-- dump date 20140619_134810 -- class Genbank::CDS -- table cds_note -- id note YP_002559318.1 similar to mobilization protein YP_002559319.1 no similarity YP_002559320.1 similar to functionally unknown protein YP_002559321.1 phage integrase family YP_002559322.1 similar to functionally unknown protein YP_002559323.1 similar to permease protein YP_002559324.1 similar to radical SAM domain protein YP_002559325.1 similar to molybdenum cofactor biosynthesis protein A YP_002559326.1 similar to bacteriocin adenylyltransferase YP_002559327.1 similar to transcriptional regulator, XRE family YP_002559330.1 no similarity YP_002559331.1 no similarity YP_002559332.1 no similarity YP_002559333.1 similar to functionally unknown protein YP_002559334.1 similar to functionally unknown protein YP_002559335.1 similar to ORF10 of B. anthracis plasmid pXO2 YP_002559336.1 similar to ORF9 of B. anthracis plasmid pXO2 YP_002559337.1 similar to functionally unknown protein YP_002559338.1 no similarity YP_002559339.1 similar to replication-associated protein YP_002559340.1 similar to functionally unknown protein YP_002559341.1 similar to ORF84 of B. anthracis plasmid pXO2 YP_002559342.1 no similarity YP_002559343.1 similar to functionally unknown protein YP_002559344.1 similar to DNA topoisomerase III TopB YP_002559345.1 similar to functionally unknown protein YP_002559346.1 similar to functionally unknown protein YP_002559347.1 similar to 5-methylcytosine-specific restriction enzyme MRR YP_002559348.1 no similarity YP_002559349.1 similar to sortase YP_002559352.1 similar to methicillin-resistance regulatory protein MecI YP_002559353.1 similar to methicillin resistance protein sensor transducer MecR1 YP_002559355.1 similar to beta-lactamase YP_002559358.1 similar to restriction endonuclease YP_002559359.1 no similarity YP_002559360.1 similar to functionally unknown protein YP_002559361.1 similar to functionally unknown protein YP_002559362.1 no similarity YP_002559363.1 integrase YP_002559364.1 no similarity YP_002559365.1 no similarity YP_002559367.1 no similarity YP_002559369.1 no similarity YP_002559370.1 similar to functionally unknown protein YP_002559372.1 kanamycin/gentamycin resistance determinant YP_002559373.1 erythromycin resistance determinant YP_002559377.1 no similarity YP_002559379.1 no similarity YP_002559382.1 similar to dihydrofolate reductase YP_002559383.1 similar to thymidylate synthase YP_002559384.1 similar to DNA repair protein RadC YP_002559385.1 no similarity YP_002559386.1 no similarity YP_002559387.1 similar to plasmid replication-associated protein YP_002559388.1 no similarity YP_002559390.1 no similarity YP_002559391.1 similar to functionally unknown protein YP_002559392.1 no similarity YP_002559393.1 no similarity YP_002559394.1 no similarity YP_002559395.1 similar to functionally unknown protein YP_002559396.1 similar to functionally unknown protein YP_002559397.1 similar to functionally unknown protein YP_002559398.1 similar to functionally unknown protein YP_002559399.1 no similarity YP_002559400.1 no similarity YP_002559403.1 similar to mobilization protein YP_002559405.1 binds the polymerase to DNA and acts as a sliding clamp YP_002559410.1 Required for DNA replication; binds preferentially to single-stranded, linear DNA YP_002559413.1 catalyzes the formation of 2-acetolactate from pyruvate in stationary phase YP_002559415.1 similar to functionally unknown protein YP_002559416.1 catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_002559417.1 similar to functionally unknown protein YP_002559418.1 similar to functionally unknown protein YP_002559419.1 similar to functionally unknown protein YP_002559420.1 in Escherichia coli this protein is wrapped around the base of the L1 stalk YP_002559422.1 catalyzes the formation of N6-(1,2,-dicarboxyethyl)-AMP from L-aspartate, inosine monophosphate and GTP in AMP biosynthesis YP_002559423.1 similar to functionally unknown protein YP_002559426.1 similar to functionally unknown protein YP_002559427.1 similar to functionally unknown protein YP_002559429.1 SPOUT methyltransferase family protein; crystal structure shows homodimer; in Escherichia coli this protein methylates pseudouridine at position 1915 of the 23S ribosomal RNA YP_002559430.1 similar to acetyltransferase YP_002559431.1 similar to functionally unknown protein YP_002559434.1 similar to ThiJ/PfpI family protein YP_002559435.1 similar to functionally unknown protein YP_002559436.1 similar to functionally unknown protein YP_002559437.1 similar to functionally unknown protein YP_002559438.1 similar to MutT/Nudix family protein YP_002559439.1 similar to functionally unknown protein YP_002559442.1 similar to functionally unknown protein YP_002559444.1 similar to sodium-dependent transporter YP_002559445.1 similar to functionally unknown protein YP_002559446.1 similar to functionally unknown protein YP_002559447.1 similar to NADPH-dependent FMN reductase YP_002559449.1 similar to functionally unknown protein YP_002559450.1 similar to functionally unknown protein YP_002559452.1 similar to functionally unknown protein YP_002559454.1 similar to general stress protein YP_002559455.1 similar to transcriptional regulator YP_002559456.1 similar to oxidoreductase family protein YP_002559458.1 similar to S. epidermidis secretory antigen SsaA YP_002559461.1 similar to 3-hydroxyacyl-CoA dehydrogenase YP_002559462.1 similar to homoserine O-succinyltransferase YP_002559464.1 no similarity YP_002559465.1 no similarity YP_002559468.1 no similarity YP_002559470.1 similar to functionally unknown protein YP_002559471.1 similar to cell-division inhibitor YP_002559472.1 similar to dioxygenase family protein YP_002559475.1 similar to functionally unknown protein YP_002559477.1 similar to functionally unknown protein YP_002559478.1 similar to transcriptional regulator, TetR family YP_002559479.1 in group A Streptococci this protein was found to cross react with anti myosin antibodies and may play a role in rheumatic fever YP_002559481.1 similar to carboxylesterase YP_002559482.1 similar to amino acid permease YP_002559484.1 similar to pyridoxamine 5'-phosphate oxidase YP_002559486.1 similar to functionally unknown protein YP_002559490.1 similar to ABC transporter permease YP_002559491.1 similar to two-component response regulator YP_002559492.1 similar to two-component sensor kinase protein YP_002559494.1 similar to functionally unknown protein YP_002559495.1 similar to functionally unknown protein YP_002559498.1 similar to ABC transporter ATP-binding protein YP_002559503.1 similar to molybdate transporter substrate-binding protein YP_002559504.1 similar to MFS Sugar transporter superfamily protein YP_002559505.1 similar to functionally unknown protein YP_002559506.1 similar to functionally unknown protein YP_002559507.1 similar to functionally unknown protein YP_002559508.1 similar to ABC transporter ATP-binding protein YP_002559509.1 FMN-dependent; requires NADH; catalyzes the cleavage of azo bond in aromatic azo compounds YP_002559510.1 similar to functionally unknown protein YP_002559511.1 similar to functionally unknown protein YP_002559512.1 similar to two-component sensor histidine kinase YP_002559513.1 similar to two-component response regulator YP_002559514.1 negatively regulates murein hydrolase activity YP_002559515.1 in conjunction with LrgA this protein inhibits the expression or activity of extracellular murein hydrolases YP_002559516.1 similar to ABC transporter permease YP_002559518.1 similar to functionally unknown protein YP_002559519.1 similar to functionally unknown protein YP_002559520.1 similar to molybdopterin biosynthesis protein moeB YP_002559521.1 functions in thiamine (vitamin B1) biosynthesis; in Bacillus subtilis this enzyme catalyzes the formation of thiazole from dehydroxyglycine and 1-deoxy-D-xylulose-5-phosphate and ThiS-thiocarboxylate YP_002559522.1 similar to glycine oxidase YP_002559524.1 no similarity YP_002559526.1 similar to functionally unknown protein YP_002559527.1 no similarity YP_002559530.1 similar to functionally unknown protein YP_002559533.1 similar to molybdate transporter permease YP_002559534.1 similar to functionally unknown protein YP_002559535.1 similar to transporter EamA family YP_002559537.1 similar to biotin biosynthesis BioY family protein YP_002559538.1 involved in the production or activity of formate dehydrogenase-H which is active when nitrate is not present during anaerobic growth YP_002559544.1 two-component sensor histidine kinase of nitrate reduction operon YP_002559546.1 no similarity YP_002559555.1 in Escherichia coli MobA links a guanosine 5'-phosphate to molydopterin to form molybdopterin guanine dinucleotide during molybdenum cofactor biosynthesis YP_002559558.1 no similarity YP_002559559.1 similar to transporter protein YP_002559560.1 similar to transcription regulator MarR family YP_002559562.1 similar to teicoplanin resistance associated membrane protein TcaB YP_002559567.1 similar to functionally unknown protein YP_002559568.1 similar to thioredoxin reductase YP_002559572.1 no similarity YP_002559574.1 similar to transcriptional regulator, GntR family YP_002559575.1 similar to Fe-S oxidoreductase YP_002559577.1 similar to functionally unknown protein YP_002559578.1 similar to functionally unknown protein YP_002559580.1 no similarity YP_002559582.1 similar to cation multidrug efflux pump YP_002559583.1 similar to aminotransferase family protein YP_002559584.1 similar to functionally unknown protein YP_002559585.1 similar to multidrug-efflux transporter YP_002559586.1 similar to functionally unknown protein YP_002559588.1 similar to functionally unknown protein YP_002559590.1 similar to glucose uptake protein YP_002559591.1 similar to functionally unknown protein YP_002559592.1 decatenates replicating daughter chromosomes YP_002559594.1 similar to functionally unknown protein YP_002559596.1 similar to functionally unknown protein YP_002559597.1 NusE; involved in assembly of the 30S subunit; in the ribosome, this protein is involved in the binding of tRNA; in Escherichia coli this protein was also found to be involved in transcription antitermination; NusB/S10 heterodimers bind boxA sequences in the leader RNA of rrn operons which is required for antitermination; binding of NusB/S10 to boxA nucleates assembly of the antitermination complex YP_002559598.1 binds directly near the 3' end of the 23S rRNA, where it nucleates assembly of the 50S subunit; essential for peptidyltransferase activity; mutations in this gene confer resistance to tiamulin YP_002559599.1 L4 is important during the early stages of 50S assembly; it initially binds near the 5' end of the 23S rRNA YP_002559600.1 binds third domain of 23S rRNA and protein L29; part of exit tunnel YP_002559601.1 one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation YP_002559603.1 binds specifically to 23S rRNA during the early stages of 50S assembly; makes contact with all 6 domains of the 23S rRNA in the assembled 50S subunit and ribosome; mutations in this gene result in erythromycin resistance; located near peptidyl-transferase center YP_002559604.1 forms a complex with S10 and S14; binds the lower part of the 30S subunit head and the mRNA in the complete ribosome to position it for translation YP_002559605.1 located in the peptidyl transferase center and may be involved in peptidyl transferase activity; similar to archaeal L10e YP_002559608.1 binds to the 23S rRNA between the centers for peptidyl transferase and GTPase YP_002559609.1 assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel YP_002559611.1 located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group appear to contain the zinc-binding motif YP_002559612.1 binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit YP_002559613.1 ribosomal protein L6 appears to have arisen as a result of an ancient gene duplication as based on structural comparison of the Bacillus stearothermophilus protein; RNA-binding appears to be in the C-terminal domain; mutations in the L6 gene confer resistance to aminoglycoside antibiotics such as gentamicin and these occur in truncations of the C-terminal domain; it has been localized to a region between the base of the L7/L12 stalk and the central protuberance YP_002559615.1 located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body; contacts S4 and S8; with S4 and S12 plays a role in translational accuracy; mutations in this gene result in spectinomycin resistance YP_002559616.1 L30 binds domain II of the 23S rRNA and the 5S rRNA; similar to eukaryotic protein L7 YP_002559618.1 forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase YP_002559619.1 essential enzyme that recycles AMP in active cells; converts ATP and AMP to two molecules of ADP YP_002559620.1 stimulates the