-- dump date 20140619_131722 -- class Genbank::misc_feature -- table misc_feature_note -- id note 349519000001 Restriction endonuclease [Defense mechanisms]; Region: Mrr; COG1715 349519000002 Mrr N-terminal domain; Region: Mrr_N; pfam14338 349519000003 Restriction endonuclease; Region: Mrr_cat; pfam04471 349519000004 Plasmid recombination enzyme; Region: Mob_Pre; pfam01076 349519000005 Plasmid recombination enzyme; Region: Mob_Pre; pfam01076 349519000006 Integrase core domain; Region: rve_3; cl15866 349519000007 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 349519000008 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 349519000009 P-loop; other site 349519000010 Magnesium ion binding site [ion binding]; other site 349519000011 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 349519000012 Magnesium ion binding site [ion binding]; other site 349519000013 Transposase; Region: HTH_Tnp_1; cl17663 349519000014 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 349519000015 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 349519000016 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 349519000017 putative substrate translocation pore; other site 349519000018 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 349519000019 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 349519000020 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 349519000021 active site 349519000022 catalytic tetrad [active] 349519000023 Predicted membrane protein [Function unknown]; Region: COG2261 349519000024 Protein of unknown function (DUF1345); Region: DUF1345; pfam07077 349519000025 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 349519000026 Small integral membrane protein (DUF2273); Region: DUF2273; pfam10031 349519000027 Predicted membrane protein [Function unknown]; Region: COG2261 349519000028 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 349519000029 active site 349519000030 Integrase core domain; Region: rve; pfam00665 349519000031 Integrase core domain; Region: rve_2; pfam13333 349519000032 HTH-like domain; Region: HTH_21; pfam13276 349519000033 Integrase core domain; Region: rve; pfam00665 349519000034 Integrase core domain; Region: rve_3; pfam13683 349519000035 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 349519000036 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 349519000037 Major Facilitator Superfamily; Region: MFS_1; pfam07690 349519000038 putative substrate translocation pore; other site 349519000039 maltose phosphorylase; Provisional; Region: PRK13807 349519000040 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 349519000041 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 349519000042 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 349519000043 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 349519000044 active site 349519000045 catalytic residues [active] 349519000046 beta-phosphoglucomutase; Region: bPGM; TIGR01990 349519000047 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 349519000048 motif II; other site 349519000049 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 349519000050 active site 349519000051 DNA binding site [nucleotide binding] 349519000052 Int/Topo IB signature motif; other site 349519000053 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 349519000054 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 349519000055 ligand binding site [chemical binding]; other site 349519000056 flexible hinge region; other site 349519000057 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 349519000058 putative switch regulator; other site 349519000059 non-specific DNA interactions [nucleotide binding]; other site 349519000060 DNA binding site [nucleotide binding] 349519000061 sequence specific DNA binding site [nucleotide binding]; other site 349519000062 putative cAMP binding site [chemical binding]; other site 349519000063 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 349519000064 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 349519000065 dimerization interface [polypeptide binding]; other site 349519000066 DPS ferroxidase diiron center [ion binding]; other site 349519000067 ion pore; other site 349519000068 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 349519000069 metal-binding site [ion binding] 349519000070 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 349519000071 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 349519000072 Soluble P-type ATPase [General function prediction only]; Region: COG4087 349519000073 multicopper oxidase; Provisional; Region: PRK10965 349519000074 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 349519000075 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 349519000076 Integrase core domain; Region: rve; pfam00665 349519000077 Integrase core domain; Region: rve_2; pfam13333 349519000078 Protein involved in initiation of plasmid replication [DNA replication, recombination, and repair]; Region: COG5527 349519000079 Initiator Replication protein; Region: Rep_3; pfam01051 349519000080 Lactococcus lactis RepB C-terminus; Region: L_lactis_RepB_C; pfam06430 349519000081 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 349519000082 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 349519000083 DNA-binding interface [nucleotide binding]; DNA binding site 349519000084 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 349519000085 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 349519000086 non-specific DNA binding site [nucleotide binding]; other site 349519000087 salt bridge; other site 349519000088 sequence-specific DNA binding site [nucleotide binding]; other site 349519000089 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 349519000090 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 349519000091 non-specific DNA binding site [nucleotide binding]; other site 349519000092 salt bridge; other site 349519000093 sequence-specific DNA binding site [nucleotide binding]; other site 349519000094 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 349519000095 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 349519000096 sequence-specific DNA binding site [nucleotide binding]; other site 349519000097 salt bridge; other site 349519000098 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 349519000099 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 349519000100 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 349519000101 catalytic residues [active] 349519000102 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 349519000103 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 349519000104 catalytic residues [active] 349519000105 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 349519000106 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 349519000107 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 349519000108 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 349519000109 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 349519000110 catalytic residues [active] 349519000111 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 349519000112 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 349519000113 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 349519000114 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 349519000115 dimerization interface [polypeptide binding]; other site 349519000116 putative DNA binding site [nucleotide binding]; other site 349519000117 putative Zn2+ binding site [ion binding]; other site 349519000118 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 349519000119 active site residue [active] 349519000120 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 349519000121 catalytic residues [active] 349519000122 multiple promoter invertase; Provisional; Region: mpi; PRK13413 349519000123 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 349519000124 catalytic residues [active] 349519000125 catalytic nucleophile [active] 349519000126 Presynaptic Site I dimer interface [polypeptide binding]; other site 349519000127 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 349519000128 Synaptic Flat tetramer interface [polypeptide binding]; other site 349519000129 Synaptic Site I dimer interface [polypeptide binding]; other site 349519000130 DNA binding site [nucleotide binding] 349519000131 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 349519000132 DNA-binding interface [nucleotide binding]; DNA binding site 349519000133 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 349519000134 HTH-like domain; Region: HTH_21; pfam13276 349519000135 Integrase core domain; Region: rve; pfam00665 349519000136 Integrase core domain; Region: rve_3; cl15866 349519000137 Transposase; Region: HTH_Tnp_1; pfam01527 349519000138 Plasmid recombination enzyme; Region: Mob_Pre; pfam01076 349519000139 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 349519000140 active site 349519000141 DNA binding site [nucleotide binding] 349519000142 Int/Topo IB signature motif; other site 349519000143 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 349519000144 Coenzyme A binding pocket [chemical binding]; other site 349519000145 Plasmid recombination enzyme; Region: Mob_Pre; pfam01076 349519000146 Protein involved in initiation of plasmid replication [DNA replication, recombination, and repair]; Region: COG5527 349519000147 Initiator Replication protein; Region: Rep_3; pfam01051 349519000148 Lactococcus lactis RepB C-terminus; Region: L_lactis_RepB_C; pfam06430 349519000149 HTH DNA binding domain; Region: HTH_10; pfam04967 349519000150 Transposase; Region: HTH_Tnp_1; pfam01527 349519000151 copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698 349519000152 Penicillinase repressor; Region: Pencillinase_R; pfam03965 349519000153 Copper resistance protein B precursor (CopB); Region: CopB; cl01476 349519000154 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 349519000155 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 349519000156 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 349519000157 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619 349519000158 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 349519000159 Walker A/P-loop; other site 349519000160 ATP binding site [chemical binding]; other site 349519000161 Q-loop/lid; other site 349519000162 ABC transporter signature motif; other site 349519000163 Walker B; other site 349519000164 D-loop; other site 349519000165 H-loop/switch region; other site 349519000166 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 349519000167 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 349519000168 Special lobe-specific silk protein SSP160; Region: SSP160; pfam06933 349519000169 MarR family; Region: MarR; pfam01047 349519000170 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 349519000171 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 349519000172 catalytic residues [active] 349519000173 catalytic nucleophile [active] 349519000174 Presynaptic Site I dimer interface [polypeptide binding]; other site 349519000175 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 349519000176 Synaptic Flat tetramer interface [polypeptide binding]; other site 349519000177 Synaptic Site I dimer interface [polypeptide binding]; other site 349519000178 DNA binding site [nucleotide binding] 349519000179 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 349519000180 Transposase; Region: HTH_Tnp_1; pfam01527 349519000181 Integrase core domain; Region: rve; pfam00665 349519000182 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 349519000183 catalytic nucleophile [active] 349519000184 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cd00004 349519000185 active site 349519000186 catalytic site [active] 349519000187 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 349519000188 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 349519000189 catalytic residues [active] 349519000190 Transposase; Region: HTH_Tnp_1; cl17663 349519000191 Integrase core domain; Region: rve_3; cl15866 349519000192 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 349519000193 Low molecular weight phosphatase family; Region: LMWPc; cd00115 349519000194 active site 349519000195 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 349519000196 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 349519000197 P-loop; other site 349519000198 Magnesium ion binding site [ion binding]; other site 349519000199 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 349519000200 Magnesium ion binding site [ion binding]; other site 349519000201 Domain of unknown function (DUF955); Region: DUF955; pfam06114 349519000202 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 349519000203 non-specific DNA binding site [nucleotide binding]; other site 349519000204 salt bridge; other site 349519000205 sequence-specific DNA binding site [nucleotide binding]; other site 349519000206 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 349519000207 Replication initiation factor; Region: Rep_trans; pfam02486 349519000208 Conjugative transposon protein TcpC; Region: TpcC; pfam12642 349519000209 TcpE family; Region: TcpE; pfam12648 349519000210 Antirestriction protein (ArdA); Region: ArdA; cl01953 349519000211 AAA-like domain; Region: AAA_10; pfam12846 349519000212 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; pfam04610 349519000213 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 349519000214 catalytic residues [active] 349519000215 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 349519000216 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 349519000217 Integrase core domain; Region: rve; pfam00665 349519000218 Integrase core domain; Region: rve_2; pfam13333 349519000219 Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes. All members...; Region: cytidine_deaminase-like; cl00269 349519000220 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 349519000221 active site 349519000222 NTP binding site [chemical binding]; other site 349519000223 metal binding triad [ion binding]; metal-binding site 349519000224 antibiotic binding site [chemical binding]; other site 349519000225 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 349519000226 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 349519000227 DnaA N-terminal domain; Region: DnaA_N; pfam11638 349519000228 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 349519000229 Walker A motif; other site 349519000230 ATP binding site [chemical binding]; other site 349519000231 Walker B motif; other site 349519000232 arginine finger; other site 349519000233 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 349519000234 DnaA box-binding interface [nucleotide binding]; other site 349519000235 DNA polymerase III subunit beta; Validated; Region: PRK05643 349519000236 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 349519000237 putative DNA binding surface [nucleotide binding]; other site 349519000238 dimer interface [polypeptide binding]; other site 349519000239 beta-clamp/clamp loader binding surface; other site 349519000240 beta-clamp/translesion DNA polymerase binding surface; other site 349519000241 S4 domain; Region: S4_2; pfam13275 349519000242 recombination protein F; Reviewed; Region: recF; PRK00064 349519000243 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 349519000244 Walker A/P-loop; other site 349519000245 ATP binding site [chemical binding]; other site 349519000246 Q-loop/lid; other site 349519000247 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 349519000248 ABC transporter signature motif; other site 349519000249 Walker B; other site 349519000250 D-loop; other site 349519000251 H-loop/switch region; other site 349519000252 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 349519000253 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 349519000254 Mg2+ binding site [ion binding]; other site 349519000255 G-X-G motif; other site 349519000256 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 349519000257 anchoring element; other site 349519000258 dimer interface [polypeptide binding]; other site 349519000259 ATP binding site [chemical binding]; other site 349519000260 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 349519000261 active site 349519000262 putative metal-binding site [ion binding]; other site 349519000263 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 349519000264 DNA gyrase subunit A; Validated; Region: PRK05560 349519000265 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 349519000266 CAP-like domain; other site 349519000267 active site 349519000268 primary dimer interface [polypeptide binding]; other site 349519000269 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 349519000270 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 349519000271 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 349519000272 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 349519000273 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 349519000274 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 349519000275 PspC domain; Region: PspC; pfam04024 349519000276 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 349519000277 Predicted transcriptional regulators [Transcription]; Region: COG1695 349519000278 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 349519000279 HlyD family secretion protein; Region: HlyD_2; pfam12700 349519000280 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 349519000281 HlyD family secretion protein; Region: HlyD_3; pfam13437 349519000282 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 349519000283 Walker A/P-loop; other site 349519000284 ATP binding site [chemical binding]; other site 349519000285 ABC transporter; Region: ABC_tran; pfam00005 349519000286 Q-loop/lid; other site 349519000287 ABC transporter signature motif; other site 349519000288 Walker B; other site 349519000289 D-loop; other site 349519000290 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 349519000291 FtsX-like permease family; Region: FtsX; pfam02687 349519000292 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 349519000293 Walker A/P-loop; other site 349519000294 ATP binding site [chemical binding]; other site 349519000295 Q-loop/lid; other site 349519000296 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 349519000297 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 349519000298 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 349519000299 Walker A/P-loop; other site 349519000300 ATP binding site [chemical binding]; other site 349519000301 Q-loop/lid; other site 349519000302 ABC transporter signature motif; other site 349519000303 Walker B; other site 349519000304 D-loop; other site 349519000305 H-loop/switch region; other site 349519000306 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 349519000307 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 349519000308 non-specific DNA binding site [nucleotide binding]; other site 349519000309 salt bridge; other site 349519000310 sequence-specific DNA binding site [nucleotide binding]; other site 349519000311 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 349519000312 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 349519000313 putative substrate translocation pore; other site 349519000314 Major Facilitator Superfamily; Region: MFS_1; pfam07690 349519000315 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 349519000316 MarR family; Region: MarR_2; pfam12802 349519000317 CAAX protease self-immunity; Region: Abi; pfam02517 349519000318 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 349519000319 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 349519000320 salt bridge; other site 349519000321 non-specific DNA binding site [nucleotide binding]; other site 349519000322 sequence-specific DNA binding site [nucleotide binding]; other site 349519000323 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 349519000324 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 349519000325 Walker A/P-loop; other site 349519000326 ATP binding site [chemical binding]; other site 349519000327 Q-loop/lid; other site 349519000328 ABC transporter signature motif; other site 349519000329 Walker B; other site 349519000330 D-loop; other site 349519000331 H-loop/switch region; other site 349519000332 Protein of unknown function (DUF975); Region: DUF975; cl10504 349519000333 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 349519000334 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 349519000335 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 349519000336 non-specific DNA binding site [nucleotide binding]; other site 349519000337 salt bridge; other site 349519000338 sequence-specific DNA binding site [nucleotide binding]; other site 349519000339 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 349519000340 tyrosyl-tRNA synthetase; Provisional; Region: PRK13354 349519000341 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 349519000342 active site 349519000343 HIGH motif; other site 349519000344 dimer interface [polypeptide binding]; other site 349519000345 KMSKS motif; other site 349519000346 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 349519000347 RNA binding surface [nucleotide binding]; other site 349519000348 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 349519000349 D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186 349519000350 homodimer interface [polypeptide binding]; other site 349519000351 ligand binding site [chemical binding]; other site 349519000352 NAD binding site [chemical binding]; other site 349519000353 catalytic site [active] 349519000354 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 349519000355 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 349519000356 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352 349519000357 Transposase; Region: HTH_Tnp_1; cl17663 349519000358 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 349519000359 HTH-like domain; Region: HTH_21; pfam13276 349519000360 Integrase core domain; Region: rve; pfam00665 349519000361 Integrase core domain; Region: rve_2; pfam13333 349519000362 sensory histidine kinase DcuS; Provisional; Region: PRK11086 349519000363 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 349519000364 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 349519000365 active site 349519000366 phosphorylation site [posttranslational modification] 349519000367 intermolecular recognition site; other site 349519000368 dimerization interface [polypeptide binding]; other site 349519000369 LytTr DNA-binding domain; Region: LytTR; smart00850 349519000370 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 349519000371 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 349519000372 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 349519000373 active site 349519000374 motif I; other site 349519000375 motif II; other site 349519000376 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 349519000377 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 349519000378 Protein of unknown function (DUF1440); Region: DUF1440; pfam07274 349519000379 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 349519000380 DNA-binding site [nucleotide binding]; DNA binding site 349519000381 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 349519000382 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 349519000383 Walker A/P-loop; other site 349519000384 ATP binding site [chemical binding]; other site 349519000385 Q-loop/lid; other site 349519000386 ABC transporter signature motif; other site 349519000387 Walker B; other site 349519000388 D-loop; other site 349519000389 H-loop/switch region; other site 349519000390 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 349519000391 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 349519000392 Walker A/P-loop; other site 349519000393 ATP binding site [chemical binding]; other site 349519000394 Q-loop/lid; other site 349519000395 ABC transporter signature motif; other site 349519000396 Walker B; other site 349519000397 D-loop; other site 349519000398 H-loop/switch region; other site 349519000399 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 349519000400 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 349519000401 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 349519000402 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 349519000403 active site 349519000404 catalytic tetrad [active] 349519000405 Metal binding protein TroA_b. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: TroA_b; cd01020 349519000406 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 349519000407 metal binding site [ion binding]; metal-binding site 349519000408 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 349519000409 MarR family; Region: MarR; pfam01047 349519000410 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 349519000411 ABC-type transport system involved in cytochrome c biogenesis, ATPase component [Posttranslational modification, protein turnover, chaperones]; Region: CcmA; COG4133 349519000412 Walker A/P-loop; other site 349519000413 ATP binding site [chemical binding]; other site 349519000414 Q-loop/lid; other site 349519000415 ABC transporter signature motif; other site 349519000416 Walker B; other site 349519000417 D-loop; other site 349519000418 H-loop/switch region; other site 349519000419 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 349519000420 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 349519000421 active site 349519000422 metal binding site [ion binding]; metal-binding site 349519000423 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 349519000424 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 349519000425 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 349519000426 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 349519000427 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 349519000428 Putative esterase; Region: Esterase; pfam00756 349519000429 S-formylglutathione hydrolase; Region: PLN02442 349519000430 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947 349519000431 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 349519000432 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 349519000433 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 349519000434 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 349519000435 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 349519000436 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 349519000437 Transcriptional regulators [Transcription]; Region: PurR; COG1609 349519000438 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 349519000439 DNA binding site [nucleotide binding] 349519000440 domain linker motif; other site 349519000441 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 349519000442 dimerization interface [polypeptide binding]; other site 349519000443 ligand binding site [chemical binding]; other site 349519000444 sodium binding site [ion binding]; other site 349519000445 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 349519000446 Major Facilitator Superfamily; Region: MFS_1; pfam07690 349519000447 putative substrate translocation pore; other site 349519000448 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 349519000449 Predicted membrane protein [Function unknown]; Region: COG2855 349519000450 Transcriptional regulator [Transcription]; Region: LysR; COG0583 349519000451 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 349519000452 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 349519000453 dimerization interface [polypeptide binding]; other site 349519000454 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 349519000455 non-specific DNA binding site [nucleotide binding]; other site 349519000456 salt bridge; other site 349519000457 sequence-specific DNA binding site [nucleotide binding]; other site 349519000458 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 349519000459 catalytic core [active] 349519000460 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 349519000461 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 349519000462 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 349519000463 ATP binding site [chemical binding]; other site 349519000464 putative Mg++ binding site [ion binding]; other site 349519000465 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 349519000466 nucleotide binding region [chemical binding]; other site 349519000467 ATP-binding site [chemical binding]; other site 349519000468 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 349519000469 HRDC domain; Region: HRDC; pfam00570 349519000470 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 349519000471 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 349519000472 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 349519000473 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 349519000474 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 349519000475 inhibitor binding site; inhibition site 349519000476 active site 349519000477 WIF domain; Region: WIF; cl02623 349519000478 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 349519000479 active site 349519000480 catalytic residues [active] 349519000481 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 349519000482 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 349519000483 nucleotide binding site [chemical binding]; other site 349519000484 xylose isomerase; Provisional; Region: PRK05474 349519000485 xylose isomerase; Region: xylose_isom_A; TIGR02630 349519000486 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 349519000487 N- and C-terminal domain interface [polypeptide binding]; other site 349519000488 D-xylulose kinase; Region: XylB; TIGR01312 349519000489 active site 349519000490 MgATP binding site [chemical binding]; other site 349519000491 catalytic site [active] 349519000492 metal binding site [ion binding]; metal-binding site 349519000493 xylulose binding site [chemical binding]; other site 349519000494 homodimer interface [polypeptide binding]; other site 349519000495 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 349519000496 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 349519000497 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 349519000498 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 349519000499 Low molecular weight phosphatase family; Region: LMWPc; cd00115 349519000500 active site 349519000501 YCII-related domain; Region: YCII; cl00999 349519000502 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 349519000503 Domain of unknown function (DUF955); Region: DUF955; cl01076 349519000504 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 349519000505 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 349519000506 non-specific DNA binding site [nucleotide binding]; other site 349519000507 salt bridge; other site 349519000508 sequence-specific DNA binding site [nucleotide binding]; other site 349519000509 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 349519000510 nucleotide binding site [chemical binding]; other site 349519000511 polymerase nucleotide-binding site; other site 349519000512 primase nucleotide-binding site [nucleotide binding]; other site 349519000513 DNA-binding residues [nucleotide binding]; DNA binding site 349519000514 Primase C terminal 1 (PriCT-1); Region: PriCT_1; smart00942 349519000515 D5 N terminal like; Region: D5_N; pfam08706 349519000516 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 349519000517 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 349519000518 HTH-like domain; Region: HTH_21; pfam13276 349519000519 Integrase core domain; Region: rve; pfam00665 349519000520 Integrase core domain; Region: rve_2; pfam13333 349519000521 Transposase; Region: HTH_Tnp_1; cl17663 349519000522 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 349519000523 DNA binding site [nucleotide binding] 349519000524 active site 349519000525 Int/Topo IB signature motif; other site 349519000526 DsrE/DsrF-like family; Region: DrsE; cl00672 349519000527 benzoate transport; Region: 2A0115; TIGR00895 349519000528 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 349519000529 putative substrate translocation pore; other site 349519000530 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 349519000531 nudix motif; other site 349519000532 Protein of unknown function (DUF805); Region: DUF805; pfam05656 349519000533 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 349519000534 acetoin reductase; Validated; Region: PRK08643 349519000535 NAD(P) binding site [chemical binding]; other site 349519000536 active site 349519000537 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 349519000538 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 349519000539 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 349519000540 Malic enzyme, N-terminal domain; Region: malic; pfam00390 349519000541 Malic enzyme, NAD binding domain; Region: Malic_M; smart00919 349519000542 NAD(P) binding pocket [chemical binding]; other site 349519000543 [citrate (pro-3S)-lyase] ligase; Region: cit_ly_ligase; TIGR00124 349519000544 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 349519000545 active site 349519000546 nucleotide binding site [chemical binding]; other site 349519000547 HIGH motif; other site 349519000548 KMSKS motif; other site 349519000549 citrate lyase subunit gamma; Provisional; Region: PRK13253 349519000550 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 349519000551 Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051 349519000552 Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase; Region: CitX; pfam03802 349519000553 ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; cl00768 349519000554 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 349519000555 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 349519000556 nucleophilic elbow; other site 349519000557 catalytic triad; other site 349519000558 2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390 349519000559 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 349519000560 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 349519000561 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 349519000562 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 349519000563 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 349519000564 Walker A/P-loop; other site 349519000565 ATP binding site [chemical binding]; other site 349519000566 Q-loop/lid; other site 349519000567 ABC transporter signature motif; other site 349519000568 Walker B; other site 349519000569 D-loop; other site 349519000570 H-loop/switch region; other site 349519000571 TOBE domain; Region: TOBE_2; pfam08402 349519000572 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 349519000573 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 349519000574 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 349519000575 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 349519000576 dimer interface [polypeptide binding]; other site 349519000577 conserved gate region; other site 349519000578 putative PBP binding loops; other site 349519000579 ABC-ATPase subunit interface; other site 349519000580 Glycerophosphodiester phosphodiesterase domain of Agrobacterium tumefaciens and similar proteins; Region: GDPD_AtGDE_like; cd08566 349519000581 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 349519000582 putative active site [active] 349519000583 catalytic site [active] 349519000584 putative metal binding site [ion binding]; other site 349519000585 oligomer interface [polypeptide binding]; other site 349519000586 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 349519000587 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 349519000588 putative catalytic cysteine [active] 349519000589 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 349519000590 putative active site [active] 349519000591 metal binding site [ion binding]; metal-binding site 349519000592 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 349519000593 Predicted membrane protein [Function unknown]; Region: COG1511 349519000594 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 349519000595 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 349519000596 Predicted transcriptional regulator [Transcription]; Region: COG1959 349519000597 Transcriptional regulator; Region: Rrf2; pfam02082 349519000598 Transcriptional regulator; Region: Rrf2; cl17282 349519000599 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 349519000600 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 349519000601 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 349519000602 DNA-binding interface [nucleotide binding]; DNA binding site 349519000603 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 349519000604 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 349519000605 putative substrate translocation pore; other site 349519000606 Major Facilitator Superfamily; Region: MFS_1; pfam07690 349519000607 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 349519000608 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 349519000609 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 349519000610 nucleotide binding site [chemical binding]; other site 349519000611 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 349519000612 beta-galactosidase; Region: BGL; TIGR03356 349519000613 transcriptional antiterminator BglG; Provisional; Region: PRK09772 349519000614 CAT RNA binding domain; Region: CAT_RBD; smart01061 349519000615 PRD domain; Region: PRD; pfam00874 349519000616 PRD domain; Region: PRD; pfam00874 349519000617 PTS system beta-glucoside-specific transporter subunits IIABC; Provisional; Region: PRK09824 349519000618 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 349519000619 active site turn [active] 349519000620 phosphorylation site [posttranslational modification] 349519000621 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 349519000622 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 349519000623 HPr interaction site; other site 349519000624 glycerol kinase (GK) interaction site [polypeptide binding]; other site 349519000625 active site 349519000626 phosphorylation site [posttranslational modification] 349519000627 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 349519000628 MarR family; Region: MarR; pfam01047 349519000629 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 349519000630 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 349519000631 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 349519000632 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 349519000633 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 349519000634 putative NAD(P) binding site [chemical binding]; other site 349519000635 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 349519000636 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 349519000637 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 349519000638 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 349519000639 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 349519000640 Glycosyl hydrolase family 70; Region: Glyco_hydro_70; pfam02324 349519000641 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 349519000642 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 349519000643 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 349519000644 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 349519000645 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 349519000646 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 349519000647 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 349519000648 metal binding site [ion binding]; metal-binding site 349519000649 active site 349519000650 I-site; other site 349519000651 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 349519000652 Putative ClC chloride channel. Clc proteins are putative halogen ion (Cl-, Br- and I-) transporters found in eubacteria. They belong to the ClC superfamily of halogen ion channels, which share a unique double-barreled architecture and voltage-dependent...; Region: ClC_like; cd01033 349519000653 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 349519000654 putative ion selectivity filter; other site 349519000655 putative pore gating glutamate residue; other site 349519000656 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 349519000657 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 349519000658 non-specific DNA binding site [nucleotide binding]; other site 349519000659 salt bridge; other site 349519000660 sequence-specific DNA binding site [nucleotide binding]; other site 349519000661 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 349519000662 active site 349519000663 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 349519000664 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 349519000665 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 349519000666 ABC transporter; Region: ABC_tran_2; pfam12848 349519000667 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 349519000668 topology modulation protein; Provisional; Region: PRK07261 349519000669 AAA domain; Region: AAA_17; pfam13207 349519000670 alanine racemase; Reviewed; Region: alr; PRK00053 349519000671 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 349519000672 active site 349519000673 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 349519000674 dimer interface [polypeptide binding]; other site 349519000675 substrate binding site [chemical binding]; other site 349519000676 catalytic residues [active] 349519000677 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 349519000678 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 349519000679 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 349519000680 putative active site [active] 349519000681 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 349519000682 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 349519000683 Walker A/P-loop; other site 349519000684 ATP binding site [chemical binding]; other site 349519000685 Q-loop/lid; other site 349519000686 ABC transporter signature motif; other site 349519000687 Walker B; other site 349519000688 D-loop; other site 349519000689 H-loop/switch region; other site 349519000690 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 349519000691 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 349519000692 substrate binding pocket [chemical binding]; other site 349519000693 membrane-bound complex binding site; other site 349519000694 hinge residues; other site 349519000695 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 349519000696 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 349519000697 dimer interface [polypeptide binding]; other site 349519000698 conserved gate region; other site 349519000699 putative PBP binding loops; other site 349519000700 ABC-ATPase subunit interface; other site 349519000701 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 349519000702 dimer interface [polypeptide binding]; other site 349519000703 conserved gate region; other site 349519000704 putative PBP binding loops; other site 349519000705 ABC-ATPase subunit interface; other site 349519000706 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 349519000707 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 349519000708 peptide binding site [polypeptide binding]; other site 349519000709 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 349519000710 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 349519000711 dimer interface [polypeptide binding]; other site 349519000712 conserved gate region; other site 349519000713 putative PBP binding loops; other site 349519000714 ABC-ATPase subunit interface; other site 349519000715 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 349519000716 