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3249 266835019602 Uncharacterized protein conserved in bacteria (DUF2066); Region: DUF2066; pfam09839 266835019603 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 266835019604 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266835019605 substrate binding site [chemical binding]; other site 266835019606 oxyanion hole (OAH) forming residues; other site 266835019607 trimer interface [polypeptide binding]; other site 266835019608 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 266835019609 Transcriptional regulators [Transcription]; Region: MarR; COG1846 266835019610 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 266835019611 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989 266835019612 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 266835019613 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 266835019614 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 266835019615 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 266835019616 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 266835019617 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 266835019618 dimer interface [polypeptide binding]; other site 266835019619 active site 266835019620 glycine-pyridoxal phosphate binding site [chemical binding]; other site 266835019621 folate binding site [chemical binding]; other site 266835019622 Uncharacterized membrane protein required for alginate biosynthesis [General function prediction only]; Region: GlpM; COG3136 266835019623 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 266835019624 ATP cone domain; Region: ATP-cone; pfam03477 266835019625 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 266835019626 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 266835019627 catalytic motif [active] 266835019628 Zn binding site [ion binding]; other site 266835019629 RibD C-terminal domain; Region: RibD_C; cl17279 266835019630 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 266835019631 Lumazine binding domain; Region: Lum_binding; pfam00677 266835019632 Lumazine binding domain; Region: Lum_binding; pfam00677 266835019633 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 266835019634 homopentamer interface [polypeptide binding]; other site 266835019635 active site 266835019636 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 266835019637 putative RNA binding site [nucleotide binding]; other site 266835019638 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266835019639 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 266835019640 putative substrate translocation pore; other site 266835019641 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 266835019642 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835019643 dimer interface [polypeptide binding]; other site 266835019644 conserved gate region; other site 266835019645 ABC-ATPase subunit interface; other site 266835019646 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 266835019647 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 266835019648 Walker A/P-loop; other site 266835019649 ATP binding site [chemical binding]; other site 266835019650 Q-loop/lid; other site 266835019651 ABC transporter signature motif; other site 266835019652 Walker B; other site 266835019653 D-loop; other site 266835019654 H-loop/switch region; other site 266835019655 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835019656 putative PBP binding loops; other site 266835019657 dimer interface [polypeptide binding]; other site 266835019658 ABC-ATPase subunit interface; other site 266835019659 Inorganic pyrophosphatase [Energy production and conversion]; Region: OVP1; COG3808 266835019660 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 266835019661 Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913 266835019662 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 266835019663 Uncharacterized conserved protein [Function unknown]; Region: COG5452 266835019664 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 266835019665 putative phosphate acyltransferase; Provisional; Region: PRK05331 266835019666 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 266835019667 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 266835019668 dimer interface [polypeptide binding]; other site 266835019669 active site 266835019670 CoA binding pocket [chemical binding]; other site 266835019671 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 266835019672 IHF dimer interface [polypeptide binding]; other site 266835019673 IHF - DNA interface [nucleotide binding]; other site 266835019674 Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765 266835019675 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 266835019676 DNA binding residues [nucleotide binding] 266835019677 Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888 266835019678 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 266835019679 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266835019680 non-specific DNA binding site [nucleotide binding]; other site 266835019681 salt bridge; other site 266835019682 sequence-specific DNA binding site [nucleotide binding]; other site 266835019683 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 266835019684 putative deacylase active site [active] 266835019685 O-Antigen ligase; Region: Wzy_C; pfam04932 266835019686 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 266835019687 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 266835019688 NAD binding site [chemical binding]; other site 266835019689 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 266835019690 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 266835019691 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 266835019692 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 266835019693 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 266835019694 SLBB domain; Region: SLBB; pfam10531 266835019695 exopolysaccharide transport protein family; Region: eps_transp_fam; TIGR01005 266835019696 Chain length determinant protein; Region: Wzz; pfam02706 266835019697 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 266835019698 Hydantoin racemase [Amino acid transport and metabolism]; Region: COG4126 266835019699 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 266835019700 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835019701 dimer interface [polypeptide binding]; other site 266835019702 conserved gate region; other site 266835019703 putative PBP binding loops; other site 266835019704 ABC-ATPase subunit interface; other site 266835019705 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835019706 dimer interface [polypeptide binding]; other site 266835019707 conserved gate region; other site 266835019708 putative PBP binding loops; other site 266835019709 ABC-ATPase subunit interface; other site 266835019710 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 266835019711 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 266835019712 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 266835019713 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266835019714 Walker A/P-loop; other site 266835019715 ATP binding site [chemical binding]; other site 266835019716 Q-loop/lid; other site 266835019717 ABC transporter signature motif; other site 266835019718 Walker B; other site 266835019719 D-loop; other site 266835019720 H-loop/switch region; other site 266835019721 TOBE domain; Region: TOBE_2; pfam08402 266835019722 Transcriptional regulators [Transcription]; Region: GntR; COG1802 266835019723 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266835019724 DNA-binding site [nucleotide binding]; DNA binding site 266835019725 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 266835019726 Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653 266835019727 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 266835019728 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 266835019729 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 266835019730 Putative catalytic NodB homology domain of Mesorhizobium loti Mlr8448 protein and its bacterial homologs; Region: CE4_Mlr8448_like_5s; cd10968 266835019731 putative active site [active] 266835019732 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 266835019733 Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852 266835019734 Streptomycin 6-kinase [Defense mechanisms]; Region: StrB; COG3570 266835019735 Phosphotransferase enzyme family; Region: APH; pfam01636 266835019736 N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863 266835019737 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 266835019738 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 266835019739 agmatinase; Region: agmatinase; TIGR01230 266835019740 oligomer interface [polypeptide binding]; other site 266835019741 putative active site [active] 266835019742 Mn binding site [ion binding]; other site 266835019743 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 266835019744 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 266835019745 Glycerophosphodiester phosphodiesterase domain of Agrobacterium tumefaciens and similar proteins; Region: GDPD_AtGDE_like; cd08566 266835019746 putative active site [active] 266835019747 catalytic site [active] 266835019748 putative metal binding site [ion binding]; other site 266835019749 oligomer interface [polypeptide binding]; other site 266835019750 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 266835019751 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 266835019752 23S rRNA interface [nucleotide binding]; other site 266835019753 L3 interface [polypeptide binding]; other site 266835019754 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 266835019755 CoenzymeA binding site [chemical binding]; other site 266835019756 subunit interaction site [polypeptide binding]; other site 266835019757 PHB binding site; other site 266835019758 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 266835019759 enoyl-CoA hydratase; Validated; Region: PRK08139 266835019760 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266835019761 substrate binding site [chemical binding]; other site 266835019762 oxyanion hole (OAH) forming residues; other site 266835019763 trimer interface [polypeptide binding]; other site 266835019764 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266835019765 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_10; cd07251 266835019766 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266835019767 Predicted ATPase [General function prediction only]; Region: COG3910 266835019768 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266835019769 Walker A/P-loop; other site 266835019770 Walker A/P-loop; other site 266835019771 ATP binding site [chemical binding]; other site 266835019772 ATP binding site [chemical binding]; other site 266835019773 Q-loop/lid; other site 266835019774 ABC transporter signature motif; other site 266835019775 Walker B; other site 266835019776 D-loop; other site 266835019777 H-loop/switch region; other site 266835019778 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 266835019779 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK05994 266835019780 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 266835019781 homodimer interface [polypeptide binding]; other site 266835019782 substrate-cofactor binding pocket; other site 266835019783 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266835019784 catalytic residue [active] 266835019785 Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450 266835019786 Glycine/sarcosine/betaine reductase component B subunits; Region: Gly_reductase; pfam09338 266835019787 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 266835019788 Cytochrome P450; Region: p450; cl12078 266835019789 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 266835019790 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 266835019791 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 266835019792 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 266835019793 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 266835019794 oligomer interface [polypeptide binding]; other site 266835019795 active site residues [active] 266835019796 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 266835019797 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 266835019798 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 266835019799 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266835019800 Walker A motif; other site 266835019801 ATP binding site [chemical binding]; other site 266835019802 Walker B motif; other site 266835019803 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 266835019804 Found in ATP-dependent protease La (LON); Region: LON; smart00464 266835019805 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 266835019806 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266835019807 Walker A motif; other site 266835019808 ATP binding site [chemical binding]; other site 266835019809 Walker B motif; other site 266835019810 arginine finger; other site 266835019811 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 266835019812 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 266835019813 