-- dump date 20140619_125507 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1111678000001 Protein involved in initiation of plasmid replication [DNA replication, recombination, and repair]; Region: COG5527 1111678000002 Initiator Replication protein; Region: Rep_3; pfam01051 1111678000003 Lactococcus lactis RepB C-terminus; Region: L_lactis_RepB_C; pfam06430 1111678000004 metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459 1111678000005 MobA/MobL family; Region: MobA_MobL; pfam03389 1111678000006 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 1111678000007 Integrase core domain; Region: rve; pfam00665 1111678000008 manganese transport protein MntH; Reviewed; Region: PRK00701 1111678000009 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1111678000010 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1111678000011 Ligand Binding Site [chemical binding]; other site 1111678000012 Integrase core domain; Region: rve; pfam00665 1111678000013 DDE domain; Region: DDE_Tnp_IS240; pfam13610 1111678000014 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; pfam02522 1111678000015 Similar to transposase; predicted non functional due to TAA stop codon 1111678000016 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 1111678000017 C4-dicarboxylate transporters of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_C4-dicarb_trans; cd09325 1111678000018 gating phenylalanine in ion channel; other site 1111678000019 Similar to transposase; predicted non-functional due to TAA stop codon 1111678000020 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 1111678000021 active site 1111678000022 catalytic residues [active] 1111678000023 6-phospho-beta-galactosidase; Provisional; Region: PRK13511 1111678000024 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 1111678000025 phosphotransferase system, lactose specific, IIC component; Region: lac_pts_IIC; TIGR00394 1111678000026 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 1111678000027 PTS_IIB_lactose: subunit IIB of enzyme II (EII) of the lactose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS) found in Firmicutes as well as Actinobacteria. In this system, EII is a lactose-specific permease with two...; Region: PTS_IIB_lactose; cd05565 1111678000028 active site 1111678000029 P-loop; other site 1111678000030 phosphorylation site [posttranslational modification] 1111678000031 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 1111678000032 methionine cluster; other site 1111678000033 active site 1111678000034 phosphorylation site [posttranslational modification] 1111678000035 metal binding site [ion binding]; metal-binding site 1111678000036 Class I aldolases; Region: Aldolase_Class_I; cl17187 1111678000037 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1111678000038 putative substrate binding site [chemical binding]; other site 1111678000039 putative ATP binding site [chemical binding]; other site 1111678000040 galactose-6-phosphate isomerase subunit LacB; Reviewed; Region: PRK08622 1111678000041 galactose-6-phosphate isomerase subunit LacA; Reviewed; Region: PRK08621 1111678000042 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1111678000043 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1111678000044 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1111678000045 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1111678000046 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1111678000047 catalytic residues [active] 1111678000048 catalytic nucleophile [active] 1111678000049 Presynaptic Site I dimer interface [polypeptide binding]; other site 1111678000050 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1111678000051 Synaptic Flat tetramer interface [polypeptide binding]; other site 1111678000052 Synaptic Site I dimer interface [polypeptide binding]; other site 1111678000053 DNA binding site [nucleotide binding] 1111678000054 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 1111678000055 DNA-binding interface [nucleotide binding]; DNA binding site 1111678000056 Family: Resolvase (PF00239); Similar to transposase; predicted non-functional due to frameshift 1111678000057 Similar to methyltransferase; predicted non-functional due to transposon insertion 1111678000058 Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164 1111678000059 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 1111678000060 active site 1111678000061 Zn binding site [ion binding]; other site 1111678000062 Similar to competence protein CoiA; predicted non-functional due to truncation 1111678000063 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 1111678000064 Integrase core domain; Region: rve; pfam00665 1111678000065 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1111678000066 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1111678000067 P-loop; other site 1111678000068 Magnesium ion binding site [ion binding]; other site 1111678000069 transport-energizing ATPase, TRC40/GET3/ArsA family; Region: GET3_arsA_TRC40; TIGR00345 1111678000070 Similar to replication protein RepB; predicted non-functional due to frameshift 1111678000071 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1111678000072 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1111678000073 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1111678000074 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1111678000075 Walker A/P-loop; other site 1111678000076 ATP binding site [chemical binding]; other site 1111678000077 Q-loop/lid; other site 1111678000078 ABC transporter signature motif; other site 1111678000079 Walker B; other site 1111678000080 D-loop; other site 1111678000081 H-loop/switch region; other site 1111678000082 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1111678000083 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1111678000084 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1111678000085 Walker A/P-loop; other site 1111678000086 ATP binding site [chemical binding]; other site 1111678000087 Q-loop/lid; other site 1111678000088 ABC transporter signature motif; other site 1111678000089 Walker B; other site 1111678000090 D-loop; other site 1111678000091 H-loop/switch region; other site 1111678000092 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1111678000093 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1111678000094 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1111678000095 dimer interface [polypeptide binding]; other site 1111678000096 conserved gate region; other site 1111678000097 putative PBP binding loops; other site 1111678000098 ABC-ATPase subunit interface; other site 1111678000099 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1111678000100 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1111678000101 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1111678000102 dimer interface [polypeptide binding]; other site 1111678000103 conserved gate region; other site 1111678000104 putative PBP binding loops; other site 1111678000105 ABC-ATPase subunit interface; other site 1111678000106 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1111678000107 The substrate binding component of an ABC-type lactococcal OppA-like transport system contains; Region: PBP2_Lactococcal_OppA_like; cd08510 1111678000108 peptide binding site [polypeptide binding]; other site 1111678000109 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 1111678000110 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 1111678000111 active site 1111678000112 Zn binding site [ion binding]; other site 1111678000113 DNA polymerase III subunit epsilon; Validated; Region: PRK06195 1111678000114 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1111678000115 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1111678000116 catalytic residues [active] 1111678000117 catalytic nucleophile [active] 1111678000118 Presynaptic Site I dimer interface [polypeptide binding]; other site 1111678000119 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1111678000120 Synaptic Flat tetramer interface [polypeptide binding]; other site 1111678000121 Synaptic Site I dimer interface [polypeptide binding]; other site 1111678000122 Alpha-acetolactate decarboxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AlsD; COG3527 1111678000123 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 1111678000124 Integrase core domain; Region: rve; pfam00665 1111678000125 Helix-turn-helix domain; Region: HTH_18; pfam12833 1111678000126 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 1111678000127 Enterocin A Immunity; Region: EntA_Immun; pfam08951 1111678000128 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1111678000129 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 1111678000130 Similar to transposase; predicted non-functional due to frameshift 1111678000131 putative protein phosphatase; Region: PHA02239 1111678000132 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 1111678000133 active site 1111678000134 metal binding site [ion binding]; metal-binding site 1111678000135 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 1111678000136 Protein involved in initiation of plasmid replication [DNA replication, recombination, and repair]; Region: COG5527 1111678000137 Initiator Replication protein; Region: Rep_3; pfam01051 1111678000138 Lactococcus lactis RepB C-terminus; Region: L_lactis_RepB_C; pfam06430 1111678000139 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 1111678000140 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 1111678000141 Clostridial hydrophobic W; Region: ChW; pfam07538 1111678000142 Staphopain peptidase C47; Region: Peptidase_C47; pfam05543 1111678000143 CHAP domain; Region: CHAP; pfam05257 1111678000144 Abi-like protein; Region: Abi_2; pfam07751 1111678000145 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 1111678000146 Integrase core domain; Region: rve; pfam00665 1111678000147 Similar to transposase; predicted non-functional due to TAA stop codon 1111678000148 Predicted metal-dependent membrane protease [General function prediction only]; Region: COG1266 1111678000149 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1111678000150 conserved cys residue [active] 1111678000151 Bacterial mobilisation protein (MobC); Region: MobC; pfam05713 1111678000152 Similar to mobilization protein MobD; predicted non-functional due to truncation 1111678000153 valyl-tRNA synthetase-like protein; Provisional; Region: PTZ00419 1111678000154 Protein involved in initiation of plasmid replication [DNA replication, recombination, and repair]; Region: COG5527 1111678000155 Initiator Replication protein; Region: Rep_3; pfam01051 1111678000156 Lactococcus lactis RepB C-terminus; Region: L_lactis_RepB_C; pfam06430 1111678000157 Fic/DOC family; Region: Fic; cl00960 1111678000158 Domain of unknown function (DUF947); Region: DUF947; pfam06102 1111678000159 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 1111678000160 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 1111678000161 Bacterial mobilisation protein (MobC); Region: MobC; pfam05713 1111678000162 Similar to integrase/recombinase; predicted non-functional due to truncation 1111678000163 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 1111678000164 Integrase core domain; Region: rve; pfam00665 1111678000165 Similar to GIY-YIG catalytic domain protein; predicted non-functional due to truncation 1111678000166 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1111678000167 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1111678000168 Similar to glycosyltransferase; predicted non-functional due to truncation 1111678000169 Domain of unknown function (DUF1919); Region: DUF1919; cl01628 1111678000170 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1111678000171 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 1111678000172 breast cancer carboxy-terminal domain; Region: BRCT; smart00292 1111678000173 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1111678000174 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1111678000175 catalytic residues [active] 1111678000176 catalytic nucleophile [active] 1111678000177 Presynaptic Site I dimer interface [polypeptide binding]; other site 1111678000178 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1111678000179 Synaptic Flat tetramer interface [polypeptide binding]; other site 1111678000180 Synaptic Site I dimer interface [polypeptide binding]; other site 1111678000181 DNA binding site [nucleotide binding] 1111678000182 Helix-turn-helix domain of Hin and related proteins; Region: HTH_Hin_like; cl17393 1111678000183 Initiator Replication protein; Region: Rep_3; pfam01051 1111678000184 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1111678000185 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1111678000186 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1111678000187 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1111678000188 P-loop; other site 1111678000189 Magnesium ion binding site [ion binding]; other site 1111678000190 ParB-like nuclease domain; Region: ParBc; pfam02195 1111678000191 DNA polymerase IV; Reviewed; Region: PRK03103 1111678000192 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 1111678000193 active site 1111678000194 DNA binding site [nucleotide binding] 1111678000195 Similar to type I HsdR; predicted non-functional due to truncation 1111678000196 Similar to Transposase; predicted non-functional due to truncation 1111678000197 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 1111678000198 Integrase core domain; Region: rve; pfam00665 1111678000199 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1111678000200 Glutamine amidotransferase class-I; Region: GATase; pfam00117 1111678000201 glutamine binding [chemical binding]; other site 1111678000202 catalytic triad [active] 1111678000203 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 1111678000204 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1111678000205 aminodeoxychorismate synthase, component I, bacterial clade; Region: pabB; TIGR00553 1111678000206 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1111678000207 substrate-cofactor binding pocket; other site 1111678000208 homodimer interface [polypeptide binding]; other site 1111678000209 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 1111678000210 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1111678000211 catalytic residue [active] 1111678000212 Similar to replication protien; predicted non-functional due to truncation 1111678000213 Similar to GNAT family acetyltransferase; predicted non-functional due to truncation 1111678000214 Similar to integrase/recombinase; predicted non-functional due to truncation 1111678000215 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1111678000216 Helix-turn-helix domain; Region: HTH_18; pfam12833 1111678000217 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 1111678000218 Similar to transposase; predicted non-functional due to truncation 1111678000219 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1111678000220 Transposase; Region: HTH_Tnp_1; pfam01527 1111678000221 HTH-like domain; Region: HTH_21; pfam13276 1111678000222 Integrase core domain; Region: rve; pfam00665 1111678000223 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 1111678000224 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1111678000225 Walker A motif; other site 1111678000226 ATP binding site [chemical binding]; other site 1111678000227 Walker B motif; other site 1111678000228 arginine finger; other site 1111678000229 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1111678000230 Integrase core domain; Region: rve; pfam00665 1111678000231 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1111678000232 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1111678000233 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1111678000234 P-loop; other site 1111678000235 Magnesium ion binding site [ion binding]; other site 1111678000236 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1111678000237 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1111678000238 catalytic residues [active] 1111678000239 catalytic nucleophile [active] 1111678000240 Presynaptic Site I dimer interface [polypeptide binding]; other site 1111678000241 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1111678000242 Synaptic Flat tetramer interface [polypeptide binding]; other site 1111678000243 Synaptic Site I dimer interface [polypeptide binding]; other site 1111678000244 DNA binding site [nucleotide binding] 1111678000245 Helix-turn-helix domain of Hin and related proteins; Region: HTH_Hin_like; cl17393 1111678000246 DNA-binding interface [nucleotide binding]; DNA binding site 1111678000247 DNA polymerase IV; Reviewed; Region: PRK03103 1111678000248 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 1111678000249 active site 1111678000250 DNA binding site [nucleotide binding] 1111678000251 Restriction endonuclease; Region: Mrr_cat; cl19295 1111678000252 ABC-type bacteriocin transporter; Region: bacteriocin_ABC; TIGR01193 1111678000253 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418 1111678000254 putative active site [active] 1111678000255 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1111678000256 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1111678000257 Walker A/P-loop; other site 1111678000258 ATP binding site [chemical binding]; other site 1111678000259 Q-loop/lid; other site 1111678000260 ABC transporter signature motif; other site 1111678000261 Walker B; other site 1111678000262 D-loop; other site 1111678000263 H-loop/switch region; other site 1111678000264 bacteriocin secretion accessory protein; Region: bacteriocin_acc; TIGR01000 1111678000265 HlyD family secretion protein; Region: HlyD_3; pfam13437 1111678000266 Lactococcin-like family; Region: Lactococcin; pfam04369 1111678000267 Enterocin A Immunity; Region: EntA_Immun; pfam08951 1111678000268 Lactococcin-like family; Region: Lactococcin; pfam04369 1111678000269 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1111678000270 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 1111678000271 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1111678000272 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1111678000273 COMC family; Region: ComC; pfam03047 1111678000274 Lactococcin-like family; Region: Lactococcin; pfam04369 1111678000275 bacteriocin secretion accessory protein; Region: bacteriocin_acc; TIGR01000 1111678000276 HlyD family secretion protein; Region: HlyD_3; pfam13437 1111678000277 Family: ABC_tran (PF00005); Similar to lactococcin A ABC transporter ATP binding and permease protein; predicted non-functional due to TAA stop codon 1111678000278 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1111678000279 active site 1111678000280 ATP binding site [chemical binding]; other site 1111678000281 substrate binding site [chemical binding]; other site 1111678000282 activation loop (A-loop); other site 1111678000283 multiple promoter invertase; Provisional; Region: mpi; PRK13413 1111678000284 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1111678000285 catalytic residues [active] 1111678000286 catalytic nucleophile [active] 1111678000287 Presynaptic Site I dimer interface [polypeptide binding]; other site 1111678000288 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1111678000289 Synaptic Flat tetramer interface [polypeptide binding]; other site 1111678000290 Synaptic Site I dimer interface [polypeptide binding]; other site 1111678000291 DNA binding site [nucleotide binding] 1111678000292 Helix-turn-helix domain of Hin and related proteins; Region: HTH_Hin_like; cl17393 1111678000293 DNA-binding interface [nucleotide binding]; DNA binding site 1111678000294 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl19151 1111678000295 Similar to relaxase/nobilization nuclease domain-containing protein MobD; predicted non-functional due to TAA stop codon 1111678000296 Transposase; Region: HTH_Tnp_1; pfam01527 1111678000297 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1111678000298 putative transposase OrfB; Reviewed; Region: PHA02517 1111678000299 HTH-like domain; Region: HTH_21; pfam13276 1111678000300 Integrase core domain; Region: rve; pfam00665 1111678000301 Integrase core domain; Region: rve_3; pfam13683 1111678000302 Similar to transcriptional regulator; predicted non-functional due to truncation 1111678000303 Protein involved in initiation of plasmid replication [DNA replication, recombination, and repair]; Region: COG5527 1111678000304 Initiator Replication protein; Region: Rep_3; pfam01051 1111678000305 Lactococcus lactis RepB C-terminus; Region: L_lactis_RepB_C; pfam06430 1111678000306 HTH DNA binding domain; Region: HTH_10; pfam04967 1111678000307 Cobalamin biosynthesis protein CobT; Region: CobT; pfam06213 1111678000308 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 1111678000309 Integrase core domain; Region: rve; pfam00665 1111678000310 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 1111678000311 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 1111678000312 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1111678000313 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1111678000314 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1111678000315 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1111678000316 Similar to serine/threonine protein kinase; predicted non-functional due to truncation 1111678000317 multiple promoter invertase; Provisional; Region: mpi; PRK13413 1111678000318 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1111678000319 catalytic residues [active] 1111678000320 catalytic nucleophile [active] 1111678000321 Presynaptic Site I dimer interface [polypeptide binding]; other site 1111678000322 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1111678000323 Synaptic Flat tetramer interface [polypeptide binding]; other site 1111678000324 Synaptic Site I dimer interface [polypeptide binding]; other site 1111678000325 Helix-turn-helix domain of Hin and related proteins; Region: HTH_Hin_like; cd00569 1111678000326 DNA-binding interface [nucleotide binding]; DNA binding site 1111678000327 Bacterial mobilisation protein (MobC); Region: MobC; pfam05713 1111678000328 Protein involved in initiation of plasmid replication [DNA replication, recombination, and repair]; Region: COG5527 1111678000329 Initiator Replication protein; Region: Rep_3; pfam01051 1111678000330 Lactococcus lactis RepB C-terminus; Region: L_lactis_RepB_C; pfam06430 1111678000331 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1111678000332 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1111678000333 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 1111678000334 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1111678000336 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 1111678000337 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 1111678000338 Cl binding site [ion binding]; other site 1111678000339 oligomer interface [polypeptide binding]; other site 1111678000340 Protein involved in initiation of plasmid replication [DNA replication, recombination, and repair]; Region: COG5527 1111678000341 Initiator Replication protein; Region: Rep_3; pfam01051 1111678000342 Lactococcus lactis RepB C-terminus; Region: L_lactis_RepB_C; pfam06430 1111678000343 Transcriptional regulator; Region: Rrf2; cl17282 1111678000344 Protein of unknown