activities of the other two initiation factors, IF-2 and IF-3 YP_002559621.1 smallest protein in the large subunit; similar to what is found with protein L31 and L33 several bacterial genomes contain paralogs which may be regulated by zinc; the protein from Thermus thermophilus has a zinc-binding motif and contains a bound zinc ion; the proteins in this group have the motif YP_002559622.1 located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA; makes contact with the large subunit via RNA-protein interactions and via protein-protein interactions with L5; contacts P-site tRNA YP_002559623.1 located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA; forms part of the Shine-Dalgarno cleft in the 70S ribosome; interacts with S7 and S18 and IF-3 YP_002559624.1 catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme YP_002559625.1 is a component of the macrolide binding site in the peptidyl transferase center YP_002559627.1 similar to ABC transporter ATP-binding protein YP_002559629.1 mediates pseudouridylation (positions 38, 39, 40) at the tRNA anticodon region which contributes to the structural stability YP_002559630.1 in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit YP_002559631.1 forms a direct contact with the tRNA during translation YP_002559632.1 similar to functionally unknown protein YP_002559634.1 no similarity YP_002559635.1 similar to ORF012 of Bacteriophage 37 YP_002559636.1 no similarity YP_002559639.1 similar to functionally unknown protein YP_002559640.1 most similar to IS30 family YP_002559641.1 similar to fusidic acid resistance protein YP_002559642.1 similar to functionally unknown protein YP_002559643.1 similar to functionally unknown protein YP_002559644.1 similar to functionally unknown protein YP_002559647.1 similar to functionally unknown protein YP_002559648.1 no similarity YP_002559650.1 similar to histone acetyltransferase HPA2 YP_002559651.1 similar to functionally unknown protein YP_002559653.1 similar to functionally unknown protein YP_002559655.1 similar to DNA mismatch repair protein MutS YP_002559656.1 no similarity YP_002559657.1 similar to ABC transporter substrate-binding protein YP_002559659.1 no similarity YP_002559660.1 similar to functionally unknown protein YP_002559662.1 similar to universal stress protein family YP_002559665.1 this stereospecific enzymes reduces the S isomer of methionine sulfoxide while MsrB reduces the R form; a fusion protein of this enzyme with MsrB provides protection against oxidative stress in Neisseria gonorrhoeae YP_002559668.1 similar to functionally unknown protein YP_002559669.1 similar to functionally unknown protein YP_002559671.1 similar to functionally unknown protein YP_002559672.1 similar to transcriptional regulator, MerR family protein YP_002559673.1 no similarity YP_002559674.1 similar to functionally unknown protein YP_002559675.1 similar to acetyltransferase family protein YP_002559676.1 similar to chloramphenicol resistance protein YP_002559677.1 similar to functionally unknown protein YP_002559678.1 similar to functionally unknown protein YP_002559679.1 similar to functionally unknown protein YP_002559682.1 similar to endonuclease/exonuclease/phosphatase family protein YP_002559686.1 similar to ABC transporter permease YP_002559687.1 similar to cadmium transporting P-type ATPase YP_002559688.1 similar to cAMP-binding proteins, regulatory subunit of cAMP-dependent protein kinases YP_002559689.1 catalyzes the formation of phosphoenolpyruvate from pyruvate YP_002559690.1 similar to functionally unknown protein YP_002559692.1 similar to divalent cation transporter YP_002559693.1 similar to functionally unknown protein YP_002559696.1 similar to sensor histidine kinase YP_002559697.1 similar to two-component response regulator YP_002559698.1 similar to murein hydrolase exporter YP_002559699.1 similar to effector of murein hydrolase YP_002559700.1 no similarity YP_002559702.1 similar to functionally unknown protein YP_002559703.1 similar to DNA-3-methyladenine glycosidase YP_002559704.1 similar to chloramphenicol resistance protein YP_002559705.1 similar to acetyltransferase YP_002559706.1 similar to functionally unknown protein YP_002559707.1 similar to functionally unknown protein YP_002559708.1 similar to short-chain dehydrogenase/reductase YP_002559709.1 similar to cyanate transporter YP_002559710.1 similar to chloramphenicol-sensitive protein rarD YP_002559711.1 no similarity YP_002559712.1 similar to functionally unknown protein YP_002559713.1 similar to UTP--glucose-1-phosphate uridylyltransferase YP_002559714.1 similar to functionally unknown protein YP_002559715.1 similar to functionally unknown protein YP_002559716.1 similar to functionally unknown protein YP_002559717.1 converts 1,4-alpha-D-glucans to maltodextrin YP_002559719.1 similar to signaling pathway activation protein KinB YP_002559720.1 similar to permease of major facilitator superfamily YP_002559723.1 similar to transcriptional regulator, ArsR family YP_002559724.1 similar to functionally unknown protein YP_002559725.1 similar to functionally unknown protein YP_002559726.1 catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate YP_002559727.1 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source YP_002559729.1 similar to endonuclease III YP_002559730.1 similar to RecA/RadA recombinase family protein YP_002559731.1 no similarity YP_002559732.1 similar to amino acid permease YP_002559733.1 converts homocysteine and S-adenosyl-methionine to methionine and S-adenosyl-homocysteine or S-methyl-methionine and homocysteine to two methionines YP_002559734.1 similar to functionally unknown protein YP_002559735.1 similar to sugar kinase family protein YP_002559736.1 no similarity YP_002559737.1 similar to functionally unknown protein YP_002559738.1 similar to functionally unknown protein YP_002559739.1 similar to functionally unknown protein YP_002559740.1 similar to RNA-directed DNA polymerase YP_002559741.1 similar to phosphohydrolases, Icc family YP_002559742.1 similar to lactose phosphotransferase system repressor YP_002559745.1 similar to ABC transporter permease YP_002559746.1 similar to ABC transporter ATP-binding protein YP_002559747.1 catalyzes the formation of L-histidinol from L-histidinol phosphate YP_002559748.1 similar to ornithine cyclodeaminase YP_002559749.1 similar to functionally unknown protein YP_002559750.1 similar to transcriptional regulator, XRE family YP_002559751.1 similar to transcriptional repressor of ribose operon YP_002559753.1 no similarity YP_002559754.1 similar to aldose 1-epimerase YP_002559759.1 similar to transcriptional regulator YP_002559763.1 similar to functionally unknown protein YP_002559766.1 malate dehydrogenase; catalyzes the oxidation of malate to oxaloacetate YP_002559767.1 no similarity YP_002559768.1 similar to functionally unknown protein YP_002559769.1 similar to sortase YP_002559770.1 similar to sortase YP_002559771.1 similar to Mn2+/Fe2+ transporter YP_002559772.1 similar to carboxypeptidase YP_002559775.1 similar to transcriptional regulator YP_002559777.1 similar to fructokinase YP_002559779.1 catalyzes the formation of biotin from dethiobiotin and sulfur 2 S-adenosyl-L-methionine YP_002559780.1 similar to ATP-dependent DNA helicase RecQ YP_002559781.1 no similarity YP_002559782.1 similar to functionally unknown protein YP_002559783.1 similar to functionally unknown protein YP_002559784.1 similar to p-aminobenzoyl-glutamate transporter YP_002559785.1 similar to functionally unknown protein YP_002559787.1 similar to metallo-beta-lactamase superfamily protein YP_002559788.1 similar to pyrrolidone-carboxylate peptidase YP_002559789.1 similar to UbiE/COQ5 methyltransferase YP_002559790.1 malate dehydrogenase; catalyzes the oxidation of malate to oxaloacetate YP_002559791.1 similar to sodium dependent transporter YP_002559792.1 similar to functionally unknown protein YP_002559794.1 no similarity YP_002559795.1 similar to acetyltransferase, GNAT family protein YP_002559796.1 similar to O6-methylguanine-DNA methyltransferase YP_002559798.1 similar to functionally unknown protein YP_002559799.1 similar to functionally unknown protein YP_002559800.1 no similarity YP_002559802.1 similar to functionally unknown protein YP_002559804.1 similar to functionally unknown protein YP_002559805.1 similar to functionally unknown protein YP_002559807.1 similar to functionally unknown protein YP_002559811.1 similar to functionally unknown protein YP_002559812.1 similar to functionally unknown protein YP_002559813.1 similar to functionally unknown protein YP_002559814.1 similar to functionally unknown protein YP_002559815.1 similar to short-chain dehydrogenase/reductase SDR YP_002559816.1 similar to regulatory protein GntR YP_002559817.1 similar to ABC transporter ATP-binding protein YP_002559818.1 no similarity YP_002559819.1 similar to phospholipase D endonuclease domain protein YP_002559823.1 similar to transcriptional regulator YP_002559826.1 similar to functionally unknown protein YP_002559827.1 no similarity YP_002559829.1 similar to Mg-dependent DNase YP_002559831.1 similar to functionally unknown protein YP_002559832.1 similar to major facilitator superfamily protein YP_002559833.1 similar to functionally unknown protein YP_002559834.1 similar to functionally unknown protein YP_002559835.1 similar to sodium/hydrogen exchanger family protein YP_002559838.1 similar to acetyltransferase YP_002559839.1 similar to functionally unknown protein YP_002559840.1 no similarity YP_002559841.1 similar to functionally unknown protein YP_002559842.1 similar to secreted metal-dependent protease YP_002559843.1 similar to acetyltransferase, GNAT family YP_002559844.1 similar to functionally unknown protein YP_002559845.1 similar to acetyltransferase, GNAT family YP_002559846.1 similar to functionally unknown protein YP_002559847.1 similar to functionally unknown protein YP_002559848.1 similar to MarR family regulatory protein YP_002559849.1 BacA; phosphatase activity in Escherichia coli not kinase; involved in bacitracin resistance as bacitracin supposedly sequesters undecaprenyl disphosphate which reduces the pool of lipid carrier available to the cell YP_002559850.1 similar to MsbA family ABC transporter ATP-binding protein YP_002559851.1 similar to MsbA family ABC transporter ATP-binding protein YP_002559852.1 similar to degV family protein YP_002559854.1 similar to cobalamin synthesis P47K family protein YP_002559858.1 similar to alpha/beta hydrolase fold family protein YP_002559860.1 similar to functionally unknown protein YP_002559862.1 similar to functionally unknown protein YP_002559864.1 similar to functionally unknown protein YP_002559865.1 similar to functionally unknown protein YP_002559866.1 similar to radical activating enzyme family protein YP_002559869.1 similar to glutamine amidotransferase of anthranilate synthase YP_002559870.1 similar to anthranilate/para-aminobenzoate synthases component I YP_002559871.1 similar to functionally unknown protein YP_002559873.1 similar to divalent heavy-metal cations transporter YP_002559878.1 catalyzes the formation of L-histidinol phosphate from imidazole-acetol phosphate and glutamate in histidine biosynthesis YP_002559879.1 similar to 5'(3')-deoxyribonucleotidase YP_002559880.1 similar to multidrug resistance protein YP_002559881.1 similar to proton-dependent oligopeptide transport protein ue YP_002559884.1 similar to functionally unknown protein YP_002559885.1 in Salmonella NrdI has a stimulatory effect on the ribonucleotide reductase activity of NrdH with NrdEF YP_002559886.1 Catalyzes the rate-limiting step in dNTP synthesis YP_002559887.1 B2 or R2 protein; type 1b enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdE YP_002559888.1 similar to functionally unknown protein YP_002559889.1 catalyzes the reduction of UDP-N-acetylglucosamine enolpyruvate to form UDP-N-acetylmuramate in peptidoglycan biosynthesis YP_002559890.1 similar to functionally unknown protein YP_002559891.1 similar to functionally unknown protein YP_002559892.1 similar to functionally unknown protein YP_002559893.1 similar to glycerate kinase YP_002559895.1 similar to functionally unknown protein YP_002559896.1 similar to functionally unknown protein YP_002559897.1 similar to functionally unknown protein YP_002559898.1 similar to functionally unknown protein YP_002559900.1 similar to functionally unknown protein YP_002559902.1 similar to comF operon protein 1 YP_002559903.1 similar to late competence operon protein FC YP_002559905.1 functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond SecA1; SecA2 is not essential and seems to play a role in secretion of a subset of proteins YP_002559908.1 similar to invasion-associated protein p60 YP_002559909.1 similar to secretory antigen precursor SsaA YP_002559910.1 no similarity YP_002559911.1 similar to phosphohydrolase YP_002559912.