-- dump date 20140619_131445 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1162668000001 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 1162668000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1162668000003 Walker A motif; other site 1162668000004 ATP binding site [chemical binding]; other site 1162668000005 Walker B motif; other site 1162668000006 arginine finger; other site 1162668000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1162668000008 DnaA box-binding interface [nucleotide binding]; other site 1162668000009 DNA polymerase III subunit beta; Validated; Region: PRK05643 1162668000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1162668000011 putative DNA binding surface [nucleotide binding]; other site 1162668000012 dimer interface [polypeptide binding]; other site 1162668000013 beta-clamp/clamp loader binding surface; other site 1162668000014 beta-clamp/translesion DNA polymerase binding surface; other site 1162668000015 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 1162668000016 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1162668000017 Mg2+ binding site [ion binding]; other site 1162668000018 G-X-G motif; other site 1162668000019 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1162668000020 anchoring element; other site 1162668000021 dimer interface [polypeptide binding]; other site 1162668000022 ATP binding site [chemical binding]; other site 1162668000023 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1162668000024 active site 1162668000025 putative metal-binding site [ion binding]; other site 1162668000026 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1162668000027 DNA gyrase subunit A; Validated; Region: PRK05560 1162668000028 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1162668000029 CAP-like domain; other site 1162668000030 active site 1162668000031 primary dimer interface [polypeptide binding]; other site 1162668000032 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1162668000033 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1162668000034 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1162668000035 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1162668000036 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1162668000037 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1162668000038 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 1162668000039 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE, gammaproteobacterial type; Region: rSAM_QueE_gams; TIGR04349 1162668000040 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1162668000041 FeS/SAM binding site; other site 1162668000042 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 1162668000043 Ligand Binding Site [chemical binding]; other site 1162668000044 multifunctional aminopeptidase A; Provisional; Region: PRK00913 1162668000045 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1162668000046 interface (dimer of trimers) [polypeptide binding]; other site 1162668000047 Substrate-binding/catalytic site; other site 1162668000048 Zn-binding sites [ion binding]; other site 1162668000049 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1162668000050 SmpB-tmRNA interface; other site 1162668000051 potential frameshift: common BLAST hit: gi|53802914|ref|YP_115393.1| DEAD/DEAH box helicase 1162668000052 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1162668000053 ATP binding site [chemical binding]; other site 1162668000054 putative Mg++ binding site [ion binding]; other site 1162668000055 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 1162668000056 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1162668000057 nucleotide binding region [chemical binding]; other site 1162668000058 ATP-binding site [chemical binding]; other site 1162668000059 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1162668000060 Domain of unknown function (DUF3883); Region: DUF3883; pfam13020 1162668000061 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 1162668000062 Protein of unknown function (DUF1156); Region: DUF1156; pfam06634 1162668000063 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 1162668000064 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 1162668000065 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 1162668000066 Protein of unknown function (DUF2283); Region: DUF2283; pfam10049 1162668000067 Protein of unknown function, DUF481; Region: DUF481; cl01213 1162668000068 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1162668000069 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1162668000070 metal binding site [ion binding]; metal-binding site 1162668000071 active site 1162668000072 I-site; other site 1162668000073 Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434 1162668000074 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1162668000075 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1162668000076 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1162668000077 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1162668000078 dimer interface [polypeptide binding]; other site 1162668000079 putative CheW interface [polypeptide binding]; other site 1162668000080 PAS domain; Region: PAS; smart00091 1162668000081 PAS fold; Region: PAS_4; pfam08448 1162668000082 PAS domain S-box; Region: sensory_box; TIGR00229 1162668000083 PAS domain; Region: PAS_8; pfam13188 1162668000084 PAS domain; Region: PAS_9; pfam13426 1162668000085 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1162668000086 putative active site [active] 1162668000087 heme pocket [chemical binding]; other site 1162668000088 PAS domain S-box; Region: sensory_box; TIGR00229 1162668000089 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1162668000090 putative active site [active] 1162668000091 heme pocket [chemical binding]; other site 1162668000092 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1162668000093 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1162668000094 metal binding site [ion binding]; metal-binding site 1162668000095 active site 1162668000096 I-site; other site 1162668000097 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1162668000098 PAS domain; Region: PAS_9; pfam13426 1162668000099 putative active site [active] 1162668000100 heme pocket [chemical binding]; other site 1162668000101 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1162668000102 GAF domain; Region: GAF; pfam01590 1162668000103 PAS domain S-box; Region: sensory_box; TIGR00229 1162668000104 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1162668000105 GAF domain; Region: GAF; pfam01590 1162668000106 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1162668000107 PAS domain; Region: PAS_9; pfam13426 1162668000108 putative active site [active] 1162668000109 heme pocket [chemical binding]; other site 1162668000110 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1162668000111 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1162668000112 metal binding site [ion binding]; metal-binding site 1162668000113 active site 1162668000114 I-site; other site 1162668000115 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 1162668000116 heme-binding site [chemical binding]; other site 1162668000117 Domain of unknown function (DUF4412); Region: DUF4412; pfam14371 1162668000118 Queuosine biosynthesis protein; Region: Queuosine_synth; pfam02547 1162668000119 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 1162668000120 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 1162668000121 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1162668000122 dimerization interface [polypeptide binding]; other site 1162668000123 PAS domain; Region: PAS; smart00091 1162668000124 putative active site [active] 1162668000125 heme pocket [chemical binding]; other site 1162668000126 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1162668000127 dimer interface [polypeptide binding]; other site 1162668000128 phosphorylation site [posttranslational modification] 1162668000129 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1162668000130 ATP binding site [chemical binding]; other site 1162668000131 Mg2+ binding site [ion binding]; other site 1162668000132 G-X-G motif; other site 1162668000133 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1162668000134 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1162668000135 active site 1162668000136 phosphorylation site [posttranslational modification] 1162668000137 intermolecular recognition site; other site 1162668000138 dimerization interface [polypeptide binding]; other site 1162668000139 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1162668000140 Walker A motif; other site 1162668000141 ATP binding site [chemical binding]; other site 1162668000142 Walker B motif; other site 1162668000143 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1162668000144 3-oxoacyl-(acyl-carrier-protein) synthase III; Region: fabH; TIGR00747 1162668000145 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1162668000146 dimer interface [polypeptide binding]; other site 1162668000147 active site 1162668000148 CoA binding pocket [chemical binding]; other site 1162668000149 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 1162668000150 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1162668000151 TPR motif; other site 1162668000152 binding surface 1162668000153 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1162668000154 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 1162668000155 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 1162668000156 putative glutamate synthase (NADPH) small subunit; Provisional; Region: PRK12771 1162668000157 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1162668000158 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1162668000159 4Fe-4S binding domain; Region: Fer4; pfam00037 1162668000160 pyruvate ferredoxin oxidoreductase subunit beta; Provisional; Region: PRK11865 1162668000161 Thiamine pyrophosphate (TPP family), PFOR porB-like subfamily, TPP-binding module; composed of proteins similar to the beta subunit (porB) of the Helicobacter pylori four-subunit pyruvate ferredoxin oxidoreductase (PFOR), which are also found in archaea...; Region: TPP_PFOR_porB_like; cd03376 1162668000162 TPP-binding site [chemical binding]; other site 1162668000163 putative dimer interface [polypeptide binding]; other site 1162668000164 pyruvate ferredoxin oxidoreductase subunit alpha; Reviewed; Region: porA; PRK08367 1162668000165 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 1162668000166 dimer interface [polypeptide binding]; other site 1162668000167 PYR/PP interface [polypeptide binding]; other site 1162668000168 TPP binding site [chemical binding]; other site 1162668000169 substrate binding site [chemical binding]; other site 1162668000170 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 1162668000171 pyruvate/ketoisovalerate ferredoxin oxidoreductase subunit gamma; Provisional; Region: PRK14029 1162668000172 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 1162668000173 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1162668000174 triosephosphate isomerase; Provisional; Region: PRK14565 1162668000175 substrate binding site [chemical binding]; other site 1162668000176 dimer interface [polypeptide binding]; other site 1162668000177 catalytic triad [active] 1162668000178 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1162668000179 active site 1162668000180 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 1162668000181 Transglycosylase; Region: Transgly; pfam00912 1162668000182 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1162668000183 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1162668000184 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729 1162668000185 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1162668000186 Phosphoglycerate kinase; Region: PGK; pfam00162 1162668000187 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 1162668000188 substrate binding site [chemical binding]; other site 1162668000189 hinge regions; other site 1162668000190 ADP binding site [chemical binding]; other site 1162668000191 catalytic site [active] 1162668000192 Preprotein translocase SecG subunit; Region: SecG; pfam03840 1162668000193 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1162668000194 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_4; cd08500 1162668000195 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1162668000196 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1162668000197 dimer interface [polypeptide binding]; other site 1162668000198 conserved gate region; other site 1162668000199 putative PBP binding loops; other site 1162668000200 ABC-ATPase subunit interface; other site 1162668000201 microcin C ABC transporter permease; Provisional; Region: PRK15021 1162668000202 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1162668000203 dimer interface [polypeptide binding]; other site 1162668000204 conserved gate region; other site 1162668000205 putative PBP binding loops; other site 1162668000206 ABC-ATPase subunit interface; other site 1162668000207 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1162668000208 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1162668000209 active site 1162668000210 motif I; other site 1162668000211 motif II; other site 1162668000212 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1162668000213 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527 1162668000214 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 1162668000215 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 1162668000216 F0F1 ATP synthase subunit C; Provisional; Region: PRK13469 1162668000217 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 1162668000218 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 1162668000219 F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; cl17210 1162668000220 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 1162668000221 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1162668000222 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1162668000223 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1162668000224 beta subunit interaction interface [polypeptide binding]; other site 1162668000225 Walker A motif; other site 1162668000226 ATP binding site [chemical binding]; other site 1162668000227 Walker B motif; other site 1162668000228 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1162668000229 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1162668000230 core domain interface [polypeptide binding]; other site 1162668000231 delta subunit interface [polypeptide binding]; other site 1162668000232 epsilon subunit interface [polypeptide binding]; other site 1162668000233 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1162668000234 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1162668000235 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1162668000236 alpha subunit interaction interface [polypeptide binding]; other site 1162668000237 Walker A motif; other site 1162668000238 ATP binding site [chemical binding]; other site 1162668000239 Walker B motif; other site 1162668000240 inhibitor binding site; inhibition site 1162668000241 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1162668000242 F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK13446 1162668000243 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1162668000244 gamma subunit interface [polypeptide binding]; other site 1162668000245 epsilon subunit interface [polypeptide binding]; other site 1162668000246 LBP interface [polypeptide binding]; other site 1162668000247 Helix-turn-helix domain; Region: HTH_31; pfam13560 1162668000248 non-specific DNA binding site [nucleotide binding]; other site 1162668000249 salt bridge; other site 1162668000250 sequence-specific DNA binding site [nucleotide binding]; other site 1162668000251 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1162668000252 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1162668000253 MULE transposase domain; Region: MULE; pfam10551 1162668000254 putative transposase OrfB; Reviewed; Region: PHA02517 1162668000255 Homeodomain-like domain; Region: HTH_32; pfam13565 1162668000256 Integrase core domain; Region: rve; pfam00665 1162668000257 Integrase core domain; Region: rve_3; pfam13683 1162668000258 Transposase; Region: HTH_Tnp_1; cl17663 1162668000259 Domain of unknown function DUF302; Region: DUF302; pfam03625 1162668000260 Putative zinc-finger; Region: zf-HC2; pfam13490 1162668000261 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1162668000262 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1162668000263 RNA polymerase sigma-70 factor, TIGR02943 family; Region: Sig70_famx1 1162668000264 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1162668000265 DNA binding residues [nucleotide binding] 1162668000266 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1162668000267 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1162668000268 active site 1162668000269 phosphorylation site [posttranslational modification] 1162668000270 intermolecular recognition site; other site 1162668000271 dimerization interface [polypeptide binding]; other site 1162668000272 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1162668000273 DNA binding site [nucleotide binding] 1162668000274 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1162668000275 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1162668000276 dimerization interface [polypeptide binding]; other site 1162668000277 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1162668000278 dimer interface [polypeptide binding]; other site 1162668000279 phosphorylation site [posttranslational modification] 1162668000280 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1162668000281 ATP binding site [chemical binding]; other site 1162668000282 Mg2+ binding site [ion binding]; other site 1162668000283 G-X-G motif; other site 1162668000284 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1162668000285 dimerization interface [polypeptide binding]; other site 1162668000286 putative DNA binding site [nucleotide binding]; other site 1162668000287 putative Zn2+ binding site [ion binding]; other site 1162668000288 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1162668000289 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1162668000290 active site 1162668000291 Arsenical resistance operon trans-acting repressor ArsD; Region: ArsD; pfam06953 1162668000292 arsenical pump-driving ATPase; Region: arsen_driv_ArsA; TIGR04291 1162668000293 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1162668000294 DTAP/Switch II; other site 1162668000295 Switch I; other site 1162668000296 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1162668000297 DTAP/Switch II; other site 1162668000298 Switch I; other site 1162668000299 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276 1162668000300 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1162668000301 putative NAD(P) binding site [chemical binding]; other site 1162668000302 DNA recombination protein RmuC; Provisional; Region: PRK10361 1162668000303 RmuC family; Region: RmuC; pfam02646 1162668000304 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1162668000305 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1162668000306 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 1162668000307 putative metal binding site [ion binding]; other site 1162668000308 putative homodimer interface [polypeptide binding]; other site 1162668000309 putative homotetramer interface [polypeptide binding]; other site 1162668000310 putative homodimer-homodimer interface [polypeptide binding]; other site 1162668000311 putative allosteric switch controlling residues; other site 1162668000312 Winged helix-turn helix; Region: HTH_29; pfam13551 1162668000313 Homeodomain-like domain; Region: HTH_23; pfam13384 1162668000314 Integrase core domain; Region: rve; pfam00665 1162668000315 TPR repeat; Region: TPR_11; pfam13414 1162668000316 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1162668000317 binding surface 1162668000318 TPR motif; other site 1162668000319 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1162668000320 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1162668000321 active site 1162668000322 metal binding site [ion binding]; metal-binding site 1162668000323 acetyl-CoA synthetase; Provisional; Region: PRK00174 1162668000324 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 1162668000325 active site 1162668000326 CoA binding site [chemical binding]; other site 1162668000327 acyl-activating enzyme (AAE) consensus motif; other site 1162668000328 AMP binding site [chemical binding]; other site 1162668000329 acetate binding site [chemical binding]; other site 1162668000330 PEP-CTERM motif; Region: VPEP; pfam07589 1162668000331 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 1162668000332 ThiS interaction site; other site 1162668000333 putative active site [active] 1162668000334 tetramer interface [polypeptide binding]; other site 1162668000335 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1162668000336 thiamine phosphate binding site [chemical binding]; other site 1162668000337 active site 1162668000338 pyrophosphate binding site [ion binding]; other site 1162668000339 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1162668000340 Peptidase family M23; Region: Peptidase_M23; pfam01551 1162668000341 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1162668000342 dimer interface [polypeptide binding]; other site 1162668000343 substrate binding site [chemical binding]; other site 1162668000344 ATP binding site [chemical binding]; other site 1162668000345 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b1; cd09203 1162668000346 PLD-like domain; Region: PLDc_2; pfam13091 1162668000347 putative homodimer interface [polypeptide binding]; other site 1162668000348 putative active site [active] 1162668000349 catalytic site [active] 1162668000350 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1162668000351 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 1162668000352 putative Mg++ binding site [ion binding]; other site 1162668000353 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1162668000354 nucleotide binding region [chemical binding]; other site 1162668000355 ATP-binding site [chemical binding]; other site 1162668000356 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 1162668000357 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033 1162668000358 putative uracil binding site [chemical binding]; other site 1162668000359 putative active site [active] 1162668000360 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 1162668000361 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1162668000362 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1162668000363 active site 1162668000364 dimer interface [polypeptide binding]; other site 1162668000365 motif 1; other site 1162668000366 motif 2; other site 1162668000367 motif 3; other site 1162668000368 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1162668000369 anticodon binding site; other site 1162668000370 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 1162668000371 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1162668000372 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1162668000373 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1162668000374 23S rRNA binding site [nucleotide binding]; other site 1162668000375 L21 binding site [polypeptide binding]; other site 1162668000376 L13 binding site [polypeptide binding]; other site 1162668000377 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK09616 1162668000378 tRNA synthetase B5 domain; Region: B5; pfam03484 1162668000379 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1162668000380 motif 1; other site 1162668000381 dimer interface [polypeptide binding]; other site 1162668000382 active site 1162668000383 motif 2; other site 1162668000384 motif 3; other site 1162668000385 phenylalanyl-tRNA synthetase subunit alpha; Provisional; Region: pheS; PRK04172 1162668000386 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1162668000387 dimer interface [polypeptide binding]; other site 1162668000388 motif 1; other site 1162668000389 active site 1162668000390 motif 2; other site 1162668000391 motif 3; other site 1162668000392 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1162668000393 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1162668000394 Walker A/P-loop; other site 1162668000395 ATP binding site [chemical binding]; other site 1162668000396 Q-loop/lid; other site 1162668000397 ABC transporter signature motif; other site 1162668000398 Walker B; other site 1162668000399 D-loop; other site 1162668000400 H-loop/switch region; other site 1162668000401 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1162668000402 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1162668000403 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1162668000404 Walker A/P-loop; other site 1162668000405 ATP binding site [chemical binding]; other site 1162668000406 Q-loop/lid; other site 1162668000407 ABC transporter signature motif; other site 1162668000408 Walker B; other site 1162668000409 D-loop; other site 1162668000410 H-loop/switch region; other site 1162668000411 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1162668000412 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 1162668000413 active site 1162668000414 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 1162668000415 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1162668000416 metal binding site 2 [ion binding]; metal-binding site 1162668000417 putative DNA binding helix; other site 1162668000418 metal binding site 1 [ion binding]; metal-binding site 1162668000419 dimer interface [polypeptide binding]; other site 1162668000420 structural Zn2+ binding site [ion binding]; other site 1162668000421 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1162668000422 DNA binding site [nucleotide binding] 1162668000423 Int/Topo IB signature motif; other site 1162668000424 active site 1162668000425 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 1162668000426 Divergent AAA domain; Region: AAA_4; pfam04326 1162668000427 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 1162668000428 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1162668000429 Helix-turn-helix domain; Region: HTH_17; pfam12728 1162668000430 Integrase core domain; Region: rve; pfam00665 1162668000431 Integrase core domain; Region: rve_3; pfam13683 1162668000432 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1162668000433 Protein of unknown function (Hypoth_ymh); Region: Hypoth_Ymh; cl09741 1162668000434 probable addiction module antidote protein; Region: dnstrm_HI1420; TIGR02684 1162668000435 putative addiction module killer protein; Region: upstrm_HI1419; TIGR02683 1162668000436 Protein of unknown function (DUF2283); Region: DUF2283; pfam10049 1162668000437 putative addiction module killer protein; Region: upstrm_HI1419; TIGR02683 1162668000438 probable addiction module antidote protein; Region: dnstrm_HI1420; TIGR02684 1162668000439 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 1162668000440 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1162668000441 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1162668000442 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1162668000443 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1162668000444 active site 1162668000445 catalytic tetrad [active] 1162668000446 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1162668000447 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 1162668000448 putative NAD(P) binding site [chemical binding]; other site 1162668000449 putative substrate binding site [chemical binding]; other site 1162668000450 catalytic Zn binding site [ion binding]; other site 1162668000451 structural Zn binding site [ion binding]; other site 1162668000452 dimer interface [polypeptide binding]; other site 1162668000453 CHASE3 domain; Region: CHASE3; pfam05227 1162668000454 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1162668000455 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1162668000456 metal binding site [ion binding]; metal-binding site 1162668000457 active site 1162668000458 I-site; other site 1162668000459 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1162668000460 metabolite-proton symporter; Region: 2A0106; TIGR00883 1162668000461 putative substrate translocation pore; other site 1162668000462 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1162668000463 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1162668000464 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1162668000465 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1162668000466 Sel1-like repeats; Region: SEL1; smart00671 1162668000467 Sel1-like repeats; Region: SEL1; smart00671 1162668000468 Sel1-like repeats; Region: SEL1; smart00671 1162668000469 Sel1-like repeats; Region: SEL1; smart00671 1162668000470 Caspase domain; Region: Peptidase_C14; pfam00656 1162668000471 HNH endonuclease; Region: HNH_4; pfam13395 1162668000472 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 1162668000473 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1162668000474 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1162668000475 ABC transporter; Region: ABC_tran_2; pfam12848 1162668000476 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1162668000477 putative mercuric reductase; Provisional; Region: PRK13748 1162668000478 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1162668000479 metal-binding site [ion binding] 1162668000480 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1162668000481 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1162668000482 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1162668000483 Helix-Turn-Helix DNA binding domain of the MerR1 transcription regulator; Region: HTH_MerR1; cd04783 1162668000484 DNA binding residues [nucleotide binding] 1162668000485 Hg(II)-responsive transcriptional regulator; Region: MerR; TIGR02051 1162668000486 dimer interface [polypeptide binding]; other site 1162668000487 mercury binding site [ion binding]; other site 1162668000488 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1162668000489 TPR motif; other site 1162668000490 binding surface 1162668000491 Protein of unknown function (DUF2810); Region: DUF2810; cl08159 1162668000492 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1162668000493 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1162668000494 active site 1162668000495 metal binding site [ion binding]; metal-binding site 1162668000496 DNA binding site [nucleotide binding] 1162668000497 P-loop containing region of AAA domain; Region: AAA_29; pfam13555 1162668000498 AAA domain; Region: AAA_27; pfam13514 1162668000499 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1162668000500 Q-loop/lid; other site 1162668000501 ABC transporter signature motif; other site 1162668000502 Walker B; other site 1162668000503 D-loop; other site 1162668000504 H-loop/switch region; other site 1162668000505 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 1162668000506 DNA photolyase; Region: DNA_photolyase; pfam00875 1162668000507 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1162668000508 C-3',4' desaturase CrtD; Region: desat_CrtD; TIGR02733 1162668000509 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1162668000510 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1162668000511 S-adenosylmethionine binding site [chemical binding]; other site 1162668000512 AmmeMemoRadiSam system radical SAM enzyme; Region: AmmeMemoSam_rS; TIGR04337 1162668000513 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1162668000514 FeS/SAM binding site; other site 1162668000515 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 1162668000516 AmmeMemoRadiSam system protein A; Region: AmmeMemoSam_A; TIGR04335 1162668000517 AMMECR1; Region: AMMECR1; pfam01871 1162668000518 Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility; Region: MEMO_like; cd07361 1162668000519 putative ligand binding pocket/active site [active] 1162668000520 putative metal binding site [ion binding]; other site 1162668000521 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 1162668000522 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 1162668000523 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1162668000524 active site 1162668000525 dimer interface [polypeptide binding]; other site 1162668000526 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1162668000527 dimer interface [polypeptide binding]; other site 1162668000528 active site 1162668000529 Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382 1162668000530 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1162668000531 GTPase CgtA; Reviewed; Region: obgE; PRK12299 1162668000532 GTP1/OBG; Region: GTP1_OBG; pfam01018 1162668000533 Obg GTPase; Region: Obg; cd01898 1162668000534 G1 box; other site 1162668000535 GTP/Mg2+ binding site [chemical binding]; other site 1162668000536 Switch I region; other site 1162668000537 G2 box; other site 1162668000538 G3 box; other site 1162668000539 Switch II region; other site 1162668000540 G4 box; other site 1162668000541 G5 box; other site 1162668000542 gamma-glutamyl kinase; Provisional; Region: PRK05429 1162668000543 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1162668000544 nucleotide binding site [chemical binding]; other site 1162668000545 homotetrameric interface [polypeptide binding]; other site 1162668000546 putative phosphate binding site [ion binding]; other site 1162668000547 putative allosteric binding site; other site 1162668000548 PUA domain; Region: PUA; pfam01472 1162668000549 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 1162668000550 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 1162668000551 putative catalytic cysteine [active] 1162668000552 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 1162668000553 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1162668000554 active site 1162668000555 (T/H)XGH motif; other site 1162668000556 Oligomerisation domain; Region: Oligomerisation; pfam02410 1162668000557 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1162668000558 binding surface 1162668000559 TPR motif; other site 1162668000560 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1162668000561 binding surface 1162668000562 TPR motif; other site 1162668000563 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1162668000564 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 1162668000565 ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747 1162668000566 DEAD/DEAH box helicase; Region: DEAD; pfam00270 1162668000567 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1162668000568 CHASE3 domain; Region: CHASE3; pfam05227 1162668000569 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1162668000570 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1162668000571 metal binding site [ion binding]; metal-binding site 1162668000572 active site 1162668000573 I-site; other site 1162668000574 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 1162668000575 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 1162668000576 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1162668000577 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1162668000578 homodimer interface [polypeptide binding]; other site 1162668000579 substrate-cofactor binding pocket; other site 1162668000580 catalytic residue [active] 1162668000581 5'-3' exonuclease; Region: 53EXOc; smart00475 1162668000582 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1162668000583 active site 1162668000584 metal binding site 1 [ion binding]; metal-binding site 1162668000585 putative 5' ssDNA interaction site; other site 1162668000586 metal binding site 3; metal-binding site 1162668000587 metal binding site 2 [ion binding]; metal-binding site 1162668000588 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1162668000589 putative DNA binding site [nucleotide binding]; other site 1162668000590 putative metal binding site [ion binding]; other site 1162668000591 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 1162668000592 bifunctional 3'-5' exonuclease/DNA polymerase; Provisional; Region: PRK14975 1162668000593 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1162668000594 active site 1162668000595 DNA binding site [nucleotide binding] 1162668000596 catalytic site [active] 1162668000597 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1162668000598 binding surface 1162668000599 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1162668000600 TPR motif; other site 1162668000601 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 1162668000602 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1162668000603 CoA-binding site [chemical binding]; other site 1162668000604 ATP-binding [chemical binding]; other site 1162668000605 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1162668000606 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1162668000607 active site 1162668000608 tetramer interface; other site 1162668000609 Thiamine monophosphate kinase [Coenzyme metabolism]; Region: ThiL; COG0611 1162668000610 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 1162668000611 ATP binding site [chemical binding]; other site 1162668000612 dimerization interface [polypeptide binding]; other site 1162668000613 Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; pfam09835 1162668000614 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1162668000615 ligand binding site [chemical binding]; other site 1162668000616 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1162668000617 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1162668000618 ligand binding site [chemical binding]; other site 1162668000619 ribonuclease R; Region: RNase_R; TIGR02063 1162668000620 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 1162668000621 RNB domain; Region: RNB; pfam00773 1162668000622 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 1162668000623 RNA binding site [nucleotide binding]; other site 1162668000624 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 1162668000625 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 1162668000626 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1162668000627 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1162668000628 Phosphoesterase family; Region: Phosphoesterase; pfam04185 1162668000629 Peroxiredoxin family protein [General function prediction only]; Region: COG2210 1162668000630 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 1162668000631 CPxP motif; other site 1162668000632 Domain of unknown function (DUF3391); Region: DUF3391; pfam11871 1162668000633 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1162668000634 Zn2+ binding site [ion binding]; other site 1162668000635 Mg2+ binding site [ion binding]; other site 1162668000636 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1162668000637 hypothetical protein; Provisional; Region: PRK07394 1162668000638 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1162668000639 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 1162668000640 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 1162668000641 homodimer interface [polypeptide binding]; other site 1162668000642 metal binding site [ion binding]; metal-binding site 1162668000643 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 1162668000644 homodimer interface [polypeptide binding]; other site 1162668000645 active site 1162668000646 putative chemical substrate binding site [chemical binding]; other site 1162668000647 metal binding site [ion binding]; metal-binding site 1162668000648 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 1162668000649 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1162668000650 Walker A motif; other site 1162668000651 ATP binding site [chemical binding]; other site 1162668000652 Walker B motif; other site 1162668000653 arginine finger; other site 1162668000654 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1162668000655 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1162668000656 nucleoside/Zn binding site; other site 1162668000657 dimer interface [polypeptide binding]; other site 1162668000658 catalytic motif [active] 1162668000659 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1162668000660 TPR motif; other site 1162668000661 binding surface 1162668000662 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1162668000663 TPR repeat; Region: TPR_11; pfam13414 1162668000664 binding surface 1162668000665 TPR motif; other site 1162668000666 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1162668000667 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 1162668000668 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 1162668000669 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 1162668000670 G1 box; other site 1162668000671 putative GEF interaction site [polypeptide binding]; other site 1162668000672 GTP/Mg2+ binding site [chemical binding]; other site 1162668000673 Switch I region; other site 1162668000674 G2 box; other site 1162668000675 G3 box; other site 1162668000676 Switch II region; other site 1162668000677 G4 box; other site 1162668000678 G5 box; other site 1162668000679 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 1162668000680 recombination protein RecR; Reviewed; Region: recR; PRK00076 1162668000681 RecR protein; Region: RecR; pfam02132 1162668000682 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1162668000683 putative active site [active] 1162668000684 putative metal-binding site [ion binding]; other site 1162668000685 tetramer interface [polypeptide binding]; other site 1162668000686 hypothetical protein; Validated; Region: PRK00153 1162668000687 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 1162668000688 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1162668000689 Walker A motif; other site 1162668000690 ATP binding site [chemical binding]; other site 1162668000691 Walker B motif; other site 1162668000692 arginine finger; other site 1162668000693 potential protein location (hypothetical protein LFE_0226 [Leptospirillum ferrooxidans C2-3]) that overlaps RNA (tRNA-S) 1162668000694 Outer membrane efflux protein; Region: OEP; pfam02321 1162668000695 Outer membrane efflux protein; Region: OEP; pfam02321 1162668000696 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 1162668000697 CPxP motif; other site 1162668000698 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: DUF374; Region: LPLAT_DUF374-like; cd07983 1162668000699 putative acyl-acceptor binding pocket; other site 1162668000700 Rad52/22 family double-strand break repair protein; Region: Rad52_Rad22; cl01936 1162668000701 Protein of unknown function (DUF1232); Region: DUF1232; pfam06803 1162668000702 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 1162668000703 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 1162668000704 HlyD family secretion protein; Region: HlyD_3; pfam13437 1162668000705 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 1162668000706 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 1162668000707 putative active site [active] 1162668000708 metal binding site [ion binding]; metal-binding site 1162668000709 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 1162668000710 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 1162668000711 classical (c) SDRs; Region: SDR_c; cd05233 1162668000712 NAD(P) binding site [chemical binding]; other site 1162668000713 active site 1162668000714 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1162668000715 binding surface 1162668000716 TPR motif; other site 1162668000717 diaminopimelate epimerase; Provisional; Region: PRK13577 1162668000718 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1162668000719 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1162668000720 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 1162668000721 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1162668000722 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1162668000723 S-adenosylmethionine binding site [chemical binding]; other site 1162668000724 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1162668000725 active site residue [active] 1162668000726 SurA N-terminal domain; Region: SurA_N_3; pfam13624 1162668000727 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; pfam02639 1162668000728 lipoyl synthase; Provisional; Region: PRK05481 1162668000729 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1162668000730 FeS/SAM binding site; other site 1162668000731 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 1162668000732 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 1162668000733 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1162668000734 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1162668000735 lipoyl attachment site [posttranslational modification]; other site 1162668000736 glycine dehydrogenase subunit 1; Validated; Region: PRK00451 1162668000737 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 1162668000738 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1162668000739 catalytic residue [active] 1162668000740 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1162668000741 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1162668000742 catalytic residue [active] 1162668000743 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1162668000744 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1162668000745 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 1162668000746 HDOD domain; Region: HDOD; pfam08668 1162668000747 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1162668000748 Zn2+ binding site [ion binding]; other site 1162668000749 Mg2+ binding site [ion binding]; other site 1162668000750 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 1162668000751 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 1162668000752 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 1162668000753 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1162668000754 Walker A motif; other site 1162668000755 ATP binding site [chemical binding]; other site 1162668000756 Walker B motif; other site 1162668000757 arginine finger; other site 1162668000758 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1162668000759 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 1162668000760 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1162668000761 binding surface 1162668000762 TPR motif; other site 1162668000763 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1162668000764 TPR motif; other site 1162668000765 binding surface 1162668000766 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1162668000767 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1162668000768 dimer interface [polypeptide binding]; other site 1162668000769 phosphorylation site [posttranslational modification] 1162668000770 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1162668000771 ATP binding site [chemical binding]; other site 1162668000772 Mg2+ binding site [ion binding]; other site 1162668000773 G-X-G motif; other site 1162668000774 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1162668000775 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1162668000776 active site 1162668000777 phosphorylation site [posttranslational modification] 1162668000778 intermolecular recognition site; other site 1162668000779 dimerization interface [polypeptide binding]; other site 1162668000780 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1162668000781 Walker A motif; other site 1162668000782 ATP binding site [chemical binding]; other site 1162668000783 Walker B motif; other site 1162668000784 arginine finger; other site 1162668000785 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1162668000786 Flagellar basal body protein [Cell motility and secretion]; Region: FlgB; COG1815 1162668000787 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 1162668000788 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 1162668000789 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1162668000790 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1162668000791 Flagellar hook-basal body complex protein FliE; Region: FliE; pfam02049 1162668000792 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 1162668000793 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 1162668000794 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 1162668000795 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 1162668000796 MgtE intracellular N domain; Region: MgtE_N; cl15244 1162668000797 FliG C-terminal domain; Region: FliG_C; pfam01706 1162668000798 Flagellar assembly protein FliH; Region: FliH; pfam02108 1162668000799 flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496 1162668000800 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 1162668000801 Walker A motif/ATP binding site; other site 1162668000802 Walker B motif; other site 1162668000803 flagellar export protein FliJ; Region: flagell_FliJ; TIGR02473 1162668000804 Uncharacterized conserved protein [Function unknown]; Region: COG3334 1162668000805 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 1162668000806 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 1162668000807 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 1162668000808 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 1162668000809 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 1162668000810 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1162668000811 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 1162668000812 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 1162668000813 Flagellar biosynthesis protein, FliO; Region: FliO; pfam04347 1162668000814 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 1162668000815 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 1162668000816 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 1162668000817 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 1162668000818 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 1162668000819 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 1162668000820 FHIPEP family; Region: FHIPEP; pfam00771 1162668000821 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 1162668000822 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1162668000823 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 1162668000824 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 1162668000825 P-loop; other site 1162668000826 RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479 1162668000827 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1162668000828 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1162668000829 DNA binding residues [nucleotide binding] 1162668000830 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 1162668000831 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1162668000832 active site 1162668000833 phosphorylation site [posttranslational modification] 1162668000834 intermolecular recognition site; other site 1162668000835 dimerization interface [polypeptide binding]; other site 1162668000836 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1162668000837 putative binding surface; other site 1162668000838 active site 1162668000839 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 1162668000840 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 1162668000841 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1162668000842 ATP binding site [chemical binding]; other site 1162668000843 Mg2+ binding site [ion binding]; other site 1162668000844 G-X-G motif; other site 1162668000845 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 1162668000846 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1162668000847 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1162668000848 dimerization interface [polypeptide binding]; other site 1162668000849 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1162668000850 dimer interface [polypeptide binding]; other site 1162668000851 putative CheW interface [polypeptide binding]; other site 1162668000852 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 1162668000853 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 1162668000854 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 1162668000855 flagellar motor protein MotD; Reviewed; Region: PRK09038 1162668000856 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 1162668000857 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1162668000858 ligand binding site [chemical binding]; other site 1162668000859 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 1162668000860 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 1162668000861 PIN domain; Region: PIN_3; pfam13470 1162668000862 LL-diaminopimelate aminotransferase; Provisional; Region: PRK09276 1162668000863 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1162668000864 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1162668000865 homodimer interface [polypeptide binding]; other site 1162668000866 catalytic residue [active] 1162668000867 A/G-specific adenine glycosylase; Region: mutY; TIGR01084 1162668000868 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1162668000869 minor groove reading motif; other site 1162668000870 helix-hairpin-helix signature motif; other site 1162668000871 substrate binding pocket [chemical binding]; other site 1162668000872 active site 1162668000873 