-- dump date   	20140619_131630
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
979982000001	Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032
979982000002	ArsC family; Region: ArsC; pfam03960
979982000003	putative catalytic residues [active]
979982000004	thiol/disulfide switch; other site
979982000005	adaptor protein; Provisional; Region: PRK02315
979982000006	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
979982000007	active site residue [active]
979982000008	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
979982000009	lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545
979982000010	Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437
979982000011	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181
979982000012	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
979982000013	tetramer interface [polypeptide binding]; other site
979982000014	TPP-binding site [chemical binding]; other site
979982000015	heterodimer interface [polypeptide binding]; other site
979982000016	phosphorylation loop region [posttranslational modification]
979982000017	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
979982000018	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
979982000019	alpha subunit interface [polypeptide binding]; other site
979982000020	TPP binding site [chemical binding]; other site
979982000021	heterodimer interface [polypeptide binding]; other site
979982000022	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
979982000023	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
979982000024	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
979982000025	E3 interaction surface; other site
979982000026	lipoyl attachment site [posttranslational modification]; other site
979982000027	e3 binding domain; Region: E3_binding; pfam02817
979982000028	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
979982000029	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
979982000030	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
979982000031	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
979982000032	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
979982000033	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
979982000034	Protein of unknown function (DUF3042); Region: DUF3042; pfam11240
979982000035	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
979982000036	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
979982000037	active site
979982000038	catalytic site [active]
979982000039	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
979982000040	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
979982000041	N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259
979982000042	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
979982000043	Transcriptional regulators [Transcription]; Region: PurR; COG1609
979982000044	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
979982000045	DNA binding site [nucleotide binding]
979982000046	domain linker motif; other site
979982000047	Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283
979982000048	putative dimerization interface [polypeptide binding]; other site
979982000049	putative ligand binding site [chemical binding]; other site
979982000050	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
979982000051	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
979982000052	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
979982000053	substrate binding site [chemical binding]; other site
979982000054	ATP binding site [chemical binding]; other site
979982000055	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
979982000056	Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_2; cd12172
979982000057	putative ligand binding site [chemical binding]; other site
979982000058	putative NAD binding site [chemical binding]; other site
979982000059	catalytic site [active]
979982000060	Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601
979982000061	Aminopeptidase N [Amino acid transport and metabolism]; Region: PepN; COG0308
979982000062	Zn binding site [ion binding]; other site
979982000063	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
979982000064	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
979982000065	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
979982000066	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
979982000067	ATP binding site [chemical binding]; other site
979982000068	putative Mg++ binding site [ion binding]; other site
979982000069	EcoKI restriction-modification system protein HsdS; Provisional; Region: PRK09737
979982000070	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
979982000071	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
979982000072	GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257
979982000073	GIY-YIG motif/motif A; other site
979982000074	active site
979982000075	catalytic site [active]
979982000076	metal binding site [ion binding]; metal-binding site
979982000077	HsdM N-terminal domain; Region: HsdM_N; pfam12161
979982000078	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
979982000079	Methyltransferase domain; Region: Methyltransf_26; pfam13659
979982000080	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
979982000081	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
979982000082	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
979982000083	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
979982000084	Int/Topo IB signature motif; other site
979982000085	benzoate transport; Region: 2A0115; TIGR00895
979982000086	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
979982000087	putative substrate translocation pore; other site
979982000088	x-prolyl-dipeptidyl aminopeptidase; Provisional; Region: PRK05371
979982000089	X-Prolyl dipeptidyl aminopeptidase PepX, N-terminal; Region: PepX_N; cl07696
979982000090	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
979982000091	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530
979982000092	HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078
979982000093	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
979982000094	Zn2+ binding site [ion binding]; other site
979982000095	Mg2+ binding site [ion binding]; other site
979982000096	Domain of unknown function (DUF1934); Region: DUF1934; pfam09148
979982000097	DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066
979982000098	putative transport protein YifK; Provisional; Region: PRK10746
979982000099	putative phosphate acyltransferase; Provisional; Region: PRK05331
979982000100	acyl carrier protein; Provisional; Region: acpP; PRK00982
979982000101	GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956
979982000102	GAF domain; Region: GAF_2; pfam13185
979982000103	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
979982000104	ABC-ATPase subunit interface; other site
979982000105	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
979982000106	SprT homologues; Region: SprT; cl01182
979982000107	hypothetical protein; Provisional; Region: PRK04351
979982000108	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
979982000109	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
979982000110	active site
979982000111	motif I; other site
979982000112	motif II; other site
979982000113	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
979982000114	CAAX protease self-immunity; Region: Abi; pfam02517
979982000115	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
979982000116	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
979982000117	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
979982000118	active site
979982000119	catabolite control protein A; Region: ccpA; TIGR01481
979982000120	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
979982000121	DNA binding site [nucleotide binding]
979982000122	domain linker motif; other site
979982000123	Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298
979982000124	dimerization interface [polypeptide binding]; other site
979982000125	effector binding site; other site
979982000126	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
979982000127	yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840
979982000128	catalytic triad [active]
979982000129	catalytic triad [active]
979982000130	oxyanion hole [active]
979982000131	Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306
979982000132	Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572
979982000133	Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023
979982000134	Sugar specificity; other site
979982000135	Pyrimidine base specificity; other site
979982000136	ATP-binding site [chemical binding]; other site
979982000137	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
979982000138	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
979982000139	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
979982000140	putative active site [active]
979982000141	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
979982000142	Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023
979982000143	gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314
979982000144	Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770
979982000145	N- and C-terminal domain interface [polypeptide binding]; other site
979982000146	active site
979982000147	catalytic site [active]
979982000148	metal binding site [ion binding]; metal-binding site
979982000149	carbohydrate binding site [chemical binding]; other site
979982000150	ATP binding site [chemical binding]; other site
979982000151	GntP family permease; Region: GntP_permease; pfam02447
979982000152	fructuronate transporter; Provisional; Region: PRK10034; cl15264
979982000153	amino acid transporter; Region: 2A0306; TIGR00909
979982000154	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
979982000155	4-aminobutyrate aminotransferase; Provisional; Region: PRK08593
979982000156	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
979982000157	inhibitor-cofactor binding pocket; inhibition site
979982000158	pyridoxal 5'-phosphate binding site [chemical binding]; other site
979982000159	catalytic residue [active]
979982000160	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
979982000161	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
979982000162	motif 1; other site
979982000163	active site
979982000164	motif 2; other site
979982000165	motif 3; other site
979982000166	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
979982000167	DHHA1 domain; Region: DHHA1; pfam02272
979982000168	hypothetical protein; Provisional; Region: PRK05473
979982000169	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
979982000170	hypothetical protein; Provisional; Region: PRK13678
979982000171	cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097
979982000172	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
979982000173	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
979982000174	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
979982000175	ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988
979982000176	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
979982000177	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
979982000178	Walker A/P-loop; other site
979982000179	ATP binding site [chemical binding]; other site
979982000180	Q-loop/lid; other site
979982000181	ABC transporter signature motif; other site
979982000182	Walker B; other site
979982000183	D-loop; other site
979982000184	H-loop/switch region; other site
979982000185	ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987
979982000186	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
979982000187	ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247
979982000188	Walker A/P-loop; other site
979982000189	ATP binding site [chemical binding]; other site
979982000190	Q-loop/lid; other site
979982000191	ABC transporter signature motif; other site
979982000192	Walker B; other site
979982000193	D-loop; other site
979982000194	H-loop/switch region; other site
979982000195	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832
979982000196	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
979982000197	Part of AAA domain; Region: AAA_19; pfam13245
979982000198	Family description; Region: UvrD_C_2; pfam13538
979982000199	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
979982000200	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
979982000201	nucleotide binding pocket [chemical binding]; other site
979982000202	K-X-D-G motif; other site
979982000203	catalytic site [active]
979982000204	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
979982000205	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
979982000206	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
979982000207	Dimer interface [polypeptide binding]; other site
979982000208	N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441
979982000209	putative dimer interface [polypeptide binding]; other site
979982000210	CamS sex pheromone cAM373 precursor; Region: CamS; pfam07537
979982000211	C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440
979982000212	putative dimer interface [polypeptide binding]; other site
979982000213	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
979982000214	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
979982000215	generic binding surface II; other site
979982000216	generic binding surface I; other site
979982000217	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
979982000218	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
979982000219	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
979982000220	substrate binding pocket [chemical binding]; other site
979982000221	chain length determination region; other site
979982000222	catalytic residues [active]
979982000223	aspartate-rich region 1; other site
979982000224	substrate-Mg2+ binding site; other site
979982000225	active site lid residues [active]
979982000226	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
979982000227	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
979982000228	RNA binding surface [nucleotide binding]; other site
979982000229	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
979982000230	S-adenosylmethionine binding site [chemical binding]; other site
979982000231	Arginine repressor [Transcription]; Region: ArgR; COG1438
979982000232	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
979982000233	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
979982000234	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
979982000235	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
979982000236	Walker A/P-loop; other site
979982000237	ATP binding site [chemical binding]; other site
979982000238	Q-loop/lid; other site
979982000239	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
979982000240	ABC transporter signature motif; other site
979982000241	Walker B; other site
979982000242	D-loop; other site
979982000243	H-loop/switch region; other site
979982000244	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
979982000245	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
979982000246	catalytic core [active]
979982000247	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
979982000248	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
979982000249	M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656
979982000250	oligomer interface [polypeptide binding]; other site
979982000251	active site
979982000252	metal binding site [ion binding]; metal-binding site
979982000253	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
979982000254	Uncharacterized protein conserved in bacteria (DUF2129); Region: DUF2129; pfam09902
979982000255	Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602
979982000256	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
979982000257	S-adenosylmethionine binding site [chemical binding]; other site
979982000258	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
979982000259	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
979982000260	active site
979982000261	(T/H)XGH motif; other site
979982000262	Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480
979982000263	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117
979982000264	protein binding site [polypeptide binding]; other site
979982000265	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
979982000266	NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171
979982000267	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
979982000268	homodimer interface [polypeptide binding]; other site
979982000269	NAD binding pocket [chemical binding]; other site
979982000270	ATP binding pocket [chemical binding]; other site
979982000271	Mg binding site [ion binding]; other site
979982000272	active-site loop [active]
979982000273	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
979982000274	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
979982000275	active site
979982000276	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
979982000277	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
979982000278	an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130
979982000279	active site
979982000280	catalytic site [active]
979982000281	substrate binding site [chemical binding]; other site
979982000282	Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087
979982000283	active site
979982000284	putative catalytic site [active]
979982000285	DNA binding site [nucleotide binding]
979982000286	putative phosphate binding site [ion binding]; other site
979982000287	metal binding site A [ion binding]; metal-binding site
979982000288	AP binding site [nucleotide binding]; other site
979982000289	metal binding site B [ion binding]; metal-binding site
979982000290	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
979982000291	putative substrate binding site [chemical binding]; other site
979982000292	putative ATP binding site [chemical binding]; other site
979982000293	dipeptidase PepV; Reviewed; Region: PRK07318
979982000294	M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888
979982000295	active site
979982000296	metal binding site [ion binding]; metal-binding site
979982000297	methionine sulfoxide reductase B; Provisional; Region: PRK00222
979982000298	SelR domain; Region: SelR; pfam01641
979982000299	Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973
979982000300	nicotinamide-nucleotide adenylyltransferase, NadR type; Region: nadR_NMN_Atrans; TIGR01526
979982000301	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
979982000302	active site
979982000303	nucleotide binding site [chemical binding]; other site
979982000304	HIGH motif; other site
979982000305	KMSKS motif; other site
979982000306	Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172
979982000307	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
979982000308	acetoin reductases; Region: 23BDH; TIGR02415
979982000309	NAD(P) binding site [chemical binding]; other site
979982000310	active site
979982000311	FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263
979982000312	Bacteriophage peptidoglycan hydrolase; Region: Amidase_5; pfam05382
979982000313	trigger factor; Provisional; Region: tig; PRK01490
979982000314	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
979982000315	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
979982000316	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
979982000317	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
979982000318	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
979982000319	Walker A motif; other site
979982000320	ATP binding site [chemical binding]; other site
979982000321	Walker B motif; other site
979982000322	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
979982000323	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
979982000324	G1 box; other site
979982000325	GTP/Mg2+ binding site [chemical binding]; other site
979982000326	Switch I region; other site
979982000327	G2 box; other site
979982000328	G3 box; other site
979982000329	Switch II region; other site
979982000330	G4 box; other site
979982000331	G5 box; other site
979982000332	Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198
979982000333	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
979982000334	ATP binding site [chemical binding]; other site
979982000335	putative Mg++ binding site [ion binding]; other site
979982000336	helicase superfamily c-terminal domain; Region: HELICc; smart00490
979982000337	ATP-binding site [chemical binding]; other site
979982000338	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
979982000339	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
979982000340	putative active site [active]
979982000341	substrate binding site [chemical binding]; other site
979982000342	putative cosubstrate binding site; other site
979982000343	catalytic site [active]
979982000344	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
979982000345	substrate binding site [chemical binding]; other site
979982000346	16S rRNA methyltransferase B; Provisional; Region: PRK14902
979982000347	NusB family; Region: NusB; pfam01029
979982000348	putative RNA binding site [nucleotide binding]; other site
979982000349	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
979982000350	S-adenosylmethionine binding site [chemical binding]; other site
979982000351	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
979982000352	active site
979982000353	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
979982000354	Catalytic domain of Protein Kinases; Region: PKc; cd00180
979982000355	active site
979982000356	ATP binding site [chemical binding]; other site
979982000357	substrate binding site [chemical binding]; other site
979982000358	activation loop (A-loop); other site
979982000359	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
979982000360	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
979982000361	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
979982000362	GTPase RsgA; Reviewed; Region: PRK00098
979982000363	S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466
979982000364	RNA binding site [nucleotide binding]; other site
979982000365	homodimer interface [polypeptide binding]; other site
979982000366	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
979982000367	GTPase/Zn-binding domain interface [polypeptide binding]; other site
979982000368	GTP/Mg2+ binding site [chemical binding]; other site
979982000369	G4 box; other site
979982000370	G5 box; other site
979982000371	G1 box; other site
979982000372	Switch I region; other site
979982000373	G2 box; other site
979982000374	G3 box; other site
979982000375	Switch II region; other site
979982000376	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
979982000377	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
979982000378	substrate binding site [chemical binding]; other site
979982000379	hexamer interface [polypeptide binding]; other site
979982000380	metal binding site [ion binding]; metal-binding site
979982000381	Thiamine pyrophosphokinase; Region: TPK; cd07995
979982000382	thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378
979982000383	active site
979982000384	dimerization interface [polypeptide binding]; other site
979982000385	thiamine binding site [chemical binding]; other site
979982000386	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
979982000387	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
979982000388	catalytic residues [active]
979982000389	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
979982000390	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302
979982000391	DAK2 domain fusion protein YloV; Region: YloV; TIGR03599
979982000392	DAK2 domain; Region: Dak2; pfam02734
979982000393	Protein of unknown function (DUF4044); Region: DUF4044; pfam13253
979982000394	cell division protein MraZ; Reviewed; Region: PRK00326
979982000395	MraZ protein; Region: MraZ; pfam02381
979982000396	MraZ protein; Region: MraZ; pfam02381
979982000397	MraW methylase family; Region: Methyltransf_5; pfam01795
979982000398	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
979982000399	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
979982000400	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
979982000401	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
979982000402	PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576
979982000403	PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575
979982000404	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
979982000405	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
979982000406	Mg++ binding site [ion binding]; other site
979982000407	putative catalytic motif [active]
979982000408	putative substrate binding site [chemical binding]; other site
979982000409	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472
979982000410	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
979982000411	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
979982000412	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
979982000413	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
979982000414	active site
979982000415	homodimer interface [polypeptide binding]; other site
979982000416	Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589
979982000417	Cell division protein FtsQ; Region: FtsQ; pfam03799
979982000418	Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849
979982000419	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
979982000420	nucleotide binding site [chemical binding]; other site
979982000421	SHS2 domain inserted in FTSA; Region: SHS2_FTSA; pfam02491
979982000422	Cell division protein FtsA; Region: FtsA; pfam14450
979982000423	cell division protein FtsZ; Validated; Region: PRK09330
979982000424	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
979982000425	nucleotide binding site [chemical binding]; other site
979982000426	SulA interaction site; other site
979982000427	Protein of unknown function (DUF552); Region: DUF552; pfam04472
979982000428	YGGT family; Region: YGGT; pfam02325
979982000429	Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302
979982000430	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
979982000431	RNA binding surface [nucleotide binding]; other site
979982000432	DivIVA protein; Region: DivIVA; pfam05103
979982000433	DivIVA domain; Region: DivI1A_domain; TIGR03544
979982000434	isoleucyl-tRNA synthetase; Provisional; Region: ileS; PRK13804
979982000435	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
979982000436	active site
979982000437	HIGH motif; other site
979982000438	nucleotide binding site [chemical binding]; other site
979982000439	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
979982000440	active site
979982000441	KMSKS motif; other site
979982000442	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
979982000443	tRNA binding surface [nucleotide binding]; other site
979982000444	anticodon binding site; other site
979982000445	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
979982000446	active site
979982000447	P-loop; other site
979982000448	phosphorylation site [posttranslational modification]
979982000449	Predicted membrane protein [Function unknown]; Region: COG4684
979982000450	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
979982000451	Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547
979982000452	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
979982000453	active site
979982000454	Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641
979982000455	Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303
979982000456	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
979982000457	Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347
979982000458	putative ligand binding site [chemical binding]; other site
979982000459	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
979982000460	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
979982000461	TM-ABC transporter signature motif; other site
979982000462	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
979982000463	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
979982000464	TM-ABC transporter signature motif; other site
979982000465	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
979982000466	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
979982000467	Walker A/P-loop; other site
979982000468	ATP binding site [chemical binding]; other site
979982000469	Q-loop/lid; other site
979982000470	ABC transporter signature motif; other site
979982000471	Walker B; other site
979982000472	D-loop; other site
979982000473	H-loop/switch region; other site
979982000474	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
979982000475	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
979982000476	Walker A/P-loop; other site
979982000477	ATP binding site [chemical binding]; other site
979982000478	Q-loop/lid; other site
979982000479	ABC transporter signature motif; other site
979982000480	Walker B; other site
979982000481	D-loop; other site
979982000482	H-loop/switch region; other site
979982000483	potential frameshift: common BLAST hit: gi|296110582|ref|YP_003620963.1| amino acid transport protein
979982000484	homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485
979982000485	Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574
979982000486	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
979982000487	FAD binding site [chemical binding]; other site
979982000488	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
979982000489	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
979982000490	dimer interface [polypeptide binding]; other site
979982000491	ABC-ATPase subunit interface; other site
979982000492	putative PBP binding loops; other site
979982000493	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
979982000494	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
979982000495	Walker A/P-loop; other site
979982000496	ATP binding site [chemical binding]; other site
979982000497	Q-loop/lid; other site
979982000498	ABC transporter signature motif; other site
979982000499	Walker B; other site
979982000500	D-loop; other site
979982000501	H-loop/switch region; other site
979982000502	NMT1/THI5 like; Region: NMT1; pfam09084
979982000503	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
979982000504	substrate binding pocket [chemical binding]; other site
979982000505	membrane-bound complex binding site; other site
979982000506	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222
979982000507	CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312
979982000508	THF binding site; other site
979982000509	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
979982000510	substrate binding site [chemical binding]; other site
979982000511	THF binding site; other site
979982000512	zinc-binding site [ion binding]; other site
979982000513	prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597
979982000514	Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015
979982000515	tetramer interface [polypeptide binding]; other site
979982000516	active site
979982000517	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
979982000518	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
979982000519	substrate binding pocket [chemical binding]; other site
979982000520	membrane-bound complex binding site; other site
979982000521	hinge residues; other site
979982000522	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
979982000523	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
979982000524	dimer interface [polypeptide binding]; other site
979982000525	conserved gate region; other site
979982000526	putative PBP binding loops; other site
979982000527	ABC-ATPase subunit interface; other site
979982000528	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
979982000529	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
979982000530	Walker A/P-loop; other site
979982000531	ATP binding site [chemical binding]; other site
979982000532	Q-loop/lid; other site
979982000533	ABC transporter signature motif; other site
979982000534	Walker B; other site
979982000535	D-loop; other site
979982000536	H-loop/switch region; other site
979982000537	MmgE/PrpD family; Region: MmgE_PrpD; cl00912
979982000538	Tubby C 2; Region: Tub_2; cl02043
979982000539	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
979982000540	ligand binding site [chemical binding]; other site
979982000541	active site
979982000542	UGI interface [polypeptide binding]; other site
979982000543	catalytic site [active]
979982000544	phosphotransacetylase; Reviewed; Region: eutD; PRK09653
979982000545	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
979982000546	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
979982000547	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
979982000548	Walker A/P-loop; other site
979982000549	ATP binding site [chemical binding]; other site
979982000550	Q-loop/lid; other site
979982000551	ABC transporter signature motif; other site
979982000552	Walker B; other site
979982000553	D-loop; other site
979982000554	H-loop/switch region; other site
979982000555	3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355
979982000556	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
979982000557	catalytic residue [active]
979982000558	Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_3; cd12174
979982000559	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
979982000560	putative ligand binding site [chemical binding]; other site
979982000561	putative NAD binding site [chemical binding]; other site
979982000562	C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901
979982000563	L-serine binding site [chemical binding]; other site
979982000564	ACT domain interface; other site
979982000565	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
979982000566	tetramer interfaces [polypeptide binding]; other site
979982000567	binuclear metal-binding site [ion binding]; other site
979982000568	hypothetical protein; Validated; Region: PRK00110
979982000569	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
979982000570	Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580
979982000571	amphipathic channel; other site
979982000572	Asn-Pro-Ala signature motifs; other site
979982000573	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
979982000574	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
979982000575	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
979982000576	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
979982000577	active site
979982000578	dimer interface [polypeptide binding]; other site
979982000579	motif 1; other site
979982000580	motif 2; other site
979982000581	motif 3; other site
979982000582	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
979982000583	anticodon binding site; other site
979982000584	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
979982000585	Protein of unknown function (DUF1361); Region: DUF1361; pfam07099
979982000586	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
979982000587	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
979982000588	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
979982000589	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
979982000590	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
979982000591	23S rRNA binding site [nucleotide binding]; other site
979982000592	L21 binding site [polypeptide binding]; other site
979982000593	L13 binding site [polypeptide binding]; other site
979982000594	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
979982000595	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
979982000596	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
979982000597	elongation factor Tu; Reviewed; Region: PRK00049
979982000598	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
979982000599	G1 box; other site
979982000600	GEF interaction site [polypeptide binding]; other site
979982000601	GTP/Mg2+ binding site [chemical binding]; other site
979982000602	Switch I region; other site
979982000603	G2 box; other site
979982000604	G3 box; other site
979982000605	Switch II region; other site
979982000606	G4 box; other site
979982000607	G5 box; other site
979982000608	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
979982000609	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
979982000610	Antibiotic Binding Site [chemical binding]; other site
979982000611	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
979982000612	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
979982000613	Walker A/P-loop; other site
979982000614	ATP binding site [chemical binding]; other site
979982000615	Q-loop/lid; other site
979982000616	ABC transporter signature motif; other site
979982000617	Walker B; other site
979982000618	D-loop; other site
979982000619	H-loop/switch region; other site
979982000620	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
979982000621	tetramer (dimer of dimers) interface [polypeptide binding]; other site
979982000622	active site
979982000623	dimer interface [polypeptide binding]; other site
979982000624	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
979982000625	Ligand Binding Site [chemical binding]; other site
979982000626	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
979982000627	active site
979982000628	tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519
979982000629	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
979982000630	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
979982000631	active site
979982000632	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
979982000633	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
979982000634	HIGH motif; other site
979982000635	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
979982000636	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
979982000637	active site
979982000638	KMSKS motif; other site
979982000639	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
979982000640	tRNA binding surface [nucleotide binding]; other site
979982000641	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
979982000642	Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124
979982000643	Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704
979982000644	heat shock protein HtpX; Provisional; Region: PRK04897
979982000645	inosine 5-monophosphate dehydrogenase; Validated; Region: PRK06843
979982000646	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
979982000647	active site
979982000648	inosine 5-monophosphate dehydrogenase; Validated; Region: PRK06843
979982000649	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
979982000650	phosphate binding site [ion binding]; other site
979982000651	GMP synthase; Reviewed; Region: guaA; PRK00074
979982000652	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
979982000653	AMP/PPi binding site [chemical binding]; other site
979982000654	candidate oxyanion hole; other site
979982000655	catalytic triad [active]
979982000656	potential glutamine specificity residues [chemical binding]; other site
979982000657	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
979982000658	ATP Binding subdomain [chemical binding]; other site
979982000659	Dimerization subdomain; other site
979982000660	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
979982000661	non-specific DNA binding site [nucleotide binding]; other site
979982000662	salt bridge; other site
979982000663	sequence-specific DNA binding site [nucleotide binding]; other site
979982000664	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
979982000665	Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234
979982000666	Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744
979982000667	Transglycosylase; Region: Transgly; pfam00912
979982000668	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
979982000669	hypothetical protein; Provisional; Region: PRK13660
979982000670	cell division protein GpsB; Provisional; Region: PRK14127
979982000671	DivIVA domain; Region: DivI1A_domain; TIGR03544
979982000672	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
979982000673	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
979982000674	substrate binding pocket [chemical binding]; other site
979982000675	membrane-bound complex binding site; other site
979982000676	hinge residues; other site
979982000677	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
979982000678	dimer interface [polypeptide binding]; other site
979982000679	conserved gate region; other site
979982000680	ABC-ATPase subunit interface; other site
979982000681	AIR carboxylase; Region: AIRC; pfam00731
979982000682	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
979982000683	ATP-grasp domain; Region: ATP-grasp; pfam02222
979982000684	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
979982000685	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
979982000686	ATP binding site [chemical binding]; other site
979982000687	active site
979982000688	substrate binding site [chemical binding]; other site
979982000689	Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700
979982000690	phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619
979982000691	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
979982000692	putative active site [active]
979982000693	catalytic triad [active]
979982000694	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
979982000695	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
979982000696	dimerization interface [polypeptide binding]; other site
979982000697	ATP binding site [chemical binding]; other site
979982000698	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
979982000699	dimerization interface [polypeptide binding]; other site
979982000700	ATP binding site [chemical binding]; other site
979982000701	amidophosphoribosyltransferase; Provisional; Region: PRK07272
979982000702	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
979982000703	active site
979982000704	tetramer interface [polypeptide binding]; other site
979982000705	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
979982000706	active site
979982000707	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
979982000708	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
979982000709	dimerization interface [polypeptide binding]; other site
979982000710	putative ATP binding site [chemical binding]; other site
979982000711	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
979982000712	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
979982000713	active site
979982000714	substrate binding site [chemical binding]; other site
979982000715	cosubstrate binding site; other site
979982000716	catalytic site [active]
979982000717	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
979982000718	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
979982000719	purine monophosphate binding site [chemical binding]; other site
979982000720	dimer interface [polypeptide binding]; other site
979982000721	putative catalytic residues [active]
979982000722	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
979982000723	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
979982000724	MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427
979982000725	putative active site [active]
979982000726	nucleotide binding site [chemical binding]; other site
979982000727	nudix motif; other site
979982000728	putative metal binding site [ion binding]; other site
979982000729	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
979982000730	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
979982000731	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
979982000732	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
979982000733	formate--tetrahydrofolate ligase; Provisional; Region: PRK13505
979982000734	Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477
979982000735	Potassium binding sites [ion binding]; other site
979982000736	Cesium cation binding sites [ion binding]; other site
979982000737	S-formylglutathione hydrolase; Region: PLN02442
979982000738	Predicted esterase [General function prediction only]; Region: COG0627
979982000739	oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890
979982000740	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
979982000741	putative substrate translocation pore; other site
979982000742	adenylosuccinate lyase; Provisional; Region: PRK07492
979982000743	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
979982000744	tetramer interface [polypeptide binding]; other site
979982000745	active site
979982000746	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
979982000747	active site
979982000748	Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547
979982000749	isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437
979982000750	Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811
979982000751	homotetramer interface [polypeptide binding]; other site
979982000752	FMN binding site [chemical binding]; other site
979982000753	homodimer contacts [polypeptide binding]; other site
979982000754	putative active site [active]
979982000755	putative substrate binding site [chemical binding]; other site