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 349519000717 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 349519000718 dimer interface [polypeptide binding]; other site 349519000719 conserved gate region; other site 349519000720 putative PBP binding loops; other site 349519000721 ABC-ATPase subunit interface; other site 349519000722 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 349519000723 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 349519000724 Walker A/P-loop; other site 349519000725 ATP binding site [chemical binding]; other site 349519000726 Q-loop/lid; other site 349519000727 ABC transporter signature motif; other site 349519000728 Walker B; other site 349519000729 D-loop; other site 349519000730 H-loop/switch region; other site 349519000731 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 349519000732 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 349519000733 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 349519000734 Walker A/P-loop; other site 349519000735 ATP binding site [chemical binding]; other site 349519000736 Q-loop/lid; other site 349519000737 ABC transporter signature motif; other site 349519000738 Walker B; other site 349519000739 D-loop; other site 349519000740 H-loop/switch region; other site 349519000741 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 349519000742 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 349519000743 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 349519000744 active site 349519000745 Zn binding site [ion binding]; other site 349519000746 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 349519000747 Aspartase; Region: Aspartase; cd01357 349519000748 active sites [active] 349519000749 tetramer interface [polypeptide binding]; other site 349519000750 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 349519000751 tetramer (dimer of dimers) interface [polypeptide binding]; other site 349519000752 active site 349519000753 dimer interface [polypeptide binding]; other site 349519000754 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 349519000755 Coenzyme A binding pocket [chemical binding]; other site 349519000756 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 349519000757 trimer interface [polypeptide binding]; other site 349519000758 active site 349519000759 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 349519000760 DNA repair protein RadA; Provisional; Region: PRK11823 349519000761 Walker A motif/ATP binding site; other site 349519000762 ATP binding site [chemical binding]; other site 349519000763 Walker B motif; other site 349519000764 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 349519000765 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 349519000766 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 349519000767 active site 349519000768 HIGH motif; other site 349519000769 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 349519000770 active site 349519000771 KMSKS motif; other site 349519000772 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 349519000773 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 349519000774 putative NAD(P) binding site [chemical binding]; other site 349519000775 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 349519000776 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 349519000777 NAD binding site [chemical binding]; other site 349519000778 substrate binding site [chemical binding]; other site 349519000779 catalytic Zn binding site [ion binding]; other site 349519000780 tetramer interface [polypeptide binding]; other site 349519000781 structural Zn binding site [ion binding]; other site 349519000782 hypothetical protein; Provisional; Region: PRK13661 349519000783 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 349519000784 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 349519000785 Walker A/P-loop; other site 349519000786 ATP binding site [chemical binding]; other site 349519000787 Q-loop/lid; other site 349519000788 ABC transporter signature motif; other site 349519000789 Walker B; other site 349519000790 D-loop; other site 349519000791 H-loop/switch region; other site 349519000792 ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558 349519000793 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 349519000794 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 349519000795 Walker A/P-loop; other site 349519000796 ATP binding site [chemical binding]; other site 349519000797 Q-loop/lid; other site 349519000798 ABC transporter signature motif; other site 349519000799 Walker B; other site 349519000800 D-loop; other site 349519000801 H-loop/switch region; other site 349519000802 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 349519000803 dipeptidase PepV; Reviewed; Region: PRK07318 349519000804 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 349519000805 active site 349519000806 metal binding site [ion binding]; metal-binding site 349519000807 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 349519000808 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 349519000809 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 349519000810 dimer interface [polypeptide binding]; other site 349519000811 ssDNA binding site [nucleotide binding]; other site 349519000812 tetramer (dimer of dimers) interface [polypeptide binding]; other site 349519000813 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 349519000814 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 349519000815 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 349519000816 DHH family; Region: DHH; pfam01368 349519000817 DHHA1 domain; Region: DHHA1; pfam02272 349519000818 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 349519000819 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 349519000820 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 349519000821 replicative DNA helicase; Region: DnaB; TIGR00665 349519000822 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 349519000823 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 349519000824 Walker A motif; other site 349519000825 ATP binding site [chemical binding]; other site 349519000826 Walker B motif; other site 349519000827 DNA binding loops [nucleotide binding] 349519000828 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 349519000829 putative deacylase active site [active] 349519000830 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 349519000831 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 349519000832 DNA-binding site [nucleotide binding]; DNA binding site 349519000833 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 349519000834 putative phosphoketolase; Provisional; Region: PRK05261 349519000835 XFP N-terminal domain; Region: XFP_N; pfam09364 349519000836 XFP C-terminal domain; Region: XFP_C; pfam09363 349519000837 histidinol-phosphatase; Reviewed; Region: PRK08123 349519000838 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 349519000839 active site 349519000840 dimer interface [polypeptide binding]; other site 349519000841 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 349519000842 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 349519000843 motif II; other site 349519000844 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 349519000845 nudix motif; other site 349519000846 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 349519000847 Major Facilitator Superfamily; Region: MFS_1; pfam07690 349519000848 putative substrate translocation pore; other site 349519000849 sugar phosphate phosphatase; Provisional; Region: PRK10513 349519000850 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 349519000851 active site 349519000852 motif I; other site 349519000853 motif II; other site 349519000854 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 349519000855 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 349519000856 dimer interface [polypeptide binding]; other site 349519000857 catalytic triad [active] 349519000858 peroxidatic and resolving cysteines [active] 349519000859 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 349519000860 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 349519000861 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 349519000862 active site 349519000863 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 349519000864 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 349519000865 active site 349519000866 phosphorylation site [posttranslational modification] 349519000867 intermolecular recognition site; other site 349519000868 dimerization interface [polypeptide binding]; other site 349519000869 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 349519000870 DNA binding site [nucleotide binding] 349519000871 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 349519000872 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 349519000873 dimerization interface [polypeptide binding]; other site 349519000874 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 349519000875 putative active site [active] 349519000876 heme pocket [chemical binding]; other site 349519000877 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 349519000878 dimer interface [polypeptide binding]; other site 349519000879 phosphorylation site [posttranslational modification] 349519000880 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 349519000881 ATP binding site [chemical binding]; other site 349519000882 Mg2+ binding site [ion binding]; other site 349519000883 G-X-G motif; other site 349519000884 YycH protein; Region: YycH; pfam07435 349519000885 YycH protein; Region: YycI; cl02015 349519000886 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 349519000887 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 349519000888 protein binding site [polypeptide binding]; other site 349519000889 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 349519000890 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 349519000891 Major Facilitator Superfamily; Region: MFS_1; pfam07690 349519000892 putative substrate translocation pore; other site 349519000893 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 349519000894 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 349519000895 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 349519000896 minor groove reading motif; other site 349519000897 helix-hairpin-helix signature motif; other site 349519000898 substrate binding pocket [chemical binding]; other site 349519000899 active site 349519000900 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 349519000901 DNA binding and oxoG recognition site [nucleotide binding] 349519000902 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 349519000903 Domain of unknown function DUF20; Region: UPF0118; pfam01594 349519000904 TRAM domain; Region: TRAM; pfam01938 349519000905 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 349519000906 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 349519000907 S-adenosylmethionine binding site [chemical binding]; other site 349519000908 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 349519000909 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 349519000910 Walker A motif; other site 349519000911 ATP binding site [chemical binding]; other site 349519000912 Walker B motif; other site 349519000913 arginine finger; other site 349519000914 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 349519000915 Walker A motif; other site 349519000916 ATP binding site [chemical binding]; other site 349519000917 Walker B motif; other site 349519000918 arginine finger; other site 349519000919 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 349519000920 37-kD nucleoid-associated bacterial protein; Region: NA37; pfam04245 349519000921 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 349519000922 nudix motif; other site 349519000923 Protein of unknown function (DUF1810); Region: DUF1810; cl02370 349519000924 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 349519000925 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 349519000926 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 349519000927 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 349519000928 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 349519000929 active site 349519000930 HIGH motif; other site 349519000931 dimer interface [polypeptide binding]; other site 349519000932 KMSKS motif; other site 349519000933 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 349519000934 Protein of unknown function (DUF1634); Region: DUF1634; pfam07843 349519000935 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 349519000936 lysine transporter; Provisional; Region: PRK10836 349519000937 Protein of unknown function (DUF1146); Region: DUF1146; pfam06612 349519000938 rod shape-determining protein MreB; Provisional; Region: PRK13930 349519000939 MreB and similar proteins; Region: MreB_like; cd10225 349519000940 nucleotide binding site [chemical binding]; other site 349519000941 Mg binding site [ion binding]; other site 349519000942 putative protofilament interaction site [polypeptide binding]; other site 349519000943 RodZ interaction site [polypeptide binding]; other site 349519000944 Protein of unknown function (DUF2969); Region: DUF2969; pfam11184 349519000945 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 349519000946 Protein of unknown function (DUF2785); Region: DUF2785; pfam10978 349519000947 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 349519000948 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 349519000949 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 349519000950 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 349519000951 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 349519000952 non-specific DNA binding site [nucleotide binding]; other site 349519000953 salt bridge; other site 349519000954 sequence-specific DNA binding site [nucleotide binding]; other site 349519000955 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 349519000956 Ligand Binding Site [chemical binding]; other site 349519000957 recombination factor protein RarA; Reviewed; Region: PRK13342 349519000958 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 349519000959 Walker A motif; other site 349519000960 ATP binding site [chemical binding]; other site 349519000961 Walker B motif; other site 349519000962 arginine finger; other site 349519000963 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 349519000964 Protein of unknown function (DUF1694); Region: DUF1694; pfam07997 349519000965 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 349519000966 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 349519000967 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 349519000968 RNA binding surface [nucleotide binding]; other site 349519000969 septation ring formation regulator EzrA; Provisional; Region: PRK04778 349519000970 amino acid transporter; Region: 2A0306; TIGR00909 349519000971 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 349519000972 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 349519000973 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 349519000974 active site 349519000975 aromatic amino acid aminotransferase; Validated; Region: PRK07309 349519000976 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 349519000977 pyridoxal 5'-phosphate binding site [chemical binding]; other site 349519000978 homodimer interface [polypeptide binding]; other site 349519000979 catalytic residue [active] 349519000980 D-lactate dehydrogenase; Validated; Region: PRK08605 349519000981 D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186 349519000982 homodimer interface [polypeptide binding]; other site 349519000983 ligand binding site [chemical binding]; other site 349519000984 NAD binding site [chemical binding]; other site 349519000985 catalytic site [active] 349519000986 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 349519000987 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 349519000988 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 349519000989 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 349519000990 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 349519000991 active site 349519000992 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 349519000993 dimer interface [polypeptide binding]; other site 349519000994 substrate binding site [chemical binding]; other site 349519000995 catalytic residues [active] 349519000996 PemK-like protein; Region: PemK; pfam02452 349519000997 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 349519000998 Acyltransferase family; Region: Acyl_transf_3; pfam01757 349519000999 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 349519001000 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 349519001001 active site 349519001002 HIGH motif; other site 349519001003 nucleotide binding site [chemical binding]; other site 349519001004 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 349519001005 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 349519001006 active site 349519001007 KMSKS motif; other site 349519001008 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 349519001009 tRNA binding surface [nucleotide binding]; other site 349519001010 anticodon binding site; other site 349519001011 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 349519001012 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 349519001013 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 349519001014 dimer interface [polypeptide binding]; other site 349519001015 active site 349519001016 CoA binding pocket [chemical binding]; other site 349519001017 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 349519001018 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 349519001019 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 349519001020 NlpC/P60 family; Region: NLPC_P60; cl17555 349519001021 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 349519001022 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 349519001023 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 349519001024 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 349519001025 FemAB family; Region: FemAB; pfam02388 349519001026 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 349519001027 PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396 349519001028 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 349519001029 active site 349519001030 exopolyphosphatase; Region: exo_poly_only; TIGR03706 349519001031 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 349519001032 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 349519001033 homodimer interface [polypeptide binding]; other site 349519001034 catalytic residues [active] 349519001035 NAD binding site [chemical binding]; other site 349519001036 substrate binding pocket [chemical binding]; other site 349519001037 flexible flap; other site 349519001038 NAD-dependent deacetylase; Provisional; Region: PRK00481 349519001039 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 349519001040 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 349519001041 manganese transport protein MntH; Reviewed; Region: PRK00701 349519001042 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 349519001043 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 349519001044 Ligand Binding Site [chemical binding]; other site 349519001045 Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300 349519001046 Cadmium resistance transporter; Region: Cad; pfam03596 349519001047 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 349519001048 dimerization interface [polypeptide binding]; other site 349519001049 putative DNA binding site [nucleotide binding]; other site 349519001050 putative Zn2+ binding site [ion binding]; other site 349519001051 Uncharacterized conserved protein (DUF2075); Region: DUF2075; pfam09848 349519001052 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 349519001053 Walker A motif; other site 349519001054 ATP binding site [chemical binding]; other site 349519001055 Walker B motif; other site 349519001056 Uncharacterized conserved protein [Function unknown]; Region: COG3410 349519001057 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 349519001058 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 349519001059 Ligand binding site; other site 349519001060 metal-binding site 349519001061 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 349519001062 active site 349519001063 tetramer interface [polypeptide binding]; other site 349519001064 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 349519001065 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 349519001066 S-adenosylmethionine binding site [chemical binding]; other site 349519001067 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 349519001068 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 349519001069 P-loop; other site 349519001070 Magnesium ion binding site [ion binding]; other site 349519001071 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 349519001072 ParB-like nuclease domain; Region: ParB; smart00470 349519001073 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 349519001074 GTP-binding protein YchF; Reviewed; Region: PRK09601 349519001075 YchF GTPase; Region: YchF; cd01900 349519001076 G1 box; other site 349519001077 GTP/Mg2+ binding site [chemical binding]; other site 349519001078 Switch I region; other site 349519001079 G2 box; other site 349519001080 Switch II region; other site 349519001081 G3 box; other site 349519001082 G4 box; other site 349519001083 G5 box; other site 349519001084 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 349519001085 Protein of unknown function (DUF1129); Region: DUF1129; cl11555 349519001086 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 349519001087 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 349519001088 active site 349519001089 phosphorylation site [posttranslational modification] 349519001090 intermolecular recognition site; other site 349519001091 dimerization interface [polypeptide binding]; other site 349519001092 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 349519001093 DNA binding site [nucleotide binding] 349519001094 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 349519001095 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 349519001096 dimer interface [polypeptide binding]; other site 349519001097 phosphorylation site [posttranslational modification] 349519001098 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 349519001099 ATP binding site [chemical binding]; other site 349519001100 Mg2+ binding site [ion binding]; other site 349519001101 G-X-G motif; other site 349519001102 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 349519001103 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 349519001104 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 349519001105 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 349519001106 active site 349519001107 trimer interface [polypeptide binding]; other site 349519001108 allosteric site; other site 349519001109 active site lid [active] 349519001110 hexamer (dimer of trimers) interface [polypeptide binding]; other site 349519001111 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 349519001112 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 349519001113 active site 349519001114 dimer interface [polypeptide binding]; other site 349519001115 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 349519001116 dimer interface [polypeptide binding]; other site 349519001117 active site 349519001118 Type II/IV secretion system protein; Region: T2SE; pfam00437 349519001119 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 349519001120 Walker A motif; other site 349519001121 ATP binding site [chemical binding]; other site 349519001122 Walker B motif; other site 349519001123 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 349519001124 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 349519001125 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 349519001126 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 349519001127 Methyltransferase domain; Region: Methyltransf_26; pfam13659 349519001128 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 349519001129 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 349519001130 propionate/acetate kinase; Provisional; Region: PRK12379 349519001131 proteins similar to Escherichia coli yceG; Region: yceG_like; cl17666 349519001132 dimerization interface [polypeptide binding]; other site 349519001133 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 349519001134 Sugar transport protein; Region: Sugar_transport; pfam06800 349519001135 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 349519001136 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 349519001137 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 349519001138 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 349519001139 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 349519001140 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 349519001141 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 349519001142 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 349519001143 NADH(P)-binding; Region: NAD_binding_10; pfam13460 349519001144 NAD(P) binding site [chemical binding]; other site 349519001145 active site 349519001146 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 349519001147 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 349519001148 Walker A motif; other site 349519001149 ATP binding site [chemical binding]; other site 349519001150 Walker B motif; other site 349519001151 Putative metallopeptidase domain; Region: DUF2201_N; pfam13203 349519001152 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 349519001153 metal ion-dependent adhesion site (MIDAS); other site 349519001154 Thiamine-precursor transporter protein (ThiW); Region: ThiW; pfam09512 349519001155 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 349519001156 substrate binding site [chemical binding]; other site 349519001157 multimerization interface [polypeptide binding]; other site 349519001158 ATP binding site [chemical binding]; other site 349519001159 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 349519001160 dimer interface [polypeptide binding]; other site 349519001161 substrate binding site [chemical binding]; other site 349519001162 ATP binding site [chemical binding]; other site 349519001163 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 349519001164 thiamine phosphate binding site [chemical binding]; other site 349519001165 active site 349519001166 pyrophosphate binding site [ion binding]; other site 349519001167 Predicted membrane protein [Function unknown]; Region: COG2035 349519001168 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 349519001169 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_2; cd09607 349519001170 active site 349519001171 Zn binding site [ion binding]; other site 349519001172 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 349519001173 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 349519001174 gamma-glutamyl kinase; Provisional; Region: PRK05429 349519001175 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 349519001176 nucleotide binding site [chemical binding]; other site 349519001177 homotetrameric interface [polypeptide binding]; other site 349519001178 putative phosphate binding site [ion binding]; other site 349519001179 putative allosteric binding site; other site 349519001180 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 349519001181 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 349519001182 putative catalytic cysteine [active] 349519001183 NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650 349519001184 active site 349519001185 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 349519001186 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 349519001187 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 349519001188 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; cl17626 349519001189 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 349519001190 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 349519001191 Walker A/P-loop; other site 349519001192 ATP binding site [chemical binding]; other site 349519001193 Q-loop/lid; other site 349519001194 ABC transporter signature motif; other site 349519001195 Walker B; other site 349519001196 D-loop; other site 349519001197 H-loop/switch region; other site 349519001198 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 349519001199 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 349519001200 dimer interface [polypeptide binding]; other site 349519001201 conserved gate region; other site 349519001202 putative PBP binding loops; other site 349519001203 ABC-ATPase subunit interface; other site 349519001204 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 349519001205 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 349519001206 substrate binding pocket [chemical binding]; other site 349519001207 membrane-bound complex binding site; other site 349519001208 hinge residues; other site 349519001209 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 349519001210 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 349519001211 Zn2+ binding site [ion binding]; other site 349519001212 Mg2+ binding site [ion binding]; other site 349519001213 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 349519001214 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 349519001215 active site 349519001216 HIGH motif; other site 349519001217 KMSKS motif; other site 349519001218 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 349519001219 tRNA binding surface [nucleotide binding]; other site 349519001220 anticodon binding site; other site 349519001221 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 349519001222 dimer interface [polypeptide binding]; other site 349519001223 putative tRNA-binding site [nucleotide binding]; other site 349519001224 Biotin operon repressor [Transcription]; Region: BirA; COG1654 349519001225 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 349519001226 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 349519001227 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 349519001228 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 349519001229 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 349519001230 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 349519001231 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 349519001232 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 349519001233 active site 349519001234 metal binding site [ion binding]; metal-binding site 349519001235 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 349519001236 MarR family; Region: MarR_2; pfam12802 349519001237 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 349519001238 MarR family; Region: MarR_2; cl17246 349519001239 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 349519001240 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 349519001241 dimer interface [polypeptide binding]; other site 349519001242 active site 349519001243 CoA binding pocket [chemical binding]; other site 349519001244 acyl carrier protein; Provisional; Region: acpP; PRK00982 349519001245 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 349519001246 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 349519001247 FMN binding site [chemical binding]; other site 349519001248 substrate binding site [chemical binding]; other site 349519001249 putative catalytic residue [active] 349519001250 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 349519001251 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 349519001252 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 349519001253 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 349519001254 NAD(P) binding site [chemical binding]; other site 349519001255 homotetramer interface [polypeptide binding]; other site 349519001256 homodimer interface [polypeptide binding]; other site 349519001257 active site 349519001258 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 349519001259 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 349519001260 dimer interface [polypeptide binding]; other site 349519001261 active site 349519001262 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 349519001263 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 349519001264 carboxyltransferase (CT) interaction site; other site 349519001265 biotinylation site [posttranslational modification]; other site 349519001266 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 349519001267 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 349519001268 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 349519001269 ATP-grasp domain; Region: ATP-grasp_4; cl17255 349519001270 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 349519001271 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 349519001272 Ribosomal protein L37e; Region: Ribosomal_L37e; cl00932 349519001273 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 349519001274 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 349519001275 Protein of unknown function (DUF805); Region: DUF805; cl01224 349519001276 Domain of unknown function (DUF4018); Region: DUF4018; pfam13210 349519001277 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 349519001278 S-adenosylmethionine binding site [chemical binding]; other site 349519001279 topology modulation protein; Reviewed; Region: PRK08118 349519001280 AAA domain; Region: AAA_17; pfam13207 349519001281 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 349519001282 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 349519001283 DNA binding residues [nucleotide binding] 349519001284 dimer interface [polypeptide binding]; other site 349519001285 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 349519001286 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 349519001287 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 349519001288 non-specific DNA binding site [nucleotide binding]; other site 349519001289 salt bridge; other site 349519001290 sequence-specific DNA binding site [nucleotide binding]; other site 349519001291 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 349519001292 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 349519001293 Coenzyme A binding pocket [chemical binding]; other site 349519001294 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 349519001295 NADH(P)-binding; Region: NAD_binding_10; pfam13460 349519001296 NAD(P) binding site [chemical binding]; other site 349519001297 active site 349519001298 TspO/MBR family; Region: TspO_MBR; pfam03073 349519001299 Protein of unknown function (DUF1706); Region: DUF1706; pfam08020 349519001300 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 349519001301 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 349519001302 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 349519001303 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 349519001304 substrate binding pocket [chemical binding]; other site 349519001305 catalytic triad [active] 349519001306 ribonuclease HIII; Provisional; Region: PRK00996 349519001307 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 349519001308 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 349519001309 RNA/DNA hybrid binding site [nucleotide binding]; other site 349519001310 active site 349519001311 Colicin V production protein; Region: Colicin_V; pfam02674 349519001312 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 349519001313 MutS domain III; Region: MutS_III; pfam05192 349519001314 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 349519001315 Walker A/P-loop; other site 349519001316 ATP binding site [chemical binding]; other site 349519001317 Q-loop/lid; other site 349519001318 ABC transporter signature motif; other site 349519001319 Walker B; other site 349519001320 D-loop; other site 349519001321 H-loop/switch region; other site 349519001322 Smr domain; Region: Smr; pfam01713 349519001323 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 349519001324 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 349519001325 DNA binding site [nucleotide binding] 349519001326 catalytic residue [active] 349519001327 H2TH interface [polypeptide binding]; other site 349519001328 putative catalytic residues [active] 349519001329 turnover-facilitating residue; other site 349519001330 intercalation triad [nucleotide binding]; other site 349519001331 8OG recognition residue [nucleotide binding]; other site 349519001332 putative reading head residues; other site 349519001333 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 349519001334 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 349519001335 Protein of unknown function (DUF975); Region: DUF975; cl10504 349519001336 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 349519001337 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 349519001338 CoA-binding site [chemical binding]; other site 349519001339 ATP-binding [chemical binding]; other site 349519001340 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 349519001341 primosomal protein DnaI; Reviewed; Region: PRK08939 349519001342 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 349519001343 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 349519001344 Walker A motif; other site 349519001345 ATP binding site [chemical binding]; other site 349519001346 Walker B motif; other site 349519001347 YibE/F-like protein; Region: YibE_F; pfam07907 349519001348 YibE/F-like protein; Region: YibE_F; pfam07907 349519001349 Protein of unknown function (DUF2185); Region: DUF2185; cl02019 349519001350 beta-1,6-galactofuranosyltransferase; Provisional; Region: PRK09814 349519001351 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 349519001352 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 349519001353 ligand binding site [chemical binding]; other site 349519001354 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 349519001355 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 349519001356 substrate binding pocket [chemical binding]; other site 349519001357 membrane-bound complex binding site; other site 349519001358 hinge residues; other site 349519001359 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 349519001360 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 349519001361 dimer interface [polypeptide binding]; other site 349519001362 conserved gate region; other site 349519001363 putative PBP binding loops; other site 349519001364 ABC-ATPase subunit interface; other site 349519001365 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 349519001366 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 349519001367 Walker A/P-loop; other site 349519001368 ATP binding site [chemical binding]; other site 349519001369 Q-loop/lid; other site 349519001370 ABC transporter signature motif; other site 349519001371 Walker B; other site 349519001372 D-loop; other site 349519001373 H-loop/switch region; other site 349519001374 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 349519001375 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 349519001376 substrate binding pocket [chemical binding]; other site 349519001377 membrane-bound complex binding site; other site 349519001378 hinge residues; other site 349519001379 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 349519001380 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 349519001381 dimer interface [polypeptide binding]; other site 349519001382 conserved gate region; other site 349519001383 putative PBP binding loops; other site 349519001384 ABC-ATPase subunit interface; other site 349519001385 Competence protein CoiA-like family; Region: CoiA; cl11541 349519001386 Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164 349519001387 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 349519001388 active site 349519001389 Zn binding site [ion binding]; other site 349519001390 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 349519001391 active site 349519001392 catalytic motif [active] 349519001393 Zn binding site [ion binding]; other site 349519001394 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 349519001395 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 349519001396 NAD binding site [chemical binding]; other site 349519001397 Transcriptional regulators [Transcription]; Region: PurR; COG1609 349519001398 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 349519001399 DNA binding site [nucleotide binding] 349519001400 domain linker motif; other site 349519001401 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 349519001402 dimerization interface [polypeptide binding]; other site 349519001403 ligand binding site [chemical binding]; other site 349519001404 sodium binding site [ion binding]; other site 349519001405 L-threonine dehydrogenase; Region: threonine_DH_like; cd08234 349519001406 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 349519001407 putative NAD(P) binding site [chemical binding]; other site 349519001408 catalytic Zn binding site [ion binding]; other site 349519001409 Predicted membrane protein [Function unknown]; Region: COG2364 349519001410 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 349519001411 active site 349519001412 sucrose phosphorylase; Region: sucrose_gtfA; TIGR03852 349519001413 Alpha amylase catalytic domain found in sucrose phosphorylase (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase; cd11355 349519001414 active site 349519001415 homodimer interface [polypeptide binding]; other site 349519001416 catalytic site [active] 349519001417 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 349519001418 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 349519001419 nucleotide binding site [chemical binding]; other site 349519001420 Predicted transcriptional regulators [Transcription]; Region: COG1733 349519001421 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 349519001422 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 349519001423 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 349519001424 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 349519001425 dimer interface [polypeptide binding]; other site 349519001426 motif 1; other site 349519001427 active site 349519001428 motif 2; other site 349519001429 motif 3; other site 349519001430 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 349519001431 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 349519001432 putative tRNA-binding site [nucleotide binding]; other site 349519001433 B3/4 domain; Region: B3_4; pfam03483 349519001434 tRNA synthetase B5 domain; Region: B5; smart00874 349519001435 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 349519001436 dimer interface [polypeptide binding]; other site 349519001437 motif 1; other site 349519001438 motif 3; other site 349519001439 motif 2; other site 349519001440 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 349519001441 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 349519001442 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 349519001443 hinge; other site 349519001444 active site 349519001445 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 349519001446 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 349519001447 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 349519001448 S-adenosylmethionine binding site [chemical binding]; other site 349519001449 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 349519001450 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 349519001451 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 349519001452 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 