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 1162668000874 Domain of unknown function (DUF3332); Region: DUF3332; pfam11810 1162668000875 ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986 1162668000876 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1162668000877 dimer interface [polypeptide binding]; other site 1162668000878 conserved gate region; other site 1162668000879 putative PBP binding loops; other site 1162668000880 ABC-ATPase subunit interface; other site 1162668000881 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1162668000882 dimer interface [polypeptide binding]; other site 1162668000883 conserved gate region; other site 1162668000884 putative PBP binding loops; other site 1162668000885 ABC-ATPase subunit interface; other site 1162668000886 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1162668000887 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1162668000888 Walker A/P-loop; other site 1162668000889 ATP binding site [chemical binding]; other site 1162668000890 Q-loop/lid; other site 1162668000891 ABC transporter signature motif; other site 1162668000892 Walker B; other site 1162668000893 D-loop; other site 1162668000894 H-loop/switch region; other site 1162668000895 ABC nitrate/sulfonate/bicarbonate family transporter, ATPase subunit; Region: ABC_transp; pfam09821 1162668000896 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 1162668000897 DNA protecting protein DprA; Region: dprA; TIGR00732 1162668000898 DNA topoisomerase I; Validated; Region: PRK06599 1162668000899 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1162668000900 active site 1162668000901 interdomain interaction site; other site 1162668000902 putative metal-binding site [ion binding]; other site 1162668000903 nucleotide binding site [chemical binding]; other site 1162668000904 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1162668000905 domain I; other site 1162668000906 DNA binding groove [nucleotide binding] 1162668000907 phosphate binding site [ion binding]; other site 1162668000908 domain II; other site 1162668000909 domain III; other site 1162668000910 nucleotide binding site [chemical binding]; other site 1162668000911 catalytic site [active] 1162668000912 domain IV; other site 1162668000913 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1162668000914 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1162668000915 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 1162668000916 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1162668000917 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1162668000918 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 1162668000919 Glucose inhibited division protein A; Region: GIDA; pfam01134 1162668000920 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 1162668000921 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1162668000922 active site 1162668000923 DNA binding site [nucleotide binding] 1162668000924 Int/Topo IB signature motif; other site 1162668000925 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 1162668000926 feedback inhibition sensing region; other site 1162668000927 homohexameric interface [polypeptide binding]; other site 1162668000928 nucleotide binding site [chemical binding]; other site 1162668000929 N-acetyl-L-glutamate binding site [chemical binding]; other site 1162668000930 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1162668000931 trimer interface [polypeptide binding]; other site 1162668000932 active site 1162668000933 Domain of unknown function (DUF3391); Region: DUF3391; pfam11871 1162668000934 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1162668000935 Zn2+ binding site [ion binding]; other site 1162668000936 Mg2+ binding site [ion binding]; other site 1162668000937 Outer membrane efflux protein; Region: OEP; pfam02321 1162668000938 Outer membrane efflux protein; Region: OEP; pfam02321 1162668000939 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1162668000940 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1162668000941 HlyD family secretion protein; Region: HlyD_3; pfam13437 1162668000942 Pantoate-beta-alanine ligase; Region: PanC; cd00560 1162668000943 pantoate--beta-alanine ligase; Region: panC; TIGR00018 1162668000944 active site 1162668000945 ATP-binding site [chemical binding]; other site 1162668000946 pantoate-binding site; other site 1162668000947 HXXH motif; other site 1162668000948 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 1162668000949 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1162668000950 Fic/DOC family N-terminal; Region: Fic_N; pfam13784 1162668000951 Fic family protein [Function unknown]; Region: COG3177 1162668000952 Fic/DOC family; Region: Fic; pfam02661 1162668000953 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1162668000954 homodimer interface [polypeptide binding]; other site 1162668000955 substrate-cofactor binding pocket; other site 1162668000956 Aminotransferase class IV; Region: Aminotran_4; pfam01063 1162668000957 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1162668000958 catalytic residue [active] 1162668000959 Uncharacterized conserved protein [Function unknown]; Region: COG3391 1162668000960 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 1162668000961 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1162668000962 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 1162668000963 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 1162668000964 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1162668000965 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1162668000966 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 1162668000967 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1162668000968 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1162668000969 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1162668000970 active site 1162668000971 phosphorylation site [posttranslational modification] 1162668000972 intermolecular recognition site; other site 1162668000973 dimerization interface [polypeptide binding]; other site 1162668000974 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1162668000975 DNA binding site [nucleotide binding] 1162668000976 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1162668000977 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1162668000978 transposase/IS protein; Provisional; Region: PRK09183 1162668000979 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1162668000980 Walker A motif; other site 1162668000981 ATP binding site [chemical binding]; other site 1162668000982 Walker B motif; other site 1162668000983 arginine finger; other site 1162668000984 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1162668000985 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 1162668000986 Integrase core domain; Region: rve; pfam00665 1162668000987 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1162668000988 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1162668000989 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1162668000990 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1162668000991 DsrE/DsrF/DrsH-like family; Region: DrsE_2; cl17453 1162668000992 Predicted membrane protein [Function unknown]; Region: COG2855 1162668000993 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1162668000994 HlyD family secretion protein; Region: HlyD_3; pfam13437 1162668000995 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1162668000996 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 1162668000997 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1162668000998 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1162668000999 metal binding site [ion binding]; metal-binding site 1162668001000 active site 1162668001001 I-site; other site 1162668001002 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1162668001003 Microscilla MS158 and related proteins, metallophosphatase domain; Region: MPP_MS158; cd07404 1162668001004 putative active site [active] 1162668001005 putative metal binding site [ion binding]; other site 1162668001006 Restriction endonuclease; Region: Mrr_cat; pfam04471 1162668001007 HsdM N-terminal domain; Region: HsdM_N; pfam12161 1162668001008 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 1162668001009 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1162668001010 Domain of unknown function (DUF4258); Region: DUF4258; pfam14076 1162668001011 antitoxin MqsA for MqsR toxin; Region: MqsA; cd12870 1162668001012 toxin interface [polypeptide binding]; other site 1162668001013 Zn binding site [ion binding]; other site 1162668001014 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1162668001015 dimerization interface [polypeptide binding]; other site 1162668001016 putative DNA binding site [nucleotide binding]; other site 1162668001017 putative Zn2+ binding site [ion binding]; other site 1162668001018 Protein of unknown function (DUF2971); Region: DUF2971; pfam11185 1162668001019 Nucleotidyltransferase substrate binding protein like; Region: NTase_sub_bind; pfam08780 1162668001020 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 1162668001021 active site 1162668001022 NTP binding site [chemical binding]; other site 1162668001023 metal binding triad [ion binding]; metal-binding site 1162668001024 antibiotic binding site [chemical binding]; other site 1162668001025 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 1162668001026 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1162668001027 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1162668001028 Domain of unknown function (DUF4145); Region: DUF4145; pfam13643 1162668001029 RelB antitoxin; Region: RelB; cl01171 1162668001030 Protein of unknown function (DUF1044); Region: DUF1044; cl01955 1162668001031 Protein of unknown function (DUF1044); Region: DUF1044; cl01955 1162668001032 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1162668001033 non-specific DNA binding site [nucleotide binding]; other site 1162668001034 salt bridge; other site 1162668001035 sequence-specific DNA binding site [nucleotide binding]; other site 1162668001036 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 1162668001037 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 1162668001038 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1162668001039 ATP binding site [chemical binding]; other site 1162668001040 putative Mg++ binding site [ion binding]; other site 1162668001041 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 1162668001042 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 1162668001043 Helix-turn-helix domain; Region: HTH_17; pfam12728 1162668001044 CHC2 zinc finger; Region: zf-CHC2; cl17510 1162668001045 Protein of unknown function (DUF3991); Region: DUF3991; pfam13154 1162668001046 Toprim-like; Region: Toprim_2; pfam13155 1162668001047 active site 1162668001048 metal binding site [ion binding]; metal-binding site 1162668001049 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 1162668001050 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1162668001051 Type IV secretion-system coupling protein DNA-binding domain; Region: TrwB_AAD_bind; pfam10412 1162668001052 Walker A motif; other site 1162668001053 ATP binding site [chemical binding]; other site 1162668001054 Walker B motif; other site 1162668001055 Domain of unknown function (DUF1738); Region: DUF1738; pfam08401 1162668001056 Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227 1162668001057 integrase; Provisional; Region: int; PHA02601 1162668001058 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1162668001059 active site 1162668001060 DNA binding site [nucleotide binding] 1162668001061 Int/Topo IB signature motif; other site 1162668001062 Domain of unknown function (DUF3391); Region: DUF3391; pfam11871 1162668001063 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 1162668001064 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1162668001065 Zn2+ binding site [ion binding]; other site 1162668001066 Mg2+ binding site [ion binding]; other site 1162668001067 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1162668001068 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1162668001069 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiB; COG0543 1162668001070 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 1162668001071 FAD binding pocket [chemical binding]; other site 1162668001072 conserved FAD binding motif [chemical binding]; other site 1162668001073 phosphate binding motif [ion binding]; other site 1162668001074 beta-alpha-beta structure motif; other site 1162668001075 NAD binding pocket [chemical binding]; other site 1162668001076 Predicted methyltransferases [General function prediction only]; Region: COG0313 1162668001077 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1162668001078 putative SAM binding site [chemical binding]; other site 1162668001079 putative homodimer interface [polypeptide binding]; other site 1162668001080 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1162668001081 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 1162668001082 active site 1162668001083 catalytic triad [active] 1162668001084 dimer interface [polypeptide binding]; other site 1162668001085 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 1162668001086 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1162668001087 S-adenosylmethionine binding site [chemical binding]; other site 1162668001088 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1162668001089 DNA binding residues [nucleotide binding] 1162668001090 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1162668001091 dimerization interface [polypeptide binding]; other site 1162668001092 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1162668001093 FeS/SAM binding site; other site 1162668001094 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 1162668001095 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 1162668001096 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 1162668001097 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1162668001098 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1162668001099 Walker A motif; other site 1162668001100 ATP binding site [chemical binding]; other site 1162668001101 Walker B motif; other site 1162668001102 arginine finger; other site 1162668001103 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1162668001104 Holliday junction resolvasome, DNA-binding subunit [DNA replication, recombination, and repair]; Region: RuvA; COG0632 1162668001105 RuvA N terminal domain; Region: RuvA_N; pfam01330 1162668001106 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cl17280 1162668001107 active site 1162668001108 putative DNA-binding cleft [nucleotide binding]; other site 1162668001109 dimer interface [polypeptide binding]; other site 1162668001110 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 1162668001111 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1162668001112 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1162668001113 protein binding site [polypeptide binding]; other site 1162668001114 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1162668001115 protein binding site [polypeptide binding]; other site 1162668001116 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1162668001117 active site 1162668001118 phosphorylation site [posttranslational modification] 1162668001119 intermolecular recognition site; other site 1162668001120 dimerization interface [polypeptide binding]; other site 1162668001121 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1162668001122 dimerization interface [polypeptide binding]; other site 1162668001123 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1162668001124 dimer interface [polypeptide binding]; other site 1162668001125 phosphorylation site [posttranslational modification] 1162668001126 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1162668001127 ATP binding site [chemical binding]; other site 1162668001128 Mg2+ binding site [ion binding]; other site 1162668001129 G-X-G motif; other site 1162668001130 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 1162668001131 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 1162668001132 trimer interface [polypeptide binding]; other site 1162668001133 putative metal binding site [ion binding]; other site 1162668001134 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 1162668001135 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1162668001136 motif II; other site 1162668001137 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 1162668001138 DsrE/DsrF-like family; Region: DrsE; pfam02635 1162668001139 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 1162668001140 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1162668001141 dimer interface [polypeptide binding]; other site 1162668001142 conserved gate region; other site 1162668001143 putative PBP binding loops; other site 1162668001144 ABC-ATPase subunit interface; other site 1162668001145 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1162668001146 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1162668001147 dimer interface [polypeptide binding]; other site 1162668001148 conserved gate region; other site 1162668001149 putative PBP binding loops; other site 1162668001150 ABC-ATPase subunit interface; other site 1162668001151 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 1162668001152 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1162668001153 homodimer interface [polypeptide binding]; other site 1162668001154 substrate-cofactor binding pocket; other site 1162668001155 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1162668001156 catalytic residue [active] 1162668001157 Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642 1162668001158 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 1162668001159 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 1162668001160 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1162668001161 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1162668001162 metal-binding site [ion binding] 1162668001163 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1162668001164 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1162668001165 metal-binding site [ion binding] 1162668001166 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1162668001167 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1162668001168 motif II; other site 1162668001169 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1162668001170 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1162668001171 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1162668001172 putative active site [active] 1162668001173 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033 1162668001174 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1162668001175 EamA-like transporter family; Region: EamA; pfam00892 1162668001176 Catalytic domain of EDTA-resistant nuclease Nuc, vertebrate phospholipase D6, and similar proteins; Region: PLDc_Nuc_like; cd09116 1162668001177 PLD-like domain; Region: PLDc_2; pfam13091 1162668001178 putative active site [active] 1162668001179 catalytic site [active] 1162668001180 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1162668001181 catalytic residues [active] 1162668001182 Peptidase family M1; Region: Peptidase_M1; pfam01433 1162668001183 Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601 1162668001184 Zn binding site [ion binding]; other site 1162668001185 Domain of unknown function (DUF3358); Region: DUF3358; pfam11838 1162668001186 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 1162668001187 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 1162668001188 hypothetical protein; Provisional; Region: PRK02237 1162668001189 excinuclease ABC subunit B; Provisional; Region: PRK05298 1162668001190 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1162668001191 ATP binding site [chemical binding]; other site 1162668001192 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1162668001193 nucleotide binding region [chemical binding]; other site 1162668001194 ATP-binding site [chemical binding]; other site 1162668001195 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1162668001196 UvrB/uvrC motif; Region: UVR; pfam02151 1162668001197 Domain of unknown function (DUF4321); Region: DUF4321; pfam14209 1162668001198 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 1162668001199 heme-binding site [chemical binding]; other site 1162668001200 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1162668001201 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1162668001202 putative active site [active] 1162668001203 heme pocket [chemical binding]; other site 1162668001204 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1162668001205 dimer interface [polypeptide binding]; other site 1162668001206 phosphorylation site [posttranslational modification] 1162668001207 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1162668001208 ATP binding site [chemical binding]; other site 1162668001209 Mg2+ binding site [ion binding]; other site 1162668001210 G-X-G motif; other site 1162668001211 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1162668001212 Response regulator receiver domain; Region: Response_reg; pfam00072 1162668001213 active site 1162668001214 phosphorylation site [posttranslational modification] 1162668001215 intermolecular recognition site; other site 1162668001216 dimerization interface [polypeptide binding]; other site 1162668001217 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1162668001218 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1162668001219 active site 1162668001220 phosphorylation site [posttranslational modification] 1162668001221 intermolecular recognition site; other site 1162668001222 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1162668001223 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1162668001224 metal binding site [ion binding]; metal-binding site 1162668001225 active site 1162668001226 I-site; other site 1162668001227 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1162668001228 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 1162668001229 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1162668001230 dimerization interface [polypeptide binding]; other site 1162668001231 putative DNA binding site [nucleotide binding]; other site 1162668001232 putative Zn2+ binding site [ion binding]; other site 1162668001233 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 1162668001234 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1162668001235 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1162668001236 HlyD family secretion protein; Region: HlyD_3; pfam13437 1162668001237 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1162668001238 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 1162668001239 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298 1162668001240 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_2; TIGR02822 1162668001241 putative NAD(P) binding site [chemical binding]; other site 1162668001242 putative substrate binding site [chemical binding]; other site 1162668001243 catalytic Zn binding site [ion binding]; other site 1162668001244 structural Zn binding site [ion binding]; other site 1162668001245 Domain of unknown function (DUF4399); Region: DUF4399; pfam14347 1162668001246 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1162668001247 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 1162668001248 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1162668001249 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1162668001250 catalytic triad [active] 1162668001251 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1162668001252 putative substrate translocation pore; other site 1162668001253 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1162668001254 Transcriptional activator [Transcription]; Region: ChrR; COG3806 1162668001255 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 1162668001256 GAF domain; Region: GAF_3; pfam13492 1162668001257 GAF domain; Region: GAF_2; pfam13185 1162668001258 PAS domain S-box; Region: sensory_box; TIGR00229 1162668001259 PAS domain; Region: PAS_8; pfam13188 1162668001260 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1162668001261 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1162668001262 metal binding site [ion binding]; metal-binding site 1162668001263 active site 1162668001264 I-site; other site 1162668001265 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1162668001266 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 1162668001267 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1162668001268 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 1162668001269 TPR motif; other site 1162668001270 binding surface 1162668001271 Bacitracin resistance protein BacA; Region: BacA; pfam02673 1162668001272 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08665 1162668001273 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 1162668001274 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 1162668001275 active site 1162668001276 dimer interface [polypeptide binding]; other site 1162668001277 effector binding site; other site 1162668001278 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 1162668001279 TSCPD domain; Region: TSCPD; cl14834 1162668001280 Rubrerythrin [Energy production and conversion]; Region: COG1592 1162668001281 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 1162668001282 binuclear metal center [ion binding]; other site 1162668001283 Protein of unknown function (DUF3897); Region: DUF3897; pfam13036 1162668001284 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3014 1162668001285 LPP20 lipoprotein; Region: LPP20; pfam02169 1162668001286 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1162668001287 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1162668001288 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1162668001289 dimer interface [polypeptide binding]; other site 1162668001290 putative CheW interface [polypeptide binding]; other site 1162668001291 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1162668001292 PAS domain; Region: PAS_9; pfam13426 1162668001293 putative active site [active] 1162668001294 heme pocket [chemical binding]; other site 1162668001295 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1162668001296 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1162668001297 metal binding site [ion binding]; metal-binding site 1162668001298 active site 1162668001299 I-site; other site 1162668001300 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1162668001301 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 1162668001302 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 1162668001303 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 1162668001304 Ligand Binding Site [chemical binding]; other site 1162668001305 TIGR00269 family protein; Region: TIGR00269 1162668001306 Protein of unknown function (DUF721); Region: DUF721; pfam05258 1162668001307 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 1162668001308 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1162668001309 active site 1162668001310 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 1162668001311 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 1162668001312 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1162668001313 DNA polymerase III, delta subunit; Region: holA; TIGR01128 1162668001314 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 1162668001315 Lipopolysaccharide-assembly; Region: LptE; pfam04390 1162668001316 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1162668001317 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1162668001318 HIGH motif; other site 1162668001319 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1162668001320 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1162668001321 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1162668001322 active site 1162668001323 KMSKS motif; other site 1162668001324 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1162668001325 tRNA binding surface [nucleotide binding]; other site 1162668001326 Winged helix-turn helix; Region: HTH_29; pfam13551 1162668001327 Homeodomain-like domain; Region: HTH_32; pfam13565 1162668001328 Integrase core domain; Region: rve; pfam00665 1162668001329 Integrase core domain; Region: rve_3; pfam13683 1162668001330 Transposase; Region: HTH_Tnp_1; cl17663 1162668001331 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1162668001332 MPT binding site; other site 1162668001333 trimer interface [polypeptide binding]; other site 1162668001334 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 1162668001335 trimer interface [polypeptide binding]; other site 1162668001336 dimer interface [polypeptide binding]; other site 1162668001337 putative active site [active] 1162668001338 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1162668001339 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1162668001340 dimer interface [polypeptide binding]; other site 1162668001341 putative functional site; other site 1162668001342 putative MPT binding site; other site 1162668001343 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 1162668001344 MoaE homodimer interface [polypeptide binding]; other site 1162668001345 MoaD interaction [polypeptide binding]; other site 1162668001346 active site residues [active] 1162668001347 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1162668001348 MoaE interaction surface [polypeptide binding]; other site 1162668001349 MoeB interaction surface [polypeptide binding]; other site 1162668001350 thiocarboxylated glycine; other site 1162668001351 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1162668001352 FeS/SAM binding site; other site 1162668001353 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1162668001354 Nitrogen regulatory protein P-II; Region: P-II; pfam00543 1162668001355 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1162668001356 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 1162668001357 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1162668001358 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1162668001359 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 1162668001360 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1162668001361 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1162668001362 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 1162668001363 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1162668001364 putative substrate translocation pore; other site 1162668001365 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 1162668001366 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1162668001367 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cd00321 1162668001368 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 1162668001369 Moco binding site; other site 1162668001370 metal coordination site [ion binding]; other site 1162668001371 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 1162668001372 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1162668001373 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1162668001374 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 1162668001375 Probable transposase; Region: OrfB_IS605; pfam01385 1162668001376 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1162668001377 PBP superfamily domain; Region: PBP_like_2; cl17296 1162668001378 putative addiction module killer protein; Region: upstrm_HI1419; TIGR02683 1162668001379 probable addiction module antidote protein; Region: dnstrm_HI1420; TIGR02684 1162668001380 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1162668001381 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1162668001382 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1162668001383 metal binding site [ion binding]; metal-binding site 1162668001384 active site 1162668001385 I-site; other site 1162668001386 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1162668001387 metal binding site [ion binding]; metal-binding site 1162668001388 active site 1162668001389 I-site; other site 1162668001390 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1162668001391 methionine sulfoxide reductase A; Provisional; Region: PRK14054 1162668001392 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1162668001393 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD_like; cd08296 1162668001394 putative NAD(P) binding site [chemical binding]; other site 1162668001395 putative substrate binding site [chemical binding]; other site 1162668001396 catalytic Zn binding site [ion binding]; other site 1162668001397 structural Zn binding site [ion binding]; other site 1162668001398 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1162668001399 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1162668001400 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1162668001401 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1162668001402 S-adenosylmethionine binding site [chemical binding]; other site 1162668001403 TRL-like protein family; Region: TRL; pfam13146 1162668001404 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 1162668001405 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 1162668001406 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1162668001407 Walker A motif; other site 1162668001408 ATP binding site [chemical binding]; other site 1162668001409 Walker B motif; other site 1162668001410 pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519 1162668001411 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1162668001412 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 1162668001413 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1162668001414 Walker A motif; other site 1162668001415 ATP binding site [chemical binding]; other site 1162668001416 Walker B motif; other site 1162668001417 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 1162668001418 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1162668001419 Domain of unknown function (DUF202); Region: DUF202; pfam02656 1162668001420 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1162668001421 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1162668001422 dimer interface [polypeptide binding]; other site 1162668001423 putative CheW interface [polypeptide binding]; other site 1162668001424 Predicted membrane protein [Function unknown]; Region: COG1950 1162668001425 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14314 1162668001426 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1162668001427 active site 1162668001428 substrate binding site [chemical binding]; other site 1162668001429 metal binding site [ion binding]; metal-binding site 1162668001430 Competence protein; Region: Competence; pfam03772 1162668001431 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 1162668001432 DNA methylase; Region: N6_N4_Mtase; cl17433 1162668001433 DNA methylase; Region: N6_N4_Mtase; cl17433 1162668001434 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 1162668001435 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 1162668001436 putative dimer interface [polypeptide binding]; other site 1162668001437 [2Fe-2S] cluster binding site [ion binding]; other site 1162668001438 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 1162668001439 SLBB domain; Region: SLBB; pfam10531 1162668001440 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 1162668001441 P22-like integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial and phage integrases, including those similar to phage P22-like integrases, DLP12 and APSE-1; Region: INT_P22_C; cd01192 1162668001442 Int/Topo IB signature motif; other site 1162668001443 Helix-turn-helix domain; Region: HTH_17; pfam12728 1162668001444 potential protein location (hypothetical protein LFE_0526 [Leptospirillum ferrooxidans C2-3]) that overlaps RNA (tRNA-S) 1162668001445 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 1162668001446 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 1162668001447 Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; pfam09907 1162668001448 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1162668001449 non-specific DNA binding site [nucleotide binding]; other site 1162668001450 salt bridge; other site 1162668001451 sequence-specific DNA binding site [nucleotide binding]; other site 1162668001452 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 1162668001453 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 1162668001454 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1162668001455 non-specific DNA binding site [nucleotide binding]; other site 1162668001456 salt bridge; other site 1162668001457 sequence-specific DNA binding site [nucleotide binding]; other site 1162668001458 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1162668001459 Catalytic site [active] 1162668001460 Uncharacterized protein conserved in bacteria, prophage-related [Function unknown]; Region: COG4197 1162668001461 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1162668001462 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1162668001463 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1162668001464 dimer interface [polypeptide binding]; other site 1162668001465 ssDNA binding site [nucleotide binding]; other site 1162668001466 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1162668001467 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1162668001468 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1162668001469 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1162668001470 catalytic residue [active] 1162668001471 Protein of unknown function (DUF3625); Region: DUF3625; pfam12293 1162668001472 Bacterial conjugation TrbI-like protein; Region: TrbI; cl04242 1162668001473 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 1162668001474 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 1162668001475 HD domain; Region: HD_3; cl17350 1162668001476 Catalytic domain of EDTA-resistant nuclease Nuc, vertebrate phospholipase D6, and similar proteins; Region: PLDc_Nuc_like; cd09116 1162668001477 PLD-like domain; Region: PLDc_2; pfam13091 1162668001478 putative active site [active] 1162668001479 catalytic site [active] 1162668001480 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 1162668001481 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1162668001482 Type IV secretion-system coupling protein DNA-binding domain; Region: TrwB_AAD_bind; pfam10412 1162668001483 Walker A motif; other site 1162668001484 ATP binding site [chemical binding]; other site 1162668001485 Walker B motif; other site 1162668001486 TrwC relaxase; Region: TrwC; pfam08751 1162668001487 conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686 1162668001488 AAA domain; Region: AAA_30; pfam13604 1162668001489 Family description; Region: UvrD_C_2; pfam13538 1162668001490 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1162668001491 Domain of unknown function (DUF4263); Region: DUF4263; pfam14082 1162668001492 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1162668001493 Dot/Icm secretion system ATPase DotB; Region: dot_icm_DotB; TIGR02524 1162668001494 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1162668001495 Walker A motif; other site 1162668001496 ATP binding site [chemical binding]; other site 1162668001497 Walker B motif; other site 1162668001498 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 1162668001499 PRTRC system protein D; Region: PRTRC_D; TIGR03739 1162668001500 Mg binding site [ion binding]; other site 1162668001501 nucleotide binding site [chemical binding]; other site 1162668001502 putative protofilament interface [polypeptide binding]; other site 1162668001503 Toxin co-regulated pilus biosynthesis protein Q; Region: TcpQ; pfam10671 1162668001504 pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519 1162668001505 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1162668001506 Pilin accessory protein (PilO); Region: PAP_PilO; pfam06864 1162668001507 type IV pilus biogenesis protein PilP; Region: pilP_fam; TIGR03021 1162668001508 Type II/IV secretion system protein; Region: T2SE; pfam00437 1162668001509 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1162668001510 Walker A motif; other site 1162668001511 ATP binding site [chemical binding]; other site 1162668001512 Walker B motif; other site 1162668001513 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1162668001514 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1162668001515 PilS N terminal; Region: PilS; pfam08805 1162668001516 PilM; Region: PilM; pfam07419 1162668001517 Bacterial shufflon protein, N-terminal constant region; Region: Shufflon_N; pfam04917 1162668001518 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1162668001519 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1162668001520 active site 1162668001521 Int/Topo IB signature motif; other site 1162668001522 DNA binding site [nucleotide binding] 1162668001523 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 1162668001524 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1162668001525 Zn2+ binding site [ion binding]; other site 1162668001526 Mg2+ binding site [ion binding]; other site 1162668001527 GAF domain; Region: GAF; pfam01590 1162668001528 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1162668001529 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1162668001530 metal binding site [ion binding]; metal-binding site 1162668001531 active site 1162668001532 I-site; other site 1162668001533 PAS domain; Region: PAS_9; pfam13426 1162668001534 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1162668001535 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1162668001536 dimer interface [polypeptide binding]; other site 1162668001537 putative CheW interface [polypeptide binding]; other site 1162668001538 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 1162668001539 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 1162668001540 GIY-YIG motif/motif A; other site 1162668001541 active site 1162668001542 catalytic site [active] 1162668001543 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 1162668001544 heme-binding site [chemical binding]; other site 1162668001545 PAS domain; Region: PAS; smart00091 1162668001546 PAS fold; Region: PAS; pfam00989 1162668001547 PAS domain S-box; Region: sensory_box; TIGR00229 1162668001548 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1162668001549 putative active site [active] 1162668001550 heme pocket [chemical binding]; other site 1162668001551 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1162668001552 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1162668001553 metal binding site [ion binding]; metal-binding site 1162668001554 active site 1162668001555 I-site; other site 1162668001556 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1162668001557 HDOD domain; Region: HDOD; pfam08668 1162668001558 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1162668001559 Zn2+ binding site [ion binding]; other site 1162668001560 Mg2+ binding site [ion binding]; other site 1162668001561 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1162668001562 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1162668001563 putative active site [active] 1162668001564 heme pocket [chemical binding]; other site 1162668001565 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1162668001566 putative active site [active] 1162668001567 heme pocket [chemical binding]; other site 1162668001568 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1162668001569 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1162668001570 metal binding site [ion binding]; metal-binding site 1162668001571 active site 1162668001572 I-site; other site 1162668001573 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1162668001574 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1162668001575 TRL-like protein family; Region: TRL; pfam13146 1162668001576 Macrophage killing protein with similarity to conjugation protein; Region: IcmL; pfam11393 1162668001577 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 1162668001578 MPN+ (JAMM) motif; other site 1162668001579 Zinc-binding site [ion binding]; other site 1162668001580 TPR repeat; Region: TPR_11; pfam13414 1162668001581 Tetratricopeptide repeat; Region: TPR_2; pfam07719 1162668001582 DNA topoisomerase III; Provisional; Region: PRK07726 1162668001583 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 1162668001584 active site 1162668001585 putative interdomain interaction site [polypeptide binding]; other site 1162668001586 putative metal-binding site [ion binding]; other site 1162668001587 putative nucleotide binding site [chemical binding]; other site 1162668001588 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cl11986 1162668001589 domain I; other site 1162668001590 DNA binding groove [nucleotide binding] 1162668001591 phosphate binding site [ion binding]; other site 1162668001592 domain II; other site 1162668001593 domain III; other site 1162668001594 nucleotide binding site [chemical binding]; other site 1162668001595 catalytic site [active] 1162668001596 domain IV; other site 1162668001597 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1162668001598 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 1162668001599 conjugal transfer/type IV secretion protein DotA/TraY; Region: DotA_TraY; TIGR04346 1162668001600 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 1162668001601 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 1162668001602 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1162668001603 ATP binding site [chemical binding]; other site 1162668001604 putative Mg++ binding site [ion binding]; other site 1162668001605 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 1162668001606 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1162668001607 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1162668001608 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1162668001609 HsdM N-terminal domain; Region: HsdM_N; pfam12161 1162668001610 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 1162668001611 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1162668001612 S-adenosylmethionine binding site [chemical binding]; other site 1162668001613 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 1162668001614 AAA-like domain; Region: AAA_10; pfam12846 1162668001615 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470 1162668001616 catalytic tetrad [active] 1162668001617 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470 1162668001618 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 1162668001619 Probable transposase; Region: OrfB_IS605; pfam01385 1162668001620 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1162668001621 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 1162668001622 Predicted RNA binding protein (dsRBD-like fold), HicA family [General function prediction only]; Region: COG1724 1162668001623 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 1162668001624 methionine sulfoxide reductase B; Provisional; Region: PRK00222 1162668001625 SelR domain; Region: SelR; pfam01641 1162668001626 YbbR-like protein; Region: YbbR; pfam07949 1162668001627 Uncharacterized conserved protein [Function unknown]; Region: COG1624 1162668001628 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 1162668001629 dihydropteroate synthase; Region: DHPS; TIGR01496 1162668001630 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 1162668001631 substrate binding pocket [chemical binding]; other site 1162668001632 dimer interface [polypeptide binding]; other site 1162668001633 inhibitor binding site; inhibition site 1162668001634 FtsH Extracellular; Region: FtsH_ext; pfam06480 1162668001635 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1162668001636 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1162668001637 Walker A motif; other site 1162668001638 ATP binding site [chemical binding]; other site 1162668001639 Walker B motif; other site 1162668001640 arginine finger; other site 1162668001641 Peptidase family M41; Region: Peptidase_M41; pfam01434 1162668001642 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1162668001643 active site 1162668001644 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 1162668001645 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1162668001646 Ligand Binding Site [chemical binding]; other site 1162668001647 TilS substrate C-terminal domain; Region: TilS_C; smart00977 1162668001648 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 1162668001649 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1162668001650 active site 1162668001651 Riboflavin kinase; Region: Flavokinase; pfam01687 1162668001652 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 1162668001653 dimer interface [polypeptide binding]; other site 1162668001654 active site 1162668001655 Schiff base residues; other site 1162668001656 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1162668001657 active site 1162668001658 SAM binding site [chemical binding]; other site 1162668001659 homodimer interface [polypeptide binding]; other site 1162668001660 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 1162668001661 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1162668001662 active site 1162668001663 Pirin-related protein [General function prediction only]; Region: COG1741 1162668001664 Pirin; Region: Pirin; pfam02678 1162668001665 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 1162668001666 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 1162668001667 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 1162668001668 domain interfaces; other site 1162668001669 active site 1162668001670 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 1162668001671 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 1162668001672 tRNA; other site 1162668001673 putative tRNA binding site [nucleotide binding]; other site 1162668001674 putative NADP binding site [chemical binding]; other site 1162668001675 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 1162668001676 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 1162668001677 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 1162668001678 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 1162668001679 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1162668001680 FeS/SAM binding site; other site 1162668001681 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 1162668001682 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145 1162668001683 putative FMN binding site [chemical binding]; other site 1162668001684 2'-deoxycytidine 5'-triphosphate deaminase; Provisional; Region: PRK07559 1162668001685 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cl00493 1162668001686 trimer interface [polypeptide binding]; other site 1162668001687 active site 1162668001688 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cl00493 1162668001689 trimer interface [polypeptide binding]; other site 1162668001690 active site 1162668001691 proteasome ATPase; Region: pup_AAA; TIGR03689 1162668001692 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1162668001693 Walker A motif; other site 1162668001694 ATP binding site [chemical binding]; other site 1162668001695 Walker B motif; other site 1162668001696 arginine finger; other site 1162668001697 Pup-ligase protein; Region: Pup_ligase; pfam03136 1162668001698 proteasome, beta subunit, bacterial type; Region: 20S_bact_beta; TIGR03690 1162668001699 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 1162668001700 active site 1162668001701 proteasome, alpha subunit, bacterial type; Region: 20S_bact_alpha; TIGR03691 1162668001702 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 1162668001703 Pup-ligase protein; Region: Pup_ligase; pfam03136 1162668001704 Dihydroorotate dehydrogenase (DHOD) and Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the...; Region: DHOD_DHPD_FMN; cd02810 1162668001705 active site 1162668001706 FMN binding site [chemical binding]; other site 1162668001707 substrate binding site [chemical binding]; other site 1162668001708 Homoserine kinase [Amino acid transport and metabolism]; Region: ThrB; COG0083 1162668001709 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1162668001710 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 1162668001711 dimer interface [polypeptide binding]; other site 1162668001712 [2Fe-2S] cluster binding site [ion binding]; other site 1162668001713 VIT family; Region: VIT1; pfam01988 1162668001714 Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; cl01130 1162668001715 putative bifunctional cbb3-type cytochrome c oxidase subunit II/cytochrome c; Provisional; Region: PRK14486 1162668001716 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 1162668001717 Putative water exit pathway; other site 1162668001718 Putative proton exit pathway; other site 1162668001719 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 1162668001720 Uncharacterized conserved protein [Function unknown]; Region: COG1262 1162668001721 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 1162668001722 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 1162668001723 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 1162668001724 Protein of unknown function (DUF420); Region: DUF420; pfam04238 1162668001725 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1162668001726 dimer interface [polypeptide binding]; other site 1162668001727 ADP-ribose binding site [chemical binding]; other