-- dump date 20140619_131851 -- class Genbank::misc_feature -- table misc_feature_note -- id note 762051000001 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 762051000002 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 762051000003 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 762051000004 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 762051000005 dimerization interface [polypeptide binding]; other site 762051000006 putative DNA binding site [nucleotide binding]; other site 762051000007 putative Zn2+ binding site [ion binding]; other site 762051000008 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 762051000009 active site residue [active] 762051000010 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 762051000011 catalytic residues [active] 762051000012 SnoaL-like domain; Region: SnoaL_2; pfam12680 762051000013 multiple promoter invertase; Provisional; Region: mpi; PRK13413 762051000014 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 762051000015 catalytic residues [active] 762051000016 catalytic nucleophile [active] 762051000017 Presynaptic Site I dimer interface [polypeptide binding]; other site 762051000018 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 762051000019 Synaptic Flat tetramer interface [polypeptide binding]; other site 762051000020 Synaptic Site I dimer interface [polypeptide binding]; other site 762051000021 DNA binding site [nucleotide binding] 762051000022 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 762051000023 DNA-binding interface [nucleotide binding]; DNA binding site 762051000024 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 762051000025 HTH-like domain; Region: HTH_21; pfam13276 762051000026 Integrase core domain; Region: rve; pfam00665 762051000027 Integrase core domain; Region: rve_3; cl15866 762051000028 Transposase; Region: HTH_Tnp_1; pfam01527 762051000029 Plasmid recombination enzyme; Region: Mob_Pre; pfam01076 762051000030 Protein involved in initiation of plasmid replication [DNA replication, recombination, and repair]; Region: COG5527 762051000031 Initiator Replication protein; Region: Rep_3; pfam01051 762051000032 Lactococcus lactis RepB C-terminus; Region: L_lactis_RepB_C; pfam06430 762051000033 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_c; cd10311 762051000034 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 762051000035 putative active site [active] 762051000036 catalytic site [active] 762051000037 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 762051000038 ATP binding site [chemical binding]; other site 762051000039 putative Mg++ binding site [ion binding]; other site 762051000040 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 762051000041 nucleotide binding region [chemical binding]; other site 762051000042 ATP-binding site [chemical binding]; other site 762051000043 Domain of unknown function (DUF4391); Region: DUF4391; pfam14335 762051000044 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 762051000045 DNA methylase; Region: N6_N4_Mtase; pfam01555 762051000046 DNA methylase; Region: N6_N4_Mtase; cl17433 762051000047 Restriction endonuclease [Defense mechanisms]; Region: COG3587 762051000048 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 762051000049 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 762051000050 catalytic residues [active] 762051000051 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 762051000052 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 762051000053 catalytic residues [active] 762051000054 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 762051000055 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 762051000056 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 762051000057 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 762051000058 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 762051000059 catalytic residues [active] 762051000060 Plasmid recombination enzyme; Region: Mob_Pre; pfam01076 762051000061 Protein involved in initiation of plasmid replication [DNA replication, recombination, and repair]; Region: COG5527 762051000062 Initiator Replication protein; Region: Rep_3; pfam01051 762051000063 Lactococcus lactis RepB C-terminus; Region: L_lactis_RepB_C; pfam06430 762051000064 MarR family; Region: MarR_2; cl17246 762051000065 Type III restriction/modification enzyme methylation subunit; Region: TypeIII_RM_meth; pfam12564 762051000066 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 762051000067 DNA methylase; Region: N6_N4_Mtase; pfam01555 762051000068 DNA methylase; Region: N6_N4_Mtase; pfam01555 762051000069 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 762051000070 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3421 762051000071 ATP binding site [chemical binding]; other site 762051000072 putative Mg++ binding site [ion binding]; other site 762051000073 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 762051000074 dimerization interface [polypeptide binding]; other site 762051000075 putative DNA binding site [nucleotide binding]; other site 762051000076 putative Zn2+ binding site [ion binding]; other site 762051000077 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 762051000078 active site residue [active] 762051000079 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 762051000080 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 762051000081 catalytic residues [active] 762051000082 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 762051000083 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 762051000084 catalytic residues [active] 762051000085 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 762051000086 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 762051000087 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 762051000088 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 762051000089 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 762051000090 catalytic residues [active] 762051000091 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 762051000092 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 762051000093 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 762051000094 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 762051000095 active site 762051000096 DNA binding site [nucleotide binding] 762051000097 Int/Topo IB signature motif; other site 762051000098 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 762051000099 Cadmium resistance transporter; Region: Cad; pfam03596 762051000100 cadmium resistance transporter (or sequestration) family protein; Region: cad; TIGR00779 762051000101 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 762051000102 Integrase core domain; Region: rve; pfam00665 762051000103 Transcriptional regulators [Transcription]; Region: PurR; COG1609 762051000104 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 762051000105 DNA binding site [nucleotide binding] 762051000106 domain linker motif; other site 762051000107 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 762051000108 dimerization interface [polypeptide binding]; other site 762051000109 ligand binding site [chemical binding]; other site 762051000110 sodium binding site [ion binding]; other site 762051000111 galactoside permease; Reviewed; Region: lacY; PRK09528 762051000112 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762051000113 putative substrate translocation pore; other site 762051000114 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 762051000115 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 762051000116 substrate binding [chemical binding]; other site 762051000117 active site 762051000118 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 762051000119 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 762051000120 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 762051000121 Coenzyme A binding pocket [chemical binding]; other site 762051000122 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 762051000123 active site 762051000124 DNA binding site [nucleotide binding] 762051000125 Int/Topo IB signature motif; other site 762051000126 Transposase; Region: HTH_Tnp_1; cl17663 762051000127 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 762051000128 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 762051000129 Cl binding site [ion binding]; other site 762051000130 oligomer interface [polypeptide binding]; other site 762051000131 potential frameshift: common BLAST hit: gi|170016298|ref|YP_001727219.1| putative mobilization protein 762051000132 Plasmid recombination enzyme; Region: Mob_Pre; pfam01076 762051000133 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cl02760 762051000134 heme-binding site [chemical binding]; other site 762051000135 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 762051000136 heme-binding site [chemical binding]; other site 762051000137 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 762051000138 heme-binding site [chemical binding]; other site 762051000139 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 762051000140 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 762051000141 Walker A/P-loop; other site 762051000142 ATP binding site [chemical binding]; other site 762051000143 Q-loop/lid; other site 762051000144 ABC transporter signature motif; other site 762051000145 Walker B; other site 762051000146 D-loop; other site 762051000147 H-loop/switch region; other site 762051000148 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 762051000149 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 762051000150 active site 762051000151 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 762051000152 active site 762051000153 DNA binding site [nucleotide binding] 762051000154 Int/Topo IB signature motif; other site 762051000155 Plasmid recombination enzyme; Region: Mob_Pre; pfam01076 762051000156 Protein involved in initiation of plasmid replication [DNA replication, recombination, and repair]; Region: COG5527 762051000157 Initiator Replication protein; Region: Rep_3; pfam01051 762051000158 Lactococcus lactis RepB C-terminus; Region: L_lactis_RepB_C; pfam06430 762051000159 HTH DNA binding domain; Region: HTH_10; pfam04967 762051000160 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 762051000161 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 762051000162 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 762051000163 ATP binding site [chemical binding]; other site 762051000164 putative Mg++ binding site [ion binding]; other site 762051000165 HsdM N-terminal domain; Region: HsdM_N; pfam12161 762051000166 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 762051000167 Methyltransferase domain; Region: Methyltransf_26; pfam13659 762051000168 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 762051000169 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 762051000170 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 762051000171 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 762051000172 Low molecular weight phosphatase family; Region: LMWPc; cd00115 762051000173 active site 762051000174 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK07251 762051000175 TrkA-N domain; Region: TrkA_N; pfam02254 762051000176 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 762051000177 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 762051000178 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 762051000179 Helix-turn-helix domain; Region: HTH_38; pfam13936 762051000180 Integrase core domain; Region: rve; pfam00665 762051000181 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 762051000182 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 762051000183 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 762051000184 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 762051000185 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 762051000186 Soluble P-type ATPase [General function prediction only]; Region: COG4087 762051000187 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 762051000188 metal-binding site [ion binding] 762051000189 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 762051000190 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 762051000191 dimerization interface [polypeptide binding]; other site 762051000192 DPS ferroxidase diiron center [ion binding]; other site 762051000193 ion pore; other site 762051000194 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 762051000195 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 762051000196 ligand binding site [chemical binding]; other site 762051000197 flexible hinge region; other site 762051000198 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 762051000199 putative switch regulator; other site 762051000200 non-specific DNA interactions [nucleotide binding]; other site 762051000201 DNA binding site [nucleotide binding] 762051000202 sequence specific DNA binding site [nucleotide binding]; other site 762051000203 putative cAMP binding site [chemical binding]; other site 762051000204 CCC1-related family of proteins; Region: CCC1_like; cd01059 762051000205 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 762051000206 active site 762051000207 DNA binding site [nucleotide binding] 762051000208 Int/Topo IB signature motif; other site 762051000209 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 762051000210 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619 762051000211 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 762051000212 Walker A/P-loop; other site 762051000213 ATP binding site [chemical binding]; other site 762051000214 Q-loop/lid; other site 762051000215 ABC transporter signature motif; other site 762051000216 Walker B; other site 762051000217 D-loop; other site 762051000218 H-loop/switch region; other site 762051000219 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 762051000220 Low molecular weight phosphatase family; Region: LMWPc; cd00115 762051000221 active site 762051000222 Transposase; Region: HTH_Tnp_1; pfam01527 762051000223 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033 762051000224 putative uracil binding site [chemical binding]; other site 762051000225 putative active site [active] 762051000226 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 762051000227 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 762051000228 Integrase core domain; Region: rve; pfam00665 762051000229 Integrase core domain; Region: rve_3; cl15866 762051000230 HTH-like domain; Region: HTH_21; pfam13276 762051000231 Transposase; Region: HTH_Tnp_1; cl17663 762051000232 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 762051000233 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 762051000234 catalytic residues [active] 762051000235 catalytic nucleophile [active] 762051000236 Presynaptic Site I dimer interface [polypeptide binding]; other site 762051000237 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 762051000238 Synaptic Flat tetramer interface [polypeptide binding]; other site 762051000239 Synaptic Site I dimer interface [polypeptide binding]; other site 762051000240 DNA binding site [nucleotide binding] 762051000241 CrcB-like protein; Region: CRCB; pfam02537 762051000242 CrcB-like protein; Region: CRCB; cl09114 762051000243 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 762051000244 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 762051000245 Cl- selectivity filter; other site 762051000246 Cl- binding residues [ion binding]; other site 762051000247 pore gating glutamate residue; other site 762051000248 dimer interface [polypeptide binding]; other site 762051000249 H+/Cl- coupling transport residue; other site 762051000250 TrkA-C domain; Region: TrkA_C; pfam02080 762051000251 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 762051000252 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 762051000253 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 762051000254 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 762051000255 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 762051000256 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 762051000257 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 762051000258 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 762051000259 P-loop; other site 762051000260 Magnesium ion binding site [ion binding]; other site 762051000261 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 762051000262 Magnesium ion binding site [ion binding]; other site 762051000263 NAD-dependent DNA ligase (contains BRCT domain type II) [DNA replication, recombination, and repair]; Region: Lig; COG0272 762051000264 Plasmid recombination enzyme; Region: Mob_Pre; pfam01076 762051000265 Plasmid recombination enzyme; Region: Mob_Pre; pfam01076 762051000266 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 762051000267 Plasmid replication protein; Region: Rep_2; pfam01719 762051000268 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cd00004 762051000269 active site 762051000270 catalytic site [active] 762051000271 SH3 domain protein; Region: SH3_and_anchor; TIGR04211 762051000272 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 762051000273 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 762051000274 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 762051000275 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014 762051000276 Predicted membrane protein [Function unknown]; Region: COG2364 762051000277 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 762051000278 catalytic residues [active] 762051000279 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 762051000280 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 762051000281 Peptidase family M23; Region: Peptidase_M23; pfam01551 762051000282 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 762051000283 AAA-like domain; Region: AAA_10; pfam12846 762051000284 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 762051000285 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 762051000286 P-loop; other site 762051000287 Magnesium ion binding site [ion binding]; other site 762051000288 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 762051000289 Magnesium ion binding site [ion binding]; other site 762051000290 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 762051000291 Walker A motif; other site 762051000292 ATP binding site [chemical binding]; other site 762051000293 Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505 762051000294 TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696 762051000295 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 762051000296 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 762051000297 Walker A motif; other site 762051000298 ATP binding site [chemical binding]; other site 762051000299 Walker B motif; other site 762051000300 arginine finger; other site 762051000301 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 762051000302 Walker A motif; other site 762051000303 ATP binding site [chemical binding]; other site 762051000304 Walker B motif; other site 762051000305 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 762051000306 Protein of unknown function (DUF3991); Region: DUF3991; pfam13154 762051000307 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 762051000308 active site 762051000309 metal binding site [ion binding]; metal-binding site 762051000310 interdomain interaction site; other site 762051000311 Domain of unknown function (DUF955); Region: DUF955; cl01076 762051000312 DNA polymerase IV; Reviewed; Region: PRK03103 762051000313 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 762051000314 active site 762051000315 DNA binding site [nucleotide binding] 762051000316 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 762051000317 conserved hypothetical protein; Region: Lon_rel_chp; TIGR02653 762051000318 Putative ATP-dependent Lon protease; Region: Lon_2; pfam13337 762051000319 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 762051000320 TIGR02687 family protein; Region: TIGR02687 762051000321 PglZ domain; Region: PglZ; pfam08665 762051000322 Methyltransferase domain; Region: Methyltransf_26; pfam13659 762051000323 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 762051000324 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 762051000325 Int/Topo IB signature motif; other site 762051000326 Domain of unknown function (DUF1788); Region: DUF1788; pfam08747 762051000327 Putative inner membrane protein (DUF1819); Region: DUF1819; pfam08849 762051000328 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 762051000329 Protein of unknown function (DUF4230); Region: DUF4230; pfam14014 762051000330 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 762051000331 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 762051000332 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 762051000333 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 762051000334 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 762051000335 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 762051000336 Walker A/P-loop; other site 762051000337 ATP binding site [chemical binding]; other site 762051000338 Q-loop/lid; other site 762051000339 ABC transporter signature motif; other site 762051000340 Walker B; other site 762051000341 D-loop; other site 762051000342 H-loop/switch region; other site 762051000343 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762051000344 dimer interface [polypeptide binding]; other site 762051000345 conserved gate region; other site 762051000346 ABC-ATPase subunit interface; other site 762051000347 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 762051000348 HTH-like domain; Region: HTH_21; pfam13276 762051000349 Integrase core domain; Region: rve; pfam00665 762051000350 Transposase; Region: HTH_Tnp_1; cl17663 762051000351 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 762051000352 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_2; cd12172 762051000353 putative ligand binding site [chemical binding]; other site 762051000354 putative NAD binding site [chemical binding]; other site 762051000355 catalytic site [active] 762051000356 aspartate aminotransferase; Provisional; Region: PRK05764 762051000357 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 762051000358 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762051000359 homodimer interface [polypeptide binding]; other site 762051000360 catalytic residue [active] 762051000361 Allophanate hydrolase subunit 2; Region: AHS2; pfam02626 762051000362 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 762051000363 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 762051000364 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 762051000365 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 762051000366 putative active site [active] 762051000367 hypothetical protein; Provisional; Region: PRK05463 762051000368 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 762051000369 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 762051000370 ATP-grasp domain; Region: ATP-grasp_4; cl17255 762051000371 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 762051000372 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 762051000373 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 762051000374 carboxyltransferase (CT) interaction site; other site 762051000375 biotinylation site [posttranslational modification]; other site 762051000376 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; cl17626 762051000377 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 762051000378 dimer interface [polypeptide binding]; other site 762051000379 ssDNA binding site [nucleotide binding]; other site 762051000380 tetramer (dimer of dimers) interface [polypeptide binding]; other site 762051000381 Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970 762051000382 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 762051000383 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 762051000384 non-specific DNA binding site [nucleotide binding]; other site 762051000385 salt bridge; other site 762051000386 sequence-specific DNA binding site [nucleotide binding]; other site 762051000387 SAP domain; Region: SAP; pfam02037 762051000388 DNA polymerase IV; Reviewed; Region: PRK03103 762051000389 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 762051000390 active site 762051000391 DNA binding site [nucleotide binding] 762051000392 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 762051000393 hypothetical protein; Validated; Region: PRK06769 762051000394 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 762051000395 active site 762051000396 motif I; other site 762051000397 motif II; other site 762051000398 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 762051000399 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 762051000400 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 762051000401 Coenzyme A binding pocket [chemical binding]; other site 762051000402 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 762051000403 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 762051000404 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 762051000405 Walker A/P-loop; other site 762051000406 ATP binding site [chemical binding]; other site 762051000407 ABC transporter signature motif; other site 762051000408 Walker B; other site 762051000409 D-loop; other site 762051000410 H-loop/switch region; other site 762051000411 ABC transporter; Region: ABC_tran_2; pfam12848 762051000412 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 762051000413 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 762051000414 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762051000415 putative substrate translocation pore; other site 762051000416 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 762051000417 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 762051000418 Coenzyme A binding pocket [chemical binding]; other site 762051000419 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 762051000420 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 762051000421 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 762051000422 catalytic triad [active] 762051000423 Serine hydrolase; Region: Ser_hydrolase; cl17834 762051000424 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 762051000425 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 762051000426 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 762051000427 trimer interface [polypeptide binding]; other site 762051000428 active site 762051000429 substrate binding site [chemical binding]; other site 762051000430 CoA binding site [chemical binding]; other site 762051000431 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 762051000432 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 762051000433 putative active site [active] 762051000434 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 762051000435 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 762051000436 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 762051000437 Coenzyme A binding pocket [chemical binding]; other site 762051000438 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 762051000439 non-specific DNA binding site [nucleotide binding]; other site 762051000440 salt bridge; other site 762051000441 sequence-specific DNA binding site [nucleotide binding]; other site 762051000442 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 762051000443 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 762051000444 Coenzyme A binding pocket [chemical binding]; other site 762051000445 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 762051000446 Coenzyme A binding pocket [chemical binding]; other site 762051000447 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 762051000448 Acyl-CoA thioester hydrolase/BAAT N-terminal region; Region: Bile_Hydr_Trans; pfam04775 762051000449 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 762051000450 MarR family; Region: MarR; pfam01047 762051000451 Asp23 family; Region: Asp23; pfam03780 762051000452 Small integral membrane protein (DUF2273); Region: DUF2273; cl11575 762051000453 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 762051000454 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 762051000455 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 762051000456 classical (c) SDRs; Region: SDR_c; cd05233 762051000457 NAD(P) binding site [chemical binding]; other site 762051000458 active site 762051000459 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 762051000460 Serine hydrolase; Region: Ser_hydrolase; cl17834 762051000461 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 762051000462 Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes. All members...; Region: cytidine_deaminase-like; cl00269 762051000463 active site 762051000464 Zn binding site [ion binding]; other site 762051000465 EamA-like transporter family; Region: EamA; cl17759 762051000466 EamA-like transporter family; Region: EamA; pfam00892 762051000467 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 762051000468 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 762051000469 maltose O-acetyltransferase; Provisional; Region: PRK10092 762051000470 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 762051000471 active site 762051000472 substrate binding site [chemical binding]; other site 762051000473 trimer interface [polypeptide binding]; other site 762051000474 CoA binding site [chemical binding]; other site 762051000475 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 762051000476 dimer interface [polypeptide binding]; other site 762051000477 FMN binding site [chemical binding]; other site 762051000478 Predicted transcriptional regulators [Transcription]; Region: COG1733 762051000479 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 762051000480 Protein of unknown function (DUF419); Region: DUF419; cl15265 762051000481 pyruvate oxidase; Region: pyruv_oxi_spxB; TIGR02720 762051000482 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 762051000483 PYR/PP interface [polypeptide binding]; other site 762051000484 dimer interface [polypeptide binding]; other site 762051000485 tetramer interface [polypeptide binding]; other site 762051000486 TPP binding site [chemical binding]; other site 762051000487 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 762051000488 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 762051000489 TPP-binding site [chemical binding]; other site 762051000490 LrgB-like family; Region: LrgB; cl00596 762051000491 LrgA family; Region: LrgA; cl00608 762051000492 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 762051000493 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 762051000494 2-deoxy-D-gluconate 3-dehydrogenase; Provisional; Region: PRK06935 762051000495 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 762051000496 NADP binding site [chemical binding]; other site 762051000497 homodimer interface [polypeptide binding]; other site 762051000498 active site 762051000499 Transcriptional regulators [Transcription]; Region: PurR; COG1609 762051000500 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 762051000501 DNA binding site [nucleotide binding] 762051000502 domain linker motif; other site 762051000503 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 762051000504 Putative transcription activator [Transcription]; Region: TenA; COG0819 762051000505 acetylornithine deacetylase; Validated; Region: PRK08596 762051000506 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 762051000507 metal binding site [ion binding]; metal-binding site 762051000508 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 762051000509 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 762051000510 Ligand binding site; other site 762051000511 metal-binding site 762051000512 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 762051000513 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 762051000514 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 762051000515 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 762051000516 short chain dehydrogenase; Provisional; Region: PRK06180 762051000517 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 762051000518 NADP binding site [chemical binding]; other site 762051000519 active site 762051000520 steroid binding site; other site 762051000521 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 762051000522 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 762051000523 DNA binding residues [nucleotide binding] 762051000524 putative dimer interface [polypeptide binding]; other site 762051000525 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 762051000526 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 762051000527 dimer interface [polypeptide binding]; other site 762051000528 active site 762051000529 metal binding site [ion binding]; metal-binding site 762051000530 Predicted flavoprotein [General function prediction only]; Region: COG0431 762051000531 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 762051000532 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 762051000533 active site 762051000534 catalytic residues [active] 762051000535 beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525 762051000536 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 762051000537 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 762051000538 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 762051000539 Beta galactosidase small chain; Region: Bgal_small_N; smart01038 762051000540 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 762051000541 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 762051000542 galactokinase; Provisional; Region: PRK05322 762051000543 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 762051000544 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 762051000545 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 762051000546 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 762051000547 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 762051000548 Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744 762051000549 Transcriptional regulators [Transcription]; Region: PurR; COG1609 762051000550 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 762051000551 DNA binding site [nucleotide binding] 762051000552 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 762051000553 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588 762051000554 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 762051000555 metal binding site [ion binding]; metal-binding site 762051000556 dimer interface [polypeptide binding]; other site 762051000557 Protein of unknown function (DUF1349); Region: DUF1349; pfam07081 762051000558 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 762051000559 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 762051000560 Ca binding site [ion binding]; other site 762051000561 active site 762051000562 catalytic site [active] 762051000563 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 762051000564 active site 762051000565 active pocket/dimerization site; other site 762051000566 phosphorylation site [posttranslational modification] 762051000567 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 762051000568 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 762051000569 PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830 762051000570 active site 762051000571 phosphorylation site [posttranslational modification] 762051000572 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 762051000573 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 762051000574 putative active site [active] 762051000575 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 762051000576 H+ Antiporter protein; Region: 2A0121; TIGR00900 762051000577 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 762051000578 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 762051000579 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 762051000580 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 762051000581 Walker A/P-loop; other site 762051000582 ATP binding site [chemical binding]; other site 762051000583 Q-loop/lid; other site 762051000584 ABC transporter signature motif; other site 762051000585 Walker B; other site 762051000586 D-loop; other site 762051000587 H-loop/switch region; other site 762051000588 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 762051000589 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 762051000590 FtsX-like permease family; Region: FtsX; pfam02687 762051000591 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 762051000592 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 762051000593 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 762051000594 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 762051000595 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762051000596 acetoin reductases; Region: 23BDH; TIGR02415 762051000597 NAD(P) binding site [chemical binding]; other site 762051000598 active site 762051000599 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 762051000600 DNA photolyase; Region: DNA_photolyase; pfam00875 762051000601 oxidoreductase; Provisional; Region: PRK07985 762051000602 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762051000603 NAD(P) binding site [chemical binding]; other site 762051000604 active site 762051000605 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 762051000606 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 762051000607 potential frameshift: common BLAST hit: gi|116617911|ref|YP_818282.1| sugar phosphate isomerase 762051000608 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 762051000609 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 762051000610 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 762051000611 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 762051000612 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 762051000613 active site 762051000614 catalytic tetrad [active] 762051000615 Predicted membrane protein [Function unknown]; Region: COG2261 762051000616 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 762051000617 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 762051000618 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 762051000619 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 762051000620 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 762051000621 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 762051000622 motif II; other site 762051000623 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 762051000624 MepB protein; Region: MepB; pfam08877 762051000625 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 762051000626 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 762051000627 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 762051000628 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 762051000629 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 762051000630 S-adenosylmethionine binding site [chemical binding]; other site 762051000631 Domain of unknown function DUF77; Region: DUF77; pfam01910 762051000632 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 762051000633 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 762051000634 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 762051000635 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 762051000636 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 762051000637 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 762051000638 ligand binding site [chemical binding]; other site 762051000639 flexible hinge region; other site 762051000640 helix_turn_helix, cAMP Regulatory protein; Region: HTH_CRP; smart00419 762051000641 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 762051000642 RNA/DNA hybrid binding site [nucleotide binding]; other site 762051000643 active site 762051000644 ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596 762051000645 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 762051000646 GTP/Mg2+ binding site [chemical binding]; other site 762051000647 G4 box; other site 762051000648 G5 box; other site 762051000649 G1 box; other site 762051000650 Switch I region; other site 762051000651 G2 box; other site 762051000652 G3 box; other site 762051000653 Switch II region; other site 762051000654 hypothetical protein; Provisional; Region: PRK13672 762051000655 Uncharacterized protein conserved in bacteria (DUF2140); Region: DUF2140; pfam09911 762051000656 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 762051000657 active site 762051000658 catalytic triad [active] 762051000659 oxyanion hole [active] 762051000660 peptidase T; Region: peptidase-T; TIGR01882 762051000661 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 762051000662 metal binding site [ion binding]; metal-binding site 762051000663 dimer interface [polypeptide binding]; other site 762051000664 Uncharacterized conserved protein [Function unknown]; Region: COG0327 762051000665 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 762051000666 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 762051000667 Family of unknown function (DUF633); Region: DUF633; pfam04816 762051000668 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 762051000669 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 762051000670 metal binding site [ion binding]; metal-binding site 762051000671 substrate binding pocket [chemical binding]; other site 762051000672 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 762051000673 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 762051000674 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 762051000675 dimer interface [polypeptide binding]; other site 762051000676 tetramer interface [polypeptide binding]; other site 762051000677 PYR/PP interface [polypeptide binding]; other site 762051000678 TPP binding site [chemical binding]; other site 762051000679 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 762051000680 TPP-binding site; other site 762051000681 anthranilate synthase component I; Reviewed; Region: PRK06404 762051000682 chorismate binding enzyme; Region: Chorismate_bind; cl10555 762051000683 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; pfam07155 762051000684 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 762051000685 dimer interface [polypeptide binding]; other site 762051000686 substrate binding site [chemical binding]; other site 762051000687 ATP binding site [chemical binding]; other site 762051000688 Uncharacterized conserved protein [Function unknown]; Region: COG1284 762051000689 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 762051000690 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 762051000691 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 762051000692 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 762051000693 Coenzyme A binding pocket [chemical binding]; other site 762051000694 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 762051000695 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 762051000696 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 762051000697 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 762051000698 RNA binding site [nucleotide binding]; other site 762051000699 dihydropteroate synthase; Region: DHPS; TIGR01496 762051000700 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 762051000701 substrate binding pocket [chemical binding]; other site 762051000702 dimer interface [polypeptide binding]; other site 762051000703 inhibitor binding site; inhibition site 762051000704 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 762051000705 active site 762051000706 dimerization interface [polypeptide binding]; other site 762051000707 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 762051000708 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 762051000709 GTP cyclohydrolase I; Provisional; Region: PLN03044 762051000710 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 762051000711 active site 762051000712 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 762051000713 catalytic center binding site [active] 762051000714 ATP binding site [chemical binding]; other site 762051000715 Dihydroneopterin aldolase [Coenzyme metabolism]; Region: FolB; COG1539 762051000716 active site 762051000717 Nicotinamide mononucleotide transporter; Region: NMN_transporter; cl01256 762051000718 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 762051000719 Glutamine amidotransferase class-I; Region: GATase; pfam00117 762051000720 glutamine binding [chemical binding]; other site 762051000721 catalytic triad [active] 762051000722 anthranilate synthase component I; Provisional; Region: PRK13570 762051000723 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 762051000724 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 762051000725 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 762051000726 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 762051000727 substrate binding site [chemical binding]; other site 762051000728 active site 762051000729 catalytic residues [active] 762051000730 heterodimer interface [polypeptide binding]; other site 762051000731 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 762051000732 active site 762051000733 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 762051000734 active site 762051000735 ribulose/triose binding site [chemical binding]; other site 762051000736 phosphate binding site [ion binding]; other site 762051000737 substrate (anthranilate) binding pocket [chemical binding]; other site 762051000738 product (indole) binding pocket [chemical binding]; other site 762051000739 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 762051000740 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 762051000741 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 762051000742 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 762051000743 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 762051000744 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762051000745 catalytic residue [active] 762051000746 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 762051000747 active site 762051000748 catalytic residues [active] 762051000749 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 762051000750 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 762051000751 active site 762051000752 DNA binding site [nucleotide binding] 762051000753 Int/Topo IB signature motif; other site 762051000754 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 762051000755 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 762051000756 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 762051000757 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 762051000758 dimer interface [polypeptide binding]; other site 762051000759 active site 762051000760 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 762051000761 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 762051000762 Walker A/P-loop; other site 762051000763 ATP binding site [chemical binding]; other site 762051000764 Q-loop/lid; other site 762051000765 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 762051000766 ABC transporter signature motif; other site 762051000767 Walker B; other site 762051000768 D-loop; other site 762051000769 ABC transporter; Region: ABC_tran_2; pfam12848 762051000770 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 762051000771 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 762051000772 RNA methyltransferase, RsmE family; Region: TIGR00046 762051000773 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 762051000774 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 762051000775 S-adenosylmethionine binding site [chemical binding]; other site 762051000776 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 762051000777 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 762051000778 putative NAD(P) binding site [chemical binding]; other site 762051000779 dimer interface [polypeptide binding]; other site 762051000780 GTP-binding protein LepA; Provisional; Region: PRK05433 762051000781 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 762051000782 G1 box; other site 762051000783 putative GEF interaction site [polypeptide binding]; other site 762051000784 GTP/Mg2+ binding site [chemical binding]; other site 762051000785 Switch I region; other site 762051000786 G2 box; other site 762051000787 G3 box; other site 762051000788 Switch II region; other site 762051000789 G4 box; other site 762051000790 G5 box; other site 762051000791 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 762051000792 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 762051000793 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 762051000794 