349519001453 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 349519001454 Beta-lactamase; Region: Beta-lactamase; pfam00144 349519001455 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 349519001456 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 349519001457 ATP binding site [chemical binding]; other site 349519001458 Mg++ binding site [ion binding]; other site 349519001459 motif III; other site 349519001460 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 349519001461 nucleotide binding region [chemical binding]; other site 349519001462 ATP-binding site [chemical binding]; other site 349519001463 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 349519001464 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 349519001465 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 349519001466 Major Facilitator Superfamily; Region: MFS_1; pfam07690 349519001467 putative substrate translocation pore; other site 349519001468 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 349519001469 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 349519001470 MPN+ (JAMM) motif; other site 349519001471 Zinc-binding site [ion binding]; other site 349519001472 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 349519001473 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 349519001474 preprotein translocase subunit YajC; Validated; Region: yajC; PRK06531 349519001475 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 349519001476 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 349519001477 Predicted integral membrane protein [Function unknown]; Region: COG0392 349519001478 Uncharacterized conserved protein [Function unknown]; Region: COG2898 349519001479 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 349519001480 HD domain; Region: HD_3; cl17350 349519001481 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 349519001482 nudix motif; other site 349519001483 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 349519001484 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 349519001485 Walker A/P-loop; other site 349519001486 ATP binding site [chemical binding]; other site 349519001487 Q-loop/lid; other site 349519001488 ABC transporter signature motif; other site 349519001489 Walker B; other site 349519001490 D-loop; other site 349519001491 H-loop/switch region; other site 349519001492 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 349519001493 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 349519001494 FtsX-like permease family; Region: FtsX; pfam02687 349519001495 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 349519001496 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 349519001497 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 349519001498 Walker A/P-loop; other site 349519001499 ATP binding site [chemical binding]; other site 349519001500 Q-loop/lid; other site 349519001501 ABC transporter signature motif; other site 349519001502 Walker B; other site 349519001503 D-loop; other site 349519001504 H-loop/switch region; other site 349519001505 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 349519001506 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 349519001507 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 349519001508 Walker A/P-loop; other site 349519001509 ATP binding site [chemical binding]; other site 349519001510 Q-loop/lid; other site 349519001511 ABC transporter signature motif; other site 349519001512 Walker B; other site 349519001513 D-loop; other site 349519001514 H-loop/switch region; other site 349519001515 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 349519001516 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 349519001517 putative ADP-binding pocket [chemical binding]; other site 349519001518 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 349519001519 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 349519001520 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 349519001521 Protein of unknown function (DUF1797); Region: DUF1797; cl11550 349519001522 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 349519001523 Sulfatase; Region: Sulfatase; pfam00884 349519001524 excinuclease ABC subunit B; Provisional; Region: PRK05298 349519001525 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 349519001526 ATP binding site [chemical binding]; other site 349519001527 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 349519001528 nucleotide binding region [chemical binding]; other site 349519001529 ATP-binding site [chemical binding]; other site 349519001530 Ultra-violet resistance protein B; Region: UvrB; pfam12344 349519001531 UvrB/uvrC motif; Region: UVR; pfam02151 349519001532 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 349519001533 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 349519001534 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 349519001535 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 349519001536 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 349519001537 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 349519001538 phosphate binding site [ion binding]; other site 349519001539 putative substrate binding pocket [chemical binding]; other site 349519001540 dimer interface [polypeptide binding]; other site 349519001541 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 349519001542 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 349519001543 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 349519001544 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 349519001545 oligomer interface [polypeptide binding]; other site 349519001546 active site residues [active] 349519001547 D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186 349519001548 D-lactate dehydrogenase; Validated; Region: PRK08605 349519001549 homodimer interface [polypeptide binding]; other site 349519001550 ligand binding site [chemical binding]; other site 349519001551 NAD binding site [chemical binding]; other site 349519001552 catalytic site [active] 349519001553 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 349519001554 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 349519001555 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 349519001556 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 349519001557 active site 349519001558 motif I; other site 349519001559 motif II; other site 349519001560 GTPase YqeH; Provisional; Region: PRK13796 349519001561 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 349519001562 GTP/Mg2+ binding site [chemical binding]; other site 349519001563 G4 box; other site 349519001564 G5 box; other site 349519001565 G1 box; other site 349519001566 Switch I region; other site 349519001567 G2 box; other site 349519001568 G3 box; other site 349519001569 Switch II region; other site 349519001570 CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; pfam01985 349519001571 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 349519001572 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 349519001573 active site 349519001574 (T/H)XGH motif; other site 349519001575 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 349519001576 Zn2+ binding site [ion binding]; other site 349519001577 Mg2+ binding site [ion binding]; other site 349519001578 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 349519001579 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 349519001580 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673 349519001581 hypothetical protein; Provisional; Region: PRK13670 349519001582 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 349519001583 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 349519001584 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 349519001585 active site 349519001586 phosphorylation site [posttranslational modification] 349519001587 intermolecular recognition site; other site 349519001588 dimerization interface [polypeptide binding]; other site 349519001589 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 349519001590 DNA binding site [nucleotide binding] 349519001591 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 349519001592 HAMP domain; Region: HAMP; pfam00672 349519001593 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 349519001594 dimer interface [polypeptide binding]; other site 349519001595 phosphorylation site [posttranslational modification] 349519001596 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 349519001597 ATP binding site [chemical binding]; other site 349519001598 Mg2+ binding site [ion binding]; other site 349519001599 G-X-G motif; other site 349519001600 Acylphosphatase; Region: Acylphosphatase; pfam00708 349519001601 OxaA-like protein precursor; Provisional; Region: PRK02463 349519001602 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 349519001603 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 349519001604 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 349519001605 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 349519001606 Preprotein translocase SecG subunit; Region: SecG; pfam03840 349519001607 ribonuclease R; Region: RNase_R; TIGR02063 349519001608 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 349519001609 RNB domain; Region: RNB; pfam00773 349519001610 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 349519001611 RNA binding site [nucleotide binding]; other site 349519001612 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 349519001613 SmpB-tmRNA interface; other site 349519001614 phosphodiesterase; Provisional; Region: PRK12704 349519001615 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 349519001616 Zn2+ binding site [ion binding]; other site 349519001617 Mg2+ binding site [ion binding]; other site 349519001618 Bacterial protein of unknown function (DUF948); Region: DUF948; pfam06103 349519001619 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 349519001620 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 349519001621 catalytic site [active] 349519001622 G-X2-G-X-G-K; other site 349519001623 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 349519001624 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 349519001625 active site 349519001626 general stress protein 13; Validated; Region: PRK08059 349519001627 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cd00164 349519001628 RNA binding site [nucleotide binding]; other site 349519001629 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 349519001630 ArsC family; Region: ArsC; pfam03960 349519001631 putative catalytic residues [active] 349519001632 thiol/disulfide switch; other site 349519001633 adaptor protein; Provisional; Region: PRK02315 349519001634 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 349519001635 active site residue [active] 349519001636 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 349519001637 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 349519001638 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 349519001639 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 349519001640 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 349519001641 tetramer interface [polypeptide binding]; other site 349519001642 TPP-binding site [chemical binding]; other site 349519001643 heterodimer interface [polypeptide binding]; other site 349519001644 phosphorylation loop region [posttranslational modification] 349519001645 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 349519001646 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 349519001647 alpha subunit interface [polypeptide binding]; other site 349519001648 TPP binding site [chemical binding]; other site 349519001649 heterodimer interface [polypeptide binding]; other site 349519001650 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 349519001651 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 349519001652 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 349519001653 E3 interaction surface; other site 349519001654 lipoyl attachment site [posttranslational modification]; other site 349519001655 e3 binding domain; Region: E3_binding; pfam02817 349519001656 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 349519001657 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 349519001658 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 349519001659 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 349519001660 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 349519001661 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 349519001662 putative alkyl hydroperoxide reductase F subunit; Region: AhpF_homolog; TIGR03143 349519001663 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 349519001664 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 349519001665 catalytic residue [active] 349519001666 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 349519001667 catalytic residues [active] 349519001668 peroxiredoxin; Region: AhpC; TIGR03137 349519001669 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 349519001670 dimer interface [polypeptide binding]; other site 349519001671 decamer (pentamer of dimers) interface [polypeptide binding]; other site 349519001672 catalytic triad [active] 349519001673 peroxidatic and resolving cysteines [active] 349519001674 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 349519001675 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 349519001676 2-deoxy-D-gluconate 3-dehydrogenase; Provisional; Region: PRK06935 349519001677 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 349519001678 NADP binding site [chemical binding]; other site 349519001679 homodimer interface [polypeptide binding]; other site 349519001680 active site 349519001681 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 349519001682 Major Facilitator Superfamily; Region: MFS_1; pfam07690 349519001683 putative substrate translocation pore; other site 349519001684 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 349519001685 putative substrate translocation pore; other site 349519001686 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 349519001687 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 349519001688 Protein of unknown function (DUF3042); Region: DUF3042; pfam11240 349519001689 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 349519001690 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 349519001691 active site 349519001692 catalytic site [active] 349519001693 metal binding site [ion binding]; metal-binding site 349519001694 dimer interface [polypeptide binding]; other site 349519001695 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 349519001696 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 349519001697 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 349519001698 Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601 349519001699 Aminopeptidase N [Amino acid transport and metabolism]; Region: PepN; COG0308 349519001700 Zn binding site [ion binding]; other site 349519001701 benzoate transport; Region: 2A0115; TIGR00895 349519001702 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 349519001703 putative substrate translocation pore; other site 349519001704 YceI-like domain; Region: YceI; pfam04264 349519001705 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 349519001706 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 349519001707 Zn2+ binding site [ion binding]; other site 349519001708 Mg2+ binding site [ion binding]; other site 349519001709 Domain of unknown function (DUF1934); Region: DUF1934; pfam09148 349519001710 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 349519001711 putative transport protein YifK; Provisional; Region: PRK10746 349519001712 putative phosphate acyltransferase; Provisional; Region: PRK05331 349519001713 acyl carrier protein; Provisional; Region: acpP; PRK00982 349519001714 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 349519001715 GAF domain; Region: GAF_2; pfam13185 349519001716 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 349519001717 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 349519001718 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 349519001719 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 349519001720 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 349519001721 ABC-ATPase subunit interface; other site 349519001722 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 349519001723 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 349519001724 SprT homologues; Region: SprT; cl01182 349519001725 hypothetical protein; Provisional; Region: PRK04351 349519001726 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 349519001727 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 349519001728 active site 349519001729 motif I; other site 349519001730 motif II; other site 349519001731 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 349519001732 CAAX protease self-immunity; Region: Abi; pfam02517 349519001733 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 349519001734 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 349519001735 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 349519001736 active site 349519001737 catabolite control protein A; Region: ccpA; TIGR01481 349519001738 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 349519001739 DNA binding site [nucleotide binding] 349519001740 domain linker motif; other site 349519001741 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 349519001742 dimerization interface [polypeptide binding]; other site 349519001743 effector binding site; other site 349519001744 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 349519001745 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 349519001746 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 349519001747 catalytic triad [active] 349519001748 catalytic triad [active] 349519001749 oxyanion hole [active] 349519001750 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306 349519001751 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 349519001752 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 349519001753 Sugar specificity; other site 349519001754 Pyrimidine base specificity; other site 349519001755 ATP-binding site [chemical binding]; other site 349519001756 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 349519001757 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 349519001758 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 349519001759 putative active site [active] 349519001760 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 349519001761 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 349519001762 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 349519001763 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 349519001764 N- and C-terminal domain interface [polypeptide binding]; other site 349519001765 active site 349519001766 catalytic site [active] 349519001767 metal binding site [ion binding]; metal-binding site 349519001768 carbohydrate binding site [chemical binding]; other site 349519001769 ATP binding site [chemical binding]; other site 349519001770 GntP family permease; Region: GntP_permease; pfam02447 349519001771 fructuronate transporter; Provisional; Region: PRK10034; cl15264 349519001772 amino acid transporter; Region: 2A0306; TIGR00909 349519001773 4-aminobutyrate aminotransferase; Provisional; Region: PRK08593 349519001774 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 349519001775 inhibitor-cofactor binding pocket; inhibition site 349519001776 pyridoxal 5'-phosphate binding site [chemical binding]; other site 349519001777 catalytic residue [active] 349519001778 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 349519001779 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 349519001780 motif 1; other site 349519001781 active site 349519001782 motif 2; other site 349519001783 motif 3; other site 349519001784 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 349519001785 DHHA1 domain; Region: DHHA1; pfam02272 349519001786 hypothetical protein; Provisional; Region: PRK05473 349519001787 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 349519001788 hypothetical protein; Provisional; Region: PRK13678 349519001789 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 349519001790 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 349519001791 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 349519001792 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 349519001793 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 349519001794 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 349519001795 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 349519001796 Walker A/P-loop; other site 349519001797 ATP binding site [chemical binding]; other site 349519001798 Q-loop/lid; other site 349519001799 ABC transporter signature motif; other site 349519001800 Walker B; other site 349519001801 D-loop; other site 349519001802 H-loop/switch region; other site 349519001803 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 349519001804 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 349519001805 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 349519001806 Walker A/P-loop; other site 349519001807 ATP binding site [chemical binding]; other site 349519001808 Q-loop/lid; other site 349519001809 ABC transporter signature motif; other site 349519001810 Walker B; other site 349519001811 D-loop; other site 349519001812 H-loop/switch region; other site 349519001813 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 349519001814 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 349519001815 Part of AAA domain; Region: AAA_19; pfam13245 349519001816 Family description; Region: UvrD_C_2; pfam13538 349519001817 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 349519001818 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 349519001819 nucleotide binding pocket [chemical binding]; other site 349519001820 K-X-D-G motif; other site 349519001821 catalytic site [active] 349519001822 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 349519001823 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 349519001824 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 349519001825 Dimer interface [polypeptide binding]; other site 349519001826 BRCT sequence motif; other site 349519001827 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 349519001828 putative dimer interface [polypeptide binding]; other site 349519001829 CamS sex pheromone cAM373 precursor; Region: CamS; pfam07537 349519001830 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 349519001831 putative dimer interface [polypeptide binding]; other site 349519001832 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 349519001833 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 349519001834 generic binding surface II; other site 349519001835 generic binding surface I; other site 349519001836 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 349519001837 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 349519001838 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 349519001839 substrate binding pocket [chemical binding]; other site 349519001840 chain length determination region; other site 349519001841 catalytic residues [active] 349519001842 aspartate-rich region 1; other site 349519001843 substrate-Mg2+ binding site; other site 349519001844 active site lid residues [active] 349519001845 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 349519001846 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 349519001847 RNA binding surface [nucleotide binding]; other site 349519001848 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 349519001849 S-adenosylmethionine binding site [chemical binding]; other site 349519001850 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 349519001851 Arginine repressor [Transcription]; Region: ArgR; COG1438 349519001852 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 349519001853 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 349519001854 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 349519001855 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 349519001856 Walker A/P-loop; other site 349519001857 ATP binding site [chemical binding]; other site 349519001858 Q-loop/lid; other site 349519001859 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 349519001860 ABC transporter signature motif; other site 349519001861 Walker B; other site 349519001862 D-loop; other site 349519001863 H-loop/switch region; other site 349519001864 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 349519001865 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 349519001866 catalytic core [active] 349519001867 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 349519001868 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 349519001869 oligomer interface [polypeptide binding]; other site 349519001870 active site 349519001871 metal binding site [ion binding]; metal-binding site 349519001872 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 349519001873 Uncharacterized protein conserved in bacteria (DUF2129); Region: DUF2129; pfam09902 349519001874 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 349519001875 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 349519001876 S-adenosylmethionine binding site [chemical binding]; other site 349519001877 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 349519001878 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 349519001879 active site 349519001880 (T/H)XGH motif; other site 349519001881 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 349519001882 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 349519001883 protein binding site [polypeptide binding]; other site 349519001884 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 349519001885 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 349519001886 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 349519001887 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 349519001888 homodimer interface [polypeptide binding]; other site 349519001889 NAD binding pocket [chemical binding]; other site 349519001890 ATP binding pocket [chemical binding]; other site 349519001891 Mg binding site [ion binding]; other site 349519001892 active-site loop [active] 349519001893 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 349519001894 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 349519001895 active site 349519001896 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 349519001897 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 349519001898 Coenzyme A binding pocket [chemical binding]; other site 349519001899 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 349519001900 active site 349519001901 catalytic site [active] 349519001902 substrate binding site [chemical binding]; other site 349519001903 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 349519001904 active site 349519001905 putative catalytic site [active] 349519001906 DNA binding site [nucleotide binding] 349519001907 putative phosphate binding site [ion binding]; other site 349519001908 metal binding site A [ion binding]; metal-binding site 349519001909 AP binding site [nucleotide binding]; other site 349519001910 metal binding site B [ion binding]; metal-binding site 349519001911 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 349519001912 putative substrate binding site [chemical binding]; other site 349519001913 putative ATP binding site [chemical binding]; other site 349519001914 dipeptidase PepV; Reviewed; Region: PRK07318 349519001915 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 349519001916 active site 349519001917 metal binding site [ion binding]; metal-binding site 349519001918 nicotinamide-nucleotide adenylyltransferase, NadR type; Region: nadR_NMN_Atrans; TIGR01526 349519001919 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 349519001920 active site 349519001921 nucleotide binding site [chemical binding]; other site 349519001922 HIGH motif; other site 349519001923 KMSKS motif; other site 349519001924 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 349519001925 acetoin reductases; Region: 23BDH; TIGR02415 349519001926 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 349519001927 NAD(P) binding site [chemical binding]; other site 349519001928 active site 349519001929 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 349519001930 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 349519001931 Na binding site [ion binding]; other site 349519001932 trigger factor; Provisional; Region: tig; PRK01490 349519001933 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 349519001934 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 349519001935 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 349519001936 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 349519001937 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 349519001938 Walker A motif; other site 349519001939 ATP binding site [chemical binding]; other site 349519001940 Walker B motif; other site 349519001941 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 349519001942 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 349519001943 G1 box; other site 349519001944 GTP/Mg2+ binding site [chemical binding]; other site 349519001945 Switch I region; other site 349519001946 G2 box; other site 349519001947 G3 box; other site 349519001948 Switch II region; other site 349519001949 G4 box; other site 349519001950 G5 box; other site 349519001951 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 349519001952 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 349519001953 ATP binding site [chemical binding]; other site 349519001954 putative Mg++ binding site [ion binding]; other site 349519001955 helicase superfamily c-terminal domain; Region: HELICc; smart00490 349519001956 ATP-binding site [chemical binding]; other site 349519001957 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 349519001958 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 349519001959 putative active site [active] 349519001960 substrate binding site [chemical binding]; other site 349519001961 putative cosubstrate binding site; other site 349519001962 catalytic site [active] 349519001963 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 349519001964 substrate binding site [chemical binding]; other site 349519001965 16S rRNA methyltransferase B; Provisional; Region: PRK14902 349519001966 NusB family; Region: NusB; pfam01029 349519001967 putative RNA binding site [nucleotide binding]; other site 349519001968 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 349519001969 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 349519001970 active site 349519001971 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 349519001972 Catalytic domain of Protein Kinases; Region: PKc; cd00180 349519001973 active site 349519001974 ATP binding site [chemical binding]; other site 349519001975 substrate binding site [chemical binding]; other site 349519001976 activation loop (A-loop); other site 349519001977 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 349519001978 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 349519001979 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 349519001980 GTPase RsgA; Reviewed; Region: PRK00098 349519001981 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 349519001982 RNA binding site [nucleotide binding]; other site 349519001983 homodimer interface [polypeptide binding]; other site 349519001984 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 349519001985 GTPase/Zn-binding domain interface [polypeptide binding]; other site 349519001986 GTP/Mg2+ binding site [chemical binding]; other site 349519001987 G4 box; other site 349519001988 G5 box; other site 349519001989 G1 box; other site 349519001990 Switch I region; other site 349519001991 G2 box; other site 349519001992 G3 box; other site 349519001993 Switch II region; other site 349519001994 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 349519001995 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 349519001996 substrate binding site [chemical binding]; other site 349519001997 hexamer interface [polypeptide binding]; other site 349519001998 metal binding site [ion binding]; metal-binding site 349519001999 Thiamine pyrophosphokinase; Region: TPK; cd07995 349519002000 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 349519002001 active site 349519002002 dimerization interface [polypeptide binding]; other site 349519002003 thiamine binding site [chemical binding]; other site 349519002004 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 349519002005 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 349519002006 catalytic residues [active] 349519002007 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 349519002008 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 349519002009 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 349519002010 DAK2 domain; Region: Dak2; pfam02734 349519002011 Protein of unknown function (DUF4044); Region: DUF4044; pfam13253 349519002012 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 349519002013 cell division protein MraZ; Reviewed; Region: PRK00326 349519002014 MraZ protein; Region: MraZ; pfam02381 349519002015 MraZ protein; Region: MraZ; pfam02381 349519002016 MraW methylase family; Region: Methyltransf_5; pfam01795 349519002017 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 349519002018 Cell division protein FtsL; Region: FtsL; cl11433 349519002019 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 349519002020 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 349519002021 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 349519002022 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 349519002023 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 349519002024 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 349519002025 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 349519002026 Mg++ binding site [ion binding]; other site 349519002027 putative catalytic motif [active] 349519002028 putative substrate binding site [chemical binding]; other site 349519002029 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 349519002030 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 349519002031 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 349519002032 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 349519002033 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 349519002034 active site 349519002035 homodimer interface [polypeptide binding]; other site 349519002036 Cell division protein FtsQ; Region: FtsQ; pfam03799 349519002037 cell division protein FtsA; Region: ftsA; TIGR01174 349519002038 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 349519002039 nucleotide binding site [chemical binding]; other site 349519002040 SHS2 domain inserted in FTSA; Region: SHS2_FTSA; pfam02491 349519002041 Cell division protein FtsA; Region: FtsA; pfam14450 349519002042 cell division protein FtsZ; Validated; Region: PRK09330 349519002043 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 349519002044 nucleotide binding site [chemical binding]; other site 349519002045 SulA interaction site; other site 349519002046 Protein of unknown function (DUF552); Region: DUF552; pfam04472 349519002047 YGGT family; Region: YGGT; pfam02325 349519002048 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 349519002049 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 349519002050 RNA binding surface [nucleotide binding]; other site 349519002051 DivIVA protein; Region: DivIVA; pfam05103 349519002052 DivIVA domain; Region: DivI1A_domain; TIGR03544 349519002053 isoleucyl-tRNA synthetase; Provisional; Region: ileS; PRK13804 349519002054 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 349519002055 active site 349519002056 HIGH motif; other site 349519002057 nucleotide binding site [chemical binding]; other site 349519002058 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 349519002059 active site 349519002060 KMSKS motif; other site 349519002061 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 349519002062 tRNA binding surface [nucleotide binding]; other site 349519002063 anticodon binding site; other site 349519002064 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 349519002065 active site 349519002066 P-loop; other site 349519002067 phosphorylation site [posttranslational modification] 349519002068 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 349519002069 active site 349519002070 methionine cluster; other site 349519002071 phosphorylation site [posttranslational modification] 349519002072 metal binding site [ion binding]; metal-binding site 349519002073 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 349519002074 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 349519002075 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 349519002076 active site 349519002077 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 349519002078 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 349519002079 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 349519002080 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 349519002081 putative ligand binding site [chemical binding]; other site 349519002082 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 349519002083 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 349519002084 TM-ABC transporter signature motif; other site 349519002085 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 349519002086 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 349519002087 TM-ABC transporter signature motif; other site 349519002088 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 349519002089 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 349519002090 Walker A/P-loop; other site 349519002091 ATP binding site [chemical binding]; other site 349519002092 Q-loop/lid; other site 349519002093 ABC transporter signature motif; other site 349519002094 Walker B; other site 349519002095 D-loop; other site 349519002096 H-loop/switch region; other site 349519002097 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 349519002098 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 349519002099 Walker A/P-loop; other site 349519002100 ATP binding site [chemical binding]; other site 349519002101 Q-loop/lid; other site 349519002102 ABC transporter signature motif; other site 349519002103 Walker B; other site 349519002104 D-loop; other site 349519002105 H-loop/switch region; other site 349519002106 S-methylmethionine transporter; Provisional; Region: PRK11387 349519002107 homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485 349519002108 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 349519002109 Tubby C 2; Region: Tub_2; cl02043 349519002110 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 349519002111 ligand binding site [chemical binding]; other site 349519002112 active site 349519002113 UGI interface [polypeptide binding]; other site 349519002114 catalytic site [active] 349519002115 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 349519002116 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 349519002117 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 349519002118 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 349519002119 Walker A/P-loop; other site 349519002120 ATP binding site [chemical binding]; other site 349519002121 Q-loop/lid; other site 349519002122 ABC transporter signature motif; other site 349519002123 Walker B; other site 349519002124 D-loop; other site 349519002125 H-loop/switch region; other site 349519002126 3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355 349519002127 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 349519002128 catalytic residue [active] 349519002129 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_3; cd12174 349519002130 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 349519002131 putative ligand binding site [chemical binding]; other site 349519002132 putative NAD binding site [chemical binding]; other site 349519002133 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 349519002134 L-serine binding site [chemical binding]; other site 349519002135 ACT domain interface; other site 349519002136 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 349519002137 tetramer interfaces [polypeptide binding]; other site 349519002138 binuclear metal-binding site [ion binding]; other site 349519002139 hypothetical protein; Validated; Region: PRK00110 349519002140 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 349519002141 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 349519002142 amphipathic channel; other site 349519002143 Asn-Pro-Ala signature motifs; other site 349519002144 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 349519002145 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 349519002146 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 349519002147 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 349519002148 active site 349519002149 dimer interface [polypeptide binding]; other site 349519002150 motif 1; other site 349519002151 motif 2; other site 349519002152 motif 3; other site 349519002153 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 349519002154 anticodon binding site; other site 349519002155 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 349519002156 Protein of unknown function (DUF1361); Region: DUF1361; pfam07099 349519002157 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 349519002158 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 349519002159 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 349519002160 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 349519002161 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 349519002162 23S rRNA binding site [nucleotide binding]; other site 349519002163 L21 binding site [polypeptide binding]; other site 349519002164 L13 binding site [polypeptide binding]; other site 349519002165 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 349519002166 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 349519002167 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 349519002168 elongation factor Tu; Reviewed; Region: PRK00049 349519002169 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 349519002170 G1 box; other site 349519002171 GEF interaction site [polypeptide binding]; other site 349519002172 GTP/Mg2+ binding site [chemical binding]; other site 349519002173 Switch I region; other site 349519002174 G2 box; other site 349519002175 G3 box; other site 349519002176 Switch II region; other site 349519002177 G4 box; other site 349519002178 G5 box; other site 349519002179 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 349519002180 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 349519002181 Antibiotic Binding Site [chemical binding]; other site 349519002182 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 349519002183 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 349519002184 Walker A/P-loop; other site 349519002185 ATP binding site [chemical binding]; other site 349519002186 Q-loop/lid; other site 349519002187 ABC transporter signature motif; other site 349519002188 Walker B; other site 349519002189 D-loop; other site 349519002190 H-loop/switch region; other site 349519002191 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 349519002192 tetramer (dimer of dimers) interface [polypeptide binding]; other site 349519002193 active site 349519002194 dimer interface [polypeptide binding]; other site 349519002195 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 349519002196 Ligand Binding Site [chemical binding]; other site 349519002197 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 