site 1162668001728 active site 1162668001729 nudix motif; other site 1162668001730 metal binding site [ion binding]; metal-binding site 1162668001731 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1162668001732 PAS fold; Region: PAS_4; pfam08448 1162668001733 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1162668001734 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1162668001735 Walker A motif; other site 1162668001736 ATP binding site [chemical binding]; other site 1162668001737 Walker B motif; other site 1162668001738 arginine finger; other site 1162668001739 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1162668001740 anthranilate synthase component I, non-proteobacterial lineages; Region: trpE_most; TIGR00564 1162668001741 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1162668001742 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1162668001743 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 1162668001744 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1162668001745 glutamine binding [chemical binding]; other site 1162668001746 catalytic triad [active] 1162668001747 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 1162668001748 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1162668001749 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1162668001750 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1162668001751 active site 1162668001752 product (indole) binding pocket [chemical binding]; other site 1162668001753 substrate (anthranilate) binding pocket [chemical binding]; other site 1162668001754 ribulose/triose binding site [chemical binding]; other site 1162668001755 phosphate binding site [ion binding]; other site 1162668001756 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 1162668001757 active site 1162668001758 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 1162668001759 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1162668001760 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1162668001761 catalytic residue [active] 1162668001762 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 1162668001763 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1162668001764 substrate binding site [chemical binding]; other site 1162668001765 active site 1162668001766 catalytic residues [active] 1162668001767 heterodimer interface [polypeptide binding]; other site 1162668001768 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 1162668001769 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1162668001770 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 1162668001771 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1162668001772 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 1162668001773 OstA-like protein; Region: OstA; cl00844 1162668001774 Organic solvent tolerance protein; Region: OstA_C; pfam04453 1162668001775 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 1162668001776 active site 1162668001777 Zn binding site [ion binding]; other site 1162668001778 NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255 1162668001779 ATP-NAD kinase; Region: NAD_kinase; pfam01513 1162668001780 putative glutamate synthase (NADPH) small subunit; Provisional; Region: PRK12771 1162668001781 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1162668001782 4Fe-4S binding domain; Region: Fer4; pfam00037 1162668001783 4Fe-4S binding domain; Region: Fer4; pfam00037 1162668001784 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 1162668001785 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1162668001786 iron-sulfur cluster [ion binding]; other site 1162668001787 [2Fe-2S] cluster binding site [ion binding]; other site 1162668001788 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 1162668001789 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 1162668001790 heme bH binding site [chemical binding]; other site 1162668001791 intrachain domain interface; other site 1162668001792 Qi binding site; other site 1162668001793 heme bL binding site [chemical binding]; other site 1162668001794 interchain domain interface [polypeptide binding]; other site 1162668001795 Qo binding site; other site 1162668001796 decaheme c-type cytochrome, OmcA/MtrC family; Region: decahem_SO1788; TIGR03507 1162668001797 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1162668001798 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1162668001799 Walker A/P-loop; other site 1162668001800 ATP binding site [chemical binding]; other site 1162668001801 Q-loop/lid; other site 1162668001802 ABC transporter signature motif; other site 1162668001803 Walker B; other site 1162668001804 D-loop; other site 1162668001805 H-loop/switch region; other site 1162668001806 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1162668001807 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1162668001808 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 1162668001809 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 1162668001810 Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616 1162668001811 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 1162668001812 oligomer interface [polypeptide binding]; other site 1162668001813 tandem repeat interface [polypeptide binding]; other site 1162668001814 active site residues [active] 1162668001815 Domain of unknown function (DUF4147); Region: DUF4147; pfam13660 1162668001816 Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379 1162668001817 MOFRL family; Region: MOFRL; pfam05161 1162668001818 Uncharacterized conserved protein [Function unknown]; Region: COG1565 1162668001819 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1162668001820 Ribosomal protein L35Ae; Region: Ribosomal_L35Ae; cl01033 1162668001821 Predicted membrane protein (DUF2127); Region: DUF2127; pfam09900 1162668001822 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1162668001823 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1162668001824 putative substrate translocation pore; other site 1162668001825 FOG: CBS domain [General function prediction only]; Region: COG0517 1162668001826 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1162668001827 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 1162668001828 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1162668001829 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 1162668001830 nucleotide binding site/active site [active] 1162668001831 HIT family signature motif; other site 1162668001832 catalytic residue [active] 1162668001833 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 1162668001834 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1162668001835 active site 1162668001836 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 1162668001837 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1162668001838 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1162668001839 dihydroorotase; Validated; Region: pyrC; PRK09357 1162668001840 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1162668001841 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 1162668001842 active site 1162668001843 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1162668001844 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 1162668001845 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1162668001846 catalytic site [active] 1162668001847 subunit interface [polypeptide binding]; other site 1162668001848 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1162668001849 FeS/SAM binding site; other site 1162668001850 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1162668001851 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1162668001852 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1162668001853 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1162668001854 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1162668001855 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1162668001856 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1162668001857 IMP binding site; other site 1162668001858 dimer interface [polypeptide binding]; other site 1162668001859 partial ornithine binding site; other site 1162668001860 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1162668001861 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1162668001862 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1162668001863 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 1162668001864 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1162668001865 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1162668001866 catalytic residue [active] 1162668001867 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1162668001868 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1162668001869 metal binding site [ion binding]; metal-binding site 1162668001870 active site 1162668001871 I-site; other site 1162668001872 dihydrolipoamide dehydrogenase; Validated; Region: PRK06292 1162668001873 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1162668001874 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1162668001875 glutamine synthetase, type I; Region: GlnA; TIGR00653 1162668001876 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1162668001877 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1162668001878 Nif-specific regulatory protein; Region: nifA; TIGR01817 1162668001879 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1162668001880 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1162668001881 Walker A motif; other site 1162668001882 ATP binding site [chemical binding]; other site 1162668001883 Walker B motif; other site 1162668001884 arginine finger; other site 1162668001885 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1162668001886 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1162668001887 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1162668001888 dimer interface [polypeptide binding]; other site 1162668001889 anticodon binding site; other site 1162668001890 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1162668001891 homodimer interface [polypeptide binding]; other site 1162668001892 motif 1; other site 1162668001893 active site 1162668001894 motif 2; other site 1162668001895 GAD domain; Region: GAD; pfam02938 1162668001896 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1162668001897 active site 1162668001898 motif 3; other site 1162668001899 GMP synthase; Reviewed; Region: guaA; PRK00074 1162668001900 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1162668001901 AMP/PPi binding site [chemical binding]; other site 1162668001902 candidate oxyanion hole; other site 1162668001903 catalytic triad [active] 1162668001904 potential glutamine specificity residues [chemical binding]; other site 1162668001905 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1162668001906 ATP Binding subdomain [chemical binding]; other site 1162668001907 Ligand Binding sites [chemical binding]; other site 1162668001908 Dimerization subdomain; other site 1162668001909 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 1162668001910 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1162668001911 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 1162668001912 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1162668001913 active site 1162668001914 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1162668001915 Walker A motif; other site 1162668001916 ATP binding site [chemical binding]; other site 1162668001917 Walker B motif; other site 1162668001918 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 1162668001919 peptide chain release factor 2; Validated; Region: prfB; PRK00578 1162668001920 PCRF domain; Region: PCRF; pfam03462 1162668001921 RF-1 domain; Region: RF-1; pfam00472 1162668001922 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 1162668001923 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 1162668001924 putative active site [active] 1162668001925 catalytic triad [active] 1162668001926 putative dimer interface [polypeptide binding]; other site 1162668001927 ATP-dependent DNA ligase; Provisional; Region: PRK01109 1162668001928 Adenylation domain of proteins similar to ATP-dependent polynucleotide ligases; Region: Adenylation_DNA_ligase_like; cl12015 1162668001929 active site 1162668001930 The Oligonucleotide/oligosaccharide binding (OB)-fold domain is a DNA-binding module that is part of the catalytic core unit of ATP dependent DNA ligases; Region: OBF_DNA_ligase; cd07893 1162668001931 DNA binding site [nucleotide binding] 1162668001932 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1162668001933 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1162668001934 putative dimer interface [polypeptide binding]; other site 1162668001935 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 1162668001936 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1162668001937 Walker A motif; other site 1162668001938 ATP binding site [chemical binding]; other site 1162668001939 Walker B motif; other site 1162668001940 arginine finger; other site 1162668001941 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1162668001942 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 1162668001943 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1162668001944 minor groove reading motif; other site 1162668001945 helix-hairpin-helix signature motif; other site 1162668001946 substrate binding pocket [chemical binding]; other site 1162668001947 active site 1162668001948 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 1162668001949 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 1162668001950 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 1162668001951 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 1162668001952 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1162668001953 dimer interface [polypeptide binding]; other site 1162668001954 motif 1; other site 1162668001955 active site 1162668001956 motif 2; other site 1162668001957 motif 3; other site 1162668001958 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1162668001959 anticodon binding site; other site 1162668001960 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 1162668001961 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 1162668001962 GTP-binding protein LepA; Provisional; Region: PRK05433 1162668001963 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1162668001964 G1 box; other site 1162668001965 putative GEF interaction site [polypeptide binding]; other site 1162668001966 GTP/Mg2+ binding site [chemical binding]; other site 1162668001967 Switch I region; other site 1162668001968 G2 box; other site 1162668001969 G3 box; other site 1162668001970 Switch II region; other site 1162668001971 G4 box; other site 1162668001972 G5 box; other site 1162668001973 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1162668001974 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1162668001975 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1162668001976 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1162668001977 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1162668001978 Catalytic site [active] 1162668001979 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 1162668001980 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1162668001981 putative ribose interaction site [chemical binding]; other site 1162668001982 putative ADP binding site [chemical binding]; other site 1162668001983 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 1162668001984 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 1162668001985 Ligand binding site; other site 1162668001986 oligomer interface; other site 1162668001987 CTP synthetase; Validated; Region: pyrG; PRK05380 1162668001988 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1162668001989 Catalytic site [active] 1162668001990 active site 1162668001991 UTP binding site [chemical binding]; other site 1162668001992 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1162668001993 active site 1162668001994 putative oxyanion hole; other site 1162668001995 catalytic triad [active] 1162668001996 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 1162668001997 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1162668001998 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 1162668001999 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 1162668002000 putative active site [active] 1162668002001 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 1162668002002 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1162668002003 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 1162668002004 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 1162668002005 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 1162668002006 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1162668002007 Peptidase family M23; Region: Peptidase_M23; pfam01551 1162668002008 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1162668002009 dimerization interface [polypeptide binding]; other site 1162668002010 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1162668002011 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1162668002012 dimer interface [polypeptide binding]; other site 1162668002013 phosphorylation site [posttranslational modification] 1162668002014 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1162668002015 ATP binding site [chemical binding]; other site 1162668002016 Mg2+ binding site [ion binding]; other site 1162668002017 G-X-G motif; other site 1162668002018 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1162668002019 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1162668002020 active site 1162668002021 phosphorylation site [posttranslational modification] 1162668002022 intermolecular recognition site; other site 1162668002023 dimerization interface [polypeptide binding]; other site 1162668002024 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1162668002025 Walker A motif; other site 1162668002026 ATP binding site [chemical binding]; other site 1162668002027 Walker B motif; other site 1162668002028 arginine finger; other site 1162668002029 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1162668002030 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1162668002031 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 1162668002032 active site 1162668002033 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1162668002034 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 1162668002035 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1162668002036 FeS/SAM binding site; other site 1162668002037 Subunit B of Class III Extradiol ring-cleavage dioxygenases; Region: Extradiol_Dioxygenase_3B_like; cl00599 1162668002038 metal binding site [ion binding]; metal-binding site 1162668002039 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 1162668002040 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 1162668002041 Low-spin heme binding site [chemical binding]; other site 1162668002042 D-pathway; other site 1162668002043 Putative water exit pathway; other site 1162668002044 Binuclear center (active site) [active] 1162668002045 K-pathway; other site 1162668002046 Putative proton exit pathway; other site 1162668002047 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 1162668002048 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 1162668002049 heme-binding site [chemical binding]; other site 1162668002050 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 1162668002051 isocitrate dehydrogenase; Validated; Region: PRK06451 1162668002052 isocitrate dehydrogenase; Validated; Region: PRK09222 1162668002053 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1162668002054 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1162668002055 active site 1162668002056 phosphorylation site [posttranslational modification] 1162668002057 intermolecular recognition site; other site 1162668002058 dimerization interface [polypeptide binding]; other site 1162668002059 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1162668002060 Walker A motif; other site 1162668002061 ATP binding site [chemical binding]; other site 1162668002062 Walker B motif; other site 1162668002063 arginine finger; other site 1162668002064 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1162668002065 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1162668002066 GAF domain; Region: GAF; pfam01590 1162668002067 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1162668002068 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1162668002069 putative active site [active] 1162668002070 heme pocket [chemical binding]; other site 1162668002071 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1162668002072 dimer interface [polypeptide binding]; other site 1162668002073 phosphorylation site [posttranslational modification] 1162668002074 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1162668002075 ATP binding site [chemical binding]; other site 1162668002076 Mg2+ binding site [ion binding]; other site 1162668002077 G-X-G motif; other site 1162668002078 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 1162668002079 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3002 1162668002080 NADH dehydrogenase subunit L; Provisional; Region: PRK08168 1162668002081 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1162668002082 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1162668002083 binding surface 1162668002084 TPR motif; other site 1162668002085 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1162668002086 TPR motif; other site 1162668002087 binding surface 1162668002088 Predicted integral membrane protein [Function unknown]; Region: COG5616 1162668002089 TM1410 hypothetical-related protein; Region: DUF297; pfam03537 1162668002090 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 1162668002091 GAF domain; Region: GAF_3; pfam13492 1162668002092 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_3; cd03813 1162668002093 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1162668002094 Predicted membrane protein [Function unknown]; Region: COG4267 1162668002095 C-terminal Putative NodB-like catalytic domain of PelA-like uncharacterized hypothetical proteins found in bacteria; Region: CE4_PelA_like_C; cd10922 1162668002096 putative active site [active] 1162668002097 HsdM N-terminal domain; Region: HsdM_N; pfam12161 1162668002098 DAK2 domain; Region: Dak2; cl03685 1162668002099 Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310 1162668002100 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1162668002101 EamA-like transporter family; Region: EamA; pfam00892 1162668002102 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1162668002103 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1162668002104 putative DNA binding site [nucleotide binding]; other site 1162668002105 putative Zn2+ binding site [ion binding]; other site 1162668002106 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1162668002107 dimerization interface [polypeptide binding]; other site 1162668002108 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1162668002109 dimer interface [polypeptide binding]; other site 1162668002110 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1162668002111 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1162668002112 dimer interface [polypeptide binding]; other site 1162668002113 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1162668002114 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1162668002115 Rhodopirellula transposase DDE domain; Region: DDE_Tnp_ISAZ013; pfam07592 1162668002116 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 1162668002117 ORF6N domain; Region: ORF6N; pfam10543 1162668002118 Protein of unknown function (DUF2283); Region: DUF2283; pfam10049 1162668002119 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1162668002120 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1162668002121 active site 1162668002122 DNA binding site [nucleotide binding] 1162668002123 Int/Topo IB signature motif; other site 1162668002124 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1162668002125 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1162668002126 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 1162668002127 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1162668002128 substrate binding site [chemical binding]; other site 1162668002129 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1162668002130 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1162668002131 substrate binding site [chemical binding]; other site 1162668002132 ligand binding site [chemical binding]; other site 1162668002133 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 1162668002134 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1162668002135 NAD binding site [chemical binding]; other site 1162668002136 substrate binding site [chemical binding]; other site 1162668002137 homodimer interface [polypeptide binding]; other site 1162668002138 active site 1162668002139 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 1162668002140 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 1162668002141 substrate binding site; other site 1162668002142 tetramer interface; other site 1162668002143 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 1162668002144 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1162668002145 sequence-specific DNA binding site [nucleotide binding]; other site 1162668002146 salt bridge; other site 1162668002147 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1162668002148 non-specific DNA binding site [nucleotide binding]; other site 1162668002149 salt bridge; other site 1162668002150 sequence-specific DNA binding site [nucleotide binding]; other site 1162668002151 PAS domain S-box; Region: sensory_box; TIGR00229 1162668002152 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1162668002153 putative active site [active] 1162668002154 heme pocket [chemical binding]; other site 1162668002155 GAF domain; Region: GAF; pfam01590 1162668002156 GAF domain; Region: GAF_2; pfam13185 1162668002157 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1162668002158 PAS domain; Region: PAS_9; pfam13426 1162668002159 putative active site [active] 1162668002160 heme pocket [chemical binding]; other site 1162668002161 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1162668002162 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1162668002163 metal binding site [ion binding]; metal-binding site 1162668002164 active site 1162668002165 I-site; other site 1162668002166 potential protein location (hypothetical protein LFE_0810 [Leptospirillum ferrooxidans C2-3]) that overlaps RNA (tRNA-L) 1162668002167 Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066 1162668002168 GSH binding site [chemical binding]; other site 1162668002169 catalytic residues [active] 1162668002170 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271 1162668002171 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1162668002172 putative NAD(P) binding site [chemical binding]; other site 1162668002173 active site 1162668002174 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1162668002175 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1162668002176 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1162668002177 catalytic residue [active] 1162668002178 Protein of unknown function (DUF3501); Region: DUF3501; pfam12007 1162668002179 CoA binding domain; Region: CoA_binding; cl17356 1162668002180 arsenical pump membrane protein; Provisional; Region: PRK15445 1162668002181 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 1162668002182 transmembrane helices; other site 1162668002183 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 1162668002184 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1162668002185 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1162668002186 homodimer interface [polypeptide binding]; other site 1162668002187 catalytic residue [active] 1162668002188 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 1162668002189 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1162668002190 catalytic triad [active] 1162668002191 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 1162668002192 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1162668002193 Cl- selectivity filter; other site 1162668002194 Cl- binding residues [ion binding]; other site 1162668002195 pore gating glutamate residue; other site 1162668002196 dimer interface [polypeptide binding]; other site 1162668002197 FOG: CBS domain [General function prediction only]; Region: COG0517 1162668002198 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc; cd04612 1162668002199 EamA-like transporter family; Region: EamA; cl17759 1162668002200 di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039 1162668002201 peroxidase; Provisional; Region: PRK15000 1162668002202 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1162668002203 dimer interface [polypeptide binding]; other site 1162668002204 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1162668002205 catalytic triad [active] 1162668002206 peroxidatic and resolving cysteines [active] 1162668002207 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791 1162668002208 Cupin domain; Region: Cupin_2; pfam07883 1162668002209 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Reviewed; Region: mtnW; PRK09549 1162668002210 Ribulose bisphosphate carboxylase large chain; Region: RuBisCO_large; cl08232 1162668002211 dimer interface [polypeptide binding]; other site 1162668002212 catalytic residue [active] 1162668002213 metal binding site [ion binding]; metal-binding site 1162668002214 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1162668002215 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1162668002216 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 1162668002217 intersubunit interface [polypeptide binding]; other site 1162668002218 active site 1162668002219 Zn2+ binding site [ion binding]; other site 1162668002220 protoporphyrinogen oxidase; Region: PLN02576 1162668002221 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1162668002222 bis(5'-nucleosyl)-tetraphosphatase PrpE; Provisional; Region: PRK13625 1162668002223 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1162668002224 active site 1162668002225 metal binding site [ion binding]; metal-binding site 1162668002226 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR6; cd08272 1162668002227 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1162668002228 putative NAD(P) binding site [chemical binding]; other site 1162668002229 hopanoid biosynthesis associated radical SAM protein HpnH; Region: HpnH; TIGR03470 1162668002230 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1162668002231 FeS/SAM binding site; other site 1162668002232 Domain of unknown function (DUF3463); Region: DUF3463; pfam11946 1162668002233 Glucokinase; Region: Glucokinase; pfam02685 1162668002234 glucokinase, proteobacterial type; Region: glk; TIGR00749 1162668002235 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1162668002236 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 1162668002237 putative active site [active] 1162668002238 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 1162668002239 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1162668002240 TPP-binding site [chemical binding]; other site 1162668002241 dimer interface [polypeptide binding]; other site 1162668002242 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1162668002243 PYR/PP interface [polypeptide binding]; other site 1162668002244 dimer interface [polypeptide binding]; other site 1162668002245 TPP binding site [chemical binding]; other site 1162668002246 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1162668002247 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1162668002248 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1162668002249 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1162668002250 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 1162668002251 Bacterial trigger factor protein (TF); Region: Trigger_N; pfam05697 1162668002252 Clp protease; Region: CLP_protease; pfam00574 1162668002253 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1162668002254 oligomer interface [polypeptide binding]; other site 1162668002255 active site residues [active] 1162668002256 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 1162668002257 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1162668002258 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1162668002259 Walker A motif; other site 1162668002260 ATP binding site [chemical binding]; other site 1162668002261 Walker B motif; other site 1162668002262 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1162668002263 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 1162668002264 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 1162668002265 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1162668002266 putative FeS-containing Cyanobacterial-specific oxidoreductase; Region: cyano_FeS_chp; TIGR03279 1162668002267 Protein of unknown function (DUF512); Region: DUF512; pfam04459 1162668002268 4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate synthase [Lipid metabolism]; Region: IspE; COG1947 1162668002269 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1162668002270 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 1162668002271 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1162668002272 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1162668002273 active site 1162668002274 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 1162668002275 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1162668002276 5S rRNA interface [nucleotide binding]; other site 1162668002277 CTC domain interface [polypeptide binding]; other site 1162668002278 L16 interface [polypeptide binding]; other site 1162668002279 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1162668002280 putative active site [active] 1162668002281 catalytic residue [active] 1162668002282 GTP-binding protein YchF; Reviewed; Region: PRK09601 1162668002283 YchF GTPase; Region: YchF; cd01900 1162668002284 G1 box; other site 1162668002285 GTP/Mg2+ binding site [chemical binding]; other site 1162668002286 Switch I region; other site 1162668002287 G2 box; other site 1162668002288 Switch II region; other site 1162668002289 G3 box; other site 1162668002290 G4 box; other site 1162668002291 G5 box; other site 1162668002292 The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information...; Region: TGS; cl15768 1162668002293 Ribosomal protein S6; Region: Ribosomal_S6; pfam01250 1162668002294 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1162668002295 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1162668002296 dimer interface [polypeptide binding]; other site 1162668002297 ssDNA binding site [nucleotide binding]; other site 1162668002298 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1162668002299 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 1162668002300 Predicted membrane protein (DUF2232); Region: DUF2232; cl01728 1162668002301 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 1162668002302 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 1162668002303 Sporulation related domain; Region: SPOR; pfam05036 1162668002304 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 1162668002305 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1162668002306 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1162668002307 FeS/SAM binding site; other site 1162668002308 TRAM domain; Region: TRAM; pfam01938 1162668002309 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 1162668002310 Protein of unknown function (DUF1641); Region: DUF1641; pfam07849 1162668002311 elongation factor Tu; Reviewed; Region: PRK00049 1162668002312 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1162668002313 G1 box; other site 1162668002314 GEF interaction site [polypeptide binding]; other site 1162668002315 GTP/Mg2+ binding site [chemical binding]; other site 1162668002316 Switch I region; other site 1162668002317 G2 box; other site 1162668002318 G3 box; other site 1162668002319 Switch II region; other site 1162668002320 G4 box; other site 1162668002321 G5 box; other site 1162668002322 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1162668002323 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1162668002324 Antibiotic Binding Site [chemical binding]; other site 1162668002325 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584 1162668002326 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1162668002327 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1162668002328 putative homodimer interface [polypeptide binding]; other site 1162668002329 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1162668002330 heterodimer interface [polypeptide binding]; other site 1162668002331 homodimer interface [polypeptide binding]; other site 1162668002332 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1162668002333 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1162668002334 23S rRNA interface [nucleotide binding]; other site 1162668002335 L7/L12 interface [polypeptide binding]; other site 1162668002336 putative thiostrepton binding site; other site 1162668002337 L25 interface [polypeptide binding]; other site 1162668002338 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1162668002339 mRNA/rRNA interface [nucleotide binding]; other site 1162668002340 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1162668002341 23S rRNA interface [nucleotide binding]; other site 1162668002342 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1162668002343 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1162668002344 core dimer interface [polypeptide binding]; other site 1162668002345 peripheral dimer interface [polypeptide binding]; other site 1162668002346 L10 interface [polypeptide binding]; other site 1162668002347 L11 interface [polypeptide binding]; other site 1162668002348 putative EF-Tu interaction site [polypeptide binding]; other site 1162668002349 putative EF-G interaction site [polypeptide binding]; other site 1162668002350 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1162668002351 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1162668002352 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1162668002353 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1162668002354 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 1162668002355 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1162668002356 RPB3 interaction site [polypeptide binding]; other site 1162668002357 RPB1 interaction site [polypeptide binding]; other site 1162668002358 RPB11 interaction site [polypeptide binding]; other site 1162668002359 RPB10 interaction site [polypeptide binding]; other site 1162668002360 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1162668002361 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 1162668002362 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1162668002363 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1162668002364 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1162668002365 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 1162668002366 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 1162668002367 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 1162668002368 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 1162668002369 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1162668002370 DNA binding site [nucleotide binding] 1162668002371 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1162668002372 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1162668002373 S17 interaction site [polypeptide binding]; other site 1162668002374 S8 interaction site; other site 1162668002375 16S rRNA interaction site [nucleotide binding]; other site 1162668002376 streptomycin interaction site [chemical binding]; other site 1162668002377 23S rRNA interaction site [nucleotide binding]; other site 1162668002378 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1162668002379 30S ribosomal protein S7; Validated; Region: PRK05302 1162668002380 elongation factor G; Reviewed; Region: PRK00007 1162668002381 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1162668002382 G1 box; other site 1162668002383 putative GEF interaction site [polypeptide binding]; other site 1162668002384 GTP/Mg2+ binding site [chemical binding]; other site 1162668002385 Switch I region; other site 1162668002386 G2 box; other site 1162668002387 G3 box; other site 1162668002388 Switch II region; other site 1162668002389 G4 box; other site 1162668002390 G5 box; other site 1162668002391 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1162668002392 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1162668002393 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1162668002394 elongation factor Tu; Reviewed; Region: PRK00049 1162668002395 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1162668002396 G1 box; other site 1162668002397 GEF interaction site [polypeptide binding]; other site 1162668002398 GTP/Mg2+ binding site [chemical binding]; other site 1162668002399 Switch I region; other site 1162668002400 G2 box; other site 1162668002401 G3 box; other site 1162668002402 Switch II region; other site 1162668002403 G4 box; other site 1162668002404 G5 box; other site 1162668002405 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1162668002406 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1162668002407 Antibiotic Binding Site [chemical binding]; other site 1162668002408 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1162668002409 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 1162668002410 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 1162668002411 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1162668002412 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1162668002413 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1162668002414 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1162668002415 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1162668002416 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1162668002417 putative translocon binding site; other site 1162668002418 protein-rRNA interface [nucleotide binding]; other site 1162668002419 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1162668002420 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1162668002421 G-X-X-G motif; other site 1162668002422 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1162668002423 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1162668002424 23S rRNA interface [nucleotide binding]; other site 1162668002425 5S rRNA interface [nucleotide binding]; other site 1162668002426 putative antibiotic binding site [chemical binding]; other site 1162668002427 L25 interface [polypeptide binding]; other site 1162668002428 L27 interface [polypeptide binding]; other site 1162668002429 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1162668002430 putative translocon interaction site; other site 1162668002431 23S rRNA interface [nucleotide binding]; other site 1162668002432 signal recognition particle (SRP54) interaction site; other site 1162668002433 L23 interface [polypeptide binding]; other site 1162668002434 trigger factor interaction site; other site 1162668002435 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1162668002436 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1162668002437 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1162668002438 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1162668002439 RNA binding site [nucleotide binding]; other site 1162668002440 Protein of unknown function (DUF2614); Region: DUF2614; cl07936 1162668002441 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1162668002442 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1162668002443 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1162668002444 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1162668002445 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1162668002446 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1162668002447 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1162668002448 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1162668002449 5S rRNA interface [nucleotide binding]; other site 1162668002450 L27 interface [polypeptide binding]; other site 1162668002451 23S rRNA interface [nucleotide binding]; other site 1162668002452 L5 interface [polypeptide binding]; other site 1162668002453 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1162668002454 ribosomal protein S5, bacterial/organelle type; Region: rpsE_bact; TIGR01021 1162668002455 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1162668002456 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1162668002457 23S rRNA binding site [nucleotide binding]; other site 1162668002458 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1162668002459 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1162668002460 SecY translocase; Region: SecY; pfam00344 1162668002461 adenylate kinase; Reviewed; Region: adk; PRK00279 1162668002462 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1162668002463 AMP-binding site [chemical binding]; other site 1162668002464 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1162668002465 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1162668002466 active site 1162668002467 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1162668002468 rRNA binding site [nucleotide binding]; other site 1162668002469 predicted 30S ribosome binding site; other site 1162668002470 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 1162668002471 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1162668002472 30S ribosomal protein S11; Validated; Region: PRK05309 1162668002473 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1162668002474 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1162668002475 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1162668002476 RNA binding surface [nucleotide binding]; other site 1162668002477 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1162668002478 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1162668002479 alphaNTD homodimer interface [polypeptide binding]; other site 1162668002480 alphaNTD - beta interaction site [polypeptide binding]; other site 1162668002481 alphaNTD - beta' interaction site [polypeptide binding]; other site 1162668002482 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1162668002483 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1162668002484 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 1162668002485 dimer interface [polypeptide binding]; other site 1162668002486 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 1162668002487 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 1162668002488 NADP binding site [chemical binding]; other site 1162668002489 active site 1162668002490 putative substrate binding site [chemical binding]; other site 1162668002491 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 1162668002492 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 1162668002493 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 1162668002494 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 1162668002495 active site 1162668002496 homotetramer interface [polypeptide binding]; other site 1162668002497 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1162668002498 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 1162668002499 putative ADP-binding pocket [chemical binding]; other site 1162668002500 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1162668002501 H+ Antiporter protein; Region: 2A0121; TIGR00900 1162668002502 putative substrate translocation pore; other site 1162668002503 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1162668002504 ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197 1162668002505 NAD(P) binding site [chemical binding]; other site 1162668002506 active site 1162668002507 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1162668002508 TPR motif; other site 1162668002509 binding surface 1162668002510 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1162668002511 amidophosphoribosyltransferase; Provisional; Region: PRK09123 1162668002512 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1162668002513 active site 1162668002514 tetramer interface [polypeptide binding]; other site 1162668002515 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1162668002516 active site 1162668002517 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 1162668002518 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1162668002519 dimerization interface [polypeptide binding]; other site 1162668002520 ATP binding site [chemical binding]; other site 1162668002521 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 1162668002522 dimerization interface [polypeptide binding]; other site 1162668002523 ATP binding site [chemical binding]; other site 1162668002524 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 1162668002525 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1162668002526 putative active site [active] 1162668002527 catalytic triad [active] 1162668002528 Domain of unknown function (DUF3391); Region: DUF3391; pfam11871 1162668002529 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1162668002530 Zn2+ binding site [ion binding]; other site 1162668002531 Mg2+ binding site [ion binding]; other site 1162668002532 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1162668002533 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1162668002534 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 1162668002535 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1162668002536 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1162668002537 HlyD family secretion protein; Region: HlyD_3; pfam13437 1162668002538 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1162668002539 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1162668002540 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1162668002541 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1162668002542 dimerization interface [polypeptide binding]; other site 1162668002543 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 1162668002544 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1162668002545 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1162668002546 Walker A/P-loop; other site 1162668002547 ATP binding site [chemical binding]; other site 1162668002548 Q-loop/lid; other site 1162668002549 ABC transporter signature motif; other site 1162668002550 Walker B; other site 1162668002551 D-loop; other site 1162668002552 H-loop/switch region; other site 1162668002553 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1162668002554 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1162668002555 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 1162668002556 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1162668002557 FAD binding pocket [chemical binding]; other site 1162668002558 conserved FAD binding motif [chemical binding]; other site 1162668002559 phosphate binding motif [ion binding]; other site 1162668002560 beta-alpha-beta structure motif; other site 1162668002561 NAD binding pocket [chemical binding]; other site 1162668002562 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1162668002563 Domain of unknown function (DUF1848); Region: DUF1848; pfam08902 1162668002564 Integrase core domain; Region: rve; pfam00665 1162668002565 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 1162668002566 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 1162668002567 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 1162668002568 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 1162668002569 NAD binding site [chemical binding]; other site 1162668002570 homodimer interface [polypeptide binding]; other site 1162668002571 active site 1162668002572 substrate binding site [chemical binding]; other site 1162668002573 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1162668002574 binding surface 1162668002575 TPR motif; other site 1162668002576 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1162668002577 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1162668002578 binding surface 1162668002579 TPR motif; other site 1162668002580 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1162668002581 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1162668002582 binding surface 1162668002583 TPR motif; other site 1162668002584 TPR repeat; Region: TPR_11; pfam13414 1162668002585 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1162668002586 binding surface 1162668002587 TPR motif; other site 1162668002588 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1162668002589 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1162668002590 inhibitor-cofactor binding pocket; inhibition site 1162668002591 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1162668002592 catalytic residue [active] 1162668002593 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1162668002594 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 1162668002595 putative ligand binding site [chemical binding]; other site 1162668002596 putative NAD binding site [chemical binding]; other site 1162668002597 catalytic site [active] 1162668002598 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1162668002599 tyrosine decarboxylase MnfA; Region: tyr_de_CO2_Arch; TIGR03812 1162668002600 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1162668002601 