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 762051000795 glycyl-tRNA synthetase subunit alpha; Validated; Region: glyQ; PRK09348 762051000796 motif 1; other site 762051000797 dimer interface [polypeptide binding]; other site 762051000798 active site 762051000799 motif 2; other site 762051000800 motif 3; other site 762051000801 Protein of unknown function (DUF805); Region: DUF805; pfam05656 762051000802 ribosome recycling factor; Reviewed; Region: frr; PRK00083 762051000803 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 762051000804 hinge region; other site 762051000805 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 762051000806 putative nucleotide binding site [chemical binding]; other site 762051000807 uridine monophosphate binding site [chemical binding]; other site 762051000808 homohexameric interface [polypeptide binding]; other site 762051000809 elongation factor Ts; Provisional; Region: tsf; PRK09377 762051000810 UBA/TS-N domain; Region: UBA; pfam00627 762051000811 Elongation factor TS; Region: EF_TS; pfam00889 762051000812 Elongation factor TS; Region: EF_TS; pfam00889 762051000813 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 762051000814 rRNA interaction site [nucleotide binding]; other site 762051000815 S8 interaction site; other site 762051000816 putative laminin-1 binding site; other site 762051000817 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 762051000818 GIY-YIG motif/motif A; other site 762051000819 putative active site [active] 762051000820 putative metal binding site [ion binding]; other site 762051000821 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 762051000822 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 762051000823 S-adenosylmethionine binding site [chemical binding]; other site 762051000824 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 762051000825 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 762051000826 putative acyl-acceptor binding pocket; other site 762051000827 LexA repressor; Validated; Region: PRK00215 762051000828 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 762051000829 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 762051000830 Catalytic site [active] 762051000831 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 762051000832 active site 762051000833 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 762051000834 active site 762051000835 dimer interface [polypeptide binding]; other site 762051000836 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 762051000837 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 762051000838 heterodimer interface [polypeptide binding]; other site 762051000839 active site 762051000840 FMN binding site [chemical binding]; other site 762051000841 homodimer interface [polypeptide binding]; other site 762051000842 substrate binding site [chemical binding]; other site 762051000843 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 762051000844 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 762051000845 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 762051000846 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 762051000847 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 762051000848 ATP-grasp domain; Region: ATP-grasp_4; cl17255 762051000849 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 762051000850 IMP binding site; other site 762051000851 dimer interface [polypeptide binding]; other site 762051000852 interdomain contacts; other site 762051000853 partial ornithine binding site; other site 762051000854 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 762051000855 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 762051000856 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 762051000857 catalytic site [active] 762051000858 subunit interface [polypeptide binding]; other site 762051000859 dihydroorotase; Validated; Region: pyrC; PRK09357 762051000860 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 762051000861 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 762051000862 active site 762051000863 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 762051000864 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 762051000865 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 762051000866 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 762051000867 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 762051000868 Catalytic site [active] 762051000869 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 762051000870 Protein of unknown function (DUF964); Region: DUF964; cl01483 762051000871 Transglycosylase; Region: Transgly; pfam00912 762051000872 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 762051000873 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 762051000874 Arginine repressor [Transcription]; Region: ArgR; COG1438 762051000875 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 762051000876 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 762051000877 arginyl-tRNA synthetase; Reviewed; Region: PRK12451 762051000878 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 762051000879 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 762051000880 active site 762051000881 HIGH motif; other site 762051000882 KMSK motif region; other site 762051000883 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 762051000884 tRNA binding surface [nucleotide binding]; other site 762051000885 anticodon binding site; other site 762051000886 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 762051000887 Flavoprotein; Region: Flavoprotein; pfam02441 762051000888 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 762051000889 Tubby C 2; Region: Tub_2; cl02043 762051000890 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 762051000891 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 762051000892 HicB family; Region: HicB; pfam05534 762051000893 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 762051000894 UDP-N-acetylmuramoylalanyl-D-glutamate--L-lysine ligase; Provisional; Region: PRK14022 762051000895 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 762051000896 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 762051000897 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 762051000898 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 762051000899 active site 762051000900 Zn binding site [ion binding]; other site 762051000901 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 762051000902 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 762051000903 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 762051000904 Uncharacterized conserved protein [Function unknown]; Region: COG1284 762051000905 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 762051000906 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 762051000907 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 762051000908 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 762051000909 dimer interface [polypeptide binding]; other site 762051000910 anticodon binding site; other site 762051000911 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 762051000912 motif 1; other site 762051000913 dimer interface [polypeptide binding]; other site 762051000914 active site 762051000915 motif 2; other site 762051000916 GAD domain; Region: GAD; pfam02938 762051000917 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 762051000918 active site 762051000919 motif 3; other site 762051000920 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 762051000921 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 762051000922 dimer interface [polypeptide binding]; other site 762051000923 motif 1; other site 762051000924 active site 762051000925 motif 2; other site 762051000926 motif 3; other site 762051000927 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 762051000928 anticodon binding site; other site 762051000929 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 762051000930 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 762051000931 Ca binding site [ion binding]; other site 762051000932 active site 762051000933 catalytic site [active] 762051000934 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 762051000935 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762051000936 Major Facilitator Superfamily; Region: MFS_1; pfam07690 762051000937 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 762051000938 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 762051000939 Ca binding site [ion binding]; other site 762051000940 active site 762051000941 catalytic site [active] 762051000942 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 762051000943 Transcriptional regulators [Transcription]; Region: PurR; COG1609 762051000944 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 762051000945 DNA binding site [nucleotide binding] 762051000946 domain linker motif; other site 762051000947 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 762051000948 dimerization interface [polypeptide binding]; other site 762051000949 ligand binding site [chemical binding]; other site 762051000950 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 762051000951 dimer interface [polypeptide binding]; other site 762051000952 FMN binding site [chemical binding]; other site 762051000953 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 762051000954 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 762051000955 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 762051000956 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 762051000957 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 762051000958 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 762051000959 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 762051000960 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 762051000961 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 762051000962 putative dimer interface [polypeptide binding]; other site 762051000963 putative anticodon binding site; other site 762051000964 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 762051000965 homodimer interface [polypeptide binding]; other site 762051000966 motif 1; other site 762051000967 motif 2; other site 762051000968 active site 762051000969 motif 3; other site 762051000970 aspartate aminotransferase; Provisional; Region: PRK05764 762051000971 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 762051000972 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762051000973 homodimer interface [polypeptide binding]; other site 762051000974 catalytic residue [active] 762051000975 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 762051000976 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 762051000977 active site 762051000978 catalytic site [active] 762051000979 substrate binding site [chemical binding]; other site 762051000980 mevalonate kinase; Region: mevalon_kin; TIGR00549 762051000981 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 762051000982 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cd00004 762051000983 active site 762051000984 catalytic site [active] 762051000985 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 762051000986 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 762051000987 active site 762051000988 catalytic tetrad [active] 762051000989 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 762051000990 active site 762051000991 catalytic triad [active] 762051000992 oxyanion hole [active] 762051000993 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 762051000994 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 762051000995 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 762051000996 active site 762051000997 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 762051000998 AAA domain; Region: AAA_30; pfam13604 762051000999 Family description; Region: UvrD_C_2; pfam13538 762051001000 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 762051001001 catalytic core [active] 762051001002 Putative amino acid metabolism; Region: DUF1831; pfam08866 762051001003 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 762051001004 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 762051001005 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 762051001006 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 762051001007 S-adenosylmethionine binding site [chemical binding]; other site 762051001008 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 762051001009 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 762051001010 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 762051001011 substrate binding site [chemical binding]; other site 762051001012 dimer interface [polypeptide binding]; other site 762051001013 ATP binding site [chemical binding]; other site 762051001014 phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833 762051001015 DNA polymerase III PolC; Validated; Region: polC; PRK00448 762051001016 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 762051001017 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 762051001018 generic binding surface II; other site 762051001019 generic binding surface I; other site 762051001020 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 762051001021 active site 762051001022 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 762051001023 active site 762051001024 catalytic site [active] 762051001025 substrate binding site [chemical binding]; other site 762051001026 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 762051001027 prolyl-tRNA synthetase; Provisional; Region: PRK09194 762051001028 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 762051001029 dimer interface [polypeptide binding]; other site 762051001030 motif 1; other site 762051001031 active site 762051001032 motif 2; other site 762051001033 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 762051001034 putative deacylase active site [active] 762051001035 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 762051001036 active site 762051001037 motif 3; other site 762051001038 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 762051001039 anticodon binding site; other site 762051001040 RIP metalloprotease RseP; Region: TIGR00054 762051001041 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 762051001042 active site 762051001043 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 762051001044 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 762051001045 protein binding site [polypeptide binding]; other site 762051001046 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 762051001047 putative substrate binding region [chemical binding]; other site 762051001048 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 762051001049 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 762051001050 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 762051001051 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14830 762051001052 catalytic residue [active] 762051001053 putative FPP diphosphate binding site; other site 762051001054 putative FPP binding hydrophobic cleft; other site 762051001055 dimer interface [polypeptide binding]; other site 762051001056 putative IPP diphosphate binding site; other site 762051001057 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 762051001058 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 762051001059 glutaminase active site [active] 762051001060 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 762051001061 dimer interface [polypeptide binding]; other site 762051001062 active site 762051001063 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 762051001064 dimer interface [polypeptide binding]; other site 762051001065 active site 762051001066 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 762051001067 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 762051001068 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 762051001069 active site 762051001070 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 762051001071 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762051001072 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 762051001073 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 762051001074 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 762051001075 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 762051001076 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 762051001077 Domain of unknown function DUF20; Region: UPF0118; pfam01594 762051001078 diphosphomevalonate decarboxylase; Region: PLN02407 762051001079 diphosphomevalonate decarboxylase; Region: mevDPdecarb; TIGR01240 762051001080 phosphomevalonate kinase, ERG8-type, Gram-positive branch; Region: Pmev_kin_Gr_pos; TIGR01220 762051001081 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 762051001082 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 762051001083 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 762051001084 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 762051001085 homotetramer interface [polypeptide binding]; other site 762051001086 FMN binding site [chemical binding]; other site 762051001087 homodimer contacts [polypeptide binding]; other site 762051001088 putative active site [active] 762051001089 putative substrate binding site [chemical binding]; other site 762051001090 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 762051001091 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 762051001092 active site 762051001093 adenylosuccinate lyase; Provisional; Region: PRK07492 762051001094 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 762051001095 tetramer interface [polypeptide binding]; other site 762051001096 active site 762051001097 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 762051001098 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762051001099 putative substrate translocation pore; other site 762051001100 S-formylglutathione hydrolase; Region: PLN02442 762051001101 Predicted esterase [General function prediction only]; Region: COG0627 762051001102 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 762051001103 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 762051001104 Potassium binding sites [ion binding]; other site 762051001105 Cesium cation binding sites [ion binding]; other site 762051001106 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 762051001107 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 762051001108 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 762051001109 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 762051001110 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 762051001111 putative active site [active] 762051001112 nucleotide binding site [chemical binding]; other site 762051001113 nudix motif; other site 762051001114 putative metal binding site [ion binding]; other site 762051001115 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 762051001116 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 762051001117 purine monophosphate binding site [chemical binding]; other site 762051001118 dimer interface [polypeptide binding]; other site 762051001119 putative catalytic residues [active] 762051001120 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 762051001121 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 762051001122 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 762051001123 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 762051001124 active site 762051001125 substrate binding site [chemical binding]; other site 762051001126 cosubstrate binding site; other site 762051001127 catalytic site [active] 762051001128 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 762051001129 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 762051001130 dimerization interface [polypeptide binding]; other site 762051001131 putative ATP binding site [chemical binding]; other site 762051001132 amidophosphoribosyltransferase; Provisional; Region: PRK07272 762051001133 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 762051001134 active site 762051001135 tetramer interface [polypeptide binding]; other site 762051001136 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 762051001137 active site 762051001138 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 762051001139 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 762051001140 dimerization interface [polypeptide binding]; other site 762051001141 ATP binding site [chemical binding]; other site 762051001142 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 762051001143 dimerization interface [polypeptide binding]; other site 762051001144 ATP binding site [chemical binding]; other site 762051001145 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 762051001146 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 762051001147 putative active site [active] 762051001148 catalytic triad [active] 762051001149 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700 762051001150 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 762051001151 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 762051001152 ATP binding site [chemical binding]; other site 762051001153 active site 762051001154 substrate binding site [chemical binding]; other site 762051001155 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 762051001156 ATP-grasp domain; Region: ATP-grasp; pfam02222 762051001157 AIR carboxylase; Region: AIRC; pfam00731 762051001158 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 762051001159 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 762051001160 substrate binding pocket [chemical binding]; other site 762051001161 membrane-bound complex binding site; other site 762051001162 hinge residues; other site 762051001163 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762051001164 dimer interface [polypeptide binding]; other site 762051001165 conserved gate region; other site 762051001166 ABC-ATPase subunit interface; other site 762051001167 cell division protein GpsB; Provisional; Region: PRK14127 762051001168 DivIVA domain; Region: DivI1A_domain; TIGR03544 762051001169 hypothetical protein; Provisional; Region: PRK13660 762051001170 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 762051001171 Transglycosylase; Region: Transgly; pfam00912 762051001172 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 762051001173 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 762051001174 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 762051001175 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 762051001176 non-specific DNA binding site [nucleotide binding]; other site 762051001177 salt bridge; other site 762051001178 sequence-specific DNA binding site [nucleotide binding]; other site 762051001179 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 762051001180 Cpl-1 lysin (also known as Cpl-9 lysozyme / muramidase) is a bacterial cell wall endolysin encoded by the pneumococcal bacteriophage Cp-1, which cleaves the glycosidic N-acetylmuramoyl-(beta1,4)-N-acetylglucosamine bonds of the pneumococcal glycan chain; Region: GH25_Cpl1-like; cd06415 762051001181 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 762051001182 active site 762051001183 Protein of unknown function (DUF972); Region: DUF972; pfam06156 762051001184 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 762051001185 active site 762051001186 oxyanion hole [active] 762051001187 catalytic triad [active] 762051001188 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 762051001189 Phage tail protein; Region: Sipho_tail; pfam05709 762051001190 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 762051001191 flagellar assembly protein H; Validated; Region: fliH; PRK06669 762051001192 NlpC/P60 family; Region: NLPC_P60; pfam00877 762051001193 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 762051001194 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 762051001195 N-acetyl-D-glucosamine binding site [chemical binding]; other site 762051001196 catalytic residue [active] 762051001197 Phage major tail protein; Region: Phage_tail; pfam04630 762051001198 Protein of unknown function (DUF806); Region: DUF806; pfam05657 762051001199 Bacteriophage protein of unknown function (DUF646); Region: DUF646; pfam04883 762051001200 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 762051001201 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 762051001202 oligomerization interface [polypeptide binding]; other site 762051001203 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 762051001204 Phage capsid family; Region: Phage_capsid; pfam05065 762051001205 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 762051001206 oligomer interface [polypeptide binding]; other site 762051001207 active site residues [active] 762051001208 Phage portal protein; Region: Phage_portal; pfam04860 762051001209 Phage-related protein [Function unknown]; Region: COG4695; cl01923 762051001210 Phage Terminase; Region: Terminase_1; pfam03354 762051001211 Phage terminase, small subunit; Region: Terminase_4; pfam05119 762051001212 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 762051001213 active site 762051001214 Protein of unknown function (DUF722); Region: DUF722; pfam05263 762051001215 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 762051001216 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 762051001217 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 762051001218 active site 762051001219 DNA binding site [nucleotide binding] 762051001220 Int/Topo IB signature motif; other site 762051001221 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 762051001222 Endodeoxyribonuclease RusA; Region: RusA; pfam05866 762051001223 Protein of unknown function (DUF968); Region: DUF968; pfam06147 762051001224 ERF superfamily; Region: ERF; pfam04404 762051001225 Protein of unknown function (DUF1351); Region: DUF1351; pfam07083 762051001226 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 762051001227 Walker A motif; other site 762051001228 ATP binding site [chemical binding]; other site 762051001229 Walker B motif; other site 762051001230 arginine finger; other site 762051001231 Conserved phage C-terminus (Phg_2220_C); Region: Phg_2220_C; pfam09524 762051001232 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 762051001233 non-specific DNA binding site [nucleotide binding]; other site 762051001234 salt bridge; other site 762051001235 sequence-specific DNA binding site [nucleotide binding]; other site 762051001236 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; cl17818 762051001237 AntA/AntB antirepressor; Region: AntA; pfam08346 762051001238 Phage antirepressor protein KilAC domain; Region: ANT; pfam03374 762051001239 Protein of unknown function (DUF739); Region: DUF739; pfam05339 762051001240 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 762051001241 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 762051001242 non-specific DNA binding site [nucleotide binding]; other site 762051001243 salt bridge; other site 762051001244 sequence-specific DNA binding site [nucleotide binding]; other site 762051001245 Predicted transcriptional regulator [Transcription]; Region: COG2932 762051001246 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 762051001247 Catalytic site [active] 762051001248 integrase; Provisional; Region: int; PHA02601 762051001249 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 762051001250 Int/Topo IB signature motif; other site 762051001251 GMP synthase; Reviewed; Region: guaA; PRK00074 762051001252 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 762051001253 AMP/PPi binding site [chemical binding]; other site 762051001254 candidate oxyanion hole; other site 762051001255 catalytic triad [active] 762051001256 potential glutamine specificity residues [chemical binding]; other site 762051001257 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 762051001258 ATP Binding subdomain [chemical binding]; other site 762051001259 Dimerization subdomain; other site 762051001260 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK06843 762051001261 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 762051001262 phosphate binding site [ion binding]; other site 762051001263 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK06843 762051001264 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 762051001265 active site 762051001266 heat shock protein HtpX; Provisional; Region: PRK04897 762051001267 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 762051001268 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 762051001269 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 762051001270 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 762051001271 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 762051001272 HIGH motif; other site 762051001273 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 762051001274 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 762051001275 active site 762051001276 KMSKS motif; other site 762051001277 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 762051001278 tRNA binding surface [nucleotide binding]; other site 762051001279 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 762051001280 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 762051001281 active site 762051001282 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 762051001283 active site 762051001284 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 762051001285 Ligand Binding Site [chemical binding]; other site 762051001286 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 762051001287 tetramer (dimer of dimers) interface [polypeptide binding]; other site 762051001288 active site 762051001289 dimer interface [polypeptide binding]; other site 762051001290 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 762051001291 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 762051001292 Walker A/P-loop; other site 762051001293 ATP binding site [chemical binding]; other site 762051001294 Q-loop/lid; other site 762051001295 ABC transporter signature motif; other site 762051001296 Walker B; other site 762051001297 D-loop; other site 762051001298 H-loop/switch region; other site 762051001299 elongation factor Tu; Reviewed; Region: PRK00049 762051001300 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 762051001301 G1 box; other site 762051001302 GEF interaction site [polypeptide binding]; other site 762051001303 GTP/Mg2+ binding site [chemical binding]; other site 762051001304 Switch I region; other site 762051001305 G2 box; other site 762051001306 G3 box; other site 762051001307 Switch II region; other site 762051001308 G4 box; other site 762051001309 G5 box; other site 762051001310 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 762051001311 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 762051001312 Antibiotic Binding Site [chemical binding]; other site 762051001313 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 762051001314 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 762051001315 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 762051001316 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 762051001317 23S rRNA binding site [nucleotide binding]; other site 762051001318 L21 binding site [polypeptide binding]; other site 762051001319 L13 binding site [polypeptide binding]; other site 762051001320 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 762051001321 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 762051001322 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 762051001323 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 762051001324 Protein of unknown function (DUF1361); Region: DUF1361; pfam07099 762051001325 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 762051001326 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 762051001327 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 762051001328 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 762051001329 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 762051001330 active site 762051001331 dimer interface [polypeptide binding]; other site 762051001332 motif 1; other site 762051001333 motif 2; other site 762051001334 motif 3; other site 762051001335 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 762051001336 anticodon binding site; other site 762051001337 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 762051001338 amphipathic channel; other site 762051001339 Asn-Pro-Ala signature motifs; other site 762051001340 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 762051001341 hypothetical protein; Validated; Region: PRK00110 762051001342 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 762051001343 tetramer interfaces [polypeptide binding]; other site 762051001344 binuclear metal-binding site [ion binding]; other site 762051001345 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_3; cd12174 762051001346 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 762051001347 putative ligand binding site [chemical binding]; other site 762051001348 putative NAD binding site [chemical binding]; other site 762051001349 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 762051001350 L-serine binding site [chemical binding]; other site 762051001351 ACT domain interface; other site 762051001352 3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355 762051001353 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 762051001354 catalytic residue [active] 762051001355 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 762051001356 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 762051001357 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 762051001358 Walker A/P-loop; other site 762051001359 ATP binding site [chemical binding]; other site 762051001360 Q-loop/lid; other site 762051001361 ABC transporter signature motif; other site 762051001362 Walker B; other site 762051001363 D-loop; other site 762051001364 H-loop/switch region; other site 762051001365 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 762051001366 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 762051001367 ligand binding site [chemical binding]; other site 762051001368 active site 762051001369 UGI interface [polypeptide binding]; other site 762051001370 catalytic site [active] 762051001371 Tubby C 2; Region: Tub_2; cl02043 762051001372 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 762051001373 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 762051001374 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 762051001375 Walker A/P-loop; other site 762051001376 ATP binding site [chemical binding]; other site 762051001377 Q-loop/lid; other site 762051001378 ABC transporter signature motif; other site 762051001379 Walker B; other site 762051001380 D-loop; other site 762051001381 H-loop/switch region; other site 762051001382 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 762051001383 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762051001384 dimer interface [polypeptide binding]; other site 762051001385 conserved gate region; other site 762051001386 putative PBP binding loops; other site 762051001387 ABC-ATPase subunit interface; other site 762051001388 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 762051001389 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 762051001390 substrate binding pocket [chemical binding]; other site 762051001391 membrane-bound complex binding site; other site 762051001392 hinge residues; other site 762051001393 prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597 762051001394 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 762051001395 tetramer interface [polypeptide binding]; other site 762051001396 active site 762051001397 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 762051001398 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 762051001399 THF binding site; other site 762051001400 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 762051001401 substrate binding site [chemical binding]; other site 762051001402 THF binding site; other site 762051001403 zinc-binding site [ion binding]; other site 762051001404 NMT1/THI5 like; Region: NMT1; pfam09084 762051001405 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 762051001406 substrate binding pocket [chemical binding]; other site 762051001407 membrane-bound complex binding site; other site 762051001408 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 762051001409 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 762051001410 Walker A/P-loop; other site 762051001411 ATP binding site [chemical binding]; other site 762051001412 Q-loop/lid; other site 762051001413 ABC transporter signature motif; other site 762051001414 Walker B; other site 762051001415 D-loop; other site 762051001416 H-loop/switch region; other site 762051001417 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 762051001418 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762051001419 dimer interface [polypeptide binding]; other site 762051001420 ABC-ATPase subunit interface; other site 762051001421 putative PBP binding loops; other site 762051001422 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 762051001423 FAD binding site [chemical binding]; other site 762051001424 homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485 762051001425 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 762051001426 S-methylmethionine transporter; Provisional; Region: PRK11387 762051001427 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 762051001428 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 762051001429 Walker A/P-loop; other site 762051001430 ATP binding site [chemical binding]; other site 762051001431 Q-loop/lid; other site 762051001432 ABC transporter signature motif; other site 762051001433 Walker B; other site 762051001434 D-loop; other site 762051001435 H-loop/switch region; other site 762051001436 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 762051001437 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 762051001438 Walker A/P-loop; other site 762051001439 ATP binding site [chemical binding]; other site 762051001440 Q-loop/lid; other site 762051001441 ABC transporter signature motif; other site 762051001442 Walker B; other site 762051001443 D-loop; other site 762051001444 H-loop/switch region; other site 762051001445 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 762051001446 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 762051001447 TM-ABC transporter signature motif; other site 762051001448 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 762051001449 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 762051001450 TM-ABC transporter signature motif; other site 762051001451 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 762051001452 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 762051001453 putative ligand binding site [chemical binding]; other site 762051001454 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 762051001455 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 762051001456 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 762051001457 active site 762051001458 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 762051001459 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 762051001460 Predicted membrane protein [Function unknown]; Region: COG4684 762051001461 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 762051001462 active site 762051001463 P-loop; other site 762051001464 phosphorylation site [posttranslational modification] 762051001465 isoleucyl-tRNA synthetase; Provisional; Region: ileS; PRK13804 762051001466 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 762051001467 active site 762051001468 HIGH motif; other site 762051001469 nucleotide binding site [chemical binding]; other site 762051001470 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 762051001471 active site 762051001472 KMSKS motif; other site 762051001473 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 762051001474 tRNA binding surface [nucleotide binding]; other site 762051001475 anticodon binding site; other site 762051001476 DivIVA protein; Region: DivIVA; pfam05103 762051001477 DivIVA domain; Region: DivI1A_domain; TIGR03544 762051001478 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 762051001479 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 762051001480 RNA binding surface [nucleotide binding]; other site 762051001481 YGGT family; Region: YGGT; pfam02325 762051001482 Protein of unknown function (DUF552); Region: DUF552; pfam04472 762051001483 cell division protein FtsZ; Validated; Region: PRK09330 762051001484 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 762051001485 nucleotide binding site [chemical binding]; other site 762051001486 SulA interaction site; other site 762051001487 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 762051001488 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 762051001489 nucleotide binding site [chemical binding]; other site 762051001490 SHS2 domain inserted in FTSA; Region: SHS2_FTSA; pfam02491 762051001491 Cell division protein FtsA; Region: FtsA; pfam14450 762051001492 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 762051001493 Cell division protein FtsQ; Region: FtsQ; pfam03799 762051001494 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 762051001495 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 762051001496 active site 762051001497 homodimer interface [polypeptide binding]; other site 762051001498 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 762051001499 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 762051001500 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 762051001501 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 762051001502 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 762051001503 Mg++ binding site [ion binding]; other site 762051001504 putative catalytic motif [active] 762051001505 putative substrate binding site [chemical binding]; other site 762051001506 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 762051001507 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 762051001508 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 762051001509 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 762051001510 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 762051001511 MraW methylase family; Region: Methyltransf_5; pfam01795 762051001512 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 762051001513 cell division protein MraZ; Reviewed; Region: PRK00326 762051001514 MraZ protein; Region: MraZ; pfam02381 762051001515 MraZ protein; Region: MraZ; pfam02381 762051001516 Protein of unknown function (DUF4044); Region: DUF4044; pfam13253 762051001517 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 762051001518 DAK2 domain; Region: Dak2; pfam02734 762051001519 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 762051001520 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 762051001521 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 762051001522 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 762051001523 catalytic residues [active] 762051001524 Thiamine pyrophosphokinase; Region: TPK; cd07995 762051001525 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 762051001526 active site 762051001527 dimerization interface [polypeptide binding]; other site 762051001528 thiamine binding site [chemical binding]; other site 762051001529 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 762051001530 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 762051001531 substrate binding site [chemical binding]; other site 762051001532 hexamer interface [polypeptide binding]; other site 762051001533 metal binding site [ion binding]; metal-binding site 762051001534 GTPase RsgA; Reviewed; Region: PRK00098 762051001535 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 762051001536 RNA binding site [nucleotide binding]; other site 762051001537 homodimer interface [polypeptide binding]; other site 762051001538 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 762051001539 GTPase/Zn-binding domain interface [polypeptide binding]; other site 762051001540 GTP/Mg2+ binding site [chemical binding]; other site 762051001541 G4 box; other site 762051001542 G5 box; other site 762051001543 G1 box; other site 762051001544 Switch I region; other site 762051001545 G2 box; other site 762051001546 G3 box; other site 762051001547 Switch II region; other site 762051001548 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 762051001549 Catalytic domain of Protein Kinases; Region: PKc; cd00180 762051001550 active site 762051001551 ATP binding site [chemical binding]; other site 762051001552 substrate binding site [chemical binding]; other site 762051001553 activation loop (A-loop); other site 762051001554 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 762051001555 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 762051001556 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 762051001557 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 762051001558 active site 762051001559 16S rRNA methyltransferase B; Provisional; Region: PRK14902 762051001560 NusB family; Region: NusB; pfam01029 762051001561 putative RNA binding site [nucleotide binding]; other site 762051001562 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 762051001563 S-adenosylmethionine binding site [chemical binding]; other site 762051001564 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 762051001565 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 762051001566 putative active site [active] 762051001567 substrate binding site [chemical binding]; other site 762051001568 putative cosubstrate binding site; other site 762051001569 catalytic site [active] 762051001570 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 762051001571 substrate binding site [chemical binding]; other site 762051001572 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 762051001573 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 762051001574 ATP binding site [chemical binding]; other site 762051001575 putative Mg++ binding site [ion binding]; other site 762051001576 helicase superfamily c-terminal domain; Region: HELICc; smart00490 762051001577 ATP-binding site [chemical binding]; other site 762051001578 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 762051001579 G1 box; other site 762051001580 GTP/Mg2+ binding site [chemical binding]; other site 762051001581 Switch I region; other site 762051001582 G2 box; other site 762051001583 G3 box; other site 762051001584 Switch II region; other site 762051001585 G4 box; other site 762051001586 G5 box; other site 762051001587 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 762051001588 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 762051001589 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 762051001590 Walker A motif; other site 762051001591 ATP binding site [chemical binding]; other site 762051001592 Walker B motif; other site 762051001593 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 762051001594 trigger factor; Provisional; Region: tig; PRK01490 762051001595 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 762051001596 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 762051001597 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 762051001598 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 762051001599 Bacteriophage peptidoglycan hydrolase; Region: Amidase_5; pfam05382 762051001600 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762051001601 acetoin reductases; Region: 23BDH; TIGR02415 762051001602 NAD(P) binding site [chemical binding]; other site 762051001603 active site 762051001604 nicotinamide-nucleotide adenylyltransferase, NadR type; Region: nadR_NMN_Atrans; TIGR01526 762051001605 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 762051001606 active site 762051001607 nucleotide binding site [chemical binding]; other site 762051001608 HIGH motif; other site 762051001609 KMSKS motif; other site 762051001610 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 762051001611 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 762051001612 methionine sulfoxide reductase B; Provisional; Region: PRK00222 762051001613 SelR domain; Region: SelR; pfam01641 762051001614 dipeptidase PepV; Reviewed; Region: PRK07318 762051001615 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 762051001616 active site 762051001617 metal binding site [ion binding]; metal-binding site 762051001618 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 762051001619 putative substrate binding site [chemical binding]; other site 762051001620 putative ATP binding site [chemical binding]; other site 762051001621 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 762051001622 active site 