979982000756	phosphomevalonate kinase, ERG8-type, Gram-positive branch; Region: Pmev_kin_Gr_pos; TIGR01220
979982000757	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
979982000758	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
979982000759	diphosphomevalonate decarboxylase; Region: PLN02407
979982000760	diphosphomevalonate decarboxylase; Region: mevDPdecarb; TIGR01240
979982000761	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
979982000762	Domain of unknown function DUF20; Region: UPF0118; pfam01594
979982000763	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
979982000764	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
979982000765	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
979982000766	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
979982000767	This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843
979982000768	Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001
979982000769	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
979982000770	Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295
979982000771	active site
979982000772	Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382
979982000773	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
979982000774	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
979982000775	glutaminase active site [active]
979982000776	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
979982000777	dimer interface [polypeptide binding]; other site
979982000778	active site
979982000779	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
979982000780	dimer interface [polypeptide binding]; other site
979982000781	active site
979982000782	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
979982000783	undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14830
979982000784	catalytic residue [active]
979982000785	putative FPP diphosphate  binding site; other site
979982000786	putative FPP binding hydrophobic cleft; other site
979982000787	dimer interface [polypeptide binding]; other site
979982000788	putative IPP diphosphate binding site; other site
979982000789	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
979982000790	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
979982000791	RIP metalloprotease RseP; Region: TIGR00054
979982000792	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
979982000793	active site
979982000794	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
979982000795	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
979982000796	protein binding site [polypeptide binding]; other site
979982000797	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
979982000798	putative substrate binding region [chemical binding]; other site
979982000799	prolyl-tRNA synthetase; Provisional; Region: PRK09194
979982000800	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
979982000801	dimer interface [polypeptide binding]; other site
979982000802	motif 1; other site
979982000803	active site
979982000804	motif 2; other site
979982000805	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
979982000806	putative deacylase active site [active]
979982000807	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
979982000808	active site
979982000809	motif 3; other site
979982000810	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
979982000811	anticodon binding site; other site
979982000812	DNA polymerase III PolC; Validated; Region: polC; PRK00448
979982000813	DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490
979982000814	polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484
979982000815	generic binding surface II; other site
979982000816	generic binding surface I; other site
979982000817	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
979982000818	active site
979982000819	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
979982000820	active site
979982000821	catalytic site [active]
979982000822	substrate binding site [chemical binding]; other site
979982000823	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435
979982000824	phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833
979982000825	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
979982000826	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
979982000827	substrate binding site [chemical binding]; other site
979982000828	dimer interface [polypeptide binding]; other site
979982000829	ATP binding site [chemical binding]; other site
979982000830	rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933
979982000831	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
979982000832	S-adenosylmethionine binding site [chemical binding]; other site
979982000833	pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636
979982000834	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
979982000835	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
979982000836	Putative amino acid metabolism; Region: DUF1831; pfam08866
979982000837	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
979982000838	catalytic core [active]
979982000839	helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448
979982000840	AAA domain; Region: AAA_30; pfam13604
979982000841	Family description; Region: UvrD_C_2; pfam13538
979982000842	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
979982000843	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
979982000844	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
979982000845	active site
979982000846	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
979982000847	active site
979982000848	catalytic triad [active]
979982000849	oxyanion hole [active]
979982000850	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
979982000851	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
979982000852	active site
979982000853	catalytic tetrad [active]
979982000854	Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cd00004
979982000855	active site
979982000856	catalytic site [active]
979982000857	mevalonate kinase; Region: mevalon_kin; TIGR00549
979982000858	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
979982000859	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
979982000860	active site
979982000861	catalytic site [active]
979982000862	substrate binding site [chemical binding]; other site
979982000863	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353
979982000864	aspartate aminotransferase; Provisional; Region: PRK05764
979982000865	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
979982000866	pyridoxal 5'-phosphate binding site [chemical binding]; other site
979982000867	homodimer interface [polypeptide binding]; other site
979982000868	catalytic residue [active]
979982000869	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
979982000870	AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs.  This domain is a...; Region: AsnRS_cyto_like_N; cd04323
979982000871	putative dimer interface [polypeptide binding]; other site
979982000872	putative anticodon binding site; other site
979982000873	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
979982000874	homodimer interface [polypeptide binding]; other site
979982000875	motif 1; other site
979982000876	motif 2; other site
979982000877	active site
979982000878	motif 3; other site
979982000879	Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935
979982000880	Replication initiation and membrane attachment; Region: DnaB_2; pfam07261
979982000881	Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116
979982000882	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
979982000883	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
979982000884	Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523
979982000885	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
979982000886	Nitroreductase-like family 4.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140
979982000887	dimer interface [polypeptide binding]; other site
979982000888	FMN binding site [chemical binding]; other site
979982000889	Transcriptional regulators [Transcription]; Region: PurR; COG1609
979982000890	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
979982000891	DNA binding site [nucleotide binding]
979982000892	domain linker motif; other site
979982000893	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
979982000894	dimerization interface [polypeptide binding]; other site
979982000895	ligand binding site [chemical binding]; other site
979982000896	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
979982000897	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
979982000898	Ca binding site [ion binding]; other site
979982000899	active site
979982000900	catalytic site [active]
979982000901	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
979982000902	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
979982000903	Major Facilitator Superfamily; Region: MFS_1; pfam07690
979982000904	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
979982000905	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
979982000906	Ca binding site [ion binding]; other site
979982000907	active site
979982000908	catalytic site [active]
979982000909	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
979982000910	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
979982000911	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
979982000912	dimer interface [polypeptide binding]; other site
979982000913	motif 1; other site
979982000914	active site
979982000915	motif 2; other site
979982000916	motif 3; other site
979982000917	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
979982000918	anticodon binding site; other site
979982000919	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
979982000920	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
979982000921	dimer interface [polypeptide binding]; other site
979982000922	anticodon binding site; other site
979982000923	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
979982000924	motif 1; other site
979982000925	dimer interface [polypeptide binding]; other site
979982000926	active site
979982000927	motif 2; other site
979982000928	GAD domain; Region: GAD; pfam02938
979982000929	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
979982000930	active site
979982000931	motif 3; other site
979982000932	Uncharacterized conserved protein [Function unknown]; Region: COG1284
979982000933	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
979982000934	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
979982000935	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
979982000936	Purine catabolism regulatory protein-like family; Region: PucR; pfam07905
979982000937	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
979982000938	Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317
979982000939	Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460
979982000940	active site
979982000941	Zn binding site [ion binding]; other site
979982000942	UDP-N-acetylmuramoylalanyl-D-glutamate--L-lysine ligase; Provisional; Region: PRK14022
979982000943	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
979982000944	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
979982000945	HicB family; Region: HicB; pfam05534
979982000946	Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356
979982000947	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
979982000948	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
979982000949	Tubby C 2; Region: Tub_2; cl02043
979982000950	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
979982000951	Flavoprotein; Region: Flavoprotein; pfam02441
979982000952	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
979982000953	arginyl-tRNA synthetase; Reviewed; Region: PRK12451
979982000954	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
979982000955	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
979982000956	active site
979982000957	HIGH motif; other site
979982000958	KMSK motif region; other site
979982000959	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
979982000960	tRNA binding surface [nucleotide binding]; other site
979982000961	anticodon binding site; other site
979982000962	Arginine repressor [Transcription]; Region: ArgR; COG1438
979982000963	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
979982000964	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
979982000965	Transglycosylase; Region: Transgly; pfam00912
979982000966	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
979982000967	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
979982000968	Protein of unknown function (DUF964); Region: DUF964; cl01483
979982000969	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
979982000970	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
979982000971	Catalytic site [active]
979982000972	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
979982000973	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
979982000974	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
979982000975	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
979982000976	dihydroorotase; Validated; Region: pyrC; PRK09357
979982000977	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
979982000978	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
979982000979	active site
979982000980	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
979982000981	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
979982000982	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
979982000983	catalytic site [active]
979982000984	subunit interface [polypeptide binding]; other site
979982000985	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
979982000986	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
979982000987	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
979982000988	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
979982000989	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
979982000990	ATP-grasp domain; Region: ATP-grasp_4; cl17255
979982000991	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
979982000992	IMP binding site; other site
979982000993	dimer interface [polypeptide binding]; other site
979982000994	interdomain contacts; other site
979982000995	partial ornithine binding site; other site
979982000996	dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037
979982000997	Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740
979982000998	heterodimer interface [polypeptide binding]; other site
979982000999	active site
979982001000	FMN binding site [chemical binding]; other site
979982001001	homodimer interface [polypeptide binding]; other site
979982001002	substrate binding site [chemical binding]; other site
979982001003	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
979982001004	active site
979982001005	dimer interface [polypeptide binding]; other site
979982001006	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
979982001007	active site
979982001008	LexA repressor; Validated; Region: PRK00215
979982001009	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
979982001010	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
979982001011	Catalytic site [active]
979982001012	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
979982001013	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
979982001014	putative acyl-acceptor binding pocket; other site
979982001015	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
979982001016	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
979982001017	S-adenosylmethionine binding site [chemical binding]; other site
979982001018	The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456
979982001019	GIY-YIG motif/motif A; other site
979982001020	putative active site [active]
979982001021	putative metal binding site [ion binding]; other site
979982001022	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
979982001023	rRNA interaction site [nucleotide binding]; other site
979982001024	S8 interaction site; other site
979982001025	putative laminin-1 binding site; other site
979982001026	potential frameshift: common BLAST hit: gi|296110371|ref|YP_003620752.1| elongation factor Ts
979982001027	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
979982001028	putative nucleotide binding site [chemical binding]; other site
979982001029	uridine monophosphate binding site [chemical binding]; other site
979982001030	homohexameric interface [polypeptide binding]; other site
979982001031	ribosome recycling factor; Reviewed; Region: frr; PRK00083
979982001032	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
979982001033	hinge region; other site
979982001034	Protein of unknown function (DUF805); Region: DUF805; pfam05656
979982001035	glycyl-tRNA synthetase subunit alpha; Validated; Region: glyQ; PRK09348
979982001036	motif 1; other site
979982001037	dimer interface [polypeptide binding]; other site
979982001038	active site
979982001039	motif 2; other site
979982001040	motif 3; other site
979982001041	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
979982001042	GTP-binding protein LepA; Provisional; Region: PRK05433
979982001043	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
979982001044	G1 box; other site
979982001045	putative GEF interaction site [polypeptide binding]; other site
979982001046	GTP/Mg2+ binding site [chemical binding]; other site
979982001047	Switch I region; other site
979982001048	G2 box; other site
979982001049	G3 box; other site
979982001050	Switch II region; other site
979982001051	G4 box; other site
979982001052	G5 box; other site
979982001053	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
979982001054	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
979982001055	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
979982001056	Arginate lyase and other MDR family members; Region: AL_MDR; cd08252
979982001057	zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817
979982001058	putative NAD(P) binding site [chemical binding]; other site
979982001059	dimer interface [polypeptide binding]; other site
979982001060	ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517
979982001061	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
979982001062	S-adenosylmethionine binding site [chemical binding]; other site
979982001063	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
979982001064	RNA methyltransferase, RsmE family; Region: TIGR00046
979982001065	ABC transporter ATP-binding protein; Provisional; Region: PRK15064
979982001066	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
979982001067	Walker A/P-loop; other site
979982001068	ATP binding site [chemical binding]; other site
979982001069	Q-loop/lid; other site
979982001070	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
979982001071	ABC transporter signature motif; other site
979982001072	Walker B; other site
979982001073	D-loop; other site
979982001074	ABC transporter; Region: ABC_tran_2; pfam12848
979982001075	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
979982001076	"initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827
979982001077	3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835
979982001078	dimer interface [polypeptide binding]; other site
979982001079	active site
979982001080	ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872
979982001081	Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025
979982001082	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
979982001083	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
979982001084	active site
979982001085	DNA binding site [nucleotide binding]
979982001086	Int/Topo IB signature motif; other site
979982001087	Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024
979982001088	active site
979982001089	catalytic residues [active]
979982001090	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
979982001091	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
979982001092	pyridoxal 5'-phosphate binding site [chemical binding]; other site
979982001093	catalytic residue [active]
979982001094	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
979982001095	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
979982001096	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
979982001097	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
979982001098	active site
979982001099	ribulose/triose binding site [chemical binding]; other site
979982001100	phosphate binding site [ion binding]; other site
979982001101	substrate (anthranilate) binding pocket [chemical binding]; other site
979982001102	product (indole) binding pocket [chemical binding]; other site
979982001103	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
979982001104	active site
979982001105	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
979982001106	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
979982001107	substrate binding site [chemical binding]; other site
979982001108	active site
979982001109	catalytic residues [active]
979982001110	heterodimer interface [polypeptide binding]; other site
979982001111	anthranilate synthase component I; Provisional; Region: PRK13570
979982001112	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
979982001113	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
979982001114	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
979982001115	Glutamine amidotransferase class-I; Region: GATase; pfam00117
979982001116	glutamine binding [chemical binding]; other site
979982001117	catalytic triad [active]
979982001118	Nicotinamide mononucleotide transporter; Region: NMN_transporter; cl01256
979982001119	Dihydroneopterin aldolase [Coenzyme metabolism]; Region: FolB; COG1539
979982001120	active site
979982001121	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
979982001122	catalytic center binding site [active]
979982001123	ATP binding site [chemical binding]; other site
979982001124	GTP cyclohydrolase I; Provisional; Region: PLN03044
979982001125	GTP cyclohydrolase I; Provisional; Region: folE; PRK09347
979982001126	active site
979982001127	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
979982001128	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
979982001129	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
979982001130	active site
979982001131	dimerization interface [polypeptide binding]; other site
979982001132	dihydropteroate synthase; Region: DHPS; TIGR01496
979982001133	Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  DHPS, a...; Region: Pterin_binding; cl00219
979982001134	substrate binding pocket [chemical binding]; other site
979982001135	dimer interface [polypeptide binding]; other site
979982001136	inhibitor binding site; inhibition site
979982001137	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
979982001138	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
979982001139	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
979982001140	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
979982001141	RNA binding site [nucleotide binding]; other site
979982001142	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
979982001143	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
979982001144	Coenzyme A binding pocket [chemical binding]; other site
979982001145	Uncharacterized conserved protein [Function unknown]; Region: COG1284
979982001146	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
979982001147	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
979982001148	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
979982001149	dimer interface [polypeptide binding]; other site
979982001150	substrate binding site [chemical binding]; other site
979982001151	ATP binding site [chemical binding]; other site
979982001152	ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; pfam07155
979982001153	anthranilate synthase component I; Reviewed; Region: PRK06404
979982001154	chorismate binding enzyme; Region: Chorismate_bind; cl10555
979982001155	Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037
979982001156	2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449
979982001157	dimer interface [polypeptide binding]; other site
979982001158	tetramer interface [polypeptide binding]; other site
979982001159	PYR/PP interface [polypeptide binding]; other site
979982001160	TPP binding site [chemical binding]; other site
979982001161	Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009
979982001162	TPP-binding site; other site
979982001163	2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695
979982001164	Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188
979982001165	o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928
979982001166	metal binding site [ion binding]; metal-binding site
979982001167	substrate binding pocket [chemical binding]; other site
979982001168	Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384
979982001169	Family of unknown function (DUF633); Region: DUF633; pfam04816
979982001170	Uncharacterized conserved protein [Function unknown]; Region: COG0327
979982001171	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
979982001172	peptidase T; Region: peptidase-T; TIGR01882
979982001173	M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892
979982001174	metal binding site [ion binding]; metal-binding site
979982001175	dimer interface [polypeptide binding]; other site
979982001176	Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506
979982001177	active site
979982001178	catalytic triad [active]
979982001179	oxyanion hole [active]
979982001180	Uncharacterized protein conserved in bacteria (DUF2140); Region: DUF2140; pfam09911
979982001181	hypothetical protein; Provisional; Region: PRK13672
979982001182	ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596
979982001183	Circularly permuted YlqF GTPase; Region: YlqF; cd01856
979982001184	GTP/Mg2+ binding site [chemical binding]; other site
979982001185	G4 box; other site
979982001186	G5 box; other site
979982001187	G1 box; other site
979982001188	Switch I region; other site
979982001189	G2 box; other site
979982001190	G3 box; other site
979982001191	Switch II region; other site
979982001192	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
979982001193	RNA/DNA hybrid binding site [nucleotide binding]; other site
979982001194	active site
979982001195	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
979982001196	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
979982001197	ligand binding site [chemical binding]; other site
979982001198	flexible hinge region; other site
979982001199	helix_turn_helix, cAMP Regulatory protein; Region: HTH_CRP; smart00419
979982001200	coenzyme A disulfide reductase; Reviewed; Region: PRK09564
979982001201	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
979982001202	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
979982001203	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
979982001204	Domain of unknown function DUF77; Region: DUF77; pfam01910
979982001205	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
979982001206	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
979982001207	S-adenosylmethionine binding site [chemical binding]; other site
979982001208	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
979982001209	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
979982001210	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
979982001211	MepB protein; Region: MepB; pfam08877
979982001212	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
979982001213	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
979982001214	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
979982001215	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
979982001216	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
979982001217	motif II; other site
979982001218	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
979982001219	Cupredoxin-like domain; Region: Cupredoxin_1; cl17234
979982001220	Predicted membrane protein [Function unknown]; Region: COG2261
979982001221	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
979982001222	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
979982001223	active site
979982001224	catalytic tetrad [active]
979982001225	D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892
979982001226	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
979982001227	putative active site [active]
979982001228	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
979982001229	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
979982001230	2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198
979982001231	oxidoreductase; Provisional; Region: PRK07985
979982001232	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
979982001233	NAD(P) binding site [chemical binding]; other site
979982001234	active site
979982001235	Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415
979982001236	DNA photolyase; Region: DNA_photolyase; pfam00875
979982001237	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
979982001238	acetoin reductases; Region: 23BDH; TIGR02415
979982001239	NAD(P) binding site [chemical binding]; other site
979982001240	active site
979982001241	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
979982001242	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
979982001243	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
979982001244	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
979982001245	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
979982001246	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
979982001247	FtsX-like permease family; Region: FtsX; pfam02687
979982001248	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
979982001249	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
979982001250	Walker A/P-loop; other site
979982001251	ATP binding site [chemical binding]; other site
979982001252	Q-loop/lid; other site
979982001253	ABC transporter signature motif; other site
979982001254	Walker B; other site
979982001255	D-loop; other site
979982001256	H-loop/switch region; other site
979982001257	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
979982001258	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
979982001259	H+ Antiporter protein; Region: 2A0121; TIGR00900
979982001260	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
979982001261	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
979982001262	putative active site [active]
979982001263	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
979982001264	PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830
979982001265	active site
979982001266	phosphorylation site [posttranslational modification]
979982001267	PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609
979982001268	PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613
979982001269	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025
979982001270	active site
979982001271	active pocket/dimerization site; other site
979982001272	phosphorylation site [posttranslational modification]
979982001273	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
979982001274	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
979982001275	Ca binding site [ion binding]; other site
979982001276	active site
979982001277	catalytic site [active]
979982001278	Protein of unknown function (DUF1349); Region: DUF1349; pfam07081
979982001279	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588
979982001280	Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659
979982001281	metal binding site [ion binding]; metal-binding site
979982001282	dimer interface [polypeptide binding]; other site
979982001283	Transcriptional regulators [Transcription]; Region: PurR; COG1609
979982001284	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
979982001285	DNA binding site [nucleotide binding]
979982001286	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
979982001287	galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270
979982001288	Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087
979982001289	Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744
979982001290	galactokinase; Provisional; Region: PRK05322
979982001291	Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509
979982001292	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
979982001293	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
979982001294	melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392
979982001295	sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792
979982001296	beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525
979982001297	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
979982001298	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
979982001299	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
979982001300	Beta galactosidase small chain; Region: Bgal_small_N; smart01038
979982001301	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
979982001302	active site
979982001303	catalytic residues [active]
979982001304	Predicted flavoprotein [General function prediction only]; Region: COG0431
979982001305	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
979982001306	Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979
979982001307	Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187
979982001308	dimer interface [polypeptide binding]; other site
979982001309	active site
979982001310	metal binding site [ion binding]; metal-binding site
979982001311	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
979982001312	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
979982001313	DNA binding residues [nucleotide binding]
979982001314	putative dimer interface [polypeptide binding]; other site
979982001315	short chain dehydrogenase; Provisional; Region: PRK06180
979982001316	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
979982001317	NADP binding site [chemical binding]; other site
979982001318	active site
979982001319	steroid binding site; other site
979982001320	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
979982001321	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
979982001322	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
979982001323	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
979982001324	A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194
979982001325	Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501
979982001326	Ligand binding site; other site
979982001327	metal-binding site
979982001328	acetylornithine deacetylase; Validated; Region: PRK08596
979982001329	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
979982001330	metal binding site [ion binding]; metal-binding site
979982001331	Putative transcription activator [Transcription]; Region: TenA; COG0819
979982001332	Transcriptional regulators [Transcription]; Region: PurR; COG1609
979982001333	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
979982001334	DNA binding site [nucleotide binding]
979982001335	domain linker motif; other site
979982001336	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
979982001337	2-deoxy-D-gluconate 3-dehydrogenase; Provisional; Region: PRK06935
979982001338	gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347
979982001339	NADP binding site [chemical binding]; other site
979982001340	homodimer interface [polypeptide binding]; other site
979982001341	active site
979982001342	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
979982001343	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
979982001344	LrgA family; Region: LrgA; cl00608
979982001345	LrgB-like family; Region: LrgB; cl00596
979982001346	pyruvate oxidase; Region: pyruv_oxi_spxB; TIGR02720
979982001347	Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039
979982001348	PYR/PP interface [polypeptide binding]; other site
979982001349	dimer interface [polypeptide binding]; other site
979982001350	tetramer interface [polypeptide binding]; other site
979982001351	TPP binding site [chemical binding]; other site
979982001352	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
979982001353	Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014
979982001354	TPP-binding site [chemical binding]; other site
979982001355	Protein of unknown function (DUF419); Region: DUF419; cl15265
979982001356	Predicted transcriptional regulators [Transcription]; Region: COG1733
979982001357	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
979982001358	Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137
979982001359	dimer interface [polypeptide binding]; other site
979982001360	FMN binding site [chemical binding]; other site
979982001361	maltose O-acetyltransferase; Provisional; Region: PRK10092
979982001362	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
979982001363	active site
979982001364	substrate binding site [chemical binding]; other site
979982001365	trimer interface [polypeptide binding]; other site
979982001366	CoA binding site [chemical binding]; other site
979982001367	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
979982001368	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
979982001369	EamA-like transporter family; Region: EamA; cl17759
979982001370	EamA-like transporter family; Region: EamA; pfam00892
979982001371	Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes.  All members...; Region: cytidine_deaminase-like; cl00269
979982001372	active site
979982001373	Zn binding site [ion binding]; other site
979982001374	Serine hydrolase; Region: Ser_hydrolase; cl17834
979982001375	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
979982001376	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
979982001377	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
979982001378	classical (c) SDRs; Region: SDR_c; cd05233
979982001379	NAD(P) binding site [chemical binding]; other site
979982001380	active site
979982001381	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
979982001382	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
979982001383	Small integral membrane protein (DUF2273); Region: DUF2273; cl11575
979982001384	Asp23 family; Region: Asp23; pfam03780
979982001385	MarR family; Region: MarR; pfam01047
979982001386	Acyl-CoA thioester hydrolase/BAAT N-terminal region; Region: Bile_Hydr_Trans; pfam04775
979982001387	ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837
979982001388	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
979982001389	Coenzyme A binding pocket [chemical binding]; other site
979982001390	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
979982001391	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
979982001392	Coenzyme A binding pocket [chemical binding]; other site
979982001393	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
979982001394	non-specific DNA binding site [nucleotide binding]; other site
979982001395	salt bridge; other site
979982001396	sequence-specific DNA binding site [nucleotide binding]; other site
979982001397	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
979982001398	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
979982001399	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
979982001400	Coenzyme A binding pocket [chemical binding]; other site
979982001401	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
979982001402	putative active site [active]
979982001403	Protein of unknown function (DUF1093); Region: DUF1093; pfam06486
979982001404	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
979982001405	Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349
979982001406	trimer interface [polypeptide binding]; other site
979982001407	active site
979982001408	substrate binding site [chemical binding]; other site
979982001409	CoA binding site [chemical binding]; other site
979982001410	Serine hydrolase; Region: Ser_hydrolase; cl17834
979982001411	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
979982001412	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
979982001413	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
979982001414	catalytic triad [active]
979982001415	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
979982001416	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
979982001417	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
979982001418	Coenzyme A binding pocket [chemical binding]; other site
979982001419	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
979982001420	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
979982001421	putative substrate translocation pore; other site
979982001422	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
979982001423	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
979982001424	Walker A/P-loop; other site
979982001425	ATP binding site [chemical binding]; other site
979982001426	ABC transporter signature motif; other site
979982001427	Walker B; other site
979982001428	D-loop; other site
979982001429	H-loop/switch region; other site
979982001430	ABC transporter; Region: ABC_tran_2; pfam12848
979982001431	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
979982001432	ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553
979982001433	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
979982001434	Coenzyme A binding pocket [chemical binding]; other site
979982001435	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
979982001436	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
979982001437	hypothetical protein; Validated; Region: PRK06769
979982001438	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
979982001439	active site
979982001440	motif I; other site
979982001441	motif II; other site
979982001442	CAAX protease self-immunity; Region: Abi; pfam02517
979982001443	Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062
979982001444	putative dimer interface [polypeptide binding]; other site
979982001445	catalytic triad [active]
979982001446	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
979982001447	conserved cys residue [active]
979982001448	DNA polymerase IV; Reviewed; Region: PRK03103
979982001449	umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700
979982001450	active site
979982001451	DNA binding site [nucleotide binding]
979982001452	Domain of unknown function (DUF4113); Region: DUF4113; pfam13438
979982001453	SAP domain; Region: SAP; pfam02037
979982001454	glucan-binding repeat; Region: glucan_65_rpt; TIGR04035
979982001455	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296
979982001456	putative active site [active]
979982001457	Enterocin A Immunity; Region: EntA_Immun; pfam08951
979982001458	Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225
979982001459	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
979982001460	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
979982001461	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
979982001462	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
979982001463	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
979982001464	motif II; other site
979982001465	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
979982001466	Transposase IS200 like; Region: Y1_Tnp; pfam01797
979982001467	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
979982001468	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
979982001469	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
979982001470	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
979982001471	dimer interface [polypeptide binding]; other site
979982001472	conserved gate region; other site
979982001473	putative PBP binding loops; other site
979982001474	ABC-ATPase subunit interface; other site
979982001475	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
979982001476	dimer interface [polypeptide binding]; other site
979982001477	conserved gate region; other site
979982001478	putative PBP binding loops; other site
979982001479	ABC-ATPase subunit interface; other site
979982001480	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
979982001481	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
979982001482	Walker A/P-loop; other site
979982001483	ATP binding site [chemical binding]; other site
979982001484	Q-loop/lid; other site
979982001485	ABC transporter signature motif; other site
979982001486	Walker B; other site
979982001487	D-loop; other site
979982001488	H-loop/switch region; other site
979982001489	TOBE domain; Region: TOBE_2; pfam08402
979982001490	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
979982001491	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
979982001492	active site
979982001493	catalytic tetrad [active]
979982001494	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
979982001495	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
979982001496	catalytic residues [active]
979982001497	dimer interface [polypeptide binding]; other site
979982001498	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
979982001499	(2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233
979982001500	putative NAD(P) binding site [chemical binding]; other site
979982001501	catalytic Zn binding site [ion binding]; other site
979982001502	Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033
979982001503	putative uracil binding site [chemical binding]; other site
979982001504	putative active site [active]