function, DUF536; Region: DUF536; pfam04394 1111678000345 Similar to HsdS specificity subunit type I R/M; predicted non-functional due to truncation 1111678000346 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1111678000347 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 1111678000348 active site 1111678000349 metal binding site [ion binding]; metal-binding site 1111678000350 Bacterial mobilisation protein (MobC); Region: MobC; pfam05713 1111678000351 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 1111678000352 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1111678000353 Walker A motif; other site 1111678000354 ATP binding site [chemical binding]; other site 1111678000355 Walker B motif; other site 1111678000356 arginine finger; other site 1111678000357 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1111678000358 DnaA box-binding interface [nucleotide binding]; other site 1111678000359 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1111678000360 DNA polymerase III beta subunit; Region: POL3Bc; smart00480 1111678000361 putative DNA binding surface [nucleotide binding]; other site 1111678000362 dimer interface [polypeptide binding]; other site 1111678000363 beta-clamp/clamp loader binding surface; other site 1111678000364 beta-clamp/translesion DNA polymerase binding surface; other site 1111678000365 ATP-dependent nuclease, subunit B [DNA replication, recombination, and repair]; Region: AddB; COG3857 1111678000366 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1111678000367 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 1111678000368 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1111678000369 Part of AAA domain; Region: AAA_19; pfam13245 1111678000370 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; cl19402 1111678000371 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 1111678000372 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1111678000373 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1111678000374 non-specific DNA binding site [nucleotide binding]; other site 1111678000375 salt bridge; other site 1111678000376 sequence-specific DNA binding site [nucleotide binding]; other site 1111678000377 Protein of unknown function (DUF1700); Region: DUF1700; pfam08006 1111678000378 GTP-binding protein YchF; Reviewed; Region: PRK09601 1111678000379 YchF GTPase; Region: YchF; cd01900 1111678000380 G1 box; other site 1111678000381 GTP/Mg2+ binding site [chemical binding]; other site 1111678000382 Switch I region; other site 1111678000383 G2 box; other site 1111678000384 Switch II region; other site 1111678000385 G3 box; other site 1111678000386 G4 box; other site 1111678000387 G5 box; other site 1111678000388 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1111678000389 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1111678000390 non-specific DNA binding site [nucleotide binding]; other site 1111678000391 salt bridge; other site 1111678000392 sequence-specific DNA binding site [nucleotide binding]; other site 1111678000393 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1111678000394 putative active site [active] 1111678000395 catalytic residue [active] 1111678000396 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 1111678000397 Bifunctional transglycosylase second domain; Region: UB2H; pfam14814 1111678000398 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 1111678000399 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1111678000400 ATP binding site [chemical binding]; other site 1111678000401 putative Mg++ binding site [ion binding]; other site 1111678000402 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1111678000403 nucleotide binding region [chemical binding]; other site 1111678000404 ATP-binding site [chemical binding]; other site 1111678000405 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 1111678000406 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1111678000407 RNA binding surface [nucleotide binding]; other site 1111678000408 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 1111678000409 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1111678000410 RNA binding site [nucleotide binding]; other site 1111678000411 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 1111678000412 SH3-like domain; Region: SH3_8; pfam13457 1111678000413 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 1111678000414 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 1111678000415 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1111678000416 Ligand Binding Site [chemical binding]; other site 1111678000417 TilS substrate C-terminal domain; Region: TilS_C; smart00977 1111678000418 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1111678000419 active site 1111678000420 FtsH Extracellular; Region: FtsH_ext; pfam06480 1111678000421 ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465 1111678000422 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1111678000423 Walker A motif; other site 1111678000424 ATP binding site [chemical binding]; other site 1111678000425 Walker B motif; other site 1111678000426 arginine finger; other site 1111678000427 Peptidase family M41; Region: Peptidase_M41; pfam01434 1111678000428 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 1111678000429 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 1111678000430 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 1111678000431 active site 1111678000432 P-loop; other site 1111678000433 phosphorylation site [posttranslational modification] 1111678000434 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 1111678000435 active site 1111678000436 P-loop; other site 1111678000437 phosphorylation site [posttranslational modification] 1111678000438 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1111678000439 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 1111678000440 PRD domain; Region: PRD; pfam00874 1111678000441 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 1111678000442 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1111678000443 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1111678000444 Walker A motif; other site 1111678000445 ATP binding site [chemical binding]; other site 1111678000446 Walker B motif; other site 1111678000447 arginine finger; other site 1111678000448 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1111678000449 Integrase core domain; Region: rve; pfam00665 1111678000450 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1111678000451 active site 1111678000452 phosphorylation site [posttranslational modification] 1111678000453 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 1111678000454 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1111678000455 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1111678000456 Predicted membrane protein [Function unknown]; Region: XynA; COG2314 1111678000457 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1111678000458 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1111678000459 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1111678000460 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1111678000461 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1111678000462 Coenzyme A binding pocket [chemical binding]; other site 1111678000463 aminotransferase A; Validated; Region: PRK07683 1111678000464 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1111678000465 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1111678000466 homodimer interface [polypeptide binding]; other site 1111678000467 catalytic residue [active] 1111678000468 Recombination protein O N terminal; Region: RecO_N; pfam11967 1111678000469 Recombinational DNA repair protein (RecF pathway) [DNA replication, recombination, and repair]; Region: RecO; COG1381 1111678000470 Recombination protein O C terminal; Region: RecO_C; pfam02565 1111678000471 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 1111678000472 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 1111678000473 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1111678000474 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 1111678000475 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1111678000476 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 1111678000477 E3 interaction surface; other site 1111678000478 lipoyl attachment site [posttranslational modification]; other site 1111678000479 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1111678000480 E3 interaction surface; other site 1111678000481 lipoyl attachment site [posttranslational modification]; other site 1111678000482 e3 binding domain; Region: E3_binding; pfam02817 1111678000483 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1111678000484 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1111678000485 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1111678000486 alpha subunit interface [polypeptide binding]; other site 1111678000487 TPP binding site [chemical binding]; other site 1111678000488 heterodimer interface [polypeptide binding]; other site 1111678000489 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1111678000490 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 1111678000491 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1111678000492 tetramer interface [polypeptide binding]; other site 1111678000493 TPP-binding site [chemical binding]; other site 1111678000494 heterodimer interface [polypeptide binding]; other site 1111678000495 phosphorylation loop region [posttranslational modification] 1111678000496 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 1111678000497 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1111678000498 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 1111678000499 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1111678000500 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 1111678000501 active site 1111678000502 catalytic site [active] 1111678000503 metal binding site [ion binding]; metal-binding site 1111678000504 dimer interface [polypeptide binding]; other site 1111678000505 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 1111678000506 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1111678000507 Zn2+ binding site [ion binding]; other site 1111678000508 Mg2+ binding site [ion binding]; other site 1111678000509 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1111678000510 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1111678000511 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1111678000512 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1111678000513 active site 1111678000514 HIGH motif; other site 1111678000515 dimer interface [polypeptide binding]; other site 1111678000516 KMSKS motif; other site 1111678000517 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 1111678000518 Amino acid permease; Region: AA_permease_2; pfam13520 1111678000519 putative phosphate acyltransferase; Provisional; Region: PRK05331 1111678000520 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1111678000521 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1111678000522 active site 1111678000523 motif I; other site 1111678000524 motif II; other site 1111678000525 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 1111678000526 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 1111678000527 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1111678000528 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1111678000529 ABC transporter; Region: ABC_tran_2; pfam12848 1111678000530 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1111678000531 yiaA/B two helix domain; Region: YiaAB; pfam05360 1111678000532 short chain dehydrogenase; Validated; Region: PRK06182 1111678000533 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1111678000534 NADP binding site [chemical binding]; other site 1111678000535 active site 1111678000536 steroid binding site; other site 1111678000537 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1111678000538 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1111678000539 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1111678000540 homodimer interface [polypeptide binding]; other site 1111678000541 substrate-cofactor binding pocket; other site 1111678000542 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1111678000543 catalytic residue [active] 1111678000544 short chain dehydrogenase; Validated; Region: PRK06182 1111678000545 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1111678000546 NADP binding site [chemical binding]; other site 1111678000547 active site 1111678000548 steroid binding site; other site 1111678000549 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1111678000550 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1111678000551 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1111678000552 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1111678000553 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 1111678000554 Int/Topo IB signature motif; other site 1111678000555 Plasmid replication protein; Region: Rep_2; pfam01719 1111678000556 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 1111678000557 Walker A/P-loop; other site 1111678000558 ATP binding site [chemical binding]; other site 1111678000559 Q-loop/lid; other site 1111678000560 ABC transporter signature motif; other site 1111678000561 Walker B; other site 1111678000562 D-loop; other site 1111678000563 H-loop/switch region; other site 1111678000564 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1111678000565 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1111678000566 non-specific DNA binding site [nucleotide binding]; other site 1111678000567 salt bridge; other site 1111678000568 sequence-specific DNA binding site [nucleotide binding]; other site 1111678000569 Protein of unknown function (DUF4238); Region: DUF4238; pfam14022 1111678000570 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1111678000571 non-specific DNA binding site [nucleotide binding]; other site 1111678000572 salt bridge; other site 1111678000573 DNA cytosine methylase; Provisional; Region: PRK10458 1111678000574 sequence-specific DNA binding site [nucleotide binding]; other site 1111678000575 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1111678000576 cofactor binding site; other site 1111678000577 DNA binding site [nucleotide binding] 1111678000578 substrate interaction site [chemical binding]; other site 1111678000579 LlaMI restriction endonuclease; Region: RE_LlaMI; pfam09562 1111678000580 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1111678000581 cofactor binding site; other site 1111678000582 DNA binding site [nucleotide binding] 1111678000583 substrate interaction site [chemical binding]; other site 1111678000584 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1111678000585 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 1111678000586 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 1111678000587 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1111678000588 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1111678000589 Similar to Uncharacterized membrane-anchored protein conserved in bacteria; predicted to be none functional due to G deletion leading to frame shift 1111678000590 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 1111678000591 ParB-like nuclease domain; Region: ParBc; pfam02195 1111678000592 KorB domain; Region: KorB; pfam08535 1111678000593 recombination factor protein RarA; Reviewed; Region: PRK13342 1111678000594 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1111678000595 Walker A motif; other site 1111678000596 ATP binding site [chemical binding]; other site 1111678000597 Walker B motif; other site 1111678000598 arginine finger; other site 1111678000599 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1111678000600 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1111678000601 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1111678000602 Coenzyme A binding pocket [chemical binding]; other site 1111678000603 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1111678000604 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1111678000605 Protein of unknown function (DUF3013); Region: DUF3013; pfam11217 1111678000606 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1111678000607 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1111678000608 Walker A/P-loop; other site 1111678000609 ATP binding site [chemical binding]; other site 1111678000610 Q-loop/lid; other site 1111678000611 ABC transporter signature motif; other site 1111678000612 Walker B; other site 1111678000613 D-loop; other site 1111678000614 H-loop/switch region; other site 1111678000615 ABC transporter; Region: ABC_tran_2; pfam12848 1111678000616 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1111678000617 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 1111678000618 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1111678000619 S-adenosylmethionine binding site [chemical binding]; other site 1111678000620 Domain of unknown function (DUF1905); Region: DUF1905; pfam08922 1111678000621 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 1111678000622 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 1111678000623 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1111678000624 S-adenosylmethionine binding site [chemical binding]; other site 1111678000625 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 1111678000626 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 1111678000627 putative active site [active] 1111678000628 putative metal binding site [ion binding]; other site 1111678000629 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1111678000630 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1111678000631 Zn2+ binding site [ion binding]; other site 1111678000632 Mg2+ binding site [ion binding]; other site 1111678000633 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1111678000634 synthetase active site [active] 1111678000635 NTP binding site [chemical binding]; other site 1111678000636 metal binding site [ion binding]; metal-binding site 1111678000637 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1111678000638 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1111678000639 Similar to family 2 glycosyltransferase; predicted to be non-fucntional due to C to T conversion leading to TGA stop codon 1111678000640 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 1111678000641 putative active site [active] 1111678000642 dimerization interface [polypeptide binding]; other site 1111678000643 putative tRNAtyr binding site [nucleotide binding]; other site 1111678000644 Predicted integral membrane protein [Function unknown]; Region: COG3548 1111678000645 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 1111678000646 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1111678000647 amino acid transporter; Region: 2A0306; TIGR00909 1111678000648 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 1111678000649 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1111678000650 putative acyl-acceptor binding pocket; other site 1111678000651 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1111678000652 MarR family; Region: MarR_2; pfam12802 1111678000653 Acyl carrier protein phosphodiesterase [Lipid metabolism]; Region: AcpD; COG1182 1111678000654 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 1111678000655 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1111678000656 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1111678000657 nucleotide binding region [chemical binding]; other site 1111678000658 ATP-binding site [chemical binding]; other site 1111678000659 SecA Wing and Scaffold domain; Region: SecA_SW; pfam07516 1111678000660 SEC-C motif; Region: SEC-C; pfam02810 1111678000661 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroG; COG0722 1111678000662 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1111678000663 dimerization domain swap beta strand [polypeptide binding]; other site 1111678000664 regulatory protein interface [polypeptide binding]; other site 1111678000665 active site 1111678000666 regulatory phosphorylation site [posttranslational modification]; other site 1111678000667 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 1111678000668 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1111678000669 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1111678000670 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1111678000671 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG0718 1111678000672 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 1111678000673 Putative lysophospholipase; Region: Hydrolase_4; cl19140 1111678000674 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 1111678000675 Similar to glycosylhydrolase; predicted non-functional due to A to T conversion leading to TAA stop codon 1111678000676 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1111678000677 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1111678000678 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1111678000679 putative substrate translocation pore; other site 1111678000680 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1111678000681 Transposase; Region: HTH_Tnp_1; pfam01527 1111678000682 putative transposase OrfB; Reviewed; Region: PHA02517 1111678000683 HTH-like domain; Region: HTH_21; pfam13276 1111678000684 Integrase core domain; Region: rve; pfam00665 1111678000685 Integrase core domain; Region: rve_3; pfam13683 1111678000686 Similar to sensor protein kinase; predicted to be non-functional due to transposon insertion leading to N terminal truncation 1111678000687 Similar to membrane permease; predicted non-functional due to transposon insertion 1111678000688 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1111678000689 Integrase core domain; Region: rve; pfam00665 1111678000690 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1111678000691 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1111678000692 Walker A motif; other site 1111678000693 ATP binding site [chemical binding]; other site 1111678000694 Walker B motif; other site 1111678000695 arginine finger; other site 1111678000696 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 1111678000697 ANP binding site [chemical binding]; other site 1111678000698 Substrate Binding Site II [chemical binding]; other site 1111678000699 Substrate Binding Site I [chemical binding]; other site 1111678000700 argininosuccinate lyase; Provisional; Region: PRK00855 1111678000701 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1111678000702 active sites [active] 1111678000703 tetramer interface [polypeptide binding]; other site 1111678000704 drug efflux system protein MdtG; Provisional; Region: PRK09874 1111678000705 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1111678000706 putative substrate translocation pore; other site 1111678000707 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1111678000708 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1111678000709 WHG domain; Region: WHG; pfam13305 1111678000710 ribonuclease P; Reviewed; Region: rnpA; PRK00499 1111678000711 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 1111678000712 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 1111678000713 Jag N-terminus; Region: Jag_N; pfam14804 1111678000714 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 