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpin of the Uvr-B subunit is inserted between the strands, where it probes for the presence of a lesion YP_002559913.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate YP_002559914.1 catalyzes the phosphorylation of the phosphocarrier protein HPr of the bacterial phosphotransferase system YP_002559917.1 similar to functionally unknown protein YP_002559919.1 similar to functionally unknown protein YP_002559920.1 similar to functionally unknown protein YP_002559921.1 similar to functionally unknown protein YP_002559922.1 hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates YP_002559927.1 catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate YP_002559928.1 enolase; catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis YP_002559930.1 similar to carboxylesterase YP_002559933.1 similar to cell wall associated biofilm protein YP_002559934.1 similar to ORF012 of bacteriophage 88 YP_002559935.1 similar to 3-dehydroquinate dehydratase YP_002559936.1 similar to functionally unknown protein YP_002559938.1 similar to arsenate reductase YP_002559940.1 similar to functionally unknown protein YP_002559941.1 similar to thioredoxin YP_002559946.1 similar to functionally unknown protein YP_002559947.1 similar to selenocysteine lyase YP_002559951.1 similar to functionally unknown protein YP_002559952.1 similar to amino acid ABC transporter ATP-binding protein YP_002559953.1 similar to functionally unknown protein YP_002559954.1 similar to functionally unknown protein YP_002559955.1 similar to functionally unknown protein YP_002559956.1 catalyzes the radical-mediated insertion of two sulfur atoms into an acyl carrier protein (ACP) bound to an octanoyl group to produce a lipoyl group YP_002559957.1 similar to autolysis and methicillin resistant-related protein YP_002559958.1 similar to autolysis and methicillin resistant-related protein YP_002559959.1 similar to functionally unknown protein YP_002559960.1 similar to functionally unknown protein YP_002559961.1 similar to functionally unknown protein YP_002559963.1 transfers D-alanine to the D-alanyl carrier protein during the incorporation of D-alanine into lipoteichoic acid YP_002559966.1 similar to functionally unknown protein YP_002559968.1 similar to functionally unknown protein YP_002559969.1 similar to pyridine nucleotide-disulphide oxidoreductase YP_002559970.1 similar to mutT/nudix family protein YP_002559971.1 similar to functionally unknown protein YP_002559972.1 no similarity YP_002559973.1 similar to transporter YP_002559974.1 similar to ComA2 family protein YP_002559977.1 subunit E of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali YP_002559978.1 subunit D of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; contains an oxidoreductase domain; catalyzes the transfer of electrons from NADH to ubiquinone YP_002559981.1 subunit A of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali YP_002559982.1 similar to kinase-associated protein B YP_002559992.1 similar to functionally unknown protein YP_002559995.1 similar to ATP-dependent nuclease subunit A YP_002559996.1 no similarity YP_002559998.1 similar to functionally unknown protein YP_002559999.1 similar to alpha-amylase YP_002560000.1 NADPH-dependent; catalyzes the reduction of coenzyme A disulfide YP_002560001.1 similar to haloacid dehalogenase-like hydrolase YP_002560002.1 similar to functionally unknown protein YP_002560003.1 similar to ranscription regulatory protein Fnr YP_002560005.1 similar to transcriptional activator protein Med YP_002560013.1 catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_002560014.1 the anti-alpha factor Spx interacts with RNA polymerase alpha subunit C-terminal domain in a region that interacts with the sigma 70 subunit and may interfere with activation of promoters; in Bacillus subtilis this protein is a substrate for ClpXP protease; blocks transcription of the competence regulatory gene encoded by the srf operon; regulates a number of genes involved in thiol homeostasis including trxA and trxB; monomeric member of ArsC family of proteins; does not bind DNA; contains a disulfide bond between C10 and C13 which may sense disulfide stress YP_002560015.1 enables recognition and targeting of proteins for proteolysis, involved in negative regulation of competence YP_002560016.1 similar to functionally unknown protein YP_002560021.1 similar to functionally unknown protein YP_002560022.1 similar to functionally unknown protein YP_002560024.1 catalyzes the phosphorylation of NAD to NADP YP_002560028.1 Catalyzes a key regulatory step in fatty acid biosynthesis YP_002560029.1 similar to 2'-5' RNA ligase YP_002560030.1 similar to functionally unknown protein YP_002560031.1 similar to functionally unknown protein YP_002560032.1 similar to permease of the major facilitator superfamily YP_002560033.1 processive; catalyzes the formation of mono-, di- and tri-glucosyldiacylglycerol by the progressive transfer of glucosyl residues to diacylglycerol; involved in the formation of membrane glycolipids YP_002560034.1 involved in cell wall formation; peptidoglycan synthesis; cytoplasmic enzyme; catalyzes the addition of lysine to UDP-N-acetylmuramoyl-L-alanyl-D-glutamate forming UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysine YP_002560035.1 stimulates the release of release factors 1 and 2 from the ribosome after hydrolysis of the ester bond in peptidyl-tRNA has occurred; GDP/GTP-binding protein YP_002560037.1 similar to serine protease YP_002560039.1 similar to two-component sensor histidine kinase YP_002560040.1 similar to nucleotidase YP_002560041.1 similar to functionally unknown protein YP_002560042.1 similar to DNA-binding protein YP_002560043.1 no similarity YP_002560044.1 similar to peptidase YP_002560045.1 similar to functionally unknown protein YP_002560046.1 similar to bifunctional autolysin with amidase and hexosaminidase YP_002560047.1 similar to functionally unknown protein YP_002560048.1 similar to transcriptional regulator YP_002560051.1 similar to minor teichoic acid biosynthesis protein GgaB YP_002560053.1 with TagG is involved in the export of teichoic acids YP_002560055.1 similar to functionally unknown protein YP_002560056.1 similar to teichoic acid biosynthesis protein TagB YP_002560057.1 similar to teichoic acid biosynthesis protein tagX YP_002560058.1 similar to galactosamine-containing minor teichoic acid biosynthesis protein YP_002560060.1 similar to functionally unknown protein YP_002560063.1 similar to teichoic acid ABC transporter permease YP_002560064.1 no similarity YP_002560065.1 no similarity YP_002560066.1 no similarity YP_002560067.1 no similarity YP_002560068.1 similar to teichoic acids export ATP-binding protein tagH YP_002560069.1 similar to group 1 glycosyl transferase YP_002560070.1 no similarity YP_002560071.1 similar to capsular polysaccharide biosynthesis protein CapA YP_002560074.1 similar to capsular polysaccharide biosynthesis protein CapF YP_002560075.1 no similarity YP_002560076.1 similar to galactoside O-acetyltransferase YP_002560079.1 similar to capsular polysaccharide biosynthesis protein YP_002560080.1 similar to functionally unknown protein YP_002560082.1 predicted polysaccharide polymerase involved in biofilm formation; required for the synthesis of the beta-1,6-N-acetylglucosamine polysaccharide; PgaC; in Yersinia the HmsR protein is an inner membrane protein YP_002560083.1 similar to intercellular adhesion protein IcaD YP_002560084.1 similar to intercellular adhesion protein IcaB YP_002560085.1 similar to intercellular adhesion protein IcaC YP_002560086.1 similar to functionally unknown protein YP_002560087.1 similar to flavohemoprotein YP_002560088.1 similar to functionally unknown protein YP_002560089.1 catalyzes the formation of 5,10-methenyltetrahydrofolate from 5,10-methylenetetrahydrofolate and subsequent formation of 10-formyltetrahydrofolate from 5,10-methenyltetrahydrofolate YP_002560090.1 similar to phosphoribosylaminoimidazole carboxylase catalytic subunit YP_002560091.1 With PurE catalyzes the conversion of aminoimidazole ribonucleotide to carboxyaminoimidazole ribonucleotide in the de novo purine nucleotide biosynthetic pathway YP_002560092.1 catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis; SAICAR synthase YP_002560093.1 similar to functionally unknown protein YP_002560094.1 catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis YP_002560095.1 catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis YP_002560097.1 catalyzes the formation of 1-(5-phosphoribosyl)-5-aminoimidazole from 2-(formamido)-N1-(5-phosphoribosyl)acetamidine and ATP in purine biosynthesis YP_002560099.1 involved in de novo purine biosynthesis YP_002560101.1 similar to functionally unknown protein YP_002560102.1 similar to functionally unknown protein YP_002560103.1 similar to functionally unknown protein YP_002560105.1 similar to phosphoesterase YP_002560110.1 similar to HAD superfamily hydrolase YP_002560112.1 similar to functionally unknown protein YP_002560116.1 E3 component of pyruvate complex; catalyzes the oxidation of dihydrolipoamide to lipoamide YP_002560117.1 similar to functionally unknown protein YP_002560122.1 similar to functionally unknown protein YP_002560123.1 similar to functionally unknown protein YP_002560125.1 similar to functionally unknown protein YP_002560127.1 no similarity YP_002560130.1 similar to functionally unknown protein YP_002560132.1 biotin-containing enzyme that catalyzes a two step carboxylation of pyruvate to oxaloacetate YP_002560134.1 converts protoheme IX and farnesyl diphosphate to heme O YP_002560138.1 similar to cytochrome c oxidase, subunit IV YP_002560139.1 similar to CtaG protein YP_002560140.1 similar to functionally unknown protein YP_002560141.1 similar to functionally unknown protein YP_002560142.1 similar to functionally unknown protein YP_002560143.1 similar to functionally unknown protein YP_002560144.1 similar to functionally unknown protein YP_002560145.1 no similarity YP_002560146.1 similar to functionally unknown protein YP_002560147.1 similar to functionally unknown protein YP_002560148.1 similar to methylase YP_002560150.1 similar to functionally unknown protein YP_002560151.1 similar to functionally unknown protein YP_002560152.1 similar to functionally unknown protein YP_002560153.1 MraZ; UPF0040; crystal structure shows similarity to AbrB YP_002560157.1 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan YP_002560158.1 UDP-N-acetylmuramoylalanine--D-glutamate ligase; involved in peptidoglycan biosynthesis; cytoplasmic; catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine during cell wall formation YP_002560159.1 similar to cell division initiation protein ftsQ YP_002560161.1 GTPase; similar structure to tubulin; forms ring-shaped polymers at the site of cell division; other proteins such as FtsA, ZipA, and ZapA, interact with and regulate FtsZ function YP_002560162.1 similar to functionally unknown protein YP_002560163.1 similar to functionally unknown protein YP_002560165.1 similar to functionally unknown protein YP_002560167.1 IleRS; catalyzes the formation of isoleucyl-tRNA(Ile) from isoleucine and tRNA(Ile); since isoleucine and other amino acids such as valine are similar, there are additional editing function in this enzyme; one is involved in hydrolysis of activated valine-AMP and the other is involved in deacylation of mischarged Val-tRNA(Ile); there are two active sites, one for aminoacylation and one for editing; class-I aminoacyl-tRNA synthetase family type 1 subfamily; some organisms carry two different copies of this enzyme YP_002560169.1 lipoprotein signal peptidase; integral membrane protein that removes signal peptides from prolipoproteins during lipoprotein biosynthesis YP_002560170.1 similar to ribosomal large subunit psudouridine synthase D YP_002560171.1 regulates pyrimidine biosynthesis by binding to the mRNA of the pyr genes, also has been shown to have uracil phosphoribosyltransferase activity YP_002560174.1 catalyzes the formation of N-carbamoyl-L-aspartate from (S)-dihydroorotate in pyrimidine biosynthesis YP_002560175.1 catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers YP_002560176.1 four CarB-CarA dimers form the carbamoyl phosphate synthetase holoenzyme that catalyzes the production of carbamoyl phosphate; CarB is responsible for the amidotransferase activity YP_002560179.1 type 1 subfamily; involved in last step of pyrimidine biosynthesis; converts orotidine 5'-phosphate to UMP and carbon dioxide; OMP decarboxylase; OMPDCase; OMPdecase YP_002560180.1 involved in fifth step of pyrimidine biosynthesis; converts orotidine 5'-phosphate