979982001505	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK06550
979982001506	classical (c) SDRs; Region: SDR_c; cd05233
979982001507	NAD(P) binding site [chemical binding]; other site
979982001508	active site
979982001509	QueT transporter; Region: QueT; pfam06177
979982001510	RNA polymerase sigma factor RpoD; Validated; Region: PRK09210
979982001511	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
979982001512	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
979982001513	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
979982001514	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
979982001515	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
979982001516	DNA binding residues [nucleotide binding]
979982001517	DNA primase; Validated; Region: dnaG; PRK05667
979982001518	CHC2 zinc finger; Region: zf-CHC2; pfam01807
979982001519	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
979982001520	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
979982001521	active site
979982001522	metal binding site [ion binding]; metal-binding site
979982001523	interdomain interaction site; other site
979982001524	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
979982001525	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
979982001526	conserved cys residue [active]
979982001527	2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390
979982001528	malate dehydrogenase; Provisional; Region: PRK13529
979982001529	Malic enzyme, N-terminal domain; Region: malic; pfam00390
979982001530	NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312
979982001531	NAD(P) binding site [chemical binding]; other site
979982001532	Transcriptional regulator [Transcription]; Region: LysR; COG0583
979982001533	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
979982001534	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
979982001535	dimerization interface [polypeptide binding]; other site
979982001536	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
979982001537	homopentamer interface [polypeptide binding]; other site
979982001538	active site
979982001539	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
979982001540	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
979982001541	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
979982001542	dimerization interface [polypeptide binding]; other site
979982001543	active site
979982001544	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
979982001545	Lumazine binding domain; Region: Lum_binding; pfam00677
979982001546	Lumazine binding domain; Region: Lum_binding; pfam00677
979982001547	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
979982001548	catalytic motif [active]
979982001549	Zn binding site [ion binding]; other site
979982001550	RibD C-terminal domain; Region: RibD_C; cl17279
979982001551	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
979982001552	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
979982001553	Ca binding site [ion binding]; other site
979982001554	active site
979982001555	catalytic site [active]
979982001556	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
979982001557	sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792
979982001558	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
979982001559	putative substrate translocation pore; other site
979982001560	hypothetical protein; Provisional; Region: yieM; PRK10997
979982001561	Transcriptional regulators [Transcription]; Region: PurR; COG1609
979982001562	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
979982001563	DNA binding site [nucleotide binding]
979982001564	domain linker motif; other site
979982001565	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
979982001566	potential frameshift: common BLAST hit: gi|296112122|ref|YP_003622504.1| glucosyltransferase-S
979982001567	transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716
979982001568	PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613
979982001569	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715
979982001570	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cl00021
979982001571	active site
979982001572	phosphorylation site [posttranslational modification]
979982001573	PTS system fructose IIA component; Region: EIIA-man; pfam03610
979982001574	active pocket/dimerization site; other site
979982001575	active site
979982001576	phosphorylation site [posttranslational modification]
979982001577	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
979982001578	DNA protecting protein DprA; Region: dprA; TIGR00732
979982001579	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
979982001580	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
979982001581	Walker A/P-loop; other site
979982001582	ATP binding site [chemical binding]; other site
979982001583	Q-loop/lid; other site
979982001584	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
979982001585	ABC transporter signature motif; other site
979982001586	Walker B; other site
979982001587	D-loop; other site
979982001588	ABC transporter; Region: ABC_tran_2; pfam12848
979982001589	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
979982001590	dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037
979982001591	Dihydroorotate dehydrogenase (DHOD) class 1A FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1A_like; cd04741
979982001592	active site
979982001593	FMN binding site [chemical binding]; other site
979982001594	substrate binding site [chemical binding]; other site
979982001595	catalytic residues [active]
979982001596	homodimer interface [polypeptide binding]; other site
979982001597	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
979982001598	propionate/acetate kinase; Provisional; Region: PRK12379
979982001599	Bacterial SH3 domain; Region: SH3_3; pfam08239
979982001600	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
979982001601	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
979982001602	active site
979982001603	metal binding site [ion binding]; metal-binding site
979982001604	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
979982001605	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
979982001606	ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553
979982001607	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
979982001608	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
979982001609	dimer interface [polypeptide binding]; other site
979982001610	active site
979982001611	glycine-pyridoxal phosphate binding site [chemical binding]; other site
979982001612	folate binding site [chemical binding]; other site
979982001613	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
979982001614	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560
979982001615	pyridoxal 5'-phosphate binding site [chemical binding]; other site
979982001616	catalytic residue [active]
979982001617	homoserine dehydrogenase; Provisional; Region: PRK06349
979982001618	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
979982001619	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
979982001620	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
979982001621	homoserine kinase; Provisional; Region: PRK01212
979982001622	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
979982001623	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
979982001624	aspartate kinase; Reviewed; Region: PRK09034
979982001625	AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245
979982001626	putative catalytic residues [active]
979982001627	putative nucleotide binding site [chemical binding]; other site
979982001628	putative aspartate binding site [chemical binding]; other site
979982001629	ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911
979982001630	allosteric regulatory residue; other site
979982001631	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
979982001632	DNA repair protein RecO; Region: reco; TIGR00613
979982001633	Recombination protein O N terminal; Region: RecO_N; pfam11967
979982001634	Recombination protein O C terminal; Region: RecO_C; pfam02565
979982001635	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
979982001636	active site
979982001637	homotetramer interface [polypeptide binding]; other site
979982001638	homodimer interface [polypeptide binding]; other site
979982001639	GTPase Era; Reviewed; Region: era; PRK00089
979982001640	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
979982001641	G1 box; other site
979982001642	GTP/Mg2+ binding site [chemical binding]; other site
979982001643	Switch I region; other site
979982001644	G2 box; other site
979982001645	Switch II region; other site
979982001646	G3 box; other site
979982001647	G4 box; other site
979982001648	G5 box; other site
979982001649	KH domain; Region: KH_2; pfam07650
979982001650	Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219
979982001651	metal-binding heat shock protein; Provisional; Region: PRK00016
979982001652	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
979982001653	PhoH-like protein; Region: PhoH; pfam02562
979982001654	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
979982001655	Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469
979982001656	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
979982001657	domain interfaces; other site
979982001658	active site
979982001659	DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587
979982001660	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431
979982001661	active site
979982001662	PHP Thumb interface [polypeptide binding]; other site
979982001663	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
979982001664	generic binding surface II; other site
979982001665	generic binding surface I; other site
979982001666	Protein of unknown function (DUF2929); Region: DUF2929; pfam11151
979982001667	3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710
979982001668	Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502
979982001669	active site
979982001670	catalytic residue [active]
979982001671	dimer interface [polypeptide binding]; other site
979982001672	Prephenate dehydratase; Region: PDT; pfam00800
979982001673	Sulfatase; Region: Sulfatase; cl17466
979982001674	shikimate kinase; Reviewed; Region: aroK; PRK00131
979982001675	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
979982001676	ADP binding site [chemical binding]; other site
979982001677	magnesium binding site [ion binding]; other site
979982001678	putative shikimate binding site; other site
979982001679	Chorismate mutase type II; Region: CM_2; smart00830
979982001680	prephenate dehydrogenase; Validated; Region: PRK08507
979982001681	Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287
979982001682	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
979982001683	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
979982001684	hinge; other site
979982001685	active site
979982001686	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
979982001687	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
979982001688	Tetramer interface [polypeptide binding]; other site
979982001689	active site
979982001690	FMN-binding site [chemical binding]; other site
979982001691	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
979982001692	active site
979982001693	dimer interface [polypeptide binding]; other site
979982001694	metal binding site [ion binding]; metal-binding site
979982001695	3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673
979982001696	3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; cl17225
979982001697	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
979982001698	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
979982001699	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
979982001700	shikimate binding site; other site
979982001701	NAD(P) binding site [chemical binding]; other site
979982001702	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
979982001703	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
979982001704	TPP-binding site [chemical binding]; other site
979982001705	dimer interface [polypeptide binding]; other site
979982001706	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
979982001707	PYR/PP interface [polypeptide binding]; other site
979982001708	dimer interface [polypeptide binding]; other site
979982001709	TPP binding site [chemical binding]; other site
979982001710	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
979982001711	5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694
979982001712	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
979982001713	NH_3: A subgroup of nucleoside hydrolases. This group contains eukaryotic and bacterial proteins similar to nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes...; Region: nuc_hydro_3; cd02653
979982001714	active site
979982001715	EDD domain protein, DegV family; Region: DegV; TIGR00762
979982001716	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
979982001717	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
979982001718	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
979982001719	folate binding site [chemical binding]; other site
979982001720	NADP+ binding site [chemical binding]; other site
979982001721	tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299
979982001722	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
979982001723	active site
979982001724	NTP binding site [chemical binding]; other site
979982001725	metal binding triad [ion binding]; metal-binding site
979982001726	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
979982001727	tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735
979982001728	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
979982001729	binding surface
979982001730	TPR motif; other site
979982001731	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
979982001732	binding surface
979982001733	TPR motif; other site
979982001734	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
979982001735	binding surface
979982001736	TPR motif; other site
979982001737	TPR repeat; Region: TPR_11; pfam13414
979982001738	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
979982001739	binding surface
979982001740	TPR motif; other site
979982001741	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
979982001742	IHF dimer interface [polypeptide binding]; other site
979982001743	IHF - DNA interface [nucleotide binding]; other site
979982001744	GTP-binding protein Der; Reviewed; Region: PRK00093
979982001745	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
979982001746	G1 box; other site
979982001747	GTP/Mg2+ binding site [chemical binding]; other site
979982001748	Switch I region; other site
979982001749	G2 box; other site
979982001750	Switch II region; other site
979982001751	G3 box; other site
979982001752	G4 box; other site
979982001753	G5 box; other site
979982001754	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
979982001755	G1 box; other site
979982001756	GTP/Mg2+ binding site [chemical binding]; other site
979982001757	Switch I region; other site
979982001758	G2 box; other site
979982001759	G3 box; other site
979982001760	Switch II region; other site
979982001761	G4 box; other site
979982001762	G5 box; other site
979982001763	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676
979982001764	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
979982001765	RNA binding site [nucleotide binding]; other site
979982001766	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
979982001767	RNA binding site [nucleotide binding]; other site
979982001768	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
979982001769	RNA binding site [nucleotide binding]; other site
979982001770	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692
979982001771	RNA binding site [nucleotide binding]; other site
979982001772	cytidylate kinase; Provisional; Region: cmk; PRK00023
979982001773	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
979982001774	CMP-binding site; other site
979982001775	The sites determining sugar specificity; other site
979982001776	Predicted membrane protein [Function unknown]; Region: COG3601
979982001777	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
979982001778	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
979982001779	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
979982001780	RNA binding surface [nucleotide binding]; other site
979982001781	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
979982001782	active site
979982001783	segregation and condensation protein B; Reviewed; Region: scpB; PRK00135
979982001784	segregation and condensation protein A; Reviewed; Region: scpA; PRK00104
979982001785	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
979982001786	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
979982001787	active site
979982001788	Int/Topo IB signature motif; other site
979982001789	Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996
979982001790	S1 domain; Region: S1_2; pfam13509
979982001791	Yqey-like protein; Region: YqeY; pfam09424
979982001792	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
979982001793	tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042
979982001794	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
979982001795	FMN binding site [chemical binding]; other site
979982001796	active site
979982001797	catalytic residues [active]
979982001798	substrate binding site [chemical binding]; other site
979982001799	folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499
979982001800	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
979982001801	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
979982001802	Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562
979982001803	putative active site [active]
979982001804	catalytic site [active]
979982001805	putative metal binding site [ion binding]; other site
979982001806	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
979982001807	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
979982001808	NAD binding site [chemical binding]; other site
979982001809	Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303
979982001810	Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641
979982001811	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
979982001812	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
979982001813	homodimer interface [polypeptide binding]; other site
979982001814	substrate-cofactor binding pocket; other site
979982001815	catalytic residue [active]
979982001816	Protein of unknown function (DUF1027); Region: DUF1027; cl09961
979982001817	Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845
979982001818	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
979982001819	active site
979982001820	metal binding site [ion binding]; metal-binding site
979982001821	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
979982001822	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
979982001823	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
979982001824	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
979982001825	active site
979982001826	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
979982001827	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
979982001828	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
979982001829	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
979982001830	CsbD-like; Region: CsbD; pfam05532
979982001831	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
979982001832	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
979982001833	tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121
979982001834	Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975
979982001835	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
979982001836	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
979982001837	Walker A/P-loop; other site
979982001838	ATP binding site [chemical binding]; other site
979982001839	Q-loop/lid; other site
979982001840	ABC transporter signature motif; other site
979982001841	Walker B; other site
979982001842	D-loop; other site
979982001843	H-loop/switch region; other site
979982001844	HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277
979982001845	HIT family signature motif; other site
979982001846	catalytic residue [active]
979982001847	peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405
979982001848	PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145
979982001849	3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480
979982001850	YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492
979982001851	generic binding surface II; other site
979982001852	generic binding surface I; other site
979982001853	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
979982001854	Zn2+ binding site [ion binding]; other site
979982001855	Mg2+ binding site [ion binding]; other site
979982001856	Uncharacterized conserved protein [Function unknown]; Region: COG4717
979982001857	Uncharacterized conserved protein [Function unknown]; Region: COG4717
979982001858	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
979982001859	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
979982001860	active site
979982001861	metal binding site [ion binding]; metal-binding site
979982001862	DNA binding site [nucleotide binding]
979982001863	Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282
979982001864	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
979982001865	active site
979982001866	catalytic triad [active]
979982001867	oxyanion hole [active]
979982001868	DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; cl17626
979982001869	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
979982001870	conserved cys residue [active]
979982001871	YCII-related domain; Region: YCII; cl00999
979982001872	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
979982001873	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
979982001874	G1 box; other site
979982001875	putative GEF interaction site [polypeptide binding]; other site
979982001876	GTP/Mg2+ binding site [chemical binding]; other site
979982001877	Switch I region; other site
979982001878	G2 box; other site
979982001879	G3 box; other site
979982001880	Switch II region; other site
979982001881	G4 box; other site
979982001882	G5 box; other site
979982001883	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
979982001884	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
979982001885	Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637
979982001886	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
979982001887	active site
979982001888	Uncharacterized protein family (UPF0223); Region: UPF0223; cl11484
979982001889	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
979982001890	active site
979982001891	catalytic residues [active]
979982001892	metal binding site [ion binding]; metal-binding site
979982001893	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
979982001894	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
979982001895	chaperone protein DnaJ; Provisional; Region: PRK14299
979982001896	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
979982001897	HSP70 interaction site [polypeptide binding]; other site
979982001898	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
979982001899	substrate binding site [polypeptide binding]; other site
979982001900	dimer interface [polypeptide binding]; other site
979982001901	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
979982001902	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
979982001903	nucleotide binding site [chemical binding]; other site
979982001904	NEF interaction site [polypeptide binding]; other site
979982001905	SBD interface [polypeptide binding]; other site
979982001906	GrpE; Region: GrpE; pfam01025
979982001907	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
979982001908	dimer interface [polypeptide binding]; other site
979982001909	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
979982001910	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
979982001911	Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444
979982001912	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
979982001913	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
979982001914	active site
979982001915	Riboflavin kinase; Region: Flavokinase; smart00904
979982001916	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK02484
979982001917	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
979982001918	RNA binding site [nucleotide binding]; other site
979982001919	active site
979982001920	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162
979982001921	HPr interaction site; other site
979982001922	glycerol kinase (GK) interaction site [polypeptide binding]; other site
979982001923	active site
979982001924	phosphorylation site [posttranslational modification]
979982001925	aromatic amino acid aminotransferase; Validated; Region: PRK07309
979982001926	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
979982001927	pyridoxal 5'-phosphate binding site [chemical binding]; other site
979982001928	homodimer interface [polypeptide binding]; other site
979982001929	catalytic residue [active]
979982001930	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
979982001931	translation initiation factor IF-2; Region: IF-2; TIGR00487
979982001932	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
979982001933	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
979982001934	G1 box; other site
979982001935	putative GEF interaction site [polypeptide binding]; other site
979982001936	GTP/Mg2+ binding site [chemical binding]; other site
979982001937	Switch I region; other site
979982001938	G2 box; other site
979982001939	G3 box; other site
979982001940	Switch II region; other site
979982001941	G4 box; other site
979982001942	G5 box; other site
979982001943	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
979982001944	Translation-initiation factor 2; Region: IF-2; pfam11987
979982001945	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
979982001946	Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600
979982001947	Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279
979982001948	putative RNA binding cleft [nucleotide binding]; other site
979982001949	transcription elongation factor NusA; Provisional; Region: nusA; PRK12327
979982001950	NusA N-terminal domain; Region: NusA_N; pfam08529
979982001951	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
979982001952	RNA binding site [nucleotide binding]; other site
979982001953	homodimer interface [polypeptide binding]; other site
979982001954	NusA-like KH domain; Region: KH_5; pfam13184
979982001955	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
979982001956	G-X-X-G motif; other site
979982001957	ribosome maturation protein RimP; Reviewed; Region: PRK00092
979982001958	Sm and related proteins; Region: Sm_like; cl00259
979982001959	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
979982001960	putative oligomer interface [polypeptide binding]; other site
979982001961	putative RNA binding site [nucleotide binding]; other site
979982001962	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
979982001963	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
979982001964	putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427
979982001965	DHH family; Region: DHH; pfam01368
979982001966	DHHA2 domain; Region: DHHA2; pfam02833
979982001967	DNA topoisomerase IV subunit A; Validated; Region: PRK05561
979982001968	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
979982001969	CAP-like domain; other site
979982001970	active site
979982001971	primary dimer interface [polypeptide binding]; other site
979982001972	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
979982001973	DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559
979982001974	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
979982001975	ATP binding site [chemical binding]; other site
979982001976	Mg2+ binding site [ion binding]; other site
979982001977	G-X-G motif; other site
979982001978	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
979982001979	anchoring element; other site
979982001980	dimer interface [polypeptide binding]; other site
979982001981	ATP binding site [chemical binding]; other site
979982001982	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
979982001983	active site
979982001984	putative metal-binding site [ion binding]; other site
979982001985	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
979982001986	Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410
979982001987	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
979982001988	putative active site [active]
979982001989	dimerization interface [polypeptide binding]; other site
979982001990	putative tRNAtyr binding site [nucleotide binding]; other site
979982001991	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
979982001992	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
979982001993	Zn2+ binding site [ion binding]; other site
979982001994	Mg2+ binding site [ion binding]; other site
979982001995	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
979982001996	synthetase active site [active]
979982001997	NTP binding site [chemical binding]; other site
979982001998	metal binding site [ion binding]; metal-binding site
979982001999	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
979982002000	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
979982002001	drug efflux system protein MdtG; Provisional; Region: PRK09874
979982002002	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
979982002003	putative substrate translocation pore; other site
979982002004	Carbamoylphosphate synthase large subunit (split gene in MJ) [Amino acid transport and metabolism / Nucleotide transport and metabolism]; Region: CarB; COG0458
979982002005	ATP-grasp domain; Region: ATP-grasp_4; cl17255
979982002006	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
979982002007	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; smart01096
979982002008	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12838
979982002009	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988
979982002010	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
979982002011	catalytic site [active]
979982002012	subunit interface [polypeptide binding]; other site
979982002013	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
979982002014	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
979982002015	active site
979982002016	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
979982002017	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
979982002018	RNA binding surface [nucleotide binding]; other site
979982002019	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
979982002020	active site
979982002021	RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279
979982002022	RNA/DNA hybrid binding site [nucleotide binding]; other site
979982002023	active site
979982002024	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
979982002025	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
979982002026	nucleotide binding site [chemical binding]; other site
979982002027	sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322
979982002028	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
979982002029	substrate binding [chemical binding]; other site
979982002030	active site
979982002031	PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996
979982002032	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
979982002033	active site turn [active]
979982002034	phosphorylation site [posttranslational modification]
979982002035	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
979982002036	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
979982002037	HPr interaction site; other site
979982002038	glycerol kinase (GK) interaction site [polypeptide binding]; other site
979982002039	active site
979982002040	phosphorylation site [posttranslational modification]
979982002041	Transcriptional regulators [Transcription]; Region: PurR; COG1609
979982002042	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
979982002043	DNA binding site [nucleotide binding]
979982002044	domain linker motif; other site
979982002045	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
979982002046	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
979982002047	active site 1 [active]
979982002048	dimer interface [polypeptide binding]; other site
979982002049	hexamer interface [polypeptide binding]; other site
979982002050	active site 2 [active]
979982002051	Uncharacterized conserved protein [Function unknown]; Region: COG1284
979982002052	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
979982002053	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
979982002054	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
979982002055	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
979982002056	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
979982002057	Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105
979982002058	DNA binding residues [nucleotide binding]
979982002059	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
979982002060	putative dimer interface [polypeptide binding]; other site
979982002061	DNA polymerase I; Provisional; Region: PRK05755
979982002062	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
979982002063	active site
979982002064	metal binding site 1 [ion binding]; metal-binding site
979982002065	putative 5' ssDNA interaction site; other site
979982002066	metal binding site 3; metal-binding site
979982002067	metal binding site 2 [ion binding]; metal-binding site
979982002068	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
979982002069	putative DNA binding site [nucleotide binding]; other site
979982002070	putative metal binding site [ion binding]; other site
979982002071	inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140
979982002072	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
979982002073	active site
979982002074	DNA binding site [nucleotide binding]
979982002075	catalytic site [active]
979982002076	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
979982002077	Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432
979982002078	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
979982002079	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
979982002080	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
979982002081	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
979982002082	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
979982002083	putative tRNA-binding site [nucleotide binding]; other site
979982002084	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584
979982002085	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704
979982002086	nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052
979982002087	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
979982002088	dimer interface [polypeptide binding]; other site
979982002089	ADP-ribose binding site [chemical binding]; other site
979982002090	active site
979982002091	nudix motif; other site
979982002092	metal binding site [ion binding]; metal-binding site
979982002093	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
979982002094	DNA-binding site [nucleotide binding]; DNA binding site
979982002095	RNA-binding motif; other site
979982002096	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
979982002097	Sulfate transporter family; Region: Sulfate_transp; pfam00916
979982002098	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
979982002099	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_b; cd04185
979982002100	Probable Catalytic site; other site
979982002101	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
979982002102	Cytidylyltransferase; Region: CTP_transf_2; pfam01467
979982002103	active site
979982002104	nucleotide binding site [chemical binding]; other site
979982002105	HIGH motif; other site
979982002106	KMSKS motif; other site
979982002107	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
979982002108	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
979982002109	Ligand binding site; other site
979982002110	Putative Catalytic site; other site
979982002111	DXD motif; other site
979982002112	UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562
979982002113	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
979982002114	UDP-galactopyranose mutase; Region: GLF; pfam03275
979982002115	Domain of unknown function (DUF4422); Region: DUF4422; pfam14393
979982002116	Bacterial sugar transferase; Region: Bac_transf; pfam02397
979982002117	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
979982002118	active site
979982002119	ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744
979982002120	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
979982002121	nucleotide binding site [chemical binding]; other site
979982002122	Bacterial protein of unknown function (DUF910); Region: DUF910; pfam06014
979982002123	Rhomboid family; Region: Rhomboid; pfam01694
979982002124	helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785
979982002125	Part of AAA domain; Region: AAA_19; pfam13245
979982002126	Family description; Region: UvrD_C_2; pfam13538
979982002127	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
979982002128	helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773
979982002129	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
979982002130	hypothetical protein; Provisional; Region: PRK13662
979982002131	RecX family; Region: RecX; cl00936
979982002132	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
979982002133	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
979982002134	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
979982002135	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
979982002136	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
979982002137	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
979982002138	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
979982002139	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
979982002140	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
979982002141	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
979982002142	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
979982002143	dihydrodipicolinate reductase; Provisional; Region: PRK00048
979982002144	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
979982002145	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
979982002146	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
979982002147	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
979982002148	dimer interface [polypeptide binding]; other site
979982002149	active site
979982002150	catalytic residue [active]
979982002151	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
979982002152	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
979982002153	metal binding site [ion binding]; metal-binding site
979982002154	Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503
979982002155	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532
979982002156	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
979982002157	putative trimer interface [polypeptide binding]; other site
979982002158	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
979982002159	putative CoA binding site [chemical binding]; other site
979982002160	putative trimer interface [polypeptide binding]; other site
979982002161	putative CoA binding site [chemical binding]; other site
979982002162	diaminopimelate decarboxylase; Region: lysA; TIGR01048
979982002163	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
979982002164	active site
979982002165	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
979982002166	substrate binding site [chemical binding]; other site
979982002167	catalytic residues [active]
979982002168	dimer interface [polypeptide binding]; other site
979982002169	putative nicotinate phosphoribosyltransferase; Provisional; Region: PRK09198
979982002170	Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an important role in NAD production by either allowing quinolinic acid (QA) , quinolinate phosphoribosyl transferase (QAPRTase), or nicotinic acid (NA), nicotinate...; Region: PRTase_typeII; cl17275
979982002171	active site
979982002172	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
979982002173	non-specific DNA binding site [nucleotide binding]; other site
979982002174	salt bridge; other site
979982002175	sequence-specific DNA binding site [nucleotide binding]; other site
979982002176	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
979982002177	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
979982002178	Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014
979982002179	Nicotinamide mononucleotide transporter; Region: NMN_transporter; cl01256
979982002180	50S ribosomal protein L32; Validated; Region: rpmF; PRK01110
979982002181	CutC family; Region: CutC; cl01218
979982002182	Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833
979982002183	Domain of unknown function (DUF814); Region: DUF814; pfam05670
979982002184	Methyltransferase domain; Region: Methyltransf_23; pfam13489
979982002185	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
979982002186	S-adenosylmethionine binding site [chemical binding]; other site
979982002187	Thymidylate synthase; Region: Thymidylat_synt; pfam00303
979982002188	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
979982002189	dimerization interface [polypeptide binding]; other site
979982002190	active site
979982002191	Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; cl17818
979982002192	XFP N-terminal domain; Region: XFP_N; pfam09364
979982002193	putative phosphoketolase; Provisional; Region: PRK05261
979982002194	XFP C-terminal domain; Region: XFP_C; pfam09363
979982002195	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
979982002196	putative substrate translocation pore; other site
979982002197	Major Facilitator Superfamily; Region: MFS_1; pfam07690
979982002198	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
979982002199	ornithine carbamoyltransferase; Validated; Region: PRK02102
979982002200	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
979982002201	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
979982002202	argininosuccinate lyase; Provisional; Region: PRK00855
979982002203	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
979982002204	active sites [active]
979982002205	tetramer interface [polypeptide binding]; other site
979982002206	argininosuccinate synthase; Provisional; Region: PRK13820
979982002207	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
979982002208	ANP binding site [chemical binding]; other site
979982002209	Substrate Binding Site II [chemical binding]; other site
979982002210	Substrate Binding Site I [chemical binding]; other site
979982002211	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581
979982002212	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
979982002213	MgtE intracellular N domain; Region: MgtE_N; pfam03448
979982002214	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
979982002215	Divalent cation transporter; Region: MgtE; pfam01769
979982002216	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
979982002217	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
979982002218	active site
979982002219	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885
979982002220	ATP-NAD kinase; Region: NAD_kinase; pfam01513
979982002221	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
979982002222	synthetase active site [active]
979982002223	NTP binding site [chemical binding]; other site
979982002224	metal binding site [ion binding]; metal-binding site
979982002225	Thioredoxin; Region: Thioredoxin_5; pfam13743
979982002226	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
979982002227	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
979982002228	active site
979982002229	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
979982002230	DHH family; Region: DHH; pfam01368
979982002231	Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; cl11538
979982002232	ribonuclease Z; Region: RNase_Z; TIGR02651
979982002233	methionine sulfoxide reductase A; Provisional; Region: PRK14054
979982002234	2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
979982002235	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
979982002236	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
979982002237	Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030
979982002238	Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797
979982002239	choice-of-anchor A domain; Region: choice_anch_A; TIGR04215
979982002240	Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030
979982002241	Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797
979982002242	WxL domain surface cell wall-binding; Region: WxL; pfam13731
979982002243	Uncharacterized conserved protein [Function unknown]; Region: COG2966
979982002244	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
979982002245	Protein of unknown function (DUF3815); Region: DUF3815; cl01118