1111678000715 G-X-X-G motif; other site 1111678000716 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 1111678000717 RxxxH motif; other site 1111678000718 Ribosomal protein L34 [Translation, ribosomal structure and biogenesis]; Region: RpmH; COG0230 1111678000719 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1111678000720 active site 1111678000721 catalytic tetrad [active] 1111678000722 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1111678000723 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1111678000724 non-specific DNA binding site [nucleotide binding]; other site 1111678000725 salt bridge; other site 1111678000726 sequence-specific DNA binding site [nucleotide binding]; other site 1111678000727 Predicted metal-dependent membrane protease [General function prediction only]; Region: COG1266 1111678000728 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4472 1111678000729 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 1111678000730 hypothetical protein; Provisional; Region: PRK13678 1111678000731 Predicted integral membrane protein [Function unknown]; Region: COG3548 1111678000732 Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967 1111678000733 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1111678000734 NAD(P) binding site [chemical binding]; other site 1111678000735 active site 1111678000736 Uncharacterized protein conserved in bacteria (DUF2316); Region: DUF2316; pfam10078 1111678000737 Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967 1111678000738 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1111678000739 NAD(P) binding site [chemical binding]; other site 1111678000740 active site 1111678000741 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1111678000742 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1111678000743 putative DNA binding site [nucleotide binding]; other site 1111678000744 putative Zn2+ binding site [ion binding]; other site 1111678000745 glycogen branching enzyme; Provisional; Region: PRK12313 1111678000746 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 1111678000747 Alpha amylase catalytic domain found in bacterial and eukaryotic branching enzymes; Region: AmyAc_bac_euk_BE; cd11321 1111678000748 active site 1111678000749 catalytic site [active] 1111678000750 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 1111678000751 Similar to nitroreductase; predicted to be non-functional due to C deletion leading to frameshfit 1111678000752 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1111678000753 Transposase; Region: HTH_Tnp_1; pfam01527 1111678000754 putative transposase OrfB; Reviewed; Region: PHA02517 1111678000755 HTH-like domain; Region: HTH_21; pfam13276 1111678000756 Integrase core domain; Region: rve; pfam00665 1111678000757 Integrase core domain; Region: rve_3; pfam13683 1111678000758 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1111678000759 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1111678000760 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 1111678000761 Collagen binding domain; Region: Collagen_bind; pfam05737 1111678000762 Collagen binding domain; Region: Collagen_bind; pfam05737 1111678000763 Collagen binding domain; Region: Collagen_bind; pfam05737 1111678000764 Collagen binding domain; Region: Collagen_bind; pfam05737 1111678000765 Cna protein B-type domain; Region: Cna_B; pfam05738 1111678000766 Cna protein B-type domain; Region: Cna_B; pfam05738 1111678000767 Cna protein B-type domain; Region: Cna_B; pfam05738 1111678000768 Cna protein B-type domain; Region: Cna_B; pfam05738 1111678000769 Cna protein B-type domain; Region: Cna_B; pfam05738 1111678000770 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 1111678000771 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 1111678000772 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 1111678000773 WxL domain surface cell wall-binding; Region: WxL; pfam13731 1111678000774 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1111678000775 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1111678000776 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1111678000777 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1111678000778 non-specific DNA binding site [nucleotide binding]; other site 1111678000779 salt bridge; other site 1111678000780 sequence-specific DNA binding site [nucleotide binding]; other site 1111678000781 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 1111678000782 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 1111678000783 Protein of unknown function (DUF975); Region: DUF975; cl10504 1111678000784 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1111678000785 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1111678000786 putative substrate translocation pore; other site 1111678000787 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 1111678000788 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 1111678000789 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl19158 1111678000790 aminotransferase AlaT; Validated; Region: PRK09265 1111678000791 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1111678000792 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1111678000793 homodimer interface [polypeptide binding]; other site 1111678000794 catalytic residue [active] 1111678000795 Pleiotropic transcriptional repressor [Transcription]; Region: CodY; COG4465 1111678000796 CodY GAF-like domain; Region: CodY; pfam06018 1111678000797 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 1111678000798 Asp-tRNAAsn/Glu-tRNAGln amidotransferase C subunit [Translation, ribosomal structure and biogenesis]; Region: GatC; COG0721 1111678000799 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 1111678000800 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 1111678000801 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 1111678000802 GatB domain; Region: GatB_Yqey; pfam02637 1111678000803 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl18951 1111678000804 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 1111678000805 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1111678000806 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1111678000807 DNA-binding site [nucleotide binding]; DNA binding site 1111678000808 RNA-binding motif; other site 1111678000809 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 1111678000810 Rhomboid family; Region: Rhomboid; pfam01694 1111678000811 Domain of unknown function (DUF3284); Region: DUF3284; pfam11687 1111678000812 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1111678000813 active site 1111678000814 metal binding site [ion binding]; metal-binding site 1111678000815 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 1111678000816 Sterol carrier protein domain; Region: SCP2_2; pfam13530 1111678000817 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 1111678000818 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 1111678000819 UbiA family of prenyltransferases (PTases); Region: PT_UbiA; cl00337 1111678000820 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1111678000821 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 1111678000822 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1111678000823 trimer interface [polypeptide binding]; other site 1111678000824 active site 1111678000825 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1111678000826 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 1111678000827 active site 1111678000828 metal binding site [ion binding]; metal-binding site 1111678000829 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1111678000830 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4470 1111678000831 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 1111678000832 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1111678000833 FeS/SAM binding site; other site 1111678000834 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 1111678000835 dimer interface [polypeptide binding]; other site 1111678000836 FMN binding site [chemical binding]; other site 1111678000837 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1111678000838 substrate binding pocket [chemical binding]; other site 1111678000839 chain length determination region; other site 1111678000840 substrate-Mg2+ binding site; other site 1111678000841 catalytic residues [active] 1111678000842 aspartate-rich region 1; other site 1111678000843 active site lid residues [active] 1111678000844 aspartate-rich region 2; other site 1111678000845 1,4-Dihydroxy-2-naphthoate octaprenyltransferase; Region: PT_UbiA_UBIAD1; cd13962 1111678000846 putative active site [active] 1111678000847 CAAX protease self-immunity; Region: Abi; pfam02517 1111678000848 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 1111678000849 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 1111678000850 G1 box; other site 1111678000851 GTP/Mg2+ binding site [chemical binding]; other site 1111678000852 Switch I region; other site 1111678000853 G2 box; other site 1111678000854 G3 box; other site 1111678000855 Switch II region; other site 1111678000856 G4 box; other site 1111678000857 G5 box; other site 1111678000858 Nucleoside recognition; Region: Gate; pfam07670 1111678000859 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 1111678000860 Nucleoside recognition; Region: Gate; pfam07670 1111678000861 FeoA domain; Region: FeoA; pfam04023 1111678000862 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 1111678000863 methionine sulfoxide reductase B; Provisional; Region: PRK00222 1111678000864 Predicted kinase related to dihydroxyacetone kinase [General function prediction only]; Region: COG1461 1111678000865 DAK2 domain; Region: Dak2; pfam02734 1111678000866 Dihydroxyacetone kinase family; Region: Dak1_2; pfam13684 1111678000867 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 1111678000868 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1111678000869 Uncharacterized membrane-bound protein conserved in bacteria [Function unknown]; Region: COG4858 1111678000870 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 1111678000871 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 1111678000872 substrate binding site; other site 1111678000873 tetramer interface; other site 1111678000874 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 1111678000875 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 1111678000876 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1111678000877 NAD binding site [chemical binding]; other site 1111678000878 substrate binding site [chemical binding]; other site 1111678000879 homodimer interface [polypeptide binding]; other site 1111678000880 active site 1111678000881 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 1111678000882 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 1111678000883 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 1111678000884 NADP binding site [chemical binding]; other site 1111678000885 active site 1111678000886 putative substrate binding site [chemical binding]; other site 1111678000887 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1111678000888 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_6; cd04955 1111678000889 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196 1111678000890 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1111678000891 Probable Catalytic site; other site 1111678000892 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 1111678000893 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 1111678000894 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 1111678000895 Walker A/P-loop; other site 1111678000896 ATP binding site [chemical binding]; other site 1111678000897 Q-loop/lid; other site 1111678000898 ABC transporter signature motif; other site 1111678000899 Walker B; other site 1111678000900 D-loop; other site 1111678000901 H-loop/switch region; other site 1111678000902 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl19158 1111678000903 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1111678000904 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1111678000905 active site 1111678000906 Rhamnan synthesis protein F; Region: RgpF; pfam05045 1111678000907 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1111678000908 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1111678000909 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl19158 1111678000910 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1111678000911 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1111678000912 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1111678000913 active site 1111678000914 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1111678000915 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1111678000916 Ligand binding site; other site 1111678000917 Putative Catalytic site; other site 1111678000918 DXD motif; other site 1111678000919 Uncharacterized conserved protein (DUF2304); Region: DUF2304; cl01034 1111678000920 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1111678000921 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1111678000922 active site 1111678000923 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1111678000924 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1111678000925 active site 1111678000926 putative glycosyl transferase; Provisional; Region: PRK10073 1111678000927 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1111678000928 active site 1111678000929 LicD family; Region: LicD; pfam04991 1111678000930 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 1111678000931 colanic acid exporter; Provisional; Region: PRK10459 1111678000932 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 1111678000933 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 1111678000934 Clostridial hydrophobic W; Region: ChW; pfam07538 1111678000935 Clostridial hydrophobic W; Region: ChW; pfam07538 1111678000936 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 1111678000937 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 1111678000938 Clostridial hydrophobic W; Region: ChW; pfam07538 1111678000939 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1111678000940 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 1111678000941 active site 1111678000942 catalytic site [active] 1111678000943 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1111678000944 active site 1111678000945 nucleotide binding site [chemical binding]; other site 1111678000946 HIGH motif; other site 1111678000947 KMSKS motif; other site 1111678000948 Similar to glycoside hydrolase; putative non-functional due to transposon insertion 1111678000949 Similar to Tn982 Transposase; predicted non-functional due to frameshift 1111678000950 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 1111678000951 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1111678000952 active site 1111678000953 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 1111678000954 GTPase YqeH; Provisional; Region: PRK13796 1111678000955 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 1111678000956 GTP/Mg2+ binding site [chemical binding]; other site 1111678000957 G4 box; other site 1111678000958 G5 box; other site 1111678000959 G1 box; other site 1111678000960 Switch I region; other site 1111678000961 G2 box; other site 1111678000962 G3 box; other site 1111678000963 Switch II region; other site 1111678000964 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688 1111678000965 nudix motif; other site 1111678000966 GTPases [General function prediction only]; Region: HflX; COG2262 1111678000967 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1111678000968 HflX GTPase family; Region: HflX; cd01878 1111678000969 G1 box; other site 1111678000970 GTP/Mg2+ binding site [chemical binding]; other site 1111678000971 Switch I region; other site 1111678000972 G2 box; other site 1111678000973 G3 box; other site 1111678000974 Switch II region; other site 1111678000975 G4 box; other site 1111678000976 G5 box; other site 1111678000977 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 1111678000978 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1111678000979 active site 1111678000980 (T/H)XGH motif; other site 1111678000981 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1111678000982 Zn2+ binding site [ion binding]; other site 1111678000983 Mg2+ binding site [ion binding]; other site 1111678000984 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1111678000985 Coenzyme A binding pocket [chemical binding]; other site 1111678000986 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 1111678000987 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1111678000988 S-adenosylmethionine binding site [chemical binding]; other site 1111678000989 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673 1111678000990 hypothetical protein; Provisional; Region: PRK12378 1111678000991 Uncharacterized conserved protein [Function unknown]; Region: COG4832 1111678000992 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 1111678000993 ligand binding site [chemical binding]; other site 1111678000994 active site 1111678000995 UGI interface [polypeptide binding]; other site 1111678000996 catalytic site [active] 1111678000997 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1111678000998 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1111678000999 NAD(P) binding site [chemical binding]; other site 1111678001000 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 1111678001001 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1111678001002 Similar to drug resistance transporter, EmrB/QacA family; predicted to be non-functional due to frameshift 1111678001003 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1111678001004 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 1111678001005 DNA binding residues [nucleotide binding] 1111678001006 putative dimer interface [polypeptide binding]; other site 1111678001007 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 1111678001008 Similar to cell-wall-anchored protein SasA (LPXTG motif); predicted non-functional due to transposon insertion 1111678001009 putative transposase OrfB; Reviewed; Region: PHA02517 1111678001010 HTH-like domain; Region: HTH_21; pfam13276 1111678001011 Integrase core domain; Region: rve; pfam00665 1111678001012 Integrase core domain; Region: rve_3; pfam13683 1111678001013 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1111678001014 Transposase; Region: HTH_Tnp_1; pfam01527 1111678001015 phosphoglycerate kinase; Provisional; Region: pgk; PRK00073 1111678001016 substrate binding site [chemical binding]; other site 1111678001017 hinge regions; other site 1111678001018 ADP binding site [chemical binding]; other site 1111678001019 catalytic site [active] 1111678001020 DhaKLM operon coactivator DhaQ; Provisional; Region: PRK14483 1111678001021 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 1111678001022 Bacterial regulatory proteins, tetR family; Region: TetR_N; cl19382 1111678001023 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 1111678001024 dihydroxyacetone kinase, phosphoprotein-dependent, L subunit; Region: dha_L_ycgS; TIGR02365 1111678001025 phosphotransferase mannnose-specific family component IIA; Provisional; Region: PRK14484 1111678001026 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 1111678001027 amphipathic channel; other site 1111678001028 Asn-Pro-Ala signature motifs; other site 1111678001029 Dipeptidase [Amino acid transport and metabolism]; Region: PepD; COG4690 1111678001030 ABC transporter, ATP-binding protein, predicted non-functional due to C to T conversion leading to TAA stop codon 1111678001031 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1111678001032 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1111678001033 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 1111678001034 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 1111678001035 putative RNA binding site [nucleotide binding]; other site 1111678001036 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1111678001037 Similar to fructose-1,6-bisphosphatase; non-functional due to T to G conversion leading to TAG stop codon 1111678001038 HI0933-like protein; Region: HI0933_like; pfam03486 1111678001039 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 1111678001040 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 1111678001041 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1111678001042 putative substrate binding site [chemical binding]; other site 1111678001043 putative ATP binding site [chemical binding]; other site 1111678001044 Protein of unknown function (DUF1398); Region: DUF1398; cl11576 1111678001045 Similar to ABC transporter ATP binding protein; predicted non-fuctional due to C to T conversion leading to TAA stop codon 1111678001046 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1111678001047 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1111678001048 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1111678001049 Walker A/P-loop; other site 1111678001050 ATP binding site [chemical binding]; other site 1111678001051 Q-loop/lid; other site 1111678001052 ABC transporter signature motif; other site 1111678001053 Walker B; other site 1111678001054 D-loop; other site 1111678001055 H-loop/switch region; other site 1111678001056 Uncharacterized protein/domain associated with GTPases [Function unknown]; Region: COG3597 1111678001057 putative oxidoreductase; Provisional; Region: PRK10206 1111678001058 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1111678001059 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1111678001060 S-ribosylhomocysteinase; Provisional; Region: PRK02260 1111678001061 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 1111678001062 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1111678001063 active site 1111678001064 catalytic tetrad [active] 1111678001065 Isochorismatase family; Region: Isochorismatase; pfam00857 1111678001066 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1111678001067 catalytic triad [active] 1111678001068 conserved cis-peptide bond; other site 1111678001069 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 1111678001070 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1111678001071 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1111678001072 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1111678001073 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1111678001074 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1111678001075 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 1111678001076 ATP cone domain; Region: ATP-cone; pfam03477 1111678001077 Class III ribonucleotide reductase; Region: RNR_III; cd01675 1111678001078 effector binding site; other site 1111678001079 active site 1111678001080 Zn binding site [ion binding]; other site 1111678001081 glycine loop; other site 1111678001082 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 1111678001083 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 1111678001084 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1111678001085 FeS/SAM binding site; other site 1111678001086 Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; pfam10087 1111678001087 Cytochrome c7; Region: Cytochrome_C7; cl19206 1111678001088 enolase; Provisional; Region: eno; PRK00077 1111678001089 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1111678001090 