349519002198 active site 349519002199 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 349519002200 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 349519002201 active site 349519002202 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 349519002203 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 349519002204 HIGH motif; other site 349519002205 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 349519002206 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 349519002207 active site 349519002208 KMSKS motif; other site 349519002209 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 349519002210 tRNA binding surface [nucleotide binding]; other site 349519002211 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 349519002212 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 349519002213 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 349519002214 heat shock protein HtpX; Provisional; Region: PRK04897 349519002215 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK06843 349519002216 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 349519002217 active site 349519002218 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK06843 349519002219 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 349519002220 phosphate binding site [ion binding]; other site 349519002221 GMP synthase; Reviewed; Region: guaA; PRK00074 349519002222 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 349519002223 AMP/PPi binding site [chemical binding]; other site 349519002224 candidate oxyanion hole; other site 349519002225 catalytic triad [active] 349519002226 potential glutamine specificity residues [chemical binding]; other site 349519002227 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 349519002228 ATP Binding subdomain [chemical binding]; other site 349519002229 Dimerization subdomain; other site 349519002230 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; cl17626 349519002231 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 349519002232 Spc7 kinetochore protein; Region: Spc7; smart00787 349519002233 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 349519002234 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 349519002235 Walker A/P-loop; other site 349519002236 ATP binding site [chemical binding]; other site 349519002237 Q-loop/lid; other site 349519002238 ABC transporter signature motif; other site 349519002239 Walker B; other site 349519002240 D-loop; other site 349519002241 H-loop/switch region; other site 349519002242 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 349519002243 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 349519002244 ATP binding site [chemical binding]; other site 349519002245 Mg2+ binding site [ion binding]; other site 349519002246 G-X-G motif; other site 349519002247 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 349519002248 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 349519002249 active site 349519002250 phosphorylation site [posttranslational modification] 349519002251 intermolecular recognition site; other site 349519002252 dimerization interface [polypeptide binding]; other site 349519002253 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 349519002254 DNA binding site [nucleotide binding] 349519002255 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 349519002256 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 349519002257 Transglycosylase; Region: Transgly; pfam00912 349519002258 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 349519002259 hypothetical protein; Provisional; Region: PRK13660 349519002260 cell division protein GpsB; Provisional; Region: PRK14127 349519002261 DivIVA domain; Region: DivI1A_domain; TIGR03544 349519002262 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 349519002263 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 349519002264 substrate binding pocket [chemical binding]; other site 349519002265 membrane-bound complex binding site; other site 349519002266 hinge residues; other site 349519002267 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 349519002268 dimer interface [polypeptide binding]; other site 349519002269 conserved gate region; other site 349519002270 ABC-ATPase subunit interface; other site 349519002271 AIR carboxylase; Region: AIRC; pfam00731 349519002272 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 349519002273 ATP-grasp domain; Region: ATP-grasp; pfam02222 349519002274 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 349519002275 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 349519002276 ATP binding site [chemical binding]; other site 349519002277 active site 349519002278 substrate binding site [chemical binding]; other site 349519002279 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700 349519002280 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 349519002281 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 349519002282 putative active site [active] 349519002283 catalytic triad [active] 349519002284 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 349519002285 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 349519002286 dimerization interface [polypeptide binding]; other site 349519002287 ATP binding site [chemical binding]; other site 349519002288 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 349519002289 dimerization interface [polypeptide binding]; other site 349519002290 ATP binding site [chemical binding]; other site 349519002291 amidophosphoribosyltransferase; Provisional; Region: PRK07272 349519002292 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 349519002293 active site 349519002294 tetramer interface [polypeptide binding]; other site 349519002295 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 349519002296 active site 349519002297 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 349519002298 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 349519002299 dimerization interface [polypeptide binding]; other site 349519002300 putative ATP binding site [chemical binding]; other site 349519002301 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 349519002302 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 349519002303 active site 349519002304 substrate binding site [chemical binding]; other site 349519002305 cosubstrate binding site; other site 349519002306 catalytic site [active] 349519002307 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 349519002308 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 349519002309 purine monophosphate binding site [chemical binding]; other site 349519002310 dimer interface [polypeptide binding]; other site 349519002311 putative catalytic residues [active] 349519002312 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 349519002313 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 349519002314 putative active site [active] 349519002315 nucleotide binding site [chemical binding]; other site 349519002316 nudix motif; other site 349519002317 putative metal binding site [ion binding]; other site 349519002318 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 349519002319 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 349519002320 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 349519002321 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 349519002322 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 349519002323 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 349519002324 Potassium binding sites [ion binding]; other site 349519002325 Cesium cation binding sites [ion binding]; other site 349519002326 Predicted esterase [General function prediction only]; Region: COG0627 349519002327 S-formylglutathione hydrolase; Region: PLN02442 349519002328 Major Facilitator Superfamily; Region: MFS_1; pfam07690 349519002329 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 349519002330 putative substrate translocation pore; other site 349519002331 adenylosuccinate lyase; Provisional; Region: PRK07492 349519002332 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 349519002333 tetramer interface [polypeptide binding]; other site 349519002334 active site 349519002335 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 349519002336 active site 349519002337 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 349519002338 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 349519002339 homotetramer interface [polypeptide binding]; other site 349519002340 FMN binding site [chemical binding]; other site 349519002341 homodimer contacts [polypeptide binding]; other site 349519002342 putative active site [active] 349519002343 putative substrate binding site [chemical binding]; other site 349519002344 phosphomevalonate kinase, ERG8-type, Gram-positive branch; Region: Pmev_kin_Gr_pos; TIGR01220 349519002345 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 349519002346 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 349519002347 Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407 349519002348 diphosphomevalonate decarboxylase; Region: PLN02407 349519002349 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 349519002350 Domain of unknown function DUF20; Region: UPF0118; pfam01594 349519002351 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 349519002352 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 349519002353 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 349519002354 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 349519002355 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 349519002356 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 349519002357 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 349519002358 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 349519002359 active site 349519002360 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 349519002361 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 349519002362 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 349519002363 glutaminase active site [active] 349519002364 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 349519002365 dimer interface [polypeptide binding]; other site 349519002366 active site 349519002367 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 349519002368 dimer interface [polypeptide binding]; other site 349519002369 active site 349519002370 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14830 349519002371 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 349519002372 catalytic residue [active] 349519002373 putative FPP diphosphate binding site; other site 349519002374 putative FPP binding hydrophobic cleft; other site 349519002375 dimer interface [polypeptide binding]; other site 349519002376 putative IPP diphosphate binding site; other site 349519002377 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 349519002378 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 349519002379 RIP metalloprotease RseP; Region: TIGR00054 349519002380 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 349519002381 active site 349519002382 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 349519002383 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 349519002384 protein binding site [polypeptide binding]; other site 349519002385 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 349519002386 putative substrate binding region [chemical binding]; other site 349519002387 prolyl-tRNA synthetase; Provisional; Region: PRK09194 349519002388 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 349519002389 dimer interface [polypeptide binding]; other site 349519002390 motif 1; other site 349519002391 active site 349519002392 motif 2; other site 349519002393 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 349519002394 putative deacylase active site [active] 349519002395 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 349519002396 active site 349519002397 motif 3; other site 349519002398 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 349519002399 anticodon binding site; other site 349519002400 DNA polymerase III PolC; Validated; Region: polC; PRK00448 349519002401 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 349519002402 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 349519002403 generic binding surface II; other site 349519002404 generic binding surface I; other site 349519002405 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 349519002406 active site 349519002407 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 349519002408 active site 349519002409 catalytic site [active] 349519002410 substrate binding site [chemical binding]; other site 349519002411 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 349519002412 phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833 349519002413 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 349519002414 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 349519002415 substrate binding site [chemical binding]; other site 349519002416 dimer interface [polypeptide binding]; other site 349519002417 ATP binding site [chemical binding]; other site 349519002418 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 349519002419 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 349519002420 S-adenosylmethionine binding site [chemical binding]; other site 349519002421 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 349519002422 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 349519002423 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 349519002424 ligand binding site [chemical binding]; other site 349519002425 Putative amino acid metabolism; Region: DUF1831; pfam08866 349519002426 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 349519002427 catalytic core [active] 349519002428 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 349519002429 AAA domain; Region: AAA_30; pfam13604 349519002430 Family description; Region: UvrD_C_2; pfam13538 349519002431 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 349519002432 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 349519002433 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 349519002434 active site 349519002435 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 349519002436 active site 349519002437 catalytic triad [active] 349519002438 oxyanion hole [active] 349519002439 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 349519002440 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 349519002441 active site 349519002442 catalytic tetrad [active] 349519002443 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 349519002444 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cd00004 349519002445 active site 349519002446 catalytic site [active] 349519002447 mevalonate kinase; Region: mevalon_kin; TIGR00549 349519002448 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 349519002449 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 349519002450 active site 349519002451 catalytic site [active] 349519002452 substrate binding site [chemical binding]; other site 349519002453 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 349519002454 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 349519002455 aspartate aminotransferase; Provisional; Region: PRK05764 349519002456 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 349519002457 pyridoxal 5'-phosphate binding site [chemical binding]; other site 349519002458 homodimer interface [polypeptide binding]; other site 349519002459 catalytic residue [active] 349519002460 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 349519002461 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 349519002462 putative dimer interface [polypeptide binding]; other site 349519002463 putative anticodon binding site; other site 349519002464 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 349519002465 homodimer interface [polypeptide binding]; other site 349519002466 motif 1; other site 349519002467 motif 2; other site 349519002468 active site 349519002469 motif 3; other site 349519002470 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 349519002471 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 349519002472 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 349519002473 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 349519002474 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 349519002475 aromatic amino acid aminotransferase; Validated; Region: PRK07309 349519002476 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 349519002477 pyridoxal 5'-phosphate binding site [chemical binding]; other site 349519002478 homodimer interface [polypeptide binding]; other site 349519002479 catalytic residue [active] 349519002480 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 349519002481 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 349519002482 Coenzyme A binding pocket [chemical binding]; other site 349519002483 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 349519002484 dimer interface [polypeptide binding]; other site 349519002485 FMN binding site [chemical binding]; other site 349519002486 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 349519002487 amidase catalytic site [active] 349519002488 Zn binding residues [ion binding]; other site 349519002489 substrate binding site [chemical binding]; other site 349519002490 SH3-like domain; Region: SH3_8; pfam13457 349519002491 SH3-like domain; Region: SH3_8; pfam13457 349519002492 SH3-like domain; Region: SH3_8; pfam13457 349519002493 SH3-like domain; Region: SH3_8; pfam13457 349519002494 SH3-like domain; Region: SH3_8; pfam13457 349519002495 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 349519002496 Transcriptional regulators [Transcription]; Region: PurR; COG1609 349519002497 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 349519002498 DNA binding site [nucleotide binding] 349519002499 domain linker motif; other site 349519002500 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 349519002501 ligand binding site [chemical binding]; other site 349519002502 dimerization interface [polypeptide binding]; other site 349519002503 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 349519002504 Major Facilitator Superfamily; Region: MFS_1; pfam07690 349519002505 putative substrate translocation pore; other site 349519002506 maltose phosphorylase; Provisional; Region: PRK13807 349519002507 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 349519002508 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 349519002509 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 349519002510 beta-phosphoglucomutase; Region: bPGM; TIGR01990 349519002511 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 349519002512 motif II; other site 349519002513 Transcriptional regulators [Transcription]; Region: PurR; COG1609 349519002514 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 349519002515 DNA binding site [nucleotide binding] 349519002516 domain linker motif; other site 349519002517 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 349519002518 dimerization interface [polypeptide binding]; other site 349519002519 ligand binding site [chemical binding]; other site 349519002520 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 349519002521 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 349519002522 Ca binding site [ion binding]; other site 349519002523 active site 349519002524 catalytic site [active] 349519002525 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 349519002526 putative substrate translocation pore; other site 349519002527 Major Facilitator Superfamily; Region: MFS_1; pfam07690 349519002528 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 349519002529 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 349519002530 Ca binding site [ion binding]; other site 349519002531 active site 349519002532 catalytic site [active] 349519002533 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706 349519002534 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 349519002535 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 349519002536 dimer interface [polypeptide binding]; other site 349519002537 motif 1; other site 349519002538 active site 349519002539 motif 2; other site 349519002540 motif 3; other site 349519002541 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 349519002542 anticodon binding site; other site 349519002543 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 349519002544 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 349519002545 dimer interface [polypeptide binding]; other site 349519002546 anticodon binding site; other site 349519002547 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 349519002548 motif 1; other site 349519002549 dimer interface [polypeptide binding]; other site 349519002550 active site 349519002551 motif 2; other site 349519002552 GAD domain; Region: GAD; pfam02938 349519002553 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 349519002554 active site 349519002555 motif 3; other site 349519002556 Uncharacterized conserved protein [Function unknown]; Region: COG1284 349519002557 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 349519002558 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 349519002559 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 349519002560 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 349519002561 DRTGG domain; Region: DRTGG; pfam07085 349519002562 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 349519002563 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 349519002564 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 349519002565 putative substrate translocation pore; other site 349519002566 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 349519002567 Yqey-like protein; Region: YqeY; pfam09424 349519002568 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 349519002569 S1 domain; Region: S1_2; pfam13509 349519002570 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 349519002571 RNA binding site [nucleotide binding]; other site 349519002572 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 349519002573 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 349519002574 active site 349519002575 Int/Topo IB signature motif; other site 349519002576 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 349519002577 segregation and condensation protein B; Reviewed; Region: scpB; PRK00135 349519002578 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 349519002579 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 349519002580 RNA binding surface [nucleotide binding]; other site 349519002581 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 349519002582 active site 349519002583 Predicted membrane protein [Function unknown]; Region: COG3601 349519002584 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 349519002585 cytidylate kinase; Provisional; Region: cmk; PRK00023 349519002586 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 349519002587 CMP-binding site; other site 349519002588 The sites determining sugar specificity; other site 349519002589 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 349519002590 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 349519002591 RNA binding site [nucleotide binding]; other site 349519002592 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 349519002593 RNA binding site [nucleotide binding]; other site 349519002594 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 349519002595 RNA binding site [nucleotide binding]; other site 349519002596 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 349519002597 RNA binding site [nucleotide binding]; other site 349519002598 GTP-binding protein Der; Reviewed; Region: PRK00093 349519002599 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 349519002600 G1 box; other site 349519002601 GTP/Mg2+ binding site [chemical binding]; other site 349519002602 Switch I region; other site 349519002603 G2 box; other site 349519002604 Switch II region; other site 349519002605 G3 box; other site 349519002606 G4 box; other site 349519002607 G5 box; other site 349519002608 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 349519002609 G1 box; other site 349519002610 GTP/Mg2+ binding site [chemical binding]; other site 349519002611 Switch I region; other site 349519002612 G2 box; other site 349519002613 G3 box; other site 349519002614 Switch II region; other site 349519002615 G4 box; other site 349519002616 G5 box; other site 349519002617 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 349519002618 IHF dimer interface [polypeptide binding]; other site 349519002619 IHF - DNA interface [nucleotide binding]; other site 349519002620 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 349519002621 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 349519002622 active site 349519002623 catalytic tetrad [active] 349519002624 CsbD-like; Region: CsbD; pfam05532 349519002625 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 349519002626 binding surface 349519002627 TPR motif; other site 349519002628 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 349519002629 binding surface 349519002630 TPR motif; other site 349519002631 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 349519002632 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 349519002633 binding surface 349519002634 TPR motif; other site 349519002635 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 349519002636 binding surface 349519002637 TPR motif; other site 349519002638 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 349519002639 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 349519002640 active site 349519002641 NTP binding site [chemical binding]; other site 349519002642 metal binding triad [ion binding]; metal-binding site 349519002643 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 349519002644 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 349519002645 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 349519002646 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 349519002647 folate binding site [chemical binding]; other site 349519002648 NADP+ binding site [chemical binding]; other site 349519002649 EDD domain protein, DegV family; Region: DegV; TIGR00762 349519002650 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 349519002651 NH_3: A subgroup of nucleoside hydrolases. This group contains eukaryotic and bacterial proteins similar to nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes...; Region: nuc_hydro_3; cd02653 349519002652 active site 349519002653 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 349519002654 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 349519002655 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 349519002656 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 349519002657 TPP-binding site [chemical binding]; other site 349519002658 dimer interface [polypeptide binding]; other site 349519002659 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 349519002660 PYR/PP interface [polypeptide binding]; other site 349519002661 dimer interface [polypeptide binding]; other site 349519002662 TPP binding site [chemical binding]; other site 349519002663 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 349519002664 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 349519002665 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 349519002666 shikimate binding site; other site 349519002667 NAD(P) binding site [chemical binding]; other site 349519002668 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; cl17225 349519002669 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 349519002670 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 349519002671 active site 349519002672 dimer interface [polypeptide binding]; other site 349519002673 metal binding site [ion binding]; metal-binding site 349519002674 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 349519002675 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 349519002676 Tetramer interface [polypeptide binding]; other site 349519002677 active site 349519002678 FMN-binding site [chemical binding]; other site 349519002679 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 349519002680 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 349519002681 hinge; other site 349519002682 active site 349519002683 prephenate dehydrogenase; Validated; Region: PRK08507 349519002684 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 349519002685 shikimate kinase; Reviewed; Region: aroK; PRK00131 349519002686 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 349519002687 ADP binding site [chemical binding]; other site 349519002688 magnesium binding site [ion binding]; other site 349519002689 putative shikimate binding site; other site 349519002690 Chorismate mutase type II; Region: CM_2; smart00830 349519002691 Prephenate dehydratase; Region: PDT; pfam00800 349519002692 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 349519002693 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 349519002694 active site 349519002695 catalytic residue [active] 349519002696 dimer interface [polypeptide binding]; other site 349519002697 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 349519002698 DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587 349519002699 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 349519002700 active site 349519002701 PHP Thumb interface [polypeptide binding]; other site 349519002702 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 349519002703 generic binding surface II; other site 349519002704 generic binding surface I; other site 349519002705 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 349519002706 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 349519002707 domain interfaces; other site 349519002708 active site 349519002709 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 349519002710 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 349519002711 PhoH-like protein; Region: PhoH; pfam02562 349519002712 metal-binding heat shock protein; Provisional; Region: PRK00016 349519002713 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219 349519002714 GTPase Era; Reviewed; Region: era; PRK00089 349519002715 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 349519002716 G1 box; other site 349519002717 GTP/Mg2+ binding site [chemical binding]; other site 349519002718 Switch I region; other site 349519002719 G2 box; other site 349519002720 Switch II region; other site 349519002721 G3 box; other site 349519002722 G4 box; other site 349519002723 G5 box; other site 349519002724 KH domain; Region: KH_2; pfam07650 349519002725 DNA repair protein RecO; Region: reco; TIGR00613 349519002726 Recombination protein O N terminal; Region: RecO_N; pfam11967 349519002727 Recombination protein O C terminal; Region: RecO_C; pfam02565 349519002728 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 349519002729 active site 349519002730 homotetramer interface [polypeptide binding]; other site 349519002731 homodimer interface [polypeptide binding]; other site 349519002732 CAAX protease self-immunity; Region: Abi; pfam02517 349519002733 aspartate kinase; Reviewed; Region: PRK09034 349519002734 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 349519002735 putative catalytic residues [active] 349519002736 putative nucleotide binding site [chemical binding]; other site 349519002737 putative aspartate binding site [chemical binding]; other site 349519002738 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 349519002739 allosteric regulatory residue; other site 349519002740 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 349519002741 homoserine kinase; Provisional; Region: PRK01212 349519002742 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 349519002743 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 349519002744 homoserine dehydrogenase; Provisional; Region: PRK06349 349519002745 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 349519002746 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 349519002747 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 349519002748 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 349519002749 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 349519002750 pyridoxal 5'-phosphate binding site [chemical binding]; other site 349519002751 catalytic residue [active] 349519002752 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 349519002753 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 349519002754 dimer interface [polypeptide binding]; other site 349519002755 active site 349519002756 glycine-pyridoxal phosphate binding site [chemical binding]; other site 349519002757 folate binding site [chemical binding]; other site 349519002758 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 349519002759 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 349519002760 Bacterial SH3 domain; Region: SH3_3; pfam08239 349519002761 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 349519002762 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 349519002763 active site 349519002764 metal binding site [ion binding]; metal-binding site 349519002765 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 349519002766 propionate/acetate kinase; Provisional; Region: PRK12379 349519002767 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 349519002768 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 349519002769 Walker A/P-loop; other site 349519002770 ATP binding site [chemical binding]; other site 349519002771 Q-loop/lid; other site 349519002772 ABC transporter signature motif; other site 349519002773 Walker B; other site 349519002774 D-loop; other site 349519002775 H-loop/switch region; other site 349519002776 ABC transporter; Region: ABC_tran_2; pfam12848 349519002777 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 349519002778 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 349519002779 DNA protecting protein DprA; Region: dprA; TIGR00732 349519002780 DNA topoisomerase I; Validated; Region: PRK05582 349519002781 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 349519002782 active site 349519002783 interdomain interaction site; other site 349519002784 putative metal-binding site [ion binding]; other site 349519002785 nucleotide binding site [chemical binding]; other site 349519002786 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 349519002787 domain I; other site 349519002788 DNA binding groove [nucleotide binding] 349519002789 phosphate binding site [ion binding]; other site 349519002790 domain II; other site 349519002791 domain III; other site 349519002792 nucleotide binding site [chemical binding]; other site 349519002793 catalytic site [active] 349519002794 domain IV; other site 349519002795 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 349519002796 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 349519002797 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 349519002798 active pocket/dimerization site; other site 349519002799 active site 349519002800 phosphorylation site [posttranslational modification] 349519002801 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cl00021 349519002802 active site 349519002803 phosphorylation site [posttranslational modification] 349519002804 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 349519002805 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 349519002806 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 349519002807 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 349519002808 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 349519002809 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 349519002810 pyridoxal 5'-phosphate binding site [chemical binding]; other site 349519002811 homodimer interface [polypeptide binding]; other site 349519002812 catalytic residue [active] 349519002813 Transcriptional regulator [Transcription]; Region: LysR; COG0583 349519002814 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 349519002815 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 349519002816 dimerization interface [polypeptide binding]; other site 349519002817 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 349519002818 2-hydroxycyclohexanecarboxyl-CoA dehydrogenase; Region: benzo_BadH; TIGR03206 349519002819 NAD(P) binding site [chemical binding]; other site 349519002820 active site 349519002821 DNA primase; Validated; Region: dnaG; PRK05667 349519002822 CHC2 zinc finger; Region: zf-CHC2; cl17510 349519002823 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 349519002824 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 349519002825 active site 349519002826 metal binding site [ion binding]; metal-binding site 349519002827 interdomain interaction site; other site 349519002828 HeH/LEM domain; Region: HeH; pfam12949 349519002829 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 349519002830 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 349519002831 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 349519002832 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 349519002833 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 349519002834 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 349519002835 DNA binding residues [nucleotide binding] 349519002836 QueT transporter; Region: QueT; pfam06177 349519002837 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK06550 349519002838 classical (c) SDRs; Region: SDR_c; cd05233 349519002839 NAD(P) binding site [chemical binding]; other site 349519002840 active site 349519002841 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033 349519002842 putative uracil binding site [chemical binding]; other site 349519002843 putative active site [active] 349519002844 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 349519002845 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 349519002846 transmembrane helices; other site 349519002847 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 349519002848 Transcriptional regulator [Transcription]; Region: LysR; COG0583 349519002849 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 349519002850 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 349519002851 dimerization interface [polypeptide binding]; other site 349519002852 malate dehydrogenase; Provisional; Region: PRK13529 349519002853 Malic enzyme, N-terminal domain; Region: malic; pfam00390 349519002854 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 349519002855 NAD(P) binding site [chemical binding]; other site 349519002856 2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390 349519002857 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 349519002858 Predicted flavoprotein [General function prediction only]; Region: COG0431 349519002859 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 349519002860 non-specific DNA binding site [nucleotide binding]; other site 349519002861 salt bridge; other site 349519002862 sequence-specific DNA binding site [nucleotide binding]; other site 349519002863 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 349519002864 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 349519002865 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 349519002866 putative NAD(P) binding site [chemical binding]; other site 349519002867 catalytic Zn binding site [ion binding]; other site 349519002868 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 349519002869 catalytic residues [active] 349519002870 dimer interface [polypeptide binding]; other site 349519002871 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 349519002872 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 349519002873 Helix-turn-helix domain; Region: HTH_38; pfam13936 349519002874 Integrase core domain; Region: rve; pfam00665 349519002875 K+ potassium transporter; Region: K_trans; pfam02705 349519002876 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 349519002877 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 349519002878 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 349519002879 catalytic motif [active] 349519002880 Zn binding site [ion binding]; other site 349519002881 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 349519002882 RibD C-terminal domain; Region: RibD_C; pfam01872 349519002883 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 349519002884 Lumazine binding domain; Region: Lum_binding; pfam00677 349519002885 Lumazine binding domain; Region: Lum_binding; pfam00677 349519002886 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 349519002887 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 349519002888 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 349519002889 dimerization interface [polypeptide binding]; other site 349519002890 active site 349519002891 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 349519002892 homopentamer interface [polypeptide binding]; other site 349519002893 active site 349519002894 AAA-like domain; Region: AAA_10; pfam12846 349519002895 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 349519002896 ApbE family; Region: ApbE; pfam02424 349519002897 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 349519002898 Predicted flavoprotein [General function prediction only]; Region: COG0431 349519002899 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 349519002900 Predicted flavoprotein [General function prediction only]; Region: COG0431 349519002901 PAS domain; Region: PAS_10; pfam13596 349519002902 methionine sulfoxide reductase B; Provisional; Region: PRK00222 349519002903 SelR domain; Region: SelR; pfam01641 349519002904 Beta-lactamase; Region: Beta-lactamase; pfam00144 349519002905 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 349519002906 Predicted membrane protein [Function unknown]; Region: COG2261 349519002907 Small integral membrane protein (DUF2273); Region: DUF2273; pfam10031 349519002908 Asp23 family; Region: Asp23; cl00574 349519002909 MarR family; Region: MarR; pfam01047 349519002910 MarR family; Region: MarR_2; cl17246 349519002911 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 349519002912 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 349519002913 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 349519002914 putative dimer interface [polypeptide binding]; other site 349519002915 catalytic triad [active] 349519002916 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 349519002917 SH3-like domain; Region: SH3_8; pfam13457 349519002918 conserved hypothetical integral membrane protein; Region: TIGR03766 349519002919 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 349519002920 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 349519002921 Coenzyme A binding pocket [chemical binding]; other site 349519002922 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 349519002923 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 349519002924 putative substrate translocation pore; other site 349519002925 Sugar efflux transporter for intercellular exchange; Region: MtN3_slv; pfam03083 349519002926 oxidoreductase; Provisional; Region: PRK06128 349519002927 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 349519002928 NAD(P) binding site [chemical binding]; other site 349519002929 active site 349519002930 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 349519002931 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 349519002932 active site 349519002933 catalytic tetrad [active] 349519002934 phytoene desaturase; Region: crtI_fam; TIGR02734 349519002935 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 349519002936 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 349519002937 active site lid residues [active] 349519002938 substrate binding pocket [chemical binding]; other site 349519002939 catalytic residues [active] 349519002940 substrate-Mg2+ binding site; other