IHF dimer interface [polypeptide binding]; other site 266835019814 IHF - DNA interface [nucleotide binding]; other site 266835019815 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 266835019816 active site 266835019817 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 266835019818 catalytic tetrad [active] 266835019819 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 266835019820 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 266835019821 tetramer interface [polypeptide binding]; other site 266835019822 active site 266835019823 Uncharacterized protein, putative amidase [General function prediction only]; Region: COG1402 266835019824 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 266835019825 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835019826 dimer interface [polypeptide binding]; other site 266835019827 conserved gate region; other site 266835019828 putative PBP binding loops; other site 266835019829 ABC-ATPase subunit interface; other site 266835019830 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 266835019831 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835019832 putative PBP binding loops; other site 266835019833 dimer interface [polypeptide binding]; other site 266835019834 ABC-ATPase subunit interface; other site 266835019835 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 266835019836 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 266835019837 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 266835019838 Walker A/P-loop; other site 266835019839 ATP binding site [chemical binding]; other site 266835019840 Q-loop/lid; other site 266835019841 ABC transporter signature motif; other site 266835019842 Walker B; other site 266835019843 D-loop; other site 266835019844 H-loop/switch region; other site 266835019845 TOBE domain; Region: TOBE_2; pfam08402 266835019846 Fucose dissimilation pathway protein FucU [Carbohydrate transport and metabolism]; Region: FucU; COG4154 266835019847 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 266835019848 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 266835019849 substrate binding site [chemical binding]; other site 266835019850 dimer interface [polypeptide binding]; other site 266835019851 ATP binding site [chemical binding]; other site 266835019852 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 266835019853 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 266835019854 active site 266835019855 catalytic residues [active] 266835019856 DNA binding site [nucleotide binding] 266835019857 Int/Topo IB signature motif; other site 266835019858 Predicted transcriptional regulator [Transcription]; Region: COG2932 266835019859 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 266835019860 Catalytic site [active] 266835019861 Predicted integral membrane protein [Function unknown]; Region: COG5616 266835019862 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 266835019863 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 266835019864 cofactor binding site; other site 266835019865 DNA binding site [nucleotide binding] 266835019866 substrate interaction site [chemical binding]; other site 266835019867 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 266835019868 Helix-turn-helix domain; Region: HTH_36; pfam13730 266835019869 Transcription antiterminator [Transcription]; Region: NusG; COG0250 266835019870 N-Utilization Substance G (NusG) N-terminal (NGN) domain Superfamily; Region: NGN; cd08000 266835019871 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 266835019872 heterodimer interface [polypeptide binding]; other site 266835019873 homodimer interface [polypeptide binding]; other site 266835019874 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 266835019875 active site 266835019876 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 266835019877 DNA binding residues [nucleotide binding] 266835019878 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 266835019879 Phage-related protein [Function unknown]; Region: COG4695 266835019880 Phage portal protein; Region: Phage_portal; pfam04860 266835019881 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 266835019882 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 266835019883 oligomer interface [polypeptide binding]; other site 266835019884 active site residues [active] 266835019885 Predicted phage phi-C31 gp36 major capsid-like protein [General function prediction only]; Region: COG4653 266835019886 Phage capsid family; Region: Phage_capsid; pfam05065 266835019887 Homeodomain-like domain; Region: HTH_23; cl17451 266835019888 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 266835019889 active site 266835019890 catalytic triad [active] 266835019891 oxyanion hole [active] 266835019892 Lysozyme family protein [General function prediction only]; Region: zliS; COG3926 266835019893 Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838 266835019894 Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374 266835019895 Protein of unknown function (DUF1515); Region: DUF1515; pfam07439 266835019896 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 266835019897 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835019898 NAD(P) binding site [chemical binding]; other site 266835019899 active site 266835019900 Methyltransferase domain; Region: Methyltransf_31; pfam13847 266835019901 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266835019902 S-adenosylmethionine binding site [chemical binding]; other site 266835019903 Predicted membrane protein [Function unknown]; Region: COG2246 266835019904 GtrA-like protein; Region: GtrA; pfam04138 266835019905 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 266835019906 Ligand binding site; other site 266835019907 Putative Catalytic site; other site 266835019908 DXD motif; other site 266835019909 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266835019910 dimerization interface [polypeptide binding]; other site 266835019911 putative DNA binding site [nucleotide binding]; other site 266835019912 putative Zn2+ binding site [ion binding]; other site 266835019913 Inorganic pyrophosphatase [Energy production and conversion]; Region: Ppa; COG0221 266835019914 dimer interface [polypeptide binding]; other site 266835019915 substrate binding site [chemical binding]; other site 266835019916 metal binding sites [ion binding]; metal-binding site 266835019917 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 266835019918 classical (c) SDRs; Region: SDR_c; cd05233 266835019919 NAD(P) binding site [chemical binding]; other site 266835019920 active site 266835019921 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 266835019922 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 266835019923 TM-ABC transporter signature motif; other site 266835019924 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 266835019925 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 266835019926 ligand binding site [chemical binding]; other site 266835019927 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 266835019928 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 266835019929 Walker A/P-loop; other site 266835019930 ATP binding site [chemical binding]; other site 266835019931 Q-loop/lid; other site 266835019932 ABC transporter signature motif; other site 266835019933 Walker B; other site 266835019934 D-loop; other site 266835019935 H-loop/switch region; other site 266835019936 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 266835019937 non-specific DNA interactions [nucleotide binding]; other site 266835019938 DNA binding site [nucleotide binding] 266835019939 sequence specific DNA binding site [nucleotide binding]; other site 266835019940 putative cAMP binding site [chemical binding]; other site 266835019941 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 266835019942 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 266835019943 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 266835019944 ectoine utilization protein EutD; Region: ectoine_eutD; TIGR02993 266835019945 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 266835019946 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 266835019947 active site 266835019948 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 266835019949 Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528 266835019950 putative PBP binding loops; other site 266835019951 dimer interface [polypeptide binding]; other site 266835019952 ABC-ATPase subunit interface; other site 266835019953 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 266835019954 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 266835019955 Walker A/P-loop; other site 266835019956 ATP binding site [chemical binding]; other site 266835019957 Q-loop/lid; other site 266835019958 ABC transporter signature motif; other site 266835019959 Walker B; other site 266835019960 D-loop; other site 266835019961 H-loop/switch region; other site 266835019962 NMT1/THI5 like; Region: NMT1; pfam09084 266835019963 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266835019964 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 266835019965 active site 266835019966 Transcriptional regulators [Transcription]; Region: FadR; COG2186 266835019967 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266835019968 DNA-binding site [nucleotide binding]; DNA binding site 266835019969 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 266835019970 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 266835019971 FAD binding domain; Region: FAD_binding_4; pfam01565 266835019972 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 266835019973 Peptidase family M23; Region: Peptidase_M23; pfam01551 266835019974 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 266835019975 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835019976 NAD(P) binding site [chemical binding]; other site 266835019977 active site 266835019978 Transposase; Region: DEDD_Tnp_IS110; pfam01548 266835019979 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 266835019980 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 266835019981 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 266835019982 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 266835019983 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 266835019984 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266835019985 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 266835019986 NAD(P) binding site [chemical binding]; other site 266835019987 active site 266835019988 Transcriptional regulator [Transcription]; Region: IclR; COG1414 266835019989 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 266835019990 Bacterial transcriptional regulator; Region: IclR; pfam01614 266835019991 MmgE/PrpD family; Region: MmgE_PrpD; pfam03972 266835019992 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 266835019993 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 266835019994 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 266835019995 active site 266835019996 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 266835019997 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 266835019998 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 266835019999 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266835020000 Walker A/P-loop; other site 266835020001 ATP binding site [chemical binding]; other site 266835020002 Q-loop/lid; other site 266835020003 ABC transporter signature motif; other site 266835020004 Walker B; other site 266835020005 D-loop; other site 266835020006 H-loop/switch region; other site 266835020007 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835020008 dimer interface [polypeptide binding]; other site 266835020009 conserved gate region; other site 266835020010 putative PBP binding loops; other site 266835020011 ABC-ATPase subunit interface; other site 266835020012 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 266835020013 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835020014 dimer interface [polypeptide binding]; other site 266835020015 conserved gate region; other site 266835020016 putative PBP binding loops; other site 266835020017 ABC-ATPase subunit interface; other site 266835020018 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 266835020019 Amidase; Region: Amidase; cl11426 266835020020 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 266835020021 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 266835020022 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 266835020023 hydroxyglutarate oxidase; Provisional; Region: PRK11728 266835020024 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 266835020025 DDE superfamily endonuclease; Region: DDE_3; pfam13358 266835020026 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 266835020027 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 266835020028 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 266835020029 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 266835020030 catalytic residues [active] 266835020031 catalytic nucleophile [active] 266835020032 Presynaptic Site I dimer interface [polypeptide binding]; other site 266835020033 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 266835020034 Synaptic Flat tetramer interface [polypeptide binding]; other site 266835020035 Synaptic Site I dimer interface [polypeptide binding]; other site 266835020036 DNA binding site [nucleotide binding] 266835020037 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 266835020038 DNA-binding interface [nucleotide binding]; DNA binding site 266835020039 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 266835020040 Transposase; Region: DDE_Tnp_ISL3; pfam01610 266835020041 Transcriptional regulators [Transcription]; Region: GntR; COG1802 266835020042 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266835020043 DNA-binding site [nucleotide binding]; DNA binding site 266835020044 FCD domain; Region: FCD; pfam07729 266835020045 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 266835020046 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 266835020047 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 266835020048 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 266835020049 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 266835020050 Uncharacterized conserved protein [Function unknown]; Region: COG3246 266835020051 short chain dehydrogenase; Provisional; Region: PRK12829 266835020052 classical (c) SDRs; Region: SDR_c; cd05233 266835020053 NAD(P) binding site [chemical binding]; other site 266835020054 active site 266835020055 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 266835020056 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_3; cd06336 266835020057 putative ligand binding site [chemical binding]; other site 266835020058 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 266835020059 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 266835020060 TM-ABC transporter signature motif; other site 266835020061 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 266835020062 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 266835020063 TM-ABC transporter signature motif; other site 266835020064 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 266835020065 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 266835020066 Walker A/P-loop; other site 266835020067 ATP binding site [chemical binding]; other site 266835020068 Q-loop/lid; other site 266835020069 ABC transporter signature motif; other site 266835020070 Walker B; other site 266835020071 D-loop; other site 266835020072 H-loop/switch region; other site 266835020073 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 266835020074 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 266835020075 Walker A/P-loop; other site 266835020076 ATP binding site [chemical binding]; other site 266835020077 Q-loop/lid; other site 266835020078 ABC transporter signature motif; other site 266835020079 Walker B; other site 266835020080 D-loop; other site 266835020081 H-loop/switch region; other site 266835020082 Predicted thioesterase [General function prediction only]; Region: FcbC; COG0824 266835020083 active site 2 [active] 266835020084 active site 1 [active] 266835020085 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 266835020086 Transposase; Region: DEDD_Tnp_IS110; pfam01548 266835020087 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 266835020088 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 266835020089 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 266835020090 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 266835020091 Transposase; Region: DEDD_Tnp_IS110; pfam01548 266835020092 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 266835020093 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 266835020094 Transcriptional regulators [Transcription]; Region: GntR; COG1802 266835020095 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266835020096 DNA-binding site [nucleotide binding]; DNA binding site 266835020097 FCD domain; Region: FCD; pfam07729 266835020098 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 266835020099 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 266835020100 acyl-activating enzyme (AAE) consensus motif; other site 266835020101 AMP binding site [chemical binding]; other site 266835020102 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 266835020103 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 266835020104 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 266835020105 active site 266835020106 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 266835020107 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 266835020108 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 266835020109 putative NADP binding site [chemical binding]; other site 266835020110 active site 266835020111 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 266835020112 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 266835020113 Integrase core domain; Region: rve; pfam00665 266835020114 DDE domain; Region: DDE_Tnp_IS240; pfam13610 266835020115 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 266835020116 DNA methylase; Region: N6_N4_Mtase; pfam01555 266835020117 Restriction endonuclease; Region: Mrr_cat; pfam04471 266835020118 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 266835020119 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 266835020120 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 266835020121 Integrase core domain; Region: rve; pfam00665 266835020122 WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996 266835020123 Uncharacterized conserved protein [Function unknown]; Region: COG5642 266835020124 putative toxin-antitoxin system antitoxin component, TIGR02293 family; Region: TAS_TIGR02293 266835020125 Uncharacterized conserved protein [Function unknown]; Region: COG5654 266835020126 Predicted transcriptional regulator [Transcription]; Region: COG4957 266835020127 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 266835020128 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 266835020129 hexamer interface [polypeptide binding]; other site 266835020130 ligand binding site [chemical binding]; other site 266835020131 putative active site [active] 266835020132 NAD(P) binding site [chemical binding]; other site 266835020133 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 266835020134 tetramerization interface [polypeptide binding]; other site 266835020135 active site 266835020136 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK05963 266835020137 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 266835020138 dimer interface [polypeptide binding]; other site 266835020139 active site 266835020140 CoA binding pocket [chemical binding]; other site 266835020141 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964 266835020142 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 266835020143 inhibitor-cofactor binding pocket; inhibition site 266835020144 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266835020145 catalytic residue [active] 266835020146 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 266835020147 AAA domain; Region: AAA_26; pfam13500 266835020148 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 266835020149 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 266835020150 catalytic residue [active] 266835020151 biotin synthase; Region: bioB; TIGR00433 266835020152 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 266835020153 FeS/SAM binding site; other site 266835020154 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 266835020155 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK06106 266835020156 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 266835020157 dimerization interface [polypeptide binding]; other site 266835020158 active site 266835020159 L-aspartate oxidase; Provisional; Region: PRK07512 266835020160 L-aspartate oxidase; Provisional; Region: PRK06175 266835020161 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 266835020162 quinolinate synthetase; Provisional; Region: PRK09375 266835020163 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 266835020164 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 266835020165 DNA-binding site [nucleotide binding]; DNA binding site 266835020166 RNA-binding motif; other site 266835020167 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 266835020168 Uncharacterized conserved protein [Function unknown]; Region: COG3025 266835020169 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 266835020170 putative active site [active] 266835020171 putative metal binding residues [ion binding]; other site 266835020172 signature motif; other site 266835020173 putative triphosphate binding site [ion binding]; other site 266835020174 CHAD domain; Region: CHAD; pfam05235 266835020175 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 266835020176 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 266835020177 tetramer interface [polypeptide binding]; other site 266835020178 active site 266835020179 Mg2+/Mn2+ binding site [ion binding]; other site 266835020180 aspartate aminotransferase; Provisional; Region: PRK05764 266835020181 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 266835020182 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266835020183 homodimer interface [polypeptide binding]; other site 266835020184 catalytic residue [active] 266835020185 Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055 266835020186 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 266835020187 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 266835020188 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266835020189 homodimer interface [polypeptide binding]; other site 266835020190 catalytic residue [active] 266835020191 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 266835020192 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 266835020193 active site 266835020194 metal-binding site 266835020195 Domain of unknown function (DUF4372); Region: DUF4372; pfam14294 266835020196 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 266835020197 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 266835020198 active site 266835020199 non-prolyl cis peptide bond; other site 266835020200 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 266835020201 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 266835020202 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 266835020203 Ligand Binding Site [chemical binding]; other site 266835020204 Molecular Tunnel; other site 266835020205 Domain of unknown function (DUF4392); Region: DUF4392; pfam14336 266835020206 Integrase core domain; Region: rve; pfam00665 266835020207 Uncharacterized conserved protein [Function unknown]; Region: COG3535 266835020208 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 266835020209 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 266835020210 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 266835020211 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 266835020212 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266835020213 Walker A/P-loop; other site 266835020214 ATP binding site [chemical binding]; other site 266835020215 Q-loop/lid; other site 266835020216 ABC transporter signature motif; other site 266835020217 Walker B; other site 266835020218 D-loop; other site 266835020219 H-loop/switch region; other site 266835020220 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 266835020221 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 266835020222 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266835020223 Walker A/P-loop; other site 266835020224 ATP binding site [chemical binding]; other site 266835020225 Q-loop/lid; other site 266835020226 ABC transporter signature motif; other site 266835020227 Walker B; other site 266835020228 D-loop; other site 266835020229 H-loop/switch region; other site 266835020230 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 266835020231 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 266835020232 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835020233 dimer interface [polypeptide binding]; other site 266835020234 conserved gate region; other site 266835020235 putative PBP binding loops; other site 266835020236 ABC-ATPase subunit interface; other site 266835020237 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 266835020238 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835020239 dimer interface [polypeptide binding]; other site 266835020240 conserved gate region; other site 266835020241 putative PBP binding loops; other site 266835020242 ABC-ATPase subunit interface; other site 266835020243 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 266835020244 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 266835020245 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 266835020246 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266835020247 DNA binding residues [nucleotide binding] 266835020248 dimerization interface [polypeptide binding]; other site 266835020249 cystathionine beta-lyase; Provisional; Region: PRK07050 266835020250 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 266835020251 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 266835020252 catalytic residue [active] 266835020253 Uncharacterized component of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: COG3709 266835020254 Guanylate kinase; Region: Guanylate_kin; pfam00625 266835020255 active