dimer interface [polypeptide binding]; other site 1111678001091 metal binding site [ion binding]; metal-binding site 1111678001092 substrate binding pocket [chemical binding]; other site 1111678001093 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13642 1111678001094 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1111678001095 Walker A/P-loop; other site 1111678001096 ATP binding site [chemical binding]; other site 1111678001097 Q-loop/lid; other site 1111678001098 ABC transporter signature motif; other site 1111678001099 Walker B; other site 1111678001100 D-loop; other site 1111678001101 H-loop/switch region; other site 1111678001102 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13643 1111678001103 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1111678001104 Walker A/P-loop; other site 1111678001105 ATP binding site [chemical binding]; other site 1111678001106 Q-loop/lid; other site 1111678001107 ABC transporter signature motif; other site 1111678001108 Walker B; other site 1111678001109 D-loop; other site 1111678001110 H-loop/switch region; other site 1111678001111 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1111678001112 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1111678001113 active site 1111678001114 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1111678001115 Similar to glucosyltransferase; predicted non-functional due to transposon insertion 1111678001116 Similar to Tn946 Transposase; predicted non-functional due to frameshift 1111678001117 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 1111678001118 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 1111678001119 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 1111678001120 trimer interface [polypeptide binding]; other site 1111678001121 active site 1111678001122 substrate binding site [chemical binding]; other site 1111678001123 CoA binding site [chemical binding]; other site 1111678001124 M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670 1111678001125 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1111678001126 metal binding site [ion binding]; metal-binding site 1111678001127 putative dimer interface [polypeptide binding]; other site 1111678001128 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1111678001129 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 1111678001130 Glucosyl transferase GtrII; Region: Glucos_trans_II; cl10304 1111678001131 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1111678001132 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1111678001133 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1111678001134 RNA binding surface [nucleotide binding]; other site 1111678001135 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 1111678001136 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 1111678001137 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 1111678001138 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 1111678001139 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 1111678001140 RNA binding site [nucleotide binding]; other site 1111678001141 SprT homologues; Region: SprT; cl01182 1111678001142 hypothetical protein; Provisional; Region: PRK04351 1111678001143 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 1111678001144 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 1111678001145 active site 1111678001146 purine riboside binding site [chemical binding]; other site 1111678001147 Similar to hypothetical protein; predicted non-functional due to frameshift 1111678001148 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 1111678001149 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1111678001150 DNA binding residues [nucleotide binding] 1111678001151 putative dimer interface [polypeptide binding]; other site 1111678001152 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1111678001153 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 1111678001154 RNA-metabolizing metallo-beta-lactamase; Region: RMMBL; pfam07521 1111678001155 hypothetical protein; Provisional; Region: PRK13667 1111678001156 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1111678001157 Glycoprotease family; Region: Peptidase_M22; pfam00814 1111678001158 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1111678001159 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1111678001160 Coenzyme A binding pocket [chemical binding]; other site 1111678001161 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1111678001162 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1111678001163 Coenzyme A binding pocket [chemical binding]; other site 1111678001164 UGMP family protein; Validated; Region: PRK09604 1111678001165 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 1111678001166 Similar to hypothetical protein; predicted to be non-functional due to frameshift 1111678001167 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 1111678001168 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 1111678001169 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 1111678001170 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 1111678001171 Walker A/P-loop; other site 1111678001172 ATP binding site [chemical binding]; other site 1111678001173 Q-loop/lid; other site 1111678001174 ABC transporter signature motif; other site 1111678001175 Walker B; other site 1111678001176 D-loop; other site 1111678001177 H-loop/switch region; other site 1111678001178 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 1111678001179 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1111678001180 dimer interface [polypeptide binding]; other site 1111678001181 conserved gate region; other site 1111678001182 putative PBP binding loops; other site 1111678001183 ABC-ATPase subunit interface; other site 1111678001184 ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport and metabolism]; Region: COG3639 1111678001185 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1111678001186 dimer interface [polypeptide binding]; other site 1111678001187 conserved gate region; other site 1111678001188 putative PBP binding loops; other site 1111678001189 ABC-ATPase subunit interface; other site 1111678001190 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1111678001191 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 1111678001192 active site 1111678001193 metal binding site [ion binding]; metal-binding site 1111678001194 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1111678001195 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 1111678001196 dimer interface [polypeptide binding]; other site 1111678001197 catalytic triad [active] 1111678001198 peroxidatic and resolving cysteines [active] 1111678001199 Aminopeptidase N [Amino acid transport and metabolism]; Region: PepN; COG0308 1111678001200 Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601 1111678001201 Zn binding site [ion binding]; other site 1111678001202 ERAP1-like C-terminal domain; Region: ERAP1_C; pfam11838 1111678001203 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1111678001204 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1111678001205 putative substrate translocation pore; other site 1111678001206 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1111678001207 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 1111678001208 putative DNA binding site [nucleotide binding]; other site 1111678001209 putative Zn2+ binding site [ion binding]; other site 1111678001210 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1111678001211 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1111678001212 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1111678001213 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1111678001214 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1111678001215 Walker A/P-loop; other site 1111678001216 ATP binding site [chemical binding]; other site 1111678001217 Q-loop/lid; other site 1111678001218 ABC transporter signature motif; other site 1111678001219 Walker B; other site 1111678001220 D-loop; other site 1111678001221 H-loop/switch region; other site 1111678001222 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1111678001223 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1111678001224 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1111678001225 Walker A/P-loop; other site 1111678001226 ATP binding site [chemical binding]; other site 1111678001227 Q-loop/lid; other site 1111678001228 ABC transporter signature motif; other site 1111678001229 Walker B; other site 1111678001230 D-loop; other site 1111678001231 H-loop/switch region; other site 1111678001232 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1111678001233 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1111678001234 hinge; other site 1111678001235 active site 1111678001236 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4443 1111678001237 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 1111678001238 ATP binding site [chemical binding]; other site 1111678001239 substrate interface [chemical binding]; other site 1111678001240 Similar to putative permease; predicted to be non-functional due to frameshift 1111678001241 Protein of unknown function (DUF3397); Region: DUF3397; pfam11877 1111678001242 BioY family; Region: BioY; pfam02632 1111678001243 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 1111678001244 putative deacylase active site [active] 1111678001245 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1111678001246 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1111678001247 Predicted membrane protein [Function unknown]; Region: COG3859 1111678001248 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1111678001249 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1111678001250 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1111678001251 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1111678001252 acetoin reductases; Region: 23BDH; TIGR02415 1111678001253 NAD(P) binding site [chemical binding]; other site 1111678001254 active site 1111678001255 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1111678001256 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1111678001257 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 1111678001258 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1111678001259 Walker A/P-loop; other site 1111678001260 ATP binding site [chemical binding]; other site 1111678001261 Q-loop/lid; other site 1111678001262 ABC transporter signature motif; other site 1111678001263 Walker B; other site 1111678001264 D-loop; other site 1111678001265 H-loop/switch region; other site 1111678001266 NIL domain; Region: NIL; pfam09383 1111678001267 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1111678001268 dimer interface [polypeptide binding]; other site 1111678001269 conserved gate region; other site 1111678001270 putative PBP binding loops; other site 1111678001271 ABC-ATPase subunit interface; other site 1111678001272 hypothetical protein; Provisional; Region: PRK13661 1111678001273 Similar to ABC-type cobalt transport system, ATPase component; predicted non-functional due to C terminal truncation 1111678001274 Similar to cobalt ABC transporter permease; prediected non-functional due frameshift 1111678001275 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1111678001276 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1111678001277 non-specific DNA binding site [nucleotide binding]; other site 1111678001278 salt bridge; other site 1111678001279 sequence-specific DNA binding site [nucleotide binding]; other site 1111678001280 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1111678001281 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1111678001282 Walker A/P-loop; other site 1111678001283 ATP binding site [chemical binding]; other site 1111678001284 Q-loop/lid; other site 1111678001285 ABC transporter signature motif; other site 1111678001286 Walker B; other site 1111678001287 D-loop; other site 1111678001288 H-loop/switch region; other site 1111678001289 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1111678001290 ABC-ATPase subunit interface; other site 1111678001291 dimer interface [polypeptide binding]; other site 1111678001292 putative PBP binding regions; other site 1111678001293 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1111678001294 ABC-ATPase subunit interface; other site 1111678001295 dimer interface [polypeptide binding]; other site 1111678001296 putative PBP binding regions; other site 1111678001297 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 1111678001298 putative ligand binding residues [chemical binding]; other site 1111678001299 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1111678001300 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1111678001301 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1111678001302 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1111678001303 dimerization interface [polypeptide binding]; other site 1111678001304 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1111678001305 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1111678001306 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1111678001307 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1111678001308 putative substrate translocation pore; other site 1111678001309 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1111678001310 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1111678001311 active site 1111678001312 catalytic tetrad [active] 1111678001313 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1111678001314 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1111678001315 active site 1111678001316 metal binding site [ion binding]; metal-binding site 1111678001317 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1111678001318 catalytic core [active] 1111678001319 peroxiredoxin; Region: AhpC; TIGR03137 1111678001320 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1111678001321 dimer interface [polypeptide binding]; other site 1111678001322 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1111678001323 catalytic triad [active] 1111678001324 peroxidatic and resolving cysteines [active] 1111678001325 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 1111678001326 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 1111678001327 catalytic residue [active] 1111678001328 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 1111678001329 catalytic residues [active] 1111678001330 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 1111678001331 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1111678001332 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1111678001333 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1111678001334 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1111678001335 Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717 1111678001336 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1111678001337 recombination protein RecR; Reviewed; Region: recR; PRK00076 1111678001338 RecR protein; Region: RecR; pfam02132 1111678001339 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1111678001340 putative active site [active] 1111678001341 putative metal-binding site [ion binding]; other site 1111678001342 tetramer interface [polypeptide binding]; other site 1111678001343 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 1111678001344 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1111678001345 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 1111678001346 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 1111678001347 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1111678001348 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1111678001349 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1111678001350 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1111678001351 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1111678001352 peptide binding site [polypeptide binding]; other site 1111678001353 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1111678001354 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1111678001355 peptide binding site [polypeptide binding]; other site 1111678001356 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1111678001357 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1111678001358 dimer interface [polypeptide binding]; other site 1111678001359 conserved gate region; other site 1111678001360 putative PBP binding loops; other site 1111678001361 ABC-ATPase subunit interface; other site 1111678001362 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1111678001363 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1111678001364 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1111678001365 dimer interface [polypeptide binding]; other site 1111678001366 conserved gate region; other site 1111678001367 putative PBP binding loops; other site 1111678001368 ABC-ATPase subunit interface; other site 1111678001369 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1111678001370 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1111678001371 Walker A/P-loop; other site 1111678001372 ATP binding site [chemical binding]; other site 1111678001373 Q-loop/lid; other site 1111678001374 ABC transporter signature motif; other site 1111678001375 Walker B; other site 1111678001376 D-loop; other site 1111678001377 H-loop/switch region; other site 1111678001378 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1111678001379 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1111678001380 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1111678001381 Walker A/P-loop; other site 1111678001382 ATP binding site [chemical binding]; other site 1111678001383 Q-loop/lid; other site 1111678001384 ABC transporter signature motif; other site 1111678001385 Walker B; other site 1111678001386 D-loop; other site 1111678001387 H-loop/switch region; other site 1111678001388 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1111678001389 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 1111678001390 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 1111678001391 G1 box; other site 1111678001392 putative GEF interaction site [polypeptide binding]; other site 1111678001393 GTP/Mg2+ binding site [chemical binding]; other site 1111678001394 Switch I region; other site 1111678001395 G2 box; other site 1111678001396 G3 box; other site 1111678001397 Switch II region; other site 1111678001398 G4 box; other site 1111678001399 G5 box; other site 1111678001400 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 1111678001401 Elongation Factor G, domain II; Region: EFG_II; pfam14492 1111678001402 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 1111678001403 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1111678001404 ATP binding site [chemical binding]; other site 1111678001405 Mg++ binding site [ion binding]; other site 1111678001406 motif III; other site 1111678001407 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1111678001408 nucleotide binding region [chemical binding]; other site 1111678001409 ATP-binding site [chemical binding]; other site 1111678001410 GTPase Era; Reviewed; Region: era; PRK00089 1111678001411 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1111678001412 G1 box; other site 1111678001413 GTP/Mg2+ binding site [chemical binding]; other site 1111678001414 Switch I region; other site 1111678001415 G2 box; other site 1111678001416 Switch II region; other site 1111678001417 G3 box; other site 1111678001418 G4 box; other site 1111678001419 G5 box; other site 1111678001420 KH domain; Region: KH_2; pfam07650 1111678001421 asparagine synthetase B; Provisional; Region: asnB; PRK09431 1111678001422 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1111678001423 dimer interface [polypeptide binding]; other site 1111678001424 active site 1111678001425 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1111678001426 Ligand Binding Site [chemical binding]; other site 1111678001427 Molecular Tunnel; other site 1111678001428 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 1111678001429 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1111678001430 DNA binding site [nucleotide binding] 1111678001431 catalytic residue [active] 1111678001432 H2TH interface [polypeptide binding]; other site 1111678001433 putative catalytic residues [active] 1111678001434 turnover-facilitating residue; other site 1111678001435 intercalation triad [nucleotide binding]; other site 1111678001436 8OG recognition residue [nucleotide binding]; other site 1111678001437 putative reading head residues; other site 1111678001438 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1111678001439 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1111678001440 recombinase A; Provisional; Region: recA; PRK09354 1111678001441 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1111678001442 hexamer interface [polypeptide binding]; other site 1111678001443 Walker A motif; other site 1111678001444 ATP binding site [chemical binding]; other site 1111678001445 Walker B motif; other site 1111678001446 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1111678001447 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1111678001448 Protein of unknown function (DUF964); Region: DUF964; cl01483 1111678001449 Uncharacterized protein conserved in bacteria (DUF2129); Region: DUF2129; pfam09902 1111678001450 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 1111678001451 putative active site [active] 1111678001452 putative triphosphate binding site [ion binding]; other site 1111678001453 putative metal binding residues [ion binding]; other site 1111678001454 Protein of unknown function (DUF817); Region: DUF817; pfam05675 1111678001455 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1111678001456 synthetase active site [active] 1111678001457 NTP binding site [chemical binding]; other site 1111678001458 metal binding site [ion binding]; metal-binding site 1111678001459 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 1111678001460 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1111678001461 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1111678001462 active site 1111678001463 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1111678001464 active site 1111678001465 lysine transporter; Provisional; Region: PRK10836 1111678001466 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 1111678001467 Predicted flavoprotein [General function prediction only]; Region: COG0431 1111678001468 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 1111678001469 Similar to Tn982 Transposase; predicted non-functional due to frameshift 1111678001470 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1111678001471 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1111678001472 dimer interface [polypeptide binding]; other site 1111678001473 putative anticodon binding site; other site 1111678001474 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 1111678001475 motif 1; other site 1111678001476 active site 1111678001477 motif 2; other site 1111678001478 motif 3; other site 1111678001479 Similar to LysR family transcriptional regulator YeiE; predicted non-functional due to frameshift 1111678001480 Conserved hypothetical protein 698; Region: Cons_hypoth698; pfam03601 1111678001481 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 