and diphosphate to orotate and 5-phospho-alpha-D-ribose 1-diphosphate YP_002560181.1 no similarity YP_002560184.1 similar to pullulanase YP_002560197.1 Essential for recycling GMP and indirectly, cGMP YP_002560202.1 similar to tRNA and rRNA cytosine-C5-methylase YP_002560203.1 23S rRNA m2A2503 methyltransferase; methylates the C2 position of the A2530 nucleotide in 23S rRNA; may be involved in antibiotic resistance YP_002560204.1 similar to protein phosphatase YP_002560205.1 similar to protein kinase YP_002560206.1 no similarity YP_002560207.1 similar to cytochrome P450 family protein YP_002560208.1 similar to functionally unknown protein YP_002560210.1 similar to functionally unknown protein YP_002560211.1 similar to functionally unknown protein YP_002560214.1 catalyzes branch migration in Holliday junction intermediates YP_002560215.1 similar to sortase YP_002560216.1 negative regulator of genes involved in fatty acid and phospholipid biosynthesis for gram positive bacteria YP_002560217.1 involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsY YP_002560220.1 cytoplasmic enzyme involved in processing rRNA and some mRNAs; substrates typically have dsRNA regions; forms a homodimer; have N-terminal nuclease and C-terminal RNA-binding domains; requires magnesium as preferred ion for activity YP_002560221.1 similar to chromosome segregation SMC protein YP_002560223.1 similar to functionally unknown protein YP_002560225.1 Essential for efficient processing of 16S rRNA YP_002560226.1 methylates guanosine-37 in various tRNAs; uses S-adenosyl-L-methionine to transfer methyl group to tRNA YP_002560228.1 similar to functionally unknown protein YP_002560229.1 similar to functionally unknown protein YP_002560230.1 similar to functionally unknown protein YP_002560232.1 essential GTPase; functions in ribosome assembly; binds a unique part of the 23S rRNA; interacts with ribosomal protein L25(Ctc) YP_002560234.1 catalyzes the interconversion of succinyl-CoA and succinate YP_002560236.1 similar to DNA processing Smf protein YP_002560237.1 catalyzes the ATP-dependent breakage of single-stranded DNA followed by passage and rejoining, maintains net negative superhelicity YP_002560238.1 TrmFO; Gid; glucose-inhibited division protein; similar to GidA; the gene from Bacillus subtilis encodes a tRNA-methyltransferase that utilizes folate as the carbon donor and bound flavin as reductant; modifies tRNA at position 54 (uridine) of the T-psi loop to form a C5-methyluridine YP_002560240.1 heat shock protein involved in degradation of misfolded proteins YP_002560241.1 heat shock protein involved in degradation of misfolded proteins YP_002560242.1 CodY; DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase (By similarity). It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor YP_002560243.1 one of the last subunits in the assembly of the 30S subunit; absence of S2 does not inhibit assembly but results in an inactive subunit YP_002560245.1 Catalyzes the phosphorylation of UMP to UDP YP_002560247.1 catalyzes the formation of undecaprenyl pyrophosphate from isopentenyl pyrophosphate YP_002560251.1 catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro) YP_002560252.1 catalyzes DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time; required for leading strand synthesis; PolC exhibits 3' to 5' exonuclease activity YP_002560253.1 in Streptococcus pneumoniae this gene was found to be essential; structure determination of the Streptococcus protein shows that it is similar to a number of other proteins YP_002560254.1 modifies transcription through interactions with RNA polymerase affecting elongation, readthrough, termination, and antitermination YP_002560255.1 similar to functionally unknown protein YP_002560256.1 Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex YP_002560257.1 similar to integrase/recombinase YP_002560260.1 catalyzes the formation of 2-oxobutanoate from L-threonine; biosynthetic YP_002560263.1 catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis YP_002560268.1 similar to zinc protease YP_002560269.1 similar to functionally unknown protein YP_002560271.1 similar to transcriptional regulator YP_002560272.1 similar to functionally unknown protein YP_002560273.1 similar to zinc protease YP_002560274.1 similar to short chain dehydrogenase YP_002560275.1 similar to functionally unknown protein YP_002560276.1 similar to transcriptional regulator YP_002560278.1 catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of ous single-stranded DNAs YP_002560279.1 protein from Staphylococcus aureus has phosphodiesterase activity against 2'-3'-cAMP and 2'-3'-cGMP YP_002560280.1 similar to functionally unknown protein YP_002560282.1 catalyzes the coenzyme A dependent formation of succinyl-CoA from 2-oxoglutarate and ferredoxin YP_002560284.1 similar to hydroxymethylpyrimidine transporter permease YP_002560285.1 similar to hydroxymethylpyrimidine transport ATP-binding protein YP_002560287.1 similar to ABC transporter ATP-binding protein YP_002560289.1 catalyzes the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine from N6-(dimethylallyl)adenosine (i(6)A) YP_002560290.1 similar to functionally unknown protein YP_002560291.1 This protein performs the mismatch recognition step during the DNA repair process YP_002560292.1 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. Promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex YP_002560297.1 similar to hydrolase YP_002560298.1 IPP transferase; isopentenyltransferase; involved in tRNA modification; in Escherichia coli this enzyme catalyzes the addition of a delta2-isopentenyl group from dimethylallyl diphosphate to the N6-nitrogen of adenosine adjacent to the anticodon of tRNA species that read codons starting with uracil; further tRNA modifications may occur; mutations in miaA result in defects in translation efficiency and fidelity YP_002560300.1 similar to functionally unknown protein YP_002560301.1 similar to functionally unknown protein YP_002560305.1 no similarity YP_002560306.1 no similarity YP_002560307.1 no similarity YP_002560308.1 similar to phage-related protein YP_002560311.1 no similarity YP_002560312.1 no similarity YP_002560313.1 similar to functionally unknown protein YP_002560314.1 no similarity YP_002560315.1 similar to ssDNA binding protein YP_002560316.1 similar to phage regulatory protein YP_002560317.1 similar to functionally unknown protein YP_002560318.1 similar to functionally unknown protein YP_002560319.1 similar to functionally unknown protein YP_002560320.1 no similarity YP_002560321.1 similar to phage RNA polymerase sigma factor-like protein YP_002560322.1 no similarity YP_002560323.1 similar to ORF027 of bacteriophage 96 YP_002560324.1 ORF009 of bacteriophage 96 YP_002560325.1 ORF003 of bacteriophage 187 YP_002560326.1 no similarity YP_002560327.1 no similarity YP_002560328.1 similar to ORF021 of bacteriophage 187 YP_002560329.1 ORF011 of Bacteriophage 187 YP_002560330.1 similar to phage-related protein YP_002560331.1 similar to phage-related protein YP_002560332.1 similar to phage-related protein YP_002560333.1 similar to phage-related protein YP_002560334.1 similar to ORF043 of bacteriophage 187 YP_002560335.1 similar to phage-related protein YP_002560336.1 similar to ORF001 of bacteriophage 187 YP_002560337.1 no similarity YP_002560338.1 no similarity YP_002560339.1 similar to holin YP_002560340.1 similar to phage amidase YP_002560342.1 similar to phage-related protein YP_002560343.1 similar to ORF013 of bacteriophage 53 YP_002560344.1 no similarity YP_002560345.1 similar to phage-related protein YP_002560346.1 similar to phage-related protein YP_002560347.1 no similarity YP_002560348.1 similar to phage-related DNA binding protein YP_002560349.1 similar to phage-related protein YP_002560350.1 similar to phage-related DNA binding protein YP_002560351.1 similar to phage-related protein YP_002560352.1 no similarity YP_002560353.1 similar to ORF014 of bacteriophage 187 YP_002560354.1 no similarity YP_002560356.1 no similarity YP_002560357.1 no similarity YP_002560358.1 no similarity YP_002560359.1 ORF17 of Staphylococcus phage K YP_002560360.1 similar to functionally unknown protein YP_002560361.1 no similarity YP_002560362.1 similar to phage-related DNA binding protein YP_002560364.1 similar to functionally unknown protein YP_002560365.1 similar to functionally unknown protein YP_002560366.1 similar to phage-related protein YP_002560367.1 similar to minor capsid protein YP_002560368.1 no similarity YP_002560369.1 no similarity YP_002560370.1 similar to functionally unknown protein YP_002560371.1 similar to functionally unknown protein YP_002560372.1 similar to functionally unknown protein YP_002560373.1 similar to functionally unknown protein YP_002560374.1 similar to functionally unknown protein YP_002560375.1 similar to functionally unknown protein YP_002560376.1 no similarity YP_002560377.1 no similarity YP_002560378.1 no similarity YP_002560379.1 no similarity YP_002560380.1 similar to ORF002 of bacteriophage 2638A YP_002560382.1 no similarity YP_002560383.1 no similarity YP_002560384.1 similar to ABC transporter ATP-binding protein YP_002560385.1 no similarity YP_002560386.1 similar to functionally unknown protein YP_002560387.1 catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP; lysine and threonine sensitive YP_002560390.1 similar to homoserine kinase YP_002560391.1 similar to functionally unknown protein YP_002560392.1 similar to functionally unknown protein YP_002560395.1 similar to Mn2+Zn2+ ABC transporter periplasmic substrate-binding protein YP_002560396.1 no similarity YP_002560397.1 similar to glyoxalase YP_002560398.1 Represses a number of genes involved in the response to DNA damage YP_002560399.1 similar to functionally unknown protein YP_002560401.1 no similarity YP_002560403.1 similar to functionally unknown protein YP_002560404.1 similar to functionally unknown protein YP_002560405.1 similar to exonuclease SbcD YP_002560406.1 similar to exonuclease SbcC YP_002560409.1 forms homopentamer; channel that opens in response to pressure or hypoosmotic shock YP_002560411.1 Catalyzes the conversion of citrate to isocitrate YP_002560412.1 similar to functionally unknown protein YP_002560413.1 similar to functionally unknown protein YP_002560414.1 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling YP_002560415.1 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling YP_002560417.1 similar to functionally unknown protein YP_002560418.1 similar to transcription antiterminator YP_002560420.1 similar to functionally unknown protein YP_002560421.1 similar to oxacillin resistance-related FmtC protein YP_002560422.1 this stereospecific enzymes reduces the S isomer of methionine sulfoxide while MsrB reduces the R form; provides protection against oxidative stress YP_002560425.1 similar to functionally unknown protein YP_002560426.1 similar to GCN5-related N-acetyltransferase YP_002560427.1 similar to functionally unknown protein YP_002560428.1 similar to functionally unknown protein YP_002560429.1 similar to mutator MutT protein YP_002560430.1 similar to functionally unknown protein YP_002560431.1 similar to functionally unknown protein YP_002560432.1 similar to functionally unknown protein YP_002560433.1 no similarity YP_002560434.1 similar to GNAT family acetyltransferase YP_002560435.1 similar to 6'-N-acetyltransferase YP_002560437.1 similar to ABC transporter ATP-binding protein YP_002560438.1 similar to ABC transporter substrate-binding protein YP_002560439.1 similar to permease YP_002560441.1 similar to intracellular protease/amidase YP_002560442.1 no similarity YP_002560443.1 no similarity YP_002560446.1 similar to functionally unknown protein YP_002560447.1 similar to oligoendopeptidase YP_002560448.1 similar to short-chain dehydrogenase/reductase SDR YP_002560449.1 similar to functionally unknown protein YP_002560451.1 catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP, in Bacillus, lysine sensitive; regulated by response to starvation. YP_002560453.1 catalyzes the formation of dihydrodipicolinate from L-aspartate 4-semialdehyde and pyruvate in lysine and diaminopimelate biosynthesis YP_002560454.1 catalyzes the reduction of 2,3-dihydrodipicolinate to 2,3,4,5-tetrahydrodipicolinate in lysine and diaminopimelate biosynthesis YP_002560459.1 similar to functionally unknown protein YP_002560460.1 similar to 5-bromo-4-chloroindolyl phosphate hydrolysis protein XpaC YP_002560463.1 similar to functionally unknown protein YP_002560465.1 similar to glyoxalase/bleomycin resistance protein YP_002560466.1 component of 2-oxoglutarate dehydrogenase complex; catalyzes the transfer of succinyl coenzyme A to form succinyl CoA as part of the conversion of 2-oxoglutarate to succinyl-CoA