catalytic residue [active] 1162668002602 voltage-gated potassium channel; Provisional; Region: PRK10537 1162668002603 Ion channel; Region: Ion_trans_2; pfam07885 1162668002604 TrkA-N domain; Region: TrkA_N; pfam02254 1162668002605 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1162668002606 Protein of unknown function (DUF3105); Region: DUF3105; pfam11303 1162668002607 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1162668002608 active site 1162668002609 thiamine phosphate binding site [chemical binding]; other site 1162668002610 pyrophosphate binding site [ion binding]; other site 1162668002611 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1162668002612 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1162668002613 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1162668002614 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1162668002615 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1162668002616 carboxyltransferase (CT) interaction site; other site 1162668002617 biotinylation site [posttranslational modification]; other site 1162668002618 elongation factor P; Validated; Region: PRK00529 1162668002619 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1162668002620 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1162668002621 RNA binding site [nucleotide binding]; other site 1162668002622 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1162668002623 RNA binding site [nucleotide binding]; other site 1162668002624 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 1162668002625 Dehydroquinase class II; Region: DHquinase_II; pfam01220 1162668002626 trimer interface [polypeptide binding]; other site 1162668002627 active site 1162668002628 dimer interface [polypeptide binding]; other site 1162668002629 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1162668002630 binding surface 1162668002631 TPR motif; other site 1162668002632 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 1162668002633 Flavoprotein; Region: Flavoprotein; pfam02441 1162668002634 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 1162668002635 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 1162668002636 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1162668002637 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1162668002638 catalytic site [active] 1162668002639 G-X2-G-X-G-K; other site 1162668002640 Domain of unknown function (DUF370); Region: DUF370; cl00898 1162668002641 hypothetical protein; Provisional; Region: PRK11820 1162668002642 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 1162668002643 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 1162668002644 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 1162668002645 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 1162668002646 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1162668002647 FOG: CBS domain [General function prediction only]; Region: COG0517 1162668002648 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800 1162668002649 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1162668002650 binding surface 1162668002651 TPR motif; other site 1162668002652 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1162668002653 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 1162668002654 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 1162668002655 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1162668002656 catalytic residue [active] 1162668002657 6-carboxyhexanoate--CoA ligase; Region: BioW; cl00625 1162668002658 biotin synthase; Region: bioB; TIGR00433 1162668002659 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1162668002660 FeS/SAM binding site; other site 1162668002661 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 1162668002662 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1162668002663 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 1162668002664 FMN binding site [chemical binding]; other site 1162668002665 active site 1162668002666 substrate binding site [chemical binding]; other site 1162668002667 catalytic residue [active] 1162668002668 Rrf2 family protein; Region: rrf2_super; TIGR00738 1162668002669 Transcriptional regulator; Region: Rrf2; pfam02082 1162668002670 glycyl-tRNA synthetase subunit alpha; Validated; Region: glyQ; PRK09348 1162668002671 motif 1; other site 1162668002672 dimer interface [polypeptide binding]; other site 1162668002673 active site 1162668002674 motif 2; other site 1162668002675 motif 3; other site 1162668002676 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 1162668002677 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1162668002678 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 1162668002679 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 1162668002680 catalytic motif [active] 1162668002681 Zn binding site [ion binding]; other site 1162668002682 RibD C-terminal domain; Region: RibD_C; cl17279 1162668002683 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 1162668002684 Lumazine binding domain; Region: Lum_binding; pfam00677 1162668002685 Lumazine binding domain; Region: Lum_binding; pfam00677 1162668002686 PBP superfamily domain; Region: PBP_like_2; cl17296 1162668002687 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1162668002688 GAF domain; Region: GAF; pfam01590 1162668002689 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1162668002690 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1162668002691 metal binding site [ion binding]; metal-binding site 1162668002692 active site 1162668002693 I-site; other site 1162668002694 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 1162668002695 active site 1162668002696 SAM binding site [chemical binding]; other site 1162668002697 homodimer interface [polypeptide binding]; other site 1162668002698 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 1162668002699 active site 1162668002700 SAM binding site [chemical binding]; other site 1162668002701 homodimer interface [polypeptide binding]; other site 1162668002702 cobyric acid synthase; Provisional; Region: PRK00784 1162668002703 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1162668002704 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1162668002705 catalytic triad [active] 1162668002706 CobD/Cbib protein; Region: CobD_Cbib; pfam03186 1162668002707 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 1162668002708 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1162668002709 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1162668002710 homodimer interface [polypeptide binding]; other site 1162668002711 catalytic residue [active] 1162668002712 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 1162668002713 DNA binding residues [nucleotide binding] 1162668002714 fumarate hydratase; Reviewed; Region: fumC; PRK00485 1162668002715 Class II fumarases; Region: Fumarase_classII; cd01362 1162668002716 active site 1162668002717 tetramer interface [polypeptide binding]; other site 1162668002718 Acylphosphatase; Region: Acylphosphatase; pfam00708 1162668002719 RNA polymerase sigma factor RpoS; Region: rpoS_proteo; TIGR02394 1162668002720 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1162668002721 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1162668002722 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1162668002723 DNA binding residues [nucleotide binding] 1162668002724 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1162668002725 active site 1162668002726 YCII-related domain; Region: YCII; cl00999 1162668002727 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 1162668002728 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 1162668002729 active site 1162668002730 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 1162668002731 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1162668002732 active site 1162668002733 FMN binding site [chemical binding]; other site 1162668002734 substrate binding site [chemical binding]; other site 1162668002735 3Fe-4S cluster binding site [ion binding]; other site 1162668002736 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cd00504 1162668002737 domain_subunit interface; other site 1162668002738 Predicted HD-superfamily hydrolase [General function prediction only]; Region: COG3481 1162668002739 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1162668002740 FAD binding domain; Region: FAD_binding_4; pfam01565 1162668002741 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1162668002742 Cysteine-rich domain; Region: CCG; pfam02754 1162668002743 Cysteine-rich domain; Region: CCG; pfam02754 1162668002744 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1162668002745 substrate binding site [chemical binding]; other site 1162668002746 Transposase IS200 like; Region: Y1_Tnp; pfam01797 1162668002747 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1162668002748 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1162668002749 Probable transposase; Region: OrfB_IS605; pfam01385 1162668002750 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1162668002751 DinB family; Region: DinB; cl17821 1162668002752 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1162668002753 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1162668002754 Membrane bound YbgT-like protein; Region: YbgT_YccB; pfam08173 1162668002755 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1162668002756 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1162668002757 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 1162668002758 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 1162668002759 PAS fold; Region: PAS_4; pfam08448 1162668002760 phage shock protein operon transcriptional activator; Provisional; Region: pspF; PRK11608 1162668002761 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1162668002762 Walker A motif; other site 1162668002763 ATP binding site [chemical binding]; other site 1162668002764 Walker B motif; other site 1162668002765 arginine finger; other site 1162668002766 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1162668002767 CheB methylesterase; Region: CheB_methylest; pfam01339 1162668002768 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 1162668002769 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 1162668002770 TPR/MLP1/MLP2-like protein; Region: TPR_MLP1_2; pfam07926 1162668002771 TATA element modulatory factor 1 TATA binding; Region: TMF_TATA_bd; pfam12325 1162668002772 PAS domain; Region: PAS_10; pfam13596 1162668002773 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1162668002774 PAS domain; Region: PAS_9; pfam13426 1162668002775 putative active site [active] 1162668002776 heme pocket [chemical binding]; other site 1162668002777 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1162668002778 PAS domain; Region: PAS_9; pfam13426 1162668002779 putative active site [active] 1162668002780 heme pocket [chemical binding]; other site 1162668002781 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1162668002782 metal binding site [ion binding]; metal-binding site 1162668002783 active site 1162668002784 I-site; other site 1162668002785 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1162668002786 Protein of unknown function (DUF2844); Region: DUF2844; pfam11005 1162668002787 Protein of unknown function (DUF3443); Region: DUF3443; pfam11925 1162668002788 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 1162668002789 putative catalytic site [active] 1162668002790 putative phosphate binding site [ion binding]; other site 1162668002791 active site 1162668002792 metal binding site A [ion binding]; metal-binding site 1162668002793 DNA binding site [nucleotide binding] 1162668002794 putative AP binding site [nucleotide binding]; other site 1162668002795 putative metal binding site B [ion binding]; other site 1162668002796 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl15777 1162668002797 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 1162668002798 active site 1162668002799 oligomerization interface [polypeptide binding]; other site 1162668002800 metal binding site [ion binding]; metal-binding site 1162668002801 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 1162668002802 FAD binding site [chemical binding]; other site 1162668002803 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190 1162668002804 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1162668002805 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1162668002806 homodimer interface [polypeptide binding]; other site 1162668002807 NADP binding site [chemical binding]; other site 1162668002808 substrate binding site [chemical binding]; other site 1162668002809 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 1162668002810 A new structural DNA glycosylase; Region: AlkD_like; cd06561 1162668002811 active site 1162668002812 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 1162668002813 GTP cyclohydrolase I; Provisional; Region: PLN03044 1162668002814 active site 1162668002815 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 1162668002816 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360 1162668002817 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1162668002818 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1162668002819 transmembrane helices; other site 1162668002820 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1162668002821 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1162668002822 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1162668002823 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1162668002824 putative acyl-acceptor binding pocket; other site 1162668002825 cytidylate kinase; Provisional; Region: cmk; PRK00023 1162668002826 AAA domain; Region: AAA_17; pfam13207 1162668002827 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1162668002828 CMP-binding site; other site 1162668002829 The sites determining sugar specificity; other site 1162668002830 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 1162668002831 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1162668002832 hinge; other site 1162668002833 active site 1162668002834 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 1162668002835 prephenate dehydrogenase; Validated; Region: PRK08507 1162668002836 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 1162668002837 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 1162668002838 Chorismate mutase type II; Region: CM_2; smart00830 1162668002839 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 1162668002840 Prephenate dehydratase; Region: PDT; pfam00800 1162668002841 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1162668002842 putative L-Phe binding site [chemical binding]; other site 1162668002843 hypothetical protein; Validated; Region: PRK00110 1162668002844 Fusaric acid resistance protein family; Region: FUSC; pfam04632 1162668002845 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1162668002846 Protein of unknown function (DUF1656); Region: DUF1656; pfam07869 1162668002847 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 1162668002848 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1162668002849 HlyD family secretion protein; Region: HlyD_3; pfam13437 1162668002850 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 1162668002851 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 1162668002852 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 1162668002853 catalytic site [active] 1162668002854 active site 1162668002855 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1162668002856 maltooligosyl trehalose synthase; Provisional; Region: PRK14511 1162668002857 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1162668002858 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 1162668002859 active site 1162668002860 catalytic site [active] 1162668002861 trehalose synthase; Region: treS_nterm; TIGR02456 1162668002862 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1162668002863 active site 1162668002864 catalytic site [active] 1162668002865 trehalose synthase; Region: treS_nterm; TIGR02456 1162668002866 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 1162668002867 active site 1162668002868 catalytic site [active] 1162668002869 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 1162668002870 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 1162668002871 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1162668002872 active site 1162668002873 homodimer interface [polypeptide binding]; other site 1162668002874 catalytic site [active] 1162668002875 acceptor binding site [chemical binding]; other site 1162668002876 trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457 1162668002877 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 1162668002878 Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; cl01130 1162668002879 Predicted membrane protein [Function unknown]; Region: COG3174 1162668002880 Domain of unknown function (DUF4010); Region: DUF4010; pfam13194 1162668002881 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1162668002882 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 1162668002883 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1162668002884 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1162668002885 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1162668002886 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 1162668002887 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 1162668002888 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1162668002889 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 1162668002890 NAD binding site [chemical binding]; other site 1162668002891 putative substrate binding site 2 [chemical binding]; other site 1162668002892 putative substrate binding site 1 [chemical binding]; other site 1162668002893 active site 1162668002894 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 1162668002895 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 1162668002896 active site 1162668002897 multimer interface [polypeptide binding]; other site 1162668002898 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1162668002899 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1162668002900 active site 1162668002901 HIGH motif; other site 1162668002902 dimer interface [polypeptide binding]; other site 1162668002903 KMSKS motif; other site 1162668002904 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1162668002905 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 1162668002906 HlyD family secretion protein; Region: HlyD_3; pfam13437 1162668002907 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 1162668002908 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 1162668002909 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 1162668002910 catalytic triad [active] 1162668002911 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1162668002912 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 1162668002913 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 1162668002914 dimer interface [polypeptide binding]; other site 1162668002915 [2Fe-2S] cluster binding site [ion binding]; other site 1162668002916 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 1162668002917 SLBB domain; Region: SLBB; pfam10531 1162668002918 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 1162668002919 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 1162668002920 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1162668002921 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1162668002922 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 1162668002923 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 1162668002924 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1162668002925 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1162668002926 dimer interface [polypeptide binding]; other site 1162668002927 putative CheW interface [polypeptide binding]; other site 1162668002928 Predicted transcriptional regulator [Transcription]; Region: COG1959 1162668002929 Transcriptional regulator; Region: Rrf2; pfam02082 1162668002930 Predicted membrane protein (DUF2231); Region: DUF2231; cl01730 1162668002931 Uncharacterized conserved protein [Function unknown]; Region: COG4095 1162668002932 Hydroxyneurosporene synthase (CrtC); Region: CrtC; pfam07143 1162668002933 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1162668002934 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 1162668002935 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1162668002936 FtsX-like permease family; Region: FtsX; pfam02687 1162668002937 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1162668002938 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1162668002939 Walker A/P-loop; other site 1162668002940 ATP binding site [chemical binding]; other site 1162668002941 Q-loop/lid; other site 1162668002942 ABC transporter signature motif; other site 1162668002943 Walker B; other site 1162668002944 D-loop; other site 1162668002945 H-loop/switch region; other site 1162668002946 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1162668002947 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1162668002948 AAA-like domain; Region: AAA_10; pfam12846 1162668002949 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 1162668002950 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cl11423 1162668002951 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1162668002952 Walker A motif; other site 1162668002953 ATP binding site [chemical binding]; other site 1162668002954 Walker B motif; other site 1162668002955 arginine finger; other site 1162668002956 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 1162668002957 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 1162668002958 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1162668002959 TPR motif; other site 1162668002960 binding surface 1162668002961 SEC-C motif; Region: SEC-C; pfam02810 1162668002962 coproporphyrinogen III oxidase; Validated; Region: PRK05628 1162668002963 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 1162668002964 FeS/SAM binding site; other site 1162668002965 HemN C-terminal domain; Region: HemN_C; pfam06969 1162668002966 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1162668002967 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 1162668002968 active site 1162668002969 DNA binding site [nucleotide binding] 1162668002970 Int/Topo IB signature motif; other site 1162668002971 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 1162668002972 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1162668002973 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1162668002974 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 1162668002975 dinuclear metal binding motif [ion binding]; other site 1162668002976 glycogen synthase; Provisional; Region: glgA; PRK00654 1162668002977 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 1162668002978 ADP-binding pocket [chemical binding]; other site 1162668002979 homodimer interface [polypeptide binding]; other site 1162668002980 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1162668002981 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1162668002982 ligand binding site [chemical binding]; other site 1162668002983 flexible hinge region; other site 1162668002984 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1162668002985 putative switch regulator; other site 1162668002986 non-specific DNA interactions [nucleotide binding]; other site 1162668002987 DNA binding site [nucleotide binding] 1162668002988 sequence specific DNA binding site [nucleotide binding]; other site 1162668002989 putative cAMP binding site [chemical binding]; other site 1162668002990 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1162668002991 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1162668002992 dimer interface [polypeptide binding]; other site 1162668002993 putative CheW interface [polypeptide binding]; other site 1162668002994 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1162668002995 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1162668002996 catalytic residue [active] 1162668002997 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1162668002998 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1162668002999 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 1162668003000 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1162668003001 TPR motif; other site 1162668003002 binding surface 1162668003003 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 1162668003004 dimer interface [polypeptide binding]; other site 1162668003005 [2Fe-2S] cluster binding site [ion binding]; other site 1162668003006 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 1162668003007 SLBB domain; Region: SLBB; pfam10531 1162668003008 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 1162668003009 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 1162668003010 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1162668003011 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 1162668003012 ATP-grasp domain; Region: ATP-grasp; pfam02222 1162668003013 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 1162668003014 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1162668003015 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1162668003016 dimerization interface [polypeptide binding]; other site 1162668003017 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 1162668003018 cyclase homology domain; Region: CHD; cd07302 1162668003019 nucleotidyl binding site; other site 1162668003020 metal binding site [ion binding]; metal-binding site 1162668003021 dimer interface [polypeptide binding]; other site 1162668003022 NHL repeat; Region: NHL; pfam01436 1162668003023 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 1162668003024 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 1162668003025 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218 1162668003026 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1162668003027 MarR family; Region: MarR; pfam01047 1162668003028 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 1162668003029 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1162668003030 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1162668003031 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1162668003032 HlyD family secretion protein; Region: HlyD_3; pfam13437 1162668003033 aminotransferase; Validated; Region: PRK08175 1162668003034 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1162668003035 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1162668003036 homodimer interface [polypeptide binding]; other site 1162668003037 catalytic residue [active] 1162668003038 homoserine dehydrogenase; Provisional; Region: PRK06349 1162668003039 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1162668003040 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1162668003041 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 1162668003042 threonine synthase; Reviewed; Region: PRK06721 1162668003043 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 1162668003044 homodimer interface [polypeptide binding]; other site 1162668003045 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1162668003046 catalytic residue [active] 1162668003047 proposed homoserine kinase; Region: hyp_Hser_kinase; TIGR02535 1162668003048 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: PhosphMutase; cl17294 1162668003049 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: PhosphMutase; cl17294 1162668003050 aspartate kinase; Reviewed; Region: PRK06635 1162668003051 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 1162668003052 putative nucleotide binding site [chemical binding]; other site 1162668003053 putative catalytic residues [active] 1162668003054 putative Mg ion binding site [ion binding]; other site 1162668003055 putative aspartate binding site [chemical binding]; other site 1162668003056 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 1162668003057 putative allosteric regulatory site; other site 1162668003058 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 1162668003059 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 1162668003060 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 1162668003061 active site 1162668003062 catalytic residues [active] 1162668003063 metal binding site [ion binding]; metal-binding site 1162668003064 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 1162668003065 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 1162668003066 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 1162668003067 active site 1162668003068 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1162668003069 IHF - DNA interface [nucleotide binding]; other site 1162668003070 IHF dimer interface [polypeptide binding]; other site 1162668003071 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1162668003072 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1162668003073 DNA binding residues [nucleotide binding] 1162668003074 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 1162668003075 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 1162668003076 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1162668003077 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1162668003078 active site 1162668003079 HIGH motif; other site 1162668003080 nucleotide binding site [chemical binding]; other site 1162668003081 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1162668003082 KMSKS motif; other site 1162668003083 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1162668003084 tRNA binding surface [nucleotide binding]; other site 1162668003085 anticodon binding site; other site 1162668003086 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1162668003087 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1162668003088 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1162668003089 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1162668003090 catalytic residues [active] 1162668003091 NAD synthetase; Provisional; Region: PRK13981 1162668003092 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 1162668003093 multimer interface [polypeptide binding]; other site 1162668003094 active site 1162668003095 catalytic triad [active] 1162668003096 protein interface 1 [polypeptide binding]; other site 1162668003097 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1162668003098 homodimer interface [polypeptide binding]; other site 1162668003099 NAD binding pocket [chemical binding]; other site 1162668003100 ATP binding pocket [chemical binding]; other site 1162668003101 Mg binding site [ion binding]; other site 1162668003102 active-site loop [active] 1162668003103 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 1162668003104 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 1162668003105 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1162668003106 dimerization interface [polypeptide binding]; other site 1162668003107 active site 1162668003108 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 1162668003109 homopentamer interface [polypeptide binding]; other site 1162668003110 active site 1162668003111 transcription antitermination factor NusB; Region: nusB; TIGR01951 1162668003112 putative RNA binding site [nucleotide binding]; other site 1162668003113 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1162668003114 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1162668003115 metal binding site [ion binding]; metal-binding site 1162668003116 active site 1162668003117 I-site; other site 1162668003118 adenylosuccinate lyase; Provisional; Region: PRK07492 1162668003119 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 1162668003120 tetramer interface [polypeptide binding]; other site 1162668003121 active site 1162668003122 Adenylosuccinate lyase C-terminus; Region: ADSL_C; pfam10397 1162668003123 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 1162668003124 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 1162668003125 ATP binding site [chemical binding]; other site 1162668003126 active site 1162668003127 substrate binding site [chemical binding]; other site 1162668003128 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700 1162668003129 Asparaginase [Amino acid transport and metabolism]; Region: COG1446 1162668003130 active site 1162668003131 dimer interface [polypeptide binding]; other site 1162668003132 catalytic nucleophile [active] 1162668003133 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 1162668003134 active site 1162668003135 NTP binding site [chemical binding]; other site 1162668003136 metal binding triad [ion binding]; metal-binding site 1162668003137 antibiotic binding site [chemical binding]; other site 1162668003138 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 1162668003139 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1162668003140 EamA-like transporter family; Region: EamA; pfam00892 1162668003141 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 1162668003142 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1162668003143 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1162668003144 hopanoid C-3 methylase HpnR; Region: HpnR_B12_rSAM; TIGR04367 1162668003145 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 1162668003146 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1162668003147 FeS/SAM binding site; other site 1162668003148 Outer membrane lipoprotein Slp family; Region: Slp; cl01164 1162668003149 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 1162668003150 homodimer interface [polypeptide binding]; other site 1162668003151 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 1162668003152 active site pocket [active] 1162668003153 3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963 1162668003154 classical (c) SDRs; Region: SDR_c; cd05233 1162668003155 NAD(P) binding site [chemical binding]; other site 1162668003156 active site 1162668003157 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1162668003158 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1162668003159 Coenzyme A binding pocket [chemical binding]; other site 1162668003160 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1162668003161 PAS domain; Region: PAS_9; pfam13426 1162668003162 putative active site [active] 1162668003163 heme pocket [chemical binding]; other site 1162668003164 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1162668003165 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 1162668003166 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1162668003167 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1162668003168 NAD(P) binding site [chemical binding]; other site 1162668003169 active site 1162668003170 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1162668003171 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 1162668003172 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 1162668003173 Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_1; cd07020 1162668003174 active site residues [active] 1162668003175 dimer interface [polypeptide binding]; other site 1162668003176 NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957 1162668003177 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 1162668003178 ModD; Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase) present in some modABC operons in bacteria, which are involved in molybdate transport. In general, QPRTases are part of the de novo synthesis pathway of NAD in both prokaryotes and...; Region: modD_like; cd01573 1162668003179 dimerization interface [polypeptide binding]; other site 1162668003180 active site 1162668003181 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 1162668003182 LL-diaminopimelate aminotransferase; Region: DapC_direct; TIGR03540 1162668003183 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 1162668003184 NADPH bind site [chemical binding]; other site 1162668003185 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 1162668003186 putative FMN binding site [chemical binding]; other site 1162668003187 NADPH bind site [chemical binding]; other site 1162668003188 Arsenate Reductase (ArsC) family, 15kD protein subfamily; composed of proteins of unknown function with similarity to thioredoxin-fold arsenic reductases, ArsC. It is encoded by an ORF present in a gene cluster associated with nitrogen fixation that also...; Region: ArsC_15kD; cd03033 1162668003189 ArsC family; Region: ArsC; pfam03960 1162668003190 putative catalytic residues [active] 1162668003191 NifZ domain; Region: NifZ; pfam04319 1162668003192 PAS fold; Region: PAS_4; pfam08448 1162668003193 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1162668003194 putative active site [active] 1162668003195 heme pocket [chemical binding]; other site 1162668003196 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1162668003197 PAS domain; Region: PAS_9; pfam13426 1162668003198 putative active site [active] 1162668003199 heme pocket [chemical binding]; other site 1162668003200 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1162668003201 GAF domain; Region: GAF; cl17456 1162668003202 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1162668003203 PAS domain; Region: PAS_9; pfam13426 1162668003204 putative active site [active] 1162668003205 heme pocket [chemical binding]; other site 1162668003206 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1162668003207 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1162668003208 metal binding site [ion binding]; metal-binding site 1162668003209 active site 1162668003210 I-site; other site 1162668003211 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1162668003212 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 1162668003213 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1162668003214 FeS/SAM binding site; other site 1162668003215 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1162668003216 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1162668003217 active site 1162668003218 phosphorylation site [posttranslational modification] 1162668003219 intermolecular recognition site; other site 1162668003220 dimerization interface [polypeptide binding]; other site 1162668003221 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1162668003222 DNA binding residues [nucleotide binding] 1162668003223 dimerization interface [polypeptide binding]; other site 1162668003224 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1162668003225 ATP binding site [chemical binding]; other site 1162668003226 Mg2+ binding site [ion binding]; other site 1162668003227 G-X-G motif; other site 1162668003228 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1162668003229 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1162668003230 Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642 1162668003231 K+-transporting ATPase, c chain [Inorganic ion transport and metabolism]; Region: KdpC; COG2156 1162668003232 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 1162668003233 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 1162668003234 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1162668003235 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1162668003236 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 1162668003237 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 1162668003238 Ligand Binding Site [chemical binding]; other site 1162668003239 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 1162668003240 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 1162668003241 Ligand Binding Site [chemical binding]; other site 1162668003242 Microscilla MS158 and related proteins, metallophosphatase domain; Region: MPP_MS158; cd07404 1162668003243 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1162668003244 putative active site [active] 1162668003245 putative metal binding site [ion binding]; other site 1162668003246 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1162668003247 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1162668003248 active site 1162668003249 metal binding site [ion binding]; metal-binding site 1162668003250 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1162668003251 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1162668003252 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 1162668003253 Peptidase family M50; Region: Peptidase_M50; pfam02163 1162668003254 active site 1162668003255 putative substrate binding region [chemical binding]; other site 1162668003256 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1162668003257 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1162668003258 active site 1162668003259 HIGH motif; other site 1162668003260 dimer interface [polypeptide binding]; other site 1162668003261 KMSKS motif; other site 1162668003262 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 1162668003263 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 1162668003264 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 1162668003265 active site 1162668003266 PHP Thumb interface [polypeptide binding]; other site 1162668003267 metal binding site [ion binding]; metal-binding site 1162668003268 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1162668003269 generic binding surface I; other site 1162668003270 generic binding surface II; other site 1162668003271 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1162668003272 Part of AAA domain; Region: AAA_19; pfam13245 1162668003273 Family description; Region: UvrD_C_2; pfam13538 1162668003274 potential protein location (hypothetical protein LFE_1196 [Leptospirillum ferrooxidans C2-3]) that overlaps RNA (5S ribosomal RNA) 1162668003275 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1162668003276 peptide binding site [polypeptide binding]; other site 1162668003277 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1162668003278 Nuclease-related domain; Region: NERD; pfam08378 1162668003279 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 1162668003280 homodimer interface [polypeptide binding]; other site 1162668003281 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1162668003282 catalytic residue [active] 1162668003283 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 1162668003284 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 1162668003285 ligand binding site [chemical binding]; other site 1162668003286 NAD binding site [chemical binding]; other site 1162668003287 dimerization interface [polypeptide binding]; other site 1162668003288 catalytic site [active] 1162668003289 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 1162668003290 putative L-serine binding site [chemical binding]; other site 1162668003291 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1162668003292 Histidyl-tRNA synthetase; Region: tRNA-synt_His; pfam13393 1162668003293 dimer interface [polypeptide binding]; other site 1162668003294 motif 1; other site 1162668003295 active site 1162668003296 motif 2; other site 1162668003297 motif 3; other site 1162668003298 replicative DNA helicase; Region: DnaB; TIGR00665 1162668003299 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1162668003300 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1162668003301 Walker A motif; other site 1162668003302 ATP binding site [chemical binding]; other site 1162668003303 Walker B motif; other site 1162668003304 DNA binding loops [nucleotide binding] 1162668003305 type II secretion system protein J; Region: gspJ; TIGR01711 1162668003306 Prokaryotic N-terminal methylation site; Region: N_methyl_3; pfam13633 1162668003307 type II secretion system protein I; Region: gspI; TIGR01707 1162668003308 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 1162668003309 Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501 1162668003310 Transposase IS200 like; Region: Y1_Tnp; pfam01797 1162668003311 Protein of unknown function (DUF1207); Region: DUF1207; pfam06727 1162668003312 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1162668003313 DNA-binding site [nucleotide binding]; DNA binding site 1162668003314 RNA-binding motif; other site 1162668003315 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1162668003316 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 1162668003317 Walker A motif; other site 1162668003318 ATP binding site [chemical binding]; other site 1162668003319 Walker B motif; other site 1162668003320 arginine finger; other site 1162668003321 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1162668003322 Protein of unknown function (DUF3105); Region: DUF3105; pfam11303 1162668003323 Permease; Region: Permease; pfam02405 1162668003324 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1162668003325 thiamine ABC transporter, ATP-binding protein; Region: thiQ; TIGR01277 1162668003326 Walker A/P-loop; other site 1162668003327 ATP binding site [chemical binding]; other site 1162668003328 Q-loop/lid; other site 1162668003329 ABC transporter signature motif; other site 1162668003330 Walker B; other site 1162668003331 D-loop; other site 1162668003332 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 1162668003333 mce related protein; Region: MCE; pfam02470 1162668003334 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1162668003335 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1162668003336 binding surface 1162668003337 TPR motif; other site 1162668003338 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1162668003339 Protein involved in formate dehydrogenase formation; Region: FdhE; pfam04216 1162668003340 RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably...; Region: RING; cl17238 1162668003341 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1162668003342 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1162668003343 Zn2+ binding site [ion binding]; other site 1162668003344 Mg2+ binding site [ion binding]; other site 1162668003345 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1162668003346 synthetase active site [active] 1162668003347 NTP binding site [chemical binding]; other site 1162668003348 metal binding site [ion binding]; metal-binding site 1162668003349 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1162668003350 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1162668003351 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 1162668003352 DHH family; Region: DHH; pfam01368 1162668003353 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 1162668003354 Protein export membrane protein; Region: SecD_SecF; cl14618 1162668003355 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 1162668003356 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 1162668003357 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 1162668003358 Preprotein translocase subunit; Region: YajC; pfam02699 1162668003359 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 1162668003360 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 1162668003361 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 1162668003362 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 1162668003363 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1162668003364 active site 1162668003365 HIGH motif; other site 1162668003366 nucleotide binding site [chemical binding]; other site 1162668003367 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1162668003368 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1162668003369 KMSK motif region; other site 1162668003370 tRNA binding surface [nucleotide binding]; other site 1162668003371 DALR anticodon binding domain; Region: DALR_1; smart00836 1162668003372 anticodon binding site; other site 1162668003373 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1162668003374 active site 1162668003375 Protein required for attachment to host cells; Region: Host_attach; pfam10116 1162668003376 UGMP family protein; Validated; Region: PRK09604 1162668003377 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1162668003378 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 1162668003379 Clp amino terminal domain; Region: Clp_N; pfam02861 1162668003380 Clp amino terminal domain; Region: Clp_N; pfam02861 1162668003381 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1162668003382 Walker A motif; other site 1162668003383 ATP binding site [chemical binding]; other site 1162668003384 Walker B motif; other site 1162668003385 arginine finger; other site 1162668003386 UvrB/uvrC motif; Region: UVR; pfam02151 1162668003387 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1162668003388 Walker A motif; other site 1162668003389 ATP binding site [chemical binding]; other site 1162668003390 Walker B motif; other site 1162668003391 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1162668003392 Uncharacterized conserved protein [Function unknown]; Region: COG2308 1162668003393 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 1162668003394 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 1162668003395 Predicted proteasome-type protease [Posttranslational modification, protein turnover, chaperones]; Region: COG3484 1162668003396 Bacterial proteasome, beta subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that...; Region: proteasome_beta_bacterial; cd03765 1162668003397 H+ Antiporter protein; Region: 2A0121; TIGR00900 1162668003398 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1162668003399 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1162668003400 putative substrate translocation pore; other site 1162668003401 Dienelactone hydrolase family; Region: DLH; pfam01738 1162668003402 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1162668003403 The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880 1162668003404 OsmC-like protein; Region: OsmC; pfam02566 1162668003405 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1162668003406 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1162668003407 metal binding site [ion binding]; metal-binding site 1162668003408 active site 1162668003409 I-site; other site 1162668003410 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1162668003411 dimerization interface [polypeptide binding]; other site 1162668003412 putative DNA binding site [nucleotide binding]; other site 1162668003413 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1162668003414 putative Zn2+ binding site [ion binding]; other site 1162668003415 tetrahydromethanopterin S-methyltransferase subunit A; Provisional; Region: PRK00964 1162668003416 Tetrahydromethanopterin S-methyltransferase, subunit A; Region: MtrA; cl04449 1162668003417 Domain of unknown function (DUF4346); Region: DUF4346; pfam14251 1162668003418 MerT mercuric transport protein; Region: MerT; cl03578 1162668003419 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1162668003420 S-adenosylmethionine binding site [chemical binding]; other site 1162668003421 potential frameshift: common BLAST hit: gi|198282333|ref|YP_002218654.1| class V aminotransferase 1162668003422 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1162668003423 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1162668003424 catalytic residue [active] 1162668003425 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1162668003426 Short C-terminal domain; Region: SHOCT; pfam09851 1162668003427 Family description; Region: DsbD_2; pfam13386 1162668003428 OsmC-like protein; Region: OsmC; pfam02566 1162668003429 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1162668003430 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1162668003431 dimerization interface [polypeptide binding]; other site 1162668003432 putative DNA binding site [nucleotide binding]; other site 1162668003433 putative Zn2+ binding site [ion binding]; other site 1162668003434 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1162668003435 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1162668003436 putative substrate translocation pore; other site 1162668003437 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 1162668003438 Predicted transcriptional regulator [Transcription]; Region: COG3636; cl17681 1162668003439 Predicted transcriptional regulator [Transcription]; Region: COG3636; cl17681 1162668003440 PEGA domain; Region: PEGA; pfam08308 1162668003441 Helix-turn-helix domain; Region: HTH_25; pfam13413 1162668003442 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1162668003443 TPR motif; other site 1162668003444 binding surface 1162668003445 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1162668003446 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1162668003447 binding surface 1162668003448 TPR motif; other site 1162668003449 TPR repeat; Region: TPR_11; pfam13414 1162668003450 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1162668003451 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1162668003452 substrate binding site [chemical binding]; other site 1162668003453 ATP binding site [chemical binding]; other site 1162668003454 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 1162668003455 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1162668003456 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1162668003457 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 1162668003458 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1162668003459 ATP binding site [chemical binding]; other site 1162668003460 Mg2+ binding site [ion binding]; other site 1162668003461 G-X-G motif; other site 1162668003462 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 1162668003463 ATP binding site [chemical binding]; other site 1162668003464 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 1162668003465 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 