979982002246	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
979982002247	Predicted transcriptional regulator [Transcription]; Region: COG2378
979982002248	HTH domain; Region: HTH_11; pfam08279
979982002249	WYL domain; Region: WYL; pfam13280
979982002250	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
979982002251	active site lid residues [active]
979982002252	substrate binding pocket [chemical binding]; other site
979982002253	catalytic residues [active]
979982002254	substrate-Mg2+ binding site; other site
979982002255	aspartate-rich region 1; other site
979982002256	aspartate-rich region 2; other site
979982002257	phytoene desaturase; Region: crtI_fam; TIGR02734
979982002258	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
979982002259	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
979982002260	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
979982002261	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
979982002262	HTH-like domain; Region: HTH_21; pfam13276
979982002263	Integrase core domain; Region: rve; pfam00665
979982002264	Integrase core domain; Region: rve_3; cl15866
979982002265	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
979982002266	Transposase; Region: HTH_Tnp_1; pfam01527
979982002267	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
979982002268	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
979982002269	NADP binding site [chemical binding]; other site
979982002270	active site
979982002271	putative substrate binding site [chemical binding]; other site
979982002272	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
979982002273	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
979982002274	NAD binding site [chemical binding]; other site
979982002275	substrate binding site [chemical binding]; other site
979982002276	homodimer interface [polypeptide binding]; other site
979982002277	active site
979982002278	dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898
979982002279	CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464
979982002280	Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
979982002281	Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
979982002282	CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464
979982002283	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
979982002284	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
979982002285	NADP binding site [chemical binding]; other site
979982002286	active site
979982002287	putative substrate binding site [chemical binding]; other site
979982002288	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
979982002289	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
979982002290	NAD binding site [chemical binding]; other site
979982002291	substrate binding site [chemical binding]; other site
979982002292	homodimer interface [polypeptide binding]; other site
979982002293	active site
979982002294	dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898
979982002295	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
979982002296	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
979982002297	substrate binding site; other site
979982002298	tetramer interface; other site
979982002299	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
979982002300	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
979982002301	active site
979982002302	Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
979982002303	CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464
979982002304	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
979982002305	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
979982002306	NAD(P) binding site [chemical binding]; other site
979982002307	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
979982002308	substrate binding site; other site
979982002309	dimer interface; other site
979982002310	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
979982002311	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
979982002312	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
979982002313	Walker A/P-loop; other site
979982002314	ATP binding site [chemical binding]; other site
979982002315	Q-loop/lid; other site
979982002316	ABC transporter signature motif; other site
979982002317	Walker B; other site
979982002318	D-loop; other site
979982002319	H-loop/switch region; other site
979982002320	Protein of unknown function (DUF3184); Region: DUF3184; pfam11380
979982002321	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
979982002322	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
979982002323	Bacterial sugar transferase; Region: Bac_transf; pfam02397
979982002324	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
979982002325	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
979982002326	substrate binding site; other site
979982002327	tetramer interface; other site
979982002328	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
979982002329	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
979982002330	active site
979982002331	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
979982002332	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
979982002333	RimM N-terminal domain; Region: RimM; pfam01782
979982002334	PRC-barrel domain; Region: PRC; pfam05239
979982002335	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
979982002336	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
979982002337	DNA binding site [nucleotide binding]
979982002338	active site
979982002339	PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765
979982002340	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
979982002341	active site
979982002342	phosphorylation site [posttranslational modification]
979982002343	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
979982002344	active site
979982002345	P-loop; other site
979982002346	phosphorylation site [posttranslational modification]
979982002347	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
979982002348	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
979982002349	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
979982002350	putative substrate binding site [chemical binding]; other site
979982002351	putative ATP binding site [chemical binding]; other site
979982002352	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
979982002353	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
979982002354	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
979982002355	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C); Region: NT5C; cl17836
979982002356	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
979982002357	Predicted membrane protein [Function unknown]; Region: COG3428
979982002358	Bacterial PH domain; Region: DUF304; pfam03703
979982002359	Bacterial PH domain; Region: DUF304; pfam03703
979982002360	Bacterial PH domain; Region: DUF304; pfam03703
979982002361	Uncharacterized conserved protein [Function unknown]; Region: COG3402
979982002362	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
979982002363	Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970
979982002364	Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673
979982002365	Thymidylate kinase; Region: Thymidylate_kin; pfam02223
979982002366	Substrate-binding site [chemical binding]; other site
979982002367	Substrate specificity [chemical binding]; other site
979982002368	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
979982002369	RuvA N terminal domain; Region: RuvA_N; pfam01330
979982002370	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
979982002371	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
979982002372	Aquifex aeolicus AQ1575 and related proteins, metallophosphatase domain; Region: MPP_AQ1575; cd07390
979982002373	putative active site [active]
979982002374	putative metal binding site [ion binding]; other site
979982002375	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
979982002376	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
979982002377	Walker A motif; other site
979982002378	ATP binding site [chemical binding]; other site
979982002379	Walker B motif; other site
979982002380	arginine finger; other site
979982002381	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
979982002382	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
979982002383	active site
979982002384	metal binding site [ion binding]; metal-binding site
979982002385	homotetramer interface [polypeptide binding]; other site
979982002386	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
979982002387	active site
979982002388	dimerization interface [polypeptide binding]; other site
979982002389	glutamate racemase; Provisional; Region: PRK00865
979982002390	Protein of unknown function (DUF2507); Region: DUF2507; pfam10702
979982002391	D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092
979982002392	DltD N-terminal region; Region: DltD_N; pfam04915
979982002393	DltD central region; Region: DltD_M; pfam04918
979982002394	DltD C-terminal region; Region: DltD_C; pfam04914
979982002395	D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087
979982002396	D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091
979982002397	D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813
979982002398	D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945
979982002399	acyl-activating enzyme (AAE) consensus motif; other site
979982002400	AMP binding site [chemical binding]; other site
979982002401	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
979982002402	Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028
979982002403	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
979982002404	DEAD-like helicases superfamily; Region: DEXDc; smart00487
979982002405	ATP binding site [chemical binding]; other site
979982002406	Mg++ binding site [ion binding]; other site
979982002407	motif III; other site
979982002408	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
979982002409	nucleotide binding region [chemical binding]; other site
979982002410	ATP-binding site [chemical binding]; other site
979982002411	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
979982002412	DHH family; Region: DHH; pfam01368
979982002413	DHHA1 domain; Region: DHHA1; pfam02272
979982002414	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
979982002415	active site
979982002416	DNA polymerase IV; Validated; Region: PRK02406
979982002417	DNA binding site [nucleotide binding]
979982002418	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
979982002419	phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150
979982002420	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
979982002421	active site
979982002422	substrate binding site [chemical binding]; other site
979982002423	metal binding site [ion binding]; metal-binding site
979982002424	Alpha amylase catalytic domain found in sucrose phosphorylase (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase; cd11355
979982002425	sucrose phosphorylase; Region: sucrose_gtfA; TIGR03852
979982002426	active site
979982002427	homodimer interface [polypeptide binding]; other site
979982002428	catalytic site [active]
979982002429	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
979982002430	Major Facilitator Superfamily; Region: MFS_1; pfam07690
979982002431	putative substrate translocation pore; other site
979982002432	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
979982002433	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
979982002434	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
979982002435	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
979982002436	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
979982002437	active site
979982002438	tetramer interface; other site
979982002439	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
979982002440	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
979982002441	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
979982002442	HPr kinase/phosphorylase; Provisional; Region: PRK05428
979982002443	HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603
979982002444	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918
979982002445	Hpr binding site; other site
979982002446	active site
979982002447	homohexamer subunit interaction site [polypeptide binding]; other site
979982002448	Membrane protein of unknown function; Region: DUF360; pfam04020
979982002449	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
979982002450	PhoU domain; Region: PhoU; pfam01895
979982002451	PhoU domain; Region: PhoU; pfam01895
979982002452	phosphate transporter ATP-binding protein; Provisional; Region: PRK14239
979982002453	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
979982002454	Walker A/P-loop; other site
979982002455	ATP binding site [chemical binding]; other site
979982002456	Q-loop/lid; other site
979982002457	ABC transporter signature motif; other site
979982002458	Walker B; other site
979982002459	D-loop; other site
979982002460	H-loop/switch region; other site
979982002461	phosphate transporter ATP-binding protein; Provisional; Region: PRK14237
979982002462	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
979982002463	Walker A/P-loop; other site
979982002464	ATP binding site [chemical binding]; other site
979982002465	Q-loop/lid; other site
979982002466	ABC transporter signature motif; other site
979982002467	Walker B; other site
979982002468	D-loop; other site
979982002469	H-loop/switch region; other site
979982002470	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
979982002471	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
979982002472	dimer interface [polypeptide binding]; other site
979982002473	conserved gate region; other site
979982002474	putative PBP binding loops; other site
979982002475	ABC-ATPase subunit interface; other site
979982002476	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
979982002477	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
979982002478	dimer interface [polypeptide binding]; other site
979982002479	conserved gate region; other site
979982002480	putative PBP binding loops; other site
979982002481	ABC-ATPase subunit interface; other site
979982002482	ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725
979982002483	PBP superfamily domain; Region: PBP_like_2; cl17296
979982002484	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
979982002485	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
979982002486	dimer interface [polypeptide binding]; other site
979982002487	phosphorylation site [posttranslational modification]
979982002488	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
979982002489	ATP binding site [chemical binding]; other site
979982002490	Mg2+ binding site [ion binding]; other site
979982002491	G-X-G motif; other site
979982002492	PBP superfamily domain; Region: PBP_like_2; cl17296
979982002493	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
979982002494	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
979982002495	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
979982002496	active site
979982002497	phosphorylation site [posttranslational modification]
979982002498	intermolecular recognition site; other site
979982002499	dimerization interface [polypeptide binding]; other site
979982002500	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
979982002501	DNA binding site [nucleotide binding]
979982002502	recombinase A; Provisional; Region: recA; PRK09354
979982002503	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
979982002504	hexamer interface [polypeptide binding]; other site
979982002505	Walker A motif; other site
979982002506	ATP binding site [chemical binding]; other site
979982002507	Walker B motif; other site
979982002508	CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Region: pgsA; TIGR00560
979982002509	Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426
979982002510	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
979982002511	non-specific DNA binding site [nucleotide binding]; other site
979982002512	salt bridge; other site
979982002513	sequence-specific DNA binding site [nucleotide binding]; other site
979982002514	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
979982002515	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
979982002516	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
979982002517	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
979982002518	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
979982002519	cardiolipin synthase; Region: bac_cardiolipin; TIGR04265
979982002520	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
979982002521	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
979982002522	putative active site [active]
979982002523	catalytic site [active]
979982002524	catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112
979982002525	putative active site [active]
979982002526	catalytic site [active]
979982002527	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
979982002528	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
979982002529	substrate binding pocket [chemical binding]; other site
979982002530	membrane-bound complex binding site; other site
979982002531	hinge residues; other site
979982002532	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
979982002533	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
979982002534	Walker A/P-loop; other site
979982002535	ATP binding site [chemical binding]; other site
979982002536	Q-loop/lid; other site
979982002537	ABC transporter signature motif; other site
979982002538	Walker B; other site
979982002539	D-loop; other site
979982002540	H-loop/switch region; other site
979982002541	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
979982002542	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
979982002543	dimer interface [polypeptide binding]; other site
979982002544	conserved gate region; other site
979982002545	putative PBP binding loops; other site
979982002546	ABC-ATPase subunit interface; other site
979982002547	rod shape-determining protein MreD; Region: MreD; cl01087
979982002548	rod shape-determining protein MreC; Provisional; Region: PRK13922
979982002549	rod shape-determining protein MreC; Region: MreC; pfam04085
979982002550	rod shape-determining protein MreB; Provisional; Region: PRK13927
979982002551	MreB and similar proteins; Region: MreB_like; cd10225
979982002552	nucleotide binding site [chemical binding]; other site
979982002553	Mg binding site [ion binding]; other site
979982002554	putative protofilament interaction site [polypeptide binding]; other site
979982002555	RodZ interaction site [polypeptide binding]; other site
979982002556	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
979982002557	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
979982002558	Walker A motif; other site
979982002559	ATP binding site [chemical binding]; other site
979982002560	Walker B motif; other site
979982002561	arginine finger; other site
979982002562	UvrB/uvrC motif; Region: UVR; pfam02151
979982002563	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
979982002564	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
979982002565	Walker A motif; other site
979982002566	ATP binding site [chemical binding]; other site
979982002567	Walker B motif; other site
979982002568	arginine finger; other site
979982002569	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
979982002570	AAA domain; Region: AAA_30; pfam13604
979982002571	Uncharacterized conserved protein (DUF2075); Region: DUF2075; pfam09848
979982002572	Uncharacterized conserved protein [Function unknown]; Region: COG3410
979982002573	Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998
979982002574	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
979982002575	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
979982002576	GDP-binding site [chemical binding]; other site
979982002577	ACT binding site; other site
979982002578	IMP binding site; other site
979982002579	histidinol-phosphate aminotransferase; Provisional; Region: PRK03158
979982002580	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
979982002581	pyridoxal 5'-phosphate binding site [chemical binding]; other site
979982002582	homodimer interface [polypeptide binding]; other site
979982002583	catalytic residue [active]
979982002584	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
979982002585	metal binding site [ion binding]; metal-binding site
979982002586	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
979982002587	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
979982002588	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
979982002589	substrate binding site [chemical binding]; other site
979982002590	glutamase interaction surface [polypeptide binding]; other site
979982002591	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
979982002592	phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007
979982002593	catalytic residues [active]
979982002594	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141
979982002595	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
979982002596	putative active site [active]
979982002597	oxyanion strand; other site
979982002598	catalytic triad [active]
979982002599	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
979982002600	putative active site pocket [active]
979982002601	4-fold oligomerization interface [polypeptide binding]; other site
979982002602	metal binding residues [ion binding]; metal-binding site
979982002603	3-fold/trimer interface [polypeptide binding]; other site
979982002604	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
979982002605	histidinol dehydrogenase; Region: hisD; TIGR00069
979982002606	NAD binding site [chemical binding]; other site
979982002607	dimerization interface [polypeptide binding]; other site
979982002608	product binding site; other site
979982002609	substrate binding site [chemical binding]; other site
979982002610	zinc binding site [ion binding]; other site
979982002611	catalytic residues [active]
979982002612	ATP phosphoribosyltransferase, regulatory subunit; Region: hisZ_biosyn_reg; TIGR00443
979982002613	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
979982002614	dimer interface [polypeptide binding]; other site
979982002615	motif 1; other site
979982002616	active site
979982002617	motif 2; other site
979982002618	motif 3; other site
979982002619	ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686
979982002620	ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040
979982002621	histidinol-phosphatase; Reviewed; Region: PRK08123
979982002622	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110
979982002623	active site
979982002624	dimer interface [polypeptide binding]; other site
979982002625	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
979982002626	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
979982002627	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
979982002628	methionine cluster; other site
979982002629	active site
979982002630	phosphorylation site [posttranslational modification]
979982002631	metal binding site [ion binding]; metal-binding site
979982002632	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
979982002633	HTH domain; Region: HTH_11; pfam08279
979982002634	Mga helix-turn-helix domain; Region: Mga; pfam05043
979982002635	PRD domain; Region: PRD; pfam00874
979982002636	PRD domain; Region: PRD; pfam00874
979982002637	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
979982002638	active site
979982002639	P-loop; other site
979982002640	phosphorylation site [posttranslational modification]
979982002641	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163
979982002642	active site
979982002643	phosphorylation site [posttranslational modification]
979982002644	cellobiose phosphotransferase system IIB component; Reviewed; Region: celB; PRK09590
979982002645	active site
979982002646	P-loop; other site
979982002647	phosphorylation site [posttranslational modification]
979982002648	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
979982002649	beta-galactosidase; Region: BGL; TIGR03356
979982002650	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
979982002651	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
979982002652	active site
979982002653	motif I; other site
979982002654	motif II; other site
979982002655	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
979982002656	signal recognition particle protein; Provisional; Region: PRK10867
979982002657	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
979982002658	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
979982002659	P loop; other site
979982002660	GTP binding site [chemical binding]; other site
979982002661	Signal peptide binding domain; Region: SRP_SPB; pfam02978
979982002662	putative DNA-binding protein; Validated; Region: PRK00118
979982002663	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
979982002664	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
979982002665	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
979982002666	P loop; other site
979982002667	GTP binding site [chemical binding]; other site
979982002668	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
979982002669	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
979982002670	Walker A/P-loop; other site
979982002671	ATP binding site [chemical binding]; other site
979982002672	Q-loop/lid; other site
979982002673	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968
979982002674	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
979982002675	ABC transporter signature motif; other site
979982002676	Walker B; other site
979982002677	D-loop; other site
979982002678	H-loop/switch region; other site
979982002679	ribonuclease III; Reviewed; Region: rnc; PRK00102
979982002680	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
979982002681	dimerization interface [polypeptide binding]; other site
979982002682	active site
979982002683	metal binding site [ion binding]; metal-binding site
979982002684	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
979982002685	dsRNA binding site [nucleotide binding]; other site
979982002686	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316
979982002687	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
979982002688	active site
979982002689	substrate binding site [chemical binding]; other site
979982002690	metal binding site [ion binding]; metal-binding site
979982002691	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856
979982002692	YbbR-like protein; Region: YbbR; pfam07949
979982002693	YbbR-like protein; Region: YbbR; pfam07949
979982002694	TIGR00159 family protein; Region: TIGR00159
979982002695	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
979982002696	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
979982002697	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
979982002698	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
979982002699	FAD binding domain; Region: FAD_binding_4; pfam01565
979982002700	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
979982002701	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
979982002702	active site
979982002703	multimer interface [polypeptide binding]; other site
979982002704	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807
979982002705	Protein of unknown function (DUF1456); Region: DUF1456; pfam07308
979982002706	Protein of unknown function (DUF1456); Region: DUF1456; pfam07308
979982002707	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
979982002708	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
979982002709	ATP binding site [chemical binding]; other site
979982002710	Mg2+ binding site [ion binding]; other site
979982002711	G-X-G motif; other site
979982002712	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
979982002713	ATP binding site [chemical binding]; other site
979982002714	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
979982002715	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
979982002716	MutS domain I; Region: MutS_I; pfam01624
979982002717	MutS domain II; Region: MutS_II; pfam05188
979982002718	MutS domain III; Region: MutS_III; pfam05192
979982002719	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
979982002720	Walker A/P-loop; other site
979982002721	ATP binding site [chemical binding]; other site
979982002722	Q-loop/lid; other site
979982002723	ABC transporter signature motif; other site
979982002724	Walker B; other site
979982002725	D-loop; other site
979982002726	H-loop/switch region; other site
979982002727	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
979982002728	RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966
979982002729	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
979982002730	generic binding surface II; other site
979982002731	ssDNA binding site; other site
979982002732	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
979982002733	ATP binding site [chemical binding]; other site
979982002734	putative Mg++ binding site [ion binding]; other site
979982002735	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
979982002736	nucleotide binding region [chemical binding]; other site
979982002737	ATP-binding site [chemical binding]; other site
979982002738	Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827
979982002739	active site
979982002740	catalytic site [active]
979982002741	Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827
979982002742	active site
979982002743	catalytic site [active]
979982002744	fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226
979982002745	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
979982002746	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
979982002747	metal ion-dependent adhesion site (MIDAS); other site
979982002748	Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222
979982002749	domain interaction interfaces [polypeptide binding]; other site
979982002750	Cna protein B-type domain; Region: Cna_B; pfam05738
979982002751	Cna protein B-type domain; Region: Cna_B; pfam05738
979982002752	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
979982002753	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
979982002754	catalytic residues [active]
979982002755	catalytic nucleophile [active]
979982002756	Presynaptic Site I dimer interface [polypeptide binding]; other site
979982002757	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
979982002758	Synaptic Flat tetramer interface [polypeptide binding]; other site
979982002759	Synaptic Site I dimer interface [polypeptide binding]; other site
979982002760	DNA binding site [nucleotide binding]
979982002761	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
979982002762	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100
979982002763	NAD(P) binding site [chemical binding]; other site
979982002764	catalytic residues [active]
979982002765	Protein of unknown function (DUF1440); Region: DUF1440; pfam07274
979982002766	VanW like protein; Region: VanW; pfam04294
979982002767	Protein of unknown function (DUF1706); Region: DUF1706; pfam08020
979982002768	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
979982002769	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
979982002770	non-specific DNA binding site [nucleotide binding]; other site
979982002771	salt bridge; other site
979982002772	sequence-specific DNA binding site [nucleotide binding]; other site
979982002773	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152
979982002774	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
979982002775	Walker A/P-loop; other site
979982002776	ATP binding site [chemical binding]; other site
979982002777	Q-loop/lid; other site
979982002778	ABC transporter signature motif; other site
979982002779	Walker B; other site
979982002780	D-loop; other site
979982002781	H-loop/switch region; other site
979982002782	Domain of unknown function (DUF4162); Region: DUF4162; pfam13732
979982002783	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
979982002784	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
979982002785	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
979982002786	active site
979982002787	catalytic tetrad [active]
979982002788	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
979982002789	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
979982002790	dimer interface [polypeptide binding]; other site
979982002791	conserved gate region; other site
979982002792	putative PBP binding loops; other site
979982002793	ABC-ATPase subunit interface; other site
979982002794	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113
979982002795	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
979982002796	ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175
979982002797	ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294
979982002798	Walker A/P-loop; other site
979982002799	ATP binding site [chemical binding]; other site
979982002800	Q-loop/lid; other site
979982002801	ABC transporter signature motif; other site
979982002802	Walker B; other site
979982002803	D-loop; other site
979982002804	H-loop/switch region; other site
979982002805	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
979982002806	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
979982002807	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
979982002808	DNA-binding site [nucleotide binding]; DNA binding site
979982002809	TrkA-C domain; Region: TrkA_C; pfam02080
979982002810	BioY family; Region: BioY; pfam02632
979982002811	Zinc finger domain containing protein (CHY type) [Function unknown]; Region: COG4357
979982002812	CHY zinc finger; Region: zf-CHY; pfam05495
979982002813	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
979982002814	5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190
979982002815	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
979982002816	homodimer interface [polypeptide binding]; other site
979982002817	NADP binding site [chemical binding]; other site
979982002818	substrate binding site [chemical binding]; other site
979982002819	Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286
979982002820	catalytic motif [active]
979982002821	Zn binding site [ion binding]; other site
979982002822	thymidylate synthase; Region: thym_sym; TIGR03284
979982002823	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
979982002824	dimerization interface [polypeptide binding]; other site
979982002825	active site
979982002826	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
979982002827	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
979982002828	Coenzyme A binding pocket [chemical binding]; other site
979982002829	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
979982002830	Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501
979982002831	active site
979982002832	accessory Sec system glycosyltransferase GtfB; Region: TIGR02919
979982002833	accessory Sec system glycosyltransferase GtfB; Region: TIGR02919
979982002834	accessory Sec system glycosylation protein GtfA; Region: TIGR02918
979982002835	This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding.  In...; Region: GT1_gtfA_like; cd04949
979982002836	beta-1,6-galactofuranosyltransferase; Provisional; Region: PRK09814
979982002837	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
979982002838	preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12898
979982002839	SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043
979982002840	SecA Wing and Scaffold domain; Region: SecA_SW; pfam07516
979982002841	HTH-like domain; Region: HTH_21; pfam13276
979982002842	Integrase core domain; Region: rve; pfam00665
979982002843	Integrase core domain; Region: rve_3; cl15866
979982002844	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
979982002845	Transposase; Region: HTH_Tnp_1; pfam01527
979982002846	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
979982002847	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_b; cd04185
979982002848	Probable Catalytic site; other site
979982002849	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
979982002850	active site
979982002851	Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
979982002852	CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464
979982002853	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
979982002854	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
979982002855	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
979982002856	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
979982002857	Walker A/P-loop; other site
979982002858	ATP binding site [chemical binding]; other site
979982002859	Q-loop/lid; other site
979982002860	ABC transporter signature motif; other site
979982002861	Walker B; other site
979982002862	D-loop; other site
979982002863	H-loop/switch region; other site
979982002864	anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804
979982002865	4Fe-4S single cluster domain; Region: Fer4_12; pfam13353
979982002866	anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263
979982002867	Class III ribonucleotide reductase; Region: RNR_III; cd01675
979982002868	effector binding site; other site
979982002869	active site
979982002870	Zn binding site [ion binding]; other site
979982002871	glycine loop; other site
979982002872	acetolactate synthase; Reviewed; Region: PRK08617
979982002873	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
979982002874	PYR/PP interface [polypeptide binding]; other site
979982002875	dimer interface [polypeptide binding]; other site
979982002876	TPP binding site [chemical binding]; other site
979982002877	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
979982002878	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
979982002879	TPP-binding site [chemical binding]; other site
979982002880	GTPase CgtA; Reviewed; Region: obgE; PRK12297
979982002881	GTP1/OBG; Region: GTP1_OBG; pfam01018
979982002882	Obg GTPase; Region: Obg; cd01898
979982002883	G1 box; other site
979982002884	GTP/Mg2+ binding site [chemical binding]; other site
979982002885	Switch I region; other site
979982002886	G2 box; other site
979982002887	G3 box; other site
979982002888	Switch II region; other site
979982002889	G4 box; other site
979982002890	G5 box; other site
979982002891	Domain of unknown function (DUF1967); Region: DUF1967; pfam09269
979982002892	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
979982002893	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
979982002894	GIY-YIG motif/motif A; other site
979982002895	active site
979982002896	catalytic site [active]
979982002897	putative DNA binding site [nucleotide binding]; other site
979982002898	metal binding site [ion binding]; metal-binding site
979982002899	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
979982002900	H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815
979982002901	DNA binding site [nucleotide binding]
979982002902	CTP synthetase; Validated; Region: pyrG; PRK05380
979982002903	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
979982002904	Catalytic site [active]
979982002905	active site
979982002906	UTP binding site [chemical binding]; other site
979982002907	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
979982002908	active site
979982002909	putative oxyanion hole; other site
979982002910	catalytic triad [active]
979982002911	Predicted RNA-binding protein, contains TRAM domain [General function prediction only]; Region: COG3269
979982002912	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
979982002913	putative lipid kinase; Reviewed; Region: PRK13055
979982002914	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
979982002915	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
979982002916	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
979982002917	GatB domain; Region: GatB_Yqey; smart00845
979982002918	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
979982002919	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
979982002920	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
979982002921	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
979982002922	16S/18S rRNA binding site [nucleotide binding]; other site
979982002923	S13e-L30e interaction site [polypeptide binding]; other site
979982002924	25S rRNA binding site [nucleotide binding]; other site
979982002925	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
979982002926	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574
979982002927	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
979982002928	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
979982002929	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
979982002930	Competence protein; Region: Competence; pfam03772
979982002931	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
979982002932	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
979982002933	SLBB domain; Region: SLBB; pfam10531
979982002934	comEA protein; Region: comE; TIGR01259
979982002935	Helix-hairpin-helix motif; Region: HHH; pfam00633
979982002936	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
979982002937	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354
979982002938	Substrate binding site; other site
979982002939	Mg++ binding site; other site
979982002940	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
979982002941	active site
979982002942	substrate binding site [chemical binding]; other site
979982002943	CoA binding site [chemical binding]; other site
979982002944	pur operon repressor; Provisional; Region: PRK09213
979982002945	Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182
979982002946	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
979982002947	active site
979982002948	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
979982002949	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
979982002950	putative PBP binding regions; other site
979982002951	ABC-ATPase subunit  interface; other site
979982002952	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
979982002953	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
979982002954	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
979982002955	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
979982002956	intersubunit interface [polypeptide binding]; other site
979982002957	Protein of unknown function (DUF1021); Region: DUF1021; pfam06257
979982002958	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
979982002959	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
979982002960	S-adenosylmethionine binding site [chemical binding]; other site
979982002961	ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334
979982002962	TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea.  RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027
979982002963	putative active site [active]
979982002964	putative metal binding site [ion binding]; other site
979982002965	Domain of unknown function (DUF4093); Region: DUF4093; pfam13331
979982002966	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
979982002967	active site
979982002968	transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202
979982002969	putative RNA binding site [nucleotide binding]; other site
979982002970	Asp23 family; Region: Asp23; pfam03780
979982002971	elongation factor P; Validated; Region: PRK00529
979982002972	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
979982002973	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
979982002974	RNA binding site [nucleotide binding]; other site
979982002975	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
979982002976	RNA binding site [nucleotide binding]; other site
979982002977	Transcriptional regulators [Transcription]; Region: MarR; COG1846
979982002978	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
979982002979	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
979982002980	Protein of unknown function (DUF1447); Region: DUF1447; pfam07288
979982002981	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
979982002982	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
979982002983	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
979982002984	phosphoenolpyruvate carboxylase; Provisional; Region: PRK13655
979982002985	phosphoenolpyruvate carboxylase, archaeal type; Region: PEPCase_arch; TIGR02751
979982002986	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
979982002987	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
979982002988	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747
979982002989	S-adenosylmethionine synthetase; Validated; Region: PRK05250
979982002990	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
979982002991	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
979982002992	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
979982002993	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493
979982002994	Protein of unknown function (DUF1054); Region: DUF1054; pfam06335
979982002995	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
979982002996	Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432
979982002997	Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432
979982002998	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