1111678001482 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 1111678001483 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1111678001484 NAD binding site [chemical binding]; other site 1111678001485 dimer interface [polypeptide binding]; other site 1111678001486 substrate binding site [chemical binding]; other site 1111678001487 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1111678001488 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1111678001489 LysR substrate binding domain; Region: LysR_substrate; pfam03466 1111678001490 dimerization interface [polypeptide binding]; other site 1111678001491 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1111678001492 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1111678001493 C4-dicarboxylate transporters of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_C4-dicarb_trans; cd09325 1111678001494 gating phenylalanine in ion channel; other site 1111678001495 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 1111678001496 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 1111678001497 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 1111678001498 Ligand Binding Site [chemical binding]; other site 1111678001499 Similar to permase of the major faciliatator superfamily; predicted non-functional due to frameshift 1111678001500 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1111678001501 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1111678001502 Acyl carrier protein phosphodiesterase [Lipid metabolism]; Region: AcpD; COG1182 1111678001503 OsmC-like protein; Region: OsmC; cl00767 1111678001504 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1111678001505 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1111678001506 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1111678001507 active site 1111678001508 HIGH motif; other site 1111678001509 dimer interface [polypeptide binding]; other site 1111678001510 KMSKS motif; other site 1111678001511 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1111678001512 RNA binding surface [nucleotide binding]; other site 1111678001513 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 1111678001514 Transglycosylase; Region: Transgly; pfam00912 1111678001515 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1111678001516 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1111678001517 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 1111678001518 oligomer interface [polypeptide binding]; other site 1111678001519 active site 1111678001520 metal binding site [ion binding]; metal-binding site 1111678001521 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1111678001522 catalytic residues [active] 1111678001523 Domain of unknown function (DUF4479); Region: DUF4479; pfam14794 1111678001524 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1111678001525 putative tRNA-binding site [nucleotide binding]; other site 1111678001526 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 1111678001527 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 1111678001528 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1111678001529 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 1111678001530 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1111678001531 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1111678001532 dimer interface [polypeptide binding]; other site 1111678001533 ssDNA binding site [nucleotide binding]; other site 1111678001534 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1111678001535 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1111678001536 oligomerisation interface [polypeptide binding]; other site 1111678001537 mobile loop; other site 1111678001538 roof hairpin; other site 1111678001539 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1111678001540 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1111678001541 ring oligomerisation interface [polypeptide binding]; other site 1111678001542 ATP/Mg binding site [chemical binding]; other site 1111678001543 stacking interactions; other site 1111678001544 hinge regions; other site 1111678001545 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 1111678001546 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1111678001547 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 1111678001548 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1111678001549 putative active site [active] 1111678001550 heme pocket [chemical binding]; other site 1111678001551 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1111678001552 dimer interface [polypeptide binding]; other site 1111678001553 phosphorylation site [posttranslational modification] 1111678001554 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1111678001555 ATP binding site [chemical binding]; other site 1111678001556 Mg2+ binding site [ion binding]; other site 1111678001557 G-X-G motif; other site 1111678001558 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1111678001559 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1111678001560 active site 1111678001561 phosphorylation site [posttranslational modification] 1111678001562 intermolecular recognition site; other site 1111678001563 dimerization interface [polypeptide binding]; other site 1111678001564 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1111678001565 DNA binding site [nucleotide binding] 1111678001566 thymidylate kinase; Validated; Region: tmk; PRK00698 1111678001567 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1111678001568 TMP-binding site; other site 1111678001569 ATP-binding site [chemical binding]; other site 1111678001570 DNA polymerase III subunit delta'; Validated; Region: PRK07276 1111678001571 DNA polymerase III subunit delta'; Validated; Region: PRK08485 1111678001572 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 1111678001573 Regulator of replication initiation timing [Replication, recombination, and repair]; Region: COG4467 1111678001574 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1111678001575 putative homodimer interface [polypeptide binding]; other site 1111678001576 putative SAM binding site [chemical binding]; other site 1111678001577 Similar to ABC-type multidrug transport system permease component; predicted non-functional due to frameshfit 1111678001578 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1111678001579 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 1111678001580 Walker A/P-loop; other site 1111678001581 ATP binding site [chemical binding]; other site 1111678001582 Q-loop/lid; other site 1111678001583 ABC transporter signature motif; other site 1111678001584 Walker B; other site 1111678001585 D-loop; other site 1111678001586 H-loop/switch region; other site 1111678001587 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 1111678001588 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1111678001589 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 1111678001590 dimerization interface [polypeptide binding]; other site 1111678001591 putative Zn2+ binding site [ion binding]; other site 1111678001592 putative DNA binding site [nucleotide binding]; other site 1111678001593 mevalonate kinase; Region: mevalon_kin; TIGR00549 1111678001594 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1111678001595 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1111678001596 Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407 1111678001597 diphosphomevalonate decarboxylase; Region: PLN02407 1111678001598 Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577 1111678001599 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1111678001600 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1111678001601 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 1111678001602 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 1111678001603 homotetramer interface [polypeptide binding]; other site 1111678001604 FMN binding site [chemical binding]; other site 1111678001605 homodimer contacts [polypeptide binding]; other site 1111678001606 putative active site [active] 1111678001607 putative substrate binding site [chemical binding]; other site 1111678001608 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1111678001609 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1111678001610 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1111678001611 Simliar to carbon starvation protein A; predicted non-functional due to C to T conversion leading to TAA stop 1111678001612 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 1111678001613 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1111678001614 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1111678001615 Simliart to DeoR family transcriptional regulator, predicted non-functional due to frameshift 1111678001616 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 1111678001617 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1111678001618 ATP binding site [chemical binding]; other site 1111678001619 Mg++ binding site [ion binding]; other site 1111678001620 motif III; other site 1111678001621 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1111678001622 nucleotide binding region [chemical binding]; other site 1111678001623 ATP-binding site [chemical binding]; other site 1111678001624 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1111678001625 putative active site [active] 1111678001626 Similar to transcriptional regulator; predicted non-functional due to TAA stop codon 1111678001627 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 1111678001628 active site 1111678001629 P-loop; other site 1111678001630 phosphorylation site [posttranslational modification] 1111678001631 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 1111678001632 active site 1111678001633 methionine cluster; other site 1111678001634 phosphorylation site [posttranslational modification] 1111678001635 metal binding site [ion binding]; metal-binding site 1111678001636 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1111678001637 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1111678001638 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1111678001639 putative active site [active] 1111678001640 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 1111678001641 6-phospho-beta-glucosidase; Reviewed; Region: celA; PRK09589 1111678001642 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 1111678001643 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 1111678001644 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1111678001645 nucleotide binding pocket [chemical binding]; other site 1111678001646 K-X-D-G motif; other site 1111678001647 catalytic site [active] 1111678001648 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1111678001649 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1111678001650 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 1111678001651 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 1111678001652 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1111678001653 Dimer interface [polypeptide binding]; other site 1111678001654 BRCT sequence motif; other site 1111678001655 putative lipid kinase; Reviewed; Region: PRK13055 1111678001656 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1111678001657 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1111678001658 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1111678001659 Walker A/P-loop; other site 1111678001660 ATP binding site [chemical binding]; other site 1111678001661 Q-loop/lid; other site 1111678001662 ABC transporter signature motif; other site 1111678001663 Walker B; other site 1111678001664 D-loop; other site 1111678001665 H-loop/switch region; other site 1111678001666 TOBE domain; Region: TOBE_2; pfam08402 1111678001667 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 1111678001668 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 1111678001669 dimer interface [polypeptide binding]; other site 1111678001670 PYR/PP interface [polypeptide binding]; other site 1111678001671 TPP binding site [chemical binding]; other site 1111678001672 substrate binding site [chemical binding]; other site 1111678001673 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 1111678001674 Domain of unknown function; Region: EKR; smart00890 1111678001675 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 1111678001676 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 1111678001677 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 1111678001678 TPP-binding site [chemical binding]; other site 1111678001679 dimer interface [polypeptide binding]; other site 1111678001680 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1111678001681 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1111678001682 Uncharacterized conserved protein [Function unknown]; Region: COG1624 1111678001683 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 1111678001684 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 1111678001685 YbbR-like protein; Region: YbbR; pfam07949 1111678001686 YbbR-like protein; Region: YbbR; pfam07949 1111678001687 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 1111678001688 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1111678001689 active site 1111678001690 substrate binding site [chemical binding]; other site 1111678001691 metal binding site [ion binding]; metal-binding site 1111678001692 Similar to Trehalose operon transcriptional repressor; predicted non-functional due to G to T conversion leading to TAA stop 1111678001693 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1111678001694 HPr interaction site; other site 1111678001695 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1111678001696 active site 1111678001697 phosphorylation site [posttranslational modification] 1111678001698 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 1111678001699 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1111678001700 active site turn [active] 1111678001701 phosphorylation site [posttranslational modification] 1111678001702 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1111678001703 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 1111678001704 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 1111678001705 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 1111678001706 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 1111678001707 beta-phosphoglucomutase; Region: bPGM; TIGR01990 1111678001708 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 1111678001709 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1111678001710 motif II; other site 1111678001711 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1111678001712 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 1111678001713 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 1111678001714 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1111678001715 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1111678001716 Coenzyme A binding pocket [chemical binding]; other site 1111678001717 Phage integrase, N-terminal SAM-like domain; Region: Phage_int_SAM_4; cl17873 1111678001718 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 1111678001719 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1111678001720 active site 1111678001721 DNA binding site [nucleotide binding] 1111678001722 Int/Topo IB signature motif; other site 1111678001723 Similar to Tn982 transposase; predicted non functional due to frameshift 1111678001724 Similar to Type I restriction-modification system, restriction subunit R; predicted non-functional due to T addition leading to TGA stop 1111678001725 HsdM N-terminal domain; Region: HsdM_N; pfam12161 1111678001726 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 1111678001727 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1111678001728 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1111678001729 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 1111678001730 Helix-turn-helix domain; Region: HTH_28; pfam13518 1111678001731 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1111678001732 Helix-turn-helix domain; Region: HTH_28; pfam13518 1111678001733 Similar to IS1077E transposase; predicted non-functional due to frameshift 1111678001734 Similar to plasmid replication protein; predicted non-functional due to TGA stop 1111678001735 Similar to transcriptional regulator; predicted non-functional due to C to A conversion leading to TAG stop 1111678001736 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1111678001737 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1111678001738 dimerization interface 3.5A [polypeptide binding]; other site 1111678001739 active site 1111678001740 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1111678001741 dimer interface [polypeptide binding]; other site 1111678001742 substrate binding site [chemical binding]; other site 1111678001743 ATP binding site [chemical binding]; other site 1111678001744 Predicted membrane protein [Function unknown]; Region: COG4720 1111678001745 hypothetical protein; Provisional; Region: PRK13690 1111678001746 Similar to Serine-pyruvate aminotransferase; predicted non-functional due to frameshift 1111678001747 CTP synthetase; Validated; Region: pyrG; PRK05380 1111678001748 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1111678001749 Catalytic site [active] 1111678001750 active site 1111678001751 UTP binding site [chemical binding]; other site 1111678001752 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1111678001753 active site 1111678001754 putative oxyanion hole; other site 1111678001755 catalytic triad [active] 1111678001756 Domain of unknown function (DUF4288); Region: DUF4288; pfam14119 1111678001757 Similar to hypothetical protein; predicted non-functional due to T to A conversion leading to TAA stop 1111678001758 Similar to hypothetical protein; predicted non-functional due to T to A conversion leading to TAA stop 1111678001759 YcxB-like protein; Region: YcxB; pfam14317 1111678001760 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 1111678001761 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 1111678001762 NAD(P) binding site [chemical binding]; other site 1111678001763 LDH/MDH dimer interface [polypeptide binding]; other site 1111678001764 substrate binding site [chemical binding]; other site 1111678001765 Predicted membrane protein [Function unknown]; Region: COG4420 1111678001766 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 1111678001767 Nucleoside 2-deoxyribosyltransferase [Nucleotide transport and metabolism]; Region: COG3613 1111678001768 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 1111678001769 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 1111678001770 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 1111678001771 Substrate-binding site [chemical binding]; other site 1111678001772 Substrate specificity [chemical binding]; other site 1111678001773 Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529 1111678001774 putative active site [active] 1111678001775 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 1111678001776 putative active site [active] 1111678001777 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK07279 1111678001778 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 1111678001779 active site 1111678001780 PHP Thumb interface [polypeptide binding]; other site 1111678001781 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 1111678001782 Helix-hairpin-helix motif; Region: HHH_6; pfam14579 1111678001783 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1111678001784 generic binding surface II; other site 1111678001785 generic binding surface I; other site 1111678001786 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 1111678001787 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 1111678001788 EDD domain protein, DegV family; Region: DegV; TIGR00762 1111678001789 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1111678001790 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 1111678001791 active site 1111678001792 catalytic triad [active] 1111678001793 oxyanion hole [active] 1111678001794 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1111678001795 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 1111678001796 Uncharacterized protein conserved in bacteria (DUF2140); Region: DUF2140; cl11548 1111678001797 histone-like DNA-binding protein HU; Region: HU; cd13831 1111678001798 dimer interface [polypeptide binding]; other site 1111678001799 DNA binding site [nucleotide binding] 1111678001800 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 1111678001801 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1111678001802 Coenzyme A binding pocket [chemical binding]; other site 1111678001803 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 1111678001804 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 1111678001805 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1111678001806 DNA binding site [nucleotide binding] 1111678001807 active site 1111678001808 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 1111678001809 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 1111678001810 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1111678001811 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1111678001812 N-acetyltransferase; Region: Acetyltransf_2; cl00949 1111678001813 Similar to Tn946 Transposase; predicted non-functional due to frameshift 1111678001814 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1111678001815 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1111678001816 Walker A/P-loop; other site 1111678001817 ATP binding site [chemical binding]; other site 1111678001818 Q-loop/lid; other site 1111678001819 ABC transporter signature motif; other site 1111678001820 Walker B; other site 1111678001821 D-loop; other site 1111678001822 H-loop/switch region; other site 1111678001823 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1111678001824 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1111678001825 Similar to LytR family transcriptional regulator; predicted non-functional due to transposon insertion 1111678001826 Similar to Tn982 Transposase; predicted non-functional due truncation 1111678001827 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1111678001828 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1111678001829 catalytic residue [active] 1111678001830 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1111678001831 NlpC/P60 family; Region: NLPC_P60; cl17555 1111678001832 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1111678001833 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1111678001834 peptide binding site [polypeptide binding]; other site 1111678001835 cysteine synthase; Region: PLN02565 1111678001836 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1111678001837 dimer interface [polypeptide binding]; other site 1111678001838 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1111678001839 catalytic residue [active] 1111678001840 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 1111678001841 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1111678001842 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1111678001843 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1111678001844 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1111678001845 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 1111678001846 Transglycosylase; Region: Transgly; pfam00912 