site 266835020256 putative phosphonate metabolism protein; Region: Phn_opern_protn; TIGR03223 266835020257 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 266835020258 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835020259 dimer interface [polypeptide binding]; other site 266835020260 conserved gate region; other site 266835020261 putative PBP binding loops; other site 266835020262 ABC-ATPase subunit interface; other site 266835020263 nickel transporter permease NikB; Provisional; Region: PRK10352 266835020264 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835020265 dimer interface [polypeptide binding]; other site 266835020266 conserved gate region; other site 266835020267 putative PBP binding loops; other site 266835020268 ABC-ATPase subunit interface; other site 266835020269 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 266835020270 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266835020271 Walker A/P-loop; other site 266835020272 ATP binding site [chemical binding]; other site 266835020273 Q-loop/lid; other site 266835020274 ABC transporter signature motif; other site 266835020275 Walker B; other site 266835020276 D-loop; other site 266835020277 H-loop/switch region; other site 266835020278 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 266835020279 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 266835020280 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266835020281 Walker A/P-loop; other site 266835020282 ATP binding site [chemical binding]; other site 266835020283 Q-loop/lid; other site 266835020284 ABC transporter signature motif; other site 266835020285 Walker B; other site 266835020286 D-loop; other site 266835020287 H-loop/switch region; other site 266835020288 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 266835020289 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 266835020290 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 266835020291 active site 266835020292 metal binding site [ion binding]; metal-binding site 266835020293 hexamer interface [polypeptide binding]; other site 266835020294 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 266835020295 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_10; cd08515 266835020296 ABC-type phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PhnL; COG4778 266835020297 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266835020298 Walker A/P-loop; other site 266835020299 ATP binding site [chemical binding]; other site 266835020300 Q-loop/lid; other site 266835020301 ABC transporter signature motif; other site 266835020302 Walker B; other site 266835020303 D-loop; other site 266835020304 H-loop/switch region; other site 266835020305 phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701 266835020306 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266835020307 Walker A/P-loop; other site 266835020308 ATP binding site [chemical binding]; other site 266835020309 Q-loop/lid; other site 266835020310 ABC transporter signature motif; other site 266835020311 Walker B; other site 266835020312 D-loop; other site 266835020313 H-loop/switch region; other site 266835020314 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 266835020315 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnJ; COG3627 266835020316 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnI; COG3626 266835020317 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnH; COG3625 266835020318 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnG; COG3624 266835020319 Metal-dependent hydrolase involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: COG3454 266835020320 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 266835020321 PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306 266835020322 active site 266835020323 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 266835020324 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266835020325 DNA-binding site [nucleotide binding]; DNA binding site 266835020326 UTRA domain; Region: UTRA; pfam07702 266835020327 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 266835020328 Glycerophosphodiester phosphodiesterase domain of Agrobacterium tumefaciens and similar proteins; Region: GDPD_AtGDE_like; cd08566 266835020329 putative active site [active] 266835020330 catalytic site [active] 266835020331 putative metal binding site [ion binding]; other site 266835020332 oligomer interface [polypeptide binding]; other site 266835020333 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 266835020334 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 266835020335 Transposase; Region: DEDD_Tnp_IS110; pfam01548 266835020336 Protein of unknown function (DUF3624); Region: DUF3624; pfam12292 266835020337 PAN/APPLE-like domain; present in N-terminal (N) domains of plasminogen/ hepatocyte growth factor proteins, plasma prekallikrein/coagulation factor XI and microneme antigen proteins, plant receptor-like protein kinases, and various nematode and leech...; Region: PAN_APPLE; cl00112 266835020338 Subfamily of PAN/APPLE-like domains; present in plasma prekallikrein/coagulation factor XI, microneme antigen proteins, and a few prokaryotic proteins. PAN/APPLE domains fulfill diverse biological functions by mediating protein-protein or...; Region: APPLE_Factor_XI_like; cd01100 266835020339 putative binding site; other site 266835020340 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 266835020341 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 266835020342 Subfamily of PAN/APPLE-like domains; present in plasma prekallikrein/coagulation factor XI, microneme antigen proteins, and a few prokaryotic proteins. PAN/APPLE domains fulfill diverse biological functions by mediating protein-protein or...; Region: APPLE_Factor_XI_like; cd01100 266835020343 putative binding site; other site 266835020344 PAN/APPLE-like domain; present in N-terminal (N) domains of plasminogen/ hepatocyte growth factor proteins, plasma prekallikrein/coagulation factor XI and microneme antigen proteins, plant receptor-like protein kinases, and various nematode and leech...; Region: PAN_APPLE; cl00112 266835020345 putative binding site; other site 266835020346 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 266835020347 TPP-binding site [chemical binding]; other site 266835020348 Uncharacterized protein conserved in bacteria, putative virulence factor [Function unknown]; Region: SrfC; COG4458 266835020349 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 266835020350 Walker A motif; other site 266835020351 ATP binding site [chemical binding]; other site 266835020352 Uncharacterized protein conserved in bacteria, putative virulence factor [Function unknown]; Region: SrfB; COG4457 266835020353 Sec23/Sec24 helical domain; Region: Sec23_helical; pfam04815 266835020354 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 266835020355 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 266835020356 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 266835020357 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266835020358 DNA binding residues [nucleotide binding] 266835020359 dimerization interface [polypeptide binding]; other site 266835020360 Protein of unknown function (DUF2384); Region: DUF2384; cl17718 266835020361 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 266835020362 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 266835020363 active site 266835020364 non-prolyl cis peptide bond; other site 266835020365 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 266835020366 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 266835020367 Walker A/P-loop; other site 266835020368 ATP binding site [chemical binding]; other site 266835020369 Q-loop/lid; other site 266835020370 ABC transporter signature motif; other site 266835020371 Walker B; other site 266835020372 D-loop; other site 266835020373 H-loop/switch region; other site 266835020374 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 266835020375 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835020376 dimer interface [polypeptide binding]; other site 266835020377 conserved gate region; other site 266835020378 putative PBP binding loops; other site 266835020379 ABC-ATPase subunit interface; other site 266835020380 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 266835020381 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 266835020382 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 266835020383 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266835020384 metal binding site [ion binding]; metal-binding site 266835020385 active site 266835020386 I-site; other site 266835020387 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 266835020388 Protein of unknown function (DUF982); Region: DUF982; pfam06169 266835020389 prevent-host-death family protein; Region: phd_fam; TIGR01552 266835020390 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain [Transcription]; Region: COG3609 266835020391 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 266835020392 putative oxidoreductase; Provisional; Region: PRK08275 266835020393 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 266835020394 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 266835020395 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 266835020396 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 266835020397 Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cl02500 266835020398 protein binding surface [polypeptide binding]; other site 266835020399 Transposase; Region: DEDD_Tnp_IS110; pfam01548 266835020400 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 266835020401 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 266835020402 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 266835020403 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 266835020404 putative switch regulator; other site 266835020405 non-specific DNA interactions [nucleotide binding]; other site 266835020406 DNA binding site [nucleotide binding] 266835020407 sequence specific DNA binding site [nucleotide binding]; other site 266835020408 putative cAMP binding site [chemical binding]; other site 266835020409 D-amino acid dehydrogenase small subunit; Provisional; Region: PRK12409 266835020410 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 266835020411 hydroxyglutarate oxidase; Provisional; Region: PRK11728 266835020412 Uncharacterized protein, possibly involved in utilization of glycolate and propanediol [General function prediction only]; Region: GlcG; COG3193 266835020413 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 266835020414 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 266835020415 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 266835020416 active site 266835020417 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 266835020418 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 266835020419 substrate-cofactor binding pocket; other site 266835020420 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266835020421 catalytic residue [active] 266835020422 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 266835020423 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 266835020424 homodimer interface [polypeptide binding]; other site 266835020425 substrate-cofactor binding pocket; other site 266835020426 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266835020427 catalytic residue [active] 266835020428 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 266835020429 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 266835020430 metal binding site [ion binding]; metal-binding site 266835020431 putative dimer interface [polypeptide binding]; other site 266835020432 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 266835020433 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_6; cd12165 266835020434 putative ligand binding site [chemical binding]; other site 266835020435 NAD binding site [chemical binding]; other site 266835020436 dimer interface [polypeptide binding]; other site 266835020437 putative catalytic site [active] 266835020438 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 266835020439 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 266835020440 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 266835020441 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835020442 dimer interface [polypeptide binding]; other site 266835020443 conserved gate region; other site 266835020444 ABC-ATPase subunit interface; other site 266835020445 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 266835020446 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 266835020447 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835020448 dimer interface [polypeptide binding]; other site 266835020449 conserved gate region; other site 266835020450 ABC-ATPase subunit interface; other site 266835020451 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 266835020452 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266835020453 Walker A/P-loop; other site 266835020454 ATP binding site [chemical binding]; other site 266835020455 Q-loop/lid; other site 266835020456 ABC transporter signature motif; other site 266835020457 Walker B; other site 266835020458 D-loop; other site 266835020459 H-loop/switch