762051001623 putative catalytic site [active] 762051001624 DNA binding site [nucleotide binding] 762051001625 putative phosphate binding site [ion binding]; other site 762051001626 metal binding site A [ion binding]; metal-binding site 762051001627 AP binding site [nucleotide binding]; other site 762051001628 metal binding site B [ion binding]; metal-binding site 762051001629 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 762051001630 active site 762051001631 catalytic site [active] 762051001632 substrate binding site [chemical binding]; other site 762051001633 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 762051001634 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 762051001635 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 762051001636 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 762051001637 active site 762051001638 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 762051001639 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 762051001640 homodimer interface [polypeptide binding]; other site 762051001641 NAD binding pocket [chemical binding]; other site 762051001642 ATP binding pocket [chemical binding]; other site 762051001643 Mg binding site [ion binding]; other site 762051001644 active-site loop [active] 762051001645 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 762051001646 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 762051001647 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 762051001648 protein binding site [polypeptide binding]; other site 762051001649 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 762051001650 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 762051001651 active site 762051001652 (T/H)XGH motif; other site 762051001653 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 762051001654 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 762051001655 S-adenosylmethionine binding site [chemical binding]; other site 762051001656 Uncharacterized protein conserved in bacteria (DUF2129); Region: DUF2129; pfam09902 762051001657 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 762051001658 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 762051001659 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 762051001660 oligomer interface [polypeptide binding]; other site 762051001661 active site 762051001662 metal binding site [ion binding]; metal-binding site 762051001663 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 762051001664 catalytic core [active] 762051001665 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 762051001666 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 762051001667 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 762051001668 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 762051001669 Walker A/P-loop; other site 762051001670 ATP binding site [chemical binding]; other site 762051001671 Q-loop/lid; other site 762051001672 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 762051001673 ABC transporter signature motif; other site 762051001674 Walker B; other site 762051001675 D-loop; other site 762051001676 H-loop/switch region; other site 762051001677 Arginine repressor [Transcription]; Region: ArgR; COG1438 762051001678 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 762051001679 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 762051001680 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 762051001681 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 762051001682 RNA binding surface [nucleotide binding]; other site 762051001683 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 762051001684 S-adenosylmethionine binding site [chemical binding]; other site 762051001685 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 762051001686 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 762051001687 substrate binding pocket [chemical binding]; other site 762051001688 chain length determination region; other site 762051001689 catalytic residues [active] 762051001690 aspartate-rich region 1; other site 762051001691 substrate-Mg2+ binding site; other site 762051001692 active site lid residues [active] 762051001693 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 762051001694 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 762051001695 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 762051001696 generic binding surface II; other site 762051001697 generic binding surface I; other site 762051001698 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 762051001699 putative dimer interface [polypeptide binding]; other site 762051001700 CamS sex pheromone cAM373 precursor; Region: CamS; pfam07537 762051001701 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 762051001702 putative dimer interface [polypeptide binding]; other site 762051001703 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 762051001704 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 762051001705 nucleotide binding pocket [chemical binding]; other site 762051001706 K-X-D-G motif; other site 762051001707 catalytic site [active] 762051001708 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 762051001709 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 762051001710 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 762051001711 Dimer interface [polypeptide binding]; other site 762051001712 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 762051001713 Part of AAA domain; Region: AAA_19; pfam13245 762051001714 Family description; Region: UvrD_C_2; pfam13538 762051001715 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 762051001716 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 762051001717 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 762051001718 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 762051001719 Walker A/P-loop; other site 762051001720 ATP binding site [chemical binding]; other site 762051001721 Q-loop/lid; other site 762051001722 ABC transporter signature motif; other site 762051001723 Walker B; other site 762051001724 D-loop; other site 762051001725 H-loop/switch region; other site 762051001726 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 762051001727 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 762051001728 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 762051001729 Walker A/P-loop; other site 762051001730 ATP binding site [chemical binding]; other site 762051001731 Q-loop/lid; other site 762051001732 ABC transporter signature motif; other site 762051001733 Walker B; other site 762051001734 D-loop; other site 762051001735 H-loop/switch region; other site 762051001736 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 762051001737 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 762051001738 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 762051001739 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 762051001740 hypothetical protein; Provisional; Region: PRK13678 762051001741 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 762051001742 hypothetical protein; Provisional; Region: PRK05473 762051001743 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 762051001744 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 762051001745 motif 1; other site 762051001746 active site 762051001747 motif 2; other site 762051001748 motif 3; other site 762051001749 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 762051001750 DHHA1 domain; Region: DHHA1; pfam02272 762051001751 4-aminobutyrate aminotransferase; Provisional; Region: PRK08593 762051001752 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 762051001753 inhibitor-cofactor binding pocket; inhibition site 762051001754 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762051001755 catalytic residue [active] 762051001756 amino acid transporter; Region: 2A0306; TIGR00909 762051001757 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 762051001758 GntP family permease; Region: GntP_permease; pfam02447 762051001759 fructuronate transporter; Provisional; Region: PRK10034; cl15264 762051001760 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 762051001761 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 762051001762 N- and C-terminal domain interface [polypeptide binding]; other site 762051001763 active site 762051001764 catalytic site [active] 762051001765 metal binding site [ion binding]; metal-binding site 762051001766 carbohydrate binding site [chemical binding]; other site 762051001767 ATP binding site [chemical binding]; other site 762051001768 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 762051001769 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 762051001770 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 762051001771 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 762051001772 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 762051001773 putative active site [active] 762051001774 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 762051001775 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 762051001776 Sugar specificity; other site 762051001777 Pyrimidine base specificity; other site 762051001778 ATP-binding site [chemical binding]; other site 762051001779 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306 762051001780 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 762051001781 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 762051001782 catalytic triad [active] 762051001783 catalytic triad [active] 762051001784 oxyanion hole [active] 762051001785 catabolite control protein A; Region: ccpA; TIGR01481 762051001786 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 762051001787 DNA binding site [nucleotide binding] 762051001788 domain linker motif; other site 762051001789 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 762051001790 dimerization interface [polypeptide binding]; other site 762051001791 effector binding site; other site 762051001792 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 762051001793 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 762051001794 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 762051001795 active site 762051001796 CAAX protease self-immunity; Region: Abi; pfam02517 762051001797 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 762051001798 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 762051001799 active site 762051001800 motif I; other site 762051001801 motif II; other site 762051001802 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 762051001803 SprT homologues; Region: SprT; cl01182 762051001804 hypothetical protein; Provisional; Region: PRK04351 762051001805 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762051001806 dimer interface [polypeptide binding]; other site 762051001807 conserved gate region; other site 762051001808 putative PBP binding loops; other site 762051001809 ABC-ATPase subunit interface; other site 762051001810 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 762051001811 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 762051001812 GAF domain; Region: GAF_2; pfam13185 762051001813 acyl carrier protein; Provisional; Region: acpP; PRK00982 762051001814 putative phosphate acyltransferase; Provisional; Region: PRK05331 762051001815 putative transport protein YifK; Provisional; Region: PRK10746 762051001816 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 762051001817 Domain of unknown function (DUF1934); Region: DUF1934; pfam09148 762051001818 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 762051001819 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 762051001820 Zn2+ binding site [ion binding]; other site 762051001821 Mg2+ binding site [ion binding]; other site 762051001822 x-prolyl-dipeptidyl aminopeptidase; Provisional; Region: PRK05371 762051001823 X-Prolyl dipeptidyl aminopeptidase PepX, N-terminal; Region: PepX_N; cl07696 762051001824 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 762051001825 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 762051001826 benzoate transport; Region: 2A0115; TIGR00895 762051001827 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762051001828 putative substrate translocation pore; other site 762051001829 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 762051001830 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 762051001831 Int/Topo IB signature motif; other site 762051001832 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 762051001833 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 762051001834 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 762051001835 HsdM N-terminal domain; Region: HsdM_N; pfam12161 762051001836 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 762051001837 Methyltransferase domain; Region: Methyltransf_26; pfam13659 762051001838 Transposase; Region: HTH_Tnp_1; cl17663 762051001839 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 762051001840 HTH-like domain; Region: HTH_21; pfam13276 762051001841 Integrase core domain; Region: rve; pfam00665 762051001842 Integrase core domain; Region: rve_2; pfam13333 762051001843 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 762051001844 Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601 762051001845 Aminopeptidase N [Amino acid transport and metabolism]; Region: PepN; COG0308 762051001846 Zn binding site [ion binding]; other site 762051001847 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 762051001848 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_2; cd12172 762051001849 putative ligand binding site [chemical binding]; other site 762051001850 putative NAD binding site [chemical binding]; other site 762051001851 catalytic site [active] 762051001852 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 762051001853 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 762051001854 substrate binding site [chemical binding]; other site 762051001855 ATP binding site [chemical binding]; other site 762051001856 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 762051001857 Transcriptional regulators [Transcription]; Region: PurR; COG1609 762051001858 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 762051001859 DNA binding site [nucleotide binding] 762051001860 domain linker motif; other site 762051001861 Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283 762051001862 putative dimerization interface [polypeptide binding]; other site 762051001863 putative ligand binding site [chemical binding]; other site 762051001864 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 762051001865 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 762051001866 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 762051001867 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 762051001868 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 762051001869 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 762051001870 active site 762051001871 catalytic site [active] 762051001872 Protein of unknown function (DUF3042); Region: DUF3042; pfam11240 762051001873 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 762051001874 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 762051001875 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 762051001876 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 762051001877 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 762051001878 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 762051001879 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 762051001880 E3 interaction surface; other site 762051001881 lipoyl attachment site [posttranslational modification]; other site 762051001882 e3 binding domain; Region: E3_binding; pfam02817 762051001883 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 762051001884 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 762051001885 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 762051001886 alpha subunit interface [polypeptide binding]; other site 762051001887 TPP binding site [chemical binding]; other site 762051001888 heterodimer interface [polypeptide binding]; other site 762051001889 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 762051001890 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 762051001891 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 762051001892 tetramer interface [polypeptide binding]; other site 762051001893 TPP-binding site [chemical binding]; other site 762051001894 heterodimer interface [polypeptide binding]; other site 762051001895 phosphorylation loop region [posttranslational modification] 762051001896 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 762051001897 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 762051001898 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 762051001899 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 762051001900 active site residue [active] 762051001901 adaptor protein; Provisional; Region: PRK02315 762051001902 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 762051001903 ArsC family; Region: ArsC; pfam03960 762051001904 putative catalytic residues [active] 762051001905 thiol/disulfide switch; other site 762051001906 transaminase; Reviewed; Region: PRK08068 762051001907 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 762051001908 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762051001909 homodimer interface [polypeptide binding]; other site 762051001910 catalytic residue [active] 762051001911 Predicted amidohydrolase [General function prediction only]; Region: COG0388 762051001912 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 762051001913 putative active site [active] 762051001914 catalytic triad [active] 762051001915 putative dimer interface [polypeptide binding]; other site 762051001916 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 762051001917 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 762051001918 substrate binding site [chemical binding]; other site 762051001919 oxyanion hole (OAH) forming residues; other site 762051001920 trimer interface [polypeptide binding]; other site 762051001921 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 762051001922 CoenzymeA binding site [chemical binding]; other site 762051001923 subunit interaction site [polypeptide binding]; other site 762051001924 PHB binding site; other site 762051001925 accessory Sec system protein Asp3; Region: acc_sec_asp3; TIGR03711 762051001926 accessory Sec system protein Asp2; Region: acc_sec_asp2; TIGR03712 762051001927 accessory Sec system protein Asp1; Region: acc_sec_asp1; TIGR03713 762051001928 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 762051001929 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 762051001930 active site 762051001931 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 762051001932 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 762051001933 Cl binding site [ion binding]; other site 762051001934 oligomer interface [polypeptide binding]; other site 762051001935 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 762051001936 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 762051001937 Coenzyme A binding pocket [chemical binding]; other site 762051001938 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 762051001939 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 762051001940 Catalytic site [active] 762051001941 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 762051001942 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 762051001943 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 762051001944 active site 762051001945 catalytic site [active] 762051001946 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 762051001947 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 762051001948 ribonuclease P; Reviewed; Region: rnpA; PRK00499 762051001949 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 762051001950 hypothetical protein; Provisional; Region: PRK12378 762051001951 Pseudouridine synthase, Escherichia coli RluE; Region: PseudoU_synth_RluE; cd02566 762051001952 pseudouridine synthase; Region: TIGR00093 762051001953 probable active site [active] 762051001954 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 762051001955 DnaA N-terminal domain; Region: DnaA_N; pfam11638 762051001956 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 762051001957 Walker A motif; other site 762051001958 ATP binding site [chemical binding]; other site 762051001959 Walker B motif; other site 762051001960 arginine finger; other site 762051001961 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 762051001962 DnaA box-binding interface [nucleotide binding]; other site 762051001963 DNA polymerase III subunit beta; Validated; Region: PRK05643 762051001964 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 762051001965 putative DNA binding surface [nucleotide binding]; other site 762051001966 dimer interface [polypeptide binding]; other site 762051001967 beta-clamp/clamp loader binding surface; other site 762051001968 beta-clamp/translesion DNA polymerase binding surface; other site 762051001969 S4 domain; Region: S4_2; pfam13275 762051001970 recombination protein F; Reviewed; Region: recF; PRK00064 762051001971 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 762051001972 Walker A/P-loop; other site 762051001973 ATP binding site [chemical binding]; other site 762051001974 Q-loop/lid; other site 762051001975 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 762051001976 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762051001977 Mg2+ binding site [ion binding]; other site 762051001978 G-X-G motif; other site 762051001979 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 762051001980 anchoring element; other site 762051001981 dimer interface [polypeptide binding]; other site 762051001982 ATP binding site [chemical binding]; other site 762051001983 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 762051001984 active site 762051001985 putative metal-binding site [ion binding]; other site 762051001986 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 762051001987 DNA gyrase subunit A; Validated; Region: PRK05560 762051001988 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 762051001989 CAP-like domain; other site 762051001990 active site 762051001991 primary dimer interface [polypeptide binding]; other site 762051001992 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 762051001993 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 762051001994 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 762051001995 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 762051001996 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 762051001997 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 762051001998 PspC domain; Region: PspC; pfam04024 762051001999 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 762051002000 Predicted transcriptional regulators [Transcription]; Region: COG1695 762051002001 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 762051002002 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762051002003 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762051002004 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 762051002005 dimerization interface [polypeptide binding]; other site 762051002006 Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845 762051002007 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 762051002008 HlyD family secretion protein; Region: HlyD_3; pfam13437 762051002009 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 762051002010 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 762051002011 Walker A/P-loop; other site 762051002012 ATP binding site [chemical binding]; other site 762051002013 Q-loop/lid; other site 762051002014 ABC transporter signature motif; other site 762051002015 Walker B; other site 762051002016 D-loop; other site 762051002017 H-loop/switch region; other site 762051002018 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 762051002019 FtsX-like permease family; Region: FtsX; pfam02687 762051002020 BacA is a bacterial lysin from Enterococcus faecalis that degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. BacA is homologous to the YbfG and YkuG lysins of...; Region: GH25_BacA-like; cd06418 762051002021 active site 762051002022 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 762051002023 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 762051002024 non-specific DNA binding site [nucleotide binding]; other site 762051002025 salt bridge; other site 762051002026 sequence-specific DNA binding site [nucleotide binding]; other site 762051002027 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 762051002028 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762051002029 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762051002030 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 762051002031 dimerization interface [polypeptide binding]; other site 762051002032 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 762051002033 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 762051002034 Coenzyme A binding pocket [chemical binding]; other site 762051002035 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 762051002036 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 762051002037 non-specific DNA binding site [nucleotide binding]; other site 762051002038 salt bridge; other site 762051002039 sequence-specific DNA binding site [nucleotide binding]; other site 762051002040 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762051002041 DNA-binding site [nucleotide binding]; DNA binding site 762051002042 Transcriptional regulators [Transcription]; Region: PurR; COG1609 762051002043 Ligand-binding domain of DNA transcription repressor specific for arabinose (AraR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AraR; cd01541 762051002044 putative dimerization interface [polypeptide binding]; other site 762051002045 putative ligand binding site [chemical binding]; other site 762051002046 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 762051002047 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 762051002048 intersubunit interface [polypeptide binding]; other site 762051002049 active site 762051002050 zinc binding site [ion binding]; other site 762051002051 Na+ binding site [ion binding]; other site 762051002052 L-arabinose isomerase; Provisional; Region: PRK02929 762051002053 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 762051002054 hexamer (dimer of trimers) interface [polypeptide binding]; other site 762051002055 trimer interface [polypeptide binding]; other site 762051002056 substrate binding site [chemical binding]; other site 762051002057 Mn binding site [ion binding]; other site 762051002058 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 762051002059 active site 762051002060 galactoside permease; Reviewed; Region: lacY; PRK09528 762051002061 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762051002062 putative substrate translocation pore; other site 762051002063 L-ribulokinase-like proteins; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-RBK_like; cd07778 762051002064 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 762051002065 putative N- and C-terminal domain interface [polypeptide binding]; other site 762051002066 putative active site [active] 762051002067 MgATP binding site [chemical binding]; other site 762051002068 catalytic site [active] 762051002069 metal binding site [ion binding]; metal-binding site 762051002070 putative carbohydrate binding site [chemical binding]; other site 762051002071 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 762051002072 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 762051002073 intersubunit interface [polypeptide binding]; other site 762051002074 active site 762051002075 Zn2+ binding site [ion binding]; other site 762051002076 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 762051002077 active site 762051002078 catalytic residues [active] 762051002079 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 762051002080 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 762051002081 non-specific DNA binding site [nucleotide binding]; other site 762051002082 salt bridge; other site 762051002083 sequence-specific DNA binding site [nucleotide binding]; other site 762051002084 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 762051002085 H+ Antiporter protein; Region: 2A0121; TIGR00900 762051002086 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762051002087 putative substrate translocation pore; other site 762051002088 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 762051002089 non-specific DNA binding site [nucleotide binding]; other site 762051002090 salt bridge; other site 762051002091 sequence-specific DNA binding site [nucleotide binding]; other site 762051002092 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 762051002093 H+ Antiporter protein; Region: 2A0121; TIGR00900 762051002094 ABC-2 type transporter; Region: ABC2_membrane; cl17235 762051002095 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 762051002096 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 762051002097 Walker A/P-loop; other site 762051002098 ATP binding site [chemical binding]; other site 762051002099 Q-loop/lid; other site 762051002100 ABC transporter signature motif; other site 762051002101 Walker B; other site 762051002102 D-loop; other site 762051002103 H-loop/switch region; other site 762051002104 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196 762051002105 substrate interface [chemical binding]; other site 762051002106 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 762051002107 dimerization interface [polypeptide binding]; other site 762051002108 putative DNA binding site [nucleotide binding]; other site 762051002109 putative Zn2+ binding site [ion binding]; other site 762051002110 NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650 762051002111 active site 762051002112 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 762051002113 active site 762051002114 tetramer interface [polypeptide binding]; other site 762051002115 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 762051002116 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 762051002117 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 762051002118 Transcriptional regulators [Transcription]; Region: PurR; COG1609 762051002119 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 762051002120 DNA binding site [nucleotide binding] 762051002121 domain linker motif; other site 762051002122 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 762051002123 dimerization interface [polypeptide binding]; other site 762051002124 ligand binding site [chemical binding]; other site 762051002125 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 762051002126 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 762051002127 substrate binding site [chemical binding]; other site 762051002128 dimer interface [polypeptide binding]; other site 762051002129 ATP binding site [chemical binding]; other site 762051002130 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 762051002131 tetramer (dimer of dimers) interface [polypeptide binding]; other site 762051002132 active site 762051002133 dimer interface [polypeptide binding]; other site 762051002134 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 762051002135 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 762051002136 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 762051002137 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 762051002138 metal binding site [ion binding]; metal-binding site 762051002139 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 762051002140 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 762051002141 homodimer interface [polypeptide binding]; other site 762051002142 substrate-cofactor binding pocket; other site 762051002143 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762051002144 catalytic residue [active] 762051002145 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 762051002146 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 762051002147 substrate binding pocket [chemical binding]; other site 762051002148 membrane-bound complex binding site; other site 762051002149 hinge residues; other site 762051002150 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762051002151 dimer interface [polypeptide binding]; other site 762051002152 conserved gate region; other site 762051002153 putative PBP binding loops; other site 762051002154 ABC-ATPase subunit interface; other site 762051002155 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 762051002156 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 762051002157 Walker A/P-loop; other site 762051002158 ATP binding site [chemical binding]; other site 762051002159 Q-loop/lid; other site 762051002160 ABC transporter signature motif; other site 762051002161 Walker B; other site 762051002162 D-loop; other site 762051002163 H-loop/switch region; other site 762051002164 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 762051002165 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 762051002166 Spore germination protein; Region: Spore_permease; cl17796 762051002167 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 762051002168 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 762051002169 dimer interface [polypeptide binding]; other site 762051002170 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762051002171 catalytic residue [active] 762051002172 cystathionine beta-lyase; Provisional; Region: PRK07671 762051002173 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 762051002174 homodimer interface [polypeptide binding]; other site 762051002175 substrate-cofactor binding pocket; other site 762051002176 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762051002177 catalytic residue [active] 762051002178 serine O-acetyltransferase; Region: cysE; TIGR01172 762051002179 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 762051002180 trimer interface [polypeptide binding]; other site 762051002181 active site 762051002182 substrate binding site [chemical binding]; other site 762051002183 CoA binding site [chemical binding]; other site 762051002184 Predicted permeases [General function prediction only]; Region: RarD; COG2962 762051002185 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 762051002186 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 762051002187 non-specific DNA binding site [nucleotide binding]; other site 762051002188 salt bridge; other site 762051002189 sequence-specific DNA binding site [nucleotide binding]; other site 762051002190 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 762051002191 CAAX protease self-immunity; Region: Abi; pfam02517 762051002192 CAAX protease self-immunity; Region: Abi; pfam02517 762051002193 Bacteriocin class II with double-glycine leader peptide; Region: Bacteriocin_IIc; pfam10439 762051002194 CAAX protease self-immunity; Region: Abi; pfam02517 762051002195 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 762051002196 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 762051002197 non-specific DNA binding site [nucleotide binding]; other site 762051002198 salt bridge; other site 762051002199 sequence-specific DNA binding site [nucleotide binding]; other site 762051002200 CAAX protease self-immunity; Region: Abi; pfam02517 762051002201 Integral membrane protein DUF95; Region: DUF95; pfam01944 762051002202 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 762051002203 putative active site [active] 762051002204 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 762051002205 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 762051002206 non-specific DNA binding site [nucleotide binding]; other site 762051002207 salt bridge; other site 762051002208 sequence-specific DNA binding site [nucleotide binding]; other site 762051002209 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 762051002210 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 762051002211 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 762051002212 non-specific DNA binding site [nucleotide binding]; other site 762051002213 salt bridge; other site 762051002214 sequence-specific DNA binding site [nucleotide binding]; other site 762051002215 CAAX protease self-immunity; Region: Abi; pfam02517 762051002216 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 762051002217 Coenzyme A binding pocket [chemical binding]; other site 762051002218 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 762051002219 non-specific DNA binding site [nucleotide binding]; other site 762051002220 salt bridge; other site 762051002221 sequence-specific DNA binding site [nucleotide binding]; other site 762051002222 cytochrome aa3 quinol oxidase, subunit I; Region: QoxB; TIGR02882 762051002223 Enterocin A Immunity; Region: EntA_Immun; pfam08951 762051002224 Domain of unknown function DUF87; Region: DUF87; pfam01935 762051002225 AAA-like domain; Region: AAA_10; pfam12846 762051002226 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 762051002227 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 762051002228 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 762051002229 Predicted membrane protein [Function unknown]; Region: COG1511 762051002230 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 762051002231 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 762051002232 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 762051002233 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 762051002234 non-specific DNA binding site [nucleotide binding]; other site 762051002235 salt bridge; other site 762051002236 sequence-specific DNA binding site [nucleotide binding]; other site 762051002237 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 762051002238 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 762051002239 Walker A/P-loop; other site 762051002240 ATP binding site [chemical binding]; other site 762051002241 Q-loop/lid; other site 762051002242 ABC transporter signature motif; other site 762051002243 Walker B; other site 762051002244 D-loop; other site 762051002245 H-loop/switch region; other site 762051002246 The Eukaryotic (Putative) Sterol Transporter (EST) Family; Region: 2A060602; TIGR00918 762051002247 Protein of unknown function (DUF975); Region: DUF975; cl10504 762051002248 tyrosyl-tRNA synthetase; Provisional; Region: PRK13354 762051002249 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 762051002250 active site 762051002251 HIGH motif; other site 762051002252 dimer interface [polypeptide binding]; other site 762051002253 KMSKS motif; other site 762051002254 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 762051002255 RNA binding surface [nucleotide binding]; other site 762051002256 D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186 762051002257 D-lactate dehydrogenase; Validated; Region: PRK08605 762051002258 homodimer interface [polypeptide binding]; other site 762051002259 ligand binding site [chemical binding]; other site 762051002260 NAD binding site [chemical binding]; other site 762051002261 catalytic site [active] 762051002262 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 762051002263 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 762051002264 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762051002265 putative substrate translocation pore; other site 762051002266 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 762051002267 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 762051002268 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 762051002269 DNA binding residues [nucleotide binding] 762051002270 putative dimer interface [polypeptide binding]; other site 762051002271 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 762051002272 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 762051002273 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 762051002274 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 762051002275 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 762051002276 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 762051002277 NADH(P)-binding; Region: NAD_binding_10; pfam13460 762051002278 NAD(P) binding site [chemical binding]; other site 762051002279 putative active site [active] 762051002280 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 762051002281 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 762051002282 active site 762051002283 motif I; other site 762051002284 motif II; other site 762051002285 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 762051002286 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 762051002287 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 762051002288 short chain dehydrogenase; Provisional; Region: PRK06914 762051002289 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 762051002290 NADP binding site [chemical binding]; other site 762051002291 active site 762051002292 steroid binding site; other site 762051002293 hypothetical protein; Provisional; Region: PRK10281 762051002294 2-hydroxyacid dehydrogenase; Provisional; Region: PRK08410 762051002295 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162 762051002296 putative ligand binding site [chemical binding]; other site 762051002297 putative NAD binding site [chemical binding]; other site 762051002298 catalytic site [active] 762051002299 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 762051002300 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762051002301 NAD(P) binding site [chemical binding]; other site 762051002302 active site 762051002303 Surface antigen [General function prediction only]; Region: COG3942 762051002304 CHAP domain; Region: CHAP; cl17642 762051002305 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352 762051002306 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762051002307 ATP binding site [chemical binding]; other site 762051002308 Mg2+ binding site [ion binding]; other site 762051002309 G-X-G motif; other site 762051002310 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 762051002311 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 762051002312 active site 762051002313 phosphorylation site [posttranslational modification] 762051002314 intermolecular recognition site; other site 762051002315 dimerization interface [polypeptide binding]; other site 762051002316 LytTr DNA-binding domain; Region: LytTR; cl04498 762051002317 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 762051002318 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 762051002319 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 762051002320 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 762051002321 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 762051002322 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 762051002323 transcriptional antiterminator BglG; Provisional; Region: PRK09772 762051002324 CAT RNA binding domain; Region: CAT_RBD; smart01061 762051002325 PRD domain; Region: PRD; pfam00874 762051002326 PRD domain; Region: PRD; pfam00874 762051002327 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 762051002328 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 762051002329 active site turn [active] 762051002330 phosphorylation site [posttranslational modification] 762051002331 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 762051002332 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 762051002333 HPr interaction site; other site 762051002334 glycerol kinase (GK) interaction site [polypeptide binding]; other site 762051002335 active site 762051002336 phosphorylation site [posttranslational modification] 762051002337 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 762051002338 beta-galactosidase; Region: BGL; TIGR03356 762051002339 Protein of unknown function (DUF1440); Region: DUF1440; pfam07274 762051002340 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 762051002341 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 762051002342 ligand binding site [chemical binding]; other site 762051002343 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl17272 762051002344 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762051002345 DNA-binding site [nucleotide binding]; DNA binding site 762051002346 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 762051002347 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 762051002348 Walker A/P-loop; other site 762051002349 ATP binding site [chemical binding]; other site 762051002350 Q-loop/lid; other site 762051002351 ABC transporter signature motif; other site 762051002352 Walker B; other site 762051002353 D-loop; other site 762051002354 H-loop/switch region; other site 762051002355 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 762051002356 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 762051002357 Walker A/P-loop; other site 762051002358 ATP binding site [chemical binding]; other site 762051002359 Q-loop/lid; other site 762051002360 ABC transporter signature motif; other site 762051002361 Walker B; other site 762051002362 D-loop; other site 762051002363 H-loop/switch region; other site 762051002364 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 762051002365 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 762051002366 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 762051002367 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 762051002368 active site 762051002369 catalytic tetrad [active] 762051002370 Metal binding protein TroA_b. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: TroA_b; cd01020 762051002371 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 762051002372 metal binding site [ion binding]; metal-binding site 762051002373 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 762051002374 putative DNA binding site [nucleotide binding]; other site 762051002375 putative Zn2+ binding site [ion binding]; other site 762051002376 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 762051002377 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 762051002378 Walker A/P-loop; other site 762051002379 ATP binding site [chemical binding]; other site 762051002380 Q-loop/lid; other site 762051002381 ABC transporter signature motif; other site 762051002382 Walker B; other site 762051002383 D-loop; other site 762051002384 H-loop/switch region; other site 762051002385 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 762051002386 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 762051002387 active site 762051002388 phosphorylation site [posttranslational modification] 762051002389 intermolecular recognition site; other site 762051002390 dimerization interface [polypeptide binding]; other site 762051002391 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 762051002392 DNA binding site [nucleotide binding] 762051002393 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 762051002394 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762051002395 ATP binding site [chemical binding]; other site 762051002396 Mg2+ binding site [ion binding]; other site 762051002397 G-X-G motif; other site 762051002398 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 762051002399 ABC-type transport system involved in cytochrome c biogenesis, ATPase component [Posttranslational modification, protein turnover, chaperones]; Region: CcmA; COG4133 762051002400 Walker A/P-loop; other site 762051002401 ATP binding site [chemical binding]; other site 762051002402 Q-loop/lid; other site 762051002403 ABC transporter signature motif; other site 762051002404 Walker B; other site 762051002405 D-loop; other site 762051002406 H-loop/switch region; other site 762051002407 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 762051002408 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 762051002409 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 762051002410 Major Facilitator Superfamily; Region: MFS_1; pfam07690 762051002411 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762051002412 putative substrate translocation pore; other site 762051002413 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 762051002414 Mrr N-terminal domain; Region: Mrr_N; pfam14338 762051002415 Restriction endonuclease; Region: Mrr_cat; pfam04471 762051002416 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 762051002417 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 762051002418 active site 762051002419 phosphorylation site [posttranslational modification] 762051002420 intermolecular recognition site; other site 762051002421 dimerization interface [polypeptide binding]; other site 762051002422 LytTr DNA-binding domain; Region: LytTR; cl04498 762051002423 Protein of unknown function (DUF2968); Region: DUF2968; pfam11180 762051002424 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762051002425 ATP binding site [chemical binding]; other site 762051002426 Mg2+ binding site [ion binding]; other site 762051002427 G-X-G motif; other site 762051002428 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 762051002429 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 762051002430 Walker A/P-loop; other site 762051002431 ATP binding site [chemical binding]; other site 762051002432 Q-loop/lid; other site 762051002433 ABC transporter signature motif; other site 762051002434 Walker B; other site 762051002435 D-loop; other site 762051002436 H-loop/switch region; other site 762051002437 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 762051002438 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 762051002439 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4200 762051002440 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 762051002441 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 762051002442 ATP binding site [chemical binding]; other site 762051002443 putative Mg++ binding site [ion binding]; other site 762051002444 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 762051002445 nucleotide binding region [chemical binding]; other site 762051002446 ATP-binding site [chemical binding]; other site 762051002447 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 762051002448 HRDC domain; Region: HRDC; pfam00570 762051002449 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 762051002450 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 762051002451 non-specific DNA binding site [nucleotide binding]; other site 762051002452 salt bridge; other site 762051002453 sequence-specific DNA binding site [nucleotide binding]; other site 762051002454 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 762051002455 non-specific DNA binding site [nucleotide binding]; other site 762051002456 salt bridge; other site 762051002457 sequence-specific DNA binding site [nucleotide binding]; other site 762051002458 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 762051002459 polymerase nucleotide-binding site; other site 762051002460 DNA-binding residues [nucleotide binding]; DNA binding site 762051002461 nucleotide binding site [chemical binding]; other site 762051002462 primase nucleotide-binding site [nucleotide binding]; other site 762051002463 Primase C terminal 1 (PriCT-1); Region: PriCT_1; smart00942 762051002464 Virulence-associated protein E; Region: VirE; pfam05272 762051002465 Protein of unknown function (DUF722); Region: DUF722; pfam05263 762051002466 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 762051002467 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 762051002468 active site 762051002469 Phage terminase, small subunit; Region: Terminase_4; pfam05119 762051002470 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 762051002471 Phlebovirus glycoprotein G2; Region: Phlebovirus_G2; pfam07245 762051002472 Phage-related protein [Function unknown]; Region: COG4695 762051002473 Phage portal protein; Region: Phage_portal; pfam04860 762051002474 Caudovirus prohead protease; Region: Peptidase_U35; pfam04586 762051002475 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 762051002476 Phage capsid family; Region: Phage_capsid; pfam05065 762051002477 Head-Tail Connector Proteins gp6 and gp15, and similar proteins; Region: gp6_gp15_like; cl12049 762051002478 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 762051002479 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 762051002480 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 762051002481 Int/Topo IB signature motif; other site 762051002482 T5orf172 domain; Region: T5orf172; pfam10544 762051002483 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 762051002484 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 762051002485 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 762051002486 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 762051002487 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 762051002488 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 762051002489 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 762051002490 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 762051002491 putative metal binding site [ion binding]; other site 762051002492 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 762051002493 thiamine phosphate binding site [chemical binding]; other site 762051002494 active site 762051002495 pyrophosphate binding site [ion binding]; other site 762051002496 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 762051002497 thiS-thiF/thiG interaction site; other site 762051002498 thiamine biosynthesis protein ThiF; Provisional; Region: PRK08644 762051002499 E1_ThiF_like. Member of superfamily of activating enzymes (E1) of the ubiquitin-like proteins. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like substrate, on...; Region: E1_ThiF_like; cd01487 762051002500 putative ATP binding site [chemical binding]; other site 762051002501 putative substrate interface [chemical binding]; other site 762051002502 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 762051002503 ThiS interaction site; other site 762051002504 putative active site [active] 762051002505 tetramer interface [polypeptide binding]; other site 762051002506 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762051002507 D-galactonate transporter; Region: 2A0114; TIGR00893 762051002508 putative substrate translocation pore; other site 762051002509 allantoate amidohydrolase; Reviewed; Region: PRK09290 762051002510 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 762051002511 active site 762051002512 metal binding site [ion binding]; metal-binding site 762051002513 dimer interface [polypeptide binding]; other site 762051002514 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 762051002515 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 762051002516 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 762051002517 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK06079 762051002518 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 762051002519 NAD binding site [chemical binding]; other site 762051002520 homotetramer interface [polypeptide binding]; other site 762051002521 homodimer interface [polypeptide binding]; other site 762051002522 substrate binding site [chemical binding]; other site 762051002523 active site 762051002524 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 762051002525 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762051002526 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762051002527 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762051002528 dimerization interface [polypeptide binding]; other site 762051002529 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 762051002530 Protein of unknown function (DUF805); Region: DUF805; pfam05656 762051002531 acetoin reductase; Validated; Region: PRK08643 762051002532 meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366 762051002533 NAD binding site [chemical binding]; other site 762051002534 homotetramer interface [polypeptide binding]; other site 762051002535 homodimer interface [polypeptide binding]; other site 762051002536 active site 762051002537 substrate binding site [chemical binding]; other site 762051002538 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 762051002539 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 762051002540 non-specific DNA binding site [nucleotide binding]; other site 762051002541 salt bridge; other site 762051002542 sequence-specific DNA binding site [nucleotide binding]; other site 762051002543 GtrA-like protein; Region: GtrA; pfam04138 762051002544 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 762051002545 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 762051002546 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 762051002547 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 762051002548 Malic enzyme, N-terminal domain; Region: malic; pfam00390 762051002549 Malic enzyme, NAD binding domain; Region: Malic_M; smart00919 762051002550 NAD(P) binding pocket [chemical binding]; other site 762051002551 [citrate (pro-3S)-lyase] ligase; Region: cit_ly_ligase; TIGR00124 762051002552 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 762051002553 active site 762051002554 nucleotide binding site [chemical binding]; other site 762051002555 HIGH motif; other site 762051002556 KMSKS motif; other site 762051002557 citrate lyase subunit gamma; Provisional; Region: PRK13253 762051002558 citrate lyase, beta subunit; Region: citE; TIGR01588 762051002559 Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051 762051002560 Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase; Region: CitX; cl01498 762051002561 ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; cl00768 762051002562 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 762051002563 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 762051002564 nucleophilic elbow; other site 762051002565 catalytic triad; other site 762051002566 2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390 762051002567 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 762051002568 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 762051002569 putative catalytic cysteine [active] 762051002570 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 762051002571 putative active site [active] 762051002572 metal binding site [ion binding]; metal-binding site 762051002573 Predicted membrane protein [Function unknown]; Region: COG1511 762051002574 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 762051002575 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 762051002576 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 762051002577 Predicted transcriptional regulator [Transcription]; Region: COG1959 762051002578 Transcriptional regulator; Region: Rrf2; pfam02082 762051002579 Transcriptional regulator; Region: Rrf2; cl17282 762051002580 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 762051002581 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 762051002582 nucleotide binding site [chemical binding]; other site 762051002583 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 762051002584 MarR family; Region: MarR; pfam01047 762051002585 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 762051002586 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 762051002587 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 762051002588 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 762051002589 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 762051002590 putative NAD(P) binding site [chemical binding]; other site 762051002591 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 762051002592 Putative ClC chloride channel. Clc proteins are putative halogen ion (Cl-, Br- and I-) transporters found in eubacteria. They belong to the ClC superfamily of halogen ion channels, which share a unique double-barreled architecture and voltage-dependent...; Region: ClC_like; cd01033 762051002593 putative ion selectivity filter; other site 762051002594 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 762051002595 putative pore gating glutamate residue; other site 762051002596 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 762051002597 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 762051002598 non-specific DNA binding site [nucleotide binding]; other site 762051002599 salt bridge; other site 762051002600 sequence-specific DNA binding site [nucleotide binding]; other site 762051002601 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 762051002602 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 762051002603 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 762051002604 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 762051002605 ABC transporter; Region: ABC_tran_2; pfam12848 762051002606 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 762051002607 Biotin operon repressor [Transcription]; Region: BirA; COG1654 762051002608 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 762051002609 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 762051002610 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 762051002611 BioY family; Region: BioY; pfam02632 762051002612 AAA domain; Region: AAA_17; pfam13207 762051002613 alanine racemase; Reviewed; Region: alr; PRK00053 762051002614 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 762051002615 active site 762051002616 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 762051002617 dimer interface [polypeptide binding]; other site 762051002618 substrate binding site [chemical binding]; other site 762051002619 catalytic residues [active] 762051002620 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 762051002621 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 762051002622 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 762051002623 putative active site [active] 762051002624 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 762051002625 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 762051002626 Walker A/P-loop; other site 762051002627 ATP binding site [chemical binding]; other site 762051002628 Q-loop/lid; other site 762051002629 ABC transporter signature motif; other site 762051002630 Walker B; other site 762051002631 D-loop; other site 762051002632 H-loop/switch region; other site 762051002633 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 762051002634 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 762051002635 substrate binding pocket [chemical binding]; other site 762051002636 membrane-bound complex binding site; other site 762051002637 hinge residues; other site 762051002638 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 762051002639 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762051002640 dimer interface [polypeptide binding]; other site 762051002641 conserved gate region; other site 762051002642 putative PBP binding loops; other site 762051002643 ABC-ATPase subunit interface; other site 762051002644 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762051002645 dimer interface [polypeptide binding]; other site 762051002646 conserved gate region; other site 762051002647 putative PBP binding loops; other site 762051002648 ABC-ATPase subunit interface; other site 762051002649 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 762051002650 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 762051002651 peptide binding site [polypeptide binding]; other site 762051002652 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 762051002653 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 762051002654 peptide binding site [polypeptide binding]; other site 762051002655 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 762051002656 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762051002657 dimer interface [polypeptide binding]; other site 762051002658 conserved gate region; other site 762051002659 putative PBP binding loops; other site 762051002660 ABC-ATPase subunit interface; other site 762051002661 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 762051002662 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 762051002663 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762051002664 dimer interface [polypeptide binding]; other site 762051002665 conserved gate region; other site 762051002666 putative PBP binding loops; other site 762051002667 ABC-ATPase subunit interface; other site 762051002668 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 762051002669 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 762051002670 Walker A/P-loop; other site 762051002671 ATP binding site [chemical binding]; other site 762051002672 Q-loop/lid; other site 762051002673 ABC transporter signature motif; other site 762051002674 Walker B; other site 762051002675 D-loop; other site 762051002676 H-loop/switch region; other site 762051002677 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 762051002678 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 762051002679 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 762051002680 Walker A/P-loop; other site 762051002681 ATP binding site [chemical binding]; other site 762051002682 Q-loop/lid; other site 762051002683 ABC transporter signature motif; other site 762051002684 Walker B; other site 762051002685 D-loop; other site 762051002686 H-loop/switch region; other site 762051002687 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 762051002688 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 762051002689 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 762051002690 active site 762051002691 Zn binding site [ion binding]; other site 762051002692 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 762051002693 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 762051002694 Aspartase; Region: Aspartase; cd01357 762051002695 active sites [active] 762051002696 tetramer interface [polypeptide binding]; other site 762051002697 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 762051002698 tetramer (dimer of dimers) interface [polypeptide binding]; other site 762051002699 active site 762051002700 dimer interface [polypeptide binding]; other site 762051002701 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 762051002702 Coenzyme A binding pocket [chemical binding]; other site 762051002703 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 762051002704 trimer interface [polypeptide binding]; other site 762051002705 active site 762051002706 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 762051002707 nudix motif; other site 762051002708 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 762051002709 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 762051002710 active site 762051002711 metal binding site [ion binding]; metal-binding site 762051002712 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 762051002713 DNA repair protein RadA; Provisional; Region: PRK11823 762051002714 Walker A motif/ATP binding site; other site 762051002715 ATP binding site [chemical binding]; other site 762051002716 Walker B motif; other site 762051002717 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 762051002718 MMPL family; Region: MMPL; pfam03176 762051002719 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 762051002720 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 762051002721 Histidine kinase; Region: HisKA_3; pfam07730 762051002722 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762051002723 ATP binding site [chemical binding]; other site 762051002724 Mg2+ binding site [ion binding]; other site 762051002725 G-X-G motif; other site 762051002726 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 762051002727 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 762051002728 active site 762051002729 phosphorylation site [posttranslational modification] 762051002730 intermolecular recognition site; other site 762051002731 dimerization interface [polypeptide binding]; other site 762051002732 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 762051002733 DNA binding residues [nucleotide binding] 762051002734 dimerization interface [polypeptide binding]; other site 762051002735 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 762051002736 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 762051002737 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 762051002738 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 762051002739 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 762051002740 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 762051002741 active site 762051002742 HIGH motif; other site 762051002743 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 762051002744 active site 762051002745 KMSKS motif; other site 762051002746 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 762051002747 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 762051002748 putative NAD(P) binding site [chemical binding]; other site 762051002749 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 762051002750 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 762051002751 NAD binding site [chemical binding]; other site 762051002752 substrate binding site [chemical binding]; other site 762051002753 catalytic Zn binding site [ion binding]; other site 762051002754 tetramer interface [polypeptide binding]; other site 762051002755 structural Zn binding site [ion binding]; other site 762051002756 putative metalloenzyme radical SAM/SPASM domain maturase; Region: rSAM_Geo_metal; TIGR04311 762051002757 Uncharacterized conserved protein [Function unknown]; Region: COG1912 762051002758 hypothetical protein; Provisional; Region: PRK13661 762051002759 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 762051002760 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 762051002761 Walker A/P-loop; other site 762051002762 ATP binding site [chemical binding]; other site 762051002763 Q-loop/lid; other site 762051002764 ABC transporter signature motif; other site 762051002765 Walker B; other site 762051002766 D-loop; other site 762051002767 H-loop/switch region; other site 762051002768 ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558 762051002769 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 762051002770 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 762051002771 Walker A/P-loop; other site 762051002772 ATP binding site [chemical binding]; other site 762051002773 Q-loop/lid; other site 762051002774 ABC transporter signature motif; other site 762051002775 Walker B; other site 762051002776 D-loop; other site 762051002777 H-loop/switch region; other site 762051002778 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 762051002779 dipeptidase PepV; Reviewed; Region: PRK07318 762051002780 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 762051002781 active site 762051002782 metal binding site [ion binding]; metal-binding site 762051002783 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 762051002784 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 762051002785 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 762051002786 dimer interface [polypeptide binding]; other site 762051002787 ssDNA binding site [nucleotide binding]; other site 762051002788 tetramer (dimer of dimers) interface [polypeptide binding]; other site 762051002789 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 762051002790 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 762051002791 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 762051002792 DHH family; Region: DHH; pfam01368 762051002793 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 762051002794 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 762051002795 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 762051002796 replicative DNA helicase; Region: DnaB; TIGR00665 762051002797 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 762051002798 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 762051002799 Walker A motif; other site 762051002800 ATP binding site [chemical binding]; other site 762051002801 Walker B motif; other site 762051002802 DNA binding loops [nucleotide binding] 762051002803 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 762051002804 homotrimer interaction site [polypeptide binding]; other site 762051002805 putative active site [active] 762051002806 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 762051002807 putative deacylase active site [active] 762051002808 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 762051002809 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762051002810 DNA-binding site [nucleotide binding]; DNA binding site 762051002811 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 762051002812 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 762051002813 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 762051002814 non-specific DNA binding site [nucleotide binding]; other site 762051002815 salt bridge; other site 762051002816 sequence-specific DNA binding site [nucleotide binding]; other site 762051002817 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762051002818 C factor cell-cell signaling protein; Provisional; Region: PRK09009 762051002819 NAD(P) binding site [chemical binding]; other site 762051002820 active site 762051002821 putative phosphoketolase; Provisional; Region: PRK05261 762051002822 XFP N-terminal domain; Region: XFP_N; pfam09364 762051002823 XFP C-terminal domain; Region: XFP_C; pfam09363 762051002824 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 762051002825 nudix motif; other site 762051002826 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762051002827 Major Facilitator Superfamily; Region: MFS_1; pfam07690 762051002828 putative substrate translocation pore; other site 762051002829 sugar phosphate phosphatase; Provisional; Region: PRK10513 762051002830 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 762051002831 active site 762051002832 motif I; other site 762051002833 motif II; other site 762051002834 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 762051002835 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 762051002836 dimer interface [polypeptide binding]; other site 762051002837 catalytic triad [active] 762051002838 peroxidatic and resolving cysteines [active] 762051002839 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 762051002840 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 762051002841 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 762051002842 active site 762051002843 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 762051002844 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 762051002845 active site 762051002846 phosphorylation site [posttranslational modification] 762051002847 intermolecular recognition site; other site 762051002848 dimerization interface [polypeptide binding]; other site 762051002849 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 762051002850 DNA binding site [nucleotide binding] 762051002851 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 762051002852 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 762051002853 dimerization interface [polypeptide binding]; other site 762051002854 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 762051002855 putative active site [active] 762051002856 heme pocket [chemical binding]; other site 762051002857 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 762051002858 dimer interface [polypeptide binding]; other site 762051002859 phosphorylation site [posttranslational modification] 762051002860 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762051002861 ATP binding site [chemical binding]; other site 762051002862 Mg2+ binding site [ion binding]; other site 762051002863 G-X-G motif; other site 762051002864 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 762051002865 YycH protein; Region: YycH; pfam07435 762051002866 YycH protein; Region: YycI; cl02015 762051002867 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 762051002868 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 762051002869 protein binding site [polypeptide binding]; other site 762051002870 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 762051002871 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 762051002872 dimer interface [polypeptide binding]; other site 762051002873 substrate binding site [chemical binding]; other site 762051002874 ATP binding site [chemical binding]; other site 762051002875 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762051002876 Major Facilitator Superfamily; Region: MFS_1; pfam07690 762051002877 putative substrate translocation pore; other site 762051002878 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 762051002879 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 762051002880 minor groove reading motif; other site 762051002881 helix-hairpin-helix signature motif; other site 762051002882 substrate binding pocket [chemical binding]; other site 762051002883 active site 762051002884 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 762051002885 DNA binding and oxoG recognition site [nucleotide binding] 762051002886 Domain of unknown function DUF20; Region: UPF0118; pfam01594 762051002887 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 762051002888 Predicted transcriptional regulators [Transcription]; Region: COG1695 762051002889 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 762051002890 hypothetical protein; Validated; Region: PRK07668 762051002891 TRAM domain; Region: TRAM; pfam01938 762051002892 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 762051002893 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 762051002894 S-adenosylmethionine binding site [chemical binding]; other site 762051002895 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 762051002896 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 762051002897 ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464 762051002898 Walker A motif; other site 762051002899 ATP binding site [chemical binding]; other site 762051002900 Walker B motif; other site 762051002901 arginine finger; other site 762051002902 UvrB/uvrC motif; Region: UVR; pfam02151 762051002903 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 762051002904 Walker A motif; other site 762051002905 ATP binding site [chemical binding]; other site 762051002906 Walker B motif; other site 762051002907 arginine finger; other site 762051002908 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 762051002909 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 762051002910 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762051002911 DNA-binding site [nucleotide binding]; DNA binding site 762051002912 UTRA domain; Region: UTRA; pfam07702 762051002913 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 762051002914 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 762051002915 glycerol kinase (GK) interaction site [polypeptide binding]; other site 762051002916 active site 762051002917 HPr interaction site; other site 762051002918 phosphorylation site [posttranslational modification] 762051002919 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 762051002920 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 762051002921 active site turn [active] 762051002922 phosphorylation site [posttranslational modification] 762051002923 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 762051002924 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 762051002925 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 762051002926 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 762051002927 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 762051002928 beta-phosphoglucomutase; Region: bPGM; TIGR01990 762051002929 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 762051002930 motif II; other site 762051002931 Membrane transport protein; Region: Mem_trans; cl09117 762051002932 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 762051002933 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 762051002934 NAD binding site [chemical binding]; other site 762051002935 sensory histidine kinase DcuS; Provisional; Region: PRK11086 762051002936 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762051002937 ATP binding site [chemical binding]; other site 762051002938 Mg2+ binding site [ion binding]; other site 762051002939 G-X-G motif; other site 762051002940 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 762051002941 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 762051002942 active site 762051002943 phosphorylation site [posttranslational modification] 762051002944 intermolecular recognition site; other site 762051002945 dimerization interface [polypeptide binding]; other site 762051002946 37-kD nucleoid-associated bacterial protein; Region: NA37; cl15473 762051002947 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 762051002948 nudix motif; other site 762051002949 Protein of unknown function (DUF1810); Region: DUF1810; cl02370 762051002950 Ketopantoate reductase [Coenzyme metabolism]; Region: ApbA; COG1893 762051002951 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 762051002952 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 762051002953 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 762051002954 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 762051002955 active site 762051002956 HIGH motif; other site 762051002957 dimer interface [polypeptide binding]; other site 762051002958 KMSKS motif; other site 762051002959 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 762051002960 lysine transporter; Provisional; Region: PRK10836 762051002961 DNA topoisomerase I; Validated; Region: PRK05582 762051002962 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 762051002963 active site 762051002964 interdomain interaction site; other site 762051002965 putative metal-binding site [ion binding]; other site 762051002966 nucleotide binding site [chemical binding]; other site 762051002967 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 762051002968 domain I; other site 762051002969 DNA binding groove [nucleotide binding] 762051002970 phosphate binding site [ion binding]; other site 762051002971 domain II; other site 762051002972 domain III; other site 762051002973 nucleotide binding site [chemical binding]; other site 762051002974 catalytic site [active] 762051002975 domain IV; other site 762051002976 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 762051002977 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 762051002978 Protein of unknown function (DUF1146); Region: DUF1146; cl11486 762051002979 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 762051002980 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 762051002981 substrate binding site [chemical binding]; other site 762051002982 zinc-binding site [ion binding]; other site 762051002983 rod shape-determining protein MreB; Provisional; Region: PRK13930 762051002984 MreB and similar proteins; Region: MreB_like; cd10225 762051002985 nucleotide binding site [chemical binding]; other site 762051002986 Mg binding site [ion binding]; other site 762051002987 putative protofilament interaction site [polypeptide binding]; other site 762051002988 RodZ interaction site [polypeptide binding]; other site 762051002989 Protein of unknown function (DUF2969); Region: DUF2969; pfam11184 762051002990 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 762051002991 Protein of unknown function (DUF2785); Region: DUF2785; pfam10978 762051002992 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 762051002993 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 762051002994 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 762051002995 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 762051002996 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 762051002997 non-specific DNA binding site [nucleotide binding]; other site 762051002998 salt bridge; other site 762051002999 sequence-specific DNA binding site [nucleotide binding]; other site 762051003000 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 762051003001 Ligand Binding Site [chemical binding]; other site 762051003002 recombination factor protein RarA; Reviewed; Region: PRK13342 762051003003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 762051003004 Walker A motif; other site 762051003005 ATP binding site [chemical binding]; other site 762051003006 Walker B motif; other site 762051003007 arginine finger; other site 762051003008 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 762051003009 Protein of unknown function (DUF1694); Region: DUF1694; pfam07997 762051003010 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 762051003011 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 762051003012 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 762051003013 RNA binding surface [nucleotide binding]; other site 762051003014 septation ring formation regulator EzrA; Provisional; Region: PRK04778 762051003015 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 762051003016 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 762051003017 amino acid transporter; Region: 2A0306; TIGR00909 762051003018 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 762051003019 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 762051003020 active site 762051003021 aromatic amino acid aminotransferase; Validated; Region: PRK07309 762051003022 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 762051003023 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762051003024 homodimer interface [polypeptide binding]; other site 762051003025 catalytic residue [active] 762051003026 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 762051003027 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 762051003028 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 762051003029 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 762051003030 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 762051003031 active site 762051003032 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 762051003033 dimer interface [polypeptide binding]; other site 762051003034 substrate binding site [chemical binding]; other site 762051003035 catalytic residues [active] 762051003036 PemK-like protein; Region: PemK; pfam02452 762051003037 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 762051003038 Acyltransferase family; Region: Acyl_transf_3; pfam01757 762051003039 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 762051003040 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 762051003041 active site 762051003042 HIGH motif; other site 762051003043 nucleotide binding site [chemical binding]; other site 762051003044 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 762051003045 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 762051003046 active site 762051003047 KMSKS motif; other site 762051003048 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 762051003049 tRNA binding surface [nucleotide binding]; other site 762051003050 anticodon binding site; other site 762051003051 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 762051003052 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 762051003053 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 762051003054 dimer interface [polypeptide binding]; other site 762051003055 active site 762051003056 CoA binding pocket [chemical binding]; other site 762051003057 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 762051003058 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 762051003059 SCP: SCP-like extracellular protein domain, found in eukaryotes and prokaryotes. This family includes plant pathogenesis-related protein 1 (PR-1), which accumulates after infections with pathogens, and may act as an anti-fungal agent or be involved in...; Region: SCP; cl00133 762051003060 NlpC/P60 family; Region: NLPC_P60; cl17555 762051003061 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 762051003062 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 762051003063 FemAB family; Region: FemAB; pfam02388 762051003064 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 762051003065 PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396 762051003066 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 762051003067 active site 762051003068 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832 762051003069 exopolyphosphatase; Region: exo_poly_only; TIGR03706 762051003070 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 762051003071 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 762051003072 homodimer interface [polypeptide binding]; other site 762051003073 catalytic residues [active] 762051003074 NAD binding site [chemical binding]; other site 762051003075 substrate binding pocket [chemical binding]; other site 762051003076 flexible flap; other site 762051003077 NAD-dependent deacetylase; Provisional; Region: PRK00481 762051003078 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 762051003079 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 762051003080 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 762051003081 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 762051003082 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 762051003083 ABC-ATPase subunit interface; other site 762051003084 dimer interface [polypeptide binding]; other site 762051003085 putative PBP binding regions; other site 762051003086 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 762051003087 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 762051003088 intersubunit interface [polypeptide binding]; other site 762051003089 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 762051003090 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 762051003091 manganese transport protein MntH; Reviewed; Region: PRK00701 762051003092 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 762051003093 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 762051003094 Ligand Binding Site [chemical binding]; other site 762051003095 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 762051003096 dimerization interface [polypeptide binding]; other site 762051003097 putative DNA binding site [nucleotide binding]; other site 762051003098 putative Zn2+ binding site [ion binding]; other site 762051003099 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 762051003100 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 762051003101 S-adenosylmethionine binding site [chemical binding]; other site 762051003102 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 762051003103 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 762051003104 P-loop; other site 762051003105 Magnesium ion binding site [ion binding]; other site 762051003106 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 762051003107 ParB-like nuclease domain; Region: ParB; smart00470 762051003108 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 762051003109 GTP-binding protein YchF; Reviewed; Region: PRK09601 762051003110 YchF GTPase; Region: YchF; cd01900 762051003111 G1 box; other site 762051003112 GTP/Mg2+ binding site [chemical binding]; other site 762051003113 Switch I region; other site 762051003114 G2 box; other site 762051003115 Switch II region; other site 762051003116 G3 box; other site 762051003117 G4 box; other site 762051003118 G5 box; other site 762051003119 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 762051003120 Protein of unknown function (DUF1129); Region: DUF1129; pfam06570 762051003121 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 762051003122 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 762051003123 active site 762051003124 phosphorylation site [posttranslational modification] 762051003125 intermolecular recognition site; other site 762051003126 dimerization interface [polypeptide binding]; other site 762051003127 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 762051003128 DNA binding site [nucleotide binding] 762051003129 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 762051003130 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 762051003131 dimer interface [polypeptide binding]; other site 762051003132 phosphorylation site [posttranslational modification] 762051003133 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762051003134 ATP binding site [chemical binding]; other site 762051003135 Mg2+ binding site [ion binding]; other site 762051003136 G-X-G motif; other site 762051003137 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 762051003138 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 762051003139 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 762051003140 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 762051003141 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 762051003142 active site 762051003143 trimer interface [polypeptide binding]; other site 762051003144 allosteric site; other site 762051003145 active site lid [active] 762051003146 hexamer (dimer of trimers) interface [polypeptide binding]; other site 762051003147 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 762051003148 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 762051003149 active site 762051003150 dimer interface [polypeptide binding]; other site 762051003151 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 762051003152 dimer interface [polypeptide binding]; other site 762051003153 active site 762051003154 Type II/IV secretion system protein; Region: T2SE; pfam00437 762051003155 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 762051003156 Walker A motif; other site 762051003157 ATP binding site [chemical binding]; other site 762051003158 Walker B motif; other site 762051003159 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 762051003160 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 762051003161 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 762051003162 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 762051003163 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 762051003164 Methyltransferase domain; Region: Methyltransf_26; pfam13659 762051003165 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 762051003166 propionate/acetate kinase; Provisional; Region: PRK12379 762051003167 proteins similar to Escherichia coli yceG; Region: yceG_like; cl17666 762051003168 dimerization interface [polypeptide binding]; other site 762051003169 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 762051003170 Sugar transport protein; Region: Sugar_transport; pfam06800 762051003171 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 762051003172 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 762051003173 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 762051003174 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 762051003175 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 762051003176 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 762051003177 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 762051003178 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 762051003179 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762051003180 NADH(P)-binding; Region: NAD_binding_10; pfam13460 762051003181 NAD(P) binding site [chemical binding]; other site 762051003182 active site 762051003183 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 762051003184 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 762051003185 Walker A motif; other site 762051003186 ATP binding site [chemical binding]; other site 762051003187 Walker B motif; other site 762051003188 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3864 762051003189 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 762051003190 metal ion-dependent adhesion site (MIDAS); other site 762051003191 Thiamine-precursor transporter protein (ThiW); Region: ThiW; cl01952 762051003192 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 762051003193 substrate binding site [chemical binding]; other site 762051003194 multimerization interface [polypeptide binding]; other site 762051003195 ATP binding site [chemical binding]; other site 762051003196 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 762051003197 dimer interface [polypeptide binding]; other site 762051003198 substrate binding site [chemical binding]; other site 762051003199 ATP binding site [chemical binding]; other site 762051003200 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 762051003201 thiamine phosphate binding site [chemical binding]; other site 762051003202 active site 762051003203 pyrophosphate binding site [ion binding]; other site 762051003204 Predicted transcriptional regulators [Transcription]; Region: COG1695 762051003205 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 762051003206 Protein of unknown function (DUF1700); Region: DUF1700; pfam08006 762051003207 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 762051003208 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 762051003209 Uncharacterized conserved protein [Function unknown]; Region: COG0398 762051003210 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 762051003211 Predicted membrane protein [Function unknown]; Region: COG2035 762051003212 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 762051003213 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_2; cd09607 762051003214 active site 762051003215 Zn binding site [ion binding]; other site 762051003216 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 762051003217 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 762051003218 Glutamate 5-kinase [Amino acid transport and metabolism]; Region: ProB; COG0263 762051003219 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 762051003220 