979982002999	metal binding site 2 [ion binding]; metal-binding site
979982003000	putative DNA binding helix; other site
979982003001	metal binding site 1 [ion binding]; metal-binding site
979982003002	dimer interface [polypeptide binding]; other site
979982003003	structural Zn2+ binding site [ion binding]; other site
979982003004	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
979982003005	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
979982003006	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
979982003007	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
979982003008	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
979982003009	motif II; other site
979982003010	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
979982003011	Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972
979982003012	Protein of unknown function (DUF2721); Region: DUF2721; pfam11026
979982003013	Protein of unknown function (DUF1275); Region: DUF1275; pfam06912
979982003014	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
979982003015	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
979982003016	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
979982003017	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
979982003018	hypothetical protein; Provisional; Region: PRK06446
979982003019	Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_4; cd05681
979982003020	metal binding site [ion binding]; metal-binding site
979982003021	dimer interface [polypeptide binding]; other site
979982003022	ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135
979982003023	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
979982003024	Walker A/P-loop; other site
979982003025	ATP binding site [chemical binding]; other site
979982003026	Q-loop/lid; other site
979982003027	ABC transporter signature motif; other site
979982003028	Walker B; other site
979982003029	D-loop; other site
979982003030	H-loop/switch region; other site
979982003031	NIL domain; Region: NIL; pfam09383
979982003032	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
979982003033	dimer interface [polypeptide binding]; other site
979982003034	conserved gate region; other site
979982003035	ABC-ATPase subunit interface; other site
979982003036	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
979982003037	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
979982003038	DNA-binding site [nucleotide binding]; DNA binding site
979982003039	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
979982003040	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
979982003041	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
979982003042	active site
979982003043	dimer interface [polypeptide binding]; other site
979982003044	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
979982003045	tetramer interfaces [polypeptide binding]; other site
979982003046	binuclear metal-binding site [ion binding]; other site
979982003047	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
979982003048	RibD C-terminal domain; Region: RibD_C; cl17279
979982003049	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
979982003050	ABC-type cobalt transport system, permease component; Region: ABC_cobalt; pfam09819
979982003051	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
979982003052	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
979982003053	Walker A/P-loop; other site
979982003054	ATP binding site [chemical binding]; other site
979982003055	Q-loop/lid; other site
979982003056	ABC transporter signature motif; other site
979982003057	Walker B; other site
979982003058	D-loop; other site
979982003059	H-loop/switch region; other site
979982003060	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
979982003061	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
979982003062	Walker A/P-loop; other site
979982003063	ATP binding site [chemical binding]; other site
979982003064	Q-loop/lid; other site
979982003065	ABC transporter signature motif; other site
979982003066	Walker B; other site
979982003067	D-loop; other site
979982003068	H-loop/switch region; other site
979982003069	Cobalt transport protein; Region: CbiQ; cl00463
979982003070	TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243
979982003071	Topoisomerase IA [DNA replication, recombination, and repair]; Region: TopA; COG0550
979982003072	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
979982003073	active site
979982003074	putative interdomain interaction site [polypeptide binding]; other site
979982003075	putative metal-binding site [ion binding]; other site
979982003076	putative nucleotide binding site [chemical binding]; other site
979982003077	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cl11986
979982003078	domain I; other site
979982003079	DNA binding groove [nucleotide binding]
979982003080	phosphate binding site [ion binding]; other site
979982003081	domain II; other site
979982003082	domain III; other site
979982003083	nucleotide binding site [chemical binding]; other site
979982003084	catalytic site [active]
979982003085	domain IV; other site
979982003086	Protein of unknown function (DUF3021); Region: DUF3021; pfam11457
979982003087	LytTr DNA-binding domain; Region: LytTR; smart00850
979982003088	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
979982003089	ligand binding site [chemical binding]; other site
979982003090	flexible hinge region; other site
979982003091	HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB
979982003092	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
979982003093	motif II; other site
979982003094	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
979982003095	active site
979982003096	HIGH motif; other site
979982003097	nucleotide binding site [chemical binding]; other site
979982003098	FtsX-like permease family; Region: FtsX; pfam02687
979982003099	FtsX-like permease family; Region: FtsX; pfam02687
979982003100	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
979982003101	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
979982003102	Walker A/P-loop; other site
979982003103	ATP binding site [chemical binding]; other site
979982003104	Q-loop/lid; other site
979982003105	ABC transporter signature motif; other site
979982003106	Walker B; other site
979982003107	D-loop; other site
979982003108	H-loop/switch region; other site
979982003109	Predicted transcriptional regulators [Transcription]; Region: COG1733
979982003110	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
979982003111	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
979982003112	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
979982003113	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4487
979982003114	Uncharacterized protein conserved in bacteria (DUF2130); Region: DUF2130; pfam09903
979982003115	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
979982003116	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
979982003117	putative substrate translocation pore; other site
979982003118	Major Facilitator Superfamily; Region: MFS_1; pfam07690
979982003119	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
979982003120	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
979982003121	active site
979982003122	metal binding site [ion binding]; metal-binding site
979982003123	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
979982003124	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
979982003125	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
979982003126	dimer interface [polypeptide binding]; other site
979982003127	putative anticodon binding site; other site
979982003128	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
979982003129	motif 1; other site
979982003130	active site
979982003131	motif 2; other site
979982003132	motif 3; other site
979982003133	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
979982003134	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
979982003135	dimerization interface [polypeptide binding]; other site
979982003136	domain crossover interface; other site
979982003137	redox-dependent activation switch; other site
979982003138	ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465
979982003139	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
979982003140	Walker A motif; other site
979982003141	ATP binding site [chemical binding]; other site
979982003142	Walker B motif; other site
979982003143	arginine finger; other site
979982003144	Peptidase family M41; Region: Peptidase_M41; pfam01434
979982003145	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
979982003146	active site
979982003147	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
979982003148	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
979982003149	Ligand Binding Site [chemical binding]; other site
979982003150	TilS substrate C-terminal domain; Region: TilS_C; smart00977
979982003151	Septum formation initiator; Region: DivIC; pfam04977
979982003152	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
979982003153	RNA binding surface [nucleotide binding]; other site
979982003154	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
979982003155	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
979982003156	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
979982003157	ATP binding site [chemical binding]; other site
979982003158	putative Mg++ binding site [ion binding]; other site
979982003159	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
979982003160	nucleotide binding region [chemical binding]; other site
979982003161	ATP-binding site [chemical binding]; other site
979982003162	TRCF domain; Region: TRCF; pfam03461
979982003163	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
979982003164	putative active site [active]
979982003165	catalytic residue [active]
979982003166	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
979982003167	1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; cl17224
979982003168	UbiA prenyltransferase family; Region: UbiA; pfam01040
979982003169	Predicted membrane protein [Function unknown]; Region: COG2323
979982003170	Protein of unknown function (DUF3290); Region: DUF3290; pfam11694
979982003171	Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585
979982003172	trimer interface [polypeptide binding]; other site
979982003173	active site
979982003174	G bulge; other site
979982003175	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
979982003176	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
979982003177	putative substrate translocation pore; other site
979982003178	Predicted transcriptional regulators [Transcription]; Region: COG1695
979982003179	Transcriptional regulator PadR-like family; Region: PadR; cl17335
979982003180	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
979982003181	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
979982003182	ring oligomerisation interface [polypeptide binding]; other site
979982003183	ATP/Mg binding site [chemical binding]; other site
979982003184	stacking interactions; other site
979982003185	hinge regions; other site
979982003186	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
979982003187	oligomerisation interface [polypeptide binding]; other site
979982003188	mobile loop; other site
979982003189	roof hairpin; other site
979982003190	Uncharacterized conserved protein [Function unknown]; Region: COG1284
979982003191	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
979982003192	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
979982003193	Domain of unknown function (DUF956); Region: DUF956; cl01917
979982003194	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716
979982003195	PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065
979982003196	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
979982003197	PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088
979982003198	active pocket/dimerization site; other site
979982003199	active site
979982003200	phosphorylation site [posttranslational modification]
979982003201	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
979982003202	active site
979982003203	phosphorylation site [posttranslational modification]
979982003204	Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482
979982003205	mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218
979982003206	CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421
979982003207	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
979982003208	DXD motif; other site
979982003209	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
979982003210	Ligand binding site; other site
979982003211	Putative Catalytic site; other site
979982003212	DXD motif; other site
979982003213	Predicted membrane protein [Function unknown]; Region: COG2246
979982003214	GtrA-like protein; Region: GtrA; pfam04138
979982003215	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
979982003216	non-specific DNA binding site [nucleotide binding]; other site
979982003217	salt bridge; other site
979982003218	sequence-specific DNA binding site [nucleotide binding]; other site
979982003219	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
979982003220	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
979982003221	non-specific DNA binding site [nucleotide binding]; other site
979982003222	salt bridge; other site
979982003223	sequence-specific DNA binding site [nucleotide binding]; other site
979982003224	Domain of unknown function (DUF955); Region: DUF955; cl01076
979982003225	This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146
979982003226	dimer interface [polypeptide binding]; other site
979982003227	FMN binding site [chemical binding]; other site
979982003228	NADPH bind site [chemical binding]; other site
979982003229	Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081
979982003230	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
979982003231	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
979982003232	active site
979982003233	motif I; other site
979982003234	motif II; other site
979982003235	Predicted membrane protein [Function unknown]; Region: COG2246
979982003236	GtrA-like protein; Region: GtrA; pfam04138
979982003237	Peptidoglycan interpeptide bridge formation enzyme [Cell wall/membrane/envelope biogenesis]; Region: COG2348
979982003238	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
979982003239	redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472
979982003240	Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971
979982003241	CoA binding domain; Region: CoA_binding; pfam02629
979982003242	UGMP family protein; Validated; Region: PRK09604
979982003243	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884
979982003244	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
979982003245	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
979982003246	Coenzyme A binding pocket [chemical binding]; other site
979982003247	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
979982003248	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
979982003249	Coenzyme A binding pocket [chemical binding]; other site
979982003250	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
979982003251	Glycoprotease family; Region: Peptidase_M22; pfam00814
979982003252	Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791
979982003253	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
979982003254	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
979982003255	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
979982003256	DNA binding residues [nucleotide binding]
979982003257	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
979982003258	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
979982003259	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
979982003260	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
979982003261	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
979982003262	dimerization domain swap beta strand [polypeptide binding]; other site
979982003263	regulatory protein interface [polypeptide binding]; other site
979982003264	active site
979982003265	regulatory phosphorylation site [posttranslational modification]; other site
979982003266	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
979982003267	Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481
979982003268	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
979982003269	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
979982003270	S-adenosylmethionine binding site [chemical binding]; other site
979982003271	peptide chain release factor 1; Validated; Region: prfA; PRK00591
979982003272	This domain is found in peptide chain release factors; Region: PCRF; smart00937
979982003273	RF-1 domain; Region: RF-1; pfam00472
979982003274	thymidine kinase; Provisional; Region: PRK04296
979982003275	glucan-binding repeat; Region: glucan_65_rpt; TIGR04035
979982003276	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
979982003277	NlpC/P60 family; Region: NLPC_P60; cl17555
979982003278	UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769
979982003279	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
979982003280	Domain of unknown function (DUF1727); Region: DUF1727; pfam08353
979982003281	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
979982003282	catalytic triad [active]
979982003283	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
979982003284	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
979982003285	Ca binding site [ion binding]; other site
979982003286	active site
979982003287	catalytic site [active]
979982003288	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
979982003289	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
979982003290	Major Facilitator Superfamily; Region: MFS_1; pfam07690
979982003291	putative substrate translocation pore; other site
979982003292	Transcriptional regulators [Transcription]; Region: PurR; COG1609
979982003293	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
979982003294	DNA binding site [nucleotide binding]
979982003295	domain linker motif; other site
979982003296	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
979982003297	dimerization interface [polypeptide binding]; other site
979982003298	ligand binding site [chemical binding]; other site
979982003299	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
979982003300	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
979982003301	Peptidase C26; Region: Peptidase_C26; pfam07722
979982003302	catalytic triad [active]
979982003303	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
979982003304	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
979982003305	peptide binding site [polypeptide binding]; other site
979982003306	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
979982003307	substrate binding site [chemical binding]; other site
979982003308	THF binding site; other site
979982003309	zinc-binding site [ion binding]; other site
979982003310	O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873
979982003311	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
979982003312	homodimer interface [polypeptide binding]; other site
979982003313	substrate-cofactor binding pocket; other site
979982003314	pyridoxal 5'-phosphate binding site [chemical binding]; other site
979982003315	catalytic residue [active]
979982003316	S-ribosylhomocysteinase; Provisional; Region: PRK02260
979982003317	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
979982003318	substrate binding site [chemical binding]; other site
979982003319	zinc-binding site [ion binding]; other site
979982003320	cystathionine beta-lyase; Provisional; Region: PRK08064
979982003321	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
979982003322	homodimer interface [polypeptide binding]; other site
979982003323	substrate-cofactor binding pocket; other site
979982003324	pyridoxal 5'-phosphate binding site [chemical binding]; other site
979982003325	catalytic residue [active]
979982003326	cystathionine gamma-synthase; Reviewed; Region: PRK08247
979982003327	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
979982003328	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
979982003329	catalytic residue [active]
979982003330	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
979982003331	conserved cys residue [active]
979982003332	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
979982003333	catalytic residues [active]
979982003334	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
979982003335	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
979982003336	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
979982003337	dimer interface [polypeptide binding]; other site
979982003338	phosphorylation site [posttranslational modification]
979982003339	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
979982003340	ATP binding site [chemical binding]; other site
979982003341	Mg2+ binding site [ion binding]; other site
979982003342	G-X-G motif; other site
979982003343	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
979982003344	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
979982003345	active site
979982003346	phosphorylation site [posttranslational modification]
979982003347	intermolecular recognition site; other site
979982003348	dimerization interface [polypeptide binding]; other site
979982003349	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
979982003350	DNA binding site [nucleotide binding]
979982003351	High-affinity nickel-transport protein; Region: NicO; cl00964
979982003352	Telomere recombination; Region: Sua5_yciO_yrdC; cl00305
979982003353	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
979982003354	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
979982003355	substrate binding site [chemical binding]; other site
979982003356	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
979982003357	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
979982003358	substrate binding site [chemical binding]; other site
979982003359	ligand binding site [chemical binding]; other site
979982003360	Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445
979982003361	Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445
979982003362	Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119
979982003363	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
979982003364	active site
979982003365	catalytic residues [active]
979982003366	metal binding site [ion binding]; metal-binding site
979982003367	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
979982003368	FeS assembly protein SufB; Region: sufB; TIGR01980
979982003369	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
979982003370	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
979982003371	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
979982003372	trimerization site [polypeptide binding]; other site
979982003373	active site
979982003374	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
979982003375	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
979982003376	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
979982003377	catalytic residue [active]
979982003378	Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719
979982003379	FeS assembly protein SufD; Region: sufD; TIGR01981
979982003380	Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396
979982003381	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
979982003382	Walker A/P-loop; other site
979982003383	ATP binding site [chemical binding]; other site
979982003384	Q-loop/lid; other site
979982003385	ABC transporter signature motif; other site
979982003386	Walker B; other site
979982003387	D-loop; other site
979982003388	H-loop/switch region; other site
979982003389	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
979982003390	non-specific DNA binding site [nucleotide binding]; other site
979982003391	salt bridge; other site
979982003392	sequence-specific DNA binding site [nucleotide binding]; other site
979982003393	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
979982003394	DEAD-like helicases superfamily; Region: DEXDc; smart00487
979982003395	ATP binding site [chemical binding]; other site
979982003396	putative Mg++ binding site [ion binding]; other site
979982003397	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
979982003398	nucleotide binding region [chemical binding]; other site
979982003399	ATP-binding site [chemical binding]; other site
979982003400	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
979982003401	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
979982003402	Uncharacterized bacterial muramidase containing a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis...; Region: GH25_muramidase_2; cd06419
979982003403	active site
979982003404	Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073
979982003405	Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309
979982003406	Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345
979982003407	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
979982003408	Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428
979982003409	Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673
979982003410	Substrate-binding site [chemical binding]; other site
979982003411	Substrate specificity [chemical binding]; other site
979982003412	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
979982003413	biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244
979982003414	NADH(P)-binding; Region: NAD_binding_10; pfam13460
979982003415	NAD binding site [chemical binding]; other site
979982003416	substrate binding site [chemical binding]; other site
979982003417	putative active site [active]
979982003418	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
979982003419	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
979982003420	NAD binding site [chemical binding]; other site
979982003421	homodimer interface [polypeptide binding]; other site
979982003422	active site
979982003423	substrate binding site [chemical binding]; other site
979982003424	Acyl-ACP thioesterase [Lipid metabolism]; Region: FatA; COG3884
979982003425	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
979982003426	active site
979982003427	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
979982003428	active site 2 [active]
979982003429	active site 1 [active]
979982003430	Predicted methyltransferases [General function prediction only]; Region: COG0313
979982003431	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
979982003432	putative SAM binding site [chemical binding]; other site
979982003433	putative homodimer interface [polypeptide binding]; other site
979982003434	DNA polymerase III subunit delta'; Validated; Region: PRK08058
979982003435	DNA polymerase III subunit delta'; Validated; Region: PRK08485
979982003436	Protein of unknown function (DUF970); Region: DUF970; cl17525
979982003437	thymidylate kinase; Validated; Region: tmk; PRK00698
979982003438	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
979982003439	TMP-binding site; other site
979982003440	ATP-binding site [chemical binding]; other site
979982003441	Protein of unknown function (DUF2508); Region: DUF2508; pfam10704
979982003442	recombination protein RecR; Reviewed; Region: recR; PRK00076
979982003443	RecR protein; Region: RecR; pfam02132
979982003444	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
979982003445	putative active site [active]
979982003446	putative metal-binding site [ion binding]; other site
979982003447	tetramer interface [polypeptide binding]; other site
979982003448	DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563
979982003449	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
979982003450	Walker A motif; other site
979982003451	ATP binding site [chemical binding]; other site
979982003452	Walker B motif; other site
979982003453	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
979982003454	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
979982003455	Zn2+ binding site [ion binding]; other site
979982003456	Mg2+ binding site [ion binding]; other site
979982003457	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
979982003458	nucleoside/Zn binding site; other site
979982003459	dimer interface [polypeptide binding]; other site
979982003460	catalytic motif [active]
979982003461	Methyltransferase domain; Region: Methyltransf_31; pfam13847
979982003462	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
979982003463	S-adenosylmethionine binding site [chemical binding]; other site
979982003464	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
979982003465	peripheral dimer interface [polypeptide binding]; other site
979982003466	core dimer interface [polypeptide binding]; other site
979982003467	L10 interface [polypeptide binding]; other site
979982003468	L11 interface [polypeptide binding]; other site
979982003469	putative EF-Tu interaction site [polypeptide binding]; other site
979982003470	putative EF-G interaction site [polypeptide binding]; other site
979982003471	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
979982003472	23S rRNA interface [nucleotide binding]; other site
979982003473	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
979982003474	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
979982003475	mRNA/rRNA interface [nucleotide binding]; other site
979982003476	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
979982003477	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
979982003478	23S rRNA interface [nucleotide binding]; other site
979982003479	L7/L12 interface [polypeptide binding]; other site
979982003480	putative thiostrepton binding site; other site
979982003481	L25 interface [polypeptide binding]; other site
979982003482	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
979982003483	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
979982003484	putative homodimer interface [polypeptide binding]; other site
979982003485	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
979982003486	heterodimer interface [polypeptide binding]; other site
979982003487	homodimer interface [polypeptide binding]; other site
979982003488	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597
979982003489	50S ribosomal protein L33; Validated; Region: rpmG; PRK00504
979982003490	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
979982003491	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
979982003492	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
979982003493	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
979982003494	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
979982003495	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
979982003496	30S subunit binding site; other site
979982003497	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
979982003498	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
979982003499	active site
979982003500	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
979982003501	ATP binding site [chemical binding]; other site
979982003502	putative Mg++ binding site [ion binding]; other site
979982003503	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
979982003504	nucleotide binding region [chemical binding]; other site
979982003505	ATP-binding site [chemical binding]; other site
979982003506	Uncharacterized conserved protein [Function unknown]; Region: COG1739
979982003507	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
979982003508	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
979982003509	exopolyphosphatase; Region: exo_poly_only; TIGR03706
979982003510	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
979982003511	polyphosphate kinase; Provisional; Region: PRK05443
979982003512	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
979982003513	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
979982003514	Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165
979982003515	putative domain interface [polypeptide binding]; other site
979982003516	putative active site [active]
979982003517	catalytic site [active]
979982003518	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
979982003519	putative domain interface [polypeptide binding]; other site
979982003520	putative active site [active]
979982003521	catalytic site [active]
979982003522	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
979982003523	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
979982003524	Zn2+ binding site [ion binding]; other site
979982003525	Mg2+ binding site [ion binding]; other site
979982003526	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
979982003527	enolase; Provisional; Region: eno; PRK00077
979982003528	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
979982003529	dimer interface [polypeptide binding]; other site
979982003530	metal binding site [ion binding]; metal-binding site
979982003531	substrate binding pocket [chemical binding]; other site
979982003532	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
979982003533	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
979982003534	rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186
979982003535	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
979982003536	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
979982003537	Ribonuclease III family protein [Replication, recombination, and    repair]; Region: COG1939
979982003538	active site
979982003539	metal binding site [ion binding]; metal-binding site
979982003540	dimerization interface [polypeptide binding]; other site
979982003541	DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566
979982003542	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
979982003543	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
979982003544	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
979982003545	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
979982003546	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
979982003547	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
979982003548	DNA binding site [nucleotide binding]
979982003549	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
979982003550	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
979982003551	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
979982003552	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
979982003553	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
979982003554	RPB1 interaction site [polypeptide binding]; other site
979982003555	RPB10 interaction site [polypeptide binding]; other site
979982003556	RPB11 interaction site [polypeptide binding]; other site
979982003557	RPB3 interaction site [polypeptide binding]; other site
979982003558	RPB12 interaction site [polypeptide binding]; other site
979982003559	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
979982003560	triosephosphate isomerase; Provisional; Region: PRK14565
979982003561	substrate binding site [chemical binding]; other site
979982003562	dimer interface [polypeptide binding]; other site
979982003563	catalytic triad [active]
979982003564	Enterocin A Immunity; Region: EntA_Immun; pfam08951
979982003565	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
979982003566	DNA-binding site [nucleotide binding]; DNA binding site
979982003567	RNA-binding motif; other site
979982003568	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
979982003569	catalytic core [active]
979982003570	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
979982003571	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
979982003572	active site
979982003573	ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966
979982003574	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
979982003575	dimer interface [polypeptide binding]; other site
979982003576	putative radical transfer pathway; other site
979982003577	diiron center [ion binding]; other site
979982003578	tyrosyl radical; other site
979982003579	NrdI Flavodoxin like; Region: Flavodoxin_NdrI; cl17293
979982003580	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07306
979982003581	Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343
979982003582	Class I ribonucleotide reductase; Region: RNR_I; cd01679
979982003583	active site
979982003584	dimer interface [polypeptide binding]; other site
979982003585	catalytic residues [active]
979982003586	effector binding site; other site
979982003587	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
979982003588	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
979982003589	catalytic residues [active]
979982003590	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
979982003591	Domain of unknown function DUF21; Region: DUF21; pfam01595
979982003592	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
979982003593	Transporter associated domain; Region: CorC_HlyC; smart01091
979982003594	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
979982003595	catalytic core [active]
979982003596	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
979982003597	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
979982003598	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
979982003599	HflX GTPase family; Region: HflX; cd01878
979982003600	G1 box; other site
979982003601	GTP/Mg2+ binding site [chemical binding]; other site
979982003602	Switch I region; other site
979982003603	G2 box; other site
979982003604	G3 box; other site
979982003605	Switch II region; other site
979982003606	G4 box; other site
979982003607	G5 box; other site
979982003608	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
979982003609	Major Facilitator Superfamily; Region: MFS_1; pfam07690
979982003610	putative substrate translocation pore; other site
979982003611	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
979982003612	DEAD-like helicases superfamily; Region: DEXDc; smart00487
979982003613	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
979982003614	ATP binding site [chemical binding]; other site
979982003615	putative Mg++ binding site [ion binding]; other site
979982003616	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
979982003617	nucleotide binding region [chemical binding]; other site
979982003618	ATP-binding site [chemical binding]; other site
979982003619	type III restriction-modification system StyLTI enzyme res; Provisional; Region: PRK15483
979982003620	Type III restriction enzyme, res subunit; Region: ResIII; pfam04851
979982003621	Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189
979982003622	DNA methylase; Region: N6_N4_Mtase; pfam01555
979982003623	DNA methylase; Region: N6_N4_Mtase; cl17433
979982003624	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
979982003625	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
979982003626	23S rRNA interface [nucleotide binding]; other site
979982003627	L3 interface [polypeptide binding]; other site
979982003628	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
979982003629	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
979982003630	dimerization interface 3.5A [polypeptide binding]; other site
979982003631	active site
979982003632	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
979982003633	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634
979982003634	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
979982003635	Walker A/P-loop; other site
979982003636	ATP binding site [chemical binding]; other site
979982003637	Q-loop/lid; other site
979982003638	ABC transporter signature motif; other site
979982003639	Walker B; other site
979982003640	D-loop; other site
979982003641	H-loop/switch region; other site
979982003642	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635
979982003643	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
979982003644	Walker A/P-loop; other site
979982003645	ATP binding site [chemical binding]; other site
979982003646	Q-loop/lid; other site
979982003647	ABC transporter signature motif; other site
979982003648	Walker B; other site
979982003649	D-loop; other site
979982003650	H-loop/switch region; other site
979982003651	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
979982003652	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
979982003653	DoxX; Region: DoxX; pfam07681
979982003654	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
979982003655	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
979982003656	substrate binding pocket [chemical binding]; other site
979982003657	chain length determination region; other site
979982003658	substrate-Mg2+ binding site; other site
979982003659	catalytic residues [active]
979982003660	aspartate-rich region 1; other site
979982003661	active site lid residues [active]
979982003662	aspartate-rich region 2; other site
979982003663	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
979982003664	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
979982003665	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
979982003666	alphaNTD - beta interaction site [polypeptide binding]; other site
979982003667	alphaNTD homodimer interface [polypeptide binding]; other site
979982003668	alphaNTD - beta' interaction site [polypeptide binding]; other site
979982003669	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
979982003670	30S ribosomal protein S11; Validated; Region: PRK05309
979982003671	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
979982003672	30S ribosomal protein S13; Region: bact_S13; TIGR03631
979982003673	Ribosomal protein L36; Region: Ribosomal_L36; pfam00444
979982003674	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
979982003675	rRNA binding site [nucleotide binding]; other site
979982003676	predicted 30S ribosome binding site; other site
979982003677	adenylate kinase; Reviewed; Region: adk; PRK00279
979982003678	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
979982003679	AMP-binding site [chemical binding]; other site
979982003680	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
979982003681	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
979982003682	SecY translocase; Region: SecY; pfam00344
979982003683	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
979982003684	50S ribosomal protein L30; Reviewed; Region: rpmD; PRK05611
979982003685	23S rRNA binding site - archaea [nucleotide binding]; other site
979982003686	23S rRNA binding site - prokaryotes [nucleotide binding]; other site
979982003687	5S rRNA binding site - archaea; other site
979982003688	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
979982003689	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
979982003690	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
979982003691	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
979982003692	5S rRNA interface [nucleotide binding]; other site
979982003693	L27 interface [polypeptide binding]; other site
979982003694	23S rRNA interface [nucleotide binding]; other site
979982003695	L5 interface [polypeptide binding]; other site
979982003696	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
979982003697	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
979982003698	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
979982003699	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
979982003700	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
979982003701	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
979982003702	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
979982003703	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
979982003704	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
979982003705	RNA binding site [nucleotide binding]; other site
979982003706	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
979982003707	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
979982003708	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
979982003709	putative translocon interaction site; other site
979982003710	23S rRNA interface [nucleotide binding]; other site
979982003711	signal recognition particle (SRP54) interaction site; other site
979982003712	L23 interface [polypeptide binding]; other site
979982003713	trigger factor interaction site; other site
979982003714	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
979982003715	23S rRNA interface [nucleotide binding]; other site
979982003716	5S rRNA interface [nucleotide binding]; other site
979982003717	putative antibiotic binding site [chemical binding]; other site
979982003718	L25 interface [polypeptide binding]; other site
979982003719	L27 interface [polypeptide binding]; other site
979982003720	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
979982003721	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
979982003722	G-X-X-G motif; other site
979982003723	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
979982003724	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
979982003725	putative translocon binding site; other site
979982003726	protein-rRNA interface [nucleotide binding]; other site
979982003727	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
979982003728	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
979982003729	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
979982003730	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
979982003731	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