1162668003466 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1162668003467 binding surface 1162668003468 TPR motif; other site 1162668003469 translocation protein TolB; Provisional; Region: tolB; PRK04922 1162668003470 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1162668003471 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1162668003472 TolA protein; Region: tolA_full; TIGR02794 1162668003473 TonB C terminal; Region: TonB_2; pfam13103 1162668003474 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1162668003475 TolR protein; Region: tolR; TIGR02801 1162668003476 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 1162668003477 Protein of unknown function (DUF3680); Region: DUF3680; pfam12441 1162668003478 Protein of unknown function (DUF497); Region: DUF497; cl01108 1162668003479 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1162668003480 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1162668003481 Protein of unknown function (DUF3423); Region: DUF3423; pfam11903 1162668003482 Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604 1162668003483 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 1162668003484 copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783 1162668003485 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1162668003486 HlyD family secretion protein; Region: HlyD_3; pfam13437 1162668003487 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 1162668003488 Protein of unknown function (DUF1778); Region: DUF1778; pfam08681 1162668003489 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4634 1162668003490 Uncharacterized conserved protein [Function unknown]; Region: COG2442 1162668003491 Uncharacterized protein family, UPF0114; Region: UPF0114; pfam03350 1162668003492 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1162668003493 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 1162668003494 Probable transposase; Region: OrfB_IS605; pfam01385 1162668003495 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1162668003496 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 1162668003497 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 1162668003498 PYR/PP interface [polypeptide binding]; other site 1162668003499 dimer interface [polypeptide binding]; other site 1162668003500 tetramer interface [polypeptide binding]; other site 1162668003501 TPP binding site [chemical binding]; other site 1162668003502 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1162668003503 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1162668003504 TPP-binding site [chemical binding]; other site 1162668003505 Up-frameshift suppressor 2; Region: Upf2; pfam04050 1162668003506 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 1162668003507 Probable transposase; Region: OrfB_IS605; pfam01385 1162668003508 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1162668003509 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 1162668003510 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 1162668003511 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 1162668003512 HipA N-terminal domain; Region: Couple_hipA; pfam13657 1162668003513 HipA-like N-terminal domain; Region: HipA_N; pfam07805 1162668003514 HipA-like C-terminal domain; Region: HipA_C; pfam07804 1162668003515 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1162668003516 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1162668003517 non-specific DNA binding site [nucleotide binding]; other site 1162668003518 salt bridge; other site 1162668003519 sequence-specific DNA binding site [nucleotide binding]; other site 1162668003520 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1162668003521 MULE transposase domain; Region: MULE; pfam10551 1162668003522 Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; pfam09907 1162668003523 Predicted transcription regulator containing HTH domain [Transcription]; Region: COG5499 1162668003524 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 1162668003525 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 1162668003526 putative active site [active] 1162668003527 putative NTP binding site [chemical binding]; other site 1162668003528 putative nucleic acid binding site [nucleotide binding]; other site 1162668003529 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 1162668003530 PIN domain; Region: PIN_3; pfam13470 1162668003531 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; cl17304 1162668003532 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1162668003533 putative active site [active] 1162668003534 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 1162668003535 Galactose oxidase, central domain; Region: Kelch_3; cl02701 1162668003536 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 1162668003537 Kelch domain; Region: Kelch; smart00612 1162668003538 Kelch motif; Region: Kelch_1; pfam01344 1162668003539 Kelch domain; Region: Kelch; smart00612 1162668003540 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1162668003541 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 1162668003542 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1162668003543 active site 1162668003544 Winged helix-turn helix; Region: HTH_29; pfam13551 1162668003545 Homeodomain-like domain; Region: HTH_23; pfam13384 1162668003546 Integrase core domain; Region: rve; pfam00665 1162668003547 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1162668003548 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14612 1162668003549 Integrase core domain; Region: rve; pfam00665 1162668003550 Integrase core domain; Region: rve_3; pfam13683 1162668003551 Integrase core domain; Region: rve; pfam00665 1162668003552 Integrase core domain; Region: rve_3; pfam13683 1162668003553 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cl10029 1162668003554 Homeodomain-like domain; Region: HTH_32; pfam13565 1162668003555 Transposase; Region: HTH_Tnp_1; cl17663 1162668003556 N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655 1162668003557 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 1162668003558 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 1162668003559 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1162668003560 MULE transposase domain; Region: MULE; pfam10551 1162668003561 Integrase core domain; Region: rve; pfam00665 1162668003562 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1162668003563 Integrase core domain; Region: rve; pfam00665 1162668003564 VITF-3 subunit protein; Region: Pox_A8; pfam04745 1162668003565 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1162668003566 Domain of unknown function (DUF4277); Region: DUF4277; pfam14104 1162668003567 Transposase [DNA replication, recombination, and repair]; Region: COG5421 1162668003568 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 1162668003569 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 1162668003570 NADP binding site [chemical binding]; other site 1162668003571 active site 1162668003572 putative substrate binding site [chemical binding]; other site 1162668003573 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 1162668003574 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1162668003575 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1162668003576 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 1162668003577 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1162668003578 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1162668003579 active site 1162668003580 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1162668003581 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1162668003582 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1162668003583 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 1162668003584 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 1162668003585 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 1162668003586 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 1162668003587 Walker A/P-loop; other site 1162668003588 ATP binding site [chemical binding]; other site 1162668003589 Q-loop/lid; other site 1162668003590 ABC transporter signature motif; other site 1162668003591 Walker B; other site 1162668003592 D-loop; other site 1162668003593 H-loop/switch region; other site 1162668003594 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 1162668003595 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1162668003596 potential frameshift: common BLAST hit: gi|189425599|ref|YP_001952776.1| 2-hydroxyglutarate dehydrogenase 1162668003597 Predicted dehydrogenase [General function prediction only]; Region: COG0579 1162668003598 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1162668003599 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1162668003600 glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182 1162668003601 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1162668003602 Ligand binding site; other site 1162668003603 Putative Catalytic site; other site 1162668003604 DXD motif; other site 1162668003605 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1162668003606 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 1162668003607 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 1162668003608 putative active site [active] 1162668003609 homotetrameric interface [polypeptide binding]; other site 1162668003610 metal binding site [ion binding]; metal-binding site 1162668003611 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 1162668003612 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 1162668003613 Fic/DOC family; Region: Fic; pfam02661 1162668003614 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1162668003615 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1162668003616 putative DNA binding site [nucleotide binding]; other site 1162668003617 putative Zn2+ binding site [ion binding]; other site 1162668003618 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1162668003619 dimerization interface [polypeptide binding]; other site 1162668003620 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1162668003621 EamA-like transporter family; Region: EamA; pfam00892 1162668003622 acid phosphatase, Burkholderia-type; Region: acid_phos_Burk; TIGR03397 1162668003623 HeH/LEM domain; Region: HeH; pfam12949 1162668003624 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1162668003625 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1162668003626 S-adenosylmethionine binding site [chemical binding]; other site 1162668003627 RNA polymerase sigma factor SigZ; Provisional; Region: PRK09637 1162668003628 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1162668003629 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1162668003630 DNA binding residues [nucleotide binding] 1162668003631 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 1162668003632 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1162668003633 active site 1162668003634 phosphorylation site [posttranslational modification] 1162668003635 intermolecular recognition site; other site 1162668003636 dimerization interface [polypeptide binding]; other site 1162668003637 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1162668003638 Zn2+ binding site [ion binding]; other site 1162668003639 Mg2+ binding site [ion binding]; other site 1162668003640 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1162668003641 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1162668003642 active site 1162668003643 phosphorylation site [posttranslational modification] 1162668003644 intermolecular recognition site; other site 1162668003645 dimerization interface [polypeptide binding]; other site 1162668003646 CHASE3 domain; Region: CHASE3; pfam05227 1162668003647 GAF domain; Region: GAF_2; pfam13185 1162668003648 GAF domain; Region: GAF_3; pfam13492 1162668003649 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1162668003650 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1162668003651 dimer interface [polypeptide binding]; other site 1162668003652 phosphorylation site [posttranslational modification] 1162668003653 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1162668003654 ATP binding site [chemical binding]; other site 1162668003655 Mg2+ binding site [ion binding]; other site 1162668003656 G-X-G motif; other site 1162668003657 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1162668003658 active site 1162668003659 phosphorylation site [posttranslational modification] 1162668003660 intermolecular recognition site; other site 1162668003661 dimerization interface [polypeptide binding]; other site 1162668003662 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1162668003663 active site 1162668003664 phosphorylation site [posttranslational modification] 1162668003665 intermolecular recognition site; other site 1162668003666 dimerization interface [polypeptide binding]; other site 1162668003667 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1162668003668 S-adenosylmethionine binding site [chemical binding]; other site 1162668003669 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 1162668003670 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1162668003671 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1162668003672 FeS/SAM binding site; other site 1162668003673 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 1162668003674 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 1162668003675 Predicted permeases [General function prediction only]; Region: COG0795 1162668003676 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 1162668003677 Ferrochelatase; Region: Ferrochelatase; pfam00762 1162668003678 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 1162668003679 C-terminal domain interface [polypeptide binding]; other site 1162668003680 active site 1162668003681 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 1162668003682 active site 1162668003683 N-terminal domain interface [polypeptide binding]; other site 1162668003684 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1162668003685 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1162668003686 active site 1162668003687 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1162668003688 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1162668003689 active site 1162668003690 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 1162668003691 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1162668003692 ATP binding site [chemical binding]; other site 1162668003693 Mg++ binding site [ion binding]; other site 1162668003694 motif III; other site 1162668003695 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1162668003696 nucleotide binding region [chemical binding]; other site 1162668003697 ATP-binding site [chemical binding]; other site 1162668003698 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1162668003699 Protein of unknown function (DUF1778); Region: DUF1778; pfam08681 1162668003700 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 1162668003701 TPR repeat; Region: TPR_11; pfam13414 1162668003702 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1162668003703 binding surface 1162668003704 TPR motif; other site 1162668003705 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1162668003706 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1162668003707 catalytic loop [active] 1162668003708 iron binding site [ion binding]; other site 1162668003709 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1162668003710 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1162668003711 non-specific DNA binding site [nucleotide binding]; other site 1162668003712 salt bridge; other site 1162668003713 sequence-specific DNA binding site [nucleotide binding]; other site 1162668003714 Domain of unknown function (DUF955); Region: DUF955; cl01076 1162668003715 PIN domain; Region: PIN; pfam01850 1162668003716 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 1162668003717 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 1162668003718 B12 binding site [chemical binding]; other site 1162668003719 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1162668003720 FeS/SAM binding site; other site 1162668003721 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1162668003722 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 1162668003723 Undecaprenyl-phosphate galactose phosphotransferase, WbaP; Region: WbaP_sugtrans; TIGR03022 1162668003724 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1162668003725 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348 1162668003726 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 1162668003727 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1162668003728 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1162668003729 dimer interface [polypeptide binding]; other site 1162668003730 putative anticodon binding site; other site 1162668003731 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 1162668003732 motif 1; other site 1162668003733 active site 1162668003734 motif 2; other site 1162668003735 motif 3; other site 1162668003736 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 1162668003737 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1162668003738 FtsX-like permease family; Region: FtsX; pfam02687 1162668003739 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1162668003740 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1162668003741 Walker A/P-loop; other site 1162668003742 ATP binding site [chemical binding]; other site 1162668003743 Q-loop/lid; other site 1162668003744 ABC transporter signature motif; other site 1162668003745 Walker B; other site 1162668003746 D-loop; other site 1162668003747 H-loop/switch region; other site 1162668003748 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 1162668003749 ferredoxin--nitrite reductase; Region: PLN02431 1162668003750 aspartate aminotransferase; Provisional; Region: PRK05764 1162668003751 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1162668003752 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1162668003753 homodimer interface [polypeptide binding]; other site 1162668003754 catalytic residue [active] 1162668003755 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1162668003756 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1162668003757 active site 1162668003758 (T/H)XGH motif; other site 1162668003759 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 1162668003760 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1162668003761 S-adenosylmethionine binding site [chemical binding]; other site 1162668003762 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1162668003763 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 1162668003764 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1162668003765 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1162668003766 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1162668003767 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1162668003768 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1162668003769 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1162668003770 purine monophosphate binding site [chemical binding]; other site 1162668003771 dimer interface [polypeptide binding]; other site 1162668003772 putative catalytic residues [active] 1162668003773 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1162668003774 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 1162668003775 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 1162668003776 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 1162668003777 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 1162668003778 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 1162668003779 Ligand binding site; other site 1162668003780 Putative Catalytic site; other site 1162668003781 DXD motif; other site 1162668003782 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1162668003783 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1162668003784 putative active site [active] 1162668003785 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 1162668003786 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 1162668003787 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1162668003788 active site 1162668003789 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 1162668003790 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 1162668003791 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1162668003792 trimer interface [polypeptide binding]; other site 1162668003793 active site 1162668003794 substrate binding site [chemical binding]; other site 1162668003795 CoA binding site [chemical binding]; other site 1162668003796 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 1162668003797 homotrimer interaction site [polypeptide binding]; other site 1162668003798 zinc binding site [ion binding]; other site 1162668003799 CDP-binding sites; other site 1162668003800 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1162668003801 substrate binding site; other site 1162668003802 dimer interface; other site 1162668003803 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 1162668003804 putative active site [active] 1162668003805 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 1162668003806 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 1162668003807 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1162668003808 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 1162668003809 inhibitor-cofactor binding pocket; inhibition site 1162668003810 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1162668003811 catalytic residue [active] 1162668003812 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 1162668003813 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1162668003814 Protein of unknown function (DUF433); Region: DUF433; pfam04255 1162668003815 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1162668003816 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1162668003817 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1162668003818 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 1162668003819 putative active site [active] 1162668003820 putative metal binding site [ion binding]; other site 1162668003821 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1162668003822 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1162668003823 putative active site [active] 1162668003824 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1162668003825 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1162668003826 putative active site [active] 1162668003827 Trm112p-like protein; Region: Trm112p; cl01066 1162668003828 histidinol-phosphate phosphatase family domain; Region: Histidinol-ppas; TIGR01656 1162668003829 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1162668003830 active site 1162668003831 motif I; other site 1162668003832 motif II; other site 1162668003833 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1162668003834 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1162668003835 putative active site [active] 1162668003836 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1162668003837 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1162668003838 active site 1162668003839 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1162668003840 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1162668003841 active site 1162668003842 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1162668003843 active site 1162668003844 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1162668003845 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1162668003846 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1162668003847 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 1162668003848 putative metal binding site; other site 1162668003849 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1162668003850 MULE transposase domain; Region: MULE; pfam10551 1162668003851 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1162668003852 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1162668003853 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1162668003854 putative active site [active] 1162668003855 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1162668003856 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1162668003857 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1162668003858 putative active site [active] 1162668003859 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 1162668003860 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1162668003861 putative acyl-acceptor binding pocket; other site 1162668003862 Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; pfam02606 1162668003863 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 1162668003864 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 1162668003865 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1162668003866 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1162668003867 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1162668003868 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1162668003869 Walker A/P-loop; other site 1162668003870 ATP binding site [chemical binding]; other site 1162668003871 Q-loop/lid; other site 1162668003872 ABC transporter signature motif; other site 1162668003873 Walker B; other site 1162668003874 D-loop; other site 1162668003875 H-loop/switch region; other site 1162668003876 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 1162668003877 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 1162668003878 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1162668003879 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1162668003880 Protein of unknown function (DUF1009); Region: DUF1009; pfam06230 1162668003881 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 1162668003882 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 1162668003883 active site 1162668003884 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1162668003885 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 1162668003886 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 1162668003887 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 1162668003888 trimer interface [polypeptide binding]; other site 1162668003889 active site 1162668003890 UDP-GlcNAc binding site [chemical binding]; other site 1162668003891 lipid binding site [chemical binding]; lipid-binding site 1162668003892 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 1162668003893 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 1162668003894 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1162668003895 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1162668003896 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1162668003897 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1162668003898 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1162668003899 Surface antigen; Region: Bac_surface_Ag; pfam01103 1162668003900 cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913 1162668003901 Precorrin-8X methylmutase; Region: CbiC; pfam02570 1162668003902 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 1162668003903 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1162668003904 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 1162668003905 catalytic triad [active] 1162668003906 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1162668003907 catalytic core [active] 1162668003908 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 1162668003909 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1162668003910 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1162668003911 active site 1162668003912 catalytic tetrad [active] 1162668003913 cobalamin synthase; Reviewed; Region: cobS; PRK00235 1162668003914 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 1162668003915 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 1162668003916 putative dimer interface [polypeptide binding]; other site 1162668003917 active site pocket [active] 1162668003918 putative cataytic base [active] 1162668003919 Cobinamide kinase / cobinamide phosphate guanyltransferase; Region: CobU; pfam02283 1162668003920 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1162668003921 RDD family; Region: RDD; cl00746 1162668003922 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 1162668003923 RNA methyltransferase, RsmE family; Region: TIGR00046 1162668003924 chaperone protein DnaJ; Provisional; Region: PRK10767 1162668003925 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1162668003926 HSP70 interaction site [polypeptide binding]; other site 1162668003927 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1162668003928 Zn binding sites [ion binding]; other site 1162668003929 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1162668003930 dimer interface [polypeptide binding]; other site 1162668003931 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1162668003932 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 1162668003933 nucleotide binding site [chemical binding]; other site 1162668003934 NEF interaction site [polypeptide binding]; other site 1162668003935 SBD interface [polypeptide binding]; other site 1162668003936 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 1162668003937 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1162668003938 dimer interface [polypeptide binding]; other site 1162668003939 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1162668003940 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 1162668003941 Ribosomal protein S19e; Region: Ribosomal_S19e; cl00969 1162668003942 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1162668003943 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1162668003944 putative substrate translocation pore; other site 1162668003945 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 1162668003946 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1162668003947 HlyD family secretion protein; Region: HlyD_3; pfam13437 1162668003948 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 1162668003949 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1162668003950 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1162668003951 putative substrate translocation pore; other site 1162668003952 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 1162668003953 HlyD family secretion protein; Region: HlyD_3; pfam13437 1162668003954 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 1162668003955 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1162668003956 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 1162668003957 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1162668003958 GAF domain; Region: GAF_2; pfam13185 1162668003959 GAF domain; Region: GAF; pfam01590 1162668003960 ANTAR domain; Region: ANTAR; pfam03861 1162668003961 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1162668003962 active site 1162668003963 dimer interface [polypeptide binding]; other site 1162668003964 metal binding site [ion binding]; metal-binding site 1162668003965 shikimate kinase; Reviewed; Region: aroK; PRK00131 1162668003966 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1162668003967 ADP binding site [chemical binding]; other site 1162668003968 magnesium binding site [ion binding]; other site 1162668003969 putative shikimate binding site; other site 1162668003970 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1162668003971 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 1162668003972 Tetramer interface [polypeptide binding]; other site 1162668003973 active site 1162668003974 FMN-binding site [chemical binding]; other site 1162668003975 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 1162668003976 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1162668003977 30S subunit binding site; other site 1162668003978 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 1162668003979 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 1162668003980 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 1162668003981 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 1162668003982 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 1162668003983 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 1162668003984 Walker A/P-loop; other site 1162668003985 ATP binding site [chemical binding]; other site 1162668003986 Q-loop/lid; other site 1162668003987 ABC transporter signature motif; other site 1162668003988 Walker B; other site 1162668003989 D-loop; other site 1162668003990 H-loop/switch region; other site 1162668003991 OstA-like protein; Region: OstA; pfam03968 1162668003992 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 1162668003993 malate dehydrogenase; Reviewed; Region: PRK06223 1162668003994 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 1162668003995 NAD(P) binding site [chemical binding]; other site 1162668003996 dimer interface [polypeptide binding]; other site 1162668003997 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1162668003998 substrate binding site [chemical binding]; other site 1162668003999 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1162668004000 putative substrate translocation pore; other site 1162668004001 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1162668004002 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1162668004003 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 1162668004004 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 1162668004005 HlyD family secretion protein; Region: HlyD_3; pfam13437 1162668004006 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 1162668004007 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 1162668004008 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905 1162668004009 Type III pantothenate kinase; Region: Pan_kinase; cl17198 1162668004010 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 1162668004011 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 1162668004012 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 1162668004013 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 1162668004014 dimerization interface [polypeptide binding]; other site 1162668004015 active site 1162668004016 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1162668004017 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1162668004018 active site 1162668004019 HIGH motif; other site 1162668004020 nucleotide binding site [chemical binding]; other site 1162668004021 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1162668004022 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1162668004023 active site 1162668004024 KMSKS motif; other site 1162668004025 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1162668004026 tRNA binding surface [nucleotide binding]; other site 1162668004027 anticodon binding site; other site 1162668004028 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1162668004029 Cyd operon protein YbgE (Cyd_oper_YbgE); Region: Cyd_oper_YbgE; cl11451 1162668004030 YceG-like family; Region: YceG; pfam02618 1162668004031 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 1162668004032 dimerization interface [polypeptide binding]; other site 1162668004033 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 1162668004034 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1162668004035 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1162668004036 motif 1; other site 1162668004037 active site 1162668004038 motif 2; other site 1162668004039 motif 3; other site 1162668004040 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1162668004041 DHHA1 domain; Region: DHHA1; pfam02272 1162668004042 recombinase A; Provisional; Region: recA; PRK09354 1162668004043 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1162668004044 hexamer interface [polypeptide binding]; other site 1162668004045 Walker A motif; other site 1162668004046 ATP binding site [chemical binding]; other site 1162668004047 Walker B motif; other site 1162668004048 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 1162668004049 tetramer interfaces [polypeptide binding]; other site 1162668004050 binuclear metal-binding site [ion binding]; other site 1162668004051 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cl11423 1162668004052 S-adenosylmethionine decarboxylase proenzyme, Bacillus form; Region: SAM_DCase_Bsu; TIGR03330 1162668004053 spermine synthase; Region: PLN02823 1162668004054 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1162668004055 S-adenosylmethionine binding site [chemical binding]; other site 1162668004056 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 1162668004057 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 1162668004058 homodimer interface [polypeptide binding]; other site 1162668004059 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1162668004060 catalytic residue [active] 1162668004061 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1162668004062 Uncharacterized conserved protein [Function unknown]; Region: COG1615 1162668004063 Uncharacterized protein family (UPF0182); Region: UPF0182; pfam03699 1162668004064 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 1162668004065 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1162668004066 Walker A/P-loop; other site 1162668004067 ATP binding site [chemical binding]; other site 1162668004068 Q-loop/lid; other site 1162668004069 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1162668004070 ABC transporter signature motif; other site 1162668004071 Walker B; other site 1162668004072 D-loop; other site 1162668004073 H-loop/switch region; other site 1162668004074 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1162668004075 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1162668004076 catalytic residues [active] 1162668004077 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1162668004078 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1162668004079 ring oligomerisation interface [polypeptide binding]; other site 1162668004080 ATP/Mg binding site [chemical binding]; other site 1162668004081 stacking interactions; other site 1162668004082 hinge regions; other site 1162668004083 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1162668004084 oligomerisation interface [polypeptide binding]; other site 1162668004085 mobile loop; other site 1162668004086 roof hairpin; other site 1162668004087 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 1162668004088 C-terminal peptidase (prc); Region: prc; TIGR00225 1162668004089 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1162668004090 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1162668004091 Catalytic dyad [active] 1162668004092 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1162668004093 Peptidase family M23; Region: Peptidase_M23; pfam01551 1162668004094 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 1162668004095 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1162668004096 RNA/DNA hybrid binding site [nucleotide binding]; other site 1162668004097 active site 1162668004098 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1162668004099 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1162668004100 RimM N-terminal domain; Region: RimM; pfam01782 1162668004101 PRC-barrel domain; Region: PRC; pfam05239 1162668004102 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 1162668004103 signal recognition particle protein; Provisional; Region: PRK10867 1162668004104 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1162668004105 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1162668004106 P loop; other site 1162668004107 GTP binding site [chemical binding]; other site 1162668004108 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1162668004109 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1162668004110 IHF dimer interface [polypeptide binding]; other site 1162668004111 IHF - DNA interface [nucleotide binding]; other site 1162668004112 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 1162668004113 oligomer interface [polypeptide binding]; other site 1162668004114 tandem repeat interface [polypeptide binding]; other site 1162668004115 active site residues [active] 1162668004116 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 1162668004117 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1162668004118 RNA binding site [nucleotide binding]; other site 1162668004119 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1162668004120 RNA binding site [nucleotide binding]; other site 1162668004121 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 1162668004122 RNA binding site [nucleotide binding]; other site 1162668004123 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1162668004124 RNA binding site [nucleotide binding]; other site 1162668004125 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 1162668004126 RNA binding site [nucleotide binding]; other site 1162668004127 S1 RNA binding domain; Region: S1; pfam00575 1162668004128 RNA binding site [nucleotide binding]; other site 1162668004129 DNA polymerase type-B family catalytic domain. DNA-directed DNA polymerases elongate DNA by adding nucleotide triphosphate (dNTP) residues to the 5'-end of the growing chain of DNA. DNA-directed DNA polymerases are multifunctional with both...; Region: POLBc; cl10023 1162668004130 active site 1162668004131 metal-binding site 1162668004132 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1162668004133 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 1162668004134 Probable transposase; Region: OrfB_IS605; pfam01385 1162668004135 Phospholipid methyltransferase; Region: PEMT; cl17370 1162668004136 S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887 1162668004137 Galactose oxidase, central domain; Region: Kelch_3; cl02701 1162668004138 Kelch domain; Region: Kelch; smart00612 1162668004139 Kelch motif; Region: Kelch_1; pfam01344 1162668004140 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 1162668004141 Galactose oxidase, central domain; Region: Kelch_3; cl02701 1162668004142 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1162668004143 Sel1 repeat; Region: Sel1; pfam08238 1162668004144 Sel1-like repeats; Region: SEL1; smart00671 1162668004145 Sel1-like repeats; Region: SEL1; smart00671 1162668004146 Caspase domain; Region: Peptidase_C14; pfam00656 1162668004147 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1162668004148 metal binding site 2 [ion binding]; metal-binding site 1162668004149 putative DNA binding helix; other site 1162668004150 metal binding site 1 [ion binding]; metal-binding site 1162668004151 dimer interface [polypeptide binding]; other site 1162668004152 structural Zn2+ binding site [ion binding]; other site 1162668004153 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1162668004154 Protein export membrane protein; Region: SecD_SecF; cl14618 1162668004155 Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098 1162668004156 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1162668004157 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 1162668004158 active site 1162668004159 NTP binding site [chemical binding]; other site 1162668004160 metal binding triad [ion binding]; metal-binding site 1162668004161 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 1162668004162 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1162668004163 TPR motif; other site 1162668004164 binding surface 1162668004165 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1162668004166 binding surface 1162668004167 TPR motif; other site 1162668004168 TPR repeat; Region: TPR_11; pfam13414 1162668004169 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1162668004170 binding surface 1162668004171 TPR motif; other site 1162668004172 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1162668004173 TPR motif; other site 1162668004174 binding surface 1162668004175 exopolyphosphatase; Region: exo_poly_only; TIGR03706 1162668004176 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1162668004177 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 1162668004178 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1162668004179 ssDNA binding site; other site 1162668004180 generic binding surface II; other site 1162668004181 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1162668004182 ATP binding site [chemical binding]; other site 1162668004183 putative Mg++ binding site [ion binding]; other site 1162668004184 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1162668004185 nucleotide binding region [chemical binding]; other site 1162668004186 ATP-binding site [chemical binding]; other site 1162668004187 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1162668004188 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1162668004189 metal binding site [ion binding]; metal-binding site 1162668004190 active site 1162668004191 I-site; other site 1162668004192 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1162668004193 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1162668004194 homotrimer interaction site [polypeptide binding]; other site 1162668004195 putative active site [active] 1162668004196 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1162668004197 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 1162668004198 interchain domain interface [polypeptide binding]; other site 1162668004199 intrachain domain interface; other site 1162668004200 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 1162668004201 heme bH binding site [chemical binding]; other site 1162668004202 Qi binding site; other site 1162668004203 heme bL binding site [chemical binding]; other site 1162668004204 Qo binding site; other site 1162668004205 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193 1162668004206 intrachain domain interface; other site 1162668004207 Qi binding site; other site 1162668004208 Qo binding site; other site 1162668004209 Cytochrome c; Region: Cytochrom_C; pfam00034 1162668004210 ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416 1162668004211 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 1162668004212 iron-sulfur cluster [ion binding]; other site 1162668004213 [2Fe-2S] cluster binding site [ion binding]; other site 1162668004214 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 1162668004215 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 1162668004216 NAD binding site [chemical binding]; other site 1162668004217 homotetramer interface [polypeptide binding]; other site 1162668004218 homodimer interface [polypeptide binding]; other site 1162668004219 substrate binding site [chemical binding]; other site 1162668004220 active site 1162668004221 Uncharacterized conserved protein [Function unknown]; Region: COG3391 1162668004222 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 1162668004223 MutS domain I; Region: MutS_I; pfam01624 1162668004224 MutS domain II; Region: MutS_II; pfam05188 1162668004225 MutS domain III; Region: MutS_III; pfam05192 1162668004226 MutS domain V; Region: MutS_V; pfam00488 1162668004227 Walker A/P-loop; other site 1162668004228 ATP binding site [chemical binding]; other site 1162668004229 Q-loop/lid; other site 1162668004230 ABC transporter signature motif; other site 1162668004231 Walker B; other site 1162668004232 D-loop; other site 1162668004233 H-loop/switch region; other site 1162668004234 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 1162668004235 Fe-S cluster binding site [ion binding]; other site 1162668004236 active site 1162668004237 Uncharacterized conserved protein [Function unknown]; Region: COG0062 1162668004238 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1162668004239 putative substrate binding site [chemical binding]; other site 1162668004240 putative ATP binding site [chemical binding]; other site 1162668004241 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 1162668004242 pyridoxine 5'-phosphate synthase; Provisional; Region: PRK05265 1162668004243 active site 1162668004244 hydrophilic channel; other site 1162668004245 dimerization interface [polypeptide binding]; other site 1162668004246 catalytic residues [active] 1162668004247 active site lid [active] 1162668004248 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1162668004249 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1162668004250 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1162668004251 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1162668004252 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1162668004253 N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655 1162668004254 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 1162668004255 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 1162668004256 putative active site [active] 1162668004257 putative NTP binding site [chemical binding]; other site 1162668004258 putative nucleic acid binding site [nucleotide binding]; other site 1162668004259 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 1162668004260 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1162668004261 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 1162668004262 Integrase core domain; Region: rve; pfam00665 1162668004263 transposase/IS protein; Provisional; Region: PRK09183 1162668004264 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1162668004265 Walker A motif; other site 1162668004266 ATP binding site [chemical binding]; other site 1162668004267 Walker B motif; other site 1162668004268 arginine finger; other site 1162668004269 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1162668004270 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1162668004271 Transposase IS200 like; Region: Y1_Tnp; pfam01797 1162668004272 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1162668004273 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1162668004274 Probable transposase; Region: OrfB_IS605; pfam01385 1162668004275 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1162668004276 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 1162668004277 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 1162668004278 RNase E interface [polypeptide binding]; other site 1162668004279 trimer interface [polypeptide binding]; other site 1162668004280 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1162668004281 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1162668004282 RNase E interface [polypeptide binding]; other site 1162668004283 trimer interface [polypeptide binding]; other site 1162668004284 active site 1162668004285 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1162668004286 putative nucleic acid binding region [nucleotide binding]; other site 1162668004287 G-X-X-G motif; other site 1162668004288 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1162668004289 RNA binding site [nucleotide binding]; other site 1162668004290 domain interface; other site 1162668004291 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1162668004292 16S/18S rRNA binding site [nucleotide binding]; other site 1162668004293 S13e-L30e interaction site [polypeptide binding]; other site 1162668004294 25S rRNA binding site [nucleotide binding]; other site 1162668004295 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1162668004296 tRNA pseudouridine(55) synthase; Region: TruB; TIGR00431 1162668004297 RNA binding site [nucleotide binding]; other site 1162668004298 active site 1162668004299 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1162668004300 translation initiation factor IF-2; Region: IF-2; TIGR00487 1162668004301 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1162668004302 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1162668004303 G1 box; other site 1162668004304 putative GEF interaction site [polypeptide binding]; other site 1162668004305 GTP/Mg2+ binding site [chemical binding]; other site 1162668004306 Switch I region; other site 1162668004307 G2 box; other site 1162668004308 G3 box; other site 1162668004309 Switch II region; other site 1162668004310 G4 box; other site 1162668004311 G5 box; other site 1162668004312 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1162668004313 Translation-initiation factor 2; Region: IF-2; pfam11987 1162668004314 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1162668004315 transcription termination factor NusA; Region: NusA; TIGR01953 1162668004316 NusA N-terminal domain; Region: NusA_N; pfam08529 1162668004317 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1162668004318 RNA binding site [nucleotide binding]; other site 1162668004319 homodimer interface [polypeptide binding]; other site 1162668004320 NusA-like KH domain; Region: KH_5; pfam13184 1162668004321 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1162668004322 G-X-X-G motif; other site 1162668004323 Sm and related proteins; Region: Sm_like; cl00259 1162668004324 Uncharacterized BCR, YhbC family COG0779; Region: DUF150; pfam02576 1162668004325 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 1162668004326 putative oligomer interface [polypeptide binding]; other site 1162668004327 putative RNA binding site [nucleotide binding]; other site 1162668004328 Domain of unknown function (DUF4337); Region: DUF4337; pfam14235 1162668004329 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 1162668004330 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1162668004331 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1162668004332 active site 1162668004333 phosphorylation site [posttranslational modification] 1162668004334 intermolecular recognition site; other site 1162668004335 dimerization interface [polypeptide binding]; other site 1162668004336 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1162668004337 