1111678001847 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1111678001848 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 1111678001849 hypothetical protein; Provisional; Region: PRK13660 1111678001850 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 1111678001851 ArsC family; Region: ArsC; pfam03960 1111678001852 putative catalytic residues [active] 1111678001853 thiol/disulfide switch; other site 1111678001854 Uncharacterized protein family (UPF0223); Region: UPF0223; cl11484 1111678001855 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 1111678001856 active site 1111678001857 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase); Region: EPSP_synthase; pfam00275 1111678001858 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1111678001859 hinge; other site 1111678001860 active site 1111678001861 Helix-turn-helix domain; Region: HTH_28; pfam13518 1111678001862 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1111678001863 Helix-turn-helix domain; Region: HTH_28; pfam13518 1111678001864 putative transposase OrfB; Reviewed; Region: PHA02517 1111678001865 HTH-like domain; Region: HTH_21; pfam13276 1111678001866 Integrase core domain; Region: rve; pfam00665 1111678001867 Integrase core domain; Region: rve_2; pfam13333 1111678001868 putative transposase OrfB; Reviewed; Region: PHA02517 1111678001869 HTH-like domain; Region: HTH_21; pfam13276 1111678001870 Integrase core domain; Region: rve; pfam00665 1111678001871 Integrase core domain; Region: rve_3; pfam13683 1111678001872 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1111678001873 Transposase; Region: HTH_Tnp_1; pfam01527 1111678001874 trigger factor; Provisional; Region: tig; PRK01490 1111678001875 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1111678001876 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1111678001877 DNA primase; Validated; Region: dnaG; PRK05667 1111678001878 CHC2 zinc finger; Region: zf-CHC2; pfam01807 1111678001879 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1111678001880 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1111678001881 active site 1111678001882 metal binding site [ion binding]; metal-binding site 1111678001883 interdomain interaction site; other site 1111678001884 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 1111678001885 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 1111678001886 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1111678001887 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1111678001888 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1111678001889 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1111678001890 DNA binding residues [nucleotide binding] 1111678001891 Similar to transcriptonal regulator; predicted non-functional due to frameshift 1111678001892 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 1111678001893 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1111678001894 putative substrate translocation pore; other site 1111678001895 Similar to predicted membrane protein (TMS5); predicted non-functional due to frameshift 1111678001896 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 1111678001897 Double zinc ribbon; Region: DZR; pfam12773 1111678001898 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 1111678001899 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1111678001900 Walker A motif; other site 1111678001901 ATP binding site [chemical binding]; other site 1111678001902 Walker B motif; other site 1111678001903 arginine finger; other site 1111678001904 UvrB/uvrC motif; Region: UVR; pfam02151 1111678001905 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1111678001906 Walker A motif; other site 1111678001907 ATP binding site [chemical binding]; other site 1111678001908 Walker B motif; other site 1111678001909 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1111678001910 Predicted transcriptional regulator [Transcription]; Region: COG1959 1111678001911 Rrf2 family protein; Region: rrf2_super; TIGR00738 1111678001912 Similar to NAD-dependent glyceraldehyde-3-phosphate dehydrogenase (EC 1.2.1.12); predicted non-functional due to G to T conversion leading to TAA stop 1111678001913 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1111678001914 active site 1111678001915 catalytic residues [active] 1111678001916 metal binding site [ion binding]; metal-binding site 1111678001917 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 1111678001918 putative active site [active] 1111678001919 Ap4A binding site [chemical binding]; other site 1111678001920 nudix motif; other site 1111678001921 putative metal binding site [ion binding]; other site 1111678001922 excinuclease ABC subunit B; Provisional; Region: PRK05298 1111678001923 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1111678001924 ATP binding site [chemical binding]; other site 1111678001925 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1111678001926 nucleotide binding region [chemical binding]; other site 1111678001927 ATP-binding site [chemical binding]; other site 1111678001928 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1111678001929 UvrB/uvrC motif; Region: UVR; pfam02151 1111678001930 Similar to amino acid ABC transporter periplasmic protein; predicted non-functional due to transposon insertion 1111678001931 HTH-like domain; Region: HTH_21; pfam13276 1111678001932 Integrase core domain; Region: rve; pfam00665 1111678001933 Integrase core domain; Region: rve_2; pfam13333 1111678001934 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1111678001935 Helix-turn-helix domain; Region: HTH_28; pfam13518 1111678001936 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1111678001937 Helix-turn-helix domain; Region: HTH_28; pfam13518 1111678001938 Similar to Acetylornithine deacetylase (EC 3.5.1.16); predicted non-functional due to frameshift 1111678001939 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1111678001940 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 1111678001941 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 1111678001942 NAD binding site [chemical binding]; other site 1111678001943 homotetramer interface [polypeptide binding]; other site 1111678001944 homodimer interface [polypeptide binding]; other site 1111678001945 substrate binding site [chemical binding]; other site 1111678001946 active site 1111678001947 OxaA-like protein precursor; Provisional; Region: PRK02463 1111678001948 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 1111678001949 Eukaryotic phosphomannomutase; Region: PMM; cl17107 1111678001950 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 1111678001951 Predicted membrane protein [Function unknown]; Region: COG4684 1111678001952 Flavoprotein; Region: Flavoprotein; cl19190 1111678001953 phosphopantothenate--cysteine ligase; Validated; Region: PRK06732 1111678001954 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 1111678001955 active site 1 [active] 1111678001956 dimer interface [polypeptide binding]; other site 1111678001957 hexamer interface [polypeptide binding]; other site 1111678001958 active site 2 [active] 1111678001959 Similar to cation-transporting ATPase; predicted non-functional due to conversions leading to TAA and TGA stop codons 1111678001960 Similar to GNAT family acetyltransferase; predicted non-functional due to truncation 1111678001961 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1111678001962 Transposase; Region: HTH_Tnp_1; pfam01527 1111678001963 putative transposase OrfB; Reviewed; Region: PHA02517 1111678001964 HTH-like domain; Region: HTH_21; pfam13276 1111678001965 Integrase core domain; Region: rve; pfam00665 1111678001966 Integrase core domain; Region: rve_3; pfam13683 1111678001967 Similar to FtsK/SpoIIIE family protein; predicted non-functional due to TAA stop codon 1111678001968 Replication initiation factor; Region: Rep_trans; pfam02486 1111678001969 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1111678001970 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1111678001971 active site 1111678001972 DNA binding site [nucleotide binding] 1111678001973 Int/Topo IB signature motif; other site 1111678001974 thymidine kinase; Provisional; Region: PRK04296 1111678001975 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1111678001976 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1111678001977 RF-1 domain; Region: RF-1; pfam00472 1111678001978 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 1111678001979 dimer interface [polypeptide binding]; other site 1111678001980 FMN binding site [chemical binding]; other site 1111678001981 NADPH bind site [chemical binding]; other site 1111678001982 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 1111678001983 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1111678001984 S-adenosylmethionine binding site [chemical binding]; other site 1111678001985 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1111678001986 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 1111678001987 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1111678001988 dimer interface [polypeptide binding]; other site 1111678001989 active site 1111678001990 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1111678001991 folate binding site [chemical binding]; other site 1111678001992 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1111678001993 Lysozyme-like; Region: Lysozyme_like; pfam13702 1111678001994 3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355 1111678001995 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1111678001996 catalytic residue [active] 1111678001997 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_3; cd12174 1111678001998 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1111678001999 putative ligand binding site [chemical binding]; other site 1111678002000 putative NAD binding site [chemical binding]; other site 1111678002001 putative catalytic site [active] 1111678002002 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1111678002003 phosphoserine phosphatase SerB; Region: serB; TIGR00338 1111678002004 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1111678002005 motif II; other site 1111678002006 Similar to nucleose phosphatase; predicted non-functional due to G to T conversion leading to TAA stop 1111678002007 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1111678002008 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1111678002009 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1111678002010 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1111678002011 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 1111678002012 Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047 1111678002013 DNA binding residues [nucleotide binding] 1111678002014 putative dimer interface [polypeptide binding]; other site 1111678002015 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cl00217 1111678002016 dimer interface [polypeptide binding]; other site 1111678002017 flavodoxin; Validated; Region: PRK07308 1111678002018 Similar to membrane-bound transport protein; predicted non-functional due to frameshift 1111678002019 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1111678002020 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1111678002021 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1111678002022 active site 1111678002023 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 1111678002024 Predicted membrane protein [Function unknown]; Region: COG2246 1111678002025 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1111678002026 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1111678002027 Tim44-like domain; Region: Tim44; cl09208 1111678002028 Protein of unknown function (DUF1294); Region: DUF1294; cl01311 1111678002029 HPr kinase/phosphorylase; Provisional; Region: PRK05428 1111678002030 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 1111678002031 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 1111678002032 Hpr binding site; other site 1111678002033 active site 1111678002034 homohexamer subunit interaction site [polypeptide binding]; other site 1111678002035 Prolipoprotein diacylglyceryl transferase; Region: LGT; pfam01790 1111678002036 Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768 1111678002037 YtxH-like protein; Region: YtxH; cl02079 1111678002038 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 1111678002039 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 1111678002040 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 1111678002041 K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158 1111678002042 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1111678002043 K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158 1111678002044 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1111678002045 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1111678002046 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1111678002047 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 1111678002048 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1111678002049 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_4; cd03407 1111678002050 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1111678002051 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1111678002052 non-specific DNA binding site [nucleotide binding]; other site 1111678002053 salt bridge; other site 1111678002054 sequence-specific DNA binding site [nucleotide binding]; other site 1111678002055 Lactococcus bacteriophage repressor; Region: Lac_bphage_repr; pfam06543 1111678002056 ribonuclease Z; Region: RNase_Z; TIGR02651 1111678002057 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1111678002058 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1111678002059 NAD(P) binding site [chemical binding]; other site 1111678002060 active site 1111678002061 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 1111678002062 DHH family; Region: DHH; pfam01368 1111678002063 DHHA1 domain; Region: DHHA1; pfam02272 1111678002064 Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; cl11538 1111678002065 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1111678002066 active site 1111678002067 DNA-directed RNA polymerase, delta subunit [Transcription]; Region: RpoE; COG3343 1111678002068 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 1111678002069 dimerization interface [polypeptide binding]; other site 1111678002070 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1111678002071 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1111678002072 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1111678002073 HTH-like domain; Region: HTH_21; pfam13276 1111678002074 Integrase core domain; Region: rve; pfam00665 1111678002075 Integrase core domain; Region: rve_2; pfam13333 1111678002076 putative transposase OrfB; Reviewed; Region: PHA02517 1111678002077 HTH-like domain; Region: HTH_21; pfam13276 1111678002078 Integrase core domain; Region: rve; pfam00665 1111678002079 Integrase core domain; Region: rve_3; pfam13683 1111678002080 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1111678002081 Transposase; Region: HTH_Tnp_1; pfam01527 1111678002082 Transcriptional repressor of class III stress genes [Transcription]; Region: CtsR; COG4463 1111678002083 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 1111678002084 Clp amino terminal domain; Region: Clp_N; pfam02861 1111678002085 Clp amino terminal domain; Region: Clp_N; pfam02861 1111678002086 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1111678002087 Walker A motif; other site 1111678002088 ATP binding site [chemical binding]; other site 1111678002089 Walker B motif; other site 1111678002090 arginine finger; other site 1111678002091 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1111678002092 Walker A motif; other site 1111678002093 ATP binding site [chemical binding]; other site 1111678002094 Walker B motif; other site 1111678002095 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1111678002096 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1111678002097 30S subunit binding site; other site 1111678002098 enolase; Provisional; Region: eno; PRK00077 1111678002099 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1111678002100 dimer interface [polypeptide binding]; other site 1111678002101 metal binding site [ion binding]; metal-binding site 1111678002102 substrate binding pocket [chemical binding]; other site 1111678002103 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1111678002104 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1111678002105 Walker A/P-loop; other site 1111678002106 ATP binding site [chemical binding]; other site 1111678002107 Q-loop/lid; other site 1111678002108 ABC transporter signature motif; other site 1111678002109 Walker B; other site 1111678002110 D-loop; other site 1111678002111 H-loop/switch region; other site 1111678002112 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1111678002113 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1111678002114 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1111678002115 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 1111678002116 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1111678002117 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1111678002118 acyl-activating enzyme (AAE) consensus motif; other site 1111678002119 acyl-activating enzyme (AAE) consensus motif; other site 1111678002120 AMP binding site [chemical binding]; other site 1111678002121 active site 1111678002122 CoA binding site [chemical binding]; other site 1111678002123 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 1111678002124 Cl binding site [ion binding]; other site 1111678002125 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 1111678002126 oligomer interface [polypeptide binding]; other site 1111678002127 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 1111678002128 Pyruvate formate lyase 1; Region: PFL1; cd01678 1111678002129 coenzyme A binding site [chemical binding]; other site 1111678002130 active site 1111678002131 catalytic residues [active] 1111678002132 glycine loop; other site 1111678002133 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 1111678002134 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1111678002135 CoA-binding site [chemical binding]; other site 1111678002136 ATP-binding [chemical binding]; other site 1111678002137 drug efflux system protein MdtG; Provisional; Region: PRK09874 1111678002138 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1111678002139 putative substrate translocation pore; other site 1111678002140 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1111678002141 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 1111678002142 Pyruvate carboxylase [Energy production and conversion]; Region: PycA; COG1038 1111678002143 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1111678002144 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1111678002145 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1111678002146 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 1111678002147 active site 1111678002148 catalytic residues [active] 1111678002149 metal binding site [ion binding]; metal-binding site 1111678002150 homodimer binding site [polypeptide binding]; other site 1111678002151 Conserved carboxylase domain; Region: PYC_OADA; pfam02436 1111678002152 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1111678002153 carboxyltransferase (CT) interaction site; other site 1111678002154 biotinylation site [posttranslational modification]; other site 1111678002155 Similar to citrate synthase (si) (EC 2.3.3.1); predicted non-functional due to G to T conversion leading to TAA stop 1111678002156 aconitate hydratase; Validated; Region: PRK09277 1111678002157 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 1111678002158 substrate binding site [chemical binding]; other site 1111678002159 ligand binding site [chemical binding]; other site 1111678002160 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 1111678002161 substrate binding site [chemical binding]; other site 1111678002162 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 1111678002163 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1111678002164 oligomer interface [polypeptide binding]; other site 1111678002165 active site residues [active] 1111678002166 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 1111678002167 putative catalytic residues [active] 1111678002168 thiol/disulfide switch; other site 1111678002169 Similar to cation-transporting ATPase; predicted non-functional due to frameshift 1111678002170 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1111678002171 Transposase; Region: HTH_Tnp_1; pfam01527 1111678002172 Similar to transposase of IS981D; predicted non-functional due to frameshift 1111678002173 Similar to glycosyltransferase; predicted non-functional due to transposon insertion 1111678002174 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1111678002175 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1111678002176 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 1111678002177 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 1111678002178 Predicted acetyltransferase [General function prediction only]; Region: COG2388 1111678002179 Uncharacterized conserved protein [Function unknown]; Region: COG3592 1111678002180 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1111678002181 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 1111678002182 active site 1111678002183 topology modulation protein; Reviewed; Region: PRK08118 1111678002184 AAA domain; Region: AAA_17; pfam13207 1111678002185 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 1111678002186 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 1111678002187 putative active site [active] 1111678002188 putative metal binding site [ion binding]; other site 1111678002189 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 1111678002190 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1111678002191 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 1111678002192 S-adenosylmethionine binding site [chemical binding]; other site 1111678002193 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1111678002194 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1111678002195 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1111678002196 active site 1111678002197 elongation factor P; Validated; Region: PRK00529 1111678002198 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1111678002199 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1111678002200 RNA binding site [nucleotide binding]; other site 1111678002201 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1111678002202 RNA binding site [nucleotide binding]; other site 1111678002203 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 1111678002204 putative RNA binding site [nucleotide binding]; other site 1111678002205 Transcription termination factor [Transcription]; Region: NusB; COG0781 1111678002206 Similar to 4-alpha-glucanotransferase (amylomaltase) (EC 2.4.1.25); predicted non-functional due to C to A conversion leading to TAA stop 1111678002207 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 1111678002208 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 1111678002209 ligand binding site; other site 1111678002210 oligomer interface; other site 1111678002211 