region; other site 266835020460 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 266835020461 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266835020462 Walker A/P-loop; other site 266835020463 ATP binding site [chemical binding]; other site 266835020464 Q-loop/lid; other site 266835020465 ABC transporter signature motif; other site 266835020466 Walker B; other site 266835020467 D-loop; other site 266835020468 H-loop/switch region; other site 266835020469 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 266835020470 Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055 266835020471 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 266835020472 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 266835020473 active site 266835020474 non-prolyl cis peptide bond; other site 266835020475 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 266835020476 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 266835020477 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 266835020478 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 266835020479 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266835020480 DNA-binding site [nucleotide binding]; DNA binding site 266835020481 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 266835020482 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266835020483 homodimer interface [polypeptide binding]; other site 266835020484 catalytic residue [active] 266835020485 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 266835020486 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 266835020487 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266835020488 dimerization interface [polypeptide binding]; other site 266835020489 putative DNA binding site [nucleotide binding]; other site 266835020490 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 266835020491 putative Zn2+ binding site [ion binding]; other site 266835020492 AsnC family; Region: AsnC_trans_reg; pfam01037 266835020493 argininosuccinate lyase; Provisional; Region: PRK02186 266835020494 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 266835020495 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 266835020496 active sites [active] 266835020497 tetramer interface [polypeptide binding]; other site 266835020498 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 266835020499 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 266835020500 dimer interface [polypeptide binding]; other site 266835020501 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266835020502 catalytic residue [active] 266835020503 Protein involved in propanediol utilization, and related proteins (includes coumermycin biosynthetic protein), possible kinase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduX; COG4542 266835020504 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 266835020505 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 266835020506 Integrase core domain; Region: rve; pfam00665 266835020507 Integrase core domain; Region: rve; pfam00665 266835020508 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266835020509 non-specific DNA binding site [nucleotide binding]; other site 266835020510 salt bridge; other site 266835020511 sequence-specific DNA binding site [nucleotide binding]; other site 266835020512 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 266835020513 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 266835020514 generic binding surface I; other site 266835020515 hypothetical protein; Provisional; Region: PRK06518 266835020516 Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525 266835020517 Catalytic site; other site 266835020518 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 266835020519 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 266835020520 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266835020521 sequence-specific DNA binding site [nucleotide binding]; other site 266835020522 salt bridge; other site 266835020523 Protein of unknown function (DUF1173); Region: DUF1173; pfam06666 266835020524 Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525 266835020525 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 266835020526 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 266835020527 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 266835020528 N-acetyl-D-glucosamine binding site [chemical binding]; other site 266835020529 catalytic residue [active] 266835020530 Type IV secretory pathway, VirB2 components (pilins) [Intracellular trafficking and secretion]; Region: VirB2; COG3838 266835020531 Type IV secretory pathway, VirB3 components [Intracellular trafficking and secretion]; Region: VirB3; COG3702 266835020532 Type IV secretory pathway, VirB4 components [Intracellular trafficking and secretion]; Region: VirB4; COG3451 266835020533 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 266835020534 Type IV secretory pathway, VirB6 components [Intracellular trafficking and secretion]; Region: VirB6; COG3704 266835020535 Type IV secretory pathway, component VirB8 [Intracellular trafficking and secretion]; Region: VirB8; COG3736 266835020536 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 266835020537 VirB7 interaction site; other site 266835020538 Type IV secretory pathway, VirB10 components [Intracellular trafficking and secretion]; Region: VirB10; COG2948 266835020539 P-type DNA transfer ATPase VirB11; Region: VirB11; TIGR02788 266835020540 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 266835020541 Walker A motif; other site 266835020542 hexamer interface [polypeptide binding]; other site 266835020543 ATP binding site [chemical binding]; other site 266835020544 Walker B motif; other site 266835020545 Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505 266835020546 The TraG/TraD/VirD4 family are bacterial conjugation proteins involved in type IV secretion. These proteins aid the transfer of DNA from the plasmid into the host bacterial chromosome. They contain an ATP binding domain. VirD4 is involved in DNA transfer...; Region: TraG_VirD4; cd01126 266835020547 Walker A motif; other site 266835020548 ATP binding site [chemical binding]; other site 266835020549 Walker B motif; other site 266835020550 putative addiction module antidote protein, CC2985 family; Region: antidote_CC2985; TIGR02606 266835020551 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 266835020552 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 266835020553 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 266835020554 catalytic residues [active] 266835020555 catalytic nucleophile [active] 266835020556 Presynaptic Site I dimer interface [polypeptide binding]; other site 266835020557 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 266835020558 Synaptic Flat tetramer interface [polypeptide binding]; other site 266835020559 Synaptic Site I dimer interface [polypeptide binding]; other site 266835020560 DNA binding site [nucleotide binding] 266835020561 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 266835020562 DNA-binding interface [nucleotide binding]; DNA binding site 266835020563 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 266835020564 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 266835020565 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 266835020566 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 266835020567 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_10; cd08515 266835020568 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_10; cd08515 266835020569 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 266835020570 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 266835020571 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266835020572 Walker A/P-loop; other site 266835020573 ATP binding site [chemical binding]; other site 266835020574 Q-loop/lid; other site 266835020575 ABC transporter signature motif; other site 266835020576 Walker B; other site 266835020577 D-loop; other site 266835020578 H-loop/switch region; other site 266835020579 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 266835020580 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 266835020581 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266835020582 Walker A/P-loop; other site 266835020583 ATP binding site [chemical binding]; other site 266835020584 Q-loop/lid; other site 266835020585 ABC transporter signature motif; other site 266835020586 Walker B; other site 266835020587 D-loop; other site 266835020588 H-loop/switch region; other site 266835020589 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 266835020590 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 266835020591 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835020592 dimer interface [polypeptide binding]; other site 266835020593 conserved gate region; other site 266835020594 putative PBP binding loops; other site 266835020595 ABC-ATPase subunit interface; other site 266835020596 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 266835020597 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835020598 dimer interface [polypeptide binding]; other site 266835020599 conserved gate region; other site 266835020600 putative PBP binding loops; other site 266835020601 ABC-ATPase subunit interface; other site 266835020602 Uncharacterized proteins of the AP superfamily [General function prediction only]; Region: COG1524 266835020603 Sulfatase; Region: Sulfatase; cl17466 266835020604 Metal-dependent hydrolase involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: COG3454 266835020605 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 266835020606 PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306 266835020607 active site 266835020608 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnG; COG3624 266835020609 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnH; COG3625 266835020610 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnI; COG3626 266835020611 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnJ; COG3627 266835020612 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266835020613 Walker A/P-loop; other site 266835020614 ATP binding site [chemical binding]; other site 266835020615 ABC transporter; Region: ABC_tran; pfam00005 266835020616 Q-loop/lid; other site 266835020617 ABC transporter signature motif; other site 266835020618 Walker B; other site 266835020619 D-loop; other site 266835020620 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 266835020621 ABC-type phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PhnL; COG4778 266835020622 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266835020623 Walker A/P-loop; other site 266835020624 ATP binding site [chemical binding]; other site 266835020625 Q-loop/lid; other site 266835020626 ABC transporter signature motif; other site 266835020627 Walker B; other site 266835020628 D-loop; other site 266835020629 H-loop/switch region; other site 266835020630 putative phosphonate metabolism protein; Region: Phn_opern_protn; TIGR03223 266835020631 Uncharacterized component of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: COG3709 266835020632 Guanylate kinase; Region: Guanylate_kin; pfam00625 266835020633 active site 266835020634 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 266835020635 DDE superfamily endonuclease; Region: DDE_3; pfam13358 266835020636 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266835020637 binding surface 266835020638 TPR motif; other site 266835020639 TPR repeat; Region: TPR_11; pfam13414 266835020640 TPR repeat; Region: TPR_11; pfam13414 266835020641 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266835020642 binding surface 266835020643 TPR motif; other site 266835020644 TPR repeat; Region: TPR_11; pfam13414 266835020645 Type IV secretory pathway, VirD2 components (relaxase) [Intracellular trafficking and secretion]; Region: VirD2; COG3843 266835020646 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 266835020647 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 266835020648 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 266835020649 P-loop; other site 266835020650 Magnesium ion binding site [ion binding]; other site 266835020651 WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996 266835020652 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4487 266835020653 Uncharacterized protein conserved in bacteria (DUF2130); Region: DUF2130; pfam09903 266835020654 Uncharacterized conserved protein [Function unknown]; Region: COG5489 266835020655 Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227 266835020656 Domain of unknown function (DUF1738); Region: DUF1738; pfam08401 266835020657 Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227 266835020658 Domain of unknown function (DUF1738); Region: DUF1738; pfam08401 266835020659 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 266835020660 plasmid partitioning protein; Provisional; Region: PRK13832 266835020661 ParB-like nuclease domain; Region: ParB; smart00470 266835020662 Cold shock proteins [Transcription]; Region: CspC; COG1278 266835020663 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 266835020664 DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646 266835020665 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 