nucleotide binding site [chemical binding]; other site 762051003221 homotetrameric interface [polypeptide binding]; other site 762051003222 putative phosphate binding site [ion binding]; other site 762051003223 putative allosteric binding site; other site 762051003224 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 762051003225 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 762051003226 putative catalytic cysteine [active] 762051003227 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 762051003228 catalytic core [active] 762051003229 NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650 762051003230 active site 762051003231 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 762051003232 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 762051003233 SEC10/PgrA surface exclusion domain; Region: Surf_Exclu_PgrA; TIGR04320 762051003234 Predicted membrane protein [Function unknown]; Region: COG4640 762051003235 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; cl17626 762051003236 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 762051003237 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 762051003238 Zn2+ binding site [ion binding]; other site 762051003239 Mg2+ binding site [ion binding]; other site 762051003240 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 762051003241 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 762051003242 active site 762051003243 HIGH motif; other site 762051003244 KMSKS motif; other site 762051003245 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 762051003246 tRNA binding surface [nucleotide binding]; other site 762051003247 anticodon binding site; other site 762051003248 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 762051003249 dimer interface [polypeptide binding]; other site 762051003250 putative tRNA-binding site [nucleotide binding]; other site 762051003251 Biotin operon repressor [Transcription]; Region: BirA; COG1654 762051003252 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 762051003253 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 762051003254 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 762051003255 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 762051003256 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK06916 762051003257 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 762051003258 inhibitor-cofactor binding pocket; inhibition site 762051003259 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762051003260 catalytic residue [active] 762051003261 AAA domain; Region: AAA_26; pfam13500 762051003262 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 762051003263 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 762051003264 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 762051003265 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 762051003266 putative phosphoesterase; Region: acc_ester; TIGR03729 762051003267 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 762051003268 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 762051003269 MarR family; Region: MarR_2; pfam12802 762051003270 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 762051003271 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 762051003272 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 762051003273 dimer interface [polypeptide binding]; other site 762051003274 active site 762051003275 CoA binding pocket [chemical binding]; other site 762051003276 acyl carrier protein; Provisional; Region: acpP; PRK00982 762051003277 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 762051003278 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 762051003279 FMN binding site [chemical binding]; other site 762051003280 substrate binding site [chemical binding]; other site 762051003281 putative catalytic residue [active] 762051003282 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 762051003283 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 762051003284 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 762051003285 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 762051003286 NAD(P) binding site [chemical binding]; other site 762051003287 homotetramer interface [polypeptide binding]; other site 762051003288 homodimer interface [polypeptide binding]; other site 762051003289 active site 762051003290 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 762051003291 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 762051003292 dimer interface [polypeptide binding]; other site 762051003293 active site 762051003294 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 762051003295 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 762051003296 carboxyltransferase (CT) interaction site; other site 762051003297 biotinylation site [posttranslational modification]; other site 762051003298 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 762051003299 potential frameshift: common BLAST hit: gi|170016667|ref|YP_001727586.1| biotin carboxylase 762051003300 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 762051003301 ATP-grasp domain; Region: ATP-grasp_4; cl17255 762051003302 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 762051003303 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 762051003304 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 762051003305 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 762051003306 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 762051003307 TspO/MBR family; Region: TspO_MBR; pfam03073 762051003308 Protein of unknown function (DUF3923); Region: DUF3923; pfam13061 762051003309 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762051003310 NAD(P) binding site [chemical binding]; other site 762051003311 ribonuclease HIII; Provisional; Region: PRK00996 762051003312 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 762051003313 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 762051003314 RNA/DNA hybrid binding site [nucleotide binding]; other site 762051003315 active site 762051003316 Colicin V production protein; Region: Colicin_V; pfam02674 762051003317 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 762051003318 MutS domain III; Region: MutS_III; pfam05192 762051003319 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 762051003320 Walker A/P-loop; other site 762051003321 ATP binding site [chemical binding]; other site 762051003322 Q-loop/lid; other site 762051003323 ABC transporter signature motif; other site 762051003324 Walker B; other site 762051003325 D-loop; other site 762051003326 H-loop/switch region; other site 762051003327 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 762051003328 Smr domain; Region: Smr; pfam01713 762051003329 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 762051003330 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 762051003331 DNA binding site [nucleotide binding] 762051003332 catalytic residue [active] 762051003333 H2TH interface [polypeptide binding]; other site 762051003334 putative catalytic residues [active] 762051003335 turnover-facilitating residue; other site 762051003336 intercalation triad [nucleotide binding]; other site 762051003337 8OG recognition residue [nucleotide binding]; other site 762051003338 putative reading head residues; other site 762051003339 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 762051003340 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 762051003341 Protein of unknown function (DUF975); Region: DUF975; cl10504 762051003342 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 762051003343 dephospho-CoA kinase; Region: TIGR00152 762051003344 CoA-binding site [chemical binding]; other site 762051003345 ATP-binding [chemical binding]; other site 762051003346 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 762051003347 primosomal protein DnaI; Reviewed; Region: PRK08939 762051003348 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 762051003349 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 762051003350 Walker A motif; other site 762051003351 ATP binding site [chemical binding]; other site 762051003352 Walker B motif; other site 762051003353 arginine finger; other site 762051003354 YibE/F-like protein; Region: YibE_F; pfam07907 762051003355 YibE/F-like protein; Region: YibE_F; pfam07907 762051003356 Protein of unknown function (DUF2185); Region: DUF2185; cl02019 762051003357 beta-1,6-galactofuranosyltransferase; Provisional; Region: PRK09814 762051003358 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 762051003359 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 762051003360 ligand binding site [chemical binding]; other site 762051003361 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 762051003362 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 762051003363 substrate binding pocket [chemical binding]; other site 762051003364 membrane-bound complex binding site; other site 762051003365 hinge residues; other site 762051003366 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 762051003367 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762051003368 dimer interface [polypeptide binding]; other site 762051003369 conserved gate region; other site 762051003370 putative PBP binding loops; other site 762051003371 ABC-ATPase subunit interface; other site 762051003372 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 762051003373 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 762051003374 Walker A/P-loop; other site 762051003375 ATP binding site [chemical binding]; other site 762051003376 Q-loop/lid; other site 762051003377 ABC transporter signature motif; other site 762051003378 Walker B; other site 762051003379 D-loop; other site 762051003380 H-loop/switch region; other site 762051003381 potential protein location (hypothetical protein) that overlaps protein (glutamine ABC transporter, ATP-binding protein) 762051003382 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 762051003383 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 762051003384 substrate binding pocket [chemical binding]; other site 762051003385 membrane-bound complex binding site; other site 762051003386 hinge residues; other site 762051003387 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 762051003388 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762051003389 dimer interface [polypeptide binding]; other site 762051003390 conserved gate region; other site 762051003391 putative PBP binding loops; other site 762051003392 ABC-ATPase subunit interface; other site 762051003393 Competence protein CoiA-like family; Region: CoiA; cl11541 762051003394 oligoendopeptidase F; Region: pepF; TIGR00181 762051003395 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 762051003396 active site 762051003397 Zn binding site [ion binding]; other site 762051003398 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 762051003399 active site 762051003400 catalytic motif [active] 762051003401 Zn binding site [ion binding]; other site 762051003402 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 762051003403 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_2; cd12172 762051003404 putative ligand binding site [chemical binding]; other site 762051003405 putative NAD binding site [chemical binding]; other site 762051003406 catalytic site [active] 762051003407 Transcriptional regulators [Transcription]; Region: PurR; COG1609 762051003408 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 762051003409 DNA binding site [nucleotide binding] 762051003410 domain linker motif; other site 762051003411 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 762051003412 dimerization interface [polypeptide binding]; other site 762051003413 ligand binding site [chemical binding]; other site 762051003414 sodium binding site [ion binding]; other site 762051003415 L-threonine dehydrogenase; Region: threonine_DH_like; cd08234 762051003416 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 762051003417 putative NAD(P) binding site [chemical binding]; other site 762051003418 catalytic Zn binding site [ion binding]; other site 762051003419 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 762051003420 active site 762051003421 metal binding site [ion binding]; metal-binding site 762051003422 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 762051003423 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 762051003424 nucleotide binding site [chemical binding]; other site 762051003425 Predicted transcriptional regulators [Transcription]; Region: COG1733 762051003426 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 762051003427 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 762051003428 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 762051003429 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 762051003430 dimer interface [polypeptide binding]; other site 762051003431 motif 1; other site 762051003432 active site 762051003433 motif 2; other site 762051003434 motif 3; other site 762051003435 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 762051003436 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 762051003437 putative tRNA-binding site [nucleotide binding]; other site 762051003438 B3/4 domain; Region: B3_4; pfam03483 762051003439 tRNA synthetase B5 domain; Region: B5; smart00874 762051003440 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 762051003441 dimer interface [polypeptide binding]; other site 762051003442 motif 1; other site 762051003443 motif 3; other site 762051003444 motif 2; other site 762051003445 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 762051003446 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 762051003447 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 762051003448 hinge; other site 762051003449 active site 762051003450 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 762051003451 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 762051003452 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 762051003453 S-adenosylmethionine binding site [chemical binding]; other site 762051003454 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 762051003455 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 762051003456 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 762051003457 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 762051003458 Beta-lactamase; Region: Beta-lactamase; pfam00144 762051003459 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 762051003460 DEAD-like helicases superfamily; Region: DEXDc; smart00487 762051003461 ATP binding site [chemical binding]; other site 762051003462 Mg++ binding site [ion binding]; other site 762051003463 motif III; other site 762051003464 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 762051003465 nucleotide binding region [chemical binding]; other site 762051003466 ATP-binding site [chemical binding]; other site 762051003467 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 762051003468 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 762051003469 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 762051003470 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 762051003471 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762051003472 putative substrate translocation pore; other site 762051003473 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 762051003474 MPN+ (JAMM) motif; other site 762051003475 Zinc-binding site [ion binding]; other site 762051003476 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 762051003477 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 762051003478 DNA binding residues [nucleotide binding] 762051003479 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 762051003480 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 762051003481 Preprotein translocase subunit; Region: YajC; cl00806 762051003482 HD domain; Region: HD_3; cl17350 762051003483 potential frameshift: common BLAST hit: gi|170016733|ref|YP_001727652.1| NTP pyrophosphohydrolase including oxidative damage repair 762051003484 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 762051003485 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 762051003486 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 762051003487 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 762051003488 Walker A/P-loop; other site 762051003489 ATP binding site [chemical binding]; other site 762051003490 Q-loop/lid; other site 762051003491 ABC transporter signature motif; other site 762051003492 Walker B; other site 762051003493 D-loop; other site 762051003494 H-loop/switch region; other site 762051003495 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 762051003496 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 762051003497 FtsX-like permease family; Region: FtsX; pfam02687 762051003498 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 762051003499 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 762051003500 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 762051003501 Walker A/P-loop; other site 762051003502 ATP binding site [chemical binding]; other site 762051003503 Q-loop/lid; other site 762051003504 ABC transporter signature motif; other site 762051003505 Walker B; other site 762051003506 D-loop; other site 762051003507 H-loop/switch region; other site 762051003508 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 762051003509 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 762051003510 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 762051003511 Walker A/P-loop; other site 762051003512 ATP binding site [chemical binding]; other site 762051003513 Q-loop/lid; other site 762051003514 ABC transporter signature motif; other site 762051003515 Walker B; other site 762051003516 D-loop; other site 762051003517 H-loop/switch region; other site 762051003518 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 762051003519 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 762051003520 putative ADP-binding pocket [chemical binding]; other site 762051003521 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 762051003522 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 762051003523 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 762051003524 Protein of unknown function (DUF1797); Region: DUF1797; cl11550 762051003525 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 762051003526 Sulfatase; Region: Sulfatase; pfam00884 762051003527 excinuclease ABC subunit B; Provisional; Region: PRK05298 762051003528 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 762051003529 ATP binding site [chemical binding]; other site 762051003530 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 762051003531 nucleotide binding region [chemical binding]; other site 762051003532 ATP-binding site [chemical binding]; other site 762051003533 Ultra-violet resistance protein B; Region: UvrB; pfam12344 762051003534 UvrB/uvrC motif; Region: UVR; pfam02151 762051003535 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 762051003536 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 762051003537 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 762051003538 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 762051003539 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 762051003540 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 762051003541 phosphate binding site [ion binding]; other site 762051003542 putative substrate binding pocket [chemical binding]; other site 762051003543 dimer interface [polypeptide binding]; other site 762051003544 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 762051003545 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 762051003546 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 762051003547 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 762051003548 oligomer interface [polypeptide binding]; other site 762051003549 active site residues [active] 762051003550 D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186 762051003551 D-lactate dehydrogenase; Validated; Region: PRK08605 762051003552 homodimer interface [polypeptide binding]; other site 762051003553 ligand binding site [chemical binding]; other site 762051003554 NAD binding site [chemical binding]; other site 762051003555 catalytic site [active] 762051003556 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 762051003557 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 762051003558 Homeodomain-like domain; Region: HTH_23; cl17451 762051003559 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 762051003560 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 762051003561 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 762051003562 active site 762051003563 motif I; other site 762051003564 motif II; other site 762051003565 GTPase YqeH; Provisional; Region: PRK13796 762051003566 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 762051003567 GTP/Mg2+ binding site [chemical binding]; other site 762051003568 G4 box; other site 762051003569 G5 box; other site 762051003570 G1 box; other site 762051003571 Switch I region; other site 762051003572 G2 box; other site 762051003573 G3 box; other site 762051003574 Switch II region; other site 762051003575 Escherichia coli YhbY is associated with pre-50S ribosomal subunits, which implies a function in ribosome assembly; Region: CRS1_YhbY; smart01103 762051003576 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 762051003577 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 762051003578 active site 762051003579 (T/H)XGH motif; other site 762051003580 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 762051003581 Zn2+ binding site [ion binding]; other site 762051003582 Mg2+ binding site [ion binding]; other site 762051003583 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 762051003584 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 762051003585 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673 762051003586 hypothetical protein; Provisional; Region: PRK13670 762051003587 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 762051003588 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 762051003589 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 762051003590 active site 762051003591 phosphorylation site [posttranslational modification] 762051003592 intermolecular recognition site; other site 762051003593 dimerization interface [polypeptide binding]; other site 762051003594 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 762051003595 DNA binding site [nucleotide binding] 762051003596 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 762051003597 HAMP domain; Region: HAMP; pfam00672 762051003598 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 762051003599 dimer interface [polypeptide binding]; other site 762051003600 phosphorylation site [posttranslational modification] 762051003601 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762051003602 ATP binding site [chemical binding]; other site 762051003603 Mg2+ binding site [ion binding]; other site 762051003604 G-X-G motif; other site 762051003605 Acylphosphatase; Region: Acylphosphatase; pfam00708 762051003606 OxaA-like protein precursor; Provisional; Region: PRK02463 762051003607 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 762051003608 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 762051003609 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 762051003610 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 762051003611 Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314 762051003612 ribonuclease R; Region: RNase_R; TIGR02063 762051003613 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 762051003614 RNB domain; Region: RNB; pfam00773 762051003615 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 762051003616 RNA binding site [nucleotide binding]; other site 762051003617 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 762051003618 SmpB-tmRNA interface; other site 762051003619 phosphodiesterase; Provisional; Region: PRK12704 762051003620 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 762051003621 Zn2+ binding site [ion binding]; other site 762051003622 Mg2+ binding site [ion binding]; other site 762051003623 Bacterial protein of unknown function (DUF948); Region: DUF948; pfam06103 762051003624 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 762051003625 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 762051003626 catalytic site [active] 762051003627 G-X2-G-X-G-K; other site 762051003628 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 762051003629 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 762051003630 active site 762051003631 Predicted RNA binding protein (contains ribosomal protein S1 domain) [Translation, ribosomal structure and biogenesis]; Region: VacB; COG1098 762051003632 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 762051003633 RNA binding site [nucleotide binding]; other site 762051003634 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762051003635 Major Facilitator Superfamily; Region: MFS_1; pfam07690 762051003636 putative substrate translocation pore; other site 762051003637 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 762051003638 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 762051003639 active site 762051003640 motif I; other site 762051003641 motif II; other site 762051003642 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 762051003643 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 762051003644 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 762051003645 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 762051003646 Coenzyme A binding pocket [chemical binding]; other site 762051003647 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 762051003648 Sulfatase; Region: Sulfatase; pfam00884 762051003649 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 762051003650 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 762051003651 DNA binding residues [nucleotide binding] 762051003652 putative dimer interface [polypeptide binding]; other site 762051003653 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 762051003654 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 762051003655 active site 762051003656 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 762051003657 amphipathic channel; other site 762051003658 Asn-Pro-Ala signature motifs; other site 762051003659 fructuronate transporter; Provisional; Region: PRK10034; cl15264 762051003660 GntP family permease; Region: GntP_permease; pfam02447 762051003661 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 762051003662 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 762051003663 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 762051003664 copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698 762051003665 Penicillinase repressor; Region: Pencillinase_R; pfam03965 762051003666 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK03640 762051003667 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 762051003668 acyl-activating enzyme (AAE) consensus motif; other site 762051003669 putative AMP binding site [chemical binding]; other site 762051003670 putative active site [active] 762051003671 putative CoA binding site [chemical binding]; other site 762051003672 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 762051003673 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 762051003674 S-adenosylmethionine binding site [chemical binding]; other site 762051003675 acetylornithine aminotransferase; Provisional; Region: argD; PRK02936 762051003676 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 762051003677 inhibitor-cofactor binding pocket; inhibition site 762051003678 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762051003679 catalytic residue [active] 762051003680 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 762051003681 nucleotide binding site [chemical binding]; other site 762051003682 N-acetyl-L-glutamate binding site [chemical binding]; other site 762051003683 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 762051003684 heterotetramer interface [polypeptide binding]; other site 762051003685 active site pocket [active] 762051003686 cleavage site 762051003687 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 762051003688 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 762051003689 Predicted transcriptional regulators [Transcription]; Region: COG1695 762051003690 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 762051003691 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 762051003692 substrate binding site [chemical binding]; other site 762051003693 Predicted transcriptional regulator [Transcription]; Region: COG2378 762051003694 GTP-binding protein LepA; Provisional; Region: PRK05433 762051003695 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 762051003696 G1 box; other site 762051003697 putative GEF interaction site [polypeptide binding]; other site 762051003698 GTP/Mg2+ binding site [chemical binding]; other site 762051003699 Switch I region; other site 762051003700 G2 box; other site 762051003701 G3 box; other site 762051003702 Switch II region; other site 762051003703 G4 box; other site 762051003704 G5 box; other site 762051003705 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 762051003706 Elongation factor G C-terminus. This domain includes the carboxyl terminal regions of elongation factors (EFs) bacterial EF-G, eukaryotic and archeal EF-2 and eukaryotic mitochondrial mtEFG1s and mtEFG2s. This group also includes proteins similar to the...; Region: Elongation_Factor_C; cl02785 762051003707 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 762051003708 Glycosyl hydrolases family 32 N-terminal domain; Region: Glyco_hydro_32N; pfam00251 762051003709 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 762051003710 substrate binding [chemical binding]; other site 762051003711 active site 762051003712 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 762051003713 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 762051003714 non-specific DNA binding site [nucleotide binding]; other site 762051003715 salt bridge; other site 762051003716 sequence-specific DNA binding site [nucleotide binding]; other site 762051003717 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762051003718 putative substrate translocation pore; other site 762051003719 H+ Antiporter protein; Region: 2A0121; TIGR00900 762051003720 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 762051003721 dimerization interface [polypeptide binding]; other site 762051003722 putative DNA binding site [nucleotide binding]; other site 762051003723 putative Zn2+ binding site [ion binding]; other site 762051003724 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762051003725 Major Facilitator Superfamily; Region: MFS_1; pfam07690 762051003726 putative substrate translocation pore; other site 762051003727 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 762051003728 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 762051003729 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 762051003730 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 762051003731 Predicted transcriptional regulators [Transcription]; Region: COG1695 762051003732 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 762051003733 OsmC-like protein; Region: OsmC; cl00767 762051003734 Zinc-dependent metalloprotease, MMP_like subfamily. This group contains matrix metalloproteinases (MMPs), serralysins, and the astacin_like family of proteases; Region: ZnMc_MMP_like; cd04268 762051003735 active site 762051003736 D-ribose pyranase; Provisional; Region: PRK11797 762051003737 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 762051003738 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 762051003739 Walker A/P-loop; other site 762051003740 ATP binding site [chemical binding]; other site 762051003741 Q-loop/lid; other site 762051003742 ABC transporter signature motif; other site 762051003743 Walker B; other site 762051003744 D-loop; other site 762051003745 H-loop/switch region; other site 762051003746 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 762051003747 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 762051003748 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 762051003749 TM-ABC transporter signature motif; other site 762051003750 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 762051003751 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 762051003752 ligand binding site [chemical binding]; other site 762051003753 dimerization interface [polypeptide binding]; other site 762051003754 D-lactate dehydrogenase; Provisional; Region: PRK11183 762051003755 FAD binding domain; Region: FAD_binding_4; pfam01565 762051003756 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 762051003757 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 762051003758 TrkA-N domain; Region: TrkA_N; pfam02254 762051003759 TrkA-C domain; Region: TrkA_C; pfam02080 762051003760 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 762051003761 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 762051003762 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 762051003763 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 762051003764 Predicted transcriptional regulator [Transcription]; Region: COG1959 762051003765 Transcriptional regulator; Region: Rrf2; pfam02082 762051003766 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762051003767 NADH(P)-binding; Region: NAD_binding_10; pfam13460 762051003768 NAD(P) binding site [chemical binding]; other site 762051003769 active site 762051003770 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762051003771 Major Facilitator Superfamily; Region: MFS_1; pfam07690 762051003772 putative substrate translocation pore; other site 762051003773 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762051003774 Major Facilitator Superfamily; Region: MFS_1; pfam07690 762051003775 putative substrate translocation pore; other site 762051003776 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762051003777 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 762051003778 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 762051003779 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762051003780 Major Facilitator Superfamily; Region: MFS_1; pfam07690 762051003781 putative substrate translocation pore; other site 762051003782 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762051003783 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 762051003784 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 762051003785 Walker A/P-loop; other site 762051003786 ATP binding site [chemical binding]; other site 762051003787 Q-loop/lid; other site 762051003788 ABC transporter signature motif; other site 762051003789 Walker B; other site 762051003790 D-loop; other site 762051003791 H-loop/switch region; other site 762051003792 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 762051003793 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 762051003794 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 762051003795 TM-ABC transporter signature motif; other site 762051003796 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 762051003797 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 762051003798 TM-ABC transporter signature motif; other site 762051003799 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 762051003800 dimerization interface [polypeptide binding]; other site 762051003801 putative DNA binding site [nucleotide binding]; other site 762051003802 putative Zn2+ binding site [ion binding]; other site 762051003803 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762051003804 Major Facilitator Superfamily; Region: MFS_1; pfam07690 762051003805 putative substrate translocation pore; other site 762051003806 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 762051003807 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 762051003808 Predicted transcriptional regulators [Transcription]; Region: COG1733 762051003809 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 762051003810 potential frameshift: common BLAST hit: gi|81428617|ref|YP_395617.1| zinc-containing alcohol dehydrogenase (oxidoreductase) 762051003811 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 762051003812 putative NAD(P) binding site [chemical binding]; other site 762051003813 dimer interface [polypeptide binding]; other site 762051003814 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 762051003815 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 762051003816 tetramer (dimer of dimers) interface [polypeptide binding]; other site 762051003817 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 762051003818 NAD binding site [chemical binding]; other site 762051003819 dimer interface [polypeptide binding]; other site 762051003820 substrate binding site [chemical binding]; other site 762051003821 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 762051003822 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 762051003823 Walker A/P-loop; other site 762051003824 ATP binding site [chemical binding]; other site 762051003825 Q-loop/lid; other site 762051003826 ABC transporter signature motif; other site 762051003827 Walker B; other site 762051003828 D-loop; other site 762051003829 H-loop/switch region; other site 762051003830 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 762051003831 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 762051003832 TM-ABC transporter signature motif; other site 762051003833 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 762051003834 zinc binding site [ion binding]; other site 762051003835 putative ligand binding site [chemical binding]; other site 762051003836 Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300 762051003837 Cadmium resistance transporter; Region: Cad; pfam03596 762051003838 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 762051003839 dimerization interface [polypeptide binding]; other site 762051003840 putative DNA binding site [nucleotide binding]; other site 762051003841 putative Zn2+ binding site [ion binding]; other site 762051003842 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 762051003843 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 762051003844 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 762051003845 putative active site [active] 762051003846 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 762051003847 This family represents an uncharacterized glycosyl hydrolase family 31 (GH31) enzyme found in bacteria and eukaryotes that is related to the XylS xylosidase of Sulfolobus solfataricus. Alpha-xylosidases catalyze the release of an alpha-xylose residue...; Region: GH31_xylosidase_XylS-like; cd06595 762051003848 putative active site [active] 762051003849 putative catalytic site [active] 762051003850 Major Facilitator Superfamily; Region: MFS_1; pfam07690 762051003851 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762051003852 putative substrate translocation pore; other site 762051003853 Amb_all domain; Region: Amb_all; smart00656 762051003854 amino acid transporter; Region: 2A0306; TIGR00909 762051003855 bacteriocin secretion accessory protein; Region: bacteriocin_acc; TIGR01000 762051003856 HlyD family secretion protein; Region: HlyD_3; pfam13437 762051003857 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418 762051003858 ABC-type bacteriocin transporter; Region: bacteriocin_ABC; TIGR01193 762051003859 putative active site [active] 762051003860 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 762051003861 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 762051003862 Walker A/P-loop; other site 762051003863 ATP binding site [chemical binding]; other site 762051003864 Q-loop/lid; other site 762051003865 ABC transporter signature motif; other site 762051003866 Walker B; other site 762051003867 D-loop; other site 762051003868 H-loop/switch region; other site 762051003869 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 762051003870 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 762051003871 active site 762051003872 phosphorylation site [posttranslational modification] 762051003873 intermolecular recognition site; other site 762051003874 dimerization interface [polypeptide binding]; other site 762051003875 LytTr DNA-binding domain; Region: LytTR; pfam04397 762051003876 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 762051003877 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 762051003878 CrcB-like protein; Region: CRCB; cl09114 762051003879 CrcB-like protein; Region: CRCB; pfam02537 762051003880 EDD domain protein, DegV family; Region: DegV; TIGR00762 762051003881 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 762051003882 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 762051003883 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 762051003884 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 762051003885 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 762051003886 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 762051003887 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 762051003888 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 762051003889 substrate binding pocket [chemical binding]; other site 762051003890 membrane-bound complex binding site; other site 762051003891 hinge residues; other site 762051003892 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762051003893 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 762051003894 dimer interface [polypeptide binding]; other site 762051003895 conserved gate region; other site 762051003896 putative PBP binding loops; other site 762051003897 ABC-ATPase subunit interface; other site 762051003898 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762051003899 dimer interface [polypeptide binding]; other site 762051003900 conserved gate region; other site 762051003901 putative PBP binding loops; other site 762051003902 ABC-ATPase subunit interface; other site 762051003903 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 762051003904 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 762051003905 Walker A/P-loop; other site 762051003906 ATP binding site [chemical binding]; other site 762051003907 Q-loop/lid; other site 762051003908 ABC transporter signature motif; other site 762051003909 Walker B; other site 762051003910 D-loop; other site 762051003911 H-loop/switch region; other site 762051003912 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 762051003913 Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124 762051003914 active site 762051003915 zinc binding site [ion binding]; other site 762051003916 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 762051003917 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 762051003918 G1 box; other site 762051003919 putative GEF interaction site [polypeptide binding]; other site 762051003920 GTP/Mg2+ binding site [chemical binding]; other site 762051003921 Switch I region; other site 762051003922 G2 box; other site 762051003923 G3 box; other site 762051003924 Switch II region; other site 762051003925 G4 box; other site 762051003926 G5 box; other site 762051003927 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 762051003928 uracil transporter; Provisional; Region: PRK10720 762051003929 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 762051003930 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 762051003931 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 762051003932 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 762051003933 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 762051003934 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 762051003935 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 762051003936 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 762051003937 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 762051003938 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 762051003939 beta subunit interaction interface [polypeptide binding]; other site 762051003940 Walker A motif; other site 762051003941 ATP binding site [chemical binding]; other site 762051003942 Walker B motif; other site 762051003943 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 762051003944 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 762051003945 core domain interface [polypeptide binding]; other site 762051003946 delta subunit interface [polypeptide binding]; other site 762051003947 epsilon subunit interface [polypeptide binding]; other site 762051003948 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 762051003949 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 762051003950 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 762051003951 alpha subunit interaction interface [polypeptide binding]; other site 762051003952 Walker A motif; other site 762051003953 ATP binding site [chemical binding]; other site 762051003954 Walker B motif; other site 762051003955 inhibitor binding site; inhibition site 762051003956 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 762051003957 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 762051003958 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 762051003959 gamma subunit interface [polypeptide binding]; other site 762051003960 epsilon subunit interface [polypeptide binding]; other site 762051003961 LBP interface [polypeptide binding]; other site 762051003962 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 762051003963 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 762051003964 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 762051003965 Walker A/P-loop; other site 762051003966 ATP binding site [chemical binding]; other site 762051003967 Q-loop/lid; other site 762051003968 ABC transporter signature motif; other site 762051003969 Walker B; other site 762051003970 D-loop; other site 762051003971 H-loop/switch region; other site 762051003972 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 762051003973 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762051003974 dimer interface [polypeptide binding]; other site 762051003975 conserved gate region; other site 762051003976 putative PBP binding loops; other site 762051003977 ABC-ATPase subunit interface; other site 762051003978 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 762051003979 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762051003980 dimer interface [polypeptide binding]; other site 762051003981 conserved gate region; other site 762051003982 ABC-ATPase subunit interface; other site 762051003983 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 762051003984 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 762051003985 active site 762051003986 metal binding site [ion binding]; metal-binding site 762051003987 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 762051003988 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 762051003989 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 762051003990 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 762051003991 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 762051003992 putative active site [active] 762051003993 putative FMN binding site [chemical binding]; other site 762051003994 putative substrate binding site [chemical binding]; other site 762051003995 putative catalytic residue [active] 762051003996 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 762051003997 Part of AAA domain; Region: AAA_19; pfam13245 762051003998 Family description; Region: UvrD_C_2; pfam13538 762051003999 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 762051004000 AAA domain; Region: AAA_18; pfam13238 762051004001 active site 762051004002 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762051004003 Major Facilitator Superfamily; Region: MFS_1; pfam07690 762051004004 putative substrate translocation pore; other site 762051004005 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762051004006 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 762051004007 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 762051004008 accessory Sec system glycosyltransferase GtfB; Region: TIGR02919 762051004009 Phosphoglycerate kinase; Region: PGK; pfam00162 762051004010 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 762051004011 substrate binding site [chemical binding]; other site 762051004012 hinge regions; other site 762051004013 ADP binding site [chemical binding]; other site 762051004014 catalytic site [active] 762051004015 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 762051004016 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 762051004017 active site 762051004018 HIGH motif; other site 762051004019 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 762051004020 KMSKS motif; other site 