YP_002560467.1 SucA; E1 component of the oxoglutarate dehydrogenase complex which catalyzes the formation of succinyl-CoA from 2-oxoglutarate; SucA catalyzes the reaction of 2-oxoglutarate with dihydrolipoamide succinyltransferase-lipoate to form dihydrolipoamide succinyltransferase-succinyldihydrolipoate and carbon dioxide YP_002560470.1 similar to acetyltransferase, GNAT family YP_002560471.1 similar to functionally unknown protein YP_002560472.1 UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; involved in cell wall formation; inner membrane-associated; last step of peptidoglycan synthesis YP_002560473.1 similar to carboxypeptidase family protein YP_002560475.1 this stereospecific enzymes reduces the R isomer of methionine sulfoxide while MsrA reduces the S form; provides protection against oxidative stress YP_002560476.1 this stereospecific enzymes reduces the S isomer of methionine sulfoxide while MsrB reduces the R form; provides protection against oxidative stress YP_002560477.1 similar to functionally unknown protein YP_002560478.1 similar to functionally unknown protein YP_002560479.1 similar to 1-acyl-sn-glycerol-3-phosphate acyltransferase YP_002560481.1 ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived YP_002560482.1 no similarity YP_002560483.1 similar to functionally unknown protein YP_002560484.1 similar to functionally unknown protein YP_002560485.1 similar to functionally unknown protein YP_002560486.1 similar to functionally unknown protein YP_002560487.1 similar to functionally unknown protein YP_002560488.1 similar to functionally unknown protein YP_002560489.1 no similarity YP_002560490.1 similar to 5'-3' exonuclease YP_002560491.1 similar to thiosulfate sulfurtransferase YP_002560492.1 similar to functionally unknown protein YP_002560495.1 similar to monooxigenase YP_002560496.1 similar to methyltransferase YP_002560497.1 similar to functionally unknown protein YP_002560498.1 similar to functionally unknown protein YP_002560499.1 similar to functionally unknown protein YP_002560500.1 functions in ous recombination, DNA repair, and chromosome segregation; binds preferentially to three- and four-stranded DNA intermediates; introduces specific nick sites in four-stranded DNA substrates; functions similarly to Escherichia coli RuvC YP_002560502.1 similar to functionally unknown protein YP_002560505.1 catalyzes a two-step reaction, first charging an asparagine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_002560506.1 similar to ATP-dependent DNA helicase YP_002560507.1 similar to BirA bifunctional protein [includes: biotin operon repressor; biotin--[acetyl-CoA-carboxylase] synthetase] YP_002560508.1 similar to poly(A) polymerase YP_002560510.1 similar to pyrophosphatase YP_002560511.1 similar to functionally unknown protein YP_002560512.1 similar to functionally unknown protein YP_002560513.1 similar to functionally unknown protein YP_002560515.1 electron transport protein YP_002560517.1 similar to functionally unknown protein YP_002560518.1 similar to functionally unknown protein YP_002560519.1 similar to functionally unknown protein YP_002560520.1 catalyzes the formation of 5-O-(1-carboxyvinyl)-3-phosphoshikimate from phosphoenolpyruvate and 3-phosphoshikimate in tryptophan biosynthesis YP_002560521.1 catalyzes the formation of 3-dehydroquinate from 3-deoxy-arabino-heptulonate 7-phosphate; functions in aromatic amino acid biosynthesis YP_002560522.1 catalyzes the formation of chorismate from 5-O-(1-carboxyvinyl)-3-phosphoshikimate in aromatic amino acid biosynthesis YP_002560527.1 similar to functionally unknown protein YP_002560529.1 EngA; essential Neisserial GTPase; synchronizes cellular events by interacting with multiple targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide binding affinities in the two binding domains YP_002560530.1 in Escherichia coli this protein is involved in binding to the leader sequence of mRNAs and is itself bound to the 30S subunit; autoregulates expression via a C-terminal domain; in most gram negative organisms this protein is composed of 6 repeats of the S1 domain while in gram positive there are 4 repeats; the S1 nucleic acid-binding domain is found associated with other proteins YP_002560531.1 Catalyzes the formation of (d)CDP from ATP and (d)CMP YP_002560534.1 similar to functionally unknown protein YP_002560535.1 simlar to elastin binding protein YP_002560536.1 similar to ATP-dependent DNA helicase recQ YP_002560537.1 similar to functionally unknown protein YP_002560538.1 no similarity YP_002560539.1 similar to functionally unknown protein YP_002560540.1 similar to sensor kinase protein YP_002560546.1 similar to segregation and condensation protein B YP_002560547.1 similar to functionally unknown protein YP_002560548.1 similar to functionally unknown protein YP_002560553.1 similar to alpha/beta hydrolase YP_002560554.1 similar to short-chain dehydrogenase YP_002560556.1 similar to ribonuclease Z YP_002560557.1 catalyzes the formation of D-glucono-1,5-lactone 6-phosphate from D-glucose 6-phosphate YP_002560558.1 similar to functionally unknown protein YP_002560559.1 similar to transcriptional regulator, AraC family YP_002560562.1 similar to functionally unknown protein YP_002560563.1 similar to functionally unknown protein YP_002560565.1 similar to glycerophosphoryl diester phosphodiesterase YP_002560566.1 similar to response regulator receiver YP_002560568.1 regulates arginine biosynthesis when complexed with arginine by binding at site that overlap the promotors of the arginine biosynthesis genes YP_002560572.1 bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides YP_002560573.1 Regulates rRNA biosynthesis by transcriptional antitermination YP_002560574.1 similar to functionally unknown protein YP_002560575.1 an AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism YP_002560579.1 similar to functionally unknown protein YP_002560580.1 similar to lipoate protein ligase YP_002560581.1 similar to rhodanese-related sulfurtransferase YP_002560582.1 acts in conjunction with GvcH to form H-protein-S-aminomethyldihydrolipoyllysine from glycine; forms a heterodimer with subunit 1 to form the P protein YP_002560583.1 acts in conjunction with GvcH to form H-protein-S-aminomethyldihydrolipoyllysine from glycine; forms a heterodimer with subunit 2 to form the P protein YP_002560584.1 catalyzes the transfer of a methylene carbon from the methylamine-loaded GcvH protein to tetrahydrofolate, causing the release of ammonia and the generation of reduced GcvH protein YP_002560585.1 similar to shikimate kinase YP_002560586.1 similar to functionally unknown protein YP_002560587.1 similar to comG operon protein 4 YP_002560589.1 similar to DNA transport machinery protein comGB YP_002560590.1 similar to late competence protein comGA YP_002560592.1 similar to functionally unknown protein YP_002560593.1 similar to functionally unknown protein YP_002560594.1 similar to functionally unknown protein YP_002560595.1 similar to functionally unknown protein YP_002560596.1 similar to 5-formyltetrahydrofolate cyclo-ligase YP_002560598.1 ATP-binding protein; PstABCS is an ATP dependent phosphate uptake system which is responsible for inorganic phosphate uptake during phosphate starvation YP_002560604.1 similar to functionally unknown protein YP_002560605.1 catalyzes the conversion of 2C-methyl-D-erythritol 2,4-cyclodiphosphate into 4-hydroxy-3-methyl-2-en-1-yl diphosphate; involved in isoprenoid synthesis YP_002560606.1 similar to functionally unknown protein YP_002560612.1 catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP); functions in the nonmevalonate isoprenoid biosynthesis pathway YP_002560613.1 similar to functionally unknown protein YP_002560614.1 similar to functionally unknown protein YP_002560615.1 similar to cytochrome c550 YP_002560616.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; primary sigma factor of bacterium YP_002560617.1 similar to DNA primase YP_002560618.1 similar to functionally unknown protein YP_002560619.1 similar to functionally unknown protein YP_002560620.1 Catalyzes a two-step reaction, first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_002560621.1 similar to recombination protein RecO YP_002560622.1 Era; Escherichia coli Ras-like protein; Bex; Bacillus Era-complementing segment; essential protein in Escherichia coli that is involved in many cellular processes; GTPase; binds the cell membrane through apparent C-terminal domain; mutants are arrested during the cell cycle; Streptococcus pneumoniae Era binds to RNA and Escherichia coli Era binds 16S rRNA and 30S ribosome YP_002560625.1 similar to functionally unknown protein YP_002560627.1 similar to functionally unknown protein YP_002560628.1 similar to functionally unknown protein YP_002560629.1 similar to functionally unknown protein YP_002560630.1 similar to functionally unknown protein YP_002560631.1 similar to functionally unknown protein YP_002560632.1 in Escherichia coli RsmE methylates the N3 position of the U1498 base in 16S rRNA; cells lacking this function can grow, but are outcompeted by wild-type; SAM-dependent m(3)U1498 methyltransferase YP_002560633.1 methylates ribosomal protein L11 at multiple amino acid positions; mutations of these genes in Escherichia coli or Thermus thermophilus has no apparent phenotype YP_002560634.1 chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion YP_002560635.1 heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria YP_002560636.1 with DnaK and DnaJ acts in response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins; may act as a thermosensor YP_002560638.1 catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III YP_002560639.1 binds to the ribosome on the universally-conserved alpha-sarcin loop YP_002560640.1 required for the assembly and function of the DNAX complex which is required for the assembly of the beta subunit onto primed DNA YP_002560641.1 similar to DNA internalization-related competence protein ComEC/Rec2 YP_002560643.1 similar to competence protein comEA YP_002560644.1 similar to methyltransferase YP_002560645.1 similar to functionally unknown protein YP_002560646.1 similar to functionally unknown protein YP_002560647.1 similar to nicotinate-nucleotide adenylyltransferase YP_002560648.1 similar to shikimate 5-dehydrogenase YP_002560649.1 in Bacillus subtilis this enzyme appears to be involved in 30S ribosomal RNA subunit biogenesis YP_002560650.1 similar to HAD-superfamily phosphatase YP_002560652.1 necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus YP_002560653.1 functions in pyrimidine salvage; pyrimidine ribonucleoside kinase; phosphorylates nucleosides or dinucleosides to make UMP or CMP using ATP or GTP as the donor YP_002560654.1 similar to peptidase YP_002560655.1 similar to peptidase YP_002560656.1 similar to O-methyltransferase YP_002560657.1 similar to aminodeoxychorismate lyase YP_002560658.1 similar to functionally unknown protein YP_002560659.1 similar to holliday junction resolvase YP_002560660.1 similar to functionally unknown protein YP_002560661.1 Catalyzes a two-step reaction, first charging an alanyl molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_002560663.1 similar to tetratricopeptide repeat family protein YP_002560664.1 catalyzes a sulfuration reaction to synthesize 2-thiouridine at the U34 position of tRNAs YP_002560665.1 similar to functionally unknown protein YP_002560666.1 similar to bacterial luciferase family protein YP_002560667.1 similar to transcriptional regulator YP_002560668.1 similar to ATPase, AAA family YP_002560669.1 similar to molybdenum cofactor biosynthesis protein YP_002560670.1 catalyzes a two-step reaction, first charging an aspartate molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; contains discriminating and non-discriminating subtypes YP_002560671.1 catalyzes a two-step reaction, first charging a histidine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class II aminoacyl-tRNA synthetase; forms homodimers; some organisms have a paralogous gene, hisZ, that is similar to hisS and produces a protein that performs the first step in histidine biosynthesis along with HisG YP_002560675.1 catalyzes a salvage reaction resulting in the formation of AMP which is metabolically less costly than a de novo synthesis YP_002560676.1 similar to single-strand DNA-specific exonuclease YP_002560677.1 similar to amidohydrolase YP_002560678.1 similar to mandelate racemase, muconate lactonizing enzyme YP_002560679.1 part of the preprotein secretory system; forms a complex with protein YajC; SecDFyajC stimulates the proton motive force-driven protein translocation, seems to modulate the cycling of SecA by stabilizing its membrane-inserted state and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; in some