site 349519002941 aspartate-rich region 1; other site 349519002942 aspartate-rich region 2; other site 349519002943 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 349519002944 metal binding site [ion binding]; metal-binding site 349519002945 Predicted membrane protein [Function unknown]; Region: COG2261 349519002946 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 349519002947 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 349519002948 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 349519002949 DNA-binding site [nucleotide binding]; DNA binding site 349519002950 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 349519002951 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 349519002952 beta-galactosidase; Region: BGL; TIGR03356 349519002953 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 349519002954 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 349519002955 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 349519002956 active site 349519002957 P-loop; other site 349519002958 phosphorylation site [posttranslational modification] 349519002959 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 349519002960 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 349519002961 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 349519002962 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 349519002963 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 349519002964 Ca binding site [ion binding]; other site 349519002965 active site 349519002966 catalytic site [active] 349519002967 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 349519002968 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 349519002969 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 349519002970 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 349519002971 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 349519002972 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 349519002973 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 349519002974 motif II; other site 349519002975 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 349519002976 DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402 349519002977 ligand binding site [chemical binding]; other site 349519002978 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 349519002979 Domain of unknown function (DUF4356); Region: DUF4356; pfam14266 349519002980 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 349519002981 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 349519002982 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 349519002983 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588 349519002984 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 349519002985 metal binding site [ion binding]; metal-binding site 349519002986 dimer interface [polypeptide binding]; other site 349519002987 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 349519002988 putative active site [active] 349519002989 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 349519002990 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; pfam10110 349519002991 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 349519002992 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 349519002993 putative active site [active] 349519002994 catalytic site [active] 349519002995 putative metal binding site [ion binding]; other site 349519002996 galactokinase; Provisional; Region: PRK05322 349519002997 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 349519002998 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 349519002999 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 349519003000 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 349519003001 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 349519003002 Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744 349519003003 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 349519003004 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 349519003005 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 349519003006 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 349519003007 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 349519003008 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 349519003009 Beta galactosidase small chain; Region: Bgal_small_N; smart01038 349519003010 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 349519003011 active site 349519003012 catalytic residues [active] 349519003013 Transcriptional regulators [Transcription]; Region: PurR; COG1609 349519003014 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 349519003015 DNA binding site [nucleotide binding] 349519003016 domain linker motif; other site 349519003017 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 349519003018 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 349519003019 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 349519003020 putative substrate translocation pore; other site 349519003021 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 349519003022 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 349519003023 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 349519003024 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 349519003025 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 349519003026 Protein of unknown function (DUF3278); Region: DUF3278; pfam11683 349519003027 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 349519003028 putative substrate translocation pore; other site 349519003029 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 349519003030 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 349519003031 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 349519003032 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK06079 349519003033 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 349519003034 NAD(P) binding site [chemical binding]; other site 349519003035 active site 349519003036 Protein of unknown function (DUF1349); Region: DUF1349; pfam07081 349519003037 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 349519003038 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 349519003039 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 349519003040 DNA polymerase IV; Reviewed; Region: PRK03103 349519003041 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 349519003042 active site 349519003043 DNA binding site [nucleotide binding] 349519003044 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 349519003045 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 349519003046 putative active site [active] 349519003047 Inactive transposase derivative, IS30 family COG2826L 349519003048 AAA domain; Region: AAA_21; pfam13304 349519003049 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 349519003050 Q-loop/lid; other site 349519003051 ABC transporter signature motif; other site 349519003052 Walker B; other site 349519003053 D-loop; other site 349519003054 H-loop/switch region; other site 349519003055 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 349519003056 AAA domain; Region: AAA_21; pfam13304 349519003057 ABC transporter signature motif; other site 349519003058 Walker B; other site 349519003059 D-loop; other site 349519003060 H-loop/switch region; other site 349519003061 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 349519003062 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 349519003063 Walker A/P-loop; other site 349519003064 ATP binding site [chemical binding]; other site 349519003065 Q-loop/lid; other site 349519003066 ABC transporter signature motif; other site 349519003067 Walker B; other site 349519003068 D-loop; other site 349519003069 H-loop/switch region; other site 349519003070 Conjugative transposon protein TcpC; Region: TpcC; pfam12642 349519003071 Protein of unknown function (DUF2089); Region: DUF2089; pfam09862 349519003072 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 349519003073 CHAP domain; Region: CHAP; pfam05257 349519003074 AAA-like domain; Region: AAA_10; pfam12846 349519003075 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 349519003076 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 349519003077 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 349519003078 non-specific DNA binding site [nucleotide binding]; other site 349519003079 salt bridge; other site 349519003080 sequence-specific DNA binding site [nucleotide binding]; other site 349519003081 Replication initiation factor; Region: Rep_trans; pfam02486 349519003082 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 349519003083 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 349519003084 Cl- selectivity filter; other site 349519003085 Cl- binding residues [ion binding]; other site 349519003086 pore gating glutamate residue; other site 349519003087 dimer interface [polypeptide binding]; other site 349519003088 H+/Cl- coupling transport residue; other site 349519003089 TrkA-C domain; Region: TrkA_C; pfam02080 349519003090 Inactive transposase derivative, IS30 family COG2826L 349519003091 Cation transport protein; Region: TrkH; cl17365 349519003092 Domain of unknown function (DUF389); Region: DUF389; pfam04087 349519003093 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 349519003094 Integrase core domain; Region: rve; pfam00665 349519003095 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 349519003096 Helix-turn-helix domain; Region: HTH_38; pfam13936 349519003097 Integrase core domain; Region: rve; pfam00665 349519003098 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 349519003099 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 349519003100 ATP binding site [chemical binding]; other site 349519003101 putative Mg++ binding site [ion binding]; other site 349519003102 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 349519003103 DNA methylase; Region: N6_N4_Mtase; pfam01555 349519003104 Cell fusion glycoprotein K; Region: Fusion_gly_K; cl17292 349519003105 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 349519003106 non-specific DNA binding site [nucleotide binding]; other site 349519003107 salt bridge; other site 349519003108 sequence-specific DNA binding site [nucleotide binding]; other site 349519003109 Replication initiation factor; Region: Rep_trans; pfam02486 349519003110 Abortive infection C-terminus; Region: Abi_C; pfam14355 349519003111 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 349519003112 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 349519003113 AAA-like domain; Region: AAA_10; pfam12846 349519003114 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 349519003115 CHAP domain; Region: CHAP; pfam05257 349519003116 Conjugative transposon protein TcpC; Region: TpcC; pfam12642 349519003117 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 349519003118 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 349519003119 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 349519003120 HsdM N-terminal domain; Region: HsdM_N; pfam12161 349519003121 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 349519003122 Methyltransferase domain; Region: Methyltransf_26; pfam13659 349519003123 type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348 349519003124 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 349519003125 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 349519003126 ATP binding site [chemical binding]; other site 349519003127 putative Mg++ binding site [ion binding]; other site 349519003128 Type I restriction and modification enzyme - subunit R C terminal; Region: EcoR124_C; pfam12008 349519003129 CAAX protease self-immunity; Region: Abi; pfam02517 349519003130 Uncharacterized conserved protein (DUF2075); Region: DUF2075; pfam09848 349519003131 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 349519003132 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 349519003133 Coenzyme A binding pocket [chemical binding]; other site 349519003134 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 349519003135 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 349519003136 Uncharacterized conserved protein [Function unknown]; Region: COG0393 349519003137 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 349519003138 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 349519003139 Coenzyme A binding pocket [chemical binding]; other site 349519003140 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 349519003141 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 349519003142 DNA binding residues [nucleotide binding] 349519003143 NADH-ubiquinone oxidoreductase ASHI subunit (CI-ASHI or NDUFB8); Region: NDUF_B8; pfam05821 349519003144 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 349519003145 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 349519003146 Ligand binding site; other site 349519003147 Putative Catalytic site; other site 349519003148 DXD motif; other site 349519003149 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 349519003150 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 349519003151 active site 349519003152 Predicted membrane protein [Function unknown]; Region: COG2246 349519003153 GtrA-like protein; Region: GtrA; pfam04138 349519003154 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 349519003155 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 349519003156 substrate binding site; other site 349519003157 tetramer interface; other site 349519003158 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 349519003159 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 349519003160 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 349519003161 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 349519003162 Walker A/P-loop; other site 349519003163 ATP binding site [chemical binding]; other site 349519003164 Q-loop/lid; other site 349519003165 ABC transporter signature motif; other site 349519003166 Walker B; other site 349519003167 D-loop; other site 349519003168 H-loop/switch region; other site 349519003169 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 349519003170 MarR family; Region: MarR_2; pfam12802 349519003171 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 349519003172 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 349519003173 Walker A/P-loop; other site 349519003174 ATP binding site [chemical binding]; other site 349519003175 Q-loop/lid; other site 349519003176 ABC transporter signature motif; other site 349519003177 Walker B; other site 349519003178 D-loop; other site 349519003179 H-loop/switch region; other site 349519003180 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 349519003181 FtsX-like permease family; Region: FtsX; pfam02687 349519003182 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 349519003183 Rrf2 family protein; Region: rrf2_super; TIGR00738 349519003184 Transcriptional regulator; Region: Rrf2; pfam02082 349519003185 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 349519003186 NADH(P)-binding; Region: NAD_binding_10; pfam13460 349519003187 NAD(P) binding site [chemical binding]; other site 349519003188 active site 349519003189 D-lactate dehydrogenase; Provisional; Region: PRK11183 349519003190 FAD binding domain; Region: FAD_binding_4; pfam01565 349519003191 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 349519003192 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 349519003193 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 349519003194 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 349519003195 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 349519003196 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 349519003197 S-adenosylmethionine binding site [chemical binding]; other site 349519003198 Pectate lyase [Carbohydrate transport and metabolism]; Region: PelB; COG3866 349519003199 Amb_all domain; Region: Amb_all; smart00656 349519003200 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 349519003201 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; cl17295 349519003202 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 349519003203 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 349519003204 Protein of unknown function, DUF606; Region: DUF606; pfam04657 349519003205 Protein of unknown function, DUF606; Region: DUF606; pfam04657 349519003206 Domain of unknown function DUF77; Region: DUF77; pfam01910 349519003207 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 349519003208 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 349519003209 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 349519003210 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 349519003211 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 349519003212 ligand binding site [chemical binding]; other site 349519003213 flexible hinge region; other site 349519003214 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 349519003215 putative switch regulator; other site 349519003216 non-specific DNA interactions [nucleotide binding]; other site 349519003217 DNA binding site [nucleotide binding] 349519003218 sequence specific DNA binding site [nucleotide binding]; other site 349519003219 putative cAMP binding site [chemical binding]; other site 349519003220 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 349519003221 RNA/DNA hybrid binding site [nucleotide binding]; other site 349519003222 active site 349519003223 ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596 349519003224 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 349519003225 GTP/Mg2+ binding site [chemical binding]; other site 349519003226 G4 box; other site 349519003227 G5 box; other site 349519003228 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 349519003229 G1 box; other site 349519003230 G1 box; other site 349519003231 GTP/Mg2+ binding site [chemical binding]; other site 349519003232 Switch I region; other site 349519003233 G2 box; other site 349519003234 G2 box; other site 349519003235 G3 box; other site 349519003236 G3 box; other site 349519003237 Switch II region; other site 349519003238 Switch II region; other site 349519003239 G4 box; other site 349519003240 hypothetical protein; Provisional; Region: PRK13672 349519003241 Uncharacterized protein conserved in bacteria (DUF2140); Region: DUF2140; pfam09911 349519003242 Flagellar basal body-associated protein FliL; Region: FliL; cl00681 349519003243 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 349519003244 active site 349519003245 catalytic triad [active] 349519003246 oxyanion hole [active] 349519003247 peptidase T; Region: peptidase-T; TIGR01882 349519003248 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 349519003249 metal binding site [ion binding]; metal-binding site 349519003250 dimer interface [polypeptide binding]; other site 349519003251 Uncharacterized conserved protein [Function unknown]; Region: COG0327 349519003252 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 349519003253 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 349519003254 Family of unknown function (DUF633); Region: DUF633; pfam04816 349519003255 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 349519003256 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 349519003257 metal binding site [ion binding]; metal-binding site 349519003258 substrate binding pocket [chemical binding]; other site 349519003259 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 349519003260 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 349519003261 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 349519003262 dimer interface [polypeptide binding]; other site 349519003263 tetramer interface [polypeptide binding]; other site 349519003264 PYR/PP interface [polypeptide binding]; other site 349519003265 TPP binding site [chemical binding]; other site 349519003266 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 349519003267 TPP-binding site; other site 349519003268 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 349519003269 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 349519003270 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; pfam07155 349519003271 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 349519003272 dimer interface [polypeptide binding]; other site 349519003273 substrate binding site [chemical binding]; other site 349519003274 ATP binding site [chemical binding]; other site 349519003275 Uncharacterized conserved protein [Function unknown]; Region: COG1284 349519003276 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 349519003277 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 349519003278 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 349519003279 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 349519003280 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 349519003281 Coenzyme A binding pocket [chemical binding]; other site 349519003282 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 349519003283 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 349519003284 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 349519003285 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 349519003286 RNA binding site [nucleotide binding]; other site 349519003287 transcriptional antiterminator BglG; Provisional; Region: PRK09772 349519003288 CAT RNA binding domain; Region: CAT_RBD; smart01061 349519003289 PRD domain; Region: PRD; pfam00874 349519003290 PRD domain; Region: PRD; pfam00874 349519003291 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 349519003292 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 349519003293 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 349519003294 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 349519003295 active site turn [active] 349519003296 phosphorylation site [posttranslational modification] 349519003297 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 349519003298 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 349519003299 HPr interaction site; other site 349519003300 glycerol kinase (GK) interaction site [polypeptide binding]; other site 349519003301 active site 349519003302 phosphorylation site [posttranslational modification] 349519003303 dihydropteroate synthase; Region: DHPS; TIGR01496 349519003304 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 349519003305 substrate binding pocket [chemical binding]; other site 349519003306 dimer interface [polypeptide binding]; other site 349519003307 inhibitor binding site; inhibition site 349519003308 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 349519003309 active site 349519003310 dimerization interface [polypeptide binding]; other site 349519003311 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 349519003312 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 349519003313 GTP cyclohydrolase I; Provisional; Region: PLN03044 349519003314 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 349519003315 active site 349519003316 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 349519003317 catalytic center binding site [active] 349519003318 ATP binding site [chemical binding]; other site 349519003319 Dihydroneopterin aldolase [Coenzyme metabolism]; Region: FolB; COG1539 349519003320 active site 349519003321 Nicotinamide mononucleotide transporter; Region: NMN_transporter; cl01256 349519003322 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 349519003323 active site 349519003324 catalytic residues [active] 349519003325 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 349519003326 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 349519003327 active site 349519003328 DNA binding site [nucleotide binding] 349519003329 Int/Topo IB signature motif; other site 349519003330 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 349519003331 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 349519003332 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 349519003333 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 349519003334 dimer interface [polypeptide binding]; other site 349519003335 active site 349519003336 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 349519003337 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 349519003338 Walker A/P-loop; other site 349519003339 ATP binding site [chemical binding]; other site 349519003340 ABC transporter signature motif; other site 349519003341 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 349519003342 Walker B; other site 349519003343 D-loop; other site 349519003344 ABC transporter; Region: ABC_tran_2; pfam12848 349519003345 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 349519003346 V-type ATP synthase subunit I; Validated; Region: PRK05771 349519003347 RNA methyltransferase, RsmE family; Region: TIGR00046 349519003348 RNA methyltransferase; Region: Methyltrans_RNA; pfam04452 349519003349 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 349519003350 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 349519003351 S-adenosylmethionine binding site [chemical binding]; other site 349519003352 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 349519003353 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 349519003354 putative NAD(P) binding site [chemical binding]; other site 349519003355 dimer interface [polypeptide binding]; other site 349519003356 GTP-binding protein LepA; Provisional; Region: PRK05433 349519003357 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 349519003358 G1 box; other site 349519003359 putative GEF interaction site [polypeptide binding]; other site 349519003360 GTP/Mg2+ binding site [chemical binding]; other site 349519003361 Switch I region; other site 349519003362 G2 box; other site 349519003363 G3 box; other site 349519003364 Switch II region; other site 349519003365 G4 box; other site 349519003366 G5 box; other site 349519003367 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 349519003368 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 349519003369 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 349519003370 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 349519003371 EamA-like transporter family; Region: EamA; pfam00892 349519003372 putative oxidoreductase; Provisional; Region: PRK10206 349519003373 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 349519003374 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 349519003375 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 349519003376 glycyl-tRNA synthetase subunit alpha; Validated; Region: glyQ; PRK09348 349519003377 motif 1; other site 349519003378 dimer interface [polypeptide binding]; other site 349519003379 active site 349519003380 motif 2; other site 349519003381 motif 3; other site 349519003382 ribosome recycling factor; Reviewed; Region: frr; PRK00083 349519003383 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 349519003384 hinge region; other site 349519003385 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 349519003386 putative nucleotide binding site [chemical binding]; other site 349519003387 uridine monophosphate binding site [chemical binding]; other site 349519003388 homohexameric interface [polypeptide binding]; other site 349519003389 elongation factor Ts; Provisional; Region: tsf; PRK09377 349519003390 UBA/TS-N domain; Region: UBA; pfam00627 349519003391 Elongation factor TS; Region: EF_TS; pfam00889 349519003392 Elongation factor TS; Region: EF_TS; pfam00889 349519003393 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 349519003394 rRNA interaction site [nucleotide binding]; other site 349519003395 S8 interaction site; other site 349519003396 putative laminin-1 binding site; other site 349519003397 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 349519003398 GIY-YIG motif/motif A; other site 349519003399 putative active site [active] 349519003400 putative metal binding site [ion binding]; other site 349519003401 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 349519003402 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 349519003403 S-adenosylmethionine binding site [chemical binding]; other site 349519003404 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 349519003405 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 349519003406 putative acyl-acceptor binding pocket; other site 349519003407 LexA repressor; Validated; Region: PRK00215 349519003408 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 349519003409 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 349519003410 Catalytic site [active] 349519003411 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 349519003412 active site 349519003413 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 349519003414 active site 349519003415 dimer interface [polypeptide binding]; other site 349519003416 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 349519003417 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 349519003418 heterodimer interface [polypeptide binding]; other site 349519003419 active site 349519003420 FMN binding site [chemical binding]; other site 349519003421 homodimer interface [polypeptide binding]; other site 349519003422 substrate binding site [chemical binding]; other site 349519003423 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 349519003424 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 349519003425 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 349519003426 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 349519003427 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 349519003428 ATP-grasp domain; Region: ATP-grasp_4; cl17255 349519003429 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 349519003430 IMP binding site; other site 349519003431 dimer interface [polypeptide binding]; other site 349519003432 interdomain contacts; other site 349519003433 partial ornithine binding site; other site 349519003434 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 349519003435 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 349519003436 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 349519003437 catalytic site [active] 349519003438 subunit interface [polypeptide binding]; other site 349519003439 dihydroorotase; Validated; Region: pyrC; PRK09357 349519003440 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 349519003441 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 349519003442 active site 349519003443 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 349519003444 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 349519003445 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 349519003446 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 349519003447 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 349519003448 Catalytic site [active] 349519003449 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 349519003450 Protein of unknown function (DUF964); Region: DUF964; cl01483 349519003451 Transglycosylase; Region: Transgly; pfam00912 349519003452 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 349519003453 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 349519003454 Arginine repressor [Transcription]; Region: ArgR; COG1438 349519003455 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 349519003456 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 349519003457 arginyl-tRNA synthetase; Reviewed; Region: PRK12451 349519003458 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 349519003459 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 349519003460 active site 349519003461 HIGH motif; other site 349519003462 KMSK motif region; other site 349519003463 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 349519003464 tRNA binding surface [nucleotide binding]; other site 349519003465 anticodon binding site; other site 349519003466 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 349519003467 Flavoprotein; Region: Flavoprotein; pfam02441 349519003468 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 349519003469 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 349519003470 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 349519003471 HicB family; Region: HicB; pfam05534 349519003472 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 349519003473 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 349519003474 Soluble P-type ATPase [General function prediction only]; Region: COG4087 349519003475 UDP-N-acetylmuramoylalanyl-D-glutamate--L-lysine ligase; Provisional; Region: PRK14022 349519003476 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 349519003477 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 349519003478 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 349519003479 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 349519003480 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 349519003481 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 349519003482 FMN binding site [chemical binding]; other site 349519003483 active site 349519003484 catalytic residues [active] 349519003485 substrate binding site [chemical binding]; other site 349519003486 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 349519003487 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 349519003488 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 349519003489 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 349519003490 putative active site [active] 349519003491 catalytic site [active] 349519003492 putative metal binding site [ion binding]; other site 349519003493 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 349519003494 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 349519003495 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 349519003496 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 349519003497 dimer interface [polypeptide binding]; other site 349519003498 conserved gate region; other site 349519003499 putative PBP binding loops; other site 349519003500 ABC-ATPase subunit interface; other site 349519003501 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 349519003502 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 349519003503 putative PBP binding loops; other site 349519003504 ABC-ATPase subunit interface; other site 349519003505 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 349519003506 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 349519003507 Walker A/P-loop; other site 349519003508 ATP binding site [chemical binding]; other site 349519003509 Q-loop/lid; other site 349519003510 ABC transporter signature motif; other site 349519003511 Walker B; other site 349519003512 D-loop; other site 349519003513 H-loop/switch region; other site 349519003514 Phosphoglycerate Dehydrogenase, 2-hydroxyacid dehydrogenase family; Region: PGDH_1; cd12155 349519003515 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 349519003516 putative ligand binding site [chemical binding]; other site 349519003517 NAD binding site [chemical binding]; other site 349519003518 catalytic site [active] 349519003519 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 349519003520 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 349519003521 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 349519003522 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 349519003523 homodimer interface [polypeptide binding]; other site 349519003524 substrate-cofactor binding pocket; other site 349519003525 catalytic residue [active] 349519003526 Protein of unknown function (DUF1027); Region: DUF1027; pfam06265 349519003527 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 349519003528 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 349519003529 active site 349519003530 metal binding site [ion binding]; metal-binding site 349519003531 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 349519003532 Aquifex aeolicus AQ1575 and related proteins, metallophosphatase domain; Region: MPP_AQ1575; cd07390 349519003533 putative active site [active] 349519003534 putative metal binding site [ion binding]; other site 349519003535 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 349519003536 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 349519003537 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 349519003538 active site 349519003539 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 349519003540 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 349519003541 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 349519003542 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 349519003543 substrate binding site [chemical binding]; other site 349519003544 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 349519003545 HTH-like domain; Region: HTH_21; pfam13276 349519003546 Integrase core domain; Region: rve; pfam00665 349519003547 Integrase core domain; Region: rve_2; pfam13333 349519003548 Transposase; Region: HTH_Tnp_1; cl17663 349519003549 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 349519003550 Phage tail protein; Region: Sipho_tail; cl17486 349519003551 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 349519003552 CHAP domain; Region: CHAP; pfam05257 349519003553 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 349519003554 N-acetyl-D-glucosamine binding site [chemical binding]; other site 349519003555 catalytic residue [active] 349519003556 Protein of unknown function (DUF1268); Region: DUF1268; pfam06896 349519003557 Phage major tail protein; Region: Phage_tail; pfam04630 349519003558 Protein of unknown function (DUF806); Region: DUF806; pfam05657 349519003559 Bacteriophage protein of unknown function (DUF646); Region: DUF646; pfam04883 349519003560 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 349519003561 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 349519003562 oligomerization interface [polypeptide binding]; other site 349519003563 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 349519003564 Phage capsid family; Region: Phage_capsid; pfam05065 349519003565 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 349519003566 oligomer interface [polypeptide binding]; other site 349519003567 Clp protease; Region: CLP_protease; pfam00574 349519003568 active site residues [active] 349519003569 Phage-related protein [Function unknown]; Region: COG4695; cl01923 349519003570 Phage portal protein; Region: Phage_portal; pfam04860 349519003571 Phage Terminase; Region: Terminase_1; pfam03354 349519003572 Phage terminase, small subunit; Region: Terminase_4; pfam05119 349519003573 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 349519003574 HTH-like domain; Region: HTH_21; pfam13276 349519003575 Integrase core domain; Region: rve; pfam00665 349519003576 Integrase core domain; Region: rve_2; pfam13333 349519003577 Transposase; Region: HTH_Tnp_1; cl17663 349519003578 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 349519003579 Protein of unknown function (DUF722); Region: DUF722; pfam05263 349519003580 Endodeoxyribonuclease RusA; Region: RusA; pfam05866 349519003581 Ion channel; Region: Ion_trans_2; pfam07885 349519003582 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E_like proteins; Region: GAT1_Peptidase_E_like; cd03129 349519003583 catalytic triad [active] 349519003584 active site nucleophile [active] 349519003585 acid-resistance membrane protein; Provisional; Region: PRK10209 349519003586 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 349519003587 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 349519003588 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 349519003589 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 349519003590 Walker A/P-loop; other site 349519003591 ATP binding site [chemical binding]; other site 349519003592 Q-loop/lid; other site 349519003593 ABC transporter signature motif; other site 349519003594 Walker B; other site 349519003595 D-loop; other site 349519003596 H-loop/switch region; other site 349519003597 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 349519003598 HIT family signature motif; other site 349519003599 catalytic residue [active] 349519003600 peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405 349519003601 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 349519003602 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 349519003603 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 349519003604 generic binding surface II; other site 349519003605 generic binding surface I; other site 349519003606 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 349519003607 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 349519003608 Walker A/P-loop; other site 349519003609 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 349519003610 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 349519003611 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 349519003612 active site 349519003613 metal binding site [ion binding]; metal-binding site 349519003614 DNA binding site [nucleotide binding] 349519003615 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 349519003616 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 349519003617 active site 349519003618 catalytic triad [active] 349519003619 oxyanion hole [active] 349519003620 Predicted permeases [General function prediction only]; Region: RarD; COG2962 349519003621 EamA-like transporter family; Region: EamA; cl17759 349519003622 Sugar efflux transporter for intercellular exchange; Region: MtN3_slv; pfam03083 349519003623 Uncharacterized conserved protein [Function unknown]; Region: COG4748 349519003624 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 349519003625 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 349519003626 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 349519003627 G1 box; other site 349519003628 putative GEF interaction site [polypeptide binding]; other site 349519003629 GTP/Mg2+ binding site [chemical binding]; other site 349519003630 Switch I region; other site 349519003631 G2 box; other site 349519003632 G3 box; other site 349519003633 Switch II region; other site 349519003634 G4 box; other site 349519003635 G5 box; other site 349519003636 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 349519003637 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 349519003638 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 349519003639 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 349519003640 active site 349519003641 Uncharacterized protein family (UPF0223); Region: UPF0223; cl11484 349519003642 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 349519003643 active site 349519003644 catalytic residues [active] 349519003645 metal binding site [ion binding]; metal-binding site 349519003646 chaperone protein DnaJ; Provisional; Region: PRK14299 349519003647 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 349519003648 HSP70 interaction site [polypeptide binding]; other site 349519003649 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 349519003650 substrate binding site [polypeptide binding]; other site 349519003651 dimer interface [polypeptide binding]; other site 349519003652 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 349519003653 chaperone protein DnaK; Region: prok_dnaK; TIGR02350 349519003654 nucleotide binding site [chemical binding]; other site 349519003655 NEF interaction site [polypeptide binding]; other site 349519003656 SBD interface [polypeptide binding]; other site 349519003657 GrpE; Region: GrpE; pfam01025 349519003658 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 349519003659 dimer interface [polypeptide binding]; other site 349519003660 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 349519003661 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 349519003662 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 349519003663 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 349519003664 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 349519003665 active site 349519003666 