979982003732	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
979982003733	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
979982003734	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
979982003735	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
979982003736	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
979982003737	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
979982003738	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
979982003739	dimer interface [polypeptide binding]; other site
979982003740	conserved gate region; other site
979982003741	ABC-ATPase subunit interface; other site
979982003742	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
979982003743	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
979982003744	dimer interface [polypeptide binding]; other site
979982003745	conserved gate region; other site
979982003746	putative PBP binding loops; other site
979982003747	ABC-ATPase subunit interface; other site
979982003748	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
979982003749	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
979982003750	Walker A/P-loop; other site
979982003751	ATP binding site [chemical binding]; other site
979982003752	Q-loop/lid; other site
979982003753	ABC transporter signature motif; other site
979982003754	Walker B; other site
979982003755	D-loop; other site
979982003756	H-loop/switch region; other site
979982003757	TOBE domain; Region: TOBE_2; pfam08402
979982003758	Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807
979982003759	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
979982003760	putative substrate translocation pore; other site
979982003761	elongation factor G; Reviewed; Region: PRK12739
979982003762	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
979982003763	G1 box; other site
979982003764	putative GEF interaction site [polypeptide binding]; other site
979982003765	GTP/Mg2+ binding site [chemical binding]; other site
979982003766	Switch I region; other site
979982003767	G2 box; other site
979982003768	G3 box; other site
979982003769	Switch II region; other site
979982003770	G4 box; other site
979982003771	G5 box; other site
979982003772	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
979982003773	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
979982003774	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
979982003775	30S ribosomal protein S7; Validated; Region: PRK05302
979982003776	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
979982003777	S17 interaction site [polypeptide binding]; other site
979982003778	S8 interaction site; other site
979982003779	16S rRNA interaction site [nucleotide binding]; other site
979982003780	streptomycin interaction site [chemical binding]; other site
979982003781	23S rRNA interaction site [nucleotide binding]; other site
979982003782	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
979982003783	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
979982003784	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
979982003785	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
979982003786	Clp amino terminal domain; Region: Clp_N; pfam02861
979982003787	Clp amino terminal domain; Region: Clp_N; pfam02861
979982003788	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
979982003789	Walker A motif; other site
979982003790	ATP binding site [chemical binding]; other site
979982003791	Walker B motif; other site
979982003792	arginine finger; other site
979982003793	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
979982003794	Walker A motif; other site
979982003795	ATP binding site [chemical binding]; other site
979982003796	Walker B motif; other site
979982003797	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
979982003798	peptide chain release factor 2; Provisional; Region: PRK05589
979982003799	This domain is found in peptide chain release factors; Region: PCRF; smart00937
979982003800	RF-1 domain; Region: RF-1; pfam00472
979982003801	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
979982003802	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
979982003803	seryl-tRNA synthetase; Provisional; Region: PRK05431
979982003804	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
979982003805	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
979982003806	dimer interface [polypeptide binding]; other site
979982003807	active site
979982003808	motif 1; other site
979982003809	motif 2; other site
979982003810	motif 3; other site
979982003811	potential protein location (hypothetical protein LGMK_05695 [Leuconostoc sp. C2]) that overlaps RNA (tRNA-A)
979982003812	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
979982003813	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
979982003814	active site
979982003815	HIGH motif; other site
979982003816	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
979982003817	KMSKS motif; other site
979982003818	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
979982003819	tRNA binding surface [nucleotide binding]; other site
979982003820	anticodon binding site; other site
979982003821	Phosphoglycerate kinase; Region: PGK; pfam00162
979982003822	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
979982003823	substrate binding site [chemical binding]; other site
979982003824	hinge regions; other site
979982003825	ADP binding site [chemical binding]; other site
979982003826	catalytic site [active]
979982003827	accessory Sec system glycosyltransferase GtfB; Region: TIGR02919
979982003828	Domain of unknown function (DUF1975); Region: DUF1975; pfam09318
979982003829	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
979982003830	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
979982003831	Major Facilitator Superfamily; Region: MFS_1; pfam07690
979982003832	putative substrate translocation pore; other site
979982003833	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
979982003834	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
979982003835	AAA domain; Region: AAA_18; pfam13238
979982003836	active site
979982003837	Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973
979982003838	Part of AAA domain; Region: AAA_19; pfam13245
979982003839	Family description; Region: UvrD_C_2; pfam13538
979982003840	Old yellow enzyme (OYE)-related FMN binding domain, group 4.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735
979982003841	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
979982003842	putative active site [active]
979982003843	putative FMN binding site [chemical binding]; other site
979982003844	putative substrate binding site [chemical binding]; other site
979982003845	putative catalytic residue [active]
979982003846	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
979982003847	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
979982003848	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
979982003849	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
979982003850	active site
979982003851	metal binding site [ion binding]; metal-binding site
979982003852	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
979982003853	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
979982003854	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
979982003855	dimer interface [polypeptide binding]; other site
979982003856	conserved gate region; other site
979982003857	ABC-ATPase subunit interface; other site
979982003858	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
979982003859	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
979982003860	dimer interface [polypeptide binding]; other site
979982003861	conserved gate region; other site
979982003862	putative PBP binding loops; other site
979982003863	ABC-ATPase subunit interface; other site
979982003864	ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638
979982003865	ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256
979982003866	Walker A/P-loop; other site
979982003867	ATP binding site [chemical binding]; other site
979982003868	Q-loop/lid; other site
979982003869	ABC transporter signature motif; other site
979982003870	Walker B; other site
979982003871	D-loop; other site
979982003872	H-loop/switch region; other site
979982003873	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974
979982003874	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
979982003875	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
979982003876	gamma subunit interface [polypeptide binding]; other site
979982003877	epsilon subunit interface [polypeptide binding]; other site
979982003878	LBP interface [polypeptide binding]; other site
979982003879	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
979982003880	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
979982003881	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
979982003882	alpha subunit interaction interface [polypeptide binding]; other site
979982003883	Walker A motif; other site
979982003884	ATP binding site [chemical binding]; other site
979982003885	Walker B motif; other site
979982003886	inhibitor binding site; inhibition site
979982003887	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
979982003888	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
979982003889	core domain interface [polypeptide binding]; other site
979982003890	delta subunit interface [polypeptide binding]; other site
979982003891	epsilon subunit interface [polypeptide binding]; other site
979982003892	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
979982003893	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
979982003894	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
979982003895	beta subunit interaction interface [polypeptide binding]; other site
979982003896	Walker A motif; other site
979982003897	ATP binding site [chemical binding]; other site
979982003898	Walker B motif; other site
979982003899	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
979982003900	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
979982003901	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
979982003902	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
979982003903	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
979982003904	F0F1 ATP synthase subunit C; Validated; Region: PRK06876
979982003905	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
979982003906	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
979982003907	uracil transporter; Provisional; Region: PRK10720
979982003908	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
979982003909	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
979982003910	G1 box; other site
979982003911	putative GEF interaction site [polypeptide binding]; other site
979982003912	GTP/Mg2+ binding site [chemical binding]; other site
979982003913	Switch I region; other site
979982003914	G2 box; other site
979982003915	G3 box; other site
979982003916	Switch II region; other site
979982003917	G4 box; other site
979982003918	G5 box; other site
979982003919	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
979982003920	Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124
979982003921	active site
979982003922	zinc binding site [ion binding]; other site
979982003923	YjeF-related protein N-terminus; Region: YjeF_N; pfam03853
979982003924	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
979982003925	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
979982003926	Walker A/P-loop; other site
979982003927	ATP binding site [chemical binding]; other site
979982003928	Q-loop/lid; other site
979982003929	ABC transporter signature motif; other site
979982003930	Walker B; other site
979982003931	D-loop; other site
979982003932	H-loop/switch region; other site
979982003933	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
979982003934	dimer interface [polypeptide binding]; other site
979982003935	conserved gate region; other site
979982003936	putative PBP binding loops; other site
979982003937	ABC-ATPase subunit interface; other site
979982003938	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
979982003939	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
979982003940	dimer interface [polypeptide binding]; other site
979982003941	conserved gate region; other site
979982003942	putative PBP binding loops; other site
979982003943	ABC-ATPase subunit interface; other site
979982003944	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
979982003945	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
979982003946	substrate binding pocket [chemical binding]; other site
979982003947	membrane-bound complex binding site; other site
979982003948	hinge residues; other site
979982003949	The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464
979982003950	The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464
979982003951	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
979982003952	Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272
979982003953	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
979982003954	EDD domain protein, DegV family; Region: DegV; TIGR00762
979982003955	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
979982003956	CrcB-like protein; Region: CRCB; pfam02537
979982003957	CrcB-like protein; Region: CRCB; cl09114
979982003958	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
979982003959	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
979982003960	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
979982003961	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
979982003962	active site
979982003963	phosphorylation site [posttranslational modification]
979982003964	intermolecular recognition site; other site
979982003965	dimerization interface [polypeptide binding]; other site
979982003966	LytTr DNA-binding domain; Region: LytTR; pfam04397
979982003967	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418
979982003968	ABC-type bacteriocin transporter; Region: bacteriocin_ABC; TIGR01193
979982003969	putative active site [active]
979982003970	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
979982003971	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
979982003972	Walker A/P-loop; other site
979982003973	ATP binding site [chemical binding]; other site
979982003974	Q-loop/lid; other site
979982003975	ABC transporter signature motif; other site
979982003976	Walker B; other site
979982003977	D-loop; other site
979982003978	H-loop/switch region; other site
979982003979	bacteriocin secretion accessory protein; Region: bacteriocin_acc; TIGR01000
979982003980	HlyD family secretion protein; Region: HlyD_3; pfam13437
979982003981	amino acid transporter; Region: 2A0306; TIGR00909
979982003982	Amb_all domain; Region: Amb_all; smart00656
979982003983	Major Facilitator Superfamily; Region: MFS_1; pfam07690
979982003984	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
979982003985	putative substrate translocation pore; other site
979982003986	Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501
979982003987	This family represents an uncharacterized glycosyl hydrolase family 31 (GH31) enzyme found in bacteria and eukaryotes that is related to the XylS xylosidase of Sulfolobus solfataricus. Alpha-xylosidases catalyze the release of an alpha-xylose residue...; Region: GH31_xylosidase_XylS-like; cd06595
979982003988	putative active site [active]
979982003989	putative catalytic site [active]
979982003990	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
979982003991	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
979982003992	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
979982003993	putative active site [active]
979982003994	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
979982003995	dimerization interface [polypeptide binding]; other site
979982003996	putative DNA binding site [nucleotide binding]; other site
979982003997	putative Zn2+ binding site [ion binding]; other site
979982003998	Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300
979982003999	Cadmium resistance transporter; Region: Cad; pfam03596
979982004000	Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325
979982004001	zinc binding site [ion binding]; other site
979982004002	putative ligand binding site [chemical binding]; other site
979982004003	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
979982004004	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574
979982004005	TM-ABC transporter signature motif; other site
979982004006	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101
979982004007	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
979982004008	Walker A/P-loop; other site
979982004009	ATP binding site [chemical binding]; other site
979982004010	Q-loop/lid; other site
979982004011	ABC transporter signature motif; other site
979982004012	Walker B; other site
979982004013	D-loop; other site
979982004014	H-loop/switch region; other site
979982004015	L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291
979982004016	tetramer (dimer of dimers) interface [polypeptide binding]; other site
979982004017	L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771
979982004018	NAD binding site [chemical binding]; other site
979982004019	dimer interface [polypeptide binding]; other site
979982004020	substrate binding site [chemical binding]; other site
979982004021	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
979982004022	Arginate lyase and other MDR family members; Region: AL_MDR; cd08252
979982004023	putative NAD(P) binding site [chemical binding]; other site
979982004024	dimer interface [polypeptide binding]; other site
979982004025	Predicted transcriptional regulators [Transcription]; Region: COG1733
979982004026	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
979982004027	Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091
979982004028	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
979982004029	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
979982004030	Major Facilitator Superfamily; Region: MFS_1; pfam07690
979982004031	putative substrate translocation pore; other site
979982004032	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
979982004033	dimerization interface [polypeptide binding]; other site
979982004034	putative DNA binding site [nucleotide binding]; other site
979982004035	putative Zn2+ binding site [ion binding]; other site
979982004036	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
979982004037	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
979982004038	TM-ABC transporter signature motif; other site
979982004039	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
979982004040	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
979982004041	TM-ABC transporter signature motif; other site
979982004042	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
979982004043	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
979982004044	Walker A/P-loop; other site
979982004045	ATP binding site [chemical binding]; other site
979982004046	Q-loop/lid; other site
979982004047	ABC transporter signature motif; other site
979982004048	Walker B; other site
979982004049	D-loop; other site
979982004050	H-loop/switch region; other site
979982004051	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
979982004052	Major Facilitator Superfamily; Region: MFS_1; pfam07690
979982004053	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
979982004054	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
979982004055	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
979982004056	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
979982004057	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
979982004058	Major Facilitator Superfamily; Region: MFS_1; pfam07690
979982004059	putative substrate translocation pore; other site
979982004060	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
979982004061	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
979982004062	Major Facilitator Superfamily; Region: MFS_1; pfam07690
979982004063	putative substrate translocation pore; other site
979982004064	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
979982004065	NADH(P)-binding; Region: NAD_binding_10; pfam13460
979982004066	NAD(P) binding site [chemical binding]; other site
979982004067	active site
979982004068	Predicted transcriptional regulator [Transcription]; Region: COG1959
979982004069	Transcriptional regulator; Region: Rrf2; pfam02082
979982004070	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
979982004071	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
979982004072	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
979982004073	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
979982004074	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
979982004075	TrkA-N domain; Region: TrkA_N; pfam02254
979982004076	TrkA-C domain; Region: TrkA_C; pfam02080
979982004077	D-lactate dehydrogenase; Provisional; Region: PRK11183
979982004078	FAD binding domain; Region: FAD_binding_4; pfam01565
979982004079	D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330
979982004080	D-ribose transporter subunit RbsB; Provisional; Region: PRK10653
979982004081	Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323
979982004082	ligand binding site [chemical binding]; other site
979982004083	dimerization interface [polypeptide binding]; other site
979982004084	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
979982004085	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
979982004086	TM-ABC transporter signature motif; other site
979982004087	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
979982004088	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
979982004089	Walker A/P-loop; other site
979982004090	ATP binding site [chemical binding]; other site
979982004091	Q-loop/lid; other site
979982004092	ABC transporter signature motif; other site
979982004093	Walker B; other site
979982004094	D-loop; other site
979982004095	H-loop/switch region; other site
979982004096	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
979982004097	D-ribose pyranase; Provisional; Region: PRK11797
979982004098	Zinc-dependent metalloprotease, MMP_like subfamily. This group contains matrix metalloproteinases (MMPs), serralysins, and the astacin_like family of proteases; Region: ZnMc_MMP_like; cd04268
979982004099	active site
979982004100	OsmC-like protein; Region: OsmC; cl00767
979982004101	Predicted transcriptional regulators [Transcription]; Region: COG1695
979982004102	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
979982004103	Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249
979982004104	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
979982004105	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
979982004106	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
979982004107	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
979982004108	Major Facilitator Superfamily; Region: MFS_1; pfam07690
979982004109	putative substrate translocation pore; other site
979982004110	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
979982004111	dimerization interface [polypeptide binding]; other site
979982004112	putative DNA binding site [nucleotide binding]; other site
979982004113	putative Zn2+ binding site [ion binding]; other site
979982004114	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
979982004115	putative substrate translocation pore; other site
979982004116	H+ Antiporter protein; Region: 2A0121; TIGR00900
979982004117	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
979982004118	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
979982004119	non-specific DNA binding site [nucleotide binding]; other site
979982004120	salt bridge; other site
979982004121	sequence-specific DNA binding site [nucleotide binding]; other site
979982004122	Glycosyl hydrolases family 32 N-terminal domain; Region: Glyco_hydro_32N; pfam00251
979982004123	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
979982004124	substrate binding [chemical binding]; other site
979982004125	active site
979982004126	potential frameshift: common BLAST hit: gi|296111315|ref|YP_003621697.1| GTP-binding translation elongation factor LepA
979982004127	Predicted transcriptional regulator [Transcription]; Region: COG2378
979982004128	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
979982004129	substrate binding site [chemical binding]; other site
979982004130	Predicted transcriptional regulators [Transcription]; Region: COG1695
979982004131	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
979982004132	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
979982004133	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
979982004134	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
979982004135	heterotetramer interface [polypeptide binding]; other site
979982004136	active site pocket [active]
979982004137	cleavage site
979982004138	AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238
979982004139	nucleotide binding site [chemical binding]; other site
979982004140	N-acetyl-L-glutamate binding site [chemical binding]; other site
979982004141	acetylornithine aminotransferase; Provisional; Region: argD; PRK02936
979982004142	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
979982004143	inhibitor-cofactor binding pocket; inhibition site
979982004144	pyridoxal 5'-phosphate binding site [chemical binding]; other site
979982004145	catalytic residue [active]
979982004146	ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209
979982004147	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
979982004148	S-adenosylmethionine binding site [chemical binding]; other site
979982004149	O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK03640
979982004150	O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912
979982004151	acyl-activating enzyme (AAE) consensus motif; other site
979982004152	putative AMP binding site [chemical binding]; other site
979982004153	putative active site [active]
979982004154	putative CoA binding site [chemical binding]; other site
979982004155	copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698
979982004156	Penicillinase repressor; Region: Pencillinase_R; pfam03965
979982004157	copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511
979982004158	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
979982004159	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
979982004160	fructuronate transporter; Provisional; Region: PRK10034; cl15264
979982004161	GntP family permease; Region: GntP_permease; pfam02447
979982004162	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
979982004163	amphipathic channel; other site
979982004164	Asn-Pro-Ala signature motifs; other site
979982004165	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
979982004166	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
979982004167	active site
979982004168	Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105
979982004169	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
979982004170	DNA binding residues [nucleotide binding]
979982004171	putative dimer interface [polypeptide binding]; other site
979982004172	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
979982004173	Sulfatase; Region: Sulfatase; pfam00884
979982004174	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
979982004175	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
979982004176	Coenzyme A binding pocket [chemical binding]; other site
979982004177	4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337
979982004178	Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647
979982004179	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
979982004180	active site
979982004181	motif I; other site
979982004182	motif II; other site
979982004183	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
979982004184	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
979982004185	Major Facilitator Superfamily; Region: MFS_1; pfam07690
979982004186	putative substrate translocation pore; other site
979982004187	potential protein location (hypothetical protein LGMK_06320 [Leuconostoc sp. C2]) that overlaps RNA (tRNA-A)
979982004188	Predicted RNA binding protein (contains ribosomal protein S1 domain) [Translation, ribosomal structure and biogenesis]; Region: VacB; COG1098
979982004189	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
979982004190	RNA binding site [nucleotide binding]; other site
979982004191	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197
979982004192	active site
979982004193	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
979982004194	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
979982004195	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
979982004196	catalytic site [active]
979982004197	G-X2-G-X-G-K; other site
979982004198	Bacterial protein of unknown function (DUF948); Region: DUF948; pfam06103
979982004199	phosphodiesterase; Provisional; Region: PRK12704
979982004200	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
979982004201	Zn2+ binding site [ion binding]; other site
979982004202	Mg2+ binding site [ion binding]; other site
979982004203	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
979982004204	SmpB-tmRNA interface; other site
979982004205	ribonuclease R; Region: RNase_R; TIGR02063
979982004206	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
979982004207	RNB domain; Region: RNB; pfam00773
979982004208	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
979982004209	RNA binding site [nucleotide binding]; other site
979982004210	Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314
979982004211	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
979982004212	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
979982004213	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
979982004214	OxaA-like protein precursor; Provisional; Region: PRK02463
979982004215	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
979982004216	Acylphosphatase; Region: Acylphosphatase; pfam00708
979982004217	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
979982004218	HAMP domain; Region: HAMP; pfam00672
979982004219	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
979982004220	dimer interface [polypeptide binding]; other site
979982004221	phosphorylation site [posttranslational modification]
979982004222	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
979982004223	ATP binding site [chemical binding]; other site
979982004224	Mg2+ binding site [ion binding]; other site
979982004225	G-X-G motif; other site
979982004226	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
979982004227	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
979982004228	active site
979982004229	phosphorylation site [posttranslational modification]
979982004230	intermolecular recognition site; other site
979982004231	dimerization interface [polypeptide binding]; other site
979982004232	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
979982004233	DNA binding site [nucleotide binding]
979982004234	Uncharacterized ACR, COG1399; Region: DUF177; cl00616
979982004235	HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673
979982004236	hypothetical protein; Provisional; Region: PRK13670
979982004237	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
979982004238	iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090
979982004239	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
979982004240	Zn2+ binding site [ion binding]; other site
979982004241	Mg2+ binding site [ion binding]; other site
979982004242	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
979982004243	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
979982004244	active site
979982004245	(T/H)XGH motif; other site
979982004246	Escherichia coli YhbY is associated with pre-50S ribosomal subunits, which implies a function in ribosome assembly; Region: CRS1_YhbY; smart01103
979982004247	GTPase YqeH; Provisional; Region: PRK13796
979982004248	Circularly permuted YqeH GTPase; Region: YqeH; cd01855
979982004249	GTP/Mg2+ binding site [chemical binding]; other site
979982004250	G4 box; other site
979982004251	G5 box; other site
979982004252	G1 box; other site
979982004253	Switch I region; other site
979982004254	G2 box; other site
979982004255	G3 box; other site
979982004256	Switch II region; other site
979982004257	Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179
979982004258	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
979982004259	active site
979982004260	motif I; other site
979982004261	motif II; other site
979982004262	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
979982004263	potential frameshift: common BLAST hit: gi|300174118|ref|YP_003773284.1| transposase
979982004264	Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641
979982004265	Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303
979982004266	D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186
979982004267	D-lactate dehydrogenase; Validated; Region: PRK08605
979982004268	homodimer interface [polypeptide binding]; other site
979982004269	ligand binding site [chemical binding]; other site
979982004270	NAD binding site [chemical binding]; other site
979982004271	catalytic site [active]
979982004272	Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740
979982004273	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
979982004274	oligomer interface [polypeptide binding]; other site
979982004275	active site residues [active]
979982004276	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481
979982004277	Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298
979982004278	conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826
979982004279	family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187
979982004280	phosphate binding site [ion binding]; other site
979982004281	putative substrate binding pocket [chemical binding]; other site
979982004282	dimer interface [polypeptide binding]; other site
979982004283	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
979982004284	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
979982004285	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
979982004286	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
979982004287	excinuclease ABC subunit B; Provisional; Region: PRK05298
979982004288	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
979982004289	ATP binding site [chemical binding]; other site
979982004290	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
979982004291	nucleotide binding region [chemical binding]; other site
979982004292	ATP-binding site [chemical binding]; other site
979982004293	Ultra-violet resistance protein B; Region: UvrB; pfam12344
979982004294	UvrB/uvrC motif; Region: UVR; pfam02151
979982004295	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
979982004296	Sulfatase; Region: Sulfatase; pfam00884
979982004297	Protein of unknown function (DUF1797); Region: DUF1797; cl11550
979982004298	Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706
979982004299	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
979982004300	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
979982004301	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
979982004302	This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817
979982004303	putative ADP-binding pocket [chemical binding]; other site
979982004304	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
979982004305	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
979982004306	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
979982004307	Walker A/P-loop; other site
979982004308	ATP binding site [chemical binding]; other site
979982004309	Q-loop/lid; other site
979982004310	ABC transporter signature motif; other site
979982004311	Walker B; other site
979982004312	D-loop; other site
979982004313	H-loop/switch region; other site
979982004314	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
979982004315	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
979982004316	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
979982004317	Walker A/P-loop; other site
979982004318	ATP binding site [chemical binding]; other site
979982004319	Q-loop/lid; other site
979982004320	ABC transporter signature motif; other site
979982004321	Walker B; other site
979982004322	D-loop; other site
979982004323	H-loop/switch region; other site
979982004324	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
979982004325	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
979982004326	Walker A/P-loop; other site
979982004327	ATP binding site [chemical binding]; other site
979982004328	Q-loop/lid; other site
979982004329	ABC transporter signature motif; other site
979982004330	Walker B; other site
979982004331	D-loop; other site
979982004332	H-loop/switch region; other site
979982004333	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
979982004334	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
979982004335	FtsX-like permease family; Region: FtsX; pfam02687
979982004336	potential frameshift: common BLAST hit: gi|300173731|ref|YP_003772897.1| NTP pyrophosphohydrolase
979982004337	HD domain; Region: HD_3; cl17350
979982004338	Preprotein translocase subunit; Region: YajC; cl00806
979982004339	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
979982004340	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
979982004341	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
979982004342	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
979982004343	DNA binding residues [nucleotide binding]
979982004344	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
979982004345	MPN+ (JAMM) motif; other site
979982004346	Zinc-binding site [ion binding]; other site
979982004347	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
979982004348	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
979982004349	putative substrate translocation pore; other site
979982004350	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
979982004351	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
979982004352	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
979982004353	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
979982004354	DEAD-like helicases superfamily; Region: DEXDc; smart00487
979982004355	ATP binding site [chemical binding]; other site
979982004356	Mg++ binding site [ion binding]; other site
979982004357	motif III; other site
979982004358	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
979982004359	nucleotide binding region [chemical binding]; other site
979982004360	ATP-binding site [chemical binding]; other site
979982004361	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
979982004362	Beta-lactamase; Region: Beta-lactamase; pfam00144
979982004363	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
979982004364	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
979982004365	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
979982004366	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
979982004367	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
979982004368	S-adenosylmethionine binding site [chemical binding]; other site
979982004369	50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678
979982004370	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
979982004371	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
979982004372	hinge; other site
979982004373	active site
979982004374	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
979982004375	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
979982004376	putative tRNA-binding site [nucleotide binding]; other site
979982004377	B3/4 domain; Region: B3_4; pfam03483
979982004378	tRNA synthetase B5 domain; Region: B5; smart00874
979982004379	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
979982004380	dimer interface [polypeptide binding]; other site
979982004381	motif 1; other site
979982004382	motif 3; other site
979982004383	motif 2; other site
979982004384	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
979982004385	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
979982004386	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
979982004387	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
979982004388	dimer interface [polypeptide binding]; other site
979982004389	motif 1; other site
979982004390	active site
979982004391	motif 2; other site
979982004392	motif 3; other site
979982004393	Predicted transcriptional regulators [Transcription]; Region: COG1733
979982004394	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
979982004395	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
979982004396	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
979982004397	nucleotide binding site [chemical binding]; other site
979982004398	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
979982004399	active site
979982004400	metal binding site [ion binding]; metal-binding site
979982004401	L-threonine dehydrogenase; Region: threonine_DH_like; cd08234
979982004402	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
979982004403	putative NAD(P) binding site [chemical binding]; other site
979982004404	catalytic Zn binding site [ion binding]; other site
979982004405	Transcriptional regulators [Transcription]; Region: PurR; COG1609
979982004406	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
979982004407	DNA binding site [nucleotide binding]
979982004408	domain linker motif; other site
979982004409	Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291
979982004410	dimerization interface [polypeptide binding]; other site
979982004411	ligand binding site [chemical binding]; other site
979982004412	sodium binding site [ion binding]; other site
979982004413	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
979982004414	Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_2; cd12172
979982004415	putative ligand binding site [chemical binding]; other site
979982004416	putative NAD binding site [chemical binding]; other site
979982004417	catalytic site [active]
979982004418	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
979982004419	active site
979982004420	catalytic motif [active]
979982004421	Zn binding site [ion binding]; other site
979982004422	oligoendopeptidase F; Region: pepF; TIGR00181
979982004423	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608
979982004424	active site
979982004425	Zn binding site [ion binding]; other site
979982004426	Competence protein CoiA-like family; Region: CoiA; cl11541
979982004427	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
979982004428	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
979982004429	substrate binding pocket [chemical binding]; other site
979982004430	membrane-bound complex binding site; other site
979982004431	hinge residues; other site
979982004432	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
979982004433	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
979982004434	dimer interface [polypeptide binding]; other site
979982004435	conserved gate region; other site
979982004436	putative PBP binding loops; other site
979982004437	ABC-ATPase subunit interface; other site
979982004438	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
979982004439	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
979982004440	Walker A/P-loop; other site
979982004441	ATP binding site [chemical binding]; other site
979982004442	Q-loop/lid; other site
979982004443	ABC transporter signature motif; other site
979982004444	Walker B; other site
979982004445	D-loop; other site
979982004446	H-loop/switch region; other site
979982004447	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
979982004448	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
979982004449	substrate binding pocket [chemical binding]; other site
979982004450	membrane-bound complex binding site; other site
979982004451	hinge residues; other site
979982004452	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
979982004453	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
979982004454	dimer interface [polypeptide binding]; other site
979982004455	conserved gate region; other site
979982004456	putative PBP binding loops; other site
979982004457	ABC-ATPase subunit interface; other site
979982004458	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
979982004459	Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354
979982004460	ligand binding site [chemical binding]; other site
979982004461	beta-1,6-galactofuranosyltransferase; Provisional; Region: PRK09814
979982004462	Protein of unknown function (DUF2185); Region: DUF2185; cl02019
979982004463	YibE/F-like protein; Region: YibE_F; pfam07907
979982004464	YibE/F-like protein; Region: YibE_F; pfam07907
979982004465	primosomal protein DnaI; Reviewed; Region: PRK08939
979982004466	Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319
979982004467	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
979982004468	Walker A motif; other site
979982004469	ATP binding site [chemical binding]; other site
979982004470	Walker B motif; other site
979982004471	arginine finger; other site
979982004472	Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611