organisms, such as Bacillus subtilis, SecD is fused to SecF YP_002560680.1 Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr) YP_002560681.1 Synthesizes oQ from preQ1 in a single S-adenosylmethionine-requiring step YP_002560683.1 plays an essential role in ATP-dependent branch migration of the Holliday junction YP_002560684.1 similar to amino acid-binding ACT domain protein YP_002560685.1 essential GTPase; exhibits high exchange rate for GTP/GDP; associates with 50S ribosomal subunit; involved in regulation of chromosomal replication YP_002560686.1 similar to sporulation responce regulatory protein Spo0B YP_002560687.1 similar to functionally unknown protein YP_002560689.1 similar to rod shape-determining protein MreD YP_002560690.1 in some organisms this protein is a transmembrane protein while in others it is periplasmic; involved in some organisms with other components of the MreBCD complex and with penicillin binding proteins in the periplasm or cell wall YP_002560691.1 similar to beta-hexosaminidase YP_002560692.1 similar to functionally unknown protein YP_002560693.1 similar to ribosomal-protein-alanine acetyltransferase YP_002560696.1 no similarity YP_002560698.1 similar to aspartic endopeptidase YP_002560699.1 similar to C4-dicarboxylate anaerobic carrier protein YP_002560701.1 valine--tRNA ligase; ValRS; converts valine ATP and tRNA(Val) to AMP PPi and valyl-tRNA(Val); class-I aminoacyl-tRNA synthetase type 1 subfamily; has a posttransfer editing process to hydrolyze mischarged Thr-tRNA(Val) which is done by the editing domain YP_002560702.1 similar to ammonia monooxygenase YP_002560703.1 no similarity YP_002560704.1 Converts (S)-4-amino-5-oxopentanoate to 5-aminolevulinate during the porphyrin biosynthesis pathway YP_002560705.1 catalyzes the formation of porphobilinogen from 5-aminolevulinate YP_002560706.1 similar to uroporphyrinogen III synthase YP_002560707.1 transformation of porphobilinogen to hydroxymethylbilane in porphyrin biosynthesis YP_002560708.1 similar to HemA concentration negative effector HemX YP_002560710.1 binds guanine nucleotides; in Escherichia coli depletion results in defective cell division and filamentation; in Bacillus subtilis this gene is essential YP_002560711.1 binds and unfolds substrates as part of the ClpXP protease YP_002560712.1 Tig; RopA; peptidyl-prolyl cis/trans isomerase; promotes folding of newly synthesized proteins; binds ribosomal 50S subunit; forms a homodimer YP_002560713.1 similar to functionally unknown protein YP_002560714.1 similar to functionally unknown protein YP_002560715.1 similar to transcriptional regulator YP_002560716.1 similar to functionally unknown protein YP_002560717.1 hydrolyzes non-standard nucleotides such as xanthine and inosine YP_002560718.1 converts L-glutamate to D-glutamate, a component of peptidoglycan YP_002560719.1 similar to MarR family transcriptional regulator YP_002560720.1 part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; the catalytic subunits are similar to fumarate reductase YP_002560721.1 part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol YP_002560723.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision YP_002560725.1 MutS2; MutS-II; involved in blocking ous and homeologous recombination; has ATPase activity stimulated by recombination intermediates; inhibits DNA strand exchange YP_002560727.1 similar to colicin V production protein YP_002560728.1 An endonuclease that specifically degrades the RNA strand of RNA-DNA hybrids YP_002560729.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a tetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 2 subfamily YP_002560730.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a heterotetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 1 subfamily YP_002560731.1 no similarity YP_002560733.1 similar to transcriptional regulator YP_002560735.1 similar to Na+/H+ antiporter YP_002560736.1 similar to SAM-dependent methyltransferases YP_002560737.1 similar to peptidase YP_002560738.1 similar to functionally unknown protein YP_002560739.1 similar to functionally unknown protein YP_002560740.1 no similarity YP_002560741.1 similar to uroporphyrin-III C-methyltransferase YP_002560744.1 similar to siroheme synthase YP_002560745.1 similar to transcriptional regulator NirR YP_002560746.1 binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit YP_002560748.1 IF-3 has several functions that are required and promote translation initiation including; preventing association of 70S by binding to 30S; monitoring codon-anticodon interactions by promoting disassociation of fMet-tRNA(fMet) from initiation complexes formed on leaderless mRNAs or incorrectly bound noninitiatior tRNAs and complexes with noncanonical start sites; stimulates codon-anticodon interactions at P-site; involved in moving mRNA to the P-site; and in recycling subunits YP_002560750.1 catalyzes a two-step reaction, first charging a threonine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; catalyzes the formation of threonyl-tRNA(Thr) from threonine and tRNA(Thr) YP_002560751.1 Primosomal protein that may act to load helicase DnaC during DNA replication YP_002560753.1 similar to transcriptional regulator NrdR YP_002560754.1 similar to Lipolytic enzyme, G-D-S-L YP_002560755.1 similar to functionally unknown protein YP_002560756.1 similar to functionally unknown protein YP_002560758.1 catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; involved in coenzyme A biosynthesis YP_002560761.1 similar to alkaline phosphatase synthesis sensor protein YP_002560764.1 Converts isocitrate to alpha ketoglutarate YP_002560765.1 catalyzes the formation of citrate from acetyl-CoA and oxaloacetate YP_002560768.1 catalyzes the formation of D-fructose 1,6-bisphosphate from D-fructose 6-phosphate in glycolysis YP_002560770.1 catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer of AccA2D2 subunits YP_002560771.1 similar to GntR family transcriptional regulator YP_002560773.1 similar to phosphoesterase YP_002560774.1 similar to functionally unknown protein YP_002560775.1 similar to functionally unknown protein YP_002560776.1 similar to metallo-beta-lactamase superfamily protein YP_002560778.1 similar to copper homeostasis protein YP_002560780.1 similar to universal stress protein UspA YP_002560781.1 AckA utilizes acetate and can acetylate CheY which increases signal strength during flagellar rotation; utilizes magnesium and ATP; also involved in conversion of acetate to aceyl-CoA YP_002560782.1 similar to S-adenosyl-L-methionine-dependent methyltransferase YP_002560784.1 similar to functionally unknown protein YP_002560785.1 similar to signal peptide peptidase YP_002560786.1 catalyzes the phosphorylation of NAD to NADP YP_002560787.1 similar to functionally unknown protein YP_002560788.1 similar to glycerophosphoryl diester phosphodiesterase YP_002560789.1 Required for the synthesis of the thiazole moiety YP_002560790.1 similar to aminotransferase, class V YP_002560791.1 acts to negatively regulates ftsZ ring formation by modulating the frequency and position of the ftsZ ring formation YP_002560792.1 similar to functionally unknown protein YP_002560794.1 similar to functionally unknown protein YP_002560797.1 similar to permeases of the major facilitator superfamily YP_002560798.1 similar to ABC transporter ATP-binding protein YP_002560799.1 no similarity YP_002560803.1 no similarity YP_002560804.1 catalyzes the degradation of histidine to urocanate and ammmonia YP_002560805.1 similar to 1-acyl-sn-glycerol-3-phosphate acyltransferase YP_002560806.1 similar to serine protease YP_002560807.1 similar to functionally unknown protein YP_002560808.1 similar to LemA protein YP_002560810.1 similar to penicillin-binding protein 1A YP_002560811.1 catalyzes the formation of 10-formyltetrahydrofolate from formate and tetrahydrofolate YP_002560812.1 Acs; catalyzes the conversion of acetate and CoA to acetyl-CoA YP_002560814.1 similar to acetoin utilization protein AcuB YP_002560817.1 catalyzes the formation of 3-deoxy-D-aribino-hept-2-ulosonate 7-phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate and the formation of prephenate from chorismate YP_002560818.1 similar to functionally unknown protein YP_002560819.1 similar to general stress protein YP_002560820.1 Catalyzes the formation of UDP-N-acetylmuramoyl-L-alanine from UDP-N-acetylmuramate and L-alanine in peptidoglycan synthesis YP_002560821.1 similar to DNA segregation ATPase FtsK/SpoIIIE family protein YP_002560823.1 similar to functionally unknown protein YP_002560824.1 similar to thioredoxin family protein YP_002560825.1 similar to functionally unknown protein YP_002560829.1 similar to aminopeptidase YP_002560830.1 similar to aminotransferase YP_002560831.1 tRNA (guanine-N(7)-)-methyltransferase; catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA by transferring the methyl residue from S-adenosyl-L-methionine YP_002560832.1 similar to functionally unknown protein YP_002560833.1 divalent metal ion-dependent extracellular dipeptidase; able to hydrolyze a broad range of dipeptides but no tri-, tetra-, or larger oligopeptides; differences in the amino acid specificity of the cleavage site varies between species; similar to succinyl-diaminopimelate desuccinylases YP_002560834.1 similar to functionally unknown protein YP_002560836.1 similar to polysaccharide biosynthesis protein YP_002560837.1 similar to functionally unknown protein YP_002560838.1 leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm; an editing domain hydrolyzes misformed products; in Methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase YP_002560839.1 similar to permease of the major facilitator superfamily YP_002560840.1 similar to functionally unknown protein YP_002560841.1 similar to methyltransferase YP_002560842.1 similar to repressor of toxins YP_002560843.1 similar to lysophospholipase YP_002560844.1 similar to functionally unknown protein YP_002560845.1 similar to functionally unknown protein YP_002560846.1 similar to NAD(P)H-flavin oxidoreductase YP_002560847.1 similar to N-acetyltransferase YP_002560848.1 similar to 2-haloalkanoic acid dehalogenase I YP_002560851.1 similar to nicotinamide mononucleotide transporter YP_002560852.1 similar to transcriptional regulator YP_002560853.1 similar to thiamine transporter YP_002560854.1 similar to proline dehydrogenase YP_002560857.1 similar to riboflavin synthase alpha chain YP_002560858.1 similar to riboflavin specific deaminase YP_002560859.1 catalyzing the hydrolysis of 4-imidazolone-5-propionate to N-formimidoyl-L-glutamate, the third step in the histidine degradation pathway YP_002560860.1 catalyzes the formation of 4-imidazolone-5-propanoate from urocanate during histidine metabolism YP_002560861.1 similar to LysR family transcriptional regulator YP_002560862.1 catalyzes the formation of glutamate and formamide from N-formimidoyl-L-glutamate YP_002560863.1 similar to functionally unknown protein YP_002560868.1 similar to functionally unknown protein YP_002560869.1 similar to glucosaminidase YP_002560870.1 similar to acetyltransferase, GNAT family YP_002560871.1 similar to endonuclease YP_002560872.1 similar to 2-oxo acid dehydrogenase, lipoyl-binding site protein YP_002560873.1 similar to transcriptional regulator, MerR family YP_002560874.1 glutathione-dependent formaldehyde dehydrogenase YP_002560875.1 similar to transcriptional regulator, TetR family YP_002560876.1 similar to functionally unknown protein YP_002560877.1 similar to small heat shock protein YP_002560878.1 similar to functionally unknown protein YP_002560879.1 similar to DNA mismatch endonuclease patch repair protein YP_002560881.1 similar to functionally unknown protein YP_002560883.1 no similarity YP_002560884.1 no similarity YP_002560885.1 similar to functionally unknown protein YP_002560886.1 similar to acetamidase/formamidase YP_002560889.1 catalyzes the reduction of arsenate to arsenite; also can dephosphorylate tyrosine phosphorylated proteins, aryl phosphates, and acyl phosphates YP_002560890.1 similar to transporter YP_002560891.1 similar to LamB/YcsF protein YP_002560893.1 similar to biotin carboxyl carrier protein of acetyl-CoA carboxylase YP_002560894.1 similar to allophanate hydrolase subunit 2 YP_002560895.1 similar to allophanate hydrolase subunit 1 YP_002560896.1 similar to subtilisin-like serine protease YP_002560897.1 similar to novel fructose-6-phosphate aldolase from Escherichia coli; enzyme from Methanocaldococcus janaschii shows transaldolase activity YP_002560898.1 similar to camphor resistance protein CrcB YP_002560899.1 similar to camphor resistance protein CrcB YP_002560900.1 similar to functionally unknown protein YP_002560902.1 PEP carboxykinase; PEP carboxylase; PEPCK; catalyzes the phosphorylation and