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 1111678002212 dimer interface [polypeptide binding]; other site 1111678002213 N-terminal domain interface [polypeptide binding]; other site 1111678002214 sulfate 1 binding site; other site 1111678002215 glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092 1111678002216 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 1111678002217 ligand binding site; other site 1111678002218 oligomer interface; other site 1111678002219 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 1111678002220 dimer interface [polypeptide binding]; other site 1111678002221 N-terminal domain interface [polypeptide binding]; other site 1111678002222 sulfate 1 binding site; other site 1111678002223 glycogen synthase; Provisional; Region: glgA; PRK00654 1111678002224 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 1111678002225 ADP-binding pocket [chemical binding]; other site 1111678002226 homodimer interface [polypeptide binding]; other site 1111678002227 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 1111678002228 active site 1111678002229 homodimer interface [polypeptide binding]; other site 1111678002230 catalytic site [active] 1111678002231 COMC family; Region: ComC; pfam03047 1111678002232 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1111678002233 non-specific DNA binding site [nucleotide binding]; other site 1111678002234 salt bridge; other site 1111678002235 sequence-specific DNA binding site [nucleotide binding]; other site 1111678002236 Predicted metal-dependent membrane protease [General function prediction only]; Region: COG1266 1111678002237 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 1111678002238 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1111678002239 putative substrate translocation pore; other site 1111678002240 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1111678002241 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1111678002242 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1111678002243 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 1111678002244 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1111678002245 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1111678002246 Walker A/P-loop; other site 1111678002247 ATP binding site [chemical binding]; other site 1111678002248 Q-loop/lid; other site 1111678002249 ABC transporter signature motif; other site 1111678002250 Walker B; other site 1111678002251 D-loop; other site 1111678002252 H-loop/switch region; other site 1111678002253 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 1111678002254 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1111678002255 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1111678002256 Walker A/P-loop; other site 1111678002257 ATP binding site [chemical binding]; other site 1111678002258 Q-loop/lid; other site 1111678002259 ABC transporter signature motif; other site 1111678002260 Walker B; other site 1111678002261 D-loop; other site 1111678002262 H-loop/switch region; other site 1111678002263 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1111678002264 putative DNA binding site [nucleotide binding]; other site 1111678002265 putative Zn2+ binding site [ion binding]; other site 1111678002266 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 1111678002267 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 1111678002268 L27 domain; Region: L27; cl02672 1111678002269 Similar to putative flavodoxin; predicted non-functional due to TAG stop codon 1111678002270 NnaC (CMP-NeuNAc synthetase) _like subfamily of SGNH_hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: NnaC_like; cd01841 1111678002271 active site 1111678002272 catalytic triad [active] 1111678002273 oxyanion hole [active] 1111678002274 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 1111678002275 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1111678002276 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1111678002277 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1111678002278 Walker A/P-loop; other site 1111678002279 ATP binding site [chemical binding]; other site 1111678002280 Q-loop/lid; other site 1111678002281 ABC transporter signature motif; other site 1111678002282 Walker B; other site 1111678002283 D-loop; other site 1111678002284 H-loop/switch region; other site 1111678002285 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1111678002286 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 1111678002287 FtsX-like permease family; Region: FtsX; pfam02687 1111678002288 Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082); Region: DUF2082; pfam09855 1111678002289 Predicted membrane protein [Function unknown]; Region: COG3619 1111678002290 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 1111678002291 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 1111678002292 putative NAD(P) binding site [chemical binding]; other site 1111678002293 dimer interface [polypeptide binding]; other site 1111678002294 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1111678002295 substrate binding site [chemical binding]; other site 1111678002296 THF binding site; other site 1111678002297 zinc-binding site [ion binding]; other site 1111678002298 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1111678002299 DNA-binding site [nucleotide binding]; DNA binding site 1111678002300 RNA-binding motif; other site 1111678002301 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1111678002302 DNA-binding site [nucleotide binding]; DNA binding site 1111678002303 RNA-binding motif; other site 1111678002304 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 1111678002305 Similar to hypothetical protein; predicted non-functional due to frameshift 1111678002306 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1111678002307 nucleoside/Zn binding site; other site 1111678002308 dimer interface [polypeptide binding]; other site 1111678002309 catalytic motif [active] 1111678002310 Similar to ABC-type polysaccharide transport system, permease component; predicted non-functional due to C to A conversion leading to TAA stop 1111678002311 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1111678002312 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1111678002313 dimer interface [polypeptide binding]; other site 1111678002314 conserved gate region; other site 1111678002315 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1111678002316 ABC-ATPase subunit interface; other site 1111678002317 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1111678002318 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1111678002319 Protein of unknown function, DUF624; Region: DUF624; pfam04854 1111678002320 Similar to Maltodextrin glucosidase (EC 3.2.1.20); predicted non-functional due to frameshift 1111678002321 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1111678002322 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1111678002323 DNA binding site [nucleotide binding] 1111678002324 domain linker motif; other site 1111678002325 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1111678002326 dimerization interface [polypeptide binding]; other site 1111678002327 ligand binding site [chemical binding]; other site 1111678002328 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1111678002329 CoenzymeA binding site [chemical binding]; other site 1111678002330 subunit interaction site [polypeptide binding]; other site 1111678002331 PHB binding site; other site 1111678002332 N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317 1111678002333 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 1111678002334 active site 1111678002335 octamer interface [polypeptide binding]; other site 1111678002336 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 1111678002337 O-succinylbenzoate-CoA ligase; Region: menE; TIGR01923 1111678002338 acyl-activating enzyme (AAE) consensus motif; other site 1111678002339 putative AMP binding site [chemical binding]; other site 1111678002340 putative active site [active] 1111678002341 putative CoA binding site [chemical binding]; other site 1111678002342 dihydroxynaphthoic acid synthetase; Validated; Region: PRK07396 1111678002343 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1111678002344 substrate binding site [chemical binding]; other site 1111678002345 oxyanion hole (OAH) forming residues; other site 1111678002346 trimer interface [polypeptide binding]; other site 1111678002347 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 1111678002348 Putative lysophospholipase; Region: Hydrolase_4; cl19140 1111678002349 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase [Coenzyme metabolism]; Region: MenD; COG1165 1111678002350 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 1111678002351 dimer interface [polypeptide binding]; other site 1111678002352 tetramer interface [polypeptide binding]; other site 1111678002353 PYR/PP interface [polypeptide binding]; other site 1111678002354 TPP binding site [chemical binding]; other site 1111678002355 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 1111678002356 TPP-binding site; other site 1111678002357 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 1111678002358 chorismate binding enzyme; Region: Chorismate_bind; cl10555 1111678002359 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1111678002360 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1111678002361 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 1111678002362 DRTGG domain; Region: DRTGG; pfam07085 1111678002363 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 1111678002364 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 1111678002365 DHH family; Region: DHH; pfam01368 1111678002366 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 1111678002367 active site 1111678002368 homodimer interface [polypeptide binding]; other site 1111678002369 homotetramer interface [polypeptide binding]; other site 1111678002370 Similar to hydrolase (HAD superfamily); predicted non-functional due to GTCTTTCCATC insertion 1111678002371 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 1111678002372 Flotillin or reggie family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_flotillin; cd03399 1111678002373 aspartate kinase; Reviewed; Region: PRK09034 1111678002374 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 1111678002375 nucleotide binding site [chemical binding]; other site 1111678002376 substrate binding site [chemical binding]; other site 1111678002377 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 1111678002378 allosteric regulatory residue; other site 1111678002379 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 1111678002380 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1111678002381 Patatin-like phospholipase; Region: Patatin; pfam01734 1111678002382 active site 1111678002383 nucleophile elbow; other site 1111678002384 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1111678002385 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 1111678002386 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 1111678002387 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1111678002388 active site 1111678002389 motif I; other site 1111678002390 motif II; other site 1111678002391 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 1111678002392 DHH family; Region: DHH; pfam01368 1111678002393 DHHA1 domain; Region: DHHA1; pfam02272 1111678002394 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1111678002395 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1111678002396 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1111678002397 replicative DNA helicase; Provisional; Region: PRK05748 1111678002398 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1111678002399 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1111678002400 Walker A motif; other site 1111678002401 ATP binding site [chemical binding]; other site 1111678002402 Walker B motif; other site 1111678002403 DNA binding loops [nucleotide binding] 1111678002404 Uncharacterized protein conserved in bacteria [Function unknown]; Region: Veg; COG4466 1111678002405 Thiamine kinase and related kinases [Coenzyme transport and metabolism]; Region: ycfN; COG0510 1111678002406 Phosphotransferase enzyme family; Region: APH; pfam01636 1111678002407 active site 1111678002408 ATP binding site [chemical binding]; other site 1111678002409 substrate binding site [chemical binding]; other site 1111678002410 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1111678002411 S-adenosylmethionine binding site [chemical binding]; other site 1111678002412 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 1111678002413 C-terminal zinc ribbon domain of RNA polymerase intrinsic transcript cleavage subunit; Region: Zn-ribbon; cl02609 1111678002414 ATP cone domain; Region: ATP-cone; pfam03477 1111678002415 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 1111678002416 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 1111678002417 primosomal protein DnaI; Reviewed; Region: PRK08939 1111678002418 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 1111678002419 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1111678002420 Walker A motif; other site 1111678002421 ATP binding site [chemical binding]; other site 1111678002422 Walker B motif; other site 1111678002423 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 1111678002424 dimer interface [polypeptide binding]; other site 1111678002425 FMN binding site [chemical binding]; other site 1111678002426 NADPH bind site [chemical binding]; other site 1111678002427 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1111678002428 GTP-binding protein Der; Reviewed; Region: PRK00093 1111678002429 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1111678002430 G1 box; other site 1111678002431 GTP/Mg2+ binding site [chemical binding]; other site 1111678002432 Switch I region; other site 1111678002433 G2 box; other site 1111678002434 Switch II region; other site 1111678002435 G3 box; other site 1111678002436 G4 box; other site 1111678002437 G5 box; other site 1111678002438 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1111678002439 G1 box; other site 1111678002440 GTP/Mg2+ binding site [chemical binding]; other site 1111678002441 Switch I region; other site 1111678002442 G2 box; other site 1111678002443 G3 box; other site 1111678002444 Switch II region; other site 1111678002445 G4 box; other site 1111678002446 G5 box; other site 1111678002447 Similar to transcriptional regulator; predicted non-functional due to transposon insertion 1111678002448 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1111678002449 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1111678002450 Similar to Sortase A, LPXTG specific; predicted non-functional due to TAA stop codon 1111678002451 Similar to hypothetical protein; predicted non-functional due to C to T conversion leading to TAA stop 1111678002452 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 1111678002453 Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380 1111678002454 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 1111678002455 putative oligomer interface [polypeptide binding]; other site 1111678002456 putative RNA binding site [nucleotide binding]; other site 1111678002457 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 1111678002458 NusA N-terminal domain; Region: NusA_N; pfam08529 1111678002459 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1111678002460 RNA binding site [nucleotide binding]; other site 1111678002461 homodimer interface [polypeptide binding]; other site 1111678002462 NusA-like KH domain; Region: KH_5; pfam13184 1111678002463 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1111678002464 G-X-X-G motif; other site 1111678002465 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 1111678002466 putative RNA binding cleft [nucleotide binding]; other site 1111678002467 hypothetical protein; Provisional; Region: PRK07283 1111678002468 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1111678002469 DNA polymerase III subunits tau domain IV DnaB-binding; Region: DNA_pol3_tau_4; pfam12168 1111678002470 translation initiation factor IF-2; Validated; Region: infB; PRK05306 1111678002471 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1111678002472 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1111678002473 G1 box; other site 1111678002474 putative GEF interaction site [polypeptide binding]; other site 1111678002475 GTP/Mg2+ binding site [chemical binding]; other site 1111678002476 Switch I region; other site 1111678002477 G2 box; other site 1111678002478 G3 box; other site 1111678002479 Switch II region; other site 1111678002480 G4 box; other site 1111678002481 G5 box; other site 1111678002482 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1111678002483 Translation-initiation factor 2; Region: IF-2; pfam11987 1111678002484 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1111678002485 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1111678002486 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 1111678002487 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl19057 1111678002488 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1111678002489 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 1111678002490 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 1111678002491 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1111678002492 dimer interface [polypeptide binding]; other site 1111678002493 active site 1111678002494 CoA binding pocket [chemical binding]; other site 1111678002495 acyl carrier protein; Provisional; Region: acpP; PRK00982 1111678002496 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1111678002497 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1111678002498 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1111678002499 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 1111678002500 NAD(P) binding site [chemical binding]; other site 1111678002501 homotetramer interface [polypeptide binding]; other site 1111678002502 homodimer interface [polypeptide binding]; other site 1111678002503 active site 1111678002504 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 1111678002505 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1111678002506 dimer interface [polypeptide binding]; other site 1111678002507 active site 1111678002508 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 1111678002509 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1111678002510 carboxyltransferase (CT) interaction site; other site 1111678002511 biotinylation site [posttranslational modification]; other site 1111678002512 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1111678002513 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1111678002514 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1111678002515 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1111678002516 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1111678002517 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 1111678002518 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; COG0825 1111678002519 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1111678002520 homodimer interface [polypeptide binding]; other site 1111678002521 substrate-cofactor binding pocket; other site 1111678002522 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1111678002523 catalytic residue [active] 1111678002524 cysteine synthase; Region: PLN02565 1111678002525 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1111678002526 dimer interface [polypeptide binding]; other site 1111678002527 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1111678002528 catalytic residue [active] 1111678002529 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237 1111678002530 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1111678002531 active site residue [active] 1111678002532 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 1111678002533 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 1111678002534 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1111678002535 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 1111678002536 Member of the Rhodanese Homology Domain superfamily. Included in this CD are the Lactococcus lactis NADH oxidase, Bacillus cereus NADH dehydrogenase, and Bacteroides thetaiotaomicron pyridine nucleotide-disulphide oxidoreductase, and similar...; Region: RHOD_Pyr_redox; cd01524 1111678002537 active site residue [active] 1111678002538 Uncharacterized protein YrkD from Bacillus subtilis and related domains; this domain superfamily was previously known as part of DUF156; Region: BsYrkD-like_DUF156; cd10155 1111678002539 putative homodimer interface [polypeptide binding]; other site 1111678002540 putative homotetramer interface [polypeptide binding]; other site 1111678002541 putative metal binding site [ion binding]; other site 1111678002542 putative homodimer-homodimer interface [polypeptide binding]; other site 1111678002543 putative allosteric switch controlling residues; other site 1111678002544 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 1111678002545 putative ArsC-like catalytic residues; other site 1111678002546 putative TRX-like catalytic residues [active] 1111678002547 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1111678002548 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 1111678002549 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1111678002550 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1111678002551 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1111678002552 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 1111678002553 active site 1111678002554 putative catalytic site [active] 1111678002555 DNA binding site [nucleotide binding] 1111678002556 putative phosphate binding site [ion binding]; other site 1111678002557 metal binding site A [ion binding]; metal-binding site 1111678002558 AP binding site [nucleotide binding]; other site 1111678002559 metal binding site B [ion binding]; metal-binding site 1111678002560 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 1111678002561 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1111678002562 active site 1111678002563 HIGH motif; other site 1111678002564 KMSKS motif; other site 1111678002565 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1111678002566 tRNA binding surface [nucleotide binding]; other site 1111678002567 anticodon binding site; other site 1111678002568 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 1111678002569 dimer interface [polypeptide binding]; other site 1111678002570 putative tRNA-binding site [nucleotide binding]; other site 1111678002571 Protein of unknown function (DUF2829); Region: DUF2829; pfam11195 1111678002572 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK06550 1111678002573 classical (c) SDRs; Region: SDR_c; cd05233 1111678002574 NAD(P) binding site [chemical binding]; other site 1111678002575 active site 1111678002576 Predicted membrane protein [Function unknown]; Region: COG4708 1111678002577 Similar to Rrf2-linked NADH-flavin reductase; predicted non-functional due to G to T conversion leading to TAA stop 1111678002578 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1111678002579 Transposase; Region: HTH_Tnp_1; pfam01527 1111678002580 putative transposase OrfB; Reviewed; Region: PHA02517 1111678002581 