266835020666 pAE1 and related integrases, DNA breaking-rejoining enzymes, integrase/recombinases, C-terminal domain. This CD includes various bacterial integrases, including the predicted integrase of the deletion-prone region of plasmid pAE1 of Alcaligenes eutrophus...; Region: INT_pAE1; cd01188 266835020667 Int/Topo IB signature motif; other site 266835020668 INT_SG4, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 4, N- and C-terminal domains. The CD contains mainly predicted bacterial integrase/recombinases for which not much biochemical characterization is available; Region: INT_SG4; cd01187 266835020669 Int/Topo IB signature motif; other site 266835020670 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 266835020671 INT_SG5, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 5, N- and C-terminal domains. The CD contains mainly predicted bacterial integrase/recombinases; Region: INT_SG5; cd01190 266835020672 Int/Topo IB signature motif; other site 266835020673 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 266835020674 Putative transposase; Region: Y2_Tnp; pfam04986 266835020675 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 266835020676 IntI (E2) integrases, site-specific tyrosine recombinases, DNA breaking-rejoining enzymes, N- and C-terminal domains. This CD includes integrases which are components of multiresistant integrons and mediate recombination between a proximal attI site and...; Region: INT_IntI; cd01193 266835020677 Int/Topo IB signature motif; other site 266835020678 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 266835020679 INT_SG5, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 5, N- and C-terminal domains. The CD contains mainly predicted bacterial integrase/recombinases; Region: INT_SG5; cd01190 266835020680 Int/Topo IB signature motif; other site 266835020681 INT_SG4, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 4, N- and C-terminal domains. The CD contains mainly predicted bacterial integrase/recombinases for which not much biochemical characterization is available; Region: INT_SG4; cd01187 266835020682 Int/Topo IB signature motif; other site 266835020683 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 266835020684 pAE1 and related integrases, DNA breaking-rejoining enzymes, integrase/recombinases, C-terminal domain. This CD includes various bacterial integrases, including the predicted integrase of the deletion-prone region of plasmid pAE1 of Alcaligenes eutrophus...; Region: INT_pAE1; cd01188 266835020685 Int/Topo IB signature motif; other site 266835020686 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 266835020687 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266835020688 S-adenosylmethionine binding site [chemical binding]; other site 266835020689 DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646 266835020690 DEAD-like helicases superfamily; Region: DEXDc; smart00487 266835020691 Protein of unknown function (DUF3085); Region: DUF3085; pfam11284 266835020692 Protein of unknown function (DUF1419); Region: DUF1419; pfam07215 266835020693 Protein of unknown function (DUF3991); Region: DUF3991; pfam13154 266835020694 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cd00188 266835020695 active site 266835020696 metal binding site [ion binding]; metal-binding site 266835020697 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 266835020698 oligomerisation interface [polypeptide binding]; other site 266835020699 mobile loop; other site 266835020700 roof hairpin; other site 266835020701 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 266835020702 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 266835020703 ring oligomerisation interface [polypeptide binding]; other site 266835020704 ATP/Mg binding site [chemical binding]; other site 266835020705 stacking interactions; other site 266835020706 hinge regions; other site 266835020707 Chromosome segregation and condensation protein B [DNA replication, recombination and repair]; Region: scpB; COG1386 266835020708 Protein of unknown function (DUF1403); Region: DUF1403; pfam07183 266835020709 Protein of unknown function (DUF1403); Region: DUF1403; pfam07183 266835020710 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 266835020711 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266835020712 Walker A motif; other site 266835020713 ATP binding site [chemical binding]; other site 266835020714 Walker B motif; other site 266835020715 arginine finger; other site 266835020716 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 266835020717 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 266835020718 S-adenosylmethionine binding site [chemical binding]; other site 266835020719 replication initiation protein RepC; Provisional; Region: PRK13824 266835020720 Replication protein C N-terminal domain; Region: RP-C; pfam03428 266835020721 Replication protein C C-terminal region; Region: RP-C_C; pfam11800 266835020722 plasmid partitioning protein RepB; Region: partition_RepB; TIGR03454 266835020723 ParB-like nuclease domain; Region: ParBc; pfam02195 266835020724 plasmid partitioning protein RepA; Region: partition_RepA; TIGR03453 266835020725 MerR family regulatory protein; Region: MerR; pfam00376 266835020726 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 266835020727 P-loop; other site 266835020728 Magnesium ion binding site [ion binding]; other site 266835020729 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 266835020730 Magnesium ion binding site [ion binding]; other site 266835020731 Cre recombinase, C-terminal catalytic domain. Cre-like recombinases belong to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The bacteriophage P1 Cre...; Region: INT_Cre; cd00799 266835020732 DNA binding site [nucleotide binding] 266835020733 dimer interface [polypeptide binding]; other site 266835020734 Int/Topo IB signature motif; other site 266835020735 active site 266835020736 PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871 266835020737 putative active site [active] 266835020738 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4423 266835020739 Protein of unknown function (DUF1403); Region: DUF1403; pfam07183 266835020740 Chromosome segregation and condensation protein B [DNA replication, recombination and repair]; Region: scpB; COG1386 266835020741 TniQ; Region: TniQ; pfam06527 266835020742 Integrase core domain; Region: rve; pfam00665 266835020743 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 266835020744 Protein of unknown function (DUF1612); Region: DUF1612; pfam07756 266835020745 HTH DNA binding domain; Region: HTH_13; pfam11972 266835020746 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196 266835020747 ATP binding site [chemical binding]; other site 266835020748 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 266835020749 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 266835020750 active site 266835020751 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 266835020752 dimer interface [polypeptide binding]; other site 266835020753 substrate binding site [chemical binding]; other site 266835020754 catalytic residues [active] 266835020755 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 266835020756 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 266835020757 active site pocket [active] 266835020758 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417 266835020759 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 266835020760 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266835020761 non-specific DNA binding site [nucleotide binding]; other site 266835020762 salt bridge; other site 266835020763 sequence-specific DNA binding site [nucleotide binding]; other site 266835020764 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 266835020765 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 266835020766 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 266835020767 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 266835020768 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 266835020769 active site 266835020770 imidazolonepropionase; Validated; Region: PRK09356 266835020771 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 266835020772 active site 266835020773 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 266835020774 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 266835020775 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 266835020776 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266835020777 Walker A/P-loop; other site 266835020778 ATP binding site [chemical binding]; other site 266835020779 Q-loop/lid; other site 266835020780 ABC transporter signature motif; other site 266835020781 Walker B; other site 266835020782 D-loop; other site 266835020783 H-loop/switch region; other site 266835020784 TOBE domain; Region: TOBE_2; pfam08402 266835020785 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 266835020786 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835020787 dimer interface [polypeptide binding]; other site 266835020788 conserved gate region; other site 266835020789 putative PBP binding loops; other site 266835020790 ABC-ATPase subunit interface; other site 266835020791 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 266835020792 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 266835020793 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 266835020794 MmgE/PrpD family; Region: MmgE_PrpD; pfam03972 266835020795 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 266835020796 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835020797 dimer interface [polypeptide binding]; other site 266835020798 conserved gate region; other site 266835020799 putative PBP binding loops; other site 266835020800 ABC-ATPase subunit interface; other site 266835020801 Predicted TIM-barrel enzyme, possibly a dioxygenase [General function prediction only]; Region: COG5564 266835020802 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266835020803 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 266835020804 Walker A motif; other site 266835020805 ATP binding site [chemical binding]; other site 266835020806 Walker B motif; other site 266835020807 arginine finger; other site 266835020808 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 266835020809 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 266835020810 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 266835020811 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 266835020812 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 266835020813 TIM-barrel signal transduction protein; Region: TIM-br_sig_trns; pfam09370 266835020814 Uncharacterized conserved protein [Function unknown]; Region: COG5441 266835020815 Uncharacterized protein family (UPF0261); Region: UPF0261; pfam06792 266835020816 Predicted TIM-barrel enzyme, possibly a dioxygenase [General function prediction only]; Region: COG5564 266835020817 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 266835020818 hypothetical protein; Validated; Region: PRK08238 266835020819 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 266835020820 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 266835020821 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 266835020822 Response regulator receiver domain; Region: Response_reg; pfam00072 266835020823 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266835020824 active site 266835020825 phosphorylation site [posttranslational modification] 266835020826 intermolecular recognition site; other site 266835020827 dimerization interface [polypeptide binding]; other site 266835020828 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 266835020829 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266835020830 metal binding site [ion binding]; metal-binding site 266835020831 active site 266835020832 I-site; other site 266835020833 chemotaxis-specific methylesterase; Provisional; Region: PRK12555 266835020834 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266835020835 active site 266835020836 phosphorylation site [posttranslational modification] 266835020837 intermolecular recognition site; other site 266835020838 CheB methylesterase; Region: CheB_methylest; pfam01339 266835020839 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 266835020840 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 266835020841 putative binding surface; other site 266835020842 active site 266835020843 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266835020844 ATP binding site [chemical binding]; other site 266835020845 Mg2+ binding site [ion binding]; other site 266835020846 G-X-G motif; other site 266835020847 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 266835020848 Response regulator receiver domain; Region: Response_reg; pfam00072 266835020849 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266835020850 active site 266835020851 phosphorylation site [posttranslational modification] 266835020852 intermolecular recognition site; other site 266835020853 dimerization interface [polypeptide binding]; other site 266835020854 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588 266835020855 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 266835020856 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 