decarboxylation of oxaloacetate to form phosphoenolpyruvate using ATP YP_002560903.1 similar to peptidase YP_002560904.1 similar to MutT/nudix family protein YP_002560905.1 no similarity YP_002560906.1 similar to O-succinylbenzoic acid synthetase YP_002560908.1 catalyzes the formation of 1,4-dihydroxy-2-naphthoate from O-succinylbenzoyl-CoA YP_002560909.1 similar to hydrolase YP_002560910.1 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylic acid synthase and 2-oxoglutarate decarboxylase YP_002560911.1 similar to menaquinone-specific isochorismate synthase YP_002560912.1 catalyzes the formation of dimethylmenaquinone from 1,4-dihydroxy-2-naphthoate and octaprenyl diphosphate YP_002560913.1 no similarity YP_002560914.1 similar to phage-related amidase YP_002560915.1 similar to phage holin YP_002560916.1 no similarity YP_002560917.1 similar to phage-related protein YP_002560918.1 similar to phage-related protein YP_002560919.1 similar to phage-related protein YP_002560920.1 similar to phage tail fiber protein YP_002560921.1 similar to phage-related protein YP_002560922.1 similar to phage major tail protein YP_002560923.1 similar to phage-related protein YP_002560924.1 similar to phage-related protein YP_002560925.1 similar to phage head-tail adaptor YP_002560926.1 similar to phage DNA packaging protein YP_002560927.1 similar to phage capsid protein YP_002560928.1 similar to phage prohead protease YP_002560929.1 similar to phage portal protein YP_002560930.1 similar to phage terminase large subunit YP_002560931.1 similar to phage terminase small subunit YP_002560932.1 similar to phage endonuclease YP_002560933.1 similar to phage-related protein YP_002560934.1 no similarity YP_002560935.1 similar to functionally unknown protein YP_002560936.1 similar to methylase of type III restriction-modification system YP_002560937.1 similar to phage-related protein YP_002560941.1 no similarity YP_002560942.1 no similarity YP_002560943.1 similar to primosome component and related proteins YP_002560945.1 similar to phage-related protein YP_002560946.1 similar to phage-related protein YP_002560947.1 no similarity YP_002560949.1 similar to competence transcription factor YP_002560951.1 catalyzes the formation of protoporphyrin IX from protoporphyrinogen IX YP_002560952.1 protoheme ferro-lyase; catalyzes the insertion of a ferrous ion into protoporphyrin IX to form protoheme; involved in protoheme biosynthesis; in some organisms this protein is membrane-associated while in others it is cytosolic YP_002560953.1 catalyzes the formation of coproporphyrinogen from uroporphyrinogen III YP_002560954.1 similar to signal transduction protein YP_002560955.1 similar to transporter protein YP_002560958.1 similar to functionally unknown protein YP_002560959.1 hpr; ScoC; MarR family; protease production regulatory protein YP_002560960.1 similar to functionally unknown protein YP_002560962.1 catalyzes the exonucleic cleavage of mRNA yielding nucleioside 5'-phosphates YP_002560963.1 similar to functionally unknown protein YP_002560964.1 similar to functionally unknown protein YP_002560965.1 catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III YP_002560966.1 similar to functionally unknown protein YP_002560967.1 similar to functionally unknown protein YP_002560968.1 similar to DNA-binding protein YP_002560975.1 nitrilase/cyanide hydratase and apolipoprotein N-acyltransferase YP_002560977.1 similar to nitroreductase YP_002560978.1 catalyzes the reversible transfer of the terminal phosphate of ATP to form a long chain polyphosphate YP_002560980.1 class II family (does not require metal); tetrameric enzyme; fumarase C; reversibly converts (S)-malate to fumarate and water; functions in the TCA cycle YP_002560981.1 similar to functionally unknown protein YP_002560982.1 similar to a membrane protein YP_002560985.1 similar to iron-sulfur cluster-binding protein YP_002560988.1 similar to aromatic amino acid aminotransferase YP_002560989.1 similar to functionally unknown protein YP_002560991.1 similar to permease YP_002560992.1 similar to transcriptional regulator YP_002560993.1 similar to functionally unknown protein YP_002560994.1 similar to transcription regulator Fur family protein YP_002560995.1 similar to D-isomer specific 2-hydroxyacid dehydrogenase YP_002560996.1 similar to bacterioferritin comigratory protein YP_002560997.1 converts (S)-4-amino-5-oxopentanoate to 5-aminolevulinate YP_002560998.1 similar to functionally unknown protein YP_002560999.1 similar to DNA-3-methyladenine glycosylase YP_002561000.1 similar to ABC transporter ATP-binding protein YP_002561001.1 similar to functionally unknown protein YP_002561003.1 similar to functionally unknown protein YP_002561004.1 similar to teichoic acid translocation permease YP_002561005.1 similar to teichoic acid translocation ATP-binding protein TagH YP_002561006.1 similar to functionally unknown protein YP_002561007.1 binds RecA and inhibits RecA-mediated DNA strand exchange and ATP hydrolysis and coprotease activities YP_002561008.1 monofunctional; catalyzes the elongation of glycan strands in cell wall biosynthesis YP_002561009.1 similar to ThiJ/PfpI family protein YP_002561011.1 similar to functionally unknown protein YP_002561012.1 similar to functionally unknown protein YP_002561014.1 similar to functionally unknown protein YP_002561015.1 similar to functionally unknown protein YP_002561019.1 similar to functionally unknown protein YP_002561020.1 no similarity YP_002561021.1 catalyzes the removal of N-terminal amino acids from peptides and arylamides; generally Co(II) however activity has been shown for some methionine aminopeptidases with Zn, Fe, or Mn YP_002561022.1 similar to functionally unknown protein YP_002561023.1 no similarity YP_002561024.1 similar to cell division and morphogenesis-related protein YP_002561029.1 similar to functionally unknown protein YP_002561030.1 similar to exonuclease YP_002561031.1 involved in translesion DNA polymerization with beta clamp of polymerase III; belongs to Y family of polymerases; does not contain proofreading function YP_002561034.1 similar to YegS from E. coli YP_002561036.1 similar to functionally unknown protein YP_002561037.1 similar to functionally unknown protein YP_002561038.1 similar to capsular polysaccharide biosynthesis protein EpsC YP_002561039.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA YP_002561040.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA YP_002561043.1 similar to staphylococcal sex pheromone YP_002561047.1 similar to D-alanyl-D-alanine carboxypeptidase YP_002561048.1 similar to D-alanyl-D-alanine carboxypeptidase YP_002561049.1 Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide YP_002561050.1 similar to functionally unknown protein YP_002561051.1 catalyzes the formation of nicotinamide adenine dinucleotide (NAD) from nicotinic acid adenine dinucleotide (NAAD) using either ammonia or glutamine as the amide donor and ATP; ammonia-utilizing enzymes include the ones from Bacillus and Escherichia coli while glutamine-utilizing enzymes include the Mycobacterial one; forms homodimers YP_002561052.1 catalyzes the formation of 5-phospho-alpha-D-ribose 1-diphosphate and nicotinate from nicotinate D-ribonucleotide and diphosphate YP_002561053.1 similar to transriptional regulator YP_002561054.1 similar to nitric-oxide synthase YP_002561055.1 similar to functionally unknown protein YP_002561056.1 similar to pyrazinamidase/nicotinamidase YP_002561058.1 similar to oxidoreductase YP_002561060.1 similar to methylthioribose recycling protein YP_002561061.1 similar to functionally unknown protein YP_002561062.1 no similarity YP_002561063.1 similar to functionally unknown protein YP_002561064.1 similar to lysine decarboxylase YP_002561066.1 catalyzes the formation of spermidine from putrescine and S-adenosylmethioninamine YP_002561067.1 similar to agmatinase YP_002561068.1 similar to functionally unknown protein YP_002561069.1 no similarity YP_002561070.1 no similarity YP_002561071.1 similar to functionally unknown protein YP_002561072.1 similar to MutT family protein YP_002561074.1 similar to aminopeptidase YP_002561075.1 similar to functionally unknown protein YP_002561076.1 similar to functionally unknown protein YP_002561077.1 similar to functionally unknown protein YP_002561079.1 similar to XRE family transcriptional regulator YP_002561080.1 similar to monooxygenase family protein YP_002561081.1 similar to GNAT family acetyltransferase YP_002561082.1 similar to E1-E2 family cation-transporting ATPase YP_002561083.1 cadmium-binding protein YP_002561084.1 no similarity YP_002561085.1 similar to serine/threonine phosphatase family protein YP_002561086.1 no similarity YP_002561088.1 no similarity YP_002561089.1 similar to dehydrogenase YP_002561090.1 similar to functionally unknown protein YP_002561091.1 no similarity YP_002561092.1 similar to ABC-type multidrug transporter, ATPase and permeases YP_002561093.1 no similarity YP_002561094.1 similar to functionally unknown protein YP_002561095.1 similar to functionally unknown protein YP_002561096.1 no similarity YP_002561097.1 similar to functionally unknown protein YP_002561098.1 no similarity YP_002561099.1 similar to functionally unknown protein YP_002561100.1 similar to aryldialkylphosphatase related protein YP_002561101.1 similar to sensory transduction protein kinase YP_002561102.1 similar to ABC transporter permease YP_002561103.1 similar to ABC-type multidrug transporter YP_002561104.1 similar to two-component response regulator YP_002561105.1 no similarity YP_002561106.1 similar to functionally unknown protein YP_002561107.1 similar to functionally unknown protein YP_002561109.1 similar to functionally unknown protein YP_002561110.1 similar to functionally unknown protein YP_002561111.1 similar to functionally unknown protein YP_002561113.1 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is essential for growth YP_002561114.1 10 kDa chaperonin; Cpn10; GroES; forms homoheptameric ring; binds to one or both ends of the GroEL double barrel in the presence of adenine nucleotides capping it; folding of unfolded substrates initiates in a GroEL-substrate bound and capped by GroES; release of the folded substrate is dependent on ATP binding and hydrolysis in the trans ring YP_002561115.1 similar to functionally unknown protein YP_002561116.1 similar to functionally unknown protein YP_002561119.1 no similarity YP_002561120.1 similar to glyoxalase family protein YP_002561121.1 similar to transcriptional regulator YP_002561123.1 similar to component of the twin-arginine pre-protein translocation pathway protein YP_002561124.1 modulates transcription in response to the NADH/NAD(+) redox state YP_002561126.1 similar to glycoprotease YP_002561127.1 similar to acetyltransferase YP_002561128.1 similar to glycoprotease YP_002561129.1 similar to functionally unknown protein YP_002561130.1 similar to functionally unknown protein YP_002561132.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; sigma B is not essential for sporulation; rather it is required for maximal expression of ctc and csbA which are transcribed in the early stationary phase under conditions inimical to sporulation; induced by heat shock, salt stress, oxidative stress, glucose limitation, oxygen limitation and entry into stationary phase YP_002561133.1 binds to sigma-B preventing the formation of an RNA polymerase holoenzyme YP_002561136.1 similar to functionally unknown protein YP_002561139.1 similar to functionally unknown protein YP_002561140.1 similar to functionally unknown protein YP_002561141.1 similar to functionally unknown protein YP_002561142.1 similar to ATP-dependent RNA helicase YP_002561144.1 D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli YP_002561146.1 similar to cardiolipin synthetase YP_002561147.1 similar to hydrolase, HD family YP_002561148.1 similar to functionally unknown protein YP_002561150.1 catalyzes the formation of 4-methyl-5-(2-phosphoethyl)-thiazole and ADP from 4-methyl-5-(2-hydroxyethyl)-thiazole and ATP YP_002561152.1 similar to trasncriptional activator TenA YP_002561153.1 no similarity YP_002561154.1 no similarity YP_002561156.1 similar to functionally unknown protein YP_002561157.1 in Pseudomonas aeruginosa this enzyme is a trimer of dimers; essential for membrane formation; performs third step of type II fatty acid biosynthesis; catalyzes dehydration of (3R)-hydroxyacyl-ACP to trans-2-acyl-ACP YP_002561160.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The beta chain is a regulatory subunit YP_002561162.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the alpha chain is a catalytic subunit YP_002561164.1 produces ATP from ADP in the presence of a proton gradient across the membrane; subunit B is part of the membrane proton channel YP_002561165.