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1162668004338 Coenzyme A binding pocket [chemical binding]; other site 1162668004339 SnoaL-like domain; Region: SnoaL_2; pfam12680 1162668004340 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3558 1162668004341 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 1162668004342 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1162668004343 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1162668004344 Coenzyme A binding pocket [chemical binding]; other site 1162668004345 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1162668004346 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1162668004347 Isochorismatase family; Region: Isochorismatase; pfam00857 1162668004348 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 1162668004349 catalytic triad [active] 1162668004350 conserved cis-peptide bond; other site 1162668004351 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1162668004352 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1162668004353 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 1162668004354 SnoaL-like domain; Region: SnoaL_3; pfam13474 1162668004355 AAA domain; Region: AAA_33; pfam13671 1162668004356 AAA domain; Region: AAA_17; pfam13207 1162668004357 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 1162668004358 active site 1 [active] 1162668004359 dimer interface [polypeptide binding]; other site 1162668004360 hexamer interface [polypeptide binding]; other site 1162668004361 active site 2 [active] 1162668004362 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1162668004363 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1162668004364 substrate binding site [chemical binding]; other site 1162668004365 EthD domain; Region: EthD; pfam07110 1162668004366 Protein of unknown function (DUF3995); Region: DUF3995; pfam13160 1162668004367 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 1162668004368 Autoinducer binding domain; Region: Autoind_bind; pfam03472 1162668004369 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1162668004370 DNA binding residues [nucleotide binding] 1162668004371 dimerization interface [polypeptide binding]; other site 1162668004372 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1162668004373 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1162668004374 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 1162668004375 uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228 1162668004376 putative NADP binding site [chemical binding]; other site 1162668004377 putative substrate binding site [chemical binding]; other site 1162668004378 active site 1162668004379 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1162668004380 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1162668004381 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 1162668004382 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1162668004383 DNA binding site [nucleotide binding] 1162668004384 active site 1162668004385 acetylornithine transaminase protein; Provisional; Region: argD; PRK03715 1162668004386 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1162668004387 inhibitor-cofactor binding pocket; inhibition site 1162668004388 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1162668004389 catalytic residue [active] 1162668004390 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1162668004391 Predicted transcriptional regulator [Transcription]; Region: COG1959 1162668004392 Transcriptional regulator; Region: Rrf2; pfam02082 1162668004393 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1162668004394 putative DNA binding site [nucleotide binding]; other site 1162668004395 putative Zn2+ binding site [ion binding]; other site 1162668004396 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1162668004397 S-adenosylmethionine binding site [chemical binding]; other site 1162668004398 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_4; cd07822 1162668004399 putative hydrophobic ligand binding site [chemical binding]; other site 1162668004400 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1162668004401 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1162668004402 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1162668004403 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1162668004404 MarR family; Region: MarR_2; cl17246 1162668004405 EVE domain; Region: EVE; cl00728 1162668004406 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1162668004407 hydrophobic ligand binding site; other site 1162668004408 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1162668004409 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1162668004410 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1162668004411 putative substrate translocation pore; other site 1162668004412 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1162668004413 Thioredoxin; Region: Thioredoxin_4; cl17273 1162668004414 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 1162668004415 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 1162668004416 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 1162668004417 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1162668004418 Ligand Binding Site [chemical binding]; other site 1162668004419 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1162668004420 PhoH-like protein; Region: PhoH; pfam02562 1162668004421 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1162668004422 Zn2+ binding site [ion binding]; other site 1162668004423 Mg2+ binding site [ion binding]; other site 1162668004424 Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130 1162668004425 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 1162668004426 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 1162668004427 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1162668004428 P loop; other site 1162668004429 GTP binding site [chemical binding]; other site 1162668004430 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 1162668004431 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1162668004432 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1162668004433 shikimate binding site; other site 1162668004434 NAD(P) binding site [chemical binding]; other site 1162668004435 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1162668004436 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1162668004437 GIY-YIG motif/motif A; other site 1162668004438 active site 1162668004439 catalytic site [active] 1162668004440 putative DNA binding site [nucleotide binding]; other site 1162668004441 metal binding site [ion binding]; metal-binding site 1162668004442 UvrB/uvrC motif; Region: UVR; pfam02151 1162668004443 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1162668004444 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1162668004445 ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464 1162668004446 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1162668004447 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 1162668004448 Walker A motif; other site 1162668004449 ATP binding site [chemical binding]; other site 1162668004450 Walker B motif; other site 1162668004451 arginine finger; other site 1162668004452 thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190 1162668004453 ThiC family; Region: ThiC; pfam01964 1162668004454 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 1162668004455 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 1162668004456 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 1162668004457 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 1162668004458 substrate binding pocket [chemical binding]; other site 1162668004459 dimer interface [polypeptide binding]; other site 1162668004460 inhibitor binding site; inhibition site 1162668004461 Predicted cobalamin binding protein [General function prediction only]; Region: COG5012 1162668004462 B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or...; Region: corrinoid_protein_B12-BD; cd02070 1162668004463 B12 binding site [chemical binding]; other site 1162668004464 cobalt ligand [ion binding]; other site 1162668004465 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 1162668004466 putative hydrolase; Provisional; Region: PRK02113 1162668004467 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1162668004468 active site 1162668004469 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 1162668004470 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1162668004471 G1 box; other site 1162668004472 putative GEF interaction site [polypeptide binding]; other site 1162668004473 GTP/Mg2+ binding site [chemical binding]; other site 1162668004474 Switch I region; other site 1162668004475 G2 box; other site 1162668004476 G3 box; other site 1162668004477 Switch II region; other site 1162668004478 G4 box; other site 1162668004479 G5 box; other site 1162668004480 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1162668004481 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1162668004482 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 1162668004483 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 1162668004484 putative RNA binding site [nucleotide binding]; other site 1162668004485 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1162668004486 S-adenosylmethionine binding site [chemical binding]; other site 1162668004487 Recombination protein O N terminal; Region: RecO_N; pfam11967 1162668004488 DNA repair protein RecO; Region: reco; TIGR00613 1162668004489 Recombination protein O C terminal; Region: RecO_C; pfam02565 1162668004490 GTPase Era; Reviewed; Region: era; PRK00089 1162668004491 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1162668004492 G1 box; other site 1162668004493 GTP/Mg2+ binding site [chemical binding]; other site 1162668004494 Switch I region; other site 1162668004495 G2 box; other site 1162668004496 Switch II region; other site 1162668004497 G3 box; other site 1162668004498 G4 box; other site 1162668004499 G5 box; other site 1162668004500 KH domain; Region: KH_2; pfam07650 1162668004501 short chain dehydrogenase; Provisional; Region: PRK07024 1162668004502 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1162668004503 NAD(P) binding site [chemical binding]; other site 1162668004504 active site 1162668004505 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 1162668004506 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 1162668004507 Substrate binding site; other site 1162668004508 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 1162668004509 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 1162668004510 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 1162668004511 active site 1162668004512 substrate binding site [chemical binding]; other site 1162668004513 metal binding site [ion binding]; metal-binding site 1162668004514 Transcriptional regulator; Region: Rrf2; cl17282 1162668004515 Rrf2 family protein; Region: rrf2_super; TIGR00738 1162668004516 DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753 1162668004517 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1162668004518 ligand binding site [chemical binding]; other site 1162668004519 flexible hinge region; other site 1162668004520 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 1162668004521 AMP-binding enzyme; Region: AMP-binding; pfam00501 1162668004522 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 1162668004523 acyl-activating enzyme (AAE) consensus motif; other site 1162668004524 putative AMP binding site [chemical binding]; other site 1162668004525 putative active site [active] 1162668004526 putative CoA binding site [chemical binding]; other site 1162668004527 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 1162668004528 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1162668004529 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1162668004530 putative acyl-acceptor binding pocket; other site 1162668004531 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 1162668004532 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 1162668004533 Beta-Casp domain; Region: Beta-Casp; smart01027 1162668004534 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1162668004535 exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609 1162668004536 Family description; Region: UvrD_C_2; pfam13538 1162668004537 Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; pfam04257 1162668004538 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 1162668004539 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 1162668004540 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1162668004541 dimer interface [polypeptide binding]; other site 1162668004542 putative CheW interface [polypeptide binding]; other site 1162668004543 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 1162668004544 Iron permease FTR1 family; Region: FTR1; cl00475 1162668004545 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 1162668004546 N-acetylglutamate synthase; Validated; Region: PRK05279 1162668004547 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 1162668004548 putative feedback inhibition sensing region; other site 1162668004549 putative nucleotide binding site [chemical binding]; other site 1162668004550 putative substrate binding site [chemical binding]; other site 1162668004551 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1162668004552 Coenzyme A binding pocket [chemical binding]; other site 1162668004553 MASE1; Region: MASE1; cl17823 1162668004554 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1162668004555 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1162668004556 putative active site [active] 1162668004557 heme pocket [chemical binding]; other site 1162668004558 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1162668004559 putative active site [active] 1162668004560 heme pocket [chemical binding]; other site 1162668004561 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1162668004562 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1162668004563 metal binding site [ion binding]; metal-binding site 1162668004564 active site 1162668004565 I-site; other site 1162668004566 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 1162668004567 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 1162668004568 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 1162668004569 thiS-thiF/thiG interaction site; other site 1162668004570 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 1162668004571 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1162668004572 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 1162668004573 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1162668004574 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1162668004575 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 1162668004576 type II secretion system protein E; Region: type_II_gspE; TIGR02533 1162668004577 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 1162668004578 Walker A motif; other site 1162668004579 ATP binding site [chemical binding]; other site 1162668004580 Walker B motif; other site 1162668004581 type II secretion system protein F; Region: GspF; TIGR02120 1162668004582 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1162668004583 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1162668004584 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 1162668004585 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 1162668004586 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 1162668004587 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 1162668004588 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 1162668004589 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1162668004590 binding surface 1162668004591 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1162668004592 TPR motif; other site 1162668004593 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1162668004594 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1162668004595 binding surface 1162668004596 TPR motif; other site 1162668004597 TPR repeat; Region: TPR_11; pfam13414 1162668004598 Protein of unknown function (DUF692); Region: DUF692; cl01263 1162668004599 Chemotaxis phosphatase, CheZ; Region: CheZ; cl01219 1162668004600 Bacterial Fe(2+) trafficking; Region: Iron_traffic; cl01104 1162668004601 Proline dehydrogenase; Region: Pro_dh; cl03282 1162668004602 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 1162668004603 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1162668004604 ATP binding site [chemical binding]; other site 1162668004605 putative Mg++ binding site [ion binding]; other site 1162668004606 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1162668004607 nucleotide binding region [chemical binding]; other site 1162668004608 ATP-binding site [chemical binding]; other site 1162668004609 LexA repressor; Validated; Region: PRK00215 1162668004610 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 1162668004611 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1162668004612 Catalytic site [active] 1162668004613 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 1162668004614 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1162668004615 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 1162668004616 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1162668004617 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 1162668004618 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 1162668004619 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1162668004620 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 1162668004621 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 1162668004622 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 1162668004623 Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) [Energy production and conversion]; Region: NuoI; COG1143 1162668004624 4Fe-4S binding domain; Region: Fer4; cl02805 1162668004625 4Fe-4S binding domain; Region: Fer4; pfam00037 1162668004626 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 1162668004627 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 1162668004628 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 1162668004629 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1162668004630 molybdopterin cofactor binding site; other site 1162668004631 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cd02775 1162668004632 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 1162668004633 dimer interface [polypeptide binding]; other site 1162668004634 [2Fe-2S] cluster binding site [ion binding]; other site 1162668004635 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 1162668004636 SLBB domain; Region: SLBB; pfam10531 1162668004637 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 1162668004638 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 1162668004639 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 1162668004640 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 1162668004641 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 1162668004642 putative dimer interface [polypeptide binding]; other site 1162668004643 [2Fe-2S] cluster binding site [ion binding]; other site 1162668004644 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 1162668004645 NADH dehydrogenase subunit D; Validated; Region: PRK06075 1162668004646 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 1162668004647 NADH dehydrogenase subunit B; Validated; Region: PRK06411 1162668004648 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 1162668004649 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 1162668004650 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1162668004651 SEC-C motif; Region: SEC-C; pfam02810 1162668004652 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1162668004653 Peptidase family M23; Region: Peptidase_M23; pfam01551 1162668004654 Uncharacterized protein involved in tolerance to divalent cations [Inorganic ion transport and metabolism]; Region: CutA; COG1324 1162668004655 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1162668004656 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1162668004657 NAD(P) binding site [chemical binding]; other site 1162668004658 active site 1162668004659 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 1162668004660 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1162668004661 S-adenosylmethionine binding site [chemical binding]; other site 1162668004662 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 1162668004663 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1162668004664 TPP-binding site; other site 1162668004665 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1162668004666 PYR/PP interface [polypeptide binding]; other site 1162668004667 dimer interface [polypeptide binding]; other site 1162668004668 TPP binding site [chemical binding]; other site 1162668004669 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1162668004670 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1162668004671 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1162668004672 substrate binding pocket [chemical binding]; other site 1162668004673 chain length determination region; other site 1162668004674 substrate-Mg2+ binding site; other site 1162668004675 catalytic residues [active] 1162668004676 aspartate-rich region 1; other site 1162668004677 active site lid residues [active] 1162668004678 aspartate-rich region 2; other site 1162668004679 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 1162668004680 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 1162668004681 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1162668004682 generic binding surface II; other site 1162668004683 generic binding surface I; other site 1162668004684 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 1162668004685 putative active site [active] 1162668004686 metal binding site [ion binding]; metal-binding site 1162668004687 homodimer binding site [polypeptide binding]; other site 1162668004688 ribonuclease Y; Region: RNase_Y; TIGR03319 1162668004689 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1162668004690 Zn2+ binding site [ion binding]; other site 1162668004691 Mg2+ binding site [ion binding]; other site 1162668004692 recombination factor protein RarA; Reviewed; Region: PRK13342 1162668004693 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1162668004694 Walker A motif; other site 1162668004695 ATP binding site [chemical binding]; other site 1162668004696 Walker B motif; other site 1162668004697 arginine finger; other site 1162668004698 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1162668004699 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1162668004700 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1162668004701 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1162668004702 catalytic residue [active] 1162668004703 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 1162668004704 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 1162668004705 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1162668004706 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 1162668004707 S-adenosylmethionine binding site [chemical binding]; other site 1162668004708 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1162668004709 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1162668004710 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1162668004711 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1162668004712 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1162668004713 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 1162668004714 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 1162668004715 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 1162668004716 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1162668004717 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1162668004718 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1162668004719 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1162668004720 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1162668004721 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 1162668004722 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 1162668004723 4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557 1162668004724 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1162668004725 HI0933-like protein; Region: HI0933_like; pfam03486 1162668004726 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1162668004727 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1162668004728 putative active site [active] 1162668004729 putative metal binding site [ion binding]; other site 1162668004730 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 1162668004731 mce related protein; Region: MCE; pfam02470 1162668004732 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 1162668004733 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1162668004734 Walker A/P-loop; other site 1162668004735 ATP binding site [chemical binding]; other site 1162668004736 Q-loop/lid; other site 1162668004737 ABC transporter signature motif; other site 1162668004738 Walker B; other site 1162668004739 D-loop; other site 1162668004740 H-loop/switch region; other site 1162668004741 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1162668004742 Permease; Region: Permease; pfam02405 1162668004743 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 1162668004744 endonuclease IV; Provisional; Region: PRK01060 1162668004745 AP (apurinic/apyrimidinic) site pocket; other site 1162668004746 DNA interaction; other site 1162668004747 Metal-binding active site; metal-binding site 1162668004748 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cl01482 1162668004749 dimer interface [polypeptide binding]; other site 1162668004750 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1162668004751 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1162668004752 dimer interface [polypeptide binding]; other site 1162668004753 phosphorylation site [posttranslational modification] 1162668004754 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1162668004755 ATP binding site [chemical binding]; other site 1162668004756 Mg2+ binding site [ion binding]; other site 1162668004757 G-X-G motif; other site 1162668004758 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1162668004759 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1162668004760 active site 1162668004761 phosphorylation site [posttranslational modification] 1162668004762 intermolecular recognition site; other site 1162668004763 dimerization interface [polypeptide binding]; other site 1162668004764 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1162668004765 DNA binding site [nucleotide binding] 1162668004766 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 1162668004767 MPN+ (JAMM) motif; other site 1162668004768 Zinc-binding site [ion binding]; other site 1162668004769 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 1162668004770 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1162668004771 ATP binding site [chemical binding]; other site 1162668004772 substrate interface [chemical binding]; other site 1162668004773 NIL domain; Region: NIL; pfam09383 1162668004774 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1162668004775 MoaE interaction surface [polypeptide binding]; other site 1162668004776 MoeB interaction surface [polypeptide binding]; other site 1162668004777 thiocarboxylated glycine; other site 1162668004778 threonine synthase; Validated; Region: PRK07591 1162668004779 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 1162668004780 homodimer interface [polypeptide binding]; other site 1162668004781 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1162668004782 catalytic residue [active] 1162668004783 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 1162668004784 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1162668004785 ATP binding site [chemical binding]; other site 1162668004786 substrate interface [chemical binding]; other site 1162668004787 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1162668004788 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1162668004789 dimer interface [polypeptide binding]; other site 1162668004790 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1162668004791 catalytic residue [active] 1162668004792 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 1162668004793 thiS-thiF/thiG interaction site; other site 1162668004794 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 1162668004795 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 1162668004796 homotetramer interface [polypeptide binding]; other site 1162668004797 ligand binding site [chemical binding]; other site 1162668004798 catalytic site [active] 1162668004799 NAD binding site [chemical binding]; other site 1162668004800 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1162668004801 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1162668004802 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1162668004803 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1162668004804 isocitrate dehydrogenase; Validated; Region: PRK07362 1162668004805 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 1162668004806 plasma-membrane proton-efflux P-type ATPase; Region: ATPase-IIIA_H; TIGR01647 1162668004807 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1162668004808 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1162668004809 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1162668004810 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 1162668004811 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1162668004812 FeS/SAM binding site; other site 1162668004813 HemN C-terminal domain; Region: HemN_C; pfam06969 1162668004814 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 1162668004815 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 1162668004816 substrate binding site [chemical binding]; other site 1162668004817 active site 1162668004818 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 1162668004819 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 1162668004820 putative active site [active] 1162668004821 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 1162668004822 putative active site [active] 1162668004823 Winged helix-turn helix; Region: HTH_29; pfam13551 1162668004824 Homeodomain-like domain; Region: HTH_23; pfam13384 1162668004825 Integrase core domain; Region: rve; pfam00665 1162668004826 Protein of unknown function (DUF422); Region: DUF422; cl00991 1162668004827 Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411 1162668004828 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1162668004829 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1162668004830 Probable transposase; Region: OrfB_IS605; pfam01385 1162668004831 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1162668004832 Transposase IS200 like; Region: Y1_Tnp; pfam01797 1162668004833 EamA-like transporter family; Region: EamA; cl17759 1162668004834 hopanoid biosynthesis associated radical SAM protein HpnJ; Region: HpnJ; TIGR03471 1162668004835 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 1162668004836 B12 binding site [chemical binding]; other site 1162668004837 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1162668004838 FeS/SAM binding site; other site 1162668004839 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 1162668004840 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 1162668004841 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 1162668004842 uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228 1162668004843 putative NADP binding site [chemical binding]; other site 1162668004844 putative substrate binding site [chemical binding]; other site 1162668004845 active site 1162668004846 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 1162668004847 Surface antigen; Region: Bac_surface_Ag; pfam01103 1162668004848 squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507 1162668004849 Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892 1162668004850 Active site cavity [active] 1162668004851 catalytic acid [active] 1162668004852 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1162668004853 TPR motif; other site 1162668004854 binding surface 1162668004855 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 1162668004856 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 1162668004857 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1162668004858 HlyD family secretion protein; Region: HlyD_3; pfam13437 1162668004859 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1162668004860 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1162668004861 Walker A/P-loop; other site 1162668004862 ATP binding site [chemical binding]; other site 1162668004863 Q-loop/lid; other site 1162668004864 ABC transporter signature motif; other site 1162668004865 Walker B; other site 1162668004866 D-loop; other site 1162668004867 H-loop/switch region; other site 1162668004868 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1162668004869 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1162668004870 Walker A/P-loop; other site 1162668004871 ATP binding site [chemical binding]; other site 1162668004872 Q-loop/lid; other site 1162668004873 ABC transporter signature motif; other site 1162668004874 Walker B; other site 1162668004875 D-loop; other site 1162668004876 H-loop/switch region; other site 1162668004877 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1162668004878 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 1162668004879 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1162668004880 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1162668004881 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1162668004882 Cytochrome c; Region: Cytochrom_C; cl11414 1162668004883 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 1162668004884 putative active site [active] 1162668004885 transaldolase; Provisional; Region: PRK03903 1162668004886 catalytic residue [active] 1162668004887 putative phosphoketolase; Provisional; Region: PRK05261 1162668004888 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 1162668004889 TPP-binding site; other site 1162668004890 XFP C-terminal domain; Region: XFP_C; pfam09363 1162668004891 dihydrolipoamide dehydrogenase; Validated; Region: PRK06292 1162668004892 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1162668004893 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1162668004894 Uncharacterized ACR, YggU family COG1872; Region: DUF167; pfam02594 1162668004895 DivIVA protein; Region: DivIVA; pfam05103 1162668004896 DivIVA domain; Region: DivI1A_domain; TIGR03544 1162668004897 YGGT family; Region: YGGT; pfam02325 1162668004898 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 1162668004899 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1162668004900 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1162668004901 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1162668004902 catalytic residue [active] 1162668004903 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 1162668004904 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 1162668004905 cell division protein FtsZ; Validated; Region: PRK09330 1162668004906 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1162668004907 nucleotide binding site [chemical binding]; other site 1162668004908 SulA interaction site; other site 1162668004909 cell division protein FtsA; Region: ftsA; TIGR01174 1162668004910 Cell division protein FtsA; Region: FtsA; smart00842 1162668004911 Cell division protein FtsA; Region: FtsA; pfam14450 1162668004912 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 1162668004913 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1162668004914 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1162668004915 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 1162668004916 FAD binding domain; Region: FAD_binding_4; pfam01565 1162668004917 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1162668004918 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1162668004919 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1162668004920 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1162668004921 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1162668004922 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1162668004923 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 1162668004924 homodimer interface [polypeptide binding]; other site 1162668004925 active site 1162668004926 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 1162668004927 UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell envelope biogenesis, outer membrane]; Region: MurD; COG0771 1162668004928 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1162668004929 NAD binding site [chemical binding]; other site 1162668004930 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1162668004931 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1162668004932 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1162668004933 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1162668004934 Mg++ binding site [ion binding]; other site 1162668004935 putative catalytic motif [active] 1162668004936 putative substrate binding site [chemical binding]; other site 1162668004937 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 1162668004938 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1162668004939 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1162668004940 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1162668004941 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 1162668004942 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1162668004943 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1162668004944 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1162668004945 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1162668004946 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1162668004947 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1162668004948 MraW methylase family; Region: Methyltransf_5; cl17771 1162668004949 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 1162668004950 MraZ protein; Region: MraZ; pfam02381 1162668004951 cell division protein MraZ; Reviewed; Region: PRK00326 1162668004952 MraZ protein; Region: MraZ; pfam02381 1162668004953 Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018 1162668004954 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1162668004955 dimer interface [polypeptide binding]; other site 1162668004956 catalytic triad [active] 1162668004957 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 1162668004958 CoA binding domain; Region: CoA_binding; smart00881 1162668004959 CoA-ligase; Region: Ligase_CoA; pfam00549 1162668004960 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 1162668004961 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 1162668004962 CoA-ligase; Region: Ligase_CoA; pfam00549 1162668004963 FAD binding domain; Region: FAD_binding_2; pfam00890 1162668004964 L-aspartate oxidase; Provisional; Region: PRK06175 1162668004965 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1162668004966 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 1162668004967 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 1162668004968 Citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CCL cleaves citryl-CoA (CiCoA) to acetyl-CoA (AcCoA) and oxaloacetate (OAA); Region: CCL_ACL-C; cd06100 1162668004969 active site 1162668004970 oxalacetate binding site [chemical binding]; other site 1162668004971 citrylCoA binding site [chemical binding]; other site 1162668004972 coenzyme A binding site [chemical binding]; other site 1162668004973 catalytic triad [active] 1162668004974 aconitate hydratase; Validated; Region: PRK07229 1162668004975 Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: AcnA_Bact; cd01585 1162668004976 substrate binding site [chemical binding]; other site 1162668004977 ligand binding site [chemical binding]; other site 1162668004978 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 1162668004979 substrate binding site [chemical binding]; other site 1162668004980 Succinyl-CoA synthetase, alpha subunit [Energy production and conversion]; Region: SucD; COG0074 1162668004981 CoA binding domain; Region: CoA_binding; smart00881 1162668004982 CoA-ligase; Region: Ligase_CoA; pfam00549 1162668004983 Succinyl-CoA synthetase, beta subunit [Energy production and conversion]; Region: SucC; COG0045 1162668004984 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 1162668004985 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1162668004986 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1162668004987 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1162668004988 S-adenosylmethionine binding site [chemical binding]; other site 1162668004989 polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709 1162668004990 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1162668004991 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1162668004992 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1162668004993 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1162668004994 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 1162668004995 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 1162668004996 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 1162668004997 putative homodimer interface [polypeptide binding]; other site 1162668004998 putative active site pocket [active] 1162668004999 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 1162668005000 phosphoglucomutase; Validated; Region: PRK07564 1162668005001 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 1162668005002 active site 1162668005003 substrate binding site [chemical binding]; other site 1162668005004 metal binding site [ion binding]; metal-binding site 1162668005005 Domain of unknown function (DUF4398); Region: DUF4398; pfam14346 1162668005006 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1162668005007 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1162668005008 ligand binding site [chemical binding]; other site 1162668005009 Domain of unknown function (DUF4398); Region: DUF4398; pfam14346 1162668005010 Acetokinase family; Region: Acetate_kinase; cl17229 1162668005011 propionate/acetate kinase; Provisional; Region: PRK12379 1162668005012 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 1162668005013 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1162668005014 Sel1-like repeats; Region: SEL1; smart00671 1162668005015 Sel1 repeat; Region: Sel1; cl02723 1162668005016 Sel1-like repeats; Region: SEL1; smart00671 1162668005017 Sel1-like repeats; Region: SEL1; smart00671 1162668005018 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1162668005019 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 1162668005020 putative NAD(P) binding site [chemical binding]; other site 1162668005021 putative substrate binding site [chemical binding]; other site 1162668005022 catalytic Zn binding site [ion binding]; other site 1162668005023 structural Zn binding site [ion binding]; other site 1162668005024 dimer interface [polypeptide binding]; other site 1162668005025 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 1162668005026 ATP-sulfurylase; Region: ATPS; cd00517 1162668005027 active site 1162668005028 HXXH motif; other site 1162668005029 flexible loop; other site 1162668005030 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 1162668005031 adenylylsulfate reductase subunit alpha; Validated; Region: PRK06854 1162668005032 L-aspartate oxidase; Provisional; Region: PRK06175 1162668005033 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1162668005034 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 1162668005035 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 1162668005036 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1162668005037 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 1162668005038 Walker A motif; other site 1162668005039 ATP binding site [chemical binding]; other site 1162668005040 Walker B motif; other site 1162668005041 arginine finger; other site 1162668005042 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1162668005043 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 1162668005044 AAA domain; Region: AAA_26; pfam13500 1162668005045 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 1162668005046 PAS domain; Region: PAS_9; pfam13426 1162668005047 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1162668005048 putative active site [active] 1162668005049 heme pocket [chemical binding]; other site 1162668005050 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1162668005051 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1162668005052 dimer interface [polypeptide binding]; other site 1162668005053 putative CheW interface [polypeptide binding]; other site 1162668005054 GAF domain; Region: GAF_3; pfam13492 1162668005055 GAF domain; Region: GAF_2; pfam13185 1162668005056 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1162668005057 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1162668005058 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1162668005059 GAF domain; Region: GAF_3; pfam13492 1162668005060 PAS fold; Region: PAS_4; pfam08448 1162668005061 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1162668005062 putative active site [active] 1162668005063 heme pocket [chemical binding]; other site 1162668005064 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1162668005065 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1162668005066 metal binding site [ion binding]; metal-binding site 1162668005067 active site 1162668005068 I-site; other site 1162668005069 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1162668005070 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3002 1162668005071 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 1162668005072 NADH dehydrogenase subunit L; Provisional; Region: PRK08168 1162668005073 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 1162668005074 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1162668005075 Uncharacterized conserved protein (DUF2294); Region: DUF2294; pfam10057 1162668005076 Uncharacterized conserved protein (DUF2294); Region: DUF2294; pfam10057 1162668005077 HD domain; Region: HD_5; pfam13487 1162668005078 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 1162668005079 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1162668005080 Zn2+ binding site [ion binding]; other site 1162668005081 Mg2+ binding site [ion binding]; other site 1162668005082 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 1162668005083 active site clefts [active] 1162668005084 zinc binding site [ion binding]; other site 1162668005085 dimer interface [polypeptide binding]; other site 1162668005086 Domain of unknown function (DUF4384); Region: DUF4384; pfam14326 1162668005087 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1162668005088 Domain of unknown function DUF21; Region: DUF21; pfam01595 1162668005089 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1162668005090 Transporter associated domain; Region: CorC_HlyC; smart01091 1162668005091 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1162668005092 PLD-like domain; Region: PLDc_2; pfam13091 1162668005093 Rrf2 family protein; Region: rrf2_super; TIGR00738 1162668005094 Transcriptional regulator; Region: Rrf2; pfam02082 1162668005095 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1162668005096 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1162668005097 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1162668005098 catalytic residue [active] 1162668005099 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1162668005100 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1162668005101 trimerization site [polypeptide binding]; other site 1162668005102 active site 1162668005103 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 1162668005104 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1162668005105 HSP70 interaction site [polypeptide binding]; other site 1162668005106 chaperone protein HscA; Provisional; Region: hscA; PRK05183 1162668005107 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 1162668005108 nucleotide binding site [chemical binding]; other site 1162668005109 putative NEF/HSP70 interaction site [polypeptide binding]; other site 1162668005110 SBD interface [polypeptide binding]; other site 1162668005111 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1162668005112 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1162668005113 catalytic loop [active] 1162668005114 iron binding site [ion binding]; other site 1162668005115 Iron-sulphur cluster assembly; Region: Fe-S_assembly; pfam04384 1162668005116 Domain of unknown function DUF59; Region: DUF59; pfam01883 1162668005117 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 1162668005118 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1162668005119 Walker A motif; other site 1162668005120 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 1162668005121 active site 1162668005122 8-oxo-dGMP binding site [chemical binding]; other site 1162668005123 nudix motif; other site 1162668005124 metal binding site [ion binding]; metal-binding site 1162668005125 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1162668005126 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1162668005127 dimerization interface 3.5A [polypeptide binding]; other site 1162668005128 active site 1162668005129 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 1162668005130 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 1162668005131 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1162668005132 dimer interface [polypeptide binding]; other site 1162668005133 putative CheW interface [polypeptide binding]; other site 1162668005134 Protein of unknown function (DUF971); Region: DUF971; pfam06155 1162668005135 NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767 1162668005136 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1162668005137 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1162668005138 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1162668005139 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1162668005140 seryl-tRNA synthetase; Provisional; Region: PRK05431 1162668005141 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1162668005142 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1162668005143 dimer interface [polypeptide binding]; other site 1162668005144 active site 1162668005145 motif 1; other site 1162668005146 motif 2; other site 1162668005147 motif 3; other site 1162668005148 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1162668005149 TPR motif; other site 1162668005150 binding surface 1162668005151 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 1162668005152 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1162668005153 HflX GTPase family; Region: HflX; cd01878 1162668005154 G1 box; other site 1162668005155 GTP/Mg2+ binding site [chemical binding]; other site 1162668005156 Switch I region; other site 1162668005157 G2 box; other site 1162668005158 G3 box; other site 1162668005159 Switch II region; other site 1162668005160 G4 box; other site 1162668005161 G5 box; other site 1162668005162 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1162668005163 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1162668005164 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1162668005165 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1162668005166 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1162668005167 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1162668005168 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1162668005169 PAS domain; Region: PAS_9; pfam13426 1162668005170 putative active site [active] 1162668005171 heme pocket [chemical binding]; other site 1162668005172 PAS domain S-box; Region: sensory_box; TIGR00229 1162668005173 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1162668005174 putative active site [active] 1162668005175 heme pocket [chemical binding]; other site 1162668005176 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1162668005177 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1162668005178 metal binding site [ion binding]; metal-binding site 1162668005179 active site 1162668005180 I-site; other site 1162668005181 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1162668005182 Septum formation initiator; Region: DivIC; cl17659 1162668005183 enolase; Provisional; Region: eno; PRK00077 1162668005184 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1162668005185 dimer interface [polypeptide binding]; other site 1162668005186 metal binding site [ion binding]; metal-binding site 1162668005187 substrate binding pocket [chemical binding]; other site 1162668005188 cytochrome c nitrate reductase, small subunit; Region: cytochr_NrfH; TIGR03153 1162668005189 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 1162668005190 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 1162668005191 GatB domain; Region: GatB_Yqey; smart00845 1162668005192 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1162668005193 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 1162668005194 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 1162668005195 tetramerization interface [polypeptide binding]; other site 1162668005196 active site 1162668005197 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 