Riboflavin kinase; Region: Flavokinase; smart00904 349519003667 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK02484 349519003668 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 349519003669 RNA binding site [nucleotide binding]; other site 349519003670 active site 349519003671 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 349519003672 HPr interaction site; other site 349519003673 glycerol kinase (GK) interaction site [polypeptide binding]; other site 349519003674 active site 349519003675 phosphorylation site [posttranslational modification] 349519003676 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674 349519003677 aromatic amino acid aminotransferase; Validated; Region: PRK07309 349519003678 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 349519003679 pyridoxal 5'-phosphate binding site [chemical binding]; other site 349519003680 homodimer interface [polypeptide binding]; other site 349519003681 catalytic residue [active] 349519003682 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 349519003683 translation initiation factor IF-2; Region: IF-2; TIGR00487 349519003684 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 349519003685 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 349519003686 G1 box; other site 349519003687 putative GEF interaction site [polypeptide binding]; other site 349519003688 GTP/Mg2+ binding site [chemical binding]; other site 349519003689 Switch I region; other site 349519003690 G2 box; other site 349519003691 G3 box; other site 349519003692 Switch II region; other site 349519003693 G4 box; other site 349519003694 G5 box; other site 349519003695 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 349519003696 Translation-initiation factor 2; Region: IF-2; pfam11987 349519003697 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 349519003698 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 349519003699 putative RNA binding cleft [nucleotide binding]; other site 349519003700 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 349519003701 NusA N-terminal domain; Region: NusA_N; pfam08529 349519003702 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 349519003703 RNA binding site [nucleotide binding]; other site 349519003704 homodimer interface [polypeptide binding]; other site 349519003705 NusA-like KH domain; Region: KH_5; pfam13184 349519003706 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 349519003707 G-X-X-G motif; other site 349519003708 ribosome maturation protein RimP; Reviewed; Region: PRK00092 349519003709 Sm and related proteins; Region: Sm_like; cl00259 349519003710 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 349519003711 putative oligomer interface [polypeptide binding]; other site 349519003712 putative RNA binding site [nucleotide binding]; other site 349519003713 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 349519003714 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 349519003715 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 349519003716 DHH family; Region: DHH; pfam01368 349519003717 DHHA2 domain; Region: DHHA2; pfam02833 349519003718 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 349519003719 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 349519003720 CAP-like domain; other site 349519003721 active site 349519003722 primary dimer interface [polypeptide binding]; other site 349519003723 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 349519003724 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 349519003725 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 349519003726 ATP binding site [chemical binding]; other site 349519003727 Mg2+ binding site [ion binding]; other site 349519003728 G-X-G motif; other site 349519003729 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 349519003730 anchoring element; other site 349519003731 dimer interface [polypeptide binding]; other site 349519003732 ATP binding site [chemical binding]; other site 349519003733 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 349519003734 active site 349519003735 putative metal-binding site [ion binding]; other site 349519003736 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 349519003737 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 349519003738 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 349519003739 putative active site [active] 349519003740 dimerization interface [polypeptide binding]; other site 349519003741 putative tRNAtyr binding site [nucleotide binding]; other site 349519003742 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 349519003743 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 349519003744 Zn2+ binding site [ion binding]; other site 349519003745 Mg2+ binding site [ion binding]; other site 349519003746 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 349519003747 synthetase active site [active] 349519003748 NTP binding site [chemical binding]; other site 349519003749 metal binding site [ion binding]; metal-binding site 349519003750 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 349519003751 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 349519003752 drug efflux system protein MdtG; Provisional; Region: PRK09874 349519003753 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 349519003754 putative substrate translocation pore; other site 349519003755 Carbamoylphosphate synthase large subunit (split gene in MJ) [Amino acid transport and metabolism / Nucleotide transport and metabolism]; Region: CarB; COG0458 349519003756 ATP-grasp domain; Region: ATP-grasp_4; cl17255 349519003757 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 349519003758 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; smart01096 349519003759 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 349519003760 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12838 349519003761 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 349519003762 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 349519003763 catalytic site [active] 349519003764 subunit interface [polypeptide binding]; other site 349519003765 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 349519003766 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 349519003767 active site 349519003768 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 349519003769 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 349519003770 RNA binding surface [nucleotide binding]; other site 349519003771 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 349519003772 active site 349519003773 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 349519003774 RNA/DNA hybrid binding site [nucleotide binding]; other site 349519003775 active site 349519003776 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 349519003777 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 349519003778 nucleotide binding site [chemical binding]; other site 349519003779 Glycosyl hydrolases family 32 N-terminal domain; Region: Glyco_hydro_32N; pfam00251 349519003780 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 349519003781 substrate binding [chemical binding]; other site 349519003782 active site 349519003783 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 349519003784 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 349519003785 active site turn [active] 349519003786 phosphorylation site [posttranslational modification] 349519003787 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 349519003788 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 349519003789 HPr interaction site; other site 349519003790 glycerol kinase (GK) interaction site [polypeptide binding]; other site 349519003791 active site 349519003792 phosphorylation site [posttranslational modification] 349519003793 Transcriptional regulators [Transcription]; Region: PurR; COG1609 349519003794 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 349519003795 DNA binding site [nucleotide binding] 349519003796 domain linker motif; other site 349519003797 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 349519003798 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 349519003799 active site 1 [active] 349519003800 dimer interface [polypeptide binding]; other site 349519003801 hexamer interface [polypeptide binding]; other site 349519003802 active site 2 [active] 349519003803 Uncharacterized conserved protein [Function unknown]; Region: COG1284 349519003804 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 349519003805 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 349519003806 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 349519003807 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 349519003808 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 349519003809 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 349519003810 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 349519003811 DNA binding residues [nucleotide binding] 349519003812 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 349519003813 putative dimer interface [polypeptide binding]; other site 349519003814 DNA polymerase I; Provisional; Region: PRK05755 349519003815 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 349519003816 active site 349519003817 metal binding site 1 [ion binding]; metal-binding site 349519003818 putative 5' ssDNA interaction site; other site 349519003819 metal binding site 3; metal-binding site 349519003820 metal binding site 2 [ion binding]; metal-binding site 349519003821 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 349519003822 putative DNA binding site [nucleotide binding]; other site 349519003823 putative metal binding site [ion binding]; other site 349519003824 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 349519003825 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 349519003826 active site 349519003827 DNA binding site [nucleotide binding] 349519003828 catalytic site [active] 349519003829 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 349519003830 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 349519003831 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 349519003832 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 349519003833 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 349519003834 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 349519003835 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 349519003836 putative tRNA-binding site [nucleotide binding]; other site 349519003837 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 349519003838 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 349519003839 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 349519003840 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 349519003841 dimer interface [polypeptide binding]; other site 349519003842 ADP-ribose binding site [chemical binding]; other site 349519003843 active site 349519003844 nudix motif; other site 349519003845 metal binding site [ion binding]; metal-binding site 349519003846 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 349519003847 DNA-binding site [nucleotide binding]; DNA binding site 349519003848 RNA-binding motif; other site 349519003849 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 349519003850 Sulfate transporter family; Region: Sulfate_transp; pfam00916 349519003851 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 349519003852 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_b; cd04185 349519003853 Probable Catalytic site; other site 349519003854 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 349519003855 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 349519003856 active site 349519003857 nucleotide binding site [chemical binding]; other site 349519003858 HIGH motif; other site 349519003859 KMSKS motif; other site 349519003860 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 349519003861 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 349519003862 Ligand binding site; other site 349519003863 Putative Catalytic site; other site 349519003864 DXD motif; other site 349519003865 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 349519003866 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 349519003867 UDP-galactopyranose mutase; Region: GLF; pfam03275 349519003868 Domain of unknown function (DUF4422); Region: DUF4422; pfam14393 349519003869 Bacterial sugar transferase; Region: Bac_transf; pfam02397 349519003870 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 349519003871 active site 349519003872 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 349519003873 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 349519003874 nucleotide binding site [chemical binding]; other site 349519003875 Bacterial protein of unknown function (DUF910); Region: DUF910; pfam06014 349519003876 Rhomboid family; Region: Rhomboid; pfam01694 349519003877 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 349519003878 Part of AAA domain; Region: AAA_19; pfam13245 349519003879 Family description; Region: UvrD_C_2; pfam13538 349519003880 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 349519003881 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 349519003882 hypothetical protein; Provisional; Region: PRK13662 349519003883 Fanconi anemia ID complex proteins FANCI and FANCD2; Region: FANC; cl17018 349519003884 RecX family; Region: RecX; cl00936 349519003885 dihydrodipicolinate reductase; Provisional; Region: PRK00048 349519003886 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 349519003887 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 349519003888 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 349519003889 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 349519003890 dimer interface [polypeptide binding]; other site 349519003891 active site 349519003892 catalytic residue [active] 349519003893 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 349519003894 M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670 349519003895 metal binding site [ion binding]; metal-binding site 349519003896 putative dimer interface [polypeptide binding]; other site 349519003897 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 349519003898 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 349519003899 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 349519003900 putative trimer interface [polypeptide binding]; other site 349519003901 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 349519003902 putative CoA binding site [chemical binding]; other site 349519003903 putative trimer interface [polypeptide binding]; other site 349519003904 putative CoA binding site [chemical binding]; other site 349519003905 diaminopimelate decarboxylase; Region: lysA; TIGR01048 349519003906 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 349519003907 active site 349519003908 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 349519003909 substrate binding site [chemical binding]; other site 349519003910 catalytic residues [active] 349519003911 dimer interface [polypeptide binding]; other site 349519003912 putative nicotinate phosphoribosyltransferase; Provisional; Region: PRK09198 349519003913 Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an important role in NAD production by either allowing quinolinic acid (QA) , quinolinate phosphoribosyl transferase (QAPRTase), or nicotinic acid (NA), nicotinate...; Region: PRTase_typeII; cl17275 349519003914 active site 349519003915 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 349519003916 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 349519003917 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014 349519003918 Nicotinamide mononucleotide transporter; Region: NMN_transporter; cl01256 349519003919 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 349519003920 CutC family; Region: CutC; cl01218 349519003921 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 349519003922 Domain of unknown function (DUF814); Region: DUF814; pfam05670 349519003923 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 349519003924 putative transporter; Provisional; Region: PRK10504 349519003925 putative substrate translocation pore; other site 349519003926 ornithine carbamoyltransferase; Validated; Region: PRK02102 349519003927 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 349519003928 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 349519003929 argininosuccinate lyase; Provisional; Region: PRK00855 349519003930 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 349519003931 active sites [active] 349519003932 tetramer interface [polypeptide binding]; other site 349519003933 argininosuccinate synthase; Provisional; Region: PRK13820 349519003934 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 349519003935 ANP binding site [chemical binding]; other site 349519003936 Substrate Binding Site II [chemical binding]; other site 349519003937 Substrate Binding Site I [chemical binding]; other site 349519003938 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 349519003939 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 349519003940 MgtE intracellular N domain; Region: MgtE_N; pfam03448 349519003941 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 349519003942 Divalent cation transporter; Region: MgtE; pfam01769 349519003943 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 349519003944 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 349519003945 active site 349519003946 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 349519003947 ATP-NAD kinase; Region: NAD_kinase; pfam01513 349519003948 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 349519003949 synthetase active site [active] 349519003950 NTP binding site [chemical binding]; other site 349519003951 metal binding site [ion binding]; metal-binding site 349519003952 Thioredoxin; Region: Thioredoxin_5; pfam13743 349519003953 Predicted RNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG2263 349519003954 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 349519003955 active site 349519003956 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 349519003957 DHH family; Region: DHH; pfam01368 349519003958 DHHA1 domain; Region: DHHA1; pfam02272 349519003959 Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; cl11538 349519003960 ribonuclease Z; Region: RNase_Z; TIGR02651 349519003961 methionine sulfoxide reductase A; Provisional; Region: PRK14054 349519003962 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 349519003963 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 349519003964 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 349519003965 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 349519003966 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 349519003967 intersubunit interface [polypeptide binding]; other site 349519003968 active site 349519003969 Zn2+ binding site [ion binding]; other site 349519003970 L-ribulokinase-like proteins; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-RBK_like; cd07778 349519003971 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 349519003972 putative N- and C-terminal domain interface [polypeptide binding]; other site 349519003973 putative active site [active] 349519003974 MgATP binding site [chemical binding]; other site 349519003975 catalytic site [active] 349519003976 metal binding site [ion binding]; metal-binding site 349519003977 putative carbohydrate binding site [chemical binding]; other site 349519003978 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 349519003979 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 349519003980 putative substrate translocation pore; other site 349519003981 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 349519003982 L-arabinose isomerase; Provisional; Region: PRK02929 349519003983 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 349519003984 hexamer (dimer of trimers) interface [polypeptide binding]; other site 349519003985 trimer interface [polypeptide binding]; other site 349519003986 substrate binding site [chemical binding]; other site 349519003987 Mn binding site [ion binding]; other site 349519003988 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 349519003989 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 349519003990 DNA-binding site [nucleotide binding]; DNA binding site 349519003991 Transcriptional regulators [Transcription]; Region: PurR; COG1609 349519003992 Ligand-binding domain of DNA transcription repressor specific for arabinose (AraR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AraR; cd01541 349519003993 putative dimerization interface [polypeptide binding]; other site 349519003994 putative ligand binding site [chemical binding]; other site 349519003995 Uncharacterized conserved protein [Function unknown]; Region: COG2966 349519003996 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 349519003997 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 349519003998 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 349519003999 DNA photolyase; Region: DNA_photolyase; pfam00875 349519004000 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 349519004001 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 349519004002 myosin-cross-reactive antigen; Provisional; Region: PRK13977 349519004003 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 349519004004 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 349519004005 NADP binding site [chemical binding]; other site 349519004006 active site 349519004007 putative substrate binding site [chemical binding]; other site 349519004008 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 349519004009 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 349519004010 NAD binding site [chemical binding]; other site 349519004011 substrate binding site [chemical binding]; other site 349519004012 homodimer interface [polypeptide binding]; other site 349519004013 active site 349519004014 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 349519004015 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 349519004016 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 349519004017 substrate binding site; other site 349519004018 tetramer interface; other site 349519004019 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 349519004020 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 349519004021 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 349519004022 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 349519004023 active site 349519004024 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 349519004025 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 349519004026 active site 349519004027 Capsular polysaccharide synthesis protein; Region: Caps_synth; pfam05704 349519004028 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 349519004029 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 349519004030 active site 349519004031 nucleotide binding site [chemical binding]; other site 349519004032 HIGH motif; other site 349519004033 KMSKS motif; other site 349519004034 LicD family; Region: LicD; pfam04991 349519004035 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_6; cd04955 349519004036 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 349519004037 Bacterial sugar transferase; Region: Bac_transf; pfam02397 349519004038 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 349519004039 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 349519004040 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 349519004041 Nucleotide binding site [chemical binding]; other site 349519004042 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 349519004043 Chain length determinant protein; Region: Wzz; cl15801 349519004044 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 349519004045 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 349519004046 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 349519004047 RimM N-terminal domain; Region: RimM; pfam01782 349519004048 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 349519004049 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 349519004050 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 349519004051 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 349519004052 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 349519004053 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 349519004054 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 349519004055 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 349519004056 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 349519004057 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 349519004058 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 349519004059 Glycosyl hydrolase family 70; Region: Glyco_hydro_70; pfam02324 349519004060 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 349519004061 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 349519004062 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 349519004063 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 349519004064 Glycosyl hydrolase family 70; Region: Glyco_hydro_70; pfam02324 349519004065 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 349519004066 active site 349519004067 catalytic site [active] 349519004068 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 349519004069 Predicted transcriptional regulator 349519004070 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 349519004071 HTH-like domain; Region: HTH_21; pfam13276 349519004072 Integrase core domain; Region: rve; pfam00665 349519004073 Integrase core domain; Region: rve_2; pfam13333 349519004074 Transposase; Region: HTH_Tnp_1; cl17663 349519004075 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 349519004076 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 349519004077 DNA binding site [nucleotide binding] 349519004078 active site 349519004079 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 349519004080 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 349519004081 active site 349519004082 phosphorylation site [posttranslational modification] 349519004083 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 349519004084 active site 349519004085 P-loop; other site 349519004086 phosphorylation site [posttranslational modification] 349519004087 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 349519004088 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 349519004089 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 349519004090 putative substrate binding site [chemical binding]; other site 349519004091 putative ATP binding site [chemical binding]; other site 349519004092 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 349519004093 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 349519004094 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 349519004095 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C); Region: NT5C; cl17836 349519004096 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 349519004097 Bacterial PH domain; Region: DUF304; pfam03703 349519004098 Bacterial PH domain; Region: DUF304; pfam03703 349519004099 Bacterial PH domain; Region: DUF304; pfam03703 349519004100 Bacterial PH domain; Region: DUF304; cl01348 349519004101 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 349519004102 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 349519004103 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 349519004104 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 349519004105 Substrate-binding site [chemical binding]; other site 349519004106 Substrate specificity [chemical binding]; other site 349519004107 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 349519004108 RuvA N terminal domain; Region: RuvA_N; pfam01330 349519004109 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 349519004110 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 349519004111 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 349519004112 Aquifex aeolicus AQ1575 and related proteins, metallophosphatase domain; Region: MPP_AQ1575; cd07390 349519004113 putative active site [active] 349519004114 putative metal binding site [ion binding]; other site 349519004115 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 349519004116 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 349519004117 Walker A motif; other site 349519004118 ATP binding site [chemical binding]; other site 349519004119 Walker B motif; other site 349519004120 arginine finger; other site 349519004121 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 349519004122 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 349519004123 active site 349519004124 metal binding site [ion binding]; metal-binding site 349519004125 homotetramer interface [polypeptide binding]; other site 349519004126 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 349519004127 active site 349519004128 dimerization interface [polypeptide binding]; other site 349519004129 glutamate racemase; Provisional; Region: PRK00865 349519004130 Protein of unknown function (DUF2507); Region: DUF2507; pfam10702 349519004131 D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092 349519004132 DltD N-terminal region; Region: DltD_N; pfam04915 349519004133 DltD central region; Region: DltD_M; pfam04918 349519004134 DltD C-terminal region; Region: DltD_C; pfam04914 349519004135 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 349519004136 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 349519004137 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 349519004138 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 349519004139 acyl-activating enzyme (AAE) consensus motif; other site 349519004140 AMP binding site [chemical binding]; other site 349519004141 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 349519004142 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 349519004143 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 349519004144 DEAD-like helicases superfamily; Region: DEXDc; smart00487 349519004145 ATP binding site [chemical binding]; other site 349519004146 Mg++ binding site [ion binding]; other site 349519004147 motif III; other site 349519004148 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 349519004149 nucleotide binding region [chemical binding]; other site 349519004150 ATP-binding site [chemical binding]; other site 349519004151 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 349519004152 DHH family; Region: DHH; pfam01368 349519004153 DHHA1 domain; Region: DHHA1; pfam02272 349519004154 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 349519004155 active site 349519004156 DNA polymerase IV; Validated; Region: PRK02406 349519004157 DNA binding site [nucleotide binding] 349519004158 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 349519004159 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 349519004160 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 349519004161 active site 349519004162 substrate binding site [chemical binding]; other site 349519004163 metal binding site [ion binding]; metal-binding site 349519004164 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 349519004165 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 349519004166 Alpha amylase catalytic domain found in sucrose phosphorylase (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase; cd11355 349519004167 sucrose phosphorylase; Region: sucrose_gtfA; TIGR03852 349519004168 active site 349519004169 homodimer interface [polypeptide binding]; other site 349519004170 catalytic site [active] 349519004171 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 349519004172 Major Facilitator Superfamily; Region: MFS_1; pfam07690 349519004173 putative substrate translocation pore; other site 349519004174 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 349519004175 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 349519004176 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 349519004177 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 349519004178 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 349519004179 active site 349519004180 tetramer interface; other site 349519004181 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 349519004182 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 349519004183 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 349519004184 HPr kinase/phosphorylase; Provisional; Region: PRK05428 349519004185 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 349519004186 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 349519004187 Hpr binding site; other site 349519004188 active site 349519004189 homohexamer subunit interaction site [polypeptide binding]; other site 349519004190 Membrane protein of unknown function; Region: DUF360; pfam04020 349519004191 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 349519004192 PhoU domain; Region: PhoU; pfam01895 349519004193 PhoU domain; Region: PhoU; pfam01895 349519004194 phosphate transporter ATP-binding protein; Provisional; Region: PRK14239 349519004195 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 349519004196 Walker A/P-loop; other site 349519004197 ATP binding site [chemical binding]; other site 349519004198 Q-loop/lid; other site 349519004199 ABC transporter signature motif; other site 349519004200 Walker B; other site 349519004201 D-loop; other site 349519004202 H-loop/switch region; other site 349519004203 phosphate transporter ATP-binding protein; Provisional; Region: PRK14237 349519004204 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 349519004205 Walker A/P-loop; other site 349519004206 ATP binding site [chemical binding]; other site 349519004207 Q-loop/lid; other site 349519004208 ABC transporter signature motif; other site 349519004209 Walker B; other site 349519004210 D-loop; other site 349519004211 H-loop/switch region; other site 349519004212 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 349519004213 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 349519004214 dimer interface [polypeptide binding]; other site 349519004215 conserved gate region; other site 349519004216 putative PBP binding loops; other site 349519004217 ABC-ATPase subunit interface; other site 349519004218 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 349519004219 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 349519004220 dimer interface [polypeptide binding]; other site 349519004221 conserved gate region; other site 349519004222 putative PBP binding loops; other site 349519004223 ABC-ATPase subunit interface; other site 349519004224 PBP superfamily domain; Region: PBP_like_2; cl17296 349519004225 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 349519004226 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 349519004227 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 349519004228 dimer interface [polypeptide binding]; other site 349519004229 phosphorylation site [posttranslational modification] 349519004230 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 349519004231 ATP binding site [chemical binding]; other site 349519004232 Mg2+ binding site [ion binding]; other site 349519004233 G-X-G motif; other site 349519004234 PBP superfamily domain; Region: PBP_like_2; cl17296 349519004235 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 349519004236 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 349519004237 active site 349519004238 phosphorylation site [posttranslational modification] 349519004239 intermolecular recognition site; other site 349519004240 dimerization interface [polypeptide binding]; other site 349519004241 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 349519004242 DNA binding site [nucleotide binding] 349519004243 recombinase A; Provisional; Region: recA; PRK09354 349519004244 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 349519004245 hexamer interface [polypeptide binding]; other site 349519004246 Walker A motif; other site 349519004247 ATP binding site [chemical binding]; other site 349519004248 Walker B motif; other site 349519004249 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 349519004250 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 349519004251 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 349519004252 non-specific DNA binding site [nucleotide binding]; other site 349519004253 salt bridge; other site 349519004254 sequence-specific DNA binding site [nucleotide binding]; other site 349519004255 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 349519004256 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 349519004257 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 349519004258 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 349519004259 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 349519004260 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 349519004261 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 349519004262 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 349519004263 putative active site [active] 349519004264 catalytic site [active] 349519004265 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 349519004266 putative active site [active] 349519004267 catalytic site [active] 349519004268 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 349519004269 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 349519004270 substrate binding pocket [chemical binding]; other site 349519004271 membrane-bound complex binding site; other site 349519004272 hinge residues; other site 349519004273 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 349519004274 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 349519004275 Walker A/P-loop; other site 349519004276 ATP binding site [chemical binding]; other site 349519004277 Q-loop/lid; other site 349519004278 ABC transporter signature motif; other site 349519004279 Walker B; other site 349519004280 D-loop; other site 349519004281 H-loop/switch region; other site 349519004282 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 349519004283 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 349519004284 dimer interface [polypeptide binding]; other site 349519004285 conserved gate region; other site 349519004286 putative PBP binding loops; other site 349519004287 ABC-ATPase subunit interface; other site 349519004288 rod shape-determining protein MreD; Region: shape_MreD; TIGR03426 349519004289 rod shape-determining protein MreC; Provisional; Region: PRK13922 349519004290 rod shape-determining protein MreC; Region: MreC; pfam04085 349519004291 rod shape-determining protein MreB; Provisional; Region: PRK13927 349519004292 MreB and similar proteins; Region: MreB_like; cd10225 349519004293 nucleotide binding site [chemical binding]; other site 349519004294 Mg binding site [ion binding]; other site 349519004295 putative protofilament interaction site [polypeptide binding]; other site 349519004296 RodZ interaction site [polypeptide binding]; other site 349519004297 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 349519004298 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 349519004299 Walker A motif; other site 349519004300 ATP binding site [chemical binding]; other site 349519004301 Walker B motif; other site 349519004302 arginine finger; other site 349519004303 UvrB/uvrC motif; Region: UVR; pfam02151 349519004304 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 349519004305 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 349519004306 Walker A motif; other site 349519004307 ATP binding site [chemical binding]; other site 349519004308 Walker B motif; other site 349519004309 arginine finger; other site 349519004310 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 349519004311 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 349519004312 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 349519004313 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 349519004314 GDP-binding site [chemical binding]; other site 349519004315 ACT binding site; other site 349519004316 IMP binding site; other site 349519004317 conserved hypothetical integral membrane protein; Region: TIGR03766 349519004318 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 349519004319 putative glycosyltransferase, exosortase G-associated; Region: glyc2_xrt_Gpos1; TIGR03111 349519004320 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 349519004321 DXD motif; other site 349519004322 Predicted membrane protein [Function unknown]; Region: COG4083; cl15694 349519004323 Firmicu-CTERM domain; Region: Firmicu_CTERM; TIGR04145 349519004324 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 349519004325 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 349519004326 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 349519004327 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 349519004328 Glycosyl hydrolase family 70; Region: Glyco_hydro_70; pfam02324 349519004329 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 349519004330 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 349519004331 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 349519004332 SH3-like domain; Region: SH3_8; pfam13457 349519004333 SH3-like domain; Region: SH3_8; pfam13457 349519004334 SH3-like domain; Region: SH3_8; pfam13457 349519004335 SH3-like domain; Region: SH3_8; pfam13457 349519004336 SH3-like domain; Region: SH3_8; pfam13457 349519004337 SH3-like domain; Region: SH3_8; pfam13457 349519004338 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 349519004339 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 349519004340 pyridoxal 5'-phosphate binding site [chemical binding]; other site 349519004341 homodimer interface [polypeptide binding]; other site 349519004342 catalytic residue [active] 349519004343 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 349519004344 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 349519004345 active site 349519004346 motif I; other site 349519004347 motif II; other site 349519004348 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 349519004349 signal recognition particle protein; Provisional; Region: PRK10867 349519004350 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 349519004351 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 349519004352 P loop; other site 349519004353 GTP binding site [chemical binding]; other site 349519004354 Signal peptide binding domain; Region: SRP_SPB; pfam02978 349519004355 putative DNA-binding protein; Validated; Region: PRK00118 349519004356 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 349519004357 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 349519004358 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 349519004359 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 349519004360 P loop; other site 349519004361 GTP binding site [chemical binding]; other site 349519004362 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 349519004363 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 349519004364 Walker A/P-loop; other site 349519004365 ATP binding site [chemical binding]; other site 349519004366 Q-loop/lid; other site 349519004367 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 349519004368 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 349519004369 ABC transporter signature motif; other site 349519004370 Walker B; other site 349519004371 D-loop; other site 349519004372 H-loop/switch region; other site 349519004373 ribonuclease III; Reviewed; Region: rnc; PRK00102 349519004374 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 349519004375 dimerization interface [polypeptide binding]; other site 349519004376 active site 349519004377 metal binding site [ion binding]; metal-binding site 349519004378 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 349519004379 dsRNA binding site [nucleotide binding]; other site 349519004380 