762051004021 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 762051004022 tRNA binding surface [nucleotide binding]; other site 762051004023 anticodon binding site; other site 762051004024 seryl-tRNA synthetase; Provisional; Region: PRK05431 762051004025 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 762051004026 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 762051004027 dimer interface [polypeptide binding]; other site 762051004028 active site 762051004029 motif 1; other site 762051004030 motif 2; other site 762051004031 motif 3; other site 762051004032 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 762051004033 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 762051004034 peptide chain release factor 2; Validated; Region: prfB; PRK00578 762051004035 This domain is found in peptide chain release factors; Region: PCRF; smart00937 762051004036 RF-1 domain; Region: RF-1; pfam00472 762051004037 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 762051004038 Clp amino terminal domain; Region: Clp_N; pfam02861 762051004039 Clp amino terminal domain; Region: Clp_N; pfam02861 762051004040 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 762051004041 Walker A motif; other site 762051004042 ATP binding site [chemical binding]; other site 762051004043 Walker B motif; other site 762051004044 arginine finger; other site 762051004045 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 762051004046 Walker A motif; other site 762051004047 ATP binding site [chemical binding]; other site 762051004048 Walker B motif; other site 762051004049 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 762051004050 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 762051004051 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 762051004052 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 762051004053 S17 interaction site [polypeptide binding]; other site 762051004054 S8 interaction site; other site 762051004055 16S rRNA interaction site [nucleotide binding]; other site 762051004056 streptomycin interaction site [chemical binding]; other site 762051004057 23S rRNA interaction site [nucleotide binding]; other site 762051004058 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 762051004059 30S ribosomal protein S7; Validated; Region: PRK05302 762051004060 elongation factor G; Reviewed; Region: PRK12739 762051004061 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 762051004062 G1 box; other site 762051004063 putative GEF interaction site [polypeptide binding]; other site 762051004064 GTP/Mg2+ binding site [chemical binding]; other site 762051004065 Switch I region; other site 762051004066 G2 box; other site 762051004067 G3 box; other site 762051004068 Switch II region; other site 762051004069 G4 box; other site 762051004070 G5 box; other site 762051004071 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 762051004072 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 762051004073 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 762051004074 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 762051004075 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762051004076 putative substrate translocation pore; other site 762051004077 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 762051004078 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 762051004079 Walker A/P-loop; other site 762051004080 ATP binding site [chemical binding]; other site 762051004081 Q-loop/lid; other site 762051004082 ABC transporter signature motif; other site 762051004083 Walker B; other site 762051004084 D-loop; other site 762051004085 H-loop/switch region; other site 762051004086 TOBE domain; Region: TOBE_2; pfam08402 762051004087 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 762051004088 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762051004089 dimer interface [polypeptide binding]; other site 762051004090 conserved gate region; other site 762051004091 putative PBP binding loops; other site 762051004092 ABC-ATPase subunit interface; other site 762051004093 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 762051004094 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762051004095 dimer interface [polypeptide binding]; other site 762051004096 conserved gate region; other site 762051004097 ABC-ATPase subunit interface; other site 762051004098 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 762051004099 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 762051004100 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 762051004101 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 762051004102 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 762051004103 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 762051004104 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 762051004105 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 762051004106 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 762051004107 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 762051004108 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 762051004109 putative translocon binding site; other site 762051004110 protein-rRNA interface [nucleotide binding]; other site 762051004111 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 762051004112 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 762051004113 G-X-X-G motif; other site 762051004114 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 762051004115 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 762051004116 23S rRNA interface [nucleotide binding]; other site 762051004117 5S rRNA interface [nucleotide binding]; other site 762051004118 putative antibiotic binding site [chemical binding]; other site 762051004119 L25 interface [polypeptide binding]; other site 762051004120 L27 interface [polypeptide binding]; other site 762051004121 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 762051004122 putative translocon interaction site; other site 762051004123 23S rRNA interface [nucleotide binding]; other site 762051004124 signal recognition particle (SRP54) interaction site; other site 762051004125 L23 interface [polypeptide binding]; other site 762051004126 trigger factor interaction site; other site 762051004127 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 762051004128 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 762051004129 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 762051004130 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 762051004131 RNA binding site [nucleotide binding]; other site 762051004132 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 762051004133 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 762051004134 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 762051004135 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 762051004136 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 762051004137 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 762051004138 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 762051004139 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 762051004140 5S rRNA interface [nucleotide binding]; other site 762051004141 L27 interface [polypeptide binding]; other site 762051004142 23S rRNA interface [nucleotide binding]; other site 762051004143 L5 interface [polypeptide binding]; other site 762051004144 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 762051004145 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 762051004146 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 762051004147 50S ribosomal protein L30; Reviewed; Region: rpmD; PRK05611 762051004148 23S rRNA binding site - archaea [nucleotide binding]; other site 762051004149 23S rRNA binding site - prokaryotes [nucleotide binding]; other site 762051004150 5S rRNA binding site - archaea; other site 762051004151 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 762051004152 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 762051004153 SecY translocase; Region: SecY; pfam00344 762051004154 adenylate kinase; Reviewed; Region: adk; PRK00279 762051004155 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 762051004156 AMP-binding site [chemical binding]; other site 762051004157 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 762051004158 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 762051004159 rRNA binding site [nucleotide binding]; other site 762051004160 predicted 30S ribosome binding site; other site 762051004161 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 762051004162 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 762051004163 30S ribosomal protein S13; Region: bact_S13; TIGR03631 762051004164 30S ribosomal protein S11; Validated; Region: PRK05309 762051004165 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 762051004166 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 762051004167 alphaNTD - beta interaction site [polypeptide binding]; other site 762051004168 alphaNTD homodimer interface [polypeptide binding]; other site 762051004169 alphaNTD - beta' interaction site [polypeptide binding]; other site 762051004170 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 762051004171 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 762051004172 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 762051004173 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 762051004174 substrate binding pocket [chemical binding]; other site 762051004175 chain length determination region; other site 762051004176 substrate-Mg2+ binding site; other site 762051004177 catalytic residues [active] 762051004178 aspartate-rich region 1; other site 762051004179 active site lid residues [active] 762051004180 aspartate-rich region 2; other site 762051004181 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 762051004182 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 762051004183 DoxX; Region: DoxX; pfam07681 762051004184 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635 762051004185 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 762051004186 Walker A/P-loop; other site 762051004187 ATP binding site [chemical binding]; other site 762051004188 Q-loop/lid; other site 762051004189 ABC transporter signature motif; other site 762051004190 Walker B; other site 762051004191 D-loop; other site 762051004192 H-loop/switch region; other site 762051004193 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634 762051004194 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 762051004195 Walker A/P-loop; other site 762051004196 ATP binding site [chemical binding]; other site 762051004197 Q-loop/lid; other site 762051004198 ABC transporter signature motif; other site 762051004199 Walker B; other site 762051004200 D-loop; other site 762051004201 H-loop/switch region; other site 762051004202 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 762051004203 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 762051004204 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 762051004205 dimerization interface 3.5A [polypeptide binding]; other site 762051004206 active site 762051004207 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 762051004208 23S rRNA interface [nucleotide binding]; other site 762051004209 L3 interface [polypeptide binding]; other site 762051004210 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 762051004211 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 762051004212 DNA methylase; Region: N6_N4_Mtase; pfam01555 762051004213 DNA methylase; Region: N6_N4_Mtase; cl17433 762051004214 type III restriction-modification system StyLTI enzyme res; Provisional; Region: PRK15483 762051004215 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 762051004216 DEAD-like helicases superfamily; Region: DEXDc; smart00487 762051004217 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 762051004218 ATP binding site [chemical binding]; other site 762051004219 putative Mg++ binding site [ion binding]; other site 762051004220 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 762051004221 nucleotide binding region [chemical binding]; other site 762051004222 ATP-binding site [chemical binding]; other site 762051004223 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762051004224 Major Facilitator Superfamily; Region: MFS_1; pfam07690 762051004225 putative substrate translocation pore; other site 762051004226 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762051004227 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 762051004228 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 762051004229 HflX GTPase family; Region: HflX; cd01878 762051004230 G1 box; other site 762051004231 GTP/Mg2+ binding site [chemical binding]; other site 762051004232 Switch I region; other site 762051004233 G2 box; other site 762051004234 G3 box; other site 762051004235 Switch II region; other site 762051004236 G4 box; other site 762051004237 G5 box; other site 762051004238 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 762051004239 catalytic core [active] 762051004240 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 762051004241 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 762051004242 Domain of unknown function DUF21; Region: DUF21; pfam01595 762051004243 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 762051004244 Transporter associated domain; Region: CorC_HlyC; smart01091 762051004245 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 762051004246 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07306 762051004247 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 762051004248 Class I ribonucleotide reductase; Region: RNR_I; cd01679 762051004249 active site 762051004250 dimer interface [polypeptide binding]; other site 762051004251 catalytic residues [active] 762051004252 effector binding site; other site 762051004253 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 762051004254 NrdI Flavodoxin like; Region: Flavodoxin_NdrI; cl17293 762051004255 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 762051004256 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 762051004257 dimer interface [polypeptide binding]; other site 762051004258 putative radical transfer pathway; other site 762051004259 diiron center [ion binding]; other site 762051004260 tyrosyl radical; other site 762051004261 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 762051004262 active site 762051004263 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 762051004264 catalytic core [active] 762051004265 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 762051004266 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 762051004267 DNA-binding site [nucleotide binding]; DNA binding site 762051004268 RNA-binding motif; other site 762051004269 Enterocin A Immunity; Region: EntA_Immun; pfam08951 762051004270 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 762051004271 triosephosphate isomerase; Provisional; Region: PRK14565 762051004272 substrate binding site [chemical binding]; other site 762051004273 dimer interface [polypeptide binding]; other site 762051004274 catalytic triad [active] 762051004275 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 762051004276 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 762051004277 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 762051004278 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 762051004279 RPB1 interaction site [polypeptide binding]; other site 762051004280 RPB10 interaction site [polypeptide binding]; other site 762051004281 RPB11 interaction site [polypeptide binding]; other site 762051004282 RPB3 interaction site [polypeptide binding]; other site 762051004283 RPB12 interaction site [polypeptide binding]; other site 762051004284 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 762051004285 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 762051004286 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 762051004287 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 762051004288 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 762051004289 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 762051004290 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 762051004291 DNA binding site [nucleotide binding] 762051004292 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 762051004293 Ribonuclease III family protein [Replication, recombination, and repair]; Region: COG1939 762051004294 active site 762051004295 metal binding site [ion binding]; metal-binding site 762051004296 dimerization interface [polypeptide binding]; other site 762051004297 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 762051004298 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 762051004299 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 762051004300 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 762051004301 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 762051004302 enolase; Provisional; Region: eno; PRK00077 762051004303 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 762051004304 dimer interface [polypeptide binding]; other site 762051004305 metal binding site [ion binding]; metal-binding site 762051004306 substrate binding pocket [chemical binding]; other site 762051004307 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 762051004308 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 762051004309 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 762051004310 Zn2+ binding site [ion binding]; other site 762051004311 Mg2+ binding site [ion binding]; other site 762051004312 polyphosphate kinase; Provisional; Region: PRK05443 762051004313 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 762051004314 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 762051004315 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 762051004316 putative domain interface [polypeptide binding]; other site 762051004317 putative active site [active] 762051004318 catalytic site [active] 762051004319 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 762051004320 putative domain interface [polypeptide binding]; other site 762051004321 putative active site [active] 762051004322 catalytic site [active] 762051004323 exopolyphosphatase; Region: exo_poly_only; TIGR03706 762051004324 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 762051004325 Uncharacterized conserved protein [Function unknown]; Region: COG1739 762051004326 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 762051004327 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 762051004328 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 762051004329 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 762051004330 ATP binding site [chemical binding]; other site 762051004331 putative Mg++ binding site [ion binding]; other site 762051004332 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 762051004333 nucleotide binding region [chemical binding]; other site 762051004334 ATP-binding site [chemical binding]; other site 762051004335 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 762051004336 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 762051004337 active site 762051004338 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 762051004339 30S subunit binding site; other site 762051004340 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 762051004341 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762051004342 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 762051004343 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 762051004344 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 762051004345 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 762051004346 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 762051004347 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 762051004348 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 762051004349 putative homodimer interface [polypeptide binding]; other site 762051004350 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 762051004351 heterodimer interface [polypeptide binding]; other site 762051004352 homodimer interface [polypeptide binding]; other site 762051004353 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 762051004354 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 762051004355 23S rRNA interface [nucleotide binding]; other site 762051004356 L7/L12 interface [polypeptide binding]; other site 762051004357 putative thiostrepton binding site; other site 762051004358 L25 interface [polypeptide binding]; other site 762051004359 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 762051004360 mRNA/rRNA interface [nucleotide binding]; other site 762051004361 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 762051004362 23S rRNA interface [nucleotide binding]; other site 762051004363 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 762051004364 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 762051004365 peripheral dimer interface [polypeptide binding]; other site 762051004366 core dimer interface [polypeptide binding]; other site 762051004367 L10 interface [polypeptide binding]; other site 762051004368 L11 interface [polypeptide binding]; other site 762051004369 putative EF-Tu interaction site [polypeptide binding]; other site 762051004370 putative EF-G interaction site [polypeptide binding]; other site 762051004371 Methyltransferase domain; Region: Methyltransf_31; pfam13847 762051004372 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 762051004373 S-adenosylmethionine binding site [chemical binding]; other site 762051004374 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 762051004375 nucleoside/Zn binding site; other site 762051004376 dimer interface [polypeptide binding]; other site 762051004377 catalytic motif [active] 762051004378 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 762051004379 Zn2+ binding site [ion binding]; other site 762051004380 Mg2+ binding site [ion binding]; other site 762051004381 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 762051004382 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 762051004383 Walker A motif; other site 762051004384 ATP binding site [chemical binding]; other site 762051004385 Walker B motif; other site 762051004386 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 762051004387 recombination protein RecR; Reviewed; Region: recR; PRK00076 762051004388 RecR protein; Region: RecR; pfam02132 762051004389 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 762051004390 putative active site [active] 762051004391 putative metal-binding site [ion binding]; other site 762051004392 tetramer interface [polypeptide binding]; other site 762051004393 Protein of unknown function (DUF2508); Region: DUF2508; pfam10704 762051004394 thymidylate kinase; Validated; Region: tmk; PRK00698 762051004395 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 762051004396 TMP-binding site; other site 762051004397 ATP-binding site [chemical binding]; other site 762051004398 Protein of unknown function (DUF970); Region: DUF970; cl17525 762051004399 DNA polymerase III subunit delta'; Validated; Region: PRK08058 762051004400 DNA polymerase III subunit delta'; Validated; Region: PRK08485 762051004401 Predicted methyltransferases [General function prediction only]; Region: COG0313 762051004402 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 762051004403 putative SAM binding site [chemical binding]; other site 762051004404 putative homodimer interface [polypeptide binding]; other site 762051004405 Acyl-ACP thioesterase [Lipid metabolism]; Region: FatA; COG3884 762051004406 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 762051004407 active site 762051004408 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 762051004409 active site 2 [active] 762051004410 active site 1 [active] 762051004411 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 762051004412 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 762051004413 NAD binding site [chemical binding]; other site 762051004414 homodimer interface [polypeptide binding]; other site 762051004415 active site 762051004416 substrate binding site [chemical binding]; other site 762051004417 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 762051004418 NADH(P)-binding; Region: NAD_binding_10; pfam13460 762051004419 NAD binding site [chemical binding]; other site 762051004420 substrate binding site [chemical binding]; other site 762051004421 putative active site [active] 762051004422 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 762051004423 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 762051004424 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 762051004425 Substrate-binding site [chemical binding]; other site 762051004426 Substrate specificity [chemical binding]; other site 762051004427 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 762051004428 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 762051004429 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 762051004430 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 762051004431 Uncharacterized bacterial muramidase containing a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis...; Region: GH25_muramidase_2; cd06419 762051004432 active site 762051004433 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 762051004434 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 762051004435 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 762051004436 DEAD-like helicases superfamily; Region: DEXDc; smart00487 762051004437 ATP binding site [chemical binding]; other site 762051004438 putative Mg++ binding site [ion binding]; other site 762051004439 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 762051004440 nucleotide binding region [chemical binding]; other site 762051004441 ATP-binding site [chemical binding]; other site 762051004442 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 762051004443 non-specific DNA binding site [nucleotide binding]; other site 762051004444 salt bridge; other site 762051004445 sequence-specific DNA binding site [nucleotide binding]; other site 762051004446 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 762051004447 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 762051004448 Walker A/P-loop; other site 762051004449 ATP binding site [chemical binding]; other site 762051004450 Q-loop/lid; other site 762051004451 ABC transporter signature motif; other site 762051004452 Walker B; other site 762051004453 D-loop; other site 762051004454 H-loop/switch region; other site 762051004455 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 762051004456 FeS assembly protein SufD; Region: sufD; TIGR01981 762051004457 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 762051004458 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 762051004459 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 762051004460 catalytic residue [active] 762051004461 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 762051004462 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 762051004463 trimerization site [polypeptide binding]; other site 762051004464 active site 762051004465 FeS assembly protein SufB; Region: sufB; TIGR01980 762051004466 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 762051004467 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 762051004468 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 762051004469 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 762051004470 active site 762051004471 catalytic residues [active] 762051004472 metal binding site [ion binding]; metal-binding site 762051004473 potential frameshift: common BLAST hit: gi|116619103|ref|YP_819474.1| 3-isopropylmalate dehydrogenase 762051004474 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 762051004475 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 762051004476 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 762051004477 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 762051004478 substrate binding site [chemical binding]; other site 762051004479 ligand binding site [chemical binding]; other site 762051004480 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 762051004481 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 762051004482 substrate binding site [chemical binding]; other site 762051004483 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 762051004484 High-affinity nickel-transport protein; Region: NicO; cl00964 762051004485 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 762051004486 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 762051004487 active site 762051004488 phosphorylation site [posttranslational modification] 762051004489 intermolecular recognition site; other site 762051004490 dimerization interface [polypeptide binding]; other site 762051004491 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 762051004492 DNA binding site [nucleotide binding] 762051004493 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 762051004494 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 762051004495 dimer interface [polypeptide binding]; other site 762051004496 phosphorylation site [posttranslational modification] 762051004497 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762051004498 ATP binding site [chemical binding]; other site 762051004499 Mg2+ binding site [ion binding]; other site 762051004500 G-X-G motif; other site 762051004501 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 762051004502 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 762051004503 catalytic residues [active] 762051004504 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 762051004505 conserved cys residue [active] 762051004506 cystathionine gamma-synthase; Reviewed; Region: PRK08247 762051004507 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 762051004508 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 762051004509 catalytic residue [active] 762051004510 cystathionine beta-lyase; Provisional; Region: PRK08064 762051004511 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 762051004512 homodimer interface [polypeptide binding]; other site 762051004513 substrate-cofactor binding pocket; other site 762051004514 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762051004515 catalytic residue [active] 762051004516 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 762051004517 substrate binding site [chemical binding]; other site 762051004518 zinc-binding site [ion binding]; other site 762051004519 S-ribosylhomocysteinase; Provisional; Region: PRK02260 762051004520 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 762051004521 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 762051004522 homodimer interface [polypeptide binding]; other site 762051004523 substrate-cofactor binding pocket; other site 762051004524 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762051004525 catalytic residue [active] 762051004526 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 762051004527 substrate binding site [chemical binding]; other site 762051004528 THF binding site; other site 762051004529 zinc-binding site [ion binding]; other site 762051004530 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 762051004531 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 762051004532 peptide binding site [polypeptide binding]; other site 762051004533 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 762051004534 Peptidase C26; Region: Peptidase_C26; pfam07722 762051004535 catalytic triad [active] 762051004536 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 762051004537 Transcriptional regulators [Transcription]; Region: PurR; COG1609 762051004538 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 762051004539 DNA binding site [nucleotide binding] 762051004540 domain linker motif; other site 762051004541 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 762051004542 dimerization interface [polypeptide binding]; other site 762051004543 ligand binding site [chemical binding]; other site 762051004544 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762051004545 Major Facilitator Superfamily; Region: MFS_1; pfam07690 762051004546 putative substrate translocation pore; other site 762051004547 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 762051004548 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 762051004549 Ca binding site [ion binding]; other site 762051004550 active site 762051004551 catalytic site [active] 762051004552 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 762051004553 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 762051004554 catalytic triad [active] 762051004555 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 762051004556 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 762051004557 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 762051004558 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 762051004559 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 762051004560 NlpC/P60 family; Region: NLPC_P60; cl17555 762051004561 thymidine kinase; Provisional; Region: PRK04296 762051004562 peptide chain release factor 1; Validated; Region: prfA; PRK00591 762051004563 This domain is found in peptide chain release factors; Region: PCRF; smart00937 762051004564 RF-1 domain; Region: RF-1; pfam00472 762051004565 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 762051004566 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 762051004567 S-adenosylmethionine binding site [chemical binding]; other site 762051004568 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 762051004569 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 762051004570 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 762051004571 dimerization domain swap beta strand [polypeptide binding]; other site 762051004572 regulatory protein interface [polypeptide binding]; other site 762051004573 active site 762051004574 regulatory phosphorylation site [posttranslational modification]; other site 762051004575 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 762051004576 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 762051004577 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 762051004578 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 762051004579 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 762051004580 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 762051004581 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 762051004582 DNA binding residues [nucleotide binding] 762051004583 Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791 762051004584 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 762051004585 Glycoprotease family; Region: Peptidase_M22; pfam00814 762051004586 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 762051004587 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 762051004588 Coenzyme A binding pocket [chemical binding]; other site 762051004589 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 762051004590 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 762051004591 Coenzyme A binding pocket [chemical binding]; other site 762051004592 UGMP family protein; Validated; Region: PRK09604 762051004593 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 762051004594 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 762051004595 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 762051004596 CoA binding domain; Region: CoA_binding; pfam02629 762051004597 Peptidoglycan interpeptide bridge formation enzyme [Cell wall/membrane/envelope biogenesis]; Region: COG2348 762051004598 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 762051004599 Predicted membrane protein [Function unknown]; Region: COG2246 762051004600 GtrA-like protein; Region: GtrA; pfam04138 762051004601 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 762051004602 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 762051004603 active site 762051004604 motif I; other site 762051004605 motif II; other site 762051004606 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 762051004607 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 762051004608 dimer interface [polypeptide binding]; other site 762051004609 FMN binding site [chemical binding]; other site 762051004610 NADPH bind site [chemical binding]; other site 762051004611 Domain of unknown function (DUF955); Region: DUF955; cl01076 762051004612 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 762051004613 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 762051004614 non-specific DNA binding site [nucleotide binding]; other site 762051004615 salt bridge; other site 762051004616 sequence-specific DNA binding site [nucleotide binding]; other site 762051004617 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 762051004618 non-specific DNA binding site [nucleotide binding]; other site 762051004619 salt bridge; other site 762051004620 sequence-specific DNA binding site [nucleotide binding]; other site 762051004621 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 762051004622 Ligand binding site; other site 762051004623 Putative Catalytic site; other site 762051004624 DXD motif; other site 762051004625 Predicted membrane protein [Function unknown]; Region: COG2246 762051004626 GtrA-like protein; Region: GtrA; pfam04138 762051004627 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 762051004628 potential frameshift: common BLAST hit: gi|288904583|ref|YP_003429804.1| Predicted membrane protein 762051004629 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 762051004630 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 762051004631 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 762051004632 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 762051004633 active pocket/dimerization site; other site 762051004634 active site 762051004635 phosphorylation site [posttranslational modification] 762051004636 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 762051004637 active site 762051004638 phosphorylation site [posttranslational modification] 762051004639 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 762051004640 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 762051004641 Domain of unknown function (DUF956); Region: DUF956; cl01917 762051004642 Uncharacterized conserved protein [Function unknown]; Region: COG1284 762051004643 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 762051004644 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 762051004645 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 762051004646 oligomerisation interface [polypeptide binding]; other site 762051004647 mobile loop; other site 762051004648 roof hairpin; other site 762051004649 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 762051004650 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 762051004651 ring oligomerisation interface [polypeptide binding]; other site 762051004652 ATP/Mg binding site [chemical binding]; other site 762051004653 stacking interactions; other site 762051004654 hinge regions; other site 762051004655 Predicted transcriptional regulators [Transcription]; Region: COG1695 762051004656 Transcriptional regulator PadR-like family; Region: PadR; cl17335 762051004657 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 762051004658 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762051004659 putative substrate translocation pore; other site 762051004660 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 762051004661 trimer interface [polypeptide binding]; other site 762051004662 active site 762051004663 G bulge; other site 762051004664 Protein of unknown function (DUF3290); Region: DUF3290; pfam11694 762051004665 Predicted membrane protein [Function unknown]; Region: COG2323 762051004666 1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; cl17224 762051004667 UbiA prenyltransferase family; Region: UbiA; pfam01040 762051004668 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 762051004669 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 762051004670 putative active site [active] 762051004671 catalytic residue [active] 762051004672 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 762051004673 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 762051004674 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 762051004675 ATP binding site [chemical binding]; other site 762051004676 putative Mg++ binding site [ion binding]; other site 762051004677 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 762051004678 nucleotide binding region [chemical binding]; other site 762051004679 ATP-binding site [chemical binding]; other site 762051004680 TRCF domain; Region: TRCF; pfam03461 762051004681 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 762051004682 RNA binding surface [nucleotide binding]; other site 762051004683 Septum formation initiator; Region: DivIC; pfam04977 762051004684 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 762051004685 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 762051004686 Ligand Binding Site [chemical binding]; other site 762051004687 TilS substrate C-terminal domain; Region: TilS_C; smart00977 762051004688 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 762051004689 active site 762051004690 ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465 762051004691 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 762051004692 Walker A motif; other site 762051004693 ATP binding site [chemical binding]; other site 762051004694 Walker B motif; other site 762051004695 arginine finger; other site 762051004696 Peptidase family M41; Region: Peptidase_M41; pfam01434 762051004697 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 762051004698 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 762051004699 dimerization interface [polypeptide binding]; other site 762051004700 domain crossover interface; other site 762051004701 redox-dependent activation switch; other site 762051004702 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 762051004703 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 762051004704 dimer interface [polypeptide binding]; other site 762051004705 putative anticodon binding site; other site 762051004706 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 762051004707 motif 1; other site 762051004708 active site 762051004709 motif 2; other site 762051004710 motif 3; other site 762051004711 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 762051004712 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 762051004713 active site 762051004714 metal binding site [ion binding]; metal-binding site 762051004715 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 762051004716 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762051004717 putative substrate translocation pore; other site 762051004718 Major Facilitator Superfamily; Region: MFS_1; pfam07690 762051004719 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 762051004720 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4487 762051004721 Uncharacterized protein conserved in bacteria (DUF2130); Region: DUF2130; pfam09903 762051004722 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 762051004723 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 762051004724 Predicted transcriptional regulators [Transcription]; Region: COG1733 762051004725 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 762051004726 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 762051004727 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 762051004728 Walker A/P-loop; other site 762051004729 ATP binding site [chemical binding]; other site 762051004730 Q-loop/lid; other site 762051004731 ABC transporter signature motif; other site 762051004732 Walker B; other site 762051004733 D-loop; other site 762051004734 H-loop/switch region; other site 762051004735 FtsX-like permease family; Region: FtsX; pfam02687 762051004736 FtsX-like permease family; Region: FtsX; pfam02687 762051004737 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 762051004738 active site 762051004739 HIGH motif; other site 762051004740 nucleotide binding site [chemical binding]; other site 762051004741 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 762051004742 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 762051004743 motif II; other site 762051004744 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 762051004745 ligand binding site [chemical binding]; other site 762051004746 flexible hinge region; other site 762051004747 LytTr DNA-binding domain; Region: LytTR; smart00850 762051004748 Protein of unknown function (DUF3021); Region: DUF3021; pfam11457 762051004749 Topoisomerase IA [DNA replication, recombination, and repair]; Region: TopA; COG0550 762051004750 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 762051004751 active site 762051004752 putative interdomain interaction site [polypeptide binding]; other site 762051004753 putative metal-binding site [ion binding]; other site 762051004754 putative nucleotide binding site [chemical binding]; other site 762051004755 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cl11986 762051004756 domain I; other site 762051004757 DNA binding groove [nucleotide binding] 762051004758 phosphate binding site [ion binding]; other site 762051004759 domain II; other site 762051004760 domain III; other site 762051004761 nucleotide binding site [chemical binding]; other site 762051004762 catalytic site [active] 762051004763 domain IV; other site 762051004764 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 762051004765 Cobalt transport protein; Region: CbiQ; cl00463 762051004766 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 762051004767 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 762051004768 Walker A/P-loop; other site 762051004769 ATP binding site [chemical binding]; other site 762051004770 Q-loop/lid; other site 762051004771 ABC transporter signature motif; other site 762051004772 Walker B; other site 762051004773 D-loop; other site 762051004774 H-loop/switch region; other site 762051004775 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 762051004776 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 762051004777 Walker A/P-loop; other site 762051004778 ATP binding site [chemical binding]; other site 762051004779 Q-loop/lid; other site 762051004780 ABC transporter signature motif; other site 762051004781 Walker B; other site 762051004782 D-loop; other site 762051004783 H-loop/switch region; other site 762051004784 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; pfam09819 762051004785 RibD C-terminal domain; Region: RibD_C; cl17279 762051004786 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 762051004787 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 762051004788 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 762051004789 tetramer interfaces [polypeptide binding]; other site 762051004790 binuclear metal-binding site [ion binding]; other site 762051004791 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 762051004792 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 762051004793 active site 762051004794 dimer interface [polypeptide binding]; other site 762051004795 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 762051004796 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762051004797 DNA-binding site [nucleotide binding]; DNA binding site 762051004798 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 762051004799 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762051004800 dimer interface [polypeptide binding]; other site 762051004801 conserved gate region; other site 762051004802 ABC-ATPase subunit interface; other site 762051004803 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 762051004804 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 762051004805 Walker A/P-loop; other site 762051004806 ATP binding site [chemical binding]; other site 762051004807 Q-loop/lid; other site 762051004808 ABC transporter signature motif; other site 762051004809 Walker B; other site 762051004810 D-loop; other site 762051004811 H-loop/switch region; other site 762051004812 NIL domain; Region: NIL; pfam09383 762051004813 hypothetical protein; Provisional; Region: PRK06446 762051004814 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_4; cd05681 762051004815 metal binding site [ion binding]; metal-binding site 762051004816 dimer interface [polypeptide binding]; other site 762051004817 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 762051004818 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 762051004819 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 762051004820 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 762051004821 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 762051004822 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 