HTH-like domain; Region: HTH_21; pfam13276 1111678002582 Integrase core domain; Region: rve; pfam00665 1111678002583 Integrase core domain; Region: rve_3; pfam13683 1111678002584 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1111678002585 Helix-turn-helix domain; Region: HTH_28; pfam13518 1111678002586 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1111678002587 Transposase; Region: HTH_Tnp_1; cl17663 1111678002588 putative transposase OrfB; Reviewed; Region: PHA02517 1111678002589 HTH-like domain; Region: HTH_21; pfam13276 1111678002590 Integrase core domain; Region: rve; pfam00665 1111678002591 Integrase core domain; Region: rve_2; pfam13333 1111678002592 putative transposase OrfB; Reviewed; Region: PHA02517 1111678002593 HTH-like domain; Region: HTH_21; pfam13276 1111678002594 Integrase core domain; Region: rve; pfam00665 1111678002595 Integrase core domain; Region: rve_3; pfam13683 1111678002596 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1111678002597 Transposase; Region: HTH_Tnp_1; pfam01527 1111678002598 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 1111678002599 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118 1111678002600 Semialdehyde dehydrogenase, dimerization domain; Region: Semialdhyde_dhC; pfam02774 1111678002601 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 1111678002602 heterotetramer interface [polypeptide binding]; other site 1111678002603 active site pocket [active] 1111678002604 cleavage site 1111678002605 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1111678002606 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 1111678002607 inhibitor-cofactor binding pocket; inhibition site 1111678002608 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1111678002609 catalytic residue [active] 1111678002610 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 1111678002611 feedback inhibition sensing region; other site 1111678002612 homohexameric interface [polypeptide binding]; other site 1111678002613 nucleotide binding site [chemical binding]; other site 1111678002614 N-acetyl-L-glutamate binding site [chemical binding]; other site 1111678002615 ornithine carbamoyltransferase; Validated; Region: PRK02102 1111678002616 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1111678002617 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1111678002618 ribonuclease III; Reviewed; Region: rnc; PRK00102 1111678002619 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1111678002620 dimerization interface [polypeptide binding]; other site 1111678002621 active site 1111678002622 metal binding site [ion binding]; metal-binding site 1111678002623 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1111678002624 dsRNA binding site [nucleotide binding]; other site 1111678002625 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1111678002626 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1111678002627 Walker A/P-loop; other site 1111678002628 ATP binding site [chemical binding]; other site 1111678002629 Q-loop/lid; other site 1111678002630 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 1111678002631 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 1111678002632 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1111678002633 Q-loop/lid; other site 1111678002634 ABC transporter signature motif; other site 1111678002635 Walker B; other site 1111678002636 D-loop; other site 1111678002637 H-loop/switch region; other site 1111678002638 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1111678002639 Sulfatase; Region: Sulfatase; cl19157 1111678002640 Predicted multitransmembrane protein [Function unknown]; Region: COG5438 1111678002641 Predicted multitransmembrane protein [Function unknown]; Region: COG5438 1111678002642 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1111678002643 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1111678002644 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1111678002645 active site 1111678002646 motif I; other site 1111678002647 motif II; other site 1111678002648 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 1111678002649 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 1111678002650 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 1111678002651 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 1111678002652 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1111678002653 P loop; other site 1111678002654 GTP binding site [chemical binding]; other site 1111678002655 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02269 1111678002656 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1111678002657 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1111678002658 active site 1111678002659 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1111678002660 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1111678002661 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1111678002662 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1111678002663 HIGH motif; other site 1111678002664 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1111678002665 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1111678002666 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1111678002667 active site 1111678002668 KMSKS motif; other site 1111678002669 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1111678002670 tRNA binding surface [nucleotide binding]; other site 1111678002671 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1111678002672 Similar to phosphosugar-binding transcriptional regulator, RpiR family; predicted non-functional due to frameshift 1111678002673 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 1111678002674 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 1111678002675 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1111678002676 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1111678002677 Putative lysophospholipase; Region: Hydrolase_4; cl19140 1111678002678 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1111678002679 Transposase; Region: HTH_Tnp_1; pfam01527 1111678002680 putative transposase OrfB; Reviewed; Region: PHA02517 1111678002681 HTH-like domain; Region: HTH_21; pfam13276 1111678002682 Integrase core domain; Region: rve; pfam00665 1111678002683 Integrase core domain; Region: rve_3; pfam13683 1111678002684 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1111678002685 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1111678002686 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1111678002687 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1111678002688 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 1111678002689 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1111678002690 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 1111678002691 putative L-serine binding site [chemical binding]; other site 1111678002692 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 1111678002693 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 1111678002694 Predicted transcriptional regulator [Transcription]; Region: COG3682 1111678002695 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1111678002696 metal-binding site [ion binding] 1111678002697 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1111678002698 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1111678002699 metal-binding site [ion binding] 1111678002700 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1111678002701 Predicted membrane protein [Function unknown]; Region: COG4485 1111678002702 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 1111678002703 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 1111678002704 nucleotide binding site/active site [active] 1111678002705 HIT family signature motif; other site 1111678002706 catalytic residue [active] 1111678002707 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 1111678002708 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1111678002709 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 1111678002710 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 1111678002711 RNA binding site [nucleotide binding]; other site 1111678002712 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1111678002713 RNA binding site [nucleotide binding]; other site 1111678002714 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 1111678002715 RNA binding site [nucleotide binding]; other site 1111678002716 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 1111678002717 RNA binding site [nucleotide binding]; other site 1111678002718 Fibronectin-binding repeat; Region: SSURE; pfam11966 1111678002719 Fibronectin-binding repeat; Region: SSURE; pfam11966 1111678002720 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1111678002721 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1111678002722 active site 1111678002723 phosphorylation site [posttranslational modification] 1111678002724 intermolecular recognition site; other site 1111678002725 dimerization interface [polypeptide binding]; other site 1111678002726 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1111678002727 DNA binding site [nucleotide binding] 1111678002728 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1111678002729 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1111678002730 dimer interface [polypeptide binding]; other site 1111678002731 phosphorylation site [posttranslational modification] 1111678002732 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1111678002733 ATP binding site [chemical binding]; other site 1111678002734 Mg2+ binding site [ion binding]; other site 1111678002735 G-X-G motif; other site 1111678002736 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 1111678002737 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 1111678002738 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1111678002739 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1111678002740 GIY-YIG motif/motif A; other site 1111678002741 active site 1111678002742 catalytic site [active] 1111678002743 putative DNA binding site [nucleotide binding]; other site 1111678002744 metal binding site [ion binding]; metal-binding site 1111678002745 UvrB/uvrC motif; Region: UVR; pfam02151 1111678002746 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1111678002747 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 1111678002748 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 1111678002749 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1111678002750 minor groove reading motif; other site 1111678002751 helix-hairpin-helix signature motif; other site 1111678002752 substrate binding pocket [chemical binding]; other site 1111678002753 active site 1111678002754 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 1111678002755 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 1111678002756 DNA binding and oxoG recognition site [nucleotide binding] 1111678002757 accessory Sec system translocase SecA2; Region: secA2; TIGR03714 1111678002758 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 1111678002759 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1111678002760 nucleotide binding region [chemical binding]; other site 1111678002761 ATP-binding site [chemical binding]; other site 1111678002762 SecA Wing and Scaffold domain; Region: SecA_SW; pfam07516 1111678002763 Similar to beta-1,6-galactofuranosyltransferase; predicted non-functional due to TAA stop codon 1111678002764 Similar to Poly(glycerol-phosphate) alpha-glucosyltransferase GftA (EC 2.4.1.52); predicted non-functional due to transposon insertion 1111678002765 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1111678002766 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1111678002767 Similar to glycosyltransferase; predicted non-functional due to transposon insertion 1111678002768 Integrase core domain; Region: rve; pfam00665 1111678002769 DDE domain; Region: DDE_Tnp_IS240; pfam13610 1111678002770 Integrase core domain; Region: rve_3; pfam13683 1111678002771 glycosyltransferase, SP_1767 family; Region: glyco_access_1; TIGR03728 1111678002772 dipeptidase PepV; Region: dipeptidase; TIGR01886 1111678002773 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 1111678002774 active site 1111678002775 metal binding site [ion binding]; metal-binding site 1111678002776 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 1111678002777 alanine racemase; Reviewed; Region: alr; PRK00053 1111678002778 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1111678002779 active site 1111678002780 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1111678002781 dimer interface [polypeptide binding]; other site 1111678002782 substrate binding site [chemical binding]; other site 1111678002783 catalytic residues [active] 1111678002784 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 1111678002785 ArsC family; Region: ArsC; pfam03960 1111678002786 putative catalytic residues [active] 1111678002787 thiol/disulfide switch; other site 1111678002788 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 1111678002789 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1111678002790 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 1111678002791 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1111678002792 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1111678002793 Walker A/P-loop; other site 1111678002794 ATP binding site [chemical binding]; other site 1111678002795 Q-loop/lid; other site 1111678002796 ABC transporter signature motif; other site 1111678002797 Walker B; other site 1111678002798 D-loop; other site 1111678002799 H-loop/switch region; other site 1111678002800 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 1111678002801 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1111678002802 dimer interface [polypeptide binding]; other site 1111678002803 conserved gate region; other site 1111678002804 putative PBP binding loops; other site 1111678002805 ABC-ATPase subunit interface; other site 1111678002806 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 1111678002807 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1111678002808 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1111678002809 Similar to Lead, cadmium, zinc and mercury transporting ATPase; Copper-translocating P-type ATPase; predicted non-functional due to G to A conversion leading to TAG stop codon 1111678002810 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14179 1111678002811 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1111678002812 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1111678002813 homodimer interface [polypeptide binding]; other site 1111678002814 NADP binding site [chemical binding]; other site 1111678002815 substrate binding site [chemical binding]; other site 1111678002816 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 1111678002817 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1111678002818 generic binding surface II; other site 1111678002819 generic binding surface I; other site 1111678002820 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 1111678002821 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1111678002822 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1111678002823 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 1111678002824 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1111678002825 substrate binding pocket [chemical binding]; other site 1111678002826 chain length determination region; other site 1111678002827 substrate-Mg2+ binding site; other site 1111678002828 catalytic residues [active] 1111678002829 aspartate-rich region 1; other site 1111678002830 active site lid residues [active] 1111678002831 aspartate-rich region 2; other site 1111678002832 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1111678002833 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1111678002834 Coenzyme A binding pocket [chemical binding]; other site 1111678002835 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 1111678002836 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1111678002837 RNA binding surface [nucleotide binding]; other site 1111678002838 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 1111678002839 Arginine repressor [Transcription]; Region: ArgR; COG1438 1111678002840 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1111678002841 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 1111678002842 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1111678002843 Walker A/P-loop; other site 1111678002844 ATP binding site [chemical binding]; other site 1111678002845 Q-loop/lid; other site 1111678002846 ABC transporter signature motif; other site 1111678002847 Walker B; other site 1111678002848 D-loop; other site 1111678002849 H-loop/switch region; other site 1111678002850 Predicted integral membrane protein [Function unknown]; Region: COG3548 1111678002851 Predicted membrane protein [Function unknown]; Region: COG3152 1111678002852 Similar to hypothetical protein; predicted non-functional due to C to T conversion leading to TAA stop 1111678002853 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 1111678002854 Protein required for the initiation of cell division [Cell division and chromosome partitioning]; Region: FtsL; COG4839 1111678002855 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1111678002856 Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717 1111678002857 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1111678002858 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 1111678002859 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 1111678002860 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1111678002861 Mg++ binding site [ion binding]; other site 1111678002862 putative catalytic motif [active] 1111678002863 putative substrate binding site [chemical binding]; other site 1111678002864 Similar to ABC transporter permease protein; predicted non-functional due to G to T conversion leading to TGA stop 1111678002865 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1111678002866 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1111678002867 Walker A/P-loop; other site 1111678002868 ATP binding site [chemical binding]; other site 1111678002869 Q-loop/lid; other site 1111678002870 ABC transporter signature motif; other site 1111678002871 Walker B; other site 1111678002872 D-loop; other site 1111678002873 H-loop/switch region; other site 1111678002874 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1111678002875 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1111678002876 dimerization interface [polypeptide binding]; other site 1111678002877 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1111678002878 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1111678002879 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1111678002880 synthetase active site [active] 1111678002881 NTP binding site [chemical binding]; other site 1111678002882 metal binding site [ion binding]; metal-binding site 1111678002883 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1111678002884 Similar to putative ketostero isomerase; predicted non-functional due to G to T conversion leading to TAA stop codon 1111678002885 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1111678002886 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1111678002887 Coenzyme A binding pocket [chemical binding]; other site 1111678002888 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1111678002889 N-glycosyltransferase; Provisional; Region: PRK11204 1111678002890 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 1111678002891 DXD motif; other site 1111678002892 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 1111678002893 Nicotinamide mononucleotide transporter; Region: NMN_transporter; cl01256 1111678002894 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1111678002895 Ligand Binding Site [chemical binding]; other site 1111678002896 histone-like DNA-binding protein HU; Region: HU; cd13831 1111678002897 dimer interface [polypeptide binding]; other site 1111678002898 DNA binding site [nucleotide binding] 1111678002899 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 1111678002900 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1111678002901 Similar to phage infection protein; predicted non-functional due to transposon insertion 1111678002902 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1111678002903 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1111678002904 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 1111678002905 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 1111678002906 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1111678002907 active site 1111678002908 DNA binding site [nucleotide binding] 1111678002909 Int/Topo IB signature motif; other site 1111678002910 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1111678002911 Transposase; Region: HTH_Tnp_1; pfam01527 1111678002912 putative transposase OrfB; Reviewed; Region: PHA02517 1111678002913 HTH-like domain; Region: HTH_21; pfam13276 1111678002914 Integrase core domain; Region: rve; pfam00665 1111678002915 Integrase core domain; Region: rve_3; pfam13683 1111678002916 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; cl19753 1111678002917 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1111678002918 Histidine kinase; Region: HisKA_3; pfam07730 1111678002919 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1111678002920 ATP binding site [chemical binding]; other site 1111678002921 Mg2+ binding site [ion binding]; other site 1111678002922 G-X-G motif; other site 1111678002923 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1111678002924 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1111678002925 active site 1111678002926 phosphorylation site [posttranslational modification] 1111678002927 intermolecular recognition site; other site 1111678002928 dimerization interface [polypeptide binding]; other site 1111678002929 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1111678002930 DNA binding residues [nucleotide binding] 1111678002931 dimerization interface [polypeptide binding]; other site 1111678002932 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1111678002933 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1111678002934 active site 1111678002935 motif I; other site 1111678002936 motif II; other site 1111678002937 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 1111678002938 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1111678002939 active site 1111678002940 Predicted RNA binding protein (contains ribosomal protein S1 domain) [Translation, ribosomal structure and biogenesis]; Region: VacB; COG1098 1111678002941 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1111678002942 RNA binding site [nucleotide binding]; other site 1111678002943 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1111678002944 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 1111678002945 Similar to 2,3-butanediol dehydrogenase, R-alcohol forming, (R)- and (S)-acetoin-specific; predicted non-functional due to TGA stop codon 1111678002946 acetoin reductase; Validated; Region: PRK08643 1111678002947 meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366 1111678002948 NAD binding site [chemical binding]; other site 1111678002949 homotetramer interface [polypeptide binding]; other site 1111678002950 homodimer interface [polypeptide binding]; other site 1