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 349519004381 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 349519004382 active site 349519004383 substrate binding site [chemical binding]; other site 349519004384 metal binding site [ion binding]; metal-binding site 349519004385 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 349519004386 YbbR-like protein; Region: YbbR; pfam07949 349519004387 Uncharacterized conserved protein [Function unknown]; Region: COG1624 349519004388 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 349519004389 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 349519004390 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 349519004391 FAD binding domain; Region: FAD_binding_4; pfam01565 349519004392 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 349519004393 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 349519004394 active site 349519004395 multimer interface [polypeptide binding]; other site 349519004396 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 349519004397 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 349519004398 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 349519004399 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 349519004400 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 349519004401 ATP binding site [chemical binding]; other site 349519004402 Mg2+ binding site [ion binding]; other site 349519004403 G-X-G motif; other site 349519004404 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 349519004405 ATP binding site [chemical binding]; other site 349519004406 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 349519004407 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 349519004408 MutS domain I; Region: MutS_I; pfam01624 349519004409 MutS domain II; Region: MutS_II; pfam05188 349519004410 MutS domain III; Region: MutS_III; pfam05192 349519004411 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 349519004412 Walker A/P-loop; other site 349519004413 ATP binding site [chemical binding]; other site 349519004414 Q-loop/lid; other site 349519004415 ABC transporter signature motif; other site 349519004416 Walker B; other site 349519004417 D-loop; other site 349519004418 H-loop/switch region; other site 349519004419 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 349519004420 Y-family of DNA polymerases; Region: PolY; cl12025 349519004421 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 349519004422 generic binding surface II; other site 349519004423 ssDNA binding site; other site 349519004424 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 349519004425 ATP binding site [chemical binding]; other site 349519004426 putative Mg++ binding site [ion binding]; other site 349519004427 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 349519004428 nucleotide binding region [chemical binding]; other site 349519004429 ATP-binding site [chemical binding]; other site 349519004430 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 349519004431 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 349519004432 NAD(P) binding site [chemical binding]; other site 349519004433 catalytic residues [active] 349519004434 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 349519004435 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 349519004436 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 349519004437 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 349519004438 non-specific DNA binding site [nucleotide binding]; other site 349519004439 salt bridge; other site 349519004440 sequence-specific DNA binding site [nucleotide binding]; other site 349519004441 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; cl17818 349519004442 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 349519004443 non-specific DNA binding site [nucleotide binding]; other site 349519004444 salt bridge; other site 349519004445 sequence-specific DNA binding site [nucleotide binding]; other site 349519004446 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 349519004447 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 349519004448 Walker A/P-loop; other site 349519004449 ATP binding site [chemical binding]; other site 349519004450 Q-loop/lid; other site 349519004451 ABC transporter signature motif; other site 349519004452 Walker B; other site 349519004453 D-loop; other site 349519004454 H-loop/switch region; other site 349519004455 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 349519004456 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 349519004457 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 349519004458 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 349519004459 dimer interface [polypeptide binding]; other site 349519004460 conserved gate region; other site 349519004461 putative PBP binding loops; other site 349519004462 ABC-ATPase subunit interface; other site 349519004463 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 349519004464 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 349519004465 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 349519004466 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 349519004467 Walker A/P-loop; other site 349519004468 ATP binding site [chemical binding]; other site 349519004469 Q-loop/lid; other site 349519004470 ABC transporter signature motif; other site 349519004471 Walker B; other site 349519004472 D-loop; other site 349519004473 H-loop/switch region; other site 349519004474 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 349519004475 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 349519004476 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 349519004477 DNA-binding site [nucleotide binding]; DNA binding site 349519004478 TrkA-C domain; Region: TrkA_C; pfam02080 349519004479 BioY family; Region: BioY; pfam02632 349519004480 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 349519004481 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190 349519004482 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 349519004483 homodimer interface [polypeptide binding]; other site 349519004484 NADP binding site [chemical binding]; other site 349519004485 substrate binding site [chemical binding]; other site 349519004486 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 349519004487 catalytic motif [active] 349519004488 Zn binding site [ion binding]; other site 349519004489 thymidylate synthase; Region: thym_sym; TIGR03284 349519004490 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 349519004491 dimerization interface [polypeptide binding]; other site 349519004492 active site 349519004493 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 349519004494 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 349519004495 Coenzyme A binding pocket [chemical binding]; other site 349519004496 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 349519004497 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_b; cd04185 349519004498 Probable Catalytic site; other site 349519004499 putative glycosyl transferase; Provisional; Region: PRK10073 349519004500 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 349519004501 active site 349519004502 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 349519004503 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 349519004504 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 349519004505 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 349519004506 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 349519004507 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 349519004508 Walker A/P-loop; other site 349519004509 ATP binding site [chemical binding]; other site 349519004510 Q-loop/lid; other site 349519004511 ABC transporter signature motif; other site 349519004512 Walker B; other site 349519004513 D-loop; other site 349519004514 H-loop/switch region; other site 349519004515 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 349519004516 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 349519004517 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 349519004518 Class III ribonucleotide reductase; Region: RNR_III; cd01675 349519004519 effector binding site; other site 349519004520 active site 349519004521 Zn binding site [ion binding]; other site 349519004522 glycine loop; other site 349519004523 acetolactate synthase; Reviewed; Region: PRK08617 349519004524 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 349519004525 PYR/PP interface [polypeptide binding]; other site 349519004526 dimer interface [polypeptide binding]; other site 349519004527 TPP binding site [chemical binding]; other site 349519004528 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 349519004529 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 349519004530 TPP-binding site [chemical binding]; other site 349519004531 GTPase CgtA; Reviewed; Region: obgE; PRK12297 349519004532 GTP1/OBG; Region: GTP1_OBG; pfam01018 349519004533 Obg GTPase; Region: Obg; cd01898 349519004534 G1 box; other site 349519004535 GTP/Mg2+ binding site [chemical binding]; other site 349519004536 Switch I region; other site 349519004537 G2 box; other site 349519004538 G3 box; other site 349519004539 Switch II region; other site 349519004540 G4 box; other site 349519004541 G5 box; other site 349519004542 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 349519004543 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 349519004544 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 349519004545 active site 349519004546 catalytic site [active] 349519004547 putative DNA binding site [nucleotide binding]; other site 349519004548 GIY-YIG motif/motif A; other site 349519004549 metal binding site [ion binding]; metal-binding site 349519004550 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 349519004551 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 349519004552 DNA binding site [nucleotide binding] 349519004553 CTP synthetase; Validated; Region: pyrG; PRK05380 349519004554 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 349519004555 Catalytic site [active] 349519004556 active site 349519004557 UTP binding site [chemical binding]; other site 349519004558 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 349519004559 active site 349519004560 putative oxyanion hole; other site 349519004561 catalytic triad [active] 349519004562 Predicted RNA-binding protein, contains TRAM domain [General function prediction only]; Region: COG3269 349519004563 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 349519004564 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 349519004565 S-adenosylmethionine binding site [chemical binding]; other site 349519004566 putative lipid kinase; Reviewed; Region: PRK13055 349519004567 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 349519004568 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 349519004569 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 349519004570 GatB domain; Region: GatB_Yqey; smart00845 349519004571 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 349519004572 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 349519004573 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 349519004574 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 349519004575 16S/18S rRNA binding site [nucleotide binding]; other site 349519004576 S13e-L30e interaction site [polypeptide binding]; other site 349519004577 25S rRNA binding site [nucleotide binding]; other site 349519004578 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 349519004579 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 349519004580 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 349519004581 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 349519004582 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 349519004583 Competence protein; Region: Competence; pfam03772 349519004584 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 349519004585 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 349519004586 SLBB domain; Region: SLBB; pfam10531 349519004587 comEA protein; Region: comE; TIGR01259 349519004588 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 349519004589 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 349519004590 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 349519004591 Cl- selectivity filter; other site 349519004592 Cl- binding residues [ion binding]; other site 349519004593 pore gating glutamate residue; other site 349519004594 dimer interface [polypeptide binding]; other site 349519004595 H+/Cl- coupling transport residue; other site 349519004596 TrkA-C domain; Region: TrkA_C; pfam02080 349519004597 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 349519004598 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 349519004599 Substrate binding site; other site 349519004600 Mg++ binding site; other site 349519004601 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 349519004602 active site 349519004603 substrate binding site [chemical binding]; other site 349519004604 CoA binding site [chemical binding]; other site 349519004605 pur operon repressor; Provisional; Region: PRK09213 349519004606 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 349519004607 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 349519004608 active site 349519004609 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 349519004610 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 349519004611 ABC-ATPase subunit interface; other site 349519004612 dimer interface [polypeptide binding]; other site 349519004613 putative PBP binding regions; other site 349519004614 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 349519004615 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 349519004616 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 349519004617 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 349519004618 intersubunit interface [polypeptide binding]; other site 349519004619 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 349519004620 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 349519004621 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 349519004622 S-adenosylmethionine binding site [chemical binding]; other site 349519004623 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 349519004624 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 349519004625 putative active site [active] 349519004626 putative metal binding site [ion binding]; other site 349519004627 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 349519004628 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 349519004629 active site 349519004630 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 349519004631 putative RNA binding site [nucleotide binding]; other site 349519004632 Asp23 family; Region: Asp23; pfam03780 349519004633 elongation factor P; Validated; Region: PRK00529 349519004634 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 349519004635 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 349519004636 RNA binding site [nucleotide binding]; other site 349519004637 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 349519004638 RNA binding site [nucleotide binding]; other site 349519004639 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 349519004640 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 349519004641 Protein of unknown function (DUF1447); Region: DUF1447; pfam07288 349519004642 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 349519004643 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 349519004644 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 349519004645 phosphoenolpyruvate carboxylase; Provisional; Region: PRK13655 349519004646 phosphoenolpyruvate carboxylase, archaeal type; Region: PEPCase_arch; TIGR02751 349519004647 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 349519004648 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 349519004649 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 349519004650 S-adenosylmethionine synthetase; Validated; Region: PRK05250 349519004651 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 349519004652 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 349519004653 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 349519004654 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493 349519004655 Protein of unknown function (DUF1054); Region: DUF1054; pfam06335 349519004656 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 349519004657 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 349519004658 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 349519004659 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 349519004660 metal binding site 2 [ion binding]; metal-binding site 349519004661 putative DNA binding helix; other site 349519004662 metal binding site 1 [ion binding]; metal-binding site 349519004663 dimer interface [polypeptide binding]; other site 349519004664 structural Zn2+ binding site [ion binding]; other site 349519004665 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 349519004666 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 349519004667 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 349519004668 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 349519004669 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 349519004670 motif II; other site 349519004671 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 349519004672 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 349519004673 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 349519004674 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 349519004675 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 349519004676 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 349519004677 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 349519004678 hypothetical protein; Provisional; Region: PRK06446 349519004679 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_4; cd05681 349519004680 metal binding site [ion binding]; metal-binding site 349519004681 dimer interface [polypeptide binding]; other site 349519004682 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 349519004683 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 349519004684 Walker A/P-loop; other site 349519004685 ATP binding site [chemical binding]; other site 349519004686 Q-loop/lid; other site 349519004687 ABC transporter signature motif; other site 349519004688 Walker B; other site 349519004689 D-loop; other site 349519004690 H-loop/switch region; other site 349519004691 NIL domain; Region: NIL; pfam09383 349519004692 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 349519004693 dimer interface [polypeptide binding]; other site 349519004694 conserved gate region; other site 349519004695 ABC-ATPase subunit interface; other site 349519004696 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 349519004697 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 349519004698 DNA-binding site [nucleotide binding]; DNA binding site 349519004699 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 349519004700 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 349519004701 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 349519004702 active site 349519004703 dimer interface [polypeptide binding]; other site 349519004704 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 349519004705 tetramer interfaces [polypeptide binding]; other site 349519004706 binuclear metal-binding site [ion binding]; other site 349519004707 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 349519004708 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 349519004709 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; cl01943 349519004710 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 349519004711 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 349519004712 Walker A/P-loop; other site 349519004713 ATP binding site [chemical binding]; other site 349519004714 Q-loop/lid; other site 349519004715 ABC transporter signature motif; other site 349519004716 Walker B; other site 349519004717 D-loop; other site 349519004718 H-loop/switch region; other site 349519004719 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 349519004720 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 349519004721 Walker A/P-loop; other site 349519004722 ATP binding site [chemical binding]; other site 349519004723 Q-loop/lid; other site 349519004724 ABC transporter signature motif; other site 349519004725 Walker B; other site 349519004726 D-loop; other site 349519004727 H-loop/switch region; other site 349519004728 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 349519004729 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 349519004730 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 349519004731 Glycosyl hydrolase family 70; Region: Glyco_hydro_70; pfam02324 349519004732 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 349519004733 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 349519004734 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 349519004735 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 349519004736 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 349519004737 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 349519004738 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 349519004739 putative substrate translocation pore; other site 349519004740 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 349519004741 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 349519004742 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 349519004743 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 349519004744 dimer interface [polypeptide binding]; other site 349519004745 active site 349519004746 metal binding site [ion binding]; metal-binding site 349519004747 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 349519004748 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 349519004749 NAD(P) binding site [chemical binding]; other site 349519004750 active site 349519004751 competence damage-inducible protein A; Provisional; Region: PRK00549 349519004752 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 349519004753 putative MPT binding site; other site 349519004754 Competence-damaged protein; Region: CinA; pfam02464 349519004755 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 349519004756 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 349519004757 Domain of unknown function DUF87; Region: DUF87; pfam01935 349519004758 AAA-like domain; Region: AAA_10; pfam12846 349519004759 Predicted transcriptional regulators [Transcription]; Region: COG1733 349519004760 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 349519004761 Topoisomerase IA [DNA replication, recombination, and repair]; Region: TopA; COG0550 349519004762 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 349519004763 active site 349519004764 metal binding site [ion binding]; metal-binding site 349519004765 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cl11986 349519004766 domain I; other site 349519004767 DNA binding groove [nucleotide binding] 349519004768 phosphate binding site [ion binding]; other site 349519004769 domain II; other site 349519004770 domain III; other site 349519004771 nucleotide binding site [chemical binding]; other site 349519004772 catalytic site [active] 349519004773 domain IV; other site 349519004774 Protein of unknown function (DUF3021); Region: DUF3021; pfam11457 349519004775 LytTr DNA-binding domain; Region: LytTR; smart00850 349519004776 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 349519004777 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 349519004778 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 349519004779 Walker A/P-loop; other site 349519004780 ATP binding site [chemical binding]; other site 349519004781 Q-loop/lid; other site 349519004782 ABC transporter signature motif; other site 349519004783 Walker B; other site 349519004784 D-loop; other site 349519004785 H-loop/switch region; other site 349519004786 beta-phosphoglucomutase; Region: bPGM; TIGR01990 349519004787 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 349519004788 motif II; other site 349519004789 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 349519004790 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 349519004791 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 349519004792 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 349519004793 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 349519004794 HPr interaction site; other site 349519004795 glycerol kinase (GK) interaction site [polypeptide binding]; other site 349519004796 active site 349519004797 phosphorylation site [posttranslational modification] 349519004798 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 349519004799 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 349519004800 active site turn [active] 349519004801 phosphorylation site [posttranslational modification] 349519004802 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 349519004803 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 349519004804 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 349519004805 DNA-binding site [nucleotide binding]; DNA binding site 349519004806 UTRA domain; Region: UTRA; pfam07702 349519004807 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4487 349519004808 Uncharacterized protein conserved in bacteria (DUF2130); Region: DUF2130; pfam09903 349519004809 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 349519004810 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 349519004811 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 349519004812 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 349519004813 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 349519004814 motif II; other site 349519004815 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 349519004816 putative fructoselysine transporter; Provisional; Region: frlA; PRK11357 349519004817 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 349519004818 putative substrate translocation pore; other site 349519004819 Major Facilitator Superfamily; Region: MFS_1; pfam07690 349519004820 Bacteriophage peptidoglycan hydrolase; Region: Amidase_5; pfam05382 349519004821 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 349519004822 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 349519004823 dimer interface [polypeptide binding]; other site 349519004824 putative anticodon binding site; other site 349519004825 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 349519004826 motif 1; other site 349519004827 active site 349519004828 motif 2; other site 349519004829 motif 3; other site 349519004830 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 349519004831 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 349519004832 dimerization interface [polypeptide binding]; other site 349519004833 domain crossover interface; other site 349519004834 redox-dependent activation switch; other site 349519004835 ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465 349519004836 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 349519004837 Walker A motif; other site 349519004838 ATP binding site [chemical binding]; other site 349519004839 Walker B motif; other site 349519004840 arginine finger; other site 349519004841 Peptidase family M41; Region: Peptidase_M41; pfam01434 349519004842 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 349519004843 active site 349519004844 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 349519004845 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 349519004846 Ligand Binding Site [chemical binding]; other site 349519004847 TilS substrate C-terminal domain; Region: TilS_C; smart00977 349519004848 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 349519004849 Septum formation initiator; Region: DivIC; pfam04977 349519004850 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 349519004851 RNA binding surface [nucleotide binding]; other site 349519004852 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 349519004853 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 349519004854 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 349519004855 ATP binding site [chemical binding]; other site 349519004856 putative Mg++ binding site [ion binding]; other site 349519004857 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 349519004858 nucleotide binding region [chemical binding]; other site 349519004859 ATP-binding site [chemical binding]; other site 349519004860 TRCF domain; Region: TRCF; pfam03461 349519004861 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 349519004862 putative active site [active] 349519004863 catalytic residue [active] 349519004864 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 349519004865 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 349519004866 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 349519004867 Ca binding site [ion binding]; other site 349519004868 active site 349519004869 catalytic site [active] 349519004870 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 349519004871 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 349519004872 putative substrate translocation pore; other site 349519004873 Transcriptional regulators [Transcription]; Region: PurR; COG1609 349519004874 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 349519004875 DNA binding site [nucleotide binding] 349519004876 domain linker motif; other site 349519004877 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 349519004878 1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; cl17224 349519004879 UbiA prenyltransferase family; Region: UbiA; pfam01040 349519004880 Predicted membrane protein [Function unknown]; Region: COG2323 349519004881 Protein of unknown function (DUF3290); Region: DUF3290; pfam11694 349519004882 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 349519004883 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 349519004884 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 349519004885 ring oligomerisation interface [polypeptide binding]; other site 349519004886 ATP/Mg binding site [chemical binding]; other site 349519004887 stacking interactions; other site 349519004888 hinge regions; other site 349519004889 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 349519004890 oligomerisation interface [polypeptide binding]; other site 349519004891 mobile loop; other site 349519004892 roof hairpin; other site 349519004893 Uncharacterized conserved protein [Function unknown]; Region: COG1284 349519004894 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 349519004895 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 349519004896 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 349519004897 Domain of unknown function (DUF956); Region: DUF956; pfam06115 349519004898 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 349519004899 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 349519004900 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 349519004901 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 349519004902 active pocket/dimerization site; other site 349519004903 active site 349519004904 phosphorylation site [posttranslational modification] 349519004905 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 349519004906 active site 349519004907 phosphorylation site [posttranslational modification] 349519004908 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 349519004909 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 349519004910 beta-1,6-galactofuranosyltransferase; Provisional; Region: PRK09814 349519004911 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 349519004912 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 349519004913 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 349519004914 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 349519004915 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 349519004916 choice-of-anchor A domain; Region: choice_anch_A; TIGR04215 349519004917 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 349519004918 sequence-specific DNA binding site [nucleotide binding]; other site 349519004919 salt bridge; other site 349519004920 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 349519004921 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 349519004922 non-specific DNA binding site [nucleotide binding]; other site 349519004923 salt bridge; other site 349519004924 sequence-specific DNA binding site [nucleotide binding]; other site 349519004925 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 349519004926 dimer interface [polypeptide binding]; other site 349519004927 FMN binding site [chemical binding]; other site 349519004928 NADPH bind site [chemical binding]; other site 349519004929 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 349519004930 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 349519004931 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 349519004932 active site 349519004933 motif I; other site 349519004934 motif II; other site 349519004935 Peptidoglycan interpeptide bridge formation enzyme [Cell wall/membrane/envelope biogenesis]; Region: COG2348 349519004936 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 349519004937 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 349519004938 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 349519004939 CoA binding domain; Region: CoA_binding; pfam02629 349519004940 UGMP family protein; Validated; Region: PRK09604 349519004941 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 349519004942 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 349519004943 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 349519004944 Coenzyme A binding pocket [chemical binding]; other site 349519004945 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 349519004946 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 349519004947 Coenzyme A binding pocket [chemical binding]; other site 349519004948 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 349519004949 Glycoprotease family; Region: Peptidase_M22; pfam00814 349519004950 Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791 349519004951 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 349519004952 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 349519004953 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 349519004954 DNA binding residues [nucleotide binding] 349519004955 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 349519004956 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 349519004957 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 349519004958 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 349519004959 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 349519004960 dimerization domain swap beta strand [polypeptide binding]; other site 349519004961 regulatory protein interface [polypeptide binding]; other site 349519004962 active site 349519004963 regulatory phosphorylation site [posttranslational modification]; other site 349519004964 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 349519004965 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 349519004966 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 349519004967 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 349519004968 S-adenosylmethionine binding site [chemical binding]; other site 349519004969 peptide chain release factor 1; Validated; Region: prfA; PRK00591 349519004970 This domain is found in peptide chain release factors; Region: PCRF; smart00937 349519004971 RF-1 domain; Region: RF-1; pfam00472 349519004972 thymidine kinase; Provisional; Region: PRK04296 349519004973 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 349519004974 ATP binding site [chemical binding]; other site 349519004975 Walker A motif; other site 349519004976 Walker B motif; other site 349519004977 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 349519004978 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 349519004979 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 349519004980 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 349519004981 catalytic triad [active] 349519004982 Amino acid permease; Region: AA_permease_2; pfam13520 349519004983 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 349519004984 Peptidase C26; Region: Peptidase_C26; pfam07722 349519004985 catalytic triad [active] 349519004986 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 349519004987 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 349519004988 peptide binding site [polypeptide binding]; other site 349519004989 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 349519004990 substrate binding site [chemical binding]; other site 349519004991 THF binding site; other site 349519004992 zinc-binding site [ion binding]; other site 349519004993 S-ribosylhomocysteinase; Provisional; Region: PRK02260 349519004994 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 349519004995 substrate binding site [chemical binding]; other site 349519004996 THF binding site; other site 349519004997 zinc-binding site [ion binding]; other site 349519004998 cystathionine beta-lyase; Provisional; Region: PRK08064 349519004999 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 349519005000 homodimer interface [polypeptide binding]; other site 349519005001 substrate-cofactor binding pocket; other site 349519005002 pyridoxal 5'-phosphate binding site [chemical binding]; other site 349519005003 catalytic residue [active] 349519005004 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 349519005005 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 349519005006 homodimer interface [polypeptide binding]; other site 349519005007 substrate-cofactor binding pocket; other site 349519005008 pyridoxal 5'-phosphate binding site [chemical binding]; other site 349519005009 catalytic residue [active] 349519005010 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 349519005011 conserved cys residue [active] 349519005012 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 349519005013 catalytic residues [active] 349519005014 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 349519005015 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 349519005016 active site 349519005017 metal binding site [ion binding]; metal-binding site 349519005018 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 349519005019 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 349519005020 putative substrate translocation pore; other site 349519005021 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 349519005022 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 349519005023 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 349519005024 dimer interface [polypeptide binding]; other site 349519005025 phosphorylation site [posttranslational modification] 349519005026 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 349519005027 ATP binding site [chemical binding]; other site 349519005028 Mg2+ binding site [ion binding]; other site 349519005029 G-X-G motif; other site 349519005030 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 349519005031 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 349519005032 active site 349519005033 phosphorylation site [posttranslational modification] 349519005034 intermolecular recognition site; other site 349519005035 dimerization interface [polypeptide binding]; other site 349519005036 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 349519005037 DNA binding site [nucleotide binding] 349519005038 High-affinity nickel-transport protein; Region: NicO; cl00964 349519005039 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 349519005040 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 349519005041 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 349519005042 substrate binding site [chemical binding]; other site 349519005043 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 349519005044 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 349519005045 substrate binding site [chemical binding]; other site 349519005046 ligand binding site [chemical binding]; other site 349519005047 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 349519005048 tartrate dehydrogenase; Region: TTC; TIGR02089 349519005049 trans-homoaconitate synthase; Reviewed; Region: aksA; PRK11858 349519005050 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 349519005051 active site 349519005052 catalytic residues [active] 349519005053 metal binding site [ion binding]; metal-binding site 349519005054 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 349519005055 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 349519005056 FeS assembly protein SufB; Region: sufB; TIGR01980 349519005057 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 349519005058 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 349519005059 trimerization site [polypeptide binding]; other site 349519005060 active site 349519005061 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 349519005062 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 349519005063 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 349519005064 catalytic residue [active] 349519005065 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 349519005066 FeS assembly protein SufD; Region: sufD; TIGR01981 349519005067 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 349519005068 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 349519005069 Walker A/P-loop; other site 349519005070 ATP binding site [chemical binding]; other site 349519005071 Q-loop/lid; other site 349519005072 ABC transporter signature motif; other site 349519005073 Walker B; other site 349519005074 D-loop; other site 349519005075 H-loop/switch region; other site 349519005076 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 349519005077 salt bridge; other site 349519005078 non-specific DNA binding site [nucleotide binding]; other site 349519005079 sequence-specific DNA binding site [nucleotide binding]; other site 349519005080 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 349519005081 DEAD-like helicases superfamily; Region: DEXDc; smart00487 349519005082 ATP binding site [chemical binding]; other site 349519005083 putative Mg++ binding site [ion binding]; other site 349519005084 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 349519005085 nucleotide binding region [chemical binding]; other site 349519005086 ATP-binding site [chemical binding]; other site 349519005087 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 349519005088 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 349519005089 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 349519005090 Uncharacterized bacterial muramidase containing a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis...; Region: GH25_muramidase_2; cd06419 349519005091 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 349519005092 active site 349519005093 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 349519005094 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 349519005095 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 349519005096 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 349519005097 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 349519005098 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 349519005099 Substrate-binding site [chemical binding]; other site 349519005100 Substrate specificity [chemical binding]; other site 349519005101 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 349519005102 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 349519005103 non-specific DNA binding site [nucleotide binding]; other site 349519005104 salt bridge; other site 349519005105 sequence-specific DNA binding site [nucleotide binding]; other site 349519005106 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 349519005107 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 349519005108 NAD binding site [chemical binding]; other site 349519005109 homodimer interface [polypeptide binding]; other site 349519005110 active site 349519005111 substrate binding site [chemical binding]; other site 349519005112 Acyl-ACP thioesterase; Region: Acyl-ACP_TE; pfam01643 349519005113 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 349519005114 active site 349519005115 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 349519005116 active site 2 [active] 349519005117 active site 1 [active] 349519005118 Predicted methyltransferases [General function prediction only]; Region: COG0313 349519005119 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 349519005120 putative SAM binding site [chemical binding]; other site 349519005121 putative homodimer interface [polypeptide binding]; other site 349519005122 DNA polymerase III subunit delta'; Validated; Region: PRK08058 349519005123 DNA polymerase III subunit delta'; Validated; Region: PRK08485 349519005124 Protein of unknown function (DUF970); Region: DUF970; cl17525 349519005125 thymidylate kinase; Validated; Region: tmk; PRK00698 349519005126 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 349519005127 TMP-binding site; other site 349519005128 ATP-binding site [chemical binding]; other site 349519005129 Protein of unknown function (DUF2508); Region: DUF2508; pfam10704 349519005130 recombination protein RecR; Reviewed; Region: recR; PRK00076 349519005131 RecR protein; Region: RecR; pfam02132 349519005132 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 349519005133 putative active site [active] 349519005134 putative metal-binding site [ion binding]; other site 349519005135 tetramer interface [polypeptide binding]; other site 349519005136 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 349519005137 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 349519005138 Walker A motif; other site 349519005139 ATP binding site [chemical binding]; other site 349519005140 Walker B motif; other site 349519005141 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 349519005142 Zn2+ binding site [ion binding]; other site 349519005143 Mg2+ binding site [ion binding]; other site 349519005144 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 349519005145 nucleoside/Zn binding site; other site 349519005146 dimer interface [polypeptide binding]; other site 349519005147 catalytic motif [active] 349519005148 Methyltransferase domain; Region: Methyltransf_31; pfam13847 349519005149 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 349519005150 S-adenosylmethionine binding site [chemical binding]; other site 349519005151 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 349519005152 peripheral dimer interface [polypeptide binding]; other site 349519005153 core dimer interface [polypeptide binding]; other site 349519005154 L10 interface [polypeptide binding]; other site 349519005155 L11 interface [polypeptide binding]; other site 349519005156 putative EF-Tu interaction site [polypeptide binding]; other site 349519005157 putative EF-G interaction site [polypeptide binding]; other site 349519005158 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 349519005159 23S rRNA interface [nucleotide binding]; other site 349519005160 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 349519005161 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 349519005162 mRNA/rRNA interface [nucleotide binding]; other site 349519005163 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 349519005164 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 349519005165 putative thiostrepton binding site; other site 349519005166 23S rRNA interface [nucleotide binding]; other site 349519005167 L7/L12 interface [polypeptide binding]; other site 349519005168 L25 interface [polypeptide binding]; other site 349519005169 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 349519005170 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 349519005171 putative homodimer interface [polypeptide binding]; other site 349519005172 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 349519005173 heterodimer interface [polypeptide binding]; other site 349519005174 homodimer interface [polypeptide binding]; other site 349519005175 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 349519005176 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 349519005177 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 349519005178 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 349519005179 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 349519005180 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 349519005181 30S subunit binding site; other site 349519005182 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 349519005183 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 349519005184 active site 349519005185 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 349519005186 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 349519005187 ATP binding site [chemical binding]; other site 349519005188 putative Mg++ binding site [ion binding]; other site 349519005189 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 349519005190 nucleotide binding region [chemical binding]; other site 349519005191 ATP-binding site [chemical binding]; other site 349519005192 Uncharacterized conserved protein [Function unknown]; Region: COG1739 349519005193 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 349519005194 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 349519005195 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 349519005196 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_2; cd12172 349519005197 putative ligand binding site [chemical binding]; other site 349519005198 putative NAD binding site [chemical binding]; other site 349519005199 catalytic site [active] 349519005200 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 349519005201 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 349519005202 substrate binding site [chemical binding]; other site 349519005203 ATP binding site [chemical binding]; other site 349519005204 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 349519005205 Transcriptional regulators [Transcription]; Region: PurR; COG1609 349519005206 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 349519005207 DNA binding site [nucleotide binding] 349519005208 domain linker motif; other site 349519005209 Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283 349519005210 putative dimerization interface [polypeptide binding]; other site 349519005211 putative ligand binding site [chemical binding]; other site 349519005212 exopolyphosphatase; Region: exo_poly_only; TIGR03706 349519005213 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 349519005214 polyphosphate kinase; Provisional; Region: PRK05443 349519005215 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 349519005216 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 349519005217 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 349519005218 putative domain interface [polypeptide binding]; other site 349519005219 putative active site [active] 349519005220 catalytic site [active] 349519005221 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 349519005222 putative domain interface [polypeptide binding]; other site 349519005223 putative active site [active] 349519005224 catalytic site [active] 349519005225 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 349519005226 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 349519005227 Zn2+ binding site [ion binding]; other site 349519005228 Mg2+ binding site [ion binding]; other site 349519005229 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 349519005230 enolase; Provisional; Region: eno; PRK00077 349519005231 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 349519005232 dimer interface [polypeptide binding]; other site 349519005233 metal binding site [ion binding]; metal-binding site 349519005234 substrate binding pocket [chemical binding]; other site 349519005235 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 349519005236 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 349519005237 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 349519005238 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 349519005239 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 349519005240 Ribonuclease III family protein [Replication, recombination, and repair]; Region: COG1939 349519005241 active site 349519005242 metal binding site [ion binding]; metal-binding site 349519005243 dimerization interface [polypeptide binding]; other site 349519005244 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 349519005245 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 349519005246 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 349519005247 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 349519005248 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 349519005249 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 349519005250 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 349519005251 DNA binding site [nucleotide binding] 349519005252 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 349519005253 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 349519005254 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 349519005255 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 349519005256 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 349519005257 RPB1 interaction site [polypeptide binding]; other site 349519005258 RPB10 interaction site [polypeptide binding]; other site 349519005259 RPB11 interaction site [polypeptide binding]; other site 349519005260 RPB3 interaction site [polypeptide binding]; other site 349519005261 RPB12 interaction site [polypeptide binding]; other site 349519005262 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 349519005263 triosephosphate isomerase; Provisional; Region: PRK14565 349519005264 substrate binding site [chemical binding]; other site 349519005265 dimer interface [polypeptide binding]; other site 349519005266 catalytic triad [active] 349519005267 rod shape-determining protein MreC; Provisional; Region: PRK13922 349519005268 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 349519005269 DNA-binding site [nucleotide binding]; DNA binding site 349519005270 RNA-binding motif; other site 349519005271 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 349519005272 catalytic core [active] 349519005273 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 349519005274 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 349519005275 active site 349519005276 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 349519005277 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 349519005278 dimer interface [polypeptide binding]; other site 349519005279 putative radical transfer pathway; other site 349519005280 diiron center [ion binding]; other site 349519005281 tyrosyl radical; other site 349519005282 NrdI Flavodoxin like; Region: Flavodoxin_NdrI; cl17293 349519005283 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07306 349519005284 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 349519005285 Class I ribonucleotide reductase; Region: RNR_I; cd01679 349519005286 active site 349519005287 dimer interface [polypeptide binding]; other site 349519005288 catalytic residues [active] 349519005289 effector binding site; other site 349519005290 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 349519005291 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 349519005292 catalytic residues [active] 349519005293 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 349519005294 Domain of unknown function DUF21; Region: DUF21; pfam01595 349519005295 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 349519005296 Transporter associated domain; Region: CorC_HlyC; smart01091 349519005297 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 349519005298 catalytic core [active] 349519005299 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 349519005300 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 349519005301 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 349519005302 HflX GTPase family; Region: HflX; cd01878 349519005303 G1 box; other site 349519005304 GTP/Mg2+ binding site [chemical binding]; other site 349519005305 Switch I region; other site 349519005306 G2 box; other site 349519005307 G3 box; other site 349519005308 Switch II region; other site 349519005309 G4 box; other site 349519005310 G5 box; other site 349519005311 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 349519005312 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 349519005313 23S rRNA interface [nucleotide binding]; other site 349519005314 L3 interface [polypeptide binding]; other site 349519005315 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 349519005316 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 349519005317 dimerization interface 3.5A [polypeptide binding]; other site 349519005318 active site 349519005319 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 349519005320 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634 349519005321 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 349519005322 Walker A/P-loop; other site 349519005323 ATP binding site [chemical binding]; other site 349519005324 Q-loop/lid; other site 349519005325 ABC transporter signature motif; other site 349519005326 Walker B; other site 349519005327 D-loop; other site 349519005328 H-loop/switch region; other site 349519005329 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635 349519005330 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 349519005331 Walker A/P-loop; other site 349519005332 ATP binding site [chemical binding]; other site 349519005333 Q-loop/lid; other site 349519005334 ABC transporter signature motif; other site 349519005335 Walker B; other site 349519005336 D-loop; other site 349519005337 H-loop/switch region; other site 349519005338 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 349519005339 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 349519005340 Predicted membrane protein [Function unknown]; Region: COG2259 349519005341 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 349519005342 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 349519005343 substrate binding pocket [chemical binding]; other site 349519005344 chain length determination region; other site 349519005345 substrate-Mg2+ binding site; other site 349519005346 catalytic residues [active] 349519005347 aspartate-rich region 1; other site 349519005348 active site lid residues [active] 349519005349 aspartate-rich region 2; other site 349519005350 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 349519005351 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 349519005352 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 349519005353 alphaNTD - beta interaction site [polypeptide binding]; other site 349519005354 alphaNTD homodimer interface [polypeptide binding]; other site 349519005355 alphaNTD - beta' interaction site [polypeptide binding]; other site 349519005356 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 349519005357 30S ribosomal protein S11; Validated; Region: PRK05309 349519005358 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 349519005359 30S ribosomal protein S13; Region: bact_S13; TIGR03631 349519005360 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 349519005361 rRNA binding site [nucleotide binding]; other site 349519005362 predicted 30S ribosome binding site; other site 349519005363 adenylate kinase; Reviewed; Region: adk; PRK00279 349519005364 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 349519005365 AMP-binding site [chemical binding]; other site 349519005366 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 349519005367 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 349519005368 SecY translocase; Region: SecY; pfam00344 349519005369 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 349519005370 50S ribosomal protein L30; Reviewed; Region: rpmD; PRK05611 349519005371 23S rRNA binding site - archaea [nucleotide binding]; other site 349519005372 23S rRNA binding site - prokaryotes [nucleotide binding]; other site 349519005373 5S rRNA binding site - archaea; other site 349519005374 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 349519005375 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 349519005376 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 349519005377 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 349519005378 5S rRNA interface [nucleotide binding]; other site 349519005379 L27 interface [polypeptide binding]; other site 349519005380 23S rRNA interface [nucleotide binding]; other site 349519005381 L5 interface [polypeptide binding]; other site 349519005382 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 349519005383 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 349519005384 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 349519005385 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 349519005386 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 349519005387 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 349519005388 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 349519005389 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 349519005390 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 349519005391 RNA binding site [nucleotide binding]; other site 349519005392 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 349519005393 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 349519005394 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 349519005395 putative translocon interaction site; other site 349519005396 23S rRNA interface [nucleotide binding]; other site 349519005397 signal recognition particle (SRP54) interaction site; other site 349519005398 L23 interface [polypeptide binding]; other site 349519005399 trigger factor interaction site; other site 349519005400 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 349519005401 23S rRNA interface [nucleotide binding]; other site 349519005402 5S rRNA interface [nucleotide binding]; other site 349519005403 putative antibiotic binding site [chemical binding]; other site 349519005404 L25 interface [polypeptide binding]; other site 349519005405 L27 interface [polypeptide binding]; other site 349519005406 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 349519005407 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 349519005408 G-X-X-G motif; other site 349519005409 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 349519005410 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 349519005411 putative translocon binding site; other site 349519005412 protein-rRNA interface [nucleotide binding]; other site 349519005413 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 349519005414 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 349519005415 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 349519005416 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 349519005417 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 349519005418 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 349519005419 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 349519005420 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 349519005421 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 349519005422 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 349519005423 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 349519005424 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 349519005425 dimer interface [polypeptide binding]; other site 349519005426 conserved gate region; other site 349519005427 putative PBP binding loops; other site 349519005428 ABC-ATPase subunit interface; other site 349519005429 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 349519005430 dimer interface [polypeptide binding]; other site 349519005431 conserved gate region; other site 349519005432 putative PBP binding loops; other site 349519005433 ABC-ATPase subunit interface; other site 349519005434 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 349519005435 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 349519005436 Walker A/P-loop; other site 349519005437 ATP binding site [chemical binding]; other site 349519005438 Q-loop/lid; other site 349519005439 ABC transporter signature motif; other site 349519005440 Walker B; other site 349519005441 D-loop; other site 349519005442 H-loop/switch region; other site 349519005443 TOBE domain; Region: TOBE_2; pfam08402 349519005444 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 349519005445 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 349519005446 putative substrate translocation pore; other site 349519005447 elongation factor G; Reviewed; Region: PRK12739 349519005448 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 349519005449 G1 box; other site 349519005450 putative GEF interaction site [polypeptide binding]; other site 349519005451 GTP/Mg2+ binding site [chemical binding]; other site 349519005452 Switch I region; other site 349519005453 G2 box; other site 349519005454 G3 box; other site 349519005455 Switch II region; other site 349519005456 G4 box; other site 349519005457 G5 box; other site 349519005458 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 349519005459 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 349519005460 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 349519005461 30S ribosomal protein S7; Validated; Region: PRK05302 349519005462 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 349519005463 S17 interaction site [polypeptide binding]; other site 349519005464 S8 interaction site; other site 349519005465 16S rRNA interaction site [nucleotide binding]; other site 349519005466 streptomycin interaction site [chemical binding]; other site 349519005467 23S rRNA interaction site [nucleotide binding]; other site 349519005468 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 349519005469 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 349519005470 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 349519005471 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 349519005472 Clp amino terminal domain; Region: Clp_N; pfam02861 349519005473 Clp amino terminal domain; Region: Clp_N; pfam02861 349519005474 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 349519005475 Walker A motif; other site 349519005476 ATP binding site [chemical binding]; other site 349519005477 Walker B motif; other site 349519005478 arginine finger; other site 349519005479 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 349519005480 Walker A motif; other site 349519005481 ATP binding site [chemical binding]; other site 349519005482 Walker B motif; other site 349519005483 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 349519005484 peptide chain release factor 2; Validated; Region: prfB; PRK00578 349519005485 Chibby, a nuclear inhibitor of Wnt/beta-catenin mediated transcription, and similar proteins; Region: Cby_like; cd07429 349519005486 This domain is found in peptide chain release factors; Region: PCRF; smart00937 349519005487 RF-1 domain; Region: RF-1; pfam00472 349519005488 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 349519005489 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 349519005490 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 349519005491 seryl-tRNA synthetase; Provisional; Region: PRK05431 349519005492 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 349519005493 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 349519005494 dimer interface [polypeptide binding]; other site 349519005495 active site 349519005496 motif 1; other site 349519005497 motif 2; other site 349519005498 motif 3; other site 349519005499 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 349519005500 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 349519005501 active site 349519005502 HIGH motif; other site 349519005503 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 349519005504 KMSKS motif; other site 349519005505 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 349519005506 tRNA binding surface [nucleotide binding]; other site 349519005507 anticodon binding site; other site 349519005508 Phosphoglycerate kinase; Region: PGK; pfam00162 349519005509 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 349519005510 substrate binding site [chemical binding]; other site 349519005511 hinge regions; other site 349519005512 ADP binding site [chemical binding]; other site 349519005513 catalytic site [active] 349519005514 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 349519005515 accessory Sec system glycosylation protein GtfA; Region: TIGR02918 349519005516 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 349519005517 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 349519005518 Major Facilitator Superfamily; Region: MFS_1; pfam07690 349519005519 putative substrate translocation pore; other site 349519005520 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 349519005521 pantothenate kinase; Provisional; Region: PRK05439 349519005522 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 349519005523 active site 349519005524 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 349519005525 Part of AAA domain; Region: AAA_19; pfam13245 349519005526 Family description; Region: UvrD_C_2; pfam13538 349519005527 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 349519005528 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 349519005529 putative active site [active] 349519005530 putative FMN binding site [chemical binding]; other site 349519005531 putative substrate binding site [chemical binding]; other site 349519005532 putative catalytic residue [active] 349519005533 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 349519005534 non-specific DNA binding site [nucleotide binding]; other site 349519005535 salt bridge; other site 349519005536 sequence-specific DNA binding site [nucleotide binding]; other site 349519005537 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 349519005538 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 349519005539 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 349519005540 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 349519005541 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 349519005542 active site 349519005543 metal binding site [ion binding]; metal-binding site 349519005544 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 349519005545 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 349519005546 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 349519005547 dimer interface [polypeptide binding]; other site 349519005548 conserved gate region; other site 349519005549 ABC-ATPase subunit interface; other site 349519005550 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 349519005551 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 349519005552 dimer interface [polypeptide binding]; other site 349519005553 conserved gate region; other site 349519005554 putative PBP binding loops; other site 349519005555 ABC-ATPase subunit interface; other site 349519005556 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 349519005557 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 349519005558 Walker A/P-loop; other site 349519005559 ATP binding site [chemical binding]; other site 349519005560 Q-loop/lid; other site 349519005561 ABC transporter signature motif; other site 349519005562 Walker B; other site 349519005563 D-loop; other site 349519005564 H-loop/switch region; other site 349519005565 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 349519005566 High affinity transport system protein p37; Region: Mycoplasma_p37; pfam06646 349519005567 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 349519005568 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 349519005569 gamma subunit interface [polypeptide binding]; other site 349519005570 epsilon subunit interface [polypeptide binding]; other site 349519005571 LBP interface [polypeptide binding]; other site 349519005572 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 349519005573 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 349519005574 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 349519005575 alpha subunit interaction interface [polypeptide binding]; other site 349519005576 Walker A motif; other site 349519005577 ATP binding site [chemical binding]; other site 349519005578 Walker B motif; other site 349519005579 inhibitor binding site; inhibition site 349519005580 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 349519005581 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 349519005582 core domain interface [polypeptide binding]; other site 349519005583 delta subunit interface [polypeptide binding]; other site 349519005584 epsilon subunit interface [polypeptide binding]; other site 349519005585 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 349519005586 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 349519005587 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 349519005588 beta subunit interaction interface [polypeptide binding]; other site 349519005589 Walker A motif; other site 349519005590 ATP binding site [chemical binding]; other site 349519005591 Walker B motif; other site 349519005592 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 349519005593 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 349519005594 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 349519005595 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 349519005596 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 349519005597 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 349519005598 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 349519005599 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 349519005600 uracil transporter; Provisional; Region: PRK10720 349519005601 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 349519005602 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 349519005603 G1 box; other site 349519005604 putative GEF interaction site [polypeptide binding]; other site 349519005605 GTP/Mg2+ binding site [chemical binding]; other site 349519005606 Switch I region; other site 349519005607 G2 box; other site 349519005608 G3 box; other site 349519005609 Switch II region; other site 349519005610 G4 box; other site 349519005611 G5 box; other site 349519005612 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 349519005613 Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124 349519005614 active site 349519005615 zinc binding site [ion binding]; other site 349519005616 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 349519005617 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 349519005618 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 349519005619 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 349519005620 EDD domain protein, DegV family; Region: DegV; TIGR00762 349519005621 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 349519005622 CrcB-like protein; Region: CRCB; pfam02537 349519005623 CrcB-like protein; Region: CRCB; pfam02537 349519005624 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 349519005625 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 349519005626 transmembrane helices; other site 349519005627 L-aspartate oxidase; Provisional; Region: PRK06175 349519005628 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 349519005629 L-aspartate oxidase; Provisional; Region: PRK06175 349519005630 fumarate hydratase; Reviewed; Region: fumC; PRK00485 349519005631 Class II fumarases; Region: Fumarase_classII; cd01362 349519005632 active site 349519005633 tetramer interface [polypeptide binding]; other site 349519005634 Transcriptional regulator [Transcription]; Region: LysR; COG0583 349519005635 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 349519005636 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 349519005637 dimerization interface [polypeptide binding]; other site 349519005638 PAS domain; Region: PAS_10; pfam13596 349519005639 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 349519005640 ApbE family; Region: ApbE; pfam02424 349519005641 Predicted flavoprotein [General function prediction only]; Region: COG0431 349519005642 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 349519005643 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 349519005644 zinc binding site [ion binding]; other site 349519005645 putative ligand binding site [chemical binding]; other site 349519005646 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 349519005647 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 349519005648 TM-ABC transporter signature motif; other site 349519005649 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 349519005650 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 349519005651 Walker A/P-loop; other site 349519005652 ATP binding site [chemical binding]; other site 349519005653 Q-loop/lid; other site 349519005654 ABC transporter signature motif; other site 349519005655 Walker B; other site 349519005656 D-loop; other site 349519005657 H-loop/switch region; other site 349519005658 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 349519005659 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 349519005660 tetramer (dimer of dimers) interface [polypeptide binding]; other site 349519005661 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 349519005662 NAD binding site [chemical binding]; other site 349519005663 dimer interface [polypeptide binding]; other site 349519005664 substrate binding site [chemical binding]; other site 349519005665 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 349519005666 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 349519005667 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 349519005668 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 349519005669 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 349519005670 TM-ABC transporter signature motif; other site 349519005671 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 349519005672 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 349519005673 TM-ABC transporter signature motif; other site 349519005674 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 349519005675 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 349519005676 Walker A/P-loop; other site 349519005677 ATP binding site [chemical binding]; other site 349519005678 Q-loop/lid; other site 349519005679 ABC transporter signature motif; other site 349519005680 Walker B; other site 349519005681 D-loop; other site 349519005682 H-loop/switch region; other site 349519005683 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 349519005684 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 349519005685 Enterocin A Immunity; Region: EntA_Immun; pfam08951 349519005686 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 349519005687 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 349519005688 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 349519005689 TrkA-N domain; Region: TrkA_N; pfam02254 349519005690 TrkA-C domain; Region: TrkA_C; pfam02080 349519005691 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 349519005692 Protein of unknown function (DUF2974); Region: DUF2974; pfam11187 349519005693 OsmC-like protein; Region: OsmC; cl00767 349519005694 Predicted transcriptional regulators [Transcription]; Region: COG1695 349519005695 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 349519005696 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 349519005697 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 349519005698 putative substrate translocation pore; other site 349519005699 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 349519005700 Predicted transcriptional regulator [Transcription]; Region: COG2378 349519005701 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 349519005702 substrate binding site [chemical binding]; other site 349519005703 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 349519005704 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 349519005705 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 349519005706 heterotetramer interface [polypeptide binding]; other site 349519005707 active site pocket [active] 349519005708 cleavage site 349519005709 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 349519005710 nucleotide binding site [chemical binding]; other site 349519005711 N-acetyl-L-glutamate binding site [chemical binding]; other site 349519005712 acetylornithine aminotransferase; Provisional; Region: argD; PRK02936 349519005713 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 349519005714 inhibitor-cofactor binding pocket; inhibition site 349519005715 pyridoxal 5'-phosphate binding site [chemical binding]; other site 349519005716 catalytic residue [active] 349519005717 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 349519005718 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 349519005719 S-adenosylmethionine binding site [chemical binding]; other site 349519005720 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK03640 349519005721 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 349519005722 acyl-activating enzyme (AAE) consensus motif; other site 349519005723 putative AMP binding site [chemical binding]; other site 349519005724 putative active site [active] 349519005725 putative CoA binding site [chemical binding]; other site 349519005726 copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698 349519005727 Penicillinase repressor; Region: Pencillinase_R; pfam03965 349519005728 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 349519005729 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 349519005730 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 349519005731 Protein of unknown function (DUF1003); Region: DUF1003; pfam06210 349519005732 GntP family permease; Region: GntP_permease; pfam02447 349519005733 fructuronate transporter; Provisional; Region: PRK10034; cl15264 349519005734 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 349519005735 amphipathic channel; other site 349519005736 Asn-Pro-Ala signature motifs; other site 349519005737 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 349519005738 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 349519005739 active site 349519005740 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 349519005741 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 349519005742 DNA binding residues [nucleotide binding] 349519005743 putative dimer interface [polypeptide binding]; other site 349519005744 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 349519005745 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 349519005746 putative ADP-binding pocket [chemical binding]; other site 349519005747 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 349519005748 Sulfatase; Region: Sulfatase; pfam00884 349519005749 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 349519005750 Coenzyme A binding pocket [chemical binding]; other site 349519005751 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 349519005752 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 349519005753 active site 349519005754 motif I; other site 349519005755 motif II; other site 349519005756 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 349519005757 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 349519005758 Major Facilitator Superfamily; Region: MFS_1; pfam07690 349519005759 putative substrate translocation pore; other site 349519005760 transaminase; Reviewed; Region: PRK08068 349519005761 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 349519005762 pyridoxal 5'-phosphate binding site [chemical binding]; other site 349519005763 homodimer interface [polypeptide binding]; other site 349519005764 catalytic residue [active] 349519005765 Predicted amidohydrolase [General function prediction only]; Region: COG0388 349519005766 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 349519005767 putative active site [active] 349519005768 catalytic triad [active] 349519005769 putative dimer interface [polypeptide binding]; other site 349519005770 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 349519005771 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 349519005772 substrate binding site [chemical binding]; other site 349519005773 oxyanion hole (OAH) forming residues; other site 349519005774 trimer interface [polypeptide binding]; other site 349519005775 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 349519005776 CoenzymeA binding site [chemical binding]; other site 349519005777 subunit interaction site [polypeptide binding]; other site 349519005778 PHB binding site; other site 349519005779 accessory Sec system protein Asp3; Region: acc_sec_asp3; TIGR03711 349519005780 accessory Sec system protein Asp2; Region: acc_sec_asp2; TIGR03712 349519005781 accessory Sec system protein Asp1; Region: acc_sec_asp1; TIGR03713 349519005782 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 349519005783 Coenzyme A binding pocket [chemical binding]; other site 349519005784 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 349519005785 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 349519005786 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 349519005787 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 349519005788 dimer interface [polypeptide binding]; other site 349519005789 active site 349519005790 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 349519005791 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 349519005792 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 349519005793 acyl-activating enzyme (AAE) consensus motif; other site 349519005794 acyl-activating enzyme (AAE) consensus motif; other site 349519005795 AMP binding site [chemical binding]; other site 349519005796 active site 349519005797 CoA binding site [chemical binding]; other site 349519005798 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 349519005799 active site 349519005800 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 349519005801 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 349519005802 Cl binding site [ion binding]; other site 349519005803 oligomer interface [polypeptide binding]; other site 349519005804 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 349519005805 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 349519005806 Coenzyme A binding pocket [chemical binding]; other site 349519005807 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; cl01974 349519005808 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 349519005809 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 349519005810 putative active site [active] 349519005811 catalytic site [active] 349519005812 putative metal binding site [ion binding]; other site 349519005813 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 349519005814 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 349519005815 ribonuclease P; Reviewed; Region: rnpA; PRK00499 349519005816 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 349519005817 hypothetical protein; Provisional; Region: PRK12378 349519005818 Pseudouridine synthase, Escherichia coli RluE; Region: PseudoU_synth_RluE; cd02566 349519005819 pseudouridine synthase; Region: TIGR00093 349519005820 probable active site [active]