266835020857 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266835020858 binding surface 266835020859 TPR motif; other site 266835020860 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 266835020861 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 266835020862 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 266835020863 dimerization interface [polypeptide binding]; other site 266835020864 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 266835020865 dimer interface [polypeptide binding]; other site 266835020866 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 266835020867 putative CheW interface [polypeptide binding]; other site 266835020868 Predicted membrane protein [Function unknown]; Region: COG2860 266835020869 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 266835020870 DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779 266835020871 active site 266835020872 DNA binding site [nucleotide binding] 266835020873 The Oligonucleotide/oligosaccharide binding (OB)-fold domain is a DNA-binding module that is part of the catalytic core unit of ATP dependent DNA ligases; Region: OBF_DNA_ligase_family; cl08424 266835020874 DNA binding site [nucleotide binding] 266835020875 Protein of unknown function (DUF768); Region: DUF768; pfam05589 266835020876 Protein of unknown function (DUF768); Region: DUF768; pfam05589 266835020877 Protein of unknown function (DUF768); Region: DUF768; pfam05589 266835020878 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 266835020879 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 266835020880 Int/Topo IB signature motif; other site 266835020881 DNA binding site [nucleotide binding] 266835020882 active site 266835020883 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 266835020884 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266835020885 putative DNA binding site [nucleotide binding]; other site 266835020886 putative Zn2+ binding site [ion binding]; other site 266835020887 AsnC family; Region: AsnC_trans_reg; pfam01037 266835020888 Pyruvate dehydrogenase complex, dehydrogenase (E1) component [Energy production and conversion]; Region: AceE; COG2609 266835020889 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 266835020890 dimer interface [polypeptide binding]; other site 266835020891 TPP-binding site [chemical binding]; other site 266835020892 dimer interface [polypeptide binding]; other site 266835020893 PYR/PP interface [polypeptide binding]; other site 266835020894 TPP binding site [chemical binding]; other site 266835020895 Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861 266835020896 Protein involved in propanediol utilization, and related proteins (includes coumermycin biosynthetic protein), possible kinase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduX; COG4542 266835020897 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 266835020898 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 266835020899 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 266835020900 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266835020901 catalytic residue [active] 266835020902 dimer interface [polypeptide binding]; other site 266835020903 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 266835020904 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 266835020905 homodimer interface [polypeptide binding]; other site 266835020906 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266835020907 catalytic residue [active] 266835020908 LuxR family transcriptional regulatory, chaperone HchA-associated; Region: reg_near_HchA; TIGR03541 266835020909 Autoinducer binding domain; Region: Autoind_bind; pfam03472 266835020910 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266835020911 DNA binding residues [nucleotide binding] 266835020912 dimerization interface [polypeptide binding]; other site 266835020913 N-acyl-L-homoserine lactone synthetase [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: LasI; COG3916 266835020914 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 266835020915 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 266835020916 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 266835020917 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237 266835020918 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470 266835020919 active site 266835020920 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 266835020921 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 266835020922 catalytic residues [active] 266835020923 catalytic nucleophile [active] 266835020924 Recombinase; Region: Recombinase; pfam07508 266835020925 RepB plasmid partitioning protein; Region: RepB; pfam07506 266835020926 Protein of unknown function (DUF768); Region: DUF768; pfam05589 266835020927 ATP-dependent DNA ligase [DNA replication, recombination, and repair]; Region: CDC9; COG1793 266835020928 Adenylation domain of proteins similar to ATP-dependent polynucleotide ligases; Region: Adenylation_DNA_ligase_like; cl12015 266835020929 Protein of unknown function (DUF3606); Region: DUF3606; pfam12244 266835020930 ATP-dependent DNA ligase [DNA replication, recombination, and repair]; Region: CDC9; COG1793 266835020931 Adenylation domain of proteins similar to ATP-dependent polynucleotide ligases; Region: Adenylation_DNA_ligase_like; cl12015 266835020932 Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; cl01261 266835020933 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 266835020934 DNA-binding site [nucleotide binding]; DNA binding site 266835020935 RNA-binding motif; other site 266835020936 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 266835020937 uncharacterized subgroup of the Escherichia coli Mg2+ transporter CorA_like subfamily; Region: EcCorA-like_u1; cd12837 266835020938 Cl binding site [ion binding]; other site 266835020939 oligomer interface [polypeptide binding]; other site 266835020940 PRC-barrel domain; Region: PRC; pfam05239 266835020941 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 266835020942 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 266835020943 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 266835020944 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 266835020945 Protein required for attachment to host cells [Cell motility and secretion]; Region: COG5622 266835020946 Protein of unknown function (DUF982); Region: DUF982; pfam06169 266835020947 PAS fold; Region: PAS_3; pfam08447 266835020948 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 266835020949 HWE histidine kinase; Region: HWE_HK; pfam07536 266835020950 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266835020951 active site 266835020952 phosphorylation site [posttranslational modification] 266835020953 intermolecular recognition site; other site 266835020954 dimerization interface [polypeptide binding]; other site 266835020955 Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380 266835020956 trehalose-6-phosphate synthase; Provisional; Region: PRK10117 266835020957 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 266835020958 homotetramer interface [polypeptide binding]; other site 266835020959 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 266835020960 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 266835020961 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 266835020962 PAS domain; Region: PAS_9; pfam13426 266835020963 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 266835020964 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 266835020965 HWE histidine kinase; Region: HWE_HK; pfam07536 266835020966 Protein of unknown function (DUF768); Region: DUF768; pfam05589 266835020967 Protein of unknown function (DUF2274); Region: DUF2274; pfam10038 266835020968 Type IV secretory pathway, VirB10 components [Intracellular trafficking and secretion]; Region: VirB10; COG2948 266835020969 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 266835020970 VirB7 interaction site; other site 266835020971 conjugal transfer protein TrbF; Provisional; Region: PRK13872 266835020972 conjugal transfer protein TrbL; Provisional; Region: PRK13875 266835020973 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503 266835020974 Conjugal transfer/entry exclusion protein [Intracellular trafficking and secretion]; Region: COG5314 266835020975 conjugal transfer protein TrbJ; Provisional; Region: PRK13874 266835020976 conjugal transfer ATPase TrbE; Provisional; Region: PRK13873 266835020977 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 266835020978 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 266835020979 Type IV secretory pathway, TrbD component [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TrbD; COG5268 266835020980 Type IV secretory pathway, VirB2 components (pilins) [Intracellular trafficking and secretion]; Region: VirB2; COG3838 266835020981 P-type conjugative transfer ATPase TrbB; Region: TrbB_P; TIGR02782 266835020982 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 266835020983 Walker A motif; other site 266835020984 ATP binding site [chemical binding]; other site 266835020985 Walker B motif; other site 266835020986 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 266835020987 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835020988 dimer interface [polypeptide binding]; other site 266835020989 conserved gate region; other site 266835020990 putative PBP binding loops; other site 266835020991 ABC-ATPase subunit interface; other site 266835020992 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 266835020993 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266835020994 dimer interface [polypeptide binding]; other site 266835020995 conserved gate region; other site 266835020996 putative PBP binding loops; other site 266835020997 ABC-ATPase subunit interface; other site 266835020998 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 266835020999 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 266835021000 Walker A/P-loop; other site 266835021001 ATP binding site [chemical binding]; other site 266835021002 Q-loop/lid; other site 266835021003 ABC transporter signature motif; other site 266835021004 Walker B; other site 266835021005 D-loop; other site 266835021006 H-loop/switch region; other site 266835021007 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 266835021008 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266835021009 DNA binding site [nucleotide binding] 266835021010 WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996 266835021011 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 266835021012 Ku-homolog [Replication, recombination, and repair]; Region: COG1273 266835021013 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 266835021014 putative DNA binding site [nucleotide binding]; other site 266835021015 putative homodimer interface [polypeptide binding]; other site 266835021016 Ku-homolog [Replication, recombination, and repair]; Region: COG1273 266835021017 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 266835021018 putative DNA binding site [nucleotide binding]; other site 266835021019 putative homodimer interface [polypeptide binding]; other site 266835021020 ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK05972 266835021021 DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777 266835021022 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 266835021023 active site 266835021024 DNA binding site [nucleotide binding] 266835021025 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 266835021026 DNA binding site [nucleotide binding] 266835021027 PaeLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: PaeLigD_Pol_like; cd04862 266835021028 nucleotide binding site [chemical binding]; other site 266835021029 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 266835021030 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 266835021031 putative dimer interface [polypeptide binding]; other site 266835021032 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211 266835021033 Predicted membrane protein [Function unknown]; Region: COG3336 266835021034 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 266835021035 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 266835021036 D-pathway; other site 266835021037 Putative ubiquinol binding site [chemical binding]; other site 266835021038 Low-spin heme (heme b) binding site [chemical binding]; other site 266835021039 Putative water exit pathway; other site 266835021040 Binuclear center (heme o3/CuB) [ion binding]; other site 266835021041 K-pathway; other site 266835021042 Putative proton exit pathway; other site 266835021043 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 266835021044 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 266835021045 Cytochrome c1 [Energy production and conversion]; Region: CYT1; COG2857 266835021046 Cytochrome c; Region: Cytochrom_C; pfam00034 266835021047 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 266835021048 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 266835021049 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 266835021050 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 266835021051 putative molybdopterin cofactor binding site [chemical binding]; other site 266835021052 