1162668005198 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 1162668005199 Part of AAA domain; Region: AAA_19; pfam13245 1162668005200 The Sema domain, a protein interacting module, of semaphorins and plexins; Region: Sema; cl15693 1162668005201 Family description; Region: UvrD_C_2; pfam13538 1162668005202 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 1162668005203 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 1162668005204 N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) [Cell envelope biogenesis, outer membrane]; Region: GlmU; COG1207 1162668005205 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1162668005206 active site 1162668005207 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1162668005208 active site 1162668005209 substrate binding site [chemical binding]; other site 1162668005210 CoA binding site [chemical binding]; other site 1162668005211 Protein of unknown function (DUF502); Region: DUF502; cl01107 1162668005212 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cd00322 1162668005213 FAD binding pocket [chemical binding]; other site 1162668005214 conserved FAD binding motif [chemical binding]; other site 1162668005215 phosphate binding motif [ion binding]; other site 1162668005216 beta-alpha-beta structure motif; other site 1162668005217 NAD binding pocket [chemical binding]; other site 1162668005218 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 1162668005219 Protein of unknown function, DUF488; Region: DUF488; cl01246 1162668005220 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 1162668005221 homotetramer interface [polypeptide binding]; other site 1162668005222 active site 1162668005223 FMN binding site [chemical binding]; other site 1162668005224 substrate binding site [chemical binding]; other site 1162668005225 catalytic residue [active] 1162668005226 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 1162668005227 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 1162668005228 Predicted membrane protein [Function unknown]; Region: COG2259 1162668005229 MarR family; Region: MarR_2; pfam12802 1162668005230 thymidylate kinase; Validated; Region: tmk; PRK00698 1162668005231 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1162668005232 TMP-binding site; other site 1162668005233 ATP-binding site [chemical binding]; other site 1162668005234 DNA polymerase III, delta' subunit; Region: holB; TIGR00678 1162668005235 DNA polymerase III subunit delta'; Validated; Region: PRK08485 1162668005236 ATPase involved in DNA replication [DNA replication, recombination, and repair]; Region: HolB; COG0470 1162668005237 PSP1 C-terminal conserved region; Region: PSP1; pfam04468 1162668005238 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 1162668005239 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1162668005240 active site 1162668005241 HIGH motif; other site 1162668005242 KMSKS motif; other site 1162668005243 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1162668005244 anticodon binding site; other site 1162668005245 tRNA binding surface [nucleotide binding]; other site 1162668005246 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 1162668005247 dimer interface [polypeptide binding]; other site 1162668005248 putative tRNA-binding site [nucleotide binding]; other site 1162668005249 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 1162668005250 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1162668005251 active site 1162668005252 YacP-like NYN domain; Region: NYN_YacP; cl01491 1162668005253 amino acid transporter; Region: 2A0306; TIGR00909 1162668005254 hypothetical protein; Provisional; Region: PHA02764 1162668005255 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1162668005256 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1162668005257 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1162668005258 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1162668005259 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1162668005260 Na binding site [ion binding]; other site 1162668005261 GTP-binding protein Der; Reviewed; Region: PRK00093 1162668005262 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1162668005263 G1 box; other site 1162668005264 GTP/Mg2+ binding site [chemical binding]; other site 1162668005265 Switch I region; other site 1162668005266 G2 box; other site 1162668005267 Switch II region; other site 1162668005268 G3 box; other site 1162668005269 G4 box; other site 1162668005270 G5 box; other site 1162668005271 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1162668005272 G1 box; other site 1162668005273 GTP/Mg2+ binding site [chemical binding]; other site 1162668005274 Switch I region; other site 1162668005275 G2 box; other site 1162668005276 G3 box; other site 1162668005277 Switch II region; other site 1162668005278 G4 box; other site 1162668005279 G5 box; other site 1162668005280 phosphoenolpyruvate synthase; Validated; Region: PRK06464 1162668005281 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1162668005282 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1162668005283 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1162668005284 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 1162668005285 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1162668005286 Walker A motif; other site 1162668005287 ATP binding site [chemical binding]; other site 1162668005288 Walker B motif; other site 1162668005289 arginine finger; other site 1162668005290 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 1162668005291 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 1162668005292 putative active site [active] 1162668005293 putative metal binding site [ion binding]; other site 1162668005294 diacylglycerol glucosyltransferase; Provisional; Region: PRK13609 1162668005295 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 1162668005296 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1162668005297 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1162668005298 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1162668005299 putative substrate translocation pore; other site 1162668005300 PQQ enzyme repeat; Region: PQQ; pfam01011 1162668005301 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 1162668005302 PQQ-like domain; Region: PQQ_2; pfam13360 1162668005303 Trp docking motif [polypeptide binding]; other site 1162668005304 active site 1162668005305 Domain of unknown function (DUF4277); Region: DUF4277; pfam14104 1162668005306 Transposase [DNA replication, recombination, and repair]; Region: COG5421 1162668005307 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 1162668005308 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1162668005309 active site 1162668005310 substrate binding site [chemical binding]; other site 1162668005311 cosubstrate binding site; other site 1162668005312 catalytic site [active] 1162668005313 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1162668005314 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1162668005315 dimerization interface [polypeptide binding]; other site 1162668005316 putative ATP binding site [chemical binding]; other site 1162668005317 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1162668005318 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1162668005319 Coenzyme A binding pocket [chemical binding]; other site 1162668005320 ribonuclease III; Reviewed; Region: rnc; PRK00102 1162668005321 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1162668005322 dimerization interface [polypeptide binding]; other site 1162668005323 active site 1162668005324 metal binding site [ion binding]; metal-binding site 1162668005325 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1162668005326 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 1162668005327 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1162668005328 dimer interface [polypeptide binding]; other site 1162668005329 active site 1162668005330 acyl carrier protein; Provisional; Region: acpP; PRK00982 1162668005331 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1162668005332 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 1162668005333 NAD(P) binding site [chemical binding]; other site 1162668005334 homotetramer interface [polypeptide binding]; other site 1162668005335 homodimer interface [polypeptide binding]; other site 1162668005336 active site 1162668005337 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1162668005338 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1162668005339 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 1162668005340 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1162668005341 dimer interface [polypeptide binding]; other site 1162668005342 active site 1162668005343 CoA binding pocket [chemical binding]; other site 1162668005344 putative phosphate acyltransferase; Provisional; Region: PRK05331 1162668005345 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 1162668005346 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 1162668005347 prolyl-tRNA synthetase; Provisional; Region: PRK12325 1162668005348 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 1162668005349 dimer interface [polypeptide binding]; other site 1162668005350 motif 1; other site 1162668005351 active site 1162668005352 motif 2; other site 1162668005353 motif 3; other site 1162668005354 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1162668005355 anticodon binding site; other site 1162668005356 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 1162668005357 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1162668005358 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1162668005359 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 1162668005360 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1162668005361 active site 1162668005362 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1162668005363 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1162668005364 putative substrate binding region [chemical binding]; other site 1162668005365 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 1162668005366 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 1162668005367 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 1162668005368 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 1162668005369 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 1162668005370 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1162668005371 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 1162668005372 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 1162668005373 catalytic residue [active] 1162668005374 putative FPP diphosphate binding site; other site 1162668005375 putative FPP binding hydrophobic cleft; other site 1162668005376 dimer interface [polypeptide binding]; other site 1162668005377 putative IPP diphosphate binding site; other site 1162668005378 translocation protein TolB; Provisional; Region: tolB; PRK05137 1162668005379 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 1162668005380 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 1162668005381 Potassium binding sites [ion binding]; other site 1162668005382 Cesium cation binding sites [ion binding]; other site 1162668005383 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 1162668005384 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1162668005385 Coenzyme A binding pocket [chemical binding]; other site 1162668005386 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 1162668005387 Glycoprotease family; Region: Peptidase_M22; pfam00814 1162668005388 DNA repair protein RadA; Provisional; Region: PRK11823 1162668005389 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1162668005390 Walker A motif; other site 1162668005391 ATP binding site [chemical binding]; other site 1162668005392 Walker B motif; other site 1162668005393 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1162668005394 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 1162668005395 peptidase PmbA; Provisional; Region: PRK11040 1162668005396 protease TldD; Provisional; Region: tldD; PRK10735 1162668005397 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1162668005398 Beta-lactamase; Region: Beta-lactamase; pfam00144 1162668005399 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 1162668005400 active site lid residues [active] 1162668005401 substrate binding pocket [chemical binding]; other site 1162668005402 catalytic residues [active] 1162668005403 substrate-Mg2+ binding site; other site 1162668005404 aspartate-rich region 1; other site 1162668005405 aspartate-rich region 2; other site 1162668005406 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1162668005407 squalene-associated FAD-dependent desaturase; Region: HpnE; TIGR03467 1162668005408 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 1162668005409 active site lid residues [active] 1162668005410 substrate binding pocket [chemical binding]; other site 1162668005411 catalytic residues [active] 1162668005412 substrate-Mg2+ binding site; other site 1162668005413 aspartate-rich region 1; other site 1162668005414 aspartate-rich region 2; other site 1162668005415 Creatinine amidohydrolase; Region: Creatininase; pfam02633 1162668005416 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 1162668005417 dimer interface [polypeptide binding]; other site 1162668005418 catalytic triad [active] 1162668005419 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 1162668005420 Eukaryotic phosphomannomutase; Region: PMM; cl17107 1162668005421 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1162668005422 motif II; other site 1162668005423 Outer membrane lipoprotein Slp family; Region: Slp; cl01164 1162668005424 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330 1162668005425 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 1162668005426 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 1162668005427 Predicted glycosyl transferase [General function prediction only]; Region: COG4671 1162668005428 Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369 1162668005429 Integrase core domain; Region: rve; pfam00665 1162668005430 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1162668005431 Transposase; Region: HTH_Tnp_1; pfam01527 1162668005432 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1162668005433 non-specific DNA binding site [nucleotide binding]; other site 1162668005434 sequence-specific DNA binding site [nucleotide binding]; other site 1162668005435 salt bridge; other site 1162668005436 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 1162668005437 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1162668005438 MULE transposase domain; Region: MULE; pfam10551 1162668005439 PEP-CTERM motif; Region: VPEP; pfam07589 1162668005440 Pirin-related protein [General function prediction only]; Region: COG1741 1162668005441 Pirin; Region: Pirin; pfam02678 1162668005442 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1162668005443 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1162668005444 putative substrate translocation pore; other site 1162668005445 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1162668005446 putative substrate translocation pore; other site 1162668005447 HDOD domain; Region: HDOD; pfam08668 1162668005448 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1162668005449 Zn2+ binding site [ion binding]; other site 1162668005450 Mg2+ binding site [ion binding]; other site 1162668005451 GAF domain; Region: GAF_2; pfam13185 1162668005452 PAS domain S-box; Region: sensory_box; TIGR00229 1162668005453 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1162668005454 PAS domain; Region: PAS_9; pfam13426 1162668005455 putative active site [active] 1162668005456 heme pocket [chemical binding]; other site 1162668005457 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1162668005458 PAS domain; Region: PAS_9; pfam13426 1162668005459 putative active site [active] 1162668005460 heme pocket [chemical binding]; other site 1162668005461 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1162668005462 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1162668005463 metal binding site [ion binding]; metal-binding site 1162668005464 active site 1162668005465 I-site; other site 1162668005466 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1162668005467 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1162668005468 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1162668005469 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1162668005470 Cytochrome c; Region: Cytochrom_C; cl11414 1162668005471 Cytochrome c; Region: Cytochrom_C; cl11414 1162668005472 Cytochrome c [Energy production and conversion]; Region: COG3258 1162668005473 Cytochrome c; Region: Cytochrom_C; pfam00034 1162668005474 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1162668005475 catalytic core [active] 1162668005476 Protein of unknown function (DUF989); Region: DUF989; pfam06181 1162668005477 helicase 45; Provisional; Region: PTZ00424 1162668005478 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1162668005479 ATP binding site [chemical binding]; other site 1162668005480 Mg++ binding site [ion binding]; other site 1162668005481 motif III; other site 1162668005482 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1162668005483 nucleotide binding region [chemical binding]; other site 1162668005484 ATP-binding site [chemical binding]; other site 1162668005485 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 1162668005486 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 1162668005487 catalytic triad [active] 1162668005488 glutamate racemase; Provisional; Region: PRK00865 1162668005489 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 1162668005490 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1162668005491 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1162668005492 active site 1162668005493 dimerization interface [polypeptide binding]; other site 1162668005494 ribonuclease PH; Reviewed; Region: rph; PRK00173 1162668005495 Ribonuclease PH; Region: RNase_PH_bact; cd11362 1162668005496 hexamer interface [polypeptide binding]; other site 1162668005497 active site 1162668005498 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1162668005499 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1162668005500 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1162668005501 ABC transporter; Region: ABC_tran_2; pfam12848 1162668005502 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1162668005503 Predicted phosphohydrolase (DHH superfamily) [General function prediction only]; Region: COG2404 1162668005504 DHHA1 domain; Region: DHHA1; pfam02272 1162668005505 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1162668005506 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1162668005507 putative dimer interface [polypeptide binding]; other site 1162668005508 16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839 1162668005509 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 1162668005510 active site 1162668005511 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1162668005512 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1162668005513 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1162668005514 catalytic residue [active] 1162668005515 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 1162668005516 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1162668005517 Zn2+ binding site [ion binding]; other site 1162668005518 Mg2+ binding site [ion binding]; other site 1162668005519 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 1162668005520 RNA/DNA hybrid binding site [nucleotide binding]; other site 1162668005521 active site 1162668005522 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 1162668005523 Putative zinc ribbon domain; Region: DUF164; pfam02591 1162668005524 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 1162668005525 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 1162668005526 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1162668005527 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1162668005528 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1162668005529 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1162668005530 DNA binding residues [nucleotide binding] 1162668005531 DNA primase, catalytic core; Region: dnaG; TIGR01391 1162668005532 CHC2 zinc finger; Region: zf-CHC2; cl17510 1162668005533 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1162668005534 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1162668005535 active site 1162668005536 metal binding site [ion binding]; metal-binding site 1162668005537 interdomain interaction site; other site 1162668005538 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 1162668005539 Yqey-like protein; Region: YqeY; pfam09424 1162668005540 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 1162668005541 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1162668005542 IHF dimer interface [polypeptide binding]; other site 1162668005543 IHF - DNA interface [nucleotide binding]; other site 1162668005544 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 1162668005545 nucleotide binding site/active site [active] 1162668005546 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 1162668005547 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 1162668005548 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 1162668005549 metal binding site [ion binding]; metal-binding site 1162668005550 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1162668005551 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1162668005552 substrate binding site [chemical binding]; other site 1162668005553 glutamase interaction surface [polypeptide binding]; other site 1162668005554 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1162668005555 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 1162668005556 catalytic residues [active] 1162668005557 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 1162668005558 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1162668005559 putative active site [active] 1162668005560 oxyanion strand; other site 1162668005561 catalytic triad [active] 1162668005562 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 1162668005563 putative active site pocket [active] 1162668005564 4-fold oligomerization interface [polypeptide binding]; other site 1162668005565 metal binding residues [ion binding]; metal-binding site 1162668005566 3-fold/trimer interface [polypeptide binding]; other site 1162668005567 histidinol-phosphate aminotransferase; Provisional; Region: PRK04870 1162668005568 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1162668005569 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1162668005570 homodimer interface [polypeptide binding]; other site 1162668005571 catalytic residue [active] 1162668005572 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1162668005573 histidinol dehydrogenase; Region: hisD; TIGR00069 1162668005574 NAD binding site [chemical binding]; other site 1162668005575 dimerization interface [polypeptide binding]; other site 1162668005576 product binding site; other site 1162668005577 substrate binding site [chemical binding]; other site 1162668005578 zinc binding site [ion binding]; other site 1162668005579 catalytic residues [active] 1162668005580 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 1162668005581 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 1162668005582 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1162668005583 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1162668005584 hinge; other site 1162668005585 active site 1162668005586 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 1162668005587 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1162668005588 S-adenosylmethionine binding site [chemical binding]; other site 1162668005589 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1162668005590 PCRF domain; Region: PCRF; pfam03462 1162668005591 RF-1 domain; Region: RF-1; pfam00472 1162668005592 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 1162668005593 transcription termination factor Rho; Provisional; Region: rho; PRK09376 1162668005594 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 1162668005595 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 1162668005596 RNA binding site [nucleotide binding]; other site 1162668005597 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 1162668005598 multimer interface [polypeptide binding]; other site 1162668005599 Walker A motif; other site 1162668005600 ATP binding site [chemical binding]; other site 1162668005601 Walker B motif; other site 1162668005602 Cytochrome c; Region: Cytochrom_C; cl11414 1162668005603 Transposase IS200 like; Region: Y1_Tnp; pfam01797 1162668005604 Probable transposase; Region: OrfB_IS605; pfam01385 1162668005605 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1162668005606 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 1162668005607 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 1162668005608 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_2; cd11599 1162668005609 putative active site [active] 1162668005610 Zn binding site [ion binding]; other site 1162668005611 fructose-1,6-bisphosphatase; Provisional; Region: PRK09293 1162668005612 active site 1162668005613 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1162668005614 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1162668005615 NAD(P) binding site [chemical binding]; other site 1162668005616 catalytic residues [active] 1162668005617 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1162668005618 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1162668005619 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1162668005620 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1162668005621 metal binding site [ion binding]; metal-binding site 1162668005622 active site 1162668005623 I-site; other site 1162668005624 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 1162668005625 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1162668005626 Zn2+ binding site [ion binding]; other site 1162668005627 Mg2+ binding site [ion binding]; other site 1162668005628 Thymidylate synthase complementing protein; Region: Thy1; pfam02511 1162668005629 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 1162668005630 PhoU domain; Region: PhoU; pfam01895 1162668005631 PhoU domain; Region: PhoU; pfam01895 1162668005632 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 1162668005633 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1162668005634 Walker A/P-loop; other site 1162668005635 ATP binding site [chemical binding]; other site 1162668005636 Q-loop/lid; other site 1162668005637 ABC transporter signature motif; other site 1162668005638 Walker B; other site 1162668005639 D-loop; other site 1162668005640 H-loop/switch region; other site 1162668005641 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 1162668005642 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1162668005643 dimer interface [polypeptide binding]; other site 1162668005644 conserved gate region; other site 1162668005645 putative PBP binding loops; other site 1162668005646 ABC-ATPase subunit interface; other site 1162668005647 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 1162668005648 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1162668005649 dimer interface [polypeptide binding]; other site 1162668005650 conserved gate region; other site 1162668005651 putative PBP binding loops; other site 1162668005652 ABC-ATPase subunit interface; other site 1162668005653 PBP superfamily domain; Region: PBP_like_2; cl17296 1162668005654 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1162668005655 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1162668005656 active site 1162668005657 phosphorylation site [posttranslational modification] 1162668005658 intermolecular recognition site; other site 1162668005659 dimerization interface [polypeptide binding]; other site 1162668005660 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1162668005661 DNA binding site [nucleotide binding] 1162668005662 Domain of unknown function DUF77; Region: DUF77; pfam01910 1162668005663 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1162668005664 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1162668005665 GDP-binding site [chemical binding]; other site 1162668005666 ACT binding site; other site 1162668005667 IMP binding site; other site 1162668005668 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493 1162668005669 Protein of unknown function (DUF1054); Region: DUF1054; pfam06335 1162668005670 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 1162668005671 NADPH bind site [chemical binding]; other site 1162668005672 putative FMN binding site [chemical binding]; other site 1162668005673 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 1162668005674 putative FMN binding site [chemical binding]; other site 1162668005675 NADPH bind site [chemical binding]; other site 1162668005676 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 1162668005677 ABC1 family; Region: ABC1; pfam03109 1162668005678 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1162668005679 active site 1162668005680 ATP binding site [chemical binding]; other site 1162668005681 ABC1 family; Region: ABC1; cl17513 1162668005682 hypothetical protein; Reviewed; Region: PRK00024 1162668005683 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 1162668005684 helix-hairpin-helix signature motif; other site 1162668005685 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 1162668005686 MPN+ (JAMM) motif; other site 1162668005687 Zinc-binding site [ion binding]; other site 1162668005688 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1162668005689 PAS domain; Region: PAS_9; pfam13426 1162668005690 putative active site [active] 1162668005691 heme pocket [chemical binding]; other site 1162668005692 PAS domain S-box; Region: sensory_box; TIGR00229 1162668005693 PAS domain; Region: PAS_9; pfam13426 1162668005694 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1162668005695 PAS domain; Region: PAS_9; pfam13426 1162668005696 putative active site [active] 1162668005697 heme pocket [chemical binding]; other site 1162668005698 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1162668005699 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1162668005700 metal binding site [ion binding]; metal-binding site 1162668005701 active site 1162668005702 I-site; other site 1162668005703 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1162668005704 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 1162668005705 active site 1162668005706 Flagellin N-methylase; Region: FliB; pfam03692 1162668005707 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 1162668005708 PQQ-like domain; Region: PQQ_2; pfam13360 1162668005709 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 1162668005710 Trp docking motif [polypeptide binding]; other site 1162668005711 active site 1162668005712 SmpA / OmlA family; Region: SmpA_OmlA; cl17115 1162668005713 Transglycosylase; Region: Transgly; pfam00912 1162668005714 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1162668005715 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1162668005716 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 1162668005717 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 1162668005718 Winged helix-turn helix; Region: HTH_29; pfam13551 1162668005719 Homeodomain-like domain; Region: HTH_23; pfam13384 1162668005720 Integrase core domain; Region: rve; pfam00665 1162668005721 PAS fold; Region: PAS_4; pfam08448 1162668005722 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1162668005723 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1162668005724 dimer interface [polypeptide binding]; other site 1162668005725 putative CheW interface [polypeptide binding]; other site 1162668005726 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1162668005727 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1162668005728 HlyD family secretion protein; Region: HlyD_3; pfam13437 1162668005729 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1162668005730 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1162668005731 FtsX-like permease family; Region: FtsX; pfam02687 1162668005732 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1162668005733 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1162668005734 Walker A/P-loop; other site 1162668005735 ATP binding site [chemical binding]; other site 1162668005736 Q-loop/lid; other site 1162668005737 ABC transporter signature motif; other site 1162668005738 Walker B; other site 1162668005739 D-loop; other site 1162668005740 H-loop/switch region; other site 1162668005741 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 1162668005742 dimer interface [polypeptide binding]; other site 1162668005743 substrate binding site [chemical binding]; other site 1162668005744 metal binding sites [ion binding]; metal-binding site 1162668005745 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1162668005746 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1162668005747 putative active site [active] 1162668005748 heme pocket [chemical binding]; other site 1162668005749 PAS domain S-box; Region: sensory_box; TIGR00229 1162668005750 PAS domain; Region: PAS_8; pfam13188 1162668005751 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1162668005752 PAS domain; Region: PAS_9; pfam13426 1162668005753 putative active site [active] 1162668005754 heme pocket [chemical binding]; other site 1162668005755 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1162668005756 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1162668005757 metal binding site [ion binding]; metal-binding site 1162668005758 active site 1162668005759 I-site; other site 1162668005760 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 1162668005761 GAF domain; Region: GAF; pfam01590 1162668005762 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1162668005763 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1162668005764 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1162668005765 metal binding site [ion binding]; metal-binding site 1162668005766 active site 1162668005767 I-site; other site 1162668005768 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1162668005769 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1162668005770 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1162668005771 putative active site [active] 1162668005772 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 1162668005773 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 1162668005774 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1162668005775 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1162668005776 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1162668005777 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1162668005778 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1162668005779 Methyltransferase domain; Region: Methyltransf_12; pfam08242 1162668005780 TPR repeat; Region: TPR_11; pfam13414 1162668005781 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1162668005782 binding surface 1162668005783 TPR motif; other site 1162668005784 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1162668005785 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1162668005786 binding surface 1162668005787 TPR motif; other site 1162668005788 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1162668005789 DUF based on E. rectale Gene description (DUF3880); Region: DUF3880; pfam12996 1162668005790 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 1162668005791 Flagellar protein FliS; Region: FliS; cl00654 1162668005792 Flagellar capping protein [Cell motility and secretion]; Region: FliD; COG1345 1162668005793 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 1162668005794 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 1162668005795 flagellin; Provisional; Region: PRK12802 1162668005796 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1162668005797 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1162668005798 FliW protein; Region: FliW; cl00740 1162668005799 Global regulator protein family; Region: CsrA; pfam02599 1162668005800 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK07701 1162668005801 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1162668005802 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1162668005803 Flagellar hook-associated protein [Cell motility and secretion]; Region: FlgK; COG1256 1162668005804 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1162668005805 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1162668005806 FlgN protein; Region: FlgN; cl09176 1162668005807 Anti-sigma-28 factor, FlgM; Region: FlgM; pfam04316 1162668005808 flagellin; Provisional; Region: PRK12802 1162668005809 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1162668005810 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1162668005811 Rod binding protein; Region: Rod-binding; cl01626 1162668005812 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 1162668005813 Flagellar P-ring protein; Region: FlgI; pfam02119 1162668005814 Flagellar L-ring protein; Region: FlgH; cl17277 1162668005815 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 1162668005816 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 1162668005817 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1162668005818 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1162668005819 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 1162668005820 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1162668005821 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 1162668005822 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 1162668005823 AAA domain; Region: AAA_30; pfam13604 1162668005824 Family description; Region: UvrD_C_2; pfam13538 1162668005825 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303 1162668005826 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1162668005827 dihydrodipicolinate reductase; Provisional; Region: PRK00048 1162668005828 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1162668005829 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1162668005830 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1162668005831 dihydrodipicolinate synthase; Region: dapA; TIGR00674 1162668005832 dimer interface [polypeptide binding]; other site 1162668005833 active site 1162668005834 catalytic residue [active] 1162668005835 diaminopimelate decarboxylase; Region: lysA; TIGR01048 1162668005836 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1162668005837 active site 1162668005838 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1162668005839 substrate binding site [chemical binding]; other site 1162668005840 catalytic residues [active] 1162668005841 dimer interface [polypeptide binding]; other site 1162668005842 argininosuccinate lyase; Provisional; Region: PRK00855 1162668005843 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1162668005844 active sites [active] 1162668005845 tetramer interface [polypeptide binding]; other site 1162668005846 argininosuccinate synthase; Provisional; Region: PRK13820 1162668005847 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 1162668005848 ANP binding site [chemical binding]; other site 1162668005849 Substrate Binding Site II [chemical binding]; other site 1162668005850 Substrate Binding Site I [chemical binding]; other site 1162668005851 ornithine carbamoyltransferase; Provisional; Region: PRK00779 1162668005852 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1162668005853 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1162668005854 acetylornithine aminotransferase; Provisional; Region: PRK02627 1162668005855 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1162668005856 inhibitor-cofactor binding pocket; inhibition site 1162668005857 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1162668005858 catalytic residue [active] 1162668005859 Ion channel; Region: Ion_trans_2; pfam07885 1162668005860 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1162668005861 TrkA-N domain; Region: TrkA_N; pfam02254 1162668005862 TrkA-C domain; Region: TrkA_C; pfam02080 1162668005863 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1162668005864 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1162668005865 putative substrate translocation pore; other site 1162668005866 GldM N-terminal domain; Region: GldM_N; pfam12081 1162668005867 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 1162668005868 UbiA prenyltransferase family; Region: UbiA; pfam01040 1162668005869 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 1162668005870 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1162668005871 FeS/SAM binding site; other site 1162668005872 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 1162668005873 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1162668005874 S-adenosylmethionine binding site [chemical binding]; other site 1162668005875 exopolyphosphatase; Region: exo_poly_only; TIGR03706 1162668005876 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1162668005877 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1162668005878 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 1162668005879 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1162668005880 TMP-binding site; other site 1162668005881 ATP-binding site [chemical binding]; other site 1162668005882 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 1162668005883 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1162668005884 TMP-binding site; other site 1162668005885 ATP-binding site [chemical binding]; other site 1162668005886 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 1162668005887 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1162668005888 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1162668005889 dimer interface [polypeptide binding]; other site 1162668005890 active site 1162668005891 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1162668005892 folate binding site [chemical binding]; other site 1162668005893 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 1162668005894 ATP cone domain; Region: ATP-cone; pfam03477 1162668005895 primosome assembly protein PriA; Validated; Region: PRK05580 1162668005896 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1162668005897 ATP binding site [chemical binding]; other site 1162668005898 putative Mg++ binding site [ion binding]; other site 1162668005899 helicase superfamily c-terminal domain; Region: HELICc; smart00490 1162668005900 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161 1162668005901 Peptidase family M50; Region: Peptidase_M50; pfam02163 1162668005902 active site 1162668005903 putative substrate binding region [chemical binding]; other site 1162668005904 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 1162668005905 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 1162668005906 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1162668005907 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 1162668005908 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1162668005909 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1162668005910 catalytic residues [active] 1162668005911 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1162668005912 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1162668005913 catalytic residues [active] 1162668005914 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 1162668005915 ResB-like family; Region: ResB; pfam05140 1162668005916 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 1162668005917 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 1162668005918 mce related protein; Region: MCE; pfam02470 1162668005919 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 1162668005920 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 1162668005921 Walker A/P-loop; other site 1162668005922 ATP binding site [chemical binding]; other site 1162668005923 Q-loop/lid; other site 1162668005924 ABC transporter signature motif; other site 1162668005925 Walker B; other site 1162668005926 D-loop; other site 1162668005927 H-loop/switch region; other site 1162668005928 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1162668005929 Permease; Region: Permease; pfam02405 1162668005930 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1162668005931 alanine racemase; Reviewed; Region: alr; PRK00053 1162668005932 active site 1162668005933 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1162668005934 dimer interface [polypeptide binding]; other site 1162668005935 substrate binding site [chemical binding]; other site 1162668005936 catalytic residues [active] 1162668005937 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1162668005938 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1162668005939 hinge region; other site 1162668005940 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1162668005941 putative nucleotide binding site [chemical binding]; other site 1162668005942 uridine monophosphate binding site [chemical binding]; other site 1162668005943 homohexameric interface [polypeptide binding]; other site 1162668005944 elongation factor Ts; Reviewed; Region: tsf; PRK12332 1162668005945 Elongation factor TS; Region: EF_TS; pfam00889 1162668005946 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1162668005947 rRNA interaction site [nucleotide binding]; other site 1162668005948 S8 interaction site; other site 1162668005949 putative laminin-1 binding site; other site 1162668005950 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 1162668005951 heterotetramer interface [polypeptide binding]; other site 1162668005952 active site pocket [active] 1162668005953 cleavage site 1162668005954 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 1162668005955 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1162668005956 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1162668005957 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1162668005958 23S rRNA interface [nucleotide binding]; other site 1162668005959 L3 interface [polypeptide binding]; other site 1162668005960 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 1162668005961 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 1162668005962 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1162668005963 FeS/SAM binding site; other site 1162668005964 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 1162668005965 Dihydroneopterin aldolase; Region: FolB; pfam02152 1162668005966 active site 1162668005967 ribonuclease G; Provisional; Region: PRK11712 1162668005968 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1162668005969 homodimer interface [polypeptide binding]; other site 1162668005970 oligonucleotide binding site [chemical binding]; other site 1162668005971 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 1162668005972 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 1162668005973 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1162668005974 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1162668005975 rod shape-determining protein MreC; Provisional; Region: PRK13922 1162668005976 rod shape-determining protein MreC; Region: MreC; pfam04085 1162668005977 rod shape-determining protein MreB; Provisional; Region: PRK13927 1162668005978 MreB and similar proteins; Region: MreB_like; cd10225 1162668005979 nucleotide binding site [chemical binding]; other site 1162668005980 Mg binding site [ion binding]; other site 1162668005981 putative protofilament interaction site [polypeptide binding]; other site 1162668005982 RodZ interaction site [polypeptide binding]; other site 1162668005983 RDD family; Region: RDD; pfam06271 1162668005984 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 1162668005985 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1162668005986 substrate binding site [chemical binding]; other site 1162668005987 hexamer interface [polypeptide binding]; other site 1162668005988 metal binding site [ion binding]; metal-binding site 1162668005989 Peptidase family M48; Region: Peptidase_M48; cl12018 1162668005990 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1162668005991 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1162668005992 putative active site [active] 1162668005993 substrate binding site [chemical binding]; other site 1162668005994 putative cosubstrate binding site; other site 1162668005995 catalytic site [active] 1162668005996 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1162668005997 substrate binding site [chemical binding]; other site 1162668005998 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1162668005999 active site 1162668006000 catalytic residues [active] 1162668006001 metal binding site [ion binding]; metal-binding site 1162668006002 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 1162668006003 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 1162668006004 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 1162668006005 catalytic residues [active] 1162668006006 magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517 1162668006007 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 1162668006008 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1162668006009 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1162668006010 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1162668006011 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1162668006012 PEP-CTERM motif; Region: VPEP; pfam07589 1162668006013 Patatin-like phospholipase; includes PNPLA8, PNPLA9, and Pat17; Region: Pat17_PNPLA8_PNPLA9_like; cd07199 1162668006014 active site 1162668006015 nucleophile elbow; other site 1162668006016 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 1162668006017 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 1162668006018 putative active site; other site 1162668006019 catalytic residue [active] 1162668006020 CO dehydrogenase beta subunit/acetyl-CoA synthase epsilon subunit; Region: CO_dh; pfam02552 1162668006021 CO dehydrogenase beta subunit/acetyl-CoA synthase epsilon subunit; Region: CO_dh; pfam02552 1162668006022 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1162668006023 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 1162668006024 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 1162668006025 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 1162668006026 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 1162668006027 Nitrogen regulatory protein P-II; Region: P-II; cl00412 1162668006028 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1162668006029 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1162668006030 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1162668006031 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1162668006032 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 1162668006033 PIN domain; Region: PIN_3; pfam13470 1162668006034 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 1162668006035 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1162668006036 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1162668006037 HlyD family secretion protein; Region: HlyD_3; pfam13437 1162668006038 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1162668006039 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1162668006040 active site 1162668006041 phosphorylation site [posttranslational modification] 1162668006042 intermolecular recognition site; other site 1162668006043 dimerization interface [polypeptide binding]; other site 1162668006044 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1162668006045 Walker A motif; other site 1162668006046 ATP binding site [chemical binding]; other site 1162668006047 Walker B motif; other site 1162668006048 arginine finger; other site 1162668006049 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1162668006050 Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571 1162668006051 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 1162668006052 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1162668006053 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1162668006054 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1162668006055 HlyD family secretion protein; Region: HlyD_3; pfam13437 1162668006056 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1162668006057 iron-sulfur cluster [ion binding]; other site 1162668006058 [2Fe-2S] cluster binding site [ion binding]; other site 1162668006059 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 1162668006060 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 1162668006061 ligand binding site; other site 1162668006062 oligomer interface; other site 1162668006063 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 1162668006064 dimer interface [polypeptide binding]; other site 1162668006065 N-terminal domain interface [polypeptide binding]; other site 1162668006066 sulfate 1 binding site; other site 1162668006067 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 1162668006068 N-terminal catalytic domain of thermoactive amylopullulanases; glycoside hydrolase family 57 (GH57); Region: GH57N_APU; cd10796 1162668006069 putative active site [active] 1162668006070 catalytic site [active] 1162668006071 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 1162668006072 Glycosyl hydrolase family 57; Region: Glyco_hydro_57; pfam03065 1162668006073 Domain of unknown function (DUF1925); Region: DUF1925; pfam09094 