762051004823 Protein of unknown function (DUF2721); Region: DUF2721; pfam11026 762051004824 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 762051004825 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 762051004826 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 762051004827 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 762051004828 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 762051004829 motif II; other site 762051004830 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 762051004831 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 762051004832 metal binding site 2 [ion binding]; metal-binding site 762051004833 putative DNA binding helix; other site 762051004834 metal binding site 1 [ion binding]; metal-binding site 762051004835 dimer interface [polypeptide binding]; other site 762051004836 structural Zn2+ binding site [ion binding]; other site 762051004837 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 762051004838 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 762051004839 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 762051004840 Protein of unknown function (DUF1054); Region: DUF1054; pfam06335 762051004841 S-adenosylmethionine synthetase; Validated; Region: PRK05250 762051004842 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 762051004843 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 762051004844 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 762051004845 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 762051004846 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 762051004847 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 762051004848 phosphoenolpyruvate carboxylase; Provisional; Region: PRK13655 762051004849 phosphoenolpyruvate carboxylase, archaeal type; Region: PEPCase_arch; TIGR02751 762051004850 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 762051004851 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 762051004852 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 762051004853 Protein of unknown function (DUF1447); Region: DUF1447; pfam07288 762051004854 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 762051004855 Transcriptional regulators [Transcription]; Region: MarR; COG1846 762051004856 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 762051004857 elongation factor P; Validated; Region: PRK00529 762051004858 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 762051004859 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 762051004860 RNA binding site [nucleotide binding]; other site 762051004861 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 762051004862 RNA binding site [nucleotide binding]; other site 762051004863 Asp23 family; Region: Asp23; pfam03780 762051004864 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 762051004865 putative RNA binding site [nucleotide binding]; other site 762051004866 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 762051004867 active site 762051004868 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 762051004869 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 762051004870 putative active site [active] 762051004871 putative metal binding site [ion binding]; other site 762051004872 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 762051004873 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 762051004874 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 762051004875 S-adenosylmethionine binding site [chemical binding]; other site 762051004876 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 762051004877 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 762051004878 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 762051004879 intersubunit interface [polypeptide binding]; other site 762051004880 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 762051004881 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 762051004882 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 762051004883 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 762051004884 putative PBP binding regions; other site 762051004885 ABC-ATPase subunit interface; other site 762051004886 pur operon repressor; Provisional; Region: PRK09213 762051004887 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 762051004888 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 762051004889 active site 762051004890 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 762051004891 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 762051004892 Substrate binding site; other site 762051004893 Mg++ binding site; other site 762051004894 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 762051004895 active site 762051004896 substrate binding site [chemical binding]; other site 762051004897 CoA binding site [chemical binding]; other site 762051004898 SLBB domain; Region: SLBB; pfam10531 762051004899 comEA protein; Region: comE; TIGR01259 762051004900 Helix-hairpin-helix motif; Region: HHH; pfam00633 762051004901 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 762051004902 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 762051004903 Competence protein; Region: Competence; pfam03772 762051004904 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 762051004905 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 762051004906 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 762051004907 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 762051004908 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 762051004909 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 762051004910 16S/18S rRNA binding site [nucleotide binding]; other site 762051004911 S13e-L30e interaction site [polypeptide binding]; other site 762051004912 25S rRNA binding site [nucleotide binding]; other site 762051004913 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 762051004914 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 762051004915 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 762051004916 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 762051004917 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 762051004918 GatB domain; Region: GatB_Yqey; smart00845 762051004919 putative lipid kinase; Reviewed; Region: PRK13055 762051004920 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 762051004921 Predicted RNA-binding protein, contains TRAM domain [General function prediction only]; Region: COG3269 762051004922 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 762051004923 CTP synthetase; Validated; Region: pyrG; PRK05380 762051004924 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 762051004925 Catalytic site [active] 762051004926 active site 762051004927 UTP binding site [chemical binding]; other site 762051004928 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 762051004929 active site 762051004930 putative oxyanion hole; other site 762051004931 catalytic triad [active] 762051004932 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 762051004933 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 762051004934 GIY-YIG motif/motif A; other site 762051004935 active site 762051004936 catalytic site [active] 762051004937 putative DNA binding site [nucleotide binding]; other site 762051004938 metal binding site [ion binding]; metal-binding site 762051004939 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 762051004940 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 762051004941 DNA binding site [nucleotide binding] 762051004942 GTPase CgtA; Reviewed; Region: obgE; PRK12297 762051004943 GTP1/OBG; Region: GTP1_OBG; pfam01018 762051004944 Obg GTPase; Region: Obg; cd01898 762051004945 G1 box; other site 762051004946 GTP/Mg2+ binding site [chemical binding]; other site 762051004947 Switch I region; other site 762051004948 G2 box; other site 762051004949 G3 box; other site 762051004950 Switch II region; other site 762051004951 G4 box; other site 762051004952 G5 box; other site 762051004953 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 762051004954 acetolactate synthase; Reviewed; Region: PRK08617 762051004955 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 762051004956 PYR/PP interface [polypeptide binding]; other site 762051004957 dimer interface [polypeptide binding]; other site 762051004958 TPP binding site [chemical binding]; other site 762051004959 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 762051004960 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 762051004961 TPP-binding site [chemical binding]; other site 762051004962 potential frameshift: common BLAST hit: gi|170017682|ref|YP_001728601.1| anaerobic ribonucleoside triphosphate reductase 762051004963 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 762051004964 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 762051004965 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 762051004966 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 762051004967 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 762051004968 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 762051004969 Walker A/P-loop; other site 762051004970 ATP binding site [chemical binding]; other site 762051004971 Q-loop/lid; other site 762051004972 ABC transporter signature motif; other site 762051004973 Walker B; other site 762051004974 D-loop; other site 762051004975 H-loop/switch region; other site 762051004976 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 762051004977 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 762051004978 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 762051004979 active site 762051004980 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 762051004981 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 762051004982 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 762051004983 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_b; cd04185 762051004984 Probable Catalytic site; other site 762051004985 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 762051004986 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 762051004987 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 762051004988 legume lectins; Region: lectin_L-type; cd01951 762051004989 homotetramer interaction site [polypeptide binding]; other site 762051004990 carbohydrate binding site [chemical binding]; other site 762051004991 metal binding site [ion binding]; metal-binding site 762051004992 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 762051004993 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 762051004994 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 762051004995 beta-1,6-galactofuranosyltransferase; Provisional; Region: PRK09814 762051004996 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 762051004997 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 762051004998 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 762051004999 Coenzyme A binding pocket [chemical binding]; other site 762051005000 thymidylate synthase; Region: thym_sym; TIGR03284 762051005001 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 762051005002 dimerization interface [polypeptide binding]; other site 762051005003 active site 762051005004 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 762051005005 catalytic motif [active] 762051005006 Zn binding site [ion binding]; other site 762051005007 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 762051005008 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190 762051005009 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 762051005010 homodimer interface [polypeptide binding]; other site 762051005011 NADP binding site [chemical binding]; other site 762051005012 substrate binding site [chemical binding]; other site 762051005013 Zinc finger domain containing protein (CHY type) [Function unknown]; Region: COG4357 762051005014 CHY zinc finger; Region: zf-CHY; pfam05495 762051005015 BioY family; Region: BioY; pfam02632 762051005016 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 762051005017 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762051005018 DNA-binding site [nucleotide binding]; DNA binding site 762051005019 TrkA-C domain; Region: TrkA_C; pfam02080 762051005020 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 762051005021 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 762051005022 Walker A/P-loop; other site 762051005023 ATP binding site [chemical binding]; other site 762051005024 Q-loop/lid; other site 762051005025 ABC transporter signature motif; other site 762051005026 Walker B; other site 762051005027 D-loop; other site 762051005028 H-loop/switch region; other site 762051005029 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 762051005030 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 762051005031 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762051005032 dimer interface [polypeptide binding]; other site 762051005033 conserved gate region; other site 762051005034 putative PBP binding loops; other site 762051005035 ABC-ATPase subunit interface; other site 762051005036 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 762051005037 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 762051005038 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 762051005039 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 762051005040 active site 762051005041 catalytic tetrad [active] 762051005042 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 762051005043 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 762051005044 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 762051005045 Walker A/P-loop; other site 762051005046 ATP binding site [chemical binding]; other site 762051005047 Q-loop/lid; other site 762051005048 ABC transporter signature motif; other site 762051005049 Walker B; other site 762051005050 D-loop; other site 762051005051 H-loop/switch region; other site 762051005052 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 762051005053 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 762051005054 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 762051005055 non-specific DNA binding site [nucleotide binding]; other site 762051005056 salt bridge; other site 762051005057 sequence-specific DNA binding site [nucleotide binding]; other site 762051005058 Protein of unknown function (DUF1706); Region: DUF1706; pfam08020 762051005059 VanW like protein; Region: VanW; pfam04294 762051005060 Protein of unknown function (DUF1440); Region: DUF1440; pfam07274 762051005061 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 762051005062 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 762051005063 NAD(P) binding site [chemical binding]; other site 762051005064 catalytic residues [active] 762051005065 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 762051005066 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 762051005067 catalytic residues [active] 762051005068 catalytic nucleophile [active] 762051005069 Presynaptic Site I dimer interface [polypeptide binding]; other site 762051005070 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 762051005071 Synaptic Flat tetramer interface [polypeptide binding]; other site 762051005072 Synaptic Site I dimer interface [polypeptide binding]; other site 762051005073 DNA binding site [nucleotide binding] 762051005074 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 762051005075 metal ion-dependent adhesion site (MIDAS); other site 762051005076 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 762051005077 domain interaction interfaces [polypeptide binding]; other site 762051005078 Cna protein B-type domain; Region: Cna_B; pfam05738 762051005079 Cna protein B-type domain; Region: Cna_B; pfam05738 762051005080 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 762051005081 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 762051005082 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 762051005083 active site 762051005084 catalytic site [active] 762051005085 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 762051005086 active site 762051005087 catalytic site [active] 762051005088 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 762051005089 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 762051005090 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 762051005091 generic binding surface II; other site 762051005092 ssDNA binding site; other site 762051005093 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 762051005094 ATP binding site [chemical binding]; other site 762051005095 putative Mg++ binding site [ion binding]; other site 762051005096 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 762051005097 nucleotide binding region [chemical binding]; other site 762051005098 ATP-binding site [chemical binding]; other site 762051005099 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 762051005100 MutS domain I; Region: MutS_I; pfam01624 762051005101 MutS domain II; Region: MutS_II; pfam05188 762051005102 MutS domain III; Region: MutS_III; pfam05192 762051005103 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 762051005104 Walker A/P-loop; other site 762051005105 ATP binding site [chemical binding]; other site 762051005106 Q-loop/lid; other site 762051005107 ABC transporter signature motif; other site 762051005108 Walker B; other site 762051005109 D-loop; other site 762051005110 H-loop/switch region; other site 762051005111 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 762051005112 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762051005113 ATP binding site [chemical binding]; other site 762051005114 Mg2+ binding site [ion binding]; other site 762051005115 G-X-G motif; other site 762051005116 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 762051005117 ATP binding site [chemical binding]; other site 762051005118 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 762051005119 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 762051005120 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 762051005121 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 762051005122 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 762051005123 active site 762051005124 multimer interface [polypeptide binding]; other site 762051005125 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 762051005126 FAD binding domain; Region: FAD_binding_4; pfam01565 762051005127 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 762051005128 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 762051005129 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 762051005130 TIGR00159 family protein; Region: TIGR00159 762051005131 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 762051005132 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 762051005133 YbbR-like protein; Region: YbbR; pfam07949 762051005134 YbbR-like protein; Region: YbbR; pfam07949 762051005135 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 762051005136 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 762051005137 active site 762051005138 substrate binding site [chemical binding]; other site 762051005139 metal binding site [ion binding]; metal-binding site 762051005140 ribonuclease III; Reviewed; Region: rnc; PRK00102 762051005141 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 762051005142 dimerization interface [polypeptide binding]; other site 762051005143 active site 762051005144 metal binding site [ion binding]; metal-binding site 762051005145 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 762051005146 dsRNA binding site [nucleotide binding]; other site 762051005147 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 762051005148 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 762051005149 Walker A/P-loop; other site 762051005150 ATP binding site [chemical binding]; other site 762051005151 Q-loop/lid; other site 762051005152 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 762051005153 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 762051005154 ABC transporter signature motif; other site 762051005155 Walker B; other site 762051005156 D-loop; other site 762051005157 H-loop/switch region; other site 762051005158 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 762051005159 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 762051005160 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 762051005161 P loop; other site 762051005162 GTP binding site [chemical binding]; other site 762051005163 putative DNA-binding protein; Validated; Region: PRK00118 762051005164 signal recognition particle protein; Provisional; Region: PRK10867 762051005165 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 762051005166 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 762051005167 P loop; other site 762051005168 GTP binding site [chemical binding]; other site 762051005169 Signal peptide binding domain; Region: SRP_SPB; pfam02978 762051005170 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 762051005171 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 762051005172 active site 762051005173 motif I; other site 762051005174 motif II; other site 762051005175 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 762051005176 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 762051005177 beta-galactosidase; Region: BGL; TIGR03356 762051005178 cellobiose phosphotransferase system IIB component; Reviewed; Region: celB; PRK09590 762051005179 active site 762051005180 P-loop; other site 762051005181 phosphorylation site [posttranslational modification] 762051005182 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 762051005183 HTH domain; Region: HTH_11; pfam08279 762051005184 Mga helix-turn-helix domain; Region: Mga; pfam05043 762051005185 PRD domain; Region: PRD; pfam00874 762051005186 PRD domain; Region: PRD; pfam00874 762051005187 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 762051005188 active site 762051005189 P-loop; other site 762051005190 phosphorylation site [posttranslational modification] 762051005191 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 762051005192 active site 762051005193 phosphorylation site [posttranslational modification] 762051005194 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 762051005195 methionine cluster; other site 762051005196 active site 762051005197 phosphorylation site [posttranslational modification] 762051005198 metal binding site [ion binding]; metal-binding site 762051005199 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 762051005200 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 762051005201 histidinol-phosphatase; Reviewed; Region: PRK08123 762051005202 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 762051005203 active site 762051005204 dimer interface [polypeptide binding]; other site 762051005205 ATP phosphoribosyltransferase, regulatory subunit; Region: hisZ_biosyn_reg; TIGR00443 762051005206 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 762051005207 dimer interface [polypeptide binding]; other site 762051005208 motif 1; other site 762051005209 active site 762051005210 motif 2; other site 762051005211 motif 3; other site 762051005212 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 762051005213 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 762051005214 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 762051005215 histidinol dehydrogenase; Region: hisD; TIGR00069 762051005216 NAD binding site [chemical binding]; other site 762051005217 dimerization interface [polypeptide binding]; other site 762051005218 product binding site; other site 762051005219 substrate binding site [chemical binding]; other site 762051005220 zinc binding site [ion binding]; other site 762051005221 catalytic residues [active] 762051005222 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 762051005223 putative active site pocket [active] 762051005224 4-fold oligomerization interface [polypeptide binding]; other site 762051005225 metal binding residues [ion binding]; metal-binding site 762051005226 3-fold/trimer interface [polypeptide binding]; other site 762051005227 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 762051005228 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 762051005229 putative active site [active] 762051005230 oxyanion strand; other site 762051005231 catalytic triad [active] 762051005232 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 762051005233 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 762051005234 catalytic residues [active] 762051005235 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 762051005236 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 762051005237 substrate binding site [chemical binding]; other site 762051005238 glutamase interaction surface [polypeptide binding]; other site 762051005239 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 762051005240 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 762051005241 metal binding site [ion binding]; metal-binding site 762051005242 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 762051005243 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 762051005244 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762051005245 homodimer interface [polypeptide binding]; other site 762051005246 catalytic residue [active] 762051005247 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 762051005248 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 762051005249 GDP-binding site [chemical binding]; other site 762051005250 ACT binding site; other site 762051005251 IMP binding site; other site 762051005252 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 762051005253 AAA domain; Region: AAA_30; pfam13604 762051005254 Uncharacterized conserved protein (DUF2075); Region: DUF2075; pfam09848 762051005255 Uncharacterized conserved protein [Function unknown]; Region: COG3410 762051005256 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 762051005257 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 762051005258 Walker A motif; other site 762051005259 ATP binding site [chemical binding]; other site 762051005260 Walker B motif; other site 762051005261 arginine finger; other site 762051005262 UvrB/uvrC motif; Region: UVR; pfam02151 762051005263 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 762051005264 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 762051005265 Walker A motif; other site 762051005266 ATP binding site [chemical binding]; other site 762051005267 Walker B motif; other site 762051005268 arginine finger; other site 762051005269 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 762051005270 rod shape-determining protein MreB; Provisional; Region: PRK13927 762051005271 MreB and similar proteins; Region: MreB_like; cd10225 762051005272 nucleotide binding site [chemical binding]; other site 762051005273 Mg binding site [ion binding]; other site 762051005274 putative protofilament interaction site [polypeptide binding]; other site 762051005275 RodZ interaction site [polypeptide binding]; other site 762051005276 rod shape-determining protein MreC; Provisional; Region: PRK13922 762051005277 rod shape-determining protein MreC; Region: MreC; pfam04085 762051005278 rod shape-determining protein MreD; Region: MreD; cl01087 762051005279 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 762051005280 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762051005281 dimer interface [polypeptide binding]; other site 762051005282 conserved gate region; other site 762051005283 putative PBP binding loops; other site 762051005284 ABC-ATPase subunit interface; other site 762051005285 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 762051005286 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 762051005287 Walker A/P-loop; other site 762051005288 ATP binding site [chemical binding]; other site 762051005289 Q-loop/lid; other site 762051005290 ABC transporter signature motif; other site 762051005291 Walker B; other site 762051005292 D-loop; other site 762051005293 H-loop/switch region; other site 762051005294 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 762051005295 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 762051005296 substrate binding pocket [chemical binding]; other site 762051005297 membrane-bound complex binding site; other site 762051005298 hinge residues; other site 762051005299 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 762051005300 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 762051005301 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 762051005302 putative active site [active] 762051005303 catalytic site [active] 762051005304 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 762051005305 putative active site [active] 762051005306 catalytic site [active] 762051005307 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 762051005308 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 762051005309 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 762051005310 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 762051005311 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 762051005312 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 762051005313 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 762051005314 non-specific DNA binding site [nucleotide binding]; other site 762051005315 salt bridge; other site 762051005316 sequence-specific DNA binding site [nucleotide binding]; other site 762051005317 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Region: pgsA; TIGR00560 762051005318 recombinase A; Provisional; Region: recA; PRK09354 762051005319 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 762051005320 hexamer interface [polypeptide binding]; other site 762051005321 Walker A motif; other site 762051005322 ATP binding site [chemical binding]; other site 762051005323 Walker B motif; other site 762051005324 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 762051005325 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 762051005326 active site 762051005327 phosphorylation site [posttranslational modification] 762051005328 intermolecular recognition site; other site 762051005329 dimerization interface [polypeptide binding]; other site 762051005330 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 762051005331 DNA binding site [nucleotide binding] 762051005332 PBP superfamily domain; Region: PBP_like_2; cl17296 762051005333 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 762051005334 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 762051005335 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 762051005336 dimer interface [polypeptide binding]; other site 762051005337 phosphorylation site [posttranslational modification] 762051005338 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762051005339 ATP binding site [chemical binding]; other site 762051005340 Mg2+ binding site [ion binding]; other site 762051005341 G-X-G motif; other site 762051005342 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 762051005343 PBP superfamily domain; Region: PBP_like_2; cl17296 762051005344 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 762051005345 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762051005346 dimer interface [polypeptide binding]; other site 762051005347 conserved gate region; other site 762051005348 putative PBP binding loops; other site 762051005349 ABC-ATPase subunit interface; other site 762051005350 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 762051005351 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762051005352 dimer interface [polypeptide binding]; other site 762051005353 conserved gate region; other site 762051005354 putative PBP binding loops; other site 762051005355 ABC-ATPase subunit interface; other site 762051005356 phosphate transporter ATP-binding protein; Provisional; Region: PRK14237 762051005357 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 762051005358 Walker A/P-loop; other site 762051005359 ATP binding site [chemical binding]; other site 762051005360 Q-loop/lid; other site 762051005361 ABC transporter signature motif; other site 762051005362 Walker B; other site 762051005363 D-loop; other site 762051005364 H-loop/switch region; other site 762051005365 phosphate transporter ATP-binding protein; Provisional; Region: PRK14239 762051005366 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 762051005367 Walker A/P-loop; other site 762051005368 ATP binding site [chemical binding]; other site 762051005369 Q-loop/lid; other site 762051005370 ABC transporter signature motif; other site 762051005371 Walker B; other site 762051005372 D-loop; other site 762051005373 H-loop/switch region; other site 762051005374 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 762051005375 PhoU domain; Region: PhoU; pfam01895 762051005376 PhoU domain; Region: PhoU; pfam01895 762051005377 Membrane protein of unknown function; Region: DUF360; pfam04020 762051005378 HPr kinase/phosphorylase; Provisional; Region: PRK05428 762051005379 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 762051005380 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 762051005381 Hpr binding site; other site 762051005382 active site 762051005383 homohexamer subunit interaction site [polypeptide binding]; other site 762051005384 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 762051005385 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 762051005386 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 762051005387 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 762051005388 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 762051005389 active site 762051005390 tetramer interface; other site 762051005391 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 762051005392 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 762051005393 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 762051005394 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762051005395 Major Facilitator Superfamily; Region: MFS_1; pfam07690 762051005396 putative substrate translocation pore; other site 762051005397 Alpha amylase catalytic domain found in sucrose phosphorylase (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase; cd11355 762051005398 sucrose phosphorylase; Region: sucrose_gtfA; TIGR03852 762051005399 active site 762051005400 homodimer interface [polypeptide binding]; other site 762051005401 catalytic site [active] 762051005402 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 762051005403 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 762051005404 active site 762051005405 substrate binding site [chemical binding]; other site 762051005406 metal binding site [ion binding]; metal-binding site 762051005407 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 762051005408 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 762051005409 active site 762051005410 DNA polymerase IV; Validated; Region: PRK02406 762051005411 DNA binding site [nucleotide binding] 762051005412 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 762051005413 DHH family; Region: DHH; pfam01368 762051005414 DHHA1 domain; Region: DHHA1; pfam02272 762051005415 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 762051005416 DEAD-like helicases superfamily; Region: DEXDc; smart00487 762051005417 ATP binding site [chemical binding]; other site 762051005418 Mg++ binding site [ion binding]; other site 762051005419 motif III; other site 762051005420 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 762051005421 nucleotide binding region [chemical binding]; other site 762051005422 ATP-binding site [chemical binding]; other site 762051005423 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 762051005424 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 762051005425 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 762051005426 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 762051005427 acyl-activating enzyme (AAE) consensus motif; other site 762051005428 AMP binding site [chemical binding]; other site 762051005429 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 762051005430 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 762051005431 potential frameshift: common BLAST hit: gi|170017586|ref|YP_001728505.1| D-alanyl transfer protein DltD 762051005432 D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092 762051005433 DltD N-terminal region; Region: DltD_N; pfam04915 762051005434 DltD central region; Region: DltD_M; pfam04918 762051005435 DltD C-terminal region; Region: DltD_C; pfam04914 762051005436 DltD C-terminal region; Region: DltD_C; pfam04914 762051005437 Protein of unknown function (DUF2507); Region: DUF2507; pfam10702 762051005438 glutamate racemase; Provisional; Region: PRK00865 762051005439 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 762051005440 active site 762051005441 dimerization interface [polypeptide binding]; other site 762051005442 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 762051005443 active site 762051005444 metal binding site [ion binding]; metal-binding site 762051005445 homotetramer interface [polypeptide binding]; other site 762051005446 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 762051005447 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 762051005448 Walker A motif; other site 762051005449 ATP binding site [chemical binding]; other site 762051005450 Walker B motif; other site 762051005451 arginine finger; other site 762051005452 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 762051005453 Aquifex aeolicus AQ1575 and related proteins, metallophosphatase domain; Region: MPP_AQ1575; cd07390 762051005454 putative active site [active] 762051005455 putative metal binding site [ion binding]; other site 762051005456 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 762051005457 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 762051005458 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 762051005459 RuvA N terminal domain; Region: RuvA_N; pfam01330 762051005460 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 762051005461 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 762051005462 Substrate-binding site [chemical binding]; other site 762051005463 Substrate specificity [chemical binding]; other site 762051005464 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 762051005465 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 762051005466 Uncharacterized conserved protein [Function unknown]; Region: COG3402 762051005467 Predicted membrane protein [Function unknown]; Region: COG3428 762051005468 Bacterial PH domain; Region: DUF304; pfam03703 762051005469 Bacterial PH domain; Region: DUF304; pfam03703 762051005470 Bacterial PH domain; Region: DUF304; pfam03703 762051005471 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 762051005472 HTH domain; Region: HTH_11; pfam08279 762051005473 Mga helix-turn-helix domain; Region: Mga; pfam05043 762051005474 PRD domain; Region: PRD; pfam00874 762051005475 PRD domain; Region: PRD; pfam00874 762051005476 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 762051005477 active site 762051005478 P-loop; other site 762051005479 phosphorylation site [posttranslational modification] 762051005480 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 762051005481 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 762051005482 active site 762051005483 phosphorylation site [posttranslational modification] 762051005484 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 762051005485 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 762051005486 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 762051005487 active site 762051005488 P-loop; other site 762051005489 phosphorylation site [posttranslational modification] 762051005490 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C); Region: NT5C; cl17836 762051005491 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 762051005492 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 762051005493 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 762051005494 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 762051005495 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 762051005496 putative substrate binding site [chemical binding]; other site 762051005497 putative ATP binding site [chemical binding]; other site 762051005498 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 762051005499 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 762051005500 active site 762051005501 phosphorylation site [posttranslational modification] 762051005502 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 762051005503 active site 762051005504 P-loop; other site 762051005505 phosphorylation site [posttranslational modification] 762051005506 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 762051005507 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 762051005508 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 762051005509 DNA binding site [nucleotide binding] 762051005510 active site 762051005511 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 762051005512 RimM N-terminal domain; Region: RimM; pfam01782 762051005513 PRC-barrel domain; Region: PRC; pfam05239 762051005514 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 762051005515 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 762051005516 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 762051005517 Glycosyl hydrolase family 70; Region: Glyco_hydro_70; pfam02324 762051005518 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 762051005519 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 762051005520 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 762051005521 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 762051005522 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 762051005523 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 762051005524 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 762051005525 active site 762051005526 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 762051005527 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 762051005528 substrate binding site; other site 762051005529 tetramer interface; other site 762051005530 Bacterial sugar transferase; Region: Bac_transf; pfam02397 762051005531 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 762051005532 putative ADP-binding pocket [chemical binding]; other site 762051005533 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 762051005534 Protein of unknown function (DUF3184); Region: DUF3184; pfam11380 762051005535 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 762051005536 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 762051005537 Walker A/P-loop; other site 762051005538 ATP binding site [chemical binding]; other site 762051005539 Q-loop/lid; other site 762051005540 ABC transporter signature motif; other site 762051005541 Walker B; other site 762051005542 D-loop; other site 762051005543 H-loop/switch region; other site 762051005544 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 762051005545 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 762051005546 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 762051005547 active site 762051005548 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 762051005549 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 762051005550 accessory Sec system protein Asp2; Region: acc_sec_asp2; TIGR03712 762051005551 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 762051005552 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 762051005553 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 762051005554 active site 762051005555 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 762051005556 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 762051005557 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 762051005558 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 762051005559 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 762051005560 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 762051005561 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 762051005562 NAD binding site [chemical binding]; other site 762051005563 substrate binding site [chemical binding]; other site 762051005564 homodimer interface [polypeptide binding]; other site 762051005565 active site 762051005566 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 762051005567 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 762051005568 NADP binding site [chemical binding]; other site 762051005569 active site 762051005570 putative substrate binding site [chemical binding]; other site 762051005571 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 762051005572 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 762051005573 Transposase; Region: HTH_Tnp_1; pfam01527 762051005574 HTH-like domain; Region: HTH_21; pfam13276 762051005575 Integrase core domain; Region: rve; pfam00665 762051005576 Integrase core domain; Region: rve_3; cl15866 762051005577 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 762051005578 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 762051005579 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 762051005580 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 762051005581 methionine sulfoxide reductase A; Provisional; Region: PRK14054 762051005582 ribonuclease Z; Region: RNase_Z; TIGR02651 762051005583 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 762051005584 DHH family; Region: DHH; pfam01368 762051005585 Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; cl11538 762051005586 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 762051005587 active site 762051005588 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 762051005589 Thioredoxin; Region: Thioredoxin_5; pfam13743 762051005590 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 762051005591 synthetase active site [active] 762051005592 NTP binding site [chemical binding]; other site 762051005593 metal binding site [ion binding]; metal-binding site 762051005594 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 762051005595 ATP-NAD kinase; Region: NAD_kinase; pfam01513 762051005596 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 762051005597 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 762051005598 active site 762051005599 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 762051005600 MgtE intracellular N domain; Region: MgtE_N; pfam03448 762051005601 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 762051005602 Divalent cation transporter; Region: MgtE; pfam01769 762051005603 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 762051005604 argininosuccinate synthase; Provisional; Region: PRK13820 762051005605 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 762051005606 ANP binding site [chemical binding]; other site 762051005607 Substrate Binding Site II [chemical binding]; other site 762051005608 Substrate Binding Site I [chemical binding]; other site 762051005609 argininosuccinate lyase; Provisional; Region: PRK00855 762051005610 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 762051005611 active sites [active] 762051005612 tetramer interface [polypeptide binding]; other site 762051005613 ornithine carbamoyltransferase; Validated; Region: PRK02102 762051005614 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 762051005615 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 762051005616 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762051005617 putative substrate translocation pore; other site 762051005618 Major Facilitator Superfamily; Region: MFS_1; pfam07690 762051005619 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762051005620 XFP N-terminal domain; Region: XFP_N; pfam09364 762051005621 putative phosphoketolase; Provisional; Region: PRK05261 762051005622 XFP C-terminal domain; Region: XFP_C; pfam09363 762051005623 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; cl17818 762051005624 Thymidylate synthase; Region: Thymidylat_synt; pfam00303 762051005625 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 762051005626 dimerization interface [polypeptide binding]; other site 762051005627 active site 762051005628 Methyltransferase domain; Region: Methyltransf_23; pfam13489 762051005629 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 762051005630 S-adenosylmethionine binding site [chemical binding]; other site 762051005631 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 762051005632 Domain of unknown function (DUF814); Region: DUF814; pfam05670 762051005633 CutC family; Region: CutC; cl01218 762051005634 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 762051005635 Nicotinamide mononucleotide transporter; Region: NMN_transporter; cl01256 762051005636 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014 762051005637 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 