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit A is part of the membrane proton channel F0 YP_002561166.1 similar to ATP synthase protein I YP_002561168.1 Catalyzes the formation of uracil and 5-phospho-alpha-D-ribosy 1-diphosphate from UMP and diphosphate YP_002561170.1 similar to functionally unknown protein YP_002561172.1 similar to low molecular weight protein-tyrosine-phosphatase YP_002561173.1 similar to functionally unknown protein YP_002561174.1 similar to protoporphyrinogen oxidase YP_002561175.1 recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1; this protein is similar to release factor 2 YP_002561176.1 catalyzes the formation of thymidine 5'-phosphate from thymidine YP_002561177.1 RpmE2; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster do not have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome YP_002561178.1 An RNA-DNA helicase that actively releases nascent mRNAs from paused transcription complexes YP_002561179.1 type II fructose 1,6-bisphosphatae; in Escherichia coli this protein forms a dimer and binds manganese YP_002561180.1 similar to transcriptional regulator YP_002561181.1 adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active YP_002561182.1 catalyzes the formation of glycerone phosphate and glyceraldehyde 3-phosphate from fructose 1,6, bisphosphate; induced by anaerobic conditions in Bacillus subtilis YP_002561183.1 no similarity YP_002561184.1 similar to functionally unknown protein YP_002561185.1 CTP synthase; cytidine triphosphate synthetase; catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen; in Escherichia coli this enzyme forms a homotetramer YP_002561186.1 participates in both the initiation and recycling phases of transcription; in the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling YP_002561188.1 catalyzes the formation of (R)-4'-phosphopantothenate from (R)-pantothenate in coenzyme A biosynthesis; type II pantothenate kinases are not regulated by feedback inhibition by coenzyme A YP_002561189.1 similar to functionally unknown protein YP_002561191.1 similar to glutamate-rich protein grpB YP_002561192.1 no similarity YP_002561194.1 catalyzes the hydrolysis of S-ribosylhomocysteine to homocysteine and autoinducer-2 YP_002561195.1 no similarity YP_002561196.1 no similarity YP_002561197.1 catalyzes the transfer of phosphate between the C1 and C5 carbons of pentose YP_002561200.1 similar to transcriptional regulator YP_002561202.1 no similarity YP_002561203.1 similar to permease of the major facilitator superfamily YP_002561206.1 similar to universal stress protein UspA and related nucleotide-binding protein ue YP_002561207.1 similar to functionally unknown protein YP_002561208.1 similar to functionally unknown protein YP_002561209.1 no similarity YP_002561211.1 similar to functionally unknown protein YP_002561212.1 similar to functionally unknown protein YP_002561213.1 no similarity YP_002561214.1 similar to functionally unknown protein YP_002561215.1 similar to functionally unknown protein YP_002561216.1 no similarity YP_002561217.1 no similarity YP_002561218.1 Catalyzes the reduction of nucleoside 5'-triphosphates to 2'-deoxynucleoside 5'-triphosphates YP_002561219.1 similar to anaerobic ribonucleotide reductase activator protein YP_002561220.1 similar to functionally unknown protein YP_002561221.1 similar to hydrolase YP_002561222.1 similar to functionally unknown protein YP_002561223.1 no similarity YP_002561224.1 similar to MutT/nudix family protein YP_002561225.1 similar to iron compound ABC transporter permease YP_002561226.1 similar to iron compound ABC transporter periplasmic component YP_002561227.1 catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class-I aminoacyl-tRNA synthetase YP_002561228.1 similar to functionally unknown protein YP_002561229.1 similar to functionally unknown protein YP_002561230.1 similar to phosphohydrolase YP_002561231.1 similar to 2-keto-4-pentenoate hydratase YP_002561232.1 similar to functionally unknown protein YP_002561233.1 similar to functionally unknown protein YP_002561234.1 similar to carbamoylphosphate synthase large subunit YP_002561236.1 in Salmonella this enzyme is required for ethanolamine catabolism; has higher affinity for CoA than Pta YP_002561237.1 similar to functionally unknown protein YP_002561240.1 similar to ferrichrome ABC transporter permease YP_002561243.1 similar to amino acid transporter YP_002561244.1 similar to functionally unknown protein YP_002561245.1 similar to functionally unknown protein YP_002561246.1 Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine YP_002561248.1 similar to functionally unknown protein YP_002561249.1 similar to functionally unknown protein YP_002561250.1 similar protein in Methanocaldococcus converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate as the first step in methanopterin biosynthesis YP_002561252.1 similar to functionally unknown protein YP_002561253.1 similar to cytosine adenosine deaminase YP_002561256.1 no similarity YP_002561257.1 similar to functionally unknown protein YP_002561258.1 catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids YP_002561259.1 similar to functionally unknown protein YP_002561260.1 catalyzes the formation of 2-amino-3-oxobutanoate from acetyl-CoA and glycine YP_002561261.1 similar to functionally unknown protein YP_002561263.1 similar to amidohydrolase YP_002561264.1 EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu YP_002561265.1 EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene YP_002561266.1 binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit YP_002561267.1 interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone; located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side; mutations in the S12 gene confer streptomycin resistance YP_002561268.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Subunit beta' binds to sigma factor allowing it to bind to the -10 region of the promoter YP_002561269.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme YP_002561270.1 similar to functionally unknown protein YP_002561271.1 present in two forms; L12 is normal, while L7 is aminoacylated at the N-terminal serine; the only multicopy ribosomal protein; 4:1 ratio of L7/L12 per ribosome; two L12 dimers bind L10; critically important for translation efficiency and fidelity; stimulates GTPase activity of translation factors YP_002561272.1 BL5 YP_002561273.1 in Escherichia coli and Methanococcus, this protein autoregulates expression; the binding site in the mRNA mimics the binding site in the 23S rRNA YP_002561276.1 forms a complex with SecY and SecG; SecYEG forms a protein-conducting channel to which secA binds and translocates targeted polypeptides across the cytoplasmic membrane, a process driven by ATP and a proton-motive force YP_002561277.1 similar to RNA polymerase sigma-H factor YP_002561278.1 similar to functionally unknown protein YP_002561279.1 similar to functionally unknown protein YP_002561280.1 similar to functionally unknown protein YP_002561281.1 catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA YP_002561283.1 Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation YP_002561286.1 similar to functionally unknown protein YP_002561287.1 Sms; stabilizes the strand-invasion intermediate during the DNA repair; involved in recombination of donor DNA and plays an important role in DNA damage repair after exposure to mutagenic agents YP_002561291.1 similar to functionally unknown protein YP_002561294.1 similar to nitroreductase YP_002561295.1 with PdxST is involved in the biosynthesis of pyridoxal 5'-phosphate; PdxT catalyzes the hydrolysis of glutamine to glutamate and ammonia; PdxS utilizes the ammonia to synthesize pyridoxal 5'-phosphate YP_002561296.1 with PdxT forms pyridoxal 5'-phosphate from glutamine, either ribose 5-phosphate or ribulose 5-phosphate, and either glyceraldehyde 3-phosphate or dihydroxyacetone phosphate YP_002561297.1 similar to GntR family transcriptional regulator YP_002561298.1 class II; LysRS2; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in Methanosarcina barkeri, LysRS2 charges both tRNA molecules for lysine that exist in this organism and in addition can charge the tRNAPyl with lysine in the presence of LysRS1 YP_002561299.1 similar to ihydrouridine synthase TIM-barrel protein YP_002561304.1 similar to heat shock chaperonin protein 33 YP_002561307.1 similar to tRNA(Ile)-lysidine synthetase YP_002561308.1 similar to functionally unknown protein YP_002561309.1 similar to cell-division initiation protein YP_002561311.1 similar to polysaccharide biosynthesis protein YP_002561313.1 Enables the recycling of peptidyl-tRNAs produced at termination of translation YP_002561314.1 the Ctc family of proteins consists of two types, one that contains the N-terminal ribosomal protein L25 domain only which in Escherichia coli binds the 5S rRNA while a subset of proteins contain a C-terminal extension that is involved in the stress response YP_002561315.1 catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP YP_002561316.1 forms a homotrimer; catalyzes the acetylation of glucosamine-1-phosphate and uridylation of N-acetylglucosamine-1-phosphate to produce UDP-GlcNAc; function in cell wall synthesis YP_002561317.1 stage V sporulation protein G; essential for spore formation and a negative regulator of asymmetric septation in Bacillus; involved in methicillin-resistance, biofilm formation and capsular polysaccharide synthesis in Staphylococcus YP_002561321.1 An essential enzyme in the nonmevalonate pathway of isopentenyl diphosphate and dimethylallyl diphosphate biosynthesis YP_002561322.1 catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases A1518 and A1519 in 16S rRNA; mutations in ksgA causes resistance to the translation initiation inhibitor kasugamycin YP_002561323.1 similar to functionally unknown protein YP_002561324.1 similar to TatD family deoxyribonuclease YP_002561325.1 methionine--tRNA ligase; MetRS; adds methionine to tRNA(Met) with cleavage of ATP to AMP and diphosphate; some MetRS enzymes form dimers depending on a C-terminal domain that is also found in other proteins such as Trbp111 in Aquifex aeolicus and the cold-shock protein CsaA from Bacillus subtilis while others do not; four subfamilies exist based on sequence motifs and zinc content YP_002561328.1 similar to functionally unknown protein YP_002561329.1 in Bacillus subtilis this protein is involved in the negative regulation of DNA replication initiation; interacts with DnaN and DnaA YP_002561330.1 similar to signal peptidase YP_002561331.1 similar to DNA polymerase III delta subunit YP_002561332.1 similar to functionally unknown protein YP_002561333.1 catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to thymidine monophosphate (dTMP) to form thymidine diphosphate (dTDP) YP_002561334.1 similar to Orn/Lys/Arg decarboxylase family protein YP_002561335.1 similar to functionally unknown protein YP_002561336.1 involved in a recombinational process of DNA repair, independent of the recBC complex YP_002561337.1 similar to functionally unknown protein YP_002561342.1 similar to functionally unknown protein YP_002561343.1 no similarity YP_002561344.1 contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway YP_002561347.1 Catalyzes the transfer of the phosphoribosyl moiety from 5-phospho--D-ribosyl-1-pyrophosphate (PRib-PP) to the 6-oxo-guanine and -xanthine YP_002561348.1 similar to functionally unknown protein YP_002561349.1 no similarity YP_002561352.1 similar to functionally unknown protein YP_002561355.1 similar to chromosome partitioning protein ParB YP_002561357.1 GidA; glucose-inhibited cell division protein A; involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U) of the wobble uridine base in some tRNAs YP_002561358.1 in Escherichia coli this protein is involved in the biosynthesis of the hypermodified nucleoside 5-methylaminomethyl-2-thiouridine, which is found in the wobble position of some tRNAs and affects ribosomal frameshifting; shows potassium-dependent dimerization and GTP hydrolysis; also involved in regulation of glutamate-dependent acid resistance and activation of gadE YP_002561359.1 similar to single-stranded nucleic acid binding protein YP_002561360.1 protein component of RNaseP which catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'terminus; this enzyme also cleaves other RNA substrates YP_002561362.1 similar to functionally unknown protein YP_002561363.1 similar to mobilization protein MobA YP_002561366.1 similar to functionally unknown protein YP_002561367.1 similar to mobilization protein MobC YP_002561368.1 similar to mobilization protein MobA YP_002561371.1 no similarity YP_002561373.1 no similarity YP_002561375.1 no similarity YP_002561376.1 no similarity