1162668006074 Domain of unknown function (DUF1926); Region: DUF1926; pfam09095 1162668006075 ADP-glucose phosphorylase; Region: PLN02643 1162668006076 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 1162668006077 dimer interface [polypeptide binding]; other site 1162668006078 active site 1162668006079 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 1162668006080 active site 1162668006081 intersubunit interface [polypeptide binding]; other site 1162668006082 zinc binding site [ion binding]; other site 1162668006083 Na+ binding site [ion binding]; other site 1162668006084 N-terminal catalytic domain of alpha-amylase ( AmyC ) and similar proteins; Region: GH57N_AmyC_like; cd10792 1162668006085 Uncharacterized conserved protein [Function unknown]; Region: COG1543 1162668006086 active site 1162668006087 substrate binding site [chemical binding]; other site 1162668006088 catalytic site [active] 1162668006089 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 1162668006090 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 1162668006091 Winged helix-turn helix; Region: HTH_29; pfam13551 1162668006092 Rhodopirellula transposase DDE domain; Region: DDE_Tnp_ISAZ013; pfam07592 1162668006093 Domain of unknown function (DUF4415); Region: DUF4415; cl01401 1162668006094 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1162668006095 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1162668006096 DNA binding residues [nucleotide binding] 1162668006097 dimerization interface [polypeptide binding]; other site 1162668006098 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 1162668006099 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 1162668006100 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1162668006101 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1162668006102 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1162668006103 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 1162668006104 active site 1162668006105 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1162668006106 active site 1162668006107 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1162668006108 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1162668006109 active site 1162668006110 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1162668006111 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1162668006112 glutaminase active site [active] 1162668006113 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1162668006114 dimer interface [polypeptide binding]; other site 1162668006115 active site 1162668006116 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1162668006117 dimer interface [polypeptide binding]; other site 1162668006118 active site 1162668006119 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 1162668006120 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1162668006121 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1162668006122 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 1162668006123 Vi polysaccharide biosynthesis protein TviC; Provisional; Region: PRK15181 1162668006124 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1162668006125 NAD(P) binding site [chemical binding]; other site 1162668006126 active site 1162668006127 sugar transferase, PEP-CTERM system associated; Region: EpsB_2; TIGR03013 1162668006128 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1162668006129 PEP-CTERM motif; Region: VPEP; pfam07589 1162668006130 carbamoyl phosphate synthase-like protein; Provisional; Region: PRK12767 1162668006131 Transposase; Region: HTH_Tnp_1; cl17663 1162668006132 Divergent AAA domain; Region: AAA_4; pfam04326 1162668006133 TM1410 hypothetical-related protein; Region: DUF297; pfam03537 1162668006134 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 1162668006135 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 1162668006136 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1162668006137 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1162668006138 active site 1162668006139 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1162668006140 This family is most closely related to the GT1 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis; Region: GT1_WbnK_like; cd03807 1162668006141 putative ADP-binding pocket [chemical binding]; other site 1162668006142 PEP-CTERM motif; Region: VPEP; pfam07589 1162668006143 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 1162668006144 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1162668006145 UDP-galactopyranose mutase; Region: GLF; pfam03275 1162668006146 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1162668006147 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_b; cd04185 1162668006148 Probable Catalytic site; other site 1162668006149 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 1162668006150 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 1162668006151 SLBB domain; Region: SLBB; pfam10531 1162668006152 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 1162668006153 Vta1 like; Region: DUF605; pfam04652 1162668006154 polysaccharide chain length determinant protein, PEP-CTERM locus subfamily; Region: pepcterm_ChnLen; TIGR03007 1162668006155 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 1162668006156 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1162668006157 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1162668006158 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 1162668006159 O-Antigen ligase; Region: Wzy_C; pfam04932 1162668006160 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1162668006161 This family is most closely related to the GT1 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis; Region: GT1_WbnK_like; cd03807 1162668006162 putative ADP-binding pocket [chemical binding]; other site 1162668006163 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 1162668006164 putative active site [active] 1162668006165 putative metal binding site [ion binding]; other site 1162668006166 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 1162668006167 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1162668006168 putative ADP-binding pocket [chemical binding]; other site 1162668006169 CESA_like_1 is a member of the cellulose synthase (CESA) superfamily; Region: CESA_like_1; cd06439 1162668006170 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1162668006171 DXD motif; other site 1162668006172 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1162668006173 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 1162668006174 putative active site [active] 1162668006175 putative metal binding site [ion binding]; other site 1162668006176 Domain of unknown function (DUF4091); Region: DUF4091; pfam13320 1162668006177 putative PEP-CTERM system histidine kinase; Region: PEP_his_kin; TIGR02916 1162668006178 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1162668006179 ATP binding site [chemical binding]; other site 1162668006180 Mg2+ binding site [ion binding]; other site 1162668006181 G-X-G motif; other site 1162668006182 Predicted membrane protein [Function unknown]; Region: COG4083; cl15694 1162668006183 Protein of unknown function (DUF3485); Region: DUF3485; pfam11984 1162668006184 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1162668006185 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1162668006186 active site 1162668006187 phosphorylation site [posttranslational modification] 1162668006188 intermolecular recognition site; other site 1162668006189 dimerization interface [polypeptide binding]; other site 1162668006190 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1162668006191 Walker A motif; other site 1162668006192 ATP binding site [chemical binding]; other site 1162668006193 Walker B motif; other site 1162668006194 arginine finger; other site 1162668006195 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1162668006196 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 1162668006197 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1162668006198 binding surface 1162668006199 TPR motif; other site 1162668006200 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1162668006201 binding surface 1162668006202 TPR motif; other site 1162668006203 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1162668006204 binding surface 1162668006205 TPR motif; other site 1162668006206 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1162668006207 binding surface 1162668006208 TPR motif; other site 1162668006209 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1162668006210 binding surface 1162668006211 TPR motif; other site 1162668006212 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1162668006213 binding surface 1162668006214 TPR motif; other site 1162668006215 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1162668006216 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1162668006217 active site 1162668006218 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1162668006219 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1162668006220 active site 1162668006221 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1162668006222 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1162668006223 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1162668006224 Domain of unknown function (DUF4422); Region: DUF4422; pfam14393 1162668006225 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1162668006226 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1162668006227 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1162668006228 Walker A/P-loop; other site 1162668006229 ATP binding site [chemical binding]; other site 1162668006230 Q-loop/lid; other site 1162668006231 ABC transporter signature motif; other site 1162668006232 Walker B; other site 1162668006233 D-loop; other site 1162668006234 H-loop/switch region; other site 1162668006235 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1162668006236 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1162668006237 active site 1162668006238 hypothetical protein; Provisional; Region: PRK14852 1162668006239 hypothetical protein; Validated; Region: PRK08223 1162668006240 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 1162668006241 ATP binding site [chemical binding]; other site 1162668006242 substrate interface [chemical binding]; other site 1162668006243 MoeZ/MoeB domain; Region: MoeZ_MoeB; pfam05237 1162668006244 Winged helix-turn helix; Region: HTH_29; pfam13551 1162668006245 Homeodomain-like domain; Region: HTH_23; pfam13384 1162668006246 Integrase core domain; Region: rve; pfam00665 1162668006247 Domain of unknown function (DUF4415); Region: DUF4415; pfam14384 1162668006248 Protein of unknown function (DUF770); Region: DUF770; pfam05591 1162668006249 type VI secretion protein, EvpB/VC_A0108 family; Region: VI_chp_2; TIGR03355 1162668006250 Protein of unknown function (DUF877); Region: DUF877; pfam05943 1162668006251 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 1162668006252 type VI secretion system lysozyme-like protein; Region: VI_zyme; TIGR03357 1162668006253 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 1162668006254 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 1162668006255 Protein of unknown function (DUF1305); Region: DUF1305; pfam06996 1162668006256 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 1162668006257 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1162668006258 Walker A motif; other site 1162668006259 ATP binding site [chemical binding]; other site 1162668006260 Walker B motif; other site 1162668006261 arginine finger; other site 1162668006262 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1162668006263 Walker A motif; other site 1162668006264 ATP binding site [chemical binding]; other site 1162668006265 Walker B motif; other site 1162668006266 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1162668006267 Rhs element Vgr protein; Region: vgr_GE; TIGR01646 1162668006268 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 1162668006269 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1162668006270 Uncharacterized protein conserved in bacteria (DUF2169); Region: DUF2169; pfam09937 1162668006271 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1162668006272 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1162668006273 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1162668006274 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1162668006275 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1162668006276 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1162668006277 Protein of unknown function (DUF3540); Region: DUF3540; pfam12059 1162668006278 Domain of unknown function (DUF4150); Region: DUF4150; pfam13665 1162668006279 Type VI secretion lipoprotein; Region: T6SS-SciN; cl01405 1162668006280 type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353 1162668006281 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 1162668006282 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850 1162668006283 ImcF-related N-terminal domain; Region: ImcF-related_N; pfam14331 1162668006284 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 1162668006285 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 1162668006286 type VI secretion-associated protein, VC_A0119 family; Region: VI_chp_7; TIGR03362 1162668006287 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1162668006288 cyclase homology domain; Region: CHD; cd07302 1162668006289 dimer interface [polypeptide binding]; other site 1162668006290 nucleotidyl binding site; other site 1162668006291 metal binding site [ion binding]; metal-binding site 1162668006292 Predicted ATPase [General function prediction only]; Region: COG3899 1162668006293 AAA ATPase domain; Region: AAA_16; pfam13191 1162668006294 Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310 1162668006295 Fic/DOC family; Region: Fic; cl00960 1162668006296 Bacterial transcriptional activator domain; Region: BTAD; smart01043 1162668006297 cyclase homology domain; Region: CHD; cd07302 1162668006298 dimer interface [polypeptide binding]; other site 1162668006299 nucleotidyl binding site; other site 1162668006300 metal binding site [ion binding]; metal-binding site 1162668006301 AAA ATPase domain; Region: AAA_16; pfam13191 1162668006302 putative sialic acid transporter; Region: 2A0112; TIGR00891 1162668006303 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1162668006304 putative substrate translocation pore; other site 1162668006305 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1162668006306 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1162668006307 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1162668006308 GAF domain; Region: GAF; pfam01590 1162668006309 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1162668006310 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1162668006311 metal binding site [ion binding]; metal-binding site 1162668006312 active site 1162668006313 I-site; other site 1162668006314 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1162668006315 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 1162668006316 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1162668006317 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1162668006318 Cytochrome c; Region: Cytochrom_C; pfam00034 1162668006319 Cytochrome c [Energy production and conversion]; Region: COG3258 1162668006320 Cytochrome c; Region: Cytochrom_C; pfam00034 1162668006321 Response regulator receiver domain; Region: Response_reg; pfam00072 1162668006322 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1162668006323 active site 1162668006324 phosphorylation site [posttranslational modification] 1162668006325 intermolecular recognition site; other site 1162668006326 dimerization interface [polypeptide binding]; other site 1162668006327 PAS fold; Region: PAS_4; pfam08448 1162668006328 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1162668006329 putative active site [active] 1162668006330 heme pocket [chemical binding]; other site 1162668006331 Response regulator receiver domain; Region: Response_reg; pfam00072 1162668006332 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1162668006333 active site 1162668006334 phosphorylation site [posttranslational modification] 1162668006335 intermolecular recognition site; other site 1162668006336 dimerization interface [polypeptide binding]; other site 1162668006337 CHASE3 domain; Region: CHASE3; pfam05227 1162668006338 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1162668006339 PAS domain; Region: PAS_9; pfam13426 1162668006340 putative active site [active] 1162668006341 heme pocket [chemical binding]; other site 1162668006342 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1162668006343 dimer interface [polypeptide binding]; other site 1162668006344 phosphorylation site [posttranslational modification] 1162668006345 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1162668006346 ATP binding site [chemical binding]; other site 1162668006347 Mg2+ binding site [ion binding]; other site 1162668006348 G-X-G motif; other site 1162668006349 hypothetical protein; Provisional; Region: PRK10279 1162668006350 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 1162668006351 active site 1162668006352 nucleophile elbow; other site 1162668006353 enoyl-CoA hydratase; Validated; Region: PRK08788 1162668006354 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1162668006355 substrate binding site [chemical binding]; other site 1162668006356 oxyanion hole (OAH) forming residues; other site 1162668006357 trimer interface [polypeptide binding]; other site 1162668006358 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1162668006359 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1162668006360 dimer interface [polypeptide binding]; other site 1162668006361 phosphorylation site [posttranslational modification] 1162668006362 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1162668006363 ATP binding site [chemical binding]; other site 1162668006364 Mg2+ binding site [ion binding]; other site 1162668006365 G-X-G motif; other site 1162668006366 Response regulator receiver domain; Region: Response_reg; pfam00072 1162668006367 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1162668006368 active site 1162668006369 phosphorylation site [posttranslational modification] 1162668006370 intermolecular recognition site; other site 1162668006371 dimerization interface [polypeptide binding]; other site 1162668006372 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 1162668006373 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 1162668006374 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1162668006375 active site 1162668006376 phosphorylation site [posttranslational modification] 1162668006377 intermolecular recognition site; other site 1162668006378 dimerization interface [polypeptide binding]; other site 1162668006379 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1162668006380 Zn2+ binding site [ion binding]; other site 1162668006381 Mg2+ binding site [ion binding]; other site 1162668006382 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1162668006383 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 1162668006384 Clp amino terminal domain; Region: Clp_N; pfam02861 1162668006385 Clp amino terminal domain; Region: Clp_N; pfam02861 1162668006386 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1162668006387 Walker A motif; other site 1162668006388 ATP binding site [chemical binding]; other site 1162668006389 Walker B motif; other site 1162668006390 arginine finger; other site 1162668006391 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1162668006392 Walker A motif; other site 1162668006393 ATP binding site [chemical binding]; other site 1162668006394 Walker B motif; other site 1162668006395 arginine finger; other site 1162668006396 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1162668006397 Cytochrome c [Energy production and conversion]; Region: COG3258 1162668006398 Cytochrome c; Region: Cytochrom_C; pfam00034 1162668006399 Cytochrome c [Energy production and conversion]; Region: COG3258 1162668006400 Cytochrome c; Region: Cytochrom_C; pfam00034 1162668006401 Cytochrome c; Region: Cytochrom_C; cl11414 1162668006402 Cytochrome c; Region: Cytochrom_C; cl11414 1162668006403 PAS fold; Region: PAS_4; pfam08448 1162668006404 PAS domain S-box; Region: sensory_box; TIGR00229 1162668006405 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1162668006406 putative active site [active] 1162668006407 heme pocket [chemical binding]; other site 1162668006408 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1162668006409 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1162668006410 metal binding site [ion binding]; metal-binding site 1162668006411 active site 1162668006412 I-site; other site 1162668006413 PAS domain S-box; Region: sensory_box; TIGR00229 1162668006414 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1162668006415 putative active site [active] 1162668006416 heme pocket [chemical binding]; other site 1162668006417 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1162668006418 GAF domain; Region: GAF; pfam01590 1162668006419 PAS domain S-box; Region: sensory_box; TIGR00229 1162668006420 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1162668006421 putative active site [active] 1162668006422 heme pocket [chemical binding]; other site 1162668006423 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1162668006424 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1162668006425 metal binding site [ion binding]; metal-binding site 1162668006426 active site 1162668006427 I-site; other site 1162668006428 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1162668006429 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1162668006430 DNA binding residues [nucleotide binding] 1162668006431 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 1162668006432 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1162668006433 HSP70 interaction site [polypeptide binding]; other site 1162668006434 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1162668006435 substrate binding site [polypeptide binding]; other site 1162668006436 dimer interface [polypeptide binding]; other site 1162668006437 Aspartate oxidase [Coenzyme metabolism]; Region: NadB; COG0029 1162668006438 L-aspartate oxidase; Provisional; Region: PRK06175 1162668006439 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1162668006440 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1162668006441 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1162668006442 HIGH motif; other site 1162668006443 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1162668006444 active site 1162668006445 KMSKS motif; other site 1162668006446 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1162668006447 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952 1162668006448 Uncharacterized protein family UPF0547; Region: UPF0547; pfam10571 1162668006449 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1162668006450 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1162668006451 ligand binding site [chemical binding]; other site 1162668006452 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, delta subunit [Energy production and conversion]; Region: COG1144 1162668006453 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 1162668006454 Thiamine pyrophosphate (TPP family), Pyruvate ferredoxin/flavodoxin oxidoreductase (PFOR) subfamily, TPP-binding module; PFOR catalyzes the oxidative decarboxylation of pyruvate to form acetyl-CoA, a crucial step in many metabolic pathways. Archaea; Region: TPP_PFOR; cd02018 1162668006455 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit [Energy production and conversion]; Region: PorB; COG1013 1162668006456 TPP-binding site [chemical binding]; other site 1162668006457 dimer interface [polypeptide binding]; other site 1162668006458 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, alpha subunit [Energy production and conversion]; Region: PorA; COG0674 1162668006459 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 1162668006460 dimer interface [polypeptide binding]; other site 1162668006461 PYR/PP interface [polypeptide binding]; other site 1162668006462 TPP binding site [chemical binding]; other site 1162668006463 substrate binding site [chemical binding]; other site 1162668006464 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1162668006465 Domain of unknown function (DUF1841); Region: DUF1841; pfam08897 1162668006466 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 1162668006467 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 1162668006468 Thiamine pyrophosphate (TPP family), Pyruvate ferredoxin/flavodoxin oxidoreductase (PFOR) subfamily, TPP-binding module; PFOR catalyzes the oxidative decarboxylation of pyruvate to form acetyl-CoA, a crucial step in many metabolic pathways. Archaea; Region: TPP_PFOR; cd02018 1162668006469 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit [Energy production and conversion]; Region: PorB; COG1013 1162668006470 TPP-binding site [chemical binding]; other site 1162668006471 dimer interface [polypeptide binding]; other site 1162668006472 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, alpha subunit [Energy production and conversion]; Region: PorA; COG0674 1162668006473 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 1162668006474 dimer interface [polypeptide binding]; other site 1162668006475 PYR/PP interface [polypeptide binding]; other site 1162668006476 TPP binding site [chemical binding]; other site 1162668006477 substrate binding site [chemical binding]; other site 1162668006478 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1162668006479 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1162668006480 HSP70 interaction site [polypeptide binding]; other site 1162668006481 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 1162668006482 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1162668006483 inhibitor-cofactor binding pocket; inhibition site 1162668006484 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1162668006485 catalytic residue [active] 1162668006486 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1162668006487 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 1162668006488 dimer interface [polypeptide binding]; other site 1162668006489 active site 1162668006490 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 1162668006491 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 1162668006492 active site 1162668006493 nucleotide binding site [chemical binding]; other site 1162668006494 HIGH motif; other site 1162668006495 KMSKS motif; other site 1162668006496 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 1162668006497 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 1162668006498 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1162668006499 ATP binding site [chemical binding]; other site 1162668006500 putative Mg++ binding site [ion binding]; other site 1162668006501 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1162668006502 nucleotide binding region [chemical binding]; other site 1162668006503 ATP-binding site [chemical binding]; other site 1162668006504 TRCF domain; Region: TRCF; pfam03461 1162668006505 SurA N-terminal domain; Region: SurA_N_3; cl07813 1162668006506 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 1162668006507 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 1162668006508 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 1162668006509 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 1162668006510 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 1162668006511 SurA N-terminal domain; Region: SurA_N; pfam09312 1162668006512 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1162668006513 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 1162668006514 G1 box; other site 1162668006515 GTP/Mg2+ binding site [chemical binding]; other site 1162668006516 Switch I region; other site 1162668006517 G2 box; other site 1162668006518 G3 box; other site 1162668006519 Switch II region; other site 1162668006520 G4 box; other site 1162668006521 G5 box; other site 1162668006522 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 1162668006523 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1162668006524 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 1162668006525 active site 1162668006526 Phosphotransferase enzyme family; Region: APH; pfam01636 1162668006527 Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178 1162668006528 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 1162668006529 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1162668006530 DNA binding site [nucleotide binding] 1162668006531 catalytic residue [active] 1162668006532 H2TH interface [polypeptide binding]; other site 1162668006533 putative catalytic residues [active] 1162668006534 turnover-facilitating residue; other site 1162668006535 intercalation triad [nucleotide binding]; other site 1162668006536 8OG recognition residue [nucleotide binding]; other site 1162668006537 putative reading head residues; other site 1162668006538 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1162668006539 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1162668006540 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 1162668006541 dinuclear metal binding motif [ion binding]; other site 1162668006542 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1162668006543 SdiA-regulated; Region: SdiA-regulated; cd09971 1162668006544 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 1162668006545 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1162668006546 PAS domain; Region: PAS_9; pfam13426 1162668006547 putative active site [active] 1162668006548 heme pocket [chemical binding]; other site 1162668006549 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1162668006550 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1162668006551 metal binding site [ion binding]; metal-binding site 1162668006552 active site 1162668006553 I-site; other site 1162668006554 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 1162668006555 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1162668006556 ATP binding site [chemical binding]; other site 1162668006557 putative Mg++ binding site [ion binding]; other site 1162668006558 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1162668006559 nucleotide binding region [chemical binding]; other site 1162668006560 ATP-binding site [chemical binding]; other site 1162668006561 PAS fold; Region: PAS_4; pfam08448 1162668006562 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1162668006563 putative active site [active] 1162668006564 heme pocket [chemical binding]; other site 1162668006565 GAF domain; Region: GAF_2; pfam13185 1162668006566 GAF domain; Region: GAF; cl17456 1162668006567 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1162668006568 GAF domain; Region: GAF; pfam01590 1162668006569 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1162668006570 PAS domain; Region: PAS_9; pfam13426 1162668006571 putative active site [active] 1162668006572 heme pocket [chemical binding]; other site 1162668006573 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1162668006574 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1162668006575 metal binding site [ion binding]; metal-binding site 1162668006576 active site 1162668006577 I-site; other site 1162668006578 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1162668006579 PAS domain S-box; Region: sensory_box; TIGR00229 1162668006580 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1162668006581 putative active site [active] 1162668006582 heme pocket [chemical binding]; other site 1162668006583 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1162668006584 PAS domain; Region: PAS_9; pfam13426 1162668006585 putative active site [active] 1162668006586 heme pocket [chemical binding]; other site 1162668006587 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1162668006588 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1162668006589 metal binding site [ion binding]; metal-binding site 1162668006590 active site 1162668006591 I-site; other site 1162668006592 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1162668006593 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 1162668006594 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1162668006595 active site 1162668006596 HIGH motif; other site 1162668006597 nucleotide binding site [chemical binding]; other site 1162668006598 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1162668006599 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1162668006600 active site 1162668006601 KMSKS motif; other site 1162668006602 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 1162668006603 tRNA binding surface [nucleotide binding]; other site 1162668006604 anticodon binding site; other site 1162668006605 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1162668006606 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 1162668006607 TPR repeat; Region: TPR_11; pfam13414 1162668006608 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1162668006609 TPR motif; other site 1162668006610 binding surface 1162668006611 TPR repeat; Region: TPR_11; pfam13414 1162668006612 TPR repeat; Region: TPR_11; pfam13414 1162668006613 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1162668006614 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1162668006615 RNA binding surface [nucleotide binding]; other site 1162668006616 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1162668006617 active site 1162668006618 Uncharacterized conserved protein [Function unknown]; Region: COG4198 1162668006619 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 1162668006620 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1162668006621 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1162668006622 substrate binding pocket [chemical binding]; other site 1162668006623 chain length determination region; other site 1162668006624 substrate-Mg2+ binding site; other site 1162668006625 catalytic residues [active] 1162668006626 aspartate-rich region 1; other site 1162668006627 active site lid residues [active] 1162668006628 aspartate-rich region 2; other site 1162668006629 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160 1162668006630 Peptidase family M50; Region: Peptidase_M50; pfam02163 1162668006631 active site 1162668006632 putative substrate binding region [chemical binding]; other site 1162668006633 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1162668006634 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 1162668006635 active site 1162668006636 dimerization interface [polypeptide binding]; other site 1162668006637 phosphoenolpyruvate carboxylase, archaeal type; Region: PEPCase_arch; TIGR02751 1162668006638 Phosphoenolpyruvate carboxylase; Region: PEPcase_2; pfam14010 1162668006639 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 1162668006640 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 1162668006641 Bifunctional nuclease; Region: DNase-RNase; pfam02577 1162668006642 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1162668006643 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1162668006644 catalytic loop [active] 1162668006645 iron binding site [ion binding]; other site 1162668006646 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 1162668006647 CPxP motif; other site 1162668006648 ribonuclease III; Reviewed; Region: rnc; PRK00102 1162668006649 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1162668006650 dimerization interface [polypeptide binding]; other site 1162668006651 active site 1162668006652 metal binding site [ion binding]; metal-binding site 1162668006653 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1162668006654 dsRNA binding site [nucleotide binding]; other site 1162668006655 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1162668006656 active site 1162668006657 catalytic site [active] 1162668006658 substrate binding site [chemical binding]; other site 1162668006659 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 1162668006660 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1162668006661 Ligand Binding Site [chemical binding]; other site 1162668006662 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 1162668006663 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 1162668006664 ParB-like nuclease domain; Region: ParB; smart00470 1162668006665 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1162668006666 non-specific DNA binding site [nucleotide binding]; other site 1162668006667 salt bridge; other site 1162668006668 sequence-specific DNA binding site [nucleotide binding]; other site 1162668006669 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1162668006670 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1162668006671 P-loop; other site 1162668006672 Magnesium ion binding site [ion binding]; other site 1162668006673 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1162668006674 Magnesium ion binding site [ion binding]; other site 1162668006675 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; cl17726 1162668006676 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 1162668006677 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 1162668006678 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 1162668006679 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 1162668006680 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 1162668006681 trmE is a tRNA modification GTPase; Region: trmE; cd04164 1162668006682 G1 box; other site 1162668006683 GTP/Mg2+ binding site [chemical binding]; other site 1162668006684 Switch I region; other site 1162668006685 G2 box; other site 1162668006686 Switch II region; other site 1162668006687 G3 box; other site 1162668006688 G4 box; other site 1162668006689 G5 box; other site 1162668006690 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 1162668006691 membrane protein insertase; Provisional; Region: PRK01318 1162668006692 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 1162668006693 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1162668006694 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1162668006695 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1162668006696 TPR repeat; Region: TPR_11; pfam13414 1162668006697 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1162668006698 TPR motif; other site 1162668006699 binding surface 1162668006700 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1162668006701 binding surface 1162668006702 TPR motif; other site 1162668006703 nitrogenase reductase; Reviewed; Region: nifH; PRK13234 1162668006704 NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040 1162668006705 Nucleotide-binding sites [chemical binding]; other site 1162668006706 Walker A motif; other site 1162668006707 Switch I region of nucleotide binding site; other site 1162668006708 Fe4S4 binding sites [ion binding]; other site 1162668006709 Switch II region of nucleotide binding site; other site 1162668006710 Nitrogenase molybdenum-iron protein, alpha and beta chains [Energy production and conversion]; Region: NifD; COG2710 1162668006711 Nitrogenase_MoFe_alpha_II: Nitrogenase MoFe protein, beta subunit. A group of proteins similar to the alpha subunit of the MoFe protein of the molybdenum (Mo-) nitrogenase. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to...; Region: Nitrogenase_MoFe_alpha; cd01976 1162668006712 MoFe protein alpha/beta subunit interactions; other site 1162668006713 Alpha subunit P cluster binding residues; other site 1162668006714 FeMoco binding residues [chemical binding]; other site 1162668006715 MoFe protein alpha subunit/Fe protein contacts; other site 1162668006716 MoFe protein dimer/ dimer interactions; other site 1162668006717 nitrogenase molybdenum-iron protein beta chain; Region: nifK; TIGR01286 1162668006718 Domain of unknown function (DUF3364); Region: DUF3364; pfam11844 1162668006719 Nitrogenase_MoFe_beta: Nitrogenase MoFe protein, beta subunit. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to ammonia. The Molybdenum (Mo-) nitrogenase is the most widespread and best characterized of these systems; Region: Nitrogenase_MoFe_beta; cd01974 1162668006720 MoFe protein beta/alpha subunit interactions; other site 1162668006721 Beta subunit P cluster binding residues; other site 1162668006722 MoFe protein beta subunit/Fe protein contacts; other site 1162668006723 MoFe protein dimer/ dimer interactions; other site 1162668006724 nitrogenase molybdenum-cofactor biosynthesis protein NifE; Provisional; Region: PRK14478 1162668006725 nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283 1162668006726 Nitrogenase_nifN1: A subgroup of the NifN subunit of the NifEN complex: NifN forms an alpha2beta2 tetramer with NifE. NifN and nifE are structurally homologous to nitrogenase MoFe protein beta and alpha subunits respectively. NifEN participates in the...; Region: Nitrogenase_NifN_1; cd01966 1162668006727 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 1162668006728 NifX belongs to a family of iron-molybdenum cluster-binding proteins that includes NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. The protein...; Region: NifX; cd00853 1162668006729 Protein of unknown function, DUF269; Region: DUF269; pfam03270 1162668006730 nitrogenase cofactor biosynthesis protein NifB; Region: nifB; TIGR01290 1162668006731 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1162668006732 FeS/SAM binding site; other site 1162668006733 NifB belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme as part of...; Region: NifB; cd00852 1162668006734 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 1162668006735 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 1162668006736 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1162668006737 TPR motif; other site 1162668006738 binding surface 1162668006739 LRV protein FeS4 cluster; Region: LRV_FeS; pfam05484 1162668006740 HEAT repeats; Region: HEAT_2; pfam13646 1162668006741 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1162668006742 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1162668006743 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1162668006744 catalytic residue [active] 1162668006745 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 1162668006746 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1162668006747 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1162668006748 NifZ domain; Region: NifZ; pfam04319 1162668006749 NifU-like domain; Region: NifU; cl00484 1162668006750 NifT/FixU protein; Region: NifT; pfam06988 1162668006751 SIR2-like domain; Region: SIR2_2; pfam13289 1162668006752 ferredoxin III, nif-specific; Region: fdxN_nitrog; TIGR02936 1162668006753 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1162668006754 Nitrogen fixation protein NifW; Region: NifW; pfam03206 1162668006755 Nitrogen regulatory protein P-II; Region: P-II; pfam00543 1162668006756 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1162668006757 Nitrogen regulatory protein P-II; Region: P-II; pfam00543 1162668006758 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1162668006759 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 1162668006760 ANTAR domain; Region: ANTAR; pfam03861 1162668006761 Rop-like; Region: Rop-like; cl02247 1162668006762 homocitrate synthase NifV; Region: nifV_homocitr; TIGR02660 1162668006763 Streptomyces rubellomurinus FrbC and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_NifV; cd07939 1162668006764 active site 1162668006765 catalytic residues [active] 1162668006766 metal binding site [ion binding]; metal-binding site 1162668006767 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 [Coenzyme metabolism]; Region: ThiF; COG0476 1162668006768 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1162668006769 ATP binding site [chemical binding]; other site 1162668006770 substrate interface [chemical binding]; other site 1162668006771 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1162668006772 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1162668006773 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1162668006774 dimer interface [polypeptide binding]; other site 1162668006775 conserved gate region; other site 1162668006776 ABC-ATPase subunit interface; other site 1162668006777 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1162668006778 Walker A/P-loop; other site 1162668006779 ATP binding site [chemical binding]; other site 1162668006780 ABC transporter; Region: ABC_tran; pfam00005 1162668006781 Q-loop/lid; other site 1162668006782 ABC transporter signature motif; other site 1162668006783 Walker B; other site 1162668006784 D-loop; other site 1162668006785 H-loop/switch region; other site 1162668006786 Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740 1162668006787 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 1162668006788 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 1162668006789 hydrogenase 1 large subunit; Provisional; Region: PRK10170 1162668006790 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 1162668006791 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 1162668006792 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 1162668006793 putative substrate-binding site; other site 1162668006794 nickel binding site [ion binding]; other site 1162668006795 HupF/HypC family; Region: HupF_HypC; cl00394 1162668006796 HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809 1162668006797 coenzyme F420 hydrogenase, subunit alpha; Region: frhA; TIGR03295 1162668006798 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 1162668006799 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 1162668006800 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1162668006801 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 1162668006802 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 1162668006803 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 1162668006804 HupF/HypC family; Region: HupF_HypC; pfam01455 1162668006805 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 1162668006806 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 1162668006807 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 1162668006808 dimerization interface [polypeptide binding]; other site 1162668006809 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 1162668006810 ATP binding site [chemical binding]; other site 1162668006811 High-affinity nickel-transport protein; Region: NicO; cl00964 1162668006812 Protein of unknown function DUF45; Region: DUF45; pfam01863 1162668006813 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 1162668006814 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 1162668006815 active site 1162668006816 putative homodimer interface [polypeptide binding]; other site 1162668006817 SAM binding site [chemical binding]; other site 1162668006818 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 1162668006819 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1162668006820 S-adenosylmethionine binding site [chemical binding]; other site 1162668006821 Cobalamin biosynthesis protein CbiG [Coenzyme metabolism]; Region: CbiG; COG2073 1162668006822 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 1162668006823 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 1162668006824 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 1162668006825 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 1162668006826 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 1162668006827 active site 1162668006828 SAM binding site [chemical binding]; other site 1162668006829 homodimer interface [polypeptide binding]; other site 1162668006830 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 1162668006831 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 1162668006832 homodimer interface [polypeptide binding]; other site 1162668006833 Walker A motif; other site 1162668006834 ATP binding site [chemical binding]; other site 1162668006835 hydroxycobalamin binding site [chemical binding]; other site 1162668006836 Walker B motif; other site 1162668006837 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1162668006838 active site 1162668006839 catalytic residues [active] 1162668006840 metal binding site [ion binding]; metal-binding site 1162668006841 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1162668006842 sequence-specific DNA binding site [nucleotide binding]; other site 1162668006843 salt bridge; other site 1162668006844 Cupin domain; Region: Cupin_2; pfam07883 1162668006845 CO dehydrogenase beta subunit/acetyl-CoA synthase epsilon subunit; Region: CO_dh; pfam02552 1162668006846 CO dehydrogenase beta subunit/acetyl-CoA synthase epsilon subunit; Region: CO_dh; pfam02552 1162668006847 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1162668006848 active site 1162668006849 dimer interface [polypeptide binding]; other site 1162668006850 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1162668006851 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1162668006852 S-adenosylmethionine binding site [chemical binding]; other site 1162668006853 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1162668006854 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1162668006855 hydrogenase 4 subunit B; Validated; Region: PRK06521 1162668006856 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1162668006857 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 1162668006858 NADH dehydrogenase; Region: NADHdh; cl00469 1162668006859 Hydrogenase 4 membrane component (E) [Energy production and conversion]; Region: HyfE; cl17899 1162668006860 hydrogenase 4 subunit F; Validated; Region: PRK06458 1162668006861 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1162668006862 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; pfam00329 1162668006863 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 1162668006864 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 1162668006865 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 1162668006866 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1162668006867 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 1162668006868 Ribulose 1,5-bisphosphate carboxylase, large subunit [Carbohydrate transport and metabolism]; Region: RbcL; COG1850 1162668006869 Ribulose bisphosphate carboxylase like proteins, Rubisco-Form IV; Region: RuBisCO_IV_RLP; cd08205 1162668006870 dimer interface [polypeptide binding]; other site 1162668006871 active site 1162668006872 catalytic residue [active] 1162668006873 metal binding site [ion binding]; metal-binding site 1162668006874 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1162668006875 Transposase IS200 like; Region: Y1_Tnp; pfam01797 1162668006876 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 1162668006877 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 1162668006878 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 1162668006879 putative active site [active] 1162668006880 putative substrate binding site [chemical binding]; other site 1162668006881 putative cosubstrate binding site; other site 1162668006882 catalytic site [active] 1162668006883 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1162668006884 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1162668006885 active site 1162668006886 metal binding site [ion binding]; metal-binding site 1162668006887 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 1162668006888 Quinolinate synthetase A protein; Region: NadA; pfam02445 1162668006889 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 1162668006890 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1162668006891 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 1162668006892 tartrate dehydrogenase; Region: TTC; TIGR02089 1162668006893 2-isopropylmalate synthase; Validated; Region: PRK00915 1162668006894 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 1162668006895 active site 1162668006896 catalytic residues [active] 1162668006897 metal binding site [ion binding]; metal-binding site 1162668006898 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 1162668006899 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 1162668006900 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 1162668006901 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 1162668006902 ketol-acid reductoisomerase; Provisional; Region: PRK05479 1162668006903 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 1162668006904 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1162668006905 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 1162668006906 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1162668006907 putative valine binding site [chemical binding]; other site 1162668006908 dimer interface [polypeptide binding]; other site 1162668006909 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 1162668006910 acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118 1162668006911 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1162668006912 PYR/PP interface [polypeptide binding]; other site 1162668006913 dimer interface [polypeptide binding]; other site 1162668006914 TPP binding site [chemical binding]; other site 1162668006915 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1162668006916 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1162668006917 TPP-binding site [chemical binding]; other site 1162668006918 dimer interface [polypeptide binding]; other site