762051005638 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 762051005639 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 762051005640 non-specific DNA binding site [nucleotide binding]; other site 762051005641 salt bridge; other site 762051005642 sequence-specific DNA binding site [nucleotide binding]; other site 762051005643 putative nicotinate phosphoribosyltransferase; Provisional; Region: PRK09198 762051005644 Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an important role in NAD production by either allowing quinolinic acid (QA) , quinolinate phosphoribosyl transferase (QAPRTase), or nicotinic acid (NA), nicotinate...; Region: PRTase_typeII; cl17275 762051005645 active site 762051005646 diaminopimelate decarboxylase; Region: lysA; TIGR01048 762051005647 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 762051005648 active site 762051005649 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 762051005650 substrate binding site [chemical binding]; other site 762051005651 catalytic residues [active] 762051005652 dimer interface [polypeptide binding]; other site 762051005653 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 762051005654 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 762051005655 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 762051005656 putative trimer interface [polypeptide binding]; other site 762051005657 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 762051005658 putative CoA binding site [chemical binding]; other site 762051005659 putative trimer interface [polypeptide binding]; other site 762051005660 putative CoA binding site [chemical binding]; other site 762051005661 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 762051005662 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 762051005663 metal binding site [ion binding]; metal-binding site 762051005664 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 762051005665 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 762051005666 dimer interface [polypeptide binding]; other site 762051005667 active site 762051005668 catalytic residue [active] 762051005669 dihydrodipicolinate reductase; Provisional; Region: PRK00048 762051005670 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 762051005671 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 762051005672 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 762051005673 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 762051005674 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 762051005675 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 762051005676 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 762051005677 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 762051005678 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 762051005679 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 762051005680 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 762051005681 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 762051005682 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 762051005683 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 762051005684 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 762051005685 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 762051005686 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 762051005687 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 762051005688 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 762051005689 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 762051005690 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 762051005691 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 762051005692 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 762051005693 RecX family; Region: RecX; cl00936 762051005694 hypothetical protein; Provisional; Region: PRK13662 762051005695 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 762051005696 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 762051005697 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 762051005698 Part of AAA domain; Region: AAA_19; pfam13245 762051005699 Family description; Region: UvrD_C_2; pfam13538 762051005700 Rhomboid family; Region: Rhomboid; pfam01694 762051005701 Bacterial protein of unknown function (DUF910); Region: DUF910; pfam06014 762051005702 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 762051005703 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 762051005704 nucleotide binding site [chemical binding]; other site 762051005705 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 762051005706 active site 762051005707 Bacterial sugar transferase; Region: Bac_transf; pfam02397 762051005708 Domain of unknown function (DUF4422); Region: DUF4422; pfam14393 762051005709 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 762051005710 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 762051005711 UDP-galactopyranose mutase; Region: GLF; pfam03275 762051005712 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 762051005713 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 762051005714 Ligand binding site; other site 762051005715 Putative Catalytic site; other site 762051005716 DXD motif; other site 762051005717 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 762051005718 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 762051005719 active site 762051005720 nucleotide binding site [chemical binding]; other site 762051005721 HIGH motif; other site 762051005722 KMSKS motif; other site 762051005723 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 762051005724 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_b; cd04185 762051005725 Probable Catalytic site; other site 762051005726 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 762051005727 Sulfate transporter family; Region: Sulfate_transp; pfam00916 762051005728 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 762051005729 DNA-binding site [nucleotide binding]; DNA binding site 762051005730 RNA-binding motif; other site 762051005731 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 762051005732 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 762051005733 dimer interface [polypeptide binding]; other site 762051005734 ADP-ribose binding site [chemical binding]; other site 762051005735 active site 762051005736 nudix motif; other site 762051005737 metal binding site [ion binding]; metal-binding site 762051005738 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 762051005739 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 762051005740 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 762051005741 putative tRNA-binding site [nucleotide binding]; other site 762051005742 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 762051005743 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 762051005744 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 762051005745 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 762051005746 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 762051005747 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 762051005748 DNA polymerase I; Provisional; Region: PRK05755 762051005749 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 762051005750 active site 762051005751 metal binding site 1 [ion binding]; metal-binding site 762051005752 putative 5' ssDNA interaction site; other site 762051005753 metal binding site 3; metal-binding site 762051005754 metal binding site 2 [ion binding]; metal-binding site 762051005755 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 762051005756 putative DNA binding site [nucleotide binding]; other site 762051005757 putative metal binding site [ion binding]; other site 762051005758 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 762051005759 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 762051005760 active site 762051005761 DNA binding site [nucleotide binding] 762051005762 catalytic site [active] 762051005763 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 762051005764 DNA binding residues [nucleotide binding] 762051005765 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 762051005766 putative dimer interface [polypeptide binding]; other site 762051005767 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 762051005768 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 762051005769 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 762051005770 Uncharacterized conserved protein [Function unknown]; Region: COG1284 762051005771 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 762051005772 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 762051005773 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 762051005774 active site 1 [active] 762051005775 dimer interface [polypeptide binding]; other site 762051005776 hexamer interface [polypeptide binding]; other site 762051005777 active site 2 [active] 762051005778 Transcriptional regulators [Transcription]; Region: PurR; COG1609 762051005779 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 762051005780 DNA binding site [nucleotide binding] 762051005781 domain linker motif; other site 762051005782 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 762051005783 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 762051005784 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 762051005785 active site turn [active] 762051005786 phosphorylation site [posttranslational modification] 762051005787 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 762051005788 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 762051005789 HPr interaction site; other site 762051005790 glycerol kinase (GK) interaction site [polypeptide binding]; other site 762051005791 active site 762051005792 phosphorylation site [posttranslational modification] 762051005793 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 762051005794 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 762051005795 substrate binding [chemical binding]; other site 762051005796 active site 762051005797 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 762051005798 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 762051005799 nucleotide binding site [chemical binding]; other site 762051005800 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 762051005801 RNA/DNA hybrid binding site [nucleotide binding]; other site 762051005802 active site 762051005803 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 762051005804 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 762051005805 RNA binding surface [nucleotide binding]; other site 762051005806 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 762051005807 active site 762051005808 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 762051005809 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 762051005810 active site 762051005811 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12838 762051005812 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 762051005813 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 762051005814 catalytic site [active] 762051005815 subunit interface [polypeptide binding]; other site 762051005816 Carbamoylphosphate synthase large subunit (split gene in MJ) [Amino acid transport and metabolism / Nucleotide transport and metabolism]; Region: CarB; COG0458 762051005817 ATP-grasp domain; Region: ATP-grasp_4; cl17255 762051005818 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 762051005819 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; smart01096 762051005820 drug efflux system protein MdtG; Provisional; Region: PRK09874 762051005821 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762051005822 putative substrate translocation pore; other site 762051005823 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 762051005824 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 762051005825 Zn2+ binding site [ion binding]; other site 762051005826 Mg2+ binding site [ion binding]; other site 762051005827 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 762051005828 synthetase active site [active] 762051005829 NTP binding site [chemical binding]; other site 762051005830 metal binding site [ion binding]; metal-binding site 762051005831 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 762051005832 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 762051005833 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 762051005834 putative active site [active] 762051005835 dimerization interface [polypeptide binding]; other site 762051005836 putative tRNAtyr binding site [nucleotide binding]; other site 762051005837 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 762051005838 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 762051005839 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762051005840 ATP binding site [chemical binding]; other site 762051005841 Mg2+ binding site [ion binding]; other site 762051005842 G-X-G motif; other site 762051005843 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 762051005844 anchoring element; other site 762051005845 dimer interface [polypeptide binding]; other site 762051005846 ATP binding site [chemical binding]; other site 762051005847 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 762051005848 active site 762051005849 putative metal-binding site [ion binding]; other site 762051005850 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 762051005851 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 762051005852 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 762051005853 CAP-like domain; other site 762051005854 active site 762051005855 primary dimer interface [polypeptide binding]; other site 762051005856 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 762051005857 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 762051005858 DHH family; Region: DHH; pfam01368 762051005859 DHHA2 domain; Region: DHHA2; pfam02833 762051005860 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 762051005861 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 762051005862 ribosome maturation protein RimP; Reviewed; Region: PRK00092 762051005863 Sm and related proteins; Region: Sm_like; cl00259 762051005864 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 762051005865 putative oligomer interface [polypeptide binding]; other site 762051005866 putative RNA binding site [nucleotide binding]; other site 762051005867 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 762051005868 NusA N-terminal domain; Region: NusA_N; pfam08529 762051005869 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 762051005870 RNA binding site [nucleotide binding]; other site 762051005871 homodimer interface [polypeptide binding]; other site 762051005872 NusA-like KH domain; Region: KH_5; pfam13184 762051005873 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 762051005874 G-X-X-G motif; other site 762051005875 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 762051005876 putative RNA binding cleft [nucleotide binding]; other site 762051005877 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 762051005878 translation initiation factor IF-2; Region: IF-2; TIGR00487 762051005879 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 762051005880 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 762051005881 G1 box; other site 762051005882 putative GEF interaction site [polypeptide binding]; other site 762051005883 GTP/Mg2+ binding site [chemical binding]; other site 762051005884 Switch I region; other site 762051005885 G2 box; other site 762051005886 G3 box; other site 762051005887 Switch II region; other site 762051005888 G4 box; other site 762051005889 G5 box; other site 762051005890 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 762051005891 Translation-initiation factor 2; Region: IF-2; pfam11987 762051005892 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 762051005893 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 762051005894 aromatic amino acid aminotransferase; Validated; Region: PRK07309 762051005895 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 762051005896 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762051005897 homodimer interface [polypeptide binding]; other site 762051005898 catalytic residue [active] 762051005899 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 762051005900 HPr interaction site; other site 762051005901 glycerol kinase (GK) interaction site [polypeptide binding]; other site 762051005902 active site 762051005903 phosphorylation site [posttranslational modification] 762051005904 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK02484 762051005905 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 762051005906 RNA binding site [nucleotide binding]; other site 762051005907 active site 762051005908 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 762051005909 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 762051005910 active site 762051005911 Riboflavin kinase; Region: Flavokinase; smart00904 762051005912 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 762051005913 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 762051005914 GrpE; Region: GrpE; pfam01025 762051005915 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 762051005916 dimer interface [polypeptide binding]; other site 762051005917 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 762051005918 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 762051005919 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 762051005920 nucleotide binding site [chemical binding]; other site 762051005921 NEF interaction site [polypeptide binding]; other site 762051005922 SBD interface [polypeptide binding]; other site 762051005923 chaperone protein DnaJ; Provisional; Region: PRK14299 762051005924 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 762051005925 HSP70 interaction site [polypeptide binding]; other site 762051005926 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 762051005927 substrate binding site [polypeptide binding]; other site 762051005928 dimer interface [polypeptide binding]; other site 762051005929 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 762051005930 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 762051005931 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 762051005932 active site 762051005933 catalytic residues [active] 762051005934 metal binding site [ion binding]; metal-binding site 762051005935 Uncharacterized protein family (UPF0223); Region: UPF0223; cl11484 762051005936 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 762051005937 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 762051005938 active site 762051005939 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 762051005940 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 762051005941 G1 box; other site 762051005942 putative GEF interaction site [polypeptide binding]; other site 762051005943 GTP/Mg2+ binding site [chemical binding]; other site 762051005944 Switch I region; other site 762051005945 G2 box; other site 762051005946 G3 box; other site 762051005947 Switch II region; other site 762051005948 G4 box; other site 762051005949 G5 box; other site 762051005950 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 762051005951 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 762051005952 YCII-related domain; Region: YCII; cl00999 762051005953 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 762051005954 conserved cys residue [active] 762051005955 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; cl17626 762051005956 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 762051005957 active site 762051005958 catalytic triad [active] 762051005959 oxyanion hole [active] 762051005960 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 762051005961 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 762051005962 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 762051005963 active site 762051005964 metal binding site [ion binding]; metal-binding site 762051005965 DNA binding site [nucleotide binding] 762051005966 Uncharacterized conserved protein [Function unknown]; Region: COG4717 762051005967 Uncharacterized conserved protein [Function unknown]; Region: COG4717 762051005968 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 762051005969 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 762051005970 generic binding surface II; other site 762051005971 generic binding surface I; other site 762051005972 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 762051005973 Zn2+ binding site [ion binding]; other site 762051005974 Mg2+ binding site [ion binding]; other site 762051005975 peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405 762051005976 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 762051005977 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 762051005978 HIT family signature motif; other site 762051005979 catalytic residue [active] 762051005980 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 762051005981 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 762051005982 Walker A/P-loop; other site 762051005983 ATP binding site [chemical binding]; other site 762051005984 Q-loop/lid; other site 762051005985 ABC transporter signature motif; other site 762051005986 Walker B; other site 762051005987 D-loop; other site 762051005988 H-loop/switch region; other site 762051005989 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 762051005990 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 762051005991 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 762051005992 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 762051005993 CsbD-like; Region: CsbD; pfam05532 762051005994 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 762051005995 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 762051005996 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 762051005997 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 762051005998 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 762051005999 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 762051006000 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 762051006001 active site 762051006002 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 762051006003 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 762051006004 active site 762051006005 metal binding site [ion binding]; metal-binding site 762051006006 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 762051006007 Protein of unknown function (DUF1027); Region: DUF1027; cl09961 762051006008 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 762051006009 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 762051006010 homodimer interface [polypeptide binding]; other site 762051006011 substrate-cofactor binding pocket; other site 762051006012 catalytic residue [active] 762051006013 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 762051006014 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 762051006015 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 762051006016 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 762051006017 NAD binding site [chemical binding]; other site 762051006018 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 762051006019 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 762051006020 putative active site [active] 762051006021 catalytic site [active] 762051006022 putative metal binding site [ion binding]; other site 762051006023 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 762051006024 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 762051006025 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 762051006026 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 762051006027 FMN binding site [chemical binding]; other site 762051006028 active site 762051006029 catalytic residues [active] 762051006030 substrate binding site [chemical binding]; other site 762051006031 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 762051006032 Yqey-like protein; Region: YqeY; pfam09424 762051006033 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 762051006034 S1 domain; Region: S1_2; pfam13509 762051006035 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 762051006036 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 762051006037 active site 762051006038 Int/Topo IB signature motif; other site 762051006039 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 762051006040 segregation and condensation protein B; Reviewed; Region: scpB; PRK00135 762051006041 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 762051006042 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 762051006043 RNA binding surface [nucleotide binding]; other site 762051006044 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 762051006045 active site 762051006046 Predicted membrane protein [Function unknown]; Region: COG3601 762051006047 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 762051006048 cytidylate kinase; Provisional; Region: cmk; PRK00023 762051006049 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 762051006050 CMP-binding site; other site 762051006051 The sites determining sugar specificity; other site 762051006052 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 762051006053 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 762051006054 RNA binding site [nucleotide binding]; other site 762051006055 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 762051006056 RNA binding site [nucleotide binding]; other site 762051006057 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 762051006058 RNA binding site [nucleotide binding]; other site 762051006059 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 762051006060 RNA binding site [nucleotide binding]; other site 762051006061 GTP-binding protein Der; Reviewed; Region: PRK00093 762051006062 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 762051006063 G1 box; other site 762051006064 GTP/Mg2+ binding site [chemical binding]; other site 762051006065 Switch I region; other site 762051006066 G2 box; other site 762051006067 Switch II region; other site 762051006068 G3 box; other site 762051006069 G4 box; other site 762051006070 G5 box; other site 762051006071 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 762051006072 G1 box; other site 762051006073 GTP/Mg2+ binding site [chemical binding]; other site 762051006074 Switch I region; other site 762051006075 G2 box; other site 762051006076 G3 box; other site 762051006077 Switch II region; other site 762051006078 G4 box; other site 762051006079 G5 box; other site 762051006080 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 762051006081 IHF dimer interface [polypeptide binding]; other site 762051006082 IHF - DNA interface [nucleotide binding]; other site 762051006083 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 762051006084 binding surface 762051006085 TPR motif; other site 762051006086 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 762051006087 binding surface 762051006088 TPR motif; other site 762051006089 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 762051006090 binding surface 762051006091 TPR motif; other site 762051006092 TPR repeat; Region: TPR_11; pfam13414 762051006093 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 762051006094 binding surface 762051006095 TPR motif; other site 762051006096 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 762051006097 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 762051006098 active site 762051006099 NTP binding site [chemical binding]; other site 762051006100 metal binding triad [ion binding]; metal-binding site 762051006101 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 762051006102 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 762051006103 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 762051006104 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 762051006105 folate binding site [chemical binding]; other site 762051006106 NADP+ binding site [chemical binding]; other site 762051006107 EDD domain protein, DegV family; Region: DegV; TIGR00762 762051006108 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 762051006109 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 762051006110 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 762051006111 Int/Topo IB signature motif; other site 762051006112 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 762051006113 Domain of unknown function (DUF955); Region: DUF955; cl01076 762051006114 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 762051006115 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 762051006116 non-specific DNA binding site [nucleotide binding]; other site 762051006117 salt bridge; other site 762051006118 sequence-specific DNA binding site [nucleotide binding]; other site 762051006119 Prophage antirepressor [Transcription]; Region: COG3617 762051006120 BRO family, N-terminal domain; Region: Bro-N; smart01040 762051006121 ORF6C domain; Region: ORF6C; pfam10552 762051006122 ORF6N domain; Region: ORF6N; pfam10543 762051006123 ORF6C domain; Region: ORF6C; pfam10552 762051006124 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 762051006125 sequence-specific DNA binding site [nucleotide binding]; other site 762051006126 salt bridge; other site 762051006127 Conserved phage C-terminus (Phg_2220_C); Region: Phg_2220_C; pfam09524 762051006128 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 762051006129 Walker A motif; other site 762051006130 ATP binding site [chemical binding]; other site 762051006131 Walker B motif; other site 762051006132 arginine finger; other site 762051006133 ERF superfamily; Region: ERF; pfam04404 762051006134 Protein of unknown function (DUF968); Region: DUF968; pfam06147 762051006135 Endodeoxyribonuclease RusA; Region: RusA; cl01885 762051006136 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 762051006137 Protein of unknown function (DUF722); Region: DUF722; pfam05263 762051006138 MTH538 TIR-like domain (DUF1863); Region: DUF1863; pfam08937 762051006139 Winged helix-turn helix; Region: HTH_29; pfam13551 762051006140 Terminase small subunit; Region: Terminase_2; pfam03592 762051006141 Phage terminase large subunit; Region: Terminase_3; cl12054 762051006142 Terminase-like family; Region: Terminase_6; pfam03237 762051006143 phage portal protein, putative, A118 family; Region: A118_put_portal; TIGR01542 762051006144 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 762051006145 Phage minor capsid protein 2; Region: Phage_min_cap2; pfam06152 762051006146 Phage minor structural protein GP20; Region: Phage_GP20; pfam06810 762051006147 Phage capsid family; Region: Phage_capsid; pfam05065 762051006148 Minor capsid protein; Region: Minor_capsid_1; pfam10665 762051006149 Minor capsid protein; Region: Minor_capsid_2; pfam11114 762051006150 Minor capsid protein from bacteriophage; Region: Minor_capsid_3; pfam12691 762051006151 Bacteriophage Gp15 protein; Region: Phage_Gp15; pfam06854 762051006152 tape measure domain; Region: tape_meas_nterm; TIGR02675 762051006153 membrane protein P6; Region: PHA01399 762051006154 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 762051006155 NlpC/P60 family; Region: NLPC_P60; pfam00877 762051006156 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 762051006157 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 762051006158 N-acetyl-D-glucosamine binding site [chemical binding]; other site 762051006159 catalytic residue [active] 762051006160 Phage tail protein; Region: Sipho_tail; pfam05709 762051006161 Prophage endopeptidase tail; Region: Prophage_tail; pfam06605 762051006162 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 762051006163 active site 762051006164 oxyanion hole [active] 762051006165 catalytic triad [active] 762051006166 Protein of unknown function (DUF972); Region: DUF972; pfam06156 762051006167 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 762051006168 amidase catalytic site [active] 762051006169 Zn binding residues [ion binding]; other site 762051006170 substrate binding site [chemical binding]; other site 762051006171 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 762051006172 NH_3: A subgroup of nucleoside hydrolases. This group contains eukaryotic and bacterial proteins similar to nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes...; Region: nuc_hydro_3; cd02653 762051006173 active site 762051006174 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 762051006175 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 762051006176 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 762051006177 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 762051006178 TPP-binding site [chemical binding]; other site 762051006179 dimer interface [polypeptide binding]; other site 762051006180 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 762051006181 PYR/PP interface [polypeptide binding]; other site 762051006182 dimer interface [polypeptide binding]; other site 762051006183 TPP binding site [chemical binding]; other site 762051006184 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 762051006185 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 762051006186 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 762051006187 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 762051006188 shikimate binding site; other site 762051006189 NAD(P) binding site [chemical binding]; other site 762051006190 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 762051006191 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; cl17225 762051006192 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 762051006193 active site 762051006194 dimer interface [polypeptide binding]; other site 762051006195 metal binding site [ion binding]; metal-binding site 762051006196 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 762051006197 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 762051006198 Tetramer interface [polypeptide binding]; other site 762051006199 active site 762051006200 FMN-binding site [chemical binding]; other site 762051006201 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 762051006202 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 762051006203 hinge; other site 762051006204 active site 762051006205 prephenate dehydrogenase; Validated; Region: PRK08507 762051006206 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 762051006207 shikimate kinase; Reviewed; Region: aroK; PRK00131 762051006208 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 762051006209 ADP binding site [chemical binding]; other site 762051006210 magnesium binding site [ion binding]; other site 762051006211 putative shikimate binding site; other site 762051006212 Chorismate mutase type II; Region: CM_2; smart00830 762051006213 Prephenate dehydratase; Region: PDT; pfam00800 762051006214 Sulfatase; Region: Sulfatase; cl17466 762051006215 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 762051006216 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 762051006217 active site 762051006218 catalytic residue [active] 762051006219 dimer interface [polypeptide binding]; other site 762051006220 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 762051006221 DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587 762051006222 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 762051006223 active site 762051006224 PHP Thumb interface [polypeptide binding]; other site 762051006225 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 762051006226 generic binding surface II; other site 762051006227 generic binding surface I; other site 762051006228 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 762051006229 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 762051006230 domain interfaces; other site 762051006231 active site 762051006232 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 762051006233 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 762051006234 PhoH-like protein; Region: PhoH; pfam02562 762051006235 metal-binding heat shock protein; Provisional; Region: PRK00016 762051006236 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219 762051006237 GTPase Era; Reviewed; Region: era; PRK00089 762051006238 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 762051006239 G1 box; other site 762051006240 GTP/Mg2+ binding site [chemical binding]; other site 762051006241 Switch I region; other site 762051006242 G2 box; other site 762051006243 Switch II region; other site 762051006244 G3 box; other site 762051006245 G4 box; other site 762051006246 G5 box; other site 762051006247 KH domain; Region: KH_2; pfam07650 762051006248 DNA repair protein RecO; Region: reco; TIGR00613 762051006249 Recombination protein O N terminal; Region: RecO_N; pfam11967 762051006250 Recombination protein O C terminal; Region: RecO_C; pfam02565 762051006251 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 762051006252 active site 762051006253 homotetramer interface [polypeptide binding]; other site 762051006254 homodimer interface [polypeptide binding]; other site 762051006255 aspartate kinase; Reviewed; Region: PRK09034 762051006256 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 762051006257 putative catalytic residues [active] 762051006258 putative nucleotide binding site [chemical binding]; other site 762051006259 putative aspartate binding site [chemical binding]; other site 762051006260 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 762051006261 allosteric regulatory residue; other site 762051006262 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 762051006263 homoserine kinase; Provisional; Region: PRK01212 762051006264 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 762051006265 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 762051006266 homoserine dehydrogenase; Provisional; Region: PRK06349 762051006267 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 762051006268 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 762051006269 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 762051006270 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 762051006271 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 762051006272 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762051006273 catalytic residue [active] 762051006274 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 762051006275 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 762051006276 dimer interface [polypeptide binding]; other site 762051006277 active site 762051006278 glycine-pyridoxal phosphate binding site [chemical binding]; other site 762051006279 folate binding site [chemical binding]; other site 762051006280 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 762051006281 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 762051006282 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 762051006283 Bacterial SH3 domain; Region: SH3_3; pfam08239 762051006284 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 762051006285 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 762051006286 active site 762051006287 metal binding site [ion binding]; metal-binding site 762051006288 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 762051006289 propionate/acetate kinase; Provisional; Region: PRK12379 762051006290 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 762051006291 Dihydroorotate dehydrogenase (DHOD) class 1A FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1A_like; cd04741 762051006292 active site 762051006293 FMN binding site [chemical binding]; other site 762051006294 substrate binding site [chemical binding]; other site 762051006295 catalytic residues [active] 762051006296 homodimer interface [polypeptide binding]; other site 762051006297 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 762051006298 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 762051006299 Walker A/P-loop; other site 762051006300 ATP binding site [chemical binding]; other site 762051006301 Q-loop/lid; other site 762051006302 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 762051006303 ABC transporter signature motif; other site 762051006304 Walker B; other site 762051006305 D-loop; other site 762051006306 ABC transporter; Region: ABC_tran_2; pfam12848 762051006307 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 762051006308 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 762051006309 DNA protecting protein DprA; Region: dprA; TIGR00732 762051006310 PTS system fructose IIA component; Region: EIIA-man; pfam03610 762051006311 active pocket/dimerization site; other site 762051006312 active site 762051006313 phosphorylation site [posttranslational modification] 762051006314 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cl00021 762051006315 active site 762051006316 phosphorylation site [posttranslational modification] 762051006317 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 762051006318 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 762051006319 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 762051006320 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 762051006321 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 762051006322 Glycosyl hydrolase family 70; Region: Glyco_hydro_70; pfam02324 762051006323 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 762051006324 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 762051006325 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 762051006326 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 762051006327 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 762051006328 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 762051006329 Transcriptional regulators [Transcription]; Region: PurR; COG1609 762051006330 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 762051006331 DNA binding site [nucleotide binding] 762051006332 domain linker motif; other site 762051006333 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 762051006334 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 762051006335 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762051006336 putative substrate translocation pore; other site 762051006337 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 762051006338 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 762051006339 Ca binding site [ion binding]; other site 762051006340 active site 762051006341 catalytic site [active] 762051006342 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 762051006343 potential frameshift: common BLAST hit: gi|116617932|ref|YP_818303.1| 5-amino-6-(5-phosphoribosylamino)uracil reductase / 762051006344 Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes. All members...; Region: cytidine_deaminase-like; cl00269 762051006345 active site 762051006346 Zn binding site [ion binding]; other site 762051006347 Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes. All members...; Region: cytidine_deaminase-like; cl00269 762051006348 RibD C-terminal domain; Region: RibD_C; cl17279 762051006349 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 762051006350 Lumazine binding domain; Region: Lum_binding; pfam00677 762051006351 Lumazine binding domain; Region: Lum_binding; pfam00677 762051006352 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 762051006353 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 762051006354 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 762051006355 dimerization interface [polypeptide binding]; other site 762051006356 active site 762051006357 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 762051006358 homopentamer interface [polypeptide binding]; other site 762051006359 active site 762051006360 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762051006361 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762051006362 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762051006363 dimerization interface [polypeptide binding]; other site 762051006364 malate dehydrogenase; Provisional; Region: PRK13529 762051006365 Malic enzyme, N-terminal domain; Region: malic; pfam00390 762051006366 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 762051006367 NAD(P) binding site [chemical binding]; other site 762051006368 2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390 762051006369 potential frameshift: common BLAST hit: gi|116493838|ref|YP_805572.1| 4-methyl-5(B-hydroxyethyl)-thiazole monophosphate biosynthesis 762051006370 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 762051006371 conserved cys residue [active] 762051006372 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 762051006373 DNA primase; Validated; Region: dnaG; PRK05667 762051006374 CHC2 zinc finger; Region: zf-CHC2; pfam01807 762051006375 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 762051006376 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 762051006377 active site 762051006378 metal binding site [ion binding]; metal-binding site 762051006379 interdomain interaction site; other site 762051006380 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 762051006381 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 762051006382 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 762051006383 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 762051006384 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 762051006385 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 762051006386 DNA binding residues [nucleotide binding] 762051006387 QueT transporter; Region: QueT; pfam06177 762051006388 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK06550 762051006389 classical (c) SDRs; Region: SDR_c; cd05233 762051006390 NAD(P) binding site [chemical binding]; other site 762051006391 active site 762051006392 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033 762051006393 putative uracil binding site [chemical binding]; other site 762051006394 putative active site [active] 762051006395 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 762051006396 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 762051006397 putative NAD(P) binding site [chemical binding]; other site 762051006398 catalytic Zn binding site [ion binding]; other site 762051006399 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 762051006400 catalytic residues [active] 762051006401 dimer interface [polypeptide binding]; other site 762051006402 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 762051006403 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 762051006404 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 762051006405 active site 762051006406 catalytic tetrad [active] 762051006407 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 762051006408 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 762051006409 Walker A/P-loop; other site 762051006410 ATP binding site [chemical binding]; other site 762051006411 Q-loop/lid; other site 762051006412 ABC transporter signature motif; other site 762051006413 Walker B; other site 762051006414 D-loop; other site 762051006415 H-loop/switch region; other site 762051006416 TOBE domain; Region: TOBE_2; pfam08402 762051006417 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762051006418 dimer interface [polypeptide binding]; other site 762051006419 conserved gate region; other site 762051006420 putative PBP binding loops; other site 762051006421 ABC-ATPase subunit interface; other site 762051006422 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 762051006423 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762051006424 dimer interface [polypeptide binding]; other site 762051006425 conserved gate region; other site 762051006426 putative PBP binding loops; other site 762051006427 ABC-ATPase subunit interface; other site 762051006428 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 762051006429 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 762051006430 Transposase IS200 like; Region: Y1_Tnp; pfam01797 762051006431 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 762051006432 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 762051006433 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 762051006434 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 762051006435 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 762051006436 motif II; other site 762051006437 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 762051006438 Enterocin A Immunity; Region: EntA_Immun; pfam08951 762051006439 Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225 762051006440 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 762051006441 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 762051006442 putative active site [active] 762051006443 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 762051006444 Helix-turn-helix domain; Region: HTH_38; pfam13936 762051006445 Integrase core domain; Region: rve; pfam00665