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 266835021053 putative molybdopterin cofactor binding site; other site 266835021054 Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467 266835021055 SpoVR family protein; Provisional; Region: PRK11767 266835021056 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 266835021057 Uncharacterized conserved protein [Function unknown]; Region: COG2718 266835021058 PrkA family serine protein kinase; Provisional; Region: PRK15455 266835021059 AAA ATPase domain; Region: AAA_16; pfam13191 266835021060 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 266835021061 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 266835021062 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 266835021063 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 266835021064 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 266835021065 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 266835021066 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 266835021067 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051 266835021068 EF-hand domain pair; Region: EF_hand_5; pfam13499 266835021069 Ca2+ binding site [ion binding]; other site 266835021070 Chromosome segregation and condensation protein B [DNA replication, recombination and repair]; Region: scpB; COG1386 266835021071 Protein of unknown function (DUF1403); Region: DUF1403; pfam07183 266835021072 Uncharacterized conserved protein [Function unknown]; Region: COG5397 266835021073 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 266835021074 Cre recombinase, C-terminal catalytic domain. Cre-like recombinases belong to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The bacteriophage P1 Cre...; Region: INT_Cre; cd00799 266835021075 DNA binding site [nucleotide binding] 266835021076 dimer interface [polypeptide binding]; other site 266835021077 Int/Topo IB signature motif; other site 266835021078 active site 266835021079 Uncharacterized conserved protein [Function unknown]; Region: COG5654 266835021080 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 266835021081 replication initiation protein RepC; Provisional; Region: PRK13824 266835021082 Replication protein C N-terminal domain; Region: RP-C; pfam03428 266835021083 Replication protein C C-terminal region; Region: RP-C_C; pfam11800 266835021084 plasmid partitioning protein RepB; Region: partition_RepB; TIGR03454 266835021085 ParB-like nuclease domain; Region: ParB; smart00470 266835021086 plasmid partitioning protein RepA; Region: partition_RepA; TIGR03453 266835021087 MerR family regulatory protein; Region: MerR; pfam00376 266835021088 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 266835021089 P-loop; other site 266835021090 Magnesium ion binding site [ion binding]; other site 266835021091 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 266835021092 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 266835021093 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266835021094 putative active site [active] 266835021095 heme pocket [chemical binding]; other site 266835021096 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266835021097 putative active site [active] 266835021098 heme pocket [chemical binding]; other site 266835021099 PAS domain S-box; Region: sensory_box; TIGR00229 266835021100 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266835021101 putative active site [active] 266835021102 heme pocket [chemical binding]; other site 266835021103 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 266835021104 HWE histidine kinase; Region: HWE_HK; pfam07536 266835021105 PRC-barrel domain; Region: PRC; pfam05239 266835021106 PRC-barrel domain; Region: PRC; pfam05239 266835021107 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 266835021108 dimerization interface [polypeptide binding]; other site 266835021109 metal binding site [ion binding]; metal-binding site 266835021110 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 266835021111 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266835021112 active site 266835021113 phosphorylation site [posttranslational modification] 266835021114 intermolecular recognition site; other site 266835021115 dimerization interface [polypeptide binding]; other site 266835021116 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266835021117 DNA binding residues [nucleotide binding] 266835021118 dimerization interface [polypeptide binding]; other site 266835021119 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 266835021120 Protein of unknown function (DUF1236); Region: DUF1236; pfam06823 266835021121 Predicted small integral membrane protein [Function unknown]; Region: COG5478 266835021122 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 266835021123 putative active site [active] 266835021124 catalytic site [active] 266835021125 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 266835021126 PLD-like domain; Region: PLDc_2; pfam13091 266835021127 putative active site [active] 266835021128 catalytic site [active] 266835021129 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 266835021130 Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400 266835021131 putative active site [active] 266835021132 putative metal binding site [ion binding]; other site 266835021133 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 266835021134 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 266835021135 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 266835021136 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 266835021137 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 266835021138 active site 266835021139 RecA-superfamily ATPases implicated in signal transduction [Signal transduction mechanisms]; Region: RAD55; COG0467 266835021140 KaiC is a circadian clock protein primarily found in cyanobacteria KaiC is a RecA-like ATPase, having both Walker A and Walker B motifs. A related protein is found in archaea; Region: KaiC; cd01124 266835021141 Walker A motif; other site 266835021142 ATP binding site [chemical binding]; other site 266835021143 Walker B motif; other site 266835021144 KaiC; Region: KaiC; pfam06745 266835021145 KaiC is a circadian clock protein primarily found in cyanobacteria KaiC is a RecA-like ATPase, having both Walker A and Walker B motifs. A related protein is found in archaea; Region: KaiC; cd01124 266835021146 Walker A motif; other site 266835021147 ATP binding site [chemical binding]; other site 266835021148 Walker B motif; other site 266835021149 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 266835021150 HWE histidine kinase; Region: HWE_HK; pfam07536 266835021151 PAS domain; Region: PAS_8; pfam13188 266835021152 PAS domain; Region: PAS_9; pfam13426 266835021153 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 266835021154 Histidine kinase; Region: HisKA_2; pfam07568 266835021155 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266835021156 ATP binding site [chemical binding]; other site 266835021157 Mg2+ binding site [ion binding]; other site 266835021158 G-X-G motif; other site 266835021159 Protein required for attachment to host cells [Cell motility and secretion]; Region: COG5622 266835021160 ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224 266835021161 Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905 266835021162 active site 266835021163 DNA binding site [nucleotide binding] 266835021164 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970 266835021165 DNA binding site [nucleotide binding] 266835021166 Amidases related to nicotinamidase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PncA; COG1335 266835021167 Isochorismatase family; Region: Isochorismatase; pfam00857 266835021168 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 266835021169 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 266835021170 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 266835021171 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 266835021172 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 266835021173 Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227 266835021174 Domain of unknown function (DUF1738); Region: DUF1738; pfam08401 266835021175 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 266835021176 ParB-like nuclease domain; Region: ParBc; pfam02195 266835021177 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266835021178 S-adenosylmethionine binding site [chemical binding]; other site 266835021179 P-loop containing NTP hydrolase pore-1; Region: AAA_34; pfam13872 266835021180 Helicase_C-like; Region: Helicase_C_4; pfam13871 266835021181 Toprim domain; Region: Toprim_3; pfam13362 266835021182 Protein of unknown function (DUF2493); Region: DUF2493; pfam10686 266835021183 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 266835021184 active site 266835021185 DNA polymerase IV; Validated; Region: PRK02406 266835021186 DNA binding site [nucleotide binding] 266835021187 Uncharacterized conserved protein [Function unknown]; Region: COG2135 266835021188 Uncharacterized conserved protein [Function unknown]; Region: COG2135 266835021189 Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding [General function prediction only]; Region: COG5516 266835021190 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 266835021191 CGNR zinc finger; Region: zf-CGNR; pfam11706 266835021192 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 266835021193 EamA-like transporter family; Region: EamA; pfam00892 266835021194 EamA-like transporter family; Region: EamA; pfam00892 266835021195 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 266835021196 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 266835021197 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 266835021198 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 266835021199 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 266835021200 active site 266835021201 catalytic tetrad [active] 266835021202 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 266835021203 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 266835021204 acyl-activating enzyme (AAE) consensus motif; other site 266835021205 AMP binding site [chemical binding]; other site 266835021206 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 266835021207 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 266835021208 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 266835021209 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 266835021210 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 266835021211 active site 266835021212 Methyltransferase domain; Region: Methyltransf_31; pfam13847 266835021213 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266835021214 S-adenosylmethionine binding site [chemical binding]; other site 266835021215 Protein of unknown function (DUF768); Region: DUF768; pfam05589 266835021216 Uncharacterized conserved protein [Function unknown]; Region: COG5419 266835021217 Uncharacterized conserved protein [Function unknown]; Region: COG5419 266835021218 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 266835021219 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 266835021220 Uncharacterized conserved protein [Function unknown]; Region: COG5489 266835021221 Helix-turn-helix domain; Region: HTH_17; pfam12728 266835021222 Plasmid replication initiator protein [DNA replication, recombination, and repair]; Region: COG5534 266835021223 Protein of unknown function (DUF2840); Region: DUF2840; pfam11000 266835021224 Signal peptidase, peptidase S26; Region: Peptidase_S26; pfam10502 266835021225 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 266835021226 Uncharacterized conserved protein [Function unknown]; Region: COG5489 266835021227 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 266835021228 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 266835021229 N-acetyl-D-glucosamine binding site [chemical binding]; other site 266835021230 catalytic residue [active] 266835021231 Type IV secretory pathway, VirD2 components (relaxase) [Intracellular trafficking and secretion]; Region: VirD2; COG3843 266835021232 Protein of unknown function (DUF3363); Region: DUF3363; pfam11843 266835021233 conjugal transfer coupling protein TraG; Provisional; Region: PRK13876 266835021234 The TraG/TraD/VirD4 family are bacterial conjugation proteins involved in type IV secretion. These proteins aid the transfer of DNA from the plasmid into the host bacterial chromosome. They contain an ATP binding domain. VirD4 is involved in DNA transfer...; Region: TraG_VirD4; cd01126 266835021235 Walker A motif; other site 266835021236 ATP binding site [chemical binding]; other site 266835021237 Walker B motif; other site 266835021238 ectoine/hydroxyectoine ABC transporter solute-binding protein; Region: ectoine_ehuB; TIGR02995 266835021239 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 266835021240 substrate binding pocket [chemical binding]; other site 266835021241 membrane-bound complex binding site; other site 266835021242 hinge residues; other site 266835021243 Lysozyme family protein [General function prediction only]; Region: zliS; COG3926 266835021244 Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374 266835021245 Protein of unknown function (DUF1515); Region: DUF1515; pfam07439