979982004473	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
979982004474	dephospho-CoA kinase; Region: TIGR00152
979982004475	CoA-binding site [chemical binding]; other site
979982004476	ATP-binding [chemical binding]; other site
979982004477	Protein of unknown function (DUF975); Region: DUF975; cl10504
979982004478	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
979982004479	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
979982004480	DNA binding site [nucleotide binding]
979982004481	catalytic residue [active]
979982004482	H2TH interface [polypeptide binding]; other site
979982004483	putative catalytic residues [active]
979982004484	turnover-facilitating residue; other site
979982004485	intercalation triad [nucleotide binding]; other site
979982004486	8OG recognition residue [nucleotide binding]; other site
979982004487	putative reading head residues; other site
979982004488	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
979982004489	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
979982004490	recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409
979982004491	MutS domain III; Region: MutS_III; pfam05192
979982004492	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
979982004493	Walker A/P-loop; other site
979982004494	ATP binding site [chemical binding]; other site
979982004495	Q-loop/lid; other site
979982004496	ABC transporter signature motif; other site
979982004497	Walker B; other site
979982004498	D-loop; other site
979982004499	H-loop/switch region; other site
979982004500	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
979982004501	Smr domain; Region: Smr; pfam01713
979982004502	Colicin V production protein; Region: Colicin_V; pfam02674
979982004503	ribonuclease HIII; Provisional; Region: PRK00996
979982004504	Domain of unknown function (DUF3378); Region: DUF3378; pfam11858
979982004505	bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590
979982004506	RNA/DNA hybrid binding site [nucleotide binding]; other site
979982004507	active site
979982004508	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
979982004509	NAD(P) binding site [chemical binding]; other site
979982004510	Protein of unknown function (DUF3923); Region: DUF3923; pfam13061
979982004511	TspO/MBR family; Region: TspO_MBR; pfam03073
979982004512	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
979982004513	amidase catalytic site [active]
979982004514	Zn binding residues [ion binding]; other site
979982004515	substrate binding site [chemical binding]; other site
979982004516	Prophage endopeptidase tail; Region: Prophage_tail; cl12123
979982004517	Phage-related protein [Function unknown]; Region: COG4722
979982004518	Phage tail protein; Region: Sipho_tail; cl17486
979982004519	tape measure domain; Region: tape_meas_nterm; TIGR02675
979982004520	Phage-related protein [Function unknown]; Region: COG5412
979982004521	membrane protein P6; Region: PHA01399
979982004522	Phage protein; Region: DUF3647; pfam12363
979982004523	Phage major tail protein 2; Region: Phage_tail_2; cl11463
979982004524	Protein of unknown function (DUF3168); Region: DUF3168; pfam11367
979982004525	Bacteriophage protein of unknown function (DUF646); Region: DUF646; pfam04883
979982004526	Phage gp6-like head-tail connector protein; Region: Phage_connect_1; pfam05135
979982004527	Phage capsid family; Region: Phage_capsid; pfam05065
979982004528	Domain of unknown function (DUF4355); Region: DUF4355; pfam14265
979982004529	Lamina-associated polypeptide 1C (LAP1C); Region: LAP1C; pfam05609
979982004530	Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072
979982004531	Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133
979982004532	phage portal protein, SPP1 family; Region: portal_SPP1; TIGR01538
979982004533	Phage terminase large subunit; Region: Terminase_3; cl12054
979982004534	Terminase-like family; Region: Terminase_6; pfam03237
979982004535	Homeodomain-like domain; Region: HTH_23; pfam13384
979982004536	Terminase small subunit; Region: Terminase_2; cl01513
979982004537	Protein of unknown function (DUF722); Region: DUF722; pfam05263
979982004538	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
979982004539	DNA methylase; Region: N6_N4_Mtase; pfam01555
979982004540	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
979982004541	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264
979982004542	Endodeoxyribonuclease RusA; Region: RusA; pfam05866
979982004543	Protein of unknown function (DUF968); Region: DUF968; pfam06147
979982004544	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
979982004545	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
979982004546	dimer interface [polypeptide binding]; other site
979982004547	ssDNA binding site [nucleotide binding]; other site
979982004548	tetramer (dimer of dimers) interface [polypeptide binding]; other site
979982004549	ERF superfamily; Region: ERF; pfam04404
979982004550	Protein of unknown function (DUF1351); Region: DUF1351; pfam07083
979982004551	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
979982004552	Walker A motif; other site
979982004553	ATP binding site [chemical binding]; other site
979982004554	Walker B motif; other site
979982004555	Conserved phage C-terminus (Phg_2220_C); Region: Phg_2220_C; pfam09524
979982004556	Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523
979982004557	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
979982004558	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
979982004559	non-specific DNA binding site [nucleotide binding]; other site
979982004560	salt bridge; other site
979982004561	sequence-specific DNA binding site [nucleotide binding]; other site
979982004562	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
979982004563	Int/Topo IB signature motif; other site
979982004564	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
979982004565	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
979982004566	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
979982004567	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
979982004568	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
979982004569	ATP-grasp domain; Region: ATP-grasp_4; cl17255
979982004570	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
979982004571	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
979982004572	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
979982004573	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
979982004574	carboxyltransferase (CT) interaction site; other site
979982004575	biotinylation site [posttranslational modification]; other site
979982004576	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
979982004577	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
979982004578	dimer interface [polypeptide binding]; other site
979982004579	active site
979982004580	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
979982004581	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
979982004582	NAD(P) binding site [chemical binding]; other site
979982004583	homotetramer interface [polypeptide binding]; other site
979982004584	homodimer interface [polypeptide binding]; other site
979982004585	active site
979982004586	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
979982004587	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
979982004588	putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151
979982004589	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
979982004590	FMN binding site [chemical binding]; other site
979982004591	substrate binding site [chemical binding]; other site
979982004592	putative catalytic residue [active]
979982004593	acyl carrier protein; Provisional; Region: acpP; PRK00982
979982004594	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
979982004595	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
979982004596	dimer interface [polypeptide binding]; other site
979982004597	active site
979982004598	CoA binding pocket [chemical binding]; other site
979982004599	MarR family; Region: MarR_2; pfam12802
979982004600	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
979982004601	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
979982004602	putative phosphoesterase; Region: acc_ester; TIGR03729
979982004603	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
979982004604	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
979982004605	glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534
979982004606	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
979982004607	AAA domain; Region: AAA_26; pfam13500
979982004608	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
979982004609	adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK06916
979982004610	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
979982004611	inhibitor-cofactor binding pocket; inhibition site
979982004612	pyridoxal 5'-phosphate binding site [chemical binding]; other site
979982004613	catalytic residue [active]
979982004614	Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268
979982004615	Biotin operon repressor [Transcription]; Region: BirA; COG1654
979982004616	bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886
979982004617	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
979982004618	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
979982004619	methionyl-tRNA synthetase; Reviewed; Region: PRK12267
979982004620	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
979982004621	active site
979982004622	HIGH motif; other site
979982004623	KMSKS motif; other site
979982004624	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
979982004625	tRNA binding surface [nucleotide binding]; other site
979982004626	anticodon binding site; other site
979982004627	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
979982004628	dimer interface [polypeptide binding]; other site
979982004629	putative tRNA-binding site [nucleotide binding]; other site
979982004630	Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418
979982004631	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
979982004632	Zn2+ binding site [ion binding]; other site
979982004633	Mg2+ binding site [ion binding]; other site
979982004634	DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; cl17626
979982004635	Predicted membrane protein [Function unknown]; Region: COG4640
979982004636	SEC10/PgrA surface exclusion domain; Region: Surf_Exclu_PgrA; TIGR04320
979982004637	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
979982004638	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
979982004639	NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650
979982004640	active site
979982004641	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
979982004642	catalytic core [active]
979982004643	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
979982004644	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
979982004645	putative catalytic cysteine [active]
979982004646	Glutamate 5-kinase [Amino acid transport and metabolism]; Region: ProB; COG0263
979982004647	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
979982004648	nucleotide binding site [chemical binding]; other site
979982004649	homotetrameric interface [polypeptide binding]; other site
979982004650	putative phosphate binding site [ion binding]; other site
979982004651	putative allosteric binding site; other site
979982004652	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
979982004653	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
979982004654	oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290
979982004655	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_2; cd09607
979982004656	active site
979982004657	Zn binding site [ion binding]; other site
979982004658	Predicted membrane protein [Function unknown]; Region: COG2035
979982004659	Uncharacterized conserved protein [Function unknown]; Region: COG0398
979982004660	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
979982004661	Domain of unknown function (DUF4097); Region: DUF4097; pfam13349
979982004662	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
979982004663	Protein of unknown function (DUF1700); Region: DUF1700; pfam08006
979982004664	Predicted transcriptional regulators [Transcription]; Region: COG1695
979982004665	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
979982004666	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
979982004667	thiamine phosphate binding site [chemical binding]; other site
979982004668	active site
979982004669	pyrophosphate binding site [ion binding]; other site
979982004670	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
979982004671	dimer interface [polypeptide binding]; other site
979982004672	substrate binding site [chemical binding]; other site
979982004673	ATP binding site [chemical binding]; other site
979982004674	4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170
979982004675	substrate binding site [chemical binding]; other site
979982004676	multimerization interface [polypeptide binding]; other site
979982004677	ATP binding site [chemical binding]; other site
979982004678	Thiamine-precursor transporter protein (ThiW); Region: ThiW; cl01952
979982004679	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3864
979982004680	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
979982004681	metal ion-dependent adhesion site (MIDAS); other site
979982004682	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
979982004683	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
979982004684	Walker A motif; other site
979982004685	ATP binding site [chemical binding]; other site
979982004686	Walker B motif; other site
979982004687	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
979982004688	NADH(P)-binding; Region: NAD_binding_10; pfam13460
979982004689	NAD(P) binding site [chemical binding]; other site
979982004690	active site
979982004691	Dyp-type peroxidase family; Region: Dyp_perox; cl01067
979982004692	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
979982004693	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
979982004694	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
979982004695	Bacterial membrane protein YfhO; Region: YfhO; pfam09586
979982004696	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
979982004697	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
979982004698	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
979982004699	Sugar transport protein; Region: Sugar_transport; pfam06800
979982004700	proteins similar to Escherichia coli yceG; Region: yceG_like; cl17666
979982004701	dimerization interface [polypeptide binding]; other site
979982004702	Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705
979982004703	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
979982004704	propionate/acetate kinase; Provisional; Region: PRK12379
979982004705	Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827
979982004706	Methyltransferase domain; Region: Methyltransf_26; pfam13659
979982004707	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
979982004708	Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537
979982004709	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
979982004710	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
979982004711	Type II/IV secretion system protein; Region: T2SE; pfam00437
979982004712	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
979982004713	Walker A motif; other site
979982004714	ATP binding site [chemical binding]; other site
979982004715	Walker B motif; other site
979982004716	glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097
979982004717	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
979982004718	active site
979982004719	dimer interface [polypeptide binding]; other site
979982004720	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
979982004721	dimer interface [polypeptide binding]; other site
979982004722	active site
979982004723	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
979982004724	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
979982004725	active site
979982004726	trimer interface [polypeptide binding]; other site
979982004727	allosteric site; other site
979982004728	active site lid [active]
979982004729	hexamer (dimer of trimers) interface [polypeptide binding]; other site
979982004730	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
979982004731	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
979982004732	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
979982004733	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
979982004734	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
979982004735	dimer interface [polypeptide binding]; other site
979982004736	phosphorylation site [posttranslational modification]
979982004737	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
979982004738	ATP binding site [chemical binding]; other site
979982004739	Mg2+ binding site [ion binding]; other site
979982004740	G-X-G motif; other site
979982004741	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
979982004742	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
979982004743	active site
979982004744	phosphorylation site [posttranslational modification]
979982004745	intermolecular recognition site; other site
979982004746	dimerization interface [polypeptide binding]; other site
979982004747	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
979982004748	DNA binding site [nucleotide binding]
979982004749	Protein of unknown function (DUF1129); Region: DUF1129; pfam06570
979982004750	GTP-binding protein YchF; Reviewed; Region: PRK09601
979982004751	YchF GTPase; Region: YchF; cd01900
979982004752	G1 box; other site
979982004753	GTP/Mg2+ binding site [chemical binding]; other site
979982004754	Switch I region; other site
979982004755	G2 box; other site
979982004756	Switch II region; other site
979982004757	G3 box; other site
979982004758	G4 box; other site
979982004759	G5 box; other site
979982004760	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
979982004761	Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107
979982004762	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
979982004763	ParB-like nuclease domain; Region: ParB; smart00470
979982004764	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
979982004765	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
979982004766	P-loop; other site
979982004767	Magnesium ion binding site [ion binding]; other site
979982004768	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
979982004769	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
979982004770	S-adenosylmethionine binding site [chemical binding]; other site
979982004771	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
979982004772	dimerization interface [polypeptide binding]; other site
979982004773	putative DNA binding site [nucleotide binding]; other site
979982004774	putative Zn2+ binding site [ion binding]; other site
979982004775	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
979982004776	Ligand Binding Site [chemical binding]; other site
979982004777	manganese transport protein MntH; Reviewed; Region: PRK00701
979982004778	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
979982004779	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
979982004780	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
979982004781	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
979982004782	Metal binding protein PsaA.  These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137
979982004783	metal binding site [ion binding]; metal-binding site
979982004784	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
979982004785	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
979982004786	ABC-ATPase subunit  interface; other site
979982004787	dimer interface [polypeptide binding]; other site
979982004788	putative PBP binding regions; other site
979982004789	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
979982004790	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
979982004791	NAD-dependent deacetylase; Provisional; Region: PRK00481
979982004792	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
979982004793	Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644
979982004794	homodimer interface [polypeptide binding]; other site
979982004795	catalytic residues [active]
979982004796	NAD binding site [chemical binding]; other site
979982004797	substrate binding pocket [chemical binding]; other site
979982004798	flexible flap; other site
979982004799	exopolyphosphatase; Region: exo_poly_only; TIGR03706
979982004800	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
979982004801	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832
979982004802	PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396
979982004803	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
979982004804	active site
979982004805	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581
979982004806	FemAB family; Region: FemAB; pfam02388
979982004807	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
979982004808	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
979982004809	NlpC/P60 family; Region: NLPC_P60; cl17555
979982004810	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
979982004811	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
979982004812	SCP: SCP-like extracellular protein domain, found in eukaryotes and prokaryotes. This family includes plant pathogenesis-related protein 1 (PR-1), which accumulates after infections with pathogens, and may act as an anti-fungal agent or be involved in...; Region: SCP; cl00133
979982004813	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
979982004814	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
979982004815	dimer interface [polypeptide binding]; other site
979982004816	active site
979982004817	CoA binding pocket [chemical binding]; other site
979982004818	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
979982004819	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
979982004820	active site
979982004821	HIGH motif; other site
979982004822	nucleotide binding site [chemical binding]; other site
979982004823	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
979982004824	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
979982004825	active site
979982004826	KMSKS motif; other site
979982004827	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
979982004828	tRNA binding surface [nucleotide binding]; other site
979982004829	anticodon binding site; other site
979982004830	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
979982004831	Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594
979982004832	Acyltransferase family; Region: Acyl_transf_3; pfam01757
979982004833	PemK-like protein; Region: PemK; pfam02452
979982004834	Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787
979982004835	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
979982004836	active site
979982004837	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
979982004838	dimer interface [polypeptide binding]; other site
979982004839	substrate binding site [chemical binding]; other site
979982004840	catalytic residues [active]
979982004841	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
979982004842	potential protein location (hypothetical protein LGMK_07630 [Leuconostoc sp. C2]) that overlaps RNA (tRNA-A)
979982004843	Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641
979982004844	Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303
979982004845	aromatic amino acid aminotransferase; Validated; Region: PRK07309
979982004846	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
979982004847	pyridoxal 5'-phosphate binding site [chemical binding]; other site
979982004848	homodimer interface [polypeptide binding]; other site
979982004849	catalytic residue [active]
979982004850	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
979982004851	active site
979982004852	amino acid transporter; Region: 2A0306; TIGR00909
979982004853	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
979982004854	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
979982004855	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
979982004856	septation ring formation regulator EzrA; Provisional; Region: PRK04778
979982004857	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
979982004858	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
979982004859	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
979982004860	RNA binding surface [nucleotide binding]; other site
979982004861	Protein of unknown function (DUF1694); Region: DUF1694; pfam07997
979982004862	recombination factor protein RarA; Reviewed; Region: PRK13342
979982004863	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
979982004864	Walker A motif; other site
979982004865	ATP binding site [chemical binding]; other site
979982004866	Walker B motif; other site
979982004867	arginine finger; other site
979982004868	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
979982004869	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
979982004870	Ligand Binding Site [chemical binding]; other site
979982004871	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
979982004872	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
979982004873	non-specific DNA binding site [nucleotide binding]; other site
979982004874	salt bridge; other site
979982004875	sequence-specific DNA binding site [nucleotide binding]; other site
979982004876	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
979982004877	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
979982004878	D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478
979982004879	Protein of unknown function (DUF2785); Region: DUF2785; pfam10978
979982004880	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
979982004881	Protein of unknown function (DUF2969); Region: DUF2969; pfam11184
979982004882	rod shape-determining protein MreB; Provisional; Region: PRK13930
979982004883	MreB and similar proteins; Region: MreB_like; cd10225
979982004884	nucleotide binding site [chemical binding]; other site
979982004885	Mg binding site [ion binding]; other site
979982004886	putative protofilament interaction site [polypeptide binding]; other site
979982004887	RodZ interaction site [polypeptide binding]; other site
979982004888	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
979982004889	substrate binding site [chemical binding]; other site
979982004890	THF binding site; other site
979982004891	zinc-binding site [ion binding]; other site
979982004892	Protein of unknown function (DUF1146); Region: DUF1146; cl11486
979982004893	DNA topoisomerase I; Validated; Region: PRK05582
979982004894	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
979982004895	active site
979982004896	interdomain interaction site; other site
979982004897	putative metal-binding site [ion binding]; other site
979982004898	nucleotide binding site [chemical binding]; other site
979982004899	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
979982004900	domain I; other site
979982004901	DNA binding groove [nucleotide binding]
979982004902	phosphate binding site [ion binding]; other site
979982004903	domain II; other site
979982004904	domain III; other site
979982004905	nucleotide binding site [chemical binding]; other site
979982004906	catalytic site [active]
979982004907	domain IV; other site
979982004908	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
979982004909	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
979982004910	lysine transporter; Provisional; Region: PRK10836
979982004911	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581
979982004912	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
979982004913	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
979982004914	active site
979982004915	HIGH motif; other site
979982004916	dimer interface [polypeptide binding]; other site
979982004917	KMSKS motif; other site
979982004918	Ketopantoate reductase [Coenzyme metabolism]; Region: ApbA; COG1893
979982004919	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
979982004920	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
979982004921	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
979982004922	nudix motif; other site
979982004923	Protein of unknown function (DUF1810); Region: DUF1810; cl02370
979982004924	37-kD nucleoid-associated bacterial protein; Region: NA37; cl15473
979982004925	Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565
979982004926	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
979982004927	active site
979982004928	phosphorylation site [posttranslational modification]
979982004929	intermolecular recognition site; other site
979982004930	dimerization interface [polypeptide binding]; other site
979982004931	sensory histidine kinase DcuS; Provisional; Region: PRK11086
979982004932	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
979982004933	ATP binding site [chemical binding]; other site
979982004934	Mg2+ binding site [ion binding]; other site
979982004935	G-X-G motif; other site
979982004936	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
979982004937	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
979982004938	NAD binding site [chemical binding]; other site
979982004939	Membrane transport protein; Region: Mem_trans; cl09117
979982004940	beta-phosphoglucomutase; Region: bPGM; TIGR01990
979982004941	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
979982004942	motif II; other site
979982004943	Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554
979982004944	Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636
979982004945	Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632
979982004946	Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633
979982004947	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162
979982004948	glycerol kinase (GK) interaction site [polypeptide binding]; other site
979982004949	active site
979982004950	HPr interaction site; other site
979982004951	phosphorylation site [posttranslational modification]
979982004952	PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996
979982004953	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
979982004954	active site turn [active]
979982004955	phosphorylation site [posttranslational modification]
979982004956	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
979982004957	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162
979982004958	trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404
979982004959	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
979982004960	DNA-binding site [nucleotide binding]; DNA binding site
979982004961	UTRA domain; Region: UTRA; pfam07702
979982004962	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
979982004963	ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464
979982004964	Walker A motif; other site
979982004965	ATP binding site [chemical binding]; other site
979982004966	Walker B motif; other site
979982004967	arginine finger; other site
979982004968	UvrB/uvrC motif; Region: UVR; pfam02151
979982004969	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
979982004970	Walker A motif; other site
979982004971	ATP binding site [chemical binding]; other site
979982004972	Walker B motif; other site
979982004973	arginine finger; other site
979982004974	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
979982004975	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
979982004976	TRAM domain; Region: TRAM; pfam01938
979982004977	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
979982004978	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
979982004979	S-adenosylmethionine binding site [chemical binding]; other site
979982004980	hypothetical protein; Validated; Region: PRK07668
979982004981	Predicted transcriptional regulators [Transcription]; Region: COG1695
979982004982	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
979982004983	Domain of unknown function DUF20; Region: UPF0118; pfam01594
979982004984	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
979982004985	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
979982004986	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
979982004987	minor groove reading motif; other site
979982004988	helix-hairpin-helix signature motif; other site
979982004989	substrate binding pocket [chemical binding]; other site
979982004990	active site
979982004991	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
979982004992	DNA binding and oxoG recognition site [nucleotide binding]
979982004993	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
979982004994	Major Facilitator Superfamily; Region: MFS_1; pfam07690
979982004995	putative substrate translocation pore; other site
979982004996	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
979982004997	dimer interface [polypeptide binding]; other site
979982004998	substrate binding site [chemical binding]; other site
979982004999	ATP binding site [chemical binding]; other site
979982005000	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
979982005001	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
979982005002	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
979982005003	protein binding site [polypeptide binding]; other site
979982005004	YycH protein; Region: YycI; cl02015
979982005005	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863
979982005006	YycH protein; Region: YycH; pfam07435
979982005007	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002
979982005008	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
979982005009	dimerization interface [polypeptide binding]; other site
979982005010	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
979982005011	putative active site [active]
979982005012	heme pocket [chemical binding]; other site
979982005013	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
979982005014	dimer interface [polypeptide binding]; other site
979982005015	phosphorylation site [posttranslational modification]
979982005016	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
979982005017	ATP binding site [chemical binding]; other site
979982005018	Mg2+ binding site [ion binding]; other site
979982005019	G-X-G motif; other site
979982005020	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
979982005021	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
979982005022	active site
979982005023	phosphorylation site [posttranslational modification]
979982005024	intermolecular recognition site; other site
979982005025	dimerization interface [polypeptide binding]; other site
979982005026	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
979982005027	DNA binding site [nucleotide binding]
979982005028	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
979982005029	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
979982005030	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
979982005031	active site
979982005032	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
979982005033	dimer interface [polypeptide binding]; other site
979982005034	catalytic triad [active]
979982005035	peroxidatic and resolving cysteines [active]
979982005036	sugar phosphate phosphatase; Provisional; Region: PRK10513
979982005037	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
979982005038	active site
979982005039	motif I; other site
979982005040	motif II; other site
979982005041	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
979982005042	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
979982005043	Major Facilitator Superfamily; Region: MFS_1; pfam07690
979982005044	putative substrate translocation pore; other site
979982005045	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
979982005046	nudix motif; other site
979982005047	putative phosphoketolase; Provisional; Region: PRK05261
979982005048	XFP N-terminal domain; Region: XFP_N; pfam09364
979982005049	XFP C-terminal domain; Region: XFP_C; pfam09363
979982005050	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
979982005051	C factor cell-cell signaling protein; Provisional; Region: PRK09009
979982005052	NAD(P) binding site [chemical binding]; other site
979982005053	active site
979982005054	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
979982005055	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
979982005056	non-specific DNA binding site [nucleotide binding]; other site
979982005057	salt bridge; other site
979982005058	sequence-specific DNA binding site [nucleotide binding]; other site
979982005059	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
979982005060	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
979982005061	DNA-binding site [nucleotide binding]; DNA binding site
979982005062	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
979982005063	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
979982005064	putative deacylase active site [active]
979982005065	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
979982005066	homotrimer interaction site [polypeptide binding]; other site
979982005067	putative active site [active]
979982005068	replicative DNA helicase; Region: DnaB; TIGR00665
979982005069	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
979982005070	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
979982005071	Walker A motif; other site
979982005072	ATP binding site [chemical binding]; other site
979982005073	Walker B motif; other site
979982005074	DNA binding loops [nucleotide binding]
979982005075	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
979982005076	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
979982005077	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
979982005078	Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887
979982005079	Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967
979982005080	DHH family; Region: DHH; pfam01368
979982005081	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
979982005082	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
979982005083	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
979982005084	dimer interface [polypeptide binding]; other site
979982005085	ssDNA binding site [nucleotide binding]; other site
979982005086	tetramer (dimer of dimers) interface [polypeptide binding]; other site
979982005087	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
979982005088	dipeptidase PepV; Reviewed; Region: PRK07318
979982005089	M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888
979982005090	active site
979982005091	metal binding site [ion binding]; metal-binding site
979982005092	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
979982005093	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
979982005094	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
979982005095	Walker A/P-loop; other site
979982005096	ATP binding site [chemical binding]; other site
979982005097	Q-loop/lid; other site
979982005098	ABC transporter signature motif; other site
979982005099	Walker B; other site
979982005100	D-loop; other site
979982005101	H-loop/switch region; other site
979982005102	ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558
979982005103	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
979982005104	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
979982005105	Walker A/P-loop; other site
979982005106	ATP binding site [chemical binding]; other site
979982005107	Q-loop/lid; other site
979982005108	ABC transporter signature motif; other site
979982005109	Walker B; other site
979982005110	D-loop; other site
979982005111	H-loop/switch region; other site
979982005112	hypothetical protein; Provisional; Region: PRK13661
979982005113	Uncharacterized conserved protein [Function unknown]; Region: COG1912
979982005114	putative metalloenzyme radical SAM/SPASM domain maturase; Region: rSAM_Geo_metal; TIGR04311
979982005115	ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422
979982005116	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297
979982005117	NAD binding site [chemical binding]; other site
979982005118	substrate binding site [chemical binding]; other site
979982005119	catalytic Zn binding site [ion binding]; other site
979982005120	tetramer interface [polypeptide binding]; other site
979982005121	structural Zn binding site [ion binding]; other site
979982005122	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
979982005123	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
979982005124	putative NAD(P) binding site [chemical binding]; other site
979982005125	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
979982005126	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
979982005127	active site
979982005128	HIGH motif; other site
979982005129	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
979982005130	active site
979982005131	KMSKS motif; other site
979982005132	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
979982005133	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
979982005134	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
979982005135	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
979982005136	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
979982005137	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
979982005138	active site
979982005139	phosphorylation site [posttranslational modification]
979982005140	intermolecular recognition site; other site
979982005141	dimerization interface [polypeptide binding]; other site
979982005142	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
979982005143	DNA binding residues [nucleotide binding]
979982005144	dimerization interface [polypeptide binding]; other site
979982005145	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
979982005146	Histidine kinase; Region: HisKA_3; pfam07730
979982005147	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
979982005148	ATP binding site [chemical binding]; other site
979982005149	Mg2+ binding site [ion binding]; other site
979982005150	G-X-G motif; other site
979982005151	MMPL family; Region: MMPL; pfam03176
979982005152	Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033
979982005153	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
979982005154	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
979982005155	non-specific DNA binding site [nucleotide binding]; other site
979982005156	salt bridge; other site
979982005157	sequence-specific DNA binding site [nucleotide binding]; other site
979982005158	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
979982005159	DNA repair protein RadA; Provisional; Region: PRK11823
979982005160	Walker A motif/ATP binding site; other site
979982005161	ATP binding site [chemical binding]; other site
979982005162	Walker B motif; other site
979982005163	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
979982005164	Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850
979982005165	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
979982005166	active site
979982005167	metal binding site [ion binding]; metal-binding site
979982005168	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
979982005169	nudix motif; other site
979982005170	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
979982005171	trimer interface [polypeptide binding]; other site
979982005172	active site
979982005173	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
979982005174	Coenzyme A binding pocket [chemical binding]; other site
979982005175	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
979982005176	tetramer (dimer of dimers) interface [polypeptide binding]; other site
979982005177	active site
979982005178	dimer interface [polypeptide binding]; other site
979982005179	aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273
979982005180	Aspartase; Region: Aspartase; cd01357
979982005181	active sites [active]
979982005182	tetramer interface [polypeptide binding]; other site
979982005183	Bacterial membrane protein YfhO; Region: YfhO; pfam09586
979982005184	Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590
979982005185	Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662
979982005186	active site
979982005187	Zn binding site [ion binding]; other site
979982005188	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
979982005189	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
979982005190	Walker A/P-loop; other site
979982005191	ATP binding site [chemical binding]; other site
979982005192	Q-loop/lid; other site
979982005193	ABC transporter signature motif; other site
979982005194	Walker B; other site
979982005195	D-loop; other site
979982005196	H-loop/switch region; other site
979982005197	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
979982005198	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
979982005199	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
979982005200	Walker A/P-loop; other site
979982005201	ATP binding site [chemical binding]; other site
979982005202	Q-loop/lid; other site
979982005203	ABC transporter signature motif; other site
979982005204	Walker B; other site
979982005205	D-loop; other site
979982005206	H-loop/switch region; other site
979982005207	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
979982005208	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
979982005209	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
979982005210	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
979982005211	dimer interface [polypeptide binding]; other site
979982005212	conserved gate region; other site
979982005213	putative PBP binding loops; other site
979982005214	ABC-ATPase subunit interface; other site
979982005215	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
979982005216	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
979982005217	dimer interface [polypeptide binding]; other site
979982005218	conserved gate region; other site
979982005219	putative PBP binding loops; other site
979982005220	ABC-ATPase subunit interface; other site
979982005221	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
979982005222	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
979982005223	peptide binding site [polypeptide binding]; other site
979982005224	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
979982005225	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
979982005226	peptide binding site [polypeptide binding]; other site
979982005227	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
979982005228	dimer interface [polypeptide binding]; other site
979982005229	conserved gate region; other site
979982005230	putative PBP binding loops; other site
979982005231	ABC-ATPase subunit interface; other site
979982005232	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
979982005233	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
979982005234	dimer interface [polypeptide binding]; other site
979982005235	conserved gate region; other site
979982005236	putative PBP binding loops; other site
979982005237	ABC-ATPase subunit interface; other site
979982005238	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
979982005239	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
979982005240	substrate binding pocket [chemical binding]; other site
979982005241	membrane-bound complex binding site; other site
979982005242	hinge residues; other site
979982005243	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
979982005244	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
979982005245	Walker A/P-loop; other site
979982005246	ATP binding site [chemical binding]; other site
979982005247	Q-loop/lid; other site
979982005248	ABC transporter signature motif; other site
979982005249	Walker B; other site
979982005250	D-loop; other site
979982005251	H-loop/switch region; other site
979982005252	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
979982005253	putative active site [active]
979982005254	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
979982005255	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
979982005256	alanine racemase; Reviewed; Region: alr; PRK00053
979982005257	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
979982005258	active site
979982005259	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
979982005260	dimer interface [polypeptide binding]; other site
979982005261	substrate binding site [chemical binding]; other site
979982005262	catalytic residues [active]
979982005263	AAA domain; Region: AAA_17; pfam13207
979982005264	BioY family; Region: BioY; pfam02632
979982005265	Biotin operon repressor [Transcription]; Region: BirA; COG1654
979982005266	bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886
979982005267	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
979982005268	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
979982005269	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
979982005270	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
979982005271	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
979982005272	ABC transporter; Region: ABC_tran_2; pfam12848
979982005273	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
979982005274	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
979982005275	active site
979982005276	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
979982005277	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
979982005278	non-specific DNA binding site [nucleotide binding]; other site
979982005279	salt bridge; other site
979982005280	sequence-specific DNA binding site [nucleotide binding]; other site
979982005281	Putative ClC chloride channel.  Clc proteins are putative halogen ion (Cl-, Br- and I-) transporters found in eubacteria. They belong to the ClC superfamily of halogen ion channels, which share a unique double-barreled architecture and voltage-dependent...; Region: ClC_like; cd01033
979982005282	putative ion selectivity filter; other site
979982005283	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
979982005284	putative pore gating glutamate residue; other site
979982005285	Protein of unknown function (DUF1304); Region: DUF1304; pfam06993
979982005286	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
979982005287	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
979982005288	putative NAD(P) binding site [chemical binding]; other site
979982005289	Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249
979982005290	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
979982005291	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
979982005292	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
979982005293	MarR family; Region: MarR; pfam01047
979982005294	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
979982005295	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
979982005296	nucleotide binding site [chemical binding]; other site
979982005297	Predicted transcriptional regulator [Transcription]; Region: COG1959
979982005298	Transcriptional regulator; Region: Rrf2; pfam02082
979982005299	Transcriptional regulator; Region: Rrf2; cl17282
979982005300	Predicted membrane protein [Function unknown]; Region: COG1511
979982005301	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
979982005302	X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057
979982005303	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
979982005304	bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805
979982005305	Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122
979982005306	putative catalytic cysteine [active]
979982005307	C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178
979982005308	putative active site [active]
979982005309	metal binding site [ion binding]; metal-binding site
979982005310	GtrA-like protein; Region: GtrA; pfam04138
979982005311	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
979982005312	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
979982005313	non-specific DNA binding site [nucleotide binding]; other site
979982005314	salt bridge; other site
979982005315	sequence-specific DNA binding site [nucleotide binding]; other site
979982005316	acetoin reductase; Validated; Region: PRK08643
979982005317	meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366
979982005318	NAD binding site [chemical binding]; other site
979982005319	homotetramer interface [polypeptide binding]; other site
979982005320	homodimer interface [polypeptide binding]; other site
979982005321	active site
979982005322	substrate binding site [chemical binding]; other site
979982005323	Protein of unknown function (DUF805); Region: DUF805; pfam05656
979982005324	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
979982005325	Transcriptional regulator [Transcription]; Region: LysR; COG0583
979982005326	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
979982005327	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
979982005328	dimerization interface [polypeptide binding]; other site
979982005329	Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075
979982005330	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK06079
979982005331	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
979982005332	NAD binding site [chemical binding]; other site
979982005333	homotetramer interface [polypeptide binding]; other site
979982005334	homodimer interface [polypeptide binding]; other site
979982005335	substrate binding site [chemical binding]; other site
979982005336	active site
979982005337	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
979982005338	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
979982005339	glucan-binding repeat; Region: glucan_65_rpt; TIGR04035
979982005340	allantoate amidohydrolase; Reviewed; Region: PRK09290
979982005341	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
979982005342	active site
979982005343	metal binding site [ion binding]; metal-binding site
979982005344	dimer interface [polypeptide binding]; other site
979982005345	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
979982005346	D-galactonate transporter; Region: 2A0114; TIGR00893
979982005347	putative substrate translocation pore; other site
979982005348	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
979982005349	ThiS interaction site; other site
979982005350	putative active site [active]
979982005351	tetramer interface [polypeptide binding]; other site
979982005352	thiamine biosynthesis protein ThiF; Provisional; Region: PRK08644
979982005353	E1_ThiF_like. Member of superfamily of activating enzymes (E1) of the ubiquitin-like proteins. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like substrate, on...; Region: E1_ThiF_like; cd01487
979982005354	putative ATP binding site [chemical binding]; other site
979982005355	putative substrate interface [chemical binding]; other site
979982005356	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
979982005357	thiS-thiF/thiG interaction site; other site
979982005358	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
979982005359	thiamine phosphate binding site [chemical binding]; other site
979982005360	active site
979982005361	pyrophosphate binding site [ion binding]; other site
979982005362	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255
979982005363	Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514
979982005364	putative metal binding site [ion binding]; other site
979982005365	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
979982005366	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
979982005367	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
979982005368	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
979982005369	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625
979982005370	transmembrane helices; other site
979982005371	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
979982005372	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
979982005373	Coenzyme A binding pocket [chemical binding]; other site
979982005374	T5orf172 domain; Region: T5orf172; pfam10544
979982005375	SnoaL-like domain; Region: SnoaL_2; pfam12680
979982005376	KilA-N domain; Region: KilA-N; pfam04383
979982005377	Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; cl17818
979982005378	ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389
979982005379	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
979982005380	ATP binding site [chemical binding]; other site
979982005381	putative Mg++ binding site [ion binding]; other site
979982005382	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
979982005383	nucleotide binding region [chemical binding]; other site
979982005384	ATP-binding site [chemical binding]; other site
979982005385	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
979982005386	HRDC domain; Region: HRDC; pfam00570
979982005387	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
979982005388	non-specific DNA binding site [nucleotide binding]; other site
979982005389	salt bridge; other site
979982005390	sequence-specific DNA binding site [nucleotide binding]; other site
979982005391	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4200
979982005392	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
979982005393	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
979982005394	ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268
979982005395	Walker A/P-loop; other site
979982005396	ATP binding site [chemical binding]; other site
979982005397	Q-loop/lid; other site
979982005398	ABC transporter signature motif; other site
979982005399	Walker B; other site
979982005400	D-loop; other site
979982005401	H-loop/switch region; other site
979982005402	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
979982005403	ATP binding site [chemical binding]; other site
979982005404	Mg2+ binding site [ion binding]; other site
979982005405	G-X-G motif; other site
979982005406	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
979982005407	Response regulator receiver domain; Region: Response_reg; pfam00072
979982005408	active site
979982005409	phosphorylation site [posttranslational modification]
979982005410	intermolecular recognition site; other site
979982005411	dimerization interface [polypeptide binding]; other site
979982005412	Mrr N-terminal domain; Region: Mrr_N; pfam14338
979982005413	Restriction endonuclease; Region: Mrr_cat; pfam04471
979982005414	Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931
979982005415	Major Facilitator Superfamily; Region: MFS_1; pfam07690
979982005416	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
979982005417	putative substrate translocation pore; other site
979982005418	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
979982005419	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
979982005420	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
979982005421	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267
979982005422	ABC-type transport system involved in cytochrome c biogenesis, ATPase component [Posttranslational modification, protein turnover, chaperones]; Region: CcmA; COG4133
979982005423	Walker A/P-loop; other site
979982005424	ATP binding site [chemical binding]; other site
979982005425	Q-loop/lid; other site
979982005426	ABC transporter signature motif; other site
979982005427	Walker B; other site
979982005428	D-loop; other site
979982005429	H-loop/switch region; other site
979982005430	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
979982005431	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
979982005432	ATP binding site [chemical binding]; other site
979982005433	Mg2+ binding site [ion binding]; other site
979982005434	G-X-G motif; other site
979982005435	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
979982005436	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
979982005437	active site
979982005438	phosphorylation site [posttranslational modification]
979982005439	intermolecular recognition site; other site
979982005440	dimerization interface [polypeptide binding]; other site
979982005441	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
979982005442	DNA binding site [nucleotide binding]
979982005443	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
979982005444	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
979982005445	Walker A/P-loop; other site
979982005446	ATP binding site [chemical binding]; other site
979982005447	Q-loop/lid; other site
979982005448	ABC transporter signature motif; other site
979982005449	Walker B; other site
979982005450	D-loop; other site
979982005451	H-loop/switch region; other site
979982005452	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
979982005453	putative DNA binding site [nucleotide binding]; other site
979982005454	putative Zn2+ binding site [ion binding]; other site
979982005455	Metal binding protein TroA_b.  These proteins are predicted to function as initial receptors in ABC transport of metal ions.  They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: TroA_b; cd01020
979982005456	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
979982005457	metal binding site [ion binding]; metal-binding site
979982005458	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
979982005459	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
979982005460	active site
979982005461	catalytic tetrad [active]
979982005462	ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679
979982005463	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
979982005464	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
979982005465	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
979982005466	Walker A/P-loop; other site
979982005467	ATP binding site [chemical binding]; other site
979982005468	Q-loop/lid; other site
979982005469	ABC transporter signature motif; other site
979982005470	Walker B; other site
979982005471	D-loop; other site
979982005472	H-loop/switch region; other site
979982005473	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
979982005474	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
979982005475	Walker A/P-loop; other site
979982005476	ATP binding site [chemical binding]; other site
979982005477	Q-loop/lid; other site
979982005478	ABC transporter signature motif; other site
979982005479	Walker B; other site
979982005480	D-loop; other site
979982005481	H-loop/switch region; other site
979982005482	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
979982005483	DNA-binding site [nucleotide binding]; DNA binding site
979982005484	Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354
979982005485	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
979982005486	ligand binding site [chemical binding]; other site
979982005487	Protein of unknown function (DUF1440); Region: DUF1440; pfam07274
979982005488	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
979982005489	beta-galactosidase; Region: BGL; TIGR03356
979982005490	PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995
979982005491	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
979982005492	active site turn [active]
979982005493	phosphorylation site [posttranslational modification]
979982005494	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
979982005495	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
979982005496	HPr interaction site; other site
979982005497	glycerol kinase (GK) interaction site [polypeptide binding]; other site
979982005498	active site
979982005499	phosphorylation site [posttranslational modification]
979982005500	transcriptional antiterminator BglG; Provisional; Region: PRK09772
979982005501	CAT RNA binding domain; Region: CAT_RBD; smart01061
979982005502	PRD domain; Region: PRD; pfam00874
979982005503	PRD domain; Region: PRD; pfam00874
979982005504	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
979982005505	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
979982005506	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
979982005507	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
979982005508	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
979982005509	FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454
979982005510	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
979982005511	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
979982005512	active site
979982005513	phosphorylation site [posttranslational modification]
979982005514	intermolecular recognition site; other site
979982005515	dimerization interface [polypeptide binding]; other site
979982005516	LytTr DNA-binding domain; Region: LytTR; cl04498
979982005517	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
979982005518	ATP binding site [chemical binding]; other site
979982005519	Mg2+ binding site [ion binding]; other site
979982005520	G-X-G motif; other site
979982005521	Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352
979982005522	Surface antigen [General function prediction only]; Region: COG3942
979982005523	CHAP domain; Region: CHAP; cl17642
979982005524	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
979982005525	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
979982005526	NAD(P) binding site [chemical binding]; other site
979982005527	active site
979982005528	2-hydroxyacid dehydrogenase; Provisional; Region: PRK08410
979982005529	Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162
979982005530	putative ligand binding site [chemical binding]; other site
979982005531	putative NAD binding site [chemical binding]; other site
979982005532	catalytic site [active]
979982005533	hypothetical protein; Provisional; Region: PRK10281
979982005534	short chain dehydrogenase; Provisional; Region: PRK06914
979982005535	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
979982005536	NADP binding site [chemical binding]; other site
979982005537	active site
979982005538	steroid binding site; other site
979982005539	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
979982005540	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
979982005541	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
979982005542	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
979982005543	active site
979982005544	motif I; other site
979982005545	motif II; other site
979982005546	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
979982005547	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
979982005548	NADH(P)-binding; Region: NAD_binding_10; pfam13460
979982005549	NAD(P) binding site [chemical binding]; other site
979982005550	putative active site [active]
979982005551	coenzyme A disulfide reductase; Reviewed; Region: PRK09564
979982005552	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
979982005553	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
979982005554	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
979982005555	Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028
979982005556	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
979982005557	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
979982005558	DNA binding residues [nucleotide binding]
979982005559	putative dimer interface [polypeptide binding]; other site
979982005560	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
979982005561	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
979982005562	putative substrate translocation pore; other site
979982005563	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
979982005564	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
979982005565	D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186
979982005566	D-lactate dehydrogenase; Validated; Region: PRK08605
979982005567	homodimer interface [polypeptide binding]; other site
979982005568	ligand binding site [chemical binding]; other site
979982005569	NAD binding site [chemical binding]; other site
979982005570	catalytic site [active]
979982005571	tyrosyl-tRNA synthetase; Provisional; Region: PRK13354
979982005572	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
979982005573	active site
979982005574	HIGH motif; other site
979982005575	dimer interface [polypeptide binding]; other site
979982005576	KMSKS motif; other site
979982005577	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
979982005578	RNA binding surface [nucleotide binding]; other site
979982005579	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
979982005580	gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740
979982005581	Walker A/P-loop; other site
979982005582	ATP binding site [chemical binding]; other site
979982005583	Q-loop/lid; other site
979982005584	ABC transporter signature motif; other site
979982005585	Walker B; other site
979982005586	D-loop; other site
979982005587	H-loop/switch region; other site
979982005588	Protein of unknown function (DUF2712); Region: DUF2712; pfam10916
979982005589	Protein of unknown function (DUF975); Region: DUF975; cl10504
979982005590	The Eukaryotic (Putative) Sterol Transporter (EST) Family; Region: 2A060602; TIGR00918
979982005591	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
979982005592	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
979982005593	non-specific DNA binding site [nucleotide binding]; other site
979982005594	salt bridge; other site
979982005595	sequence-specific DNA binding site [nucleotide binding]; other site
979982005596	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
979982005597	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
979982005598	Walker A/P-loop; other site
979982005599	ATP binding site [chemical binding]; other site
979982005600	Q-loop/lid; other site
979982005601	ABC transporter signature motif; other site
979982005602	Walker B; other site
979982005603	D-loop; other site
979982005604	H-loop/switch region; other site
979982005605	Predicted membrane protein [Function unknown]; Region: COG1511
979982005606	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
979982005607	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
979982005608	probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366
979982005609	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
979982005610	Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278
979982005611	Domain of unknown function DUF87; Region: DUF87; pfam01935
979982005612	AAA-like domain; Region: AAA_10; pfam12846
979982005613	Enterocin A Immunity; Region: EntA_Immun; pfam08951
979982005614	cytochrome aa3 quinol oxidase, subunit I; Region: QoxB; TIGR02882
979982005615	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
979982005616	non-specific DNA binding site [nucleotide binding]; other site
979982005617	salt bridge; other site
979982005618	sequence-specific DNA binding site [nucleotide binding]; other site
979982005619	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
979982005620	Coenzyme A binding pocket [chemical binding]; other site
979982005621	CAAX protease self-immunity; Region: Abi; pfam02517
979982005622	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
979982005623	non-specific DNA binding site [nucleotide binding]; other site
979982005624	salt bridge; other site
979982005625	sequence-specific DNA binding site [nucleotide binding]; other site
979982005626	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
979982005627	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
979982005628	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
979982005629	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
979982005630	non-specific DNA binding site [nucleotide binding]; other site
979982005631	salt bridge; other site
979982005632	sequence-specific DNA binding site [nucleotide binding]; other site
979982005633	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296
979982005634	putative active site [active]
979982005635	Integral membrane protein DUF95; Region: DUF95; pfam01944
979982005636	CAAX protease self-immunity; Region: Abi; pfam02517
979982005637	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
979982005638	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
979982005639	non-specific DNA binding site [nucleotide binding]; other site
979982005640	salt bridge; other site
979982005641	sequence-specific DNA binding site [nucleotide binding]; other site
979982005642	CAAX protease self-immunity; Region: Abi; pfam02517
979982005643	Bacteriocin class II with double-glycine leader peptide; Region: Bacteriocin_IIc; pfam10439
979982005644	CAAX protease self-immunity; Region: Abi; pfam02517
979982005645	CAAX protease self-immunity; Region: Abi; pfam02517
979982005646	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
979982005647	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
979982005648	non-specific DNA binding site [nucleotide binding]; other site
979982005649	salt bridge; other site
979982005650	sequence-specific DNA binding site [nucleotide binding]; other site
979982005651	Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278
979982005652	Predicted permeases [General function prediction only]; Region: RarD; COG2962
979982005653	serine O-acetyltransferase; Region: cysE; TIGR01172
979982005654	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
979982005655	trimer interface [polypeptide binding]; other site
979982005656	active site
979982005657	substrate binding site [chemical binding]; other site
979982005658	CoA binding site [chemical binding]; other site
979982005659	cystathionine beta-lyase; Provisional; Region: PRK07671
979982005660	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
979982005661	homodimer interface [polypeptide binding]; other site
979982005662	substrate-cofactor binding pocket; other site
979982005663	pyridoxal 5'-phosphate binding site [chemical binding]; other site
979982005664	catalytic residue [active]
979982005665	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
979982005666	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
979982005667	dimer interface [polypeptide binding]; other site
979982005668	pyridoxal 5'-phosphate binding site [chemical binding]; other site
979982005669	catalytic residue [active]
979982005670	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
979982005671	Spore germination protein; Region: Spore_permease; cl17796
979982005672	Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878
979982005673	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
979982005674	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
979982005675	Walker A/P-loop; other site
979982005676	ATP binding site [chemical binding]; other site
979982005677	Q-loop/lid; other site
979982005678	ABC transporter signature motif; other site
979982005679	Walker B; other site
979982005680	D-loop; other site
979982005681	H-loop/switch region; other site
979982005682	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
979982005683	dimer interface [polypeptide binding]; other site
979982005684	conserved gate region; other site
979982005685	putative PBP binding loops; other site
979982005686	ABC-ATPase subunit interface; other site
979982005687	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
979982005688	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
979982005689	substrate binding pocket [chemical binding]; other site
979982005690	membrane-bound complex binding site; other site
979982005691	hinge residues; other site
979982005692	Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626
979982005693	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
979982005694	homodimer interface [polypeptide binding]; other site
979982005695	substrate-cofactor binding pocket; other site
979982005696	pyridoxal 5'-phosphate binding site [chemical binding]; other site
979982005697	catalytic residue [active]
979982005698	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
979982005699	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
979982005700	metal binding site [ion binding]; metal-binding site
979982005701	Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468
979982005702	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
979982005703	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
979982005704	tetramer (dimer of dimers) interface [polypeptide binding]; other site
979982005705	active site
979982005706	dimer interface [polypeptide binding]; other site
979982005707	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
979982005708	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
979982005709	substrate binding site [chemical binding]; other site
979982005710	dimer interface [polypeptide binding]; other site
979982005711	ATP binding site [chemical binding]; other site
979982005712	Transcriptional regulators [Transcription]; Region: PurR; COG1609
979982005713	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
979982005714	DNA binding site [nucleotide binding]
979982005715	domain linker motif; other site
979982005716	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
979982005717	dimerization interface [polypeptide binding]; other site
979982005718	ligand binding site [chemical binding]; other site
979982005719	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
979982005720	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
979982005721	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
979982005722	nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651
979982005723	active site
979982005724	tetramer interface [polypeptide binding]; other site
979982005725	NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650
979982005726	active site
979982005727	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
979982005728	dimerization interface [polypeptide binding]; other site
979982005729	putative DNA binding site [nucleotide binding]; other site
979982005730	putative Zn2+ binding site [ion binding]; other site
979982005731	Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196
979982005732	substrate interface [chemical binding]; other site
979982005733	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
979982005734	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
979982005735	Walker A/P-loop; other site
979982005736	ATP binding site [chemical binding]; other site
979982005737	Q-loop/lid; other site
979982005738	ABC transporter signature motif; other site
979982005739	Walker B; other site
979982005740	D-loop; other site
979982005741	H-loop/switch region; other site
979982005742	ABC-2 type transporter; Region: ABC2_membrane; cl17235
979982005743	H+ Antiporter protein; Region: 2A0121; TIGR00900
979982005744	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
979982005745	non-specific DNA binding site [nucleotide binding]; other site
979982005746	salt bridge; other site
979982005747	sequence-specific DNA binding site [nucleotide binding]; other site
979982005748	transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716
979982005749	H+ Antiporter protein; Region: 2A0121; TIGR00900
979982005750	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
979982005751	putative substrate translocation pore; other site
979982005752	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
979982005753	non-specific DNA binding site [nucleotide binding]; other site
979982005754	salt bridge; other site
979982005755	sequence-specific DNA binding site [nucleotide binding]; other site
979982005756	transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716
979982005757	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
979982005758	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
979982005759	active site
979982005760	catalytic residues [active]
979982005761	L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193
979982005762	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214
979982005763	intersubunit interface [polypeptide binding]; other site
979982005764	active site
979982005765	Zn2+ binding site [ion binding]; other site
979982005766	L-ribulokinase-like proteins; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-RBK_like; cd07778
979982005767	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
979982005768	putative N- and C-terminal domain interface [polypeptide binding]; other site
979982005769	putative active site [active]
979982005770	MgATP binding site [chemical binding]; other site
979982005771	catalytic site [active]
979982005772	metal binding site [ion binding]; metal-binding site
979982005773	putative carbohydrate binding site [chemical binding]; other site
979982005774	galactoside permease; Reviewed; Region: lacY; PRK09528
979982005775	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
979982005776	putative substrate translocation pore; other site
979982005777	Glycosyl hydrolase family 43; Region: GH43_1; cd08980
979982005778	active site
979982005779	L-arabinose isomerase; Provisional; Region: PRK02929
979982005780	L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947
979982005781	hexamer (dimer of trimers) interface [polypeptide binding]; other site
979982005782	trimer interface [polypeptide binding]; other site
979982005783	substrate binding site [chemical binding]; other site
979982005784	Mn binding site [ion binding]; other site
979982005785	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
979982005786	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
979982005787	intersubunit interface [polypeptide binding]; other site
979982005788	active site
979982005789	zinc binding site [ion binding]; other site
979982005790	Na+ binding site [ion binding]; other site
979982005791	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
979982005792	DNA-binding site [nucleotide binding]; DNA binding site
979982005793	Transcriptional regulators [Transcription]; Region: PurR; COG1609
979982005794	Ligand-binding domain of DNA transcription repressor specific for arabinose (AraR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AraR; cd01541
979982005795	putative dimerization interface [polypeptide binding]; other site
979982005796	putative ligand binding site [chemical binding]; other site
979982005797	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
979982005798	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
979982005799	non-specific DNA binding site [nucleotide binding]; other site
979982005800	salt bridge; other site
979982005801	sequence-specific DNA binding site [nucleotide binding]; other site
979982005802	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
979982005803	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
979982005804	Coenzyme A binding pocket [chemical binding]; other site
979982005805	Transcriptional regulator [Transcription]; Region: LysR; COG0583
979982005806	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
979982005807	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
979982005808	dimerization interface [polypeptide binding]; other site
979982005809	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
979982005810	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
979982005811	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
979982005812	non-specific DNA binding site [nucleotide binding]; other site
979982005813	salt bridge; other site
979982005814	sequence-specific DNA binding site [nucleotide binding]; other site
979982005815	BacA is a bacterial lysin from Enterococcus faecalis that degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. BacA is homologous to the YbfG and YkuG lysins of...; Region: GH25_BacA-like; cd06418
979982005816	active site
979982005817	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
979982005818	FtsX-like permease family; Region: FtsX; pfam02687
979982005819	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
979982005820	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
979982005821	Walker A/P-loop; other site
979982005822	ATP binding site [chemical binding]; other site
979982005823	Q-loop/lid; other site
979982005824	ABC transporter signature motif; other site
979982005825	Walker B; other site
979982005826	D-loop; other site
979982005827	H-loop/switch region; other site
979982005828	Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845
979982005829	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
979982005830	HlyD family secretion protein; Region: HlyD_3; pfam13437
979982005831	Transcriptional regulator [Transcription]; Region: LysR; COG0583
979982005832	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
979982005833	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
979982005834	dimerization interface [polypeptide binding]; other site
979982005835	Predicted transcriptional regulators [Transcription]; Region: COG1695
979982005836	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
979982005837	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
979982005838	PspC domain; Region: PspC; pfam04024
979982005839	DNA gyrase subunit A; Validated; Region: PRK05560
979982005840	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
979982005841	CAP-like domain; other site
979982005842	active site
979982005843	primary dimer interface [polypeptide binding]; other site
979982005844	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
979982005845	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
979982005846	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
979982005847	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
979982005848	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
979982005849	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
979982005850	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
979982005851	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
979982005852	Mg2+ binding site [ion binding]; other site
979982005853	G-X-G motif; other site
979982005854	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
979982005855	anchoring element; other site
979982005856	dimer interface [polypeptide binding]; other site
979982005857	ATP binding site [chemical binding]; other site
979982005858	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
979982005859	active site
979982005860	putative metal-binding site [ion binding]; other site
979982005861	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
979982005862	recombination protein F; Reviewed; Region: recF; PRK00064
979982005863	ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242
979982005864	Walker A/P-loop; other site
979982005865	ATP binding site [chemical binding]; other site
979982005866	Q-loop/lid; other site
979982005867	S4 domain; Region: S4_2; pfam13275
979982005868	DNA polymerase III subunit beta; Validated; Region: PRK05643
979982005869	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
979982005870	putative DNA binding surface [nucleotide binding]; other site
979982005871	dimer interface [polypeptide binding]; other site
979982005872	beta-clamp/clamp loader binding surface; other site
979982005873	beta-clamp/translesion DNA polymerase binding surface; other site
979982005874	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
979982005875	DnaA N-terminal domain; Region: DnaA_N; pfam11638
979982005876	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
979982005877	Walker A motif; other site
979982005878	ATP binding site [chemical binding]; other site
979982005879	Walker B motif; other site
979982005880	arginine finger; other site
979982005881	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
979982005882	DnaA box-binding interface [nucleotide binding]; other site
979982005883	Pseudouridine synthase, Escherichia coli RluE; Region: PseudoU_synth_RluE; cd02566
979982005884	pseudouridine synthase; Region: TIGR00093
979982005885	probable active site [active]
979982005886	hypothetical protein; Provisional; Region: PRK12378
979982005887	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399
979982005888	ribonuclease P; Reviewed; Region: rnpA; PRK00499
979982005889	Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706
979982005890	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
979982005891	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
979982005892	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
979982005893	active site
979982005894	catalytic site [active]
979982005895	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
979982005896	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
979982005897	Catalytic site [active]
979982005898	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
979982005899	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
979982005900	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
979982005901	Coenzyme A binding pocket [chemical binding]; other site
979982005902	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
979982005903	uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827
979982005904	Cl binding site [ion binding]; other site
979982005905	oligomer interface [polypeptide binding]; other site
979982005906	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
979982005907	active site
979982005908	accessory Sec system protein Asp1; Region: acc_sec_asp1; TIGR03713
979982005909	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
979982005910	accessory Sec system protein Asp2; Region: acc_sec_asp2; TIGR03712
979982005911	accessory Sec system protein Asp3; Region: acc_sec_asp3; TIGR03711
979982005912	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
979982005913	CoenzymeA binding site [chemical binding]; other site
979982005914	subunit interaction site [polypeptide binding]; other site
979982005915	PHB binding site; other site
979982005916	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
979982005917	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
979982005918	substrate binding site [chemical binding]; other site
979982005919	oxyanion hole (OAH) forming residues; other site
979982005920	trimer interface [polypeptide binding]; other site
979982005921	Predicted amidohydrolase [General function prediction only]; Region: COG0388
979982005922	Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583
979982005923	putative active site [active]
979982005924	catalytic triad [active]
979982005925	putative dimer interface [polypeptide binding]; other site
979982005926	transaminase; Reviewed; Region: PRK08068
979982005927	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
979982005928	pyridoxal 5'-phosphate binding site [chemical binding]; other site
979982005929	homodimer interface [polypeptide binding]; other site
979982005930	catalytic residue [active]
979982005931	potential protein location (hypothetical protein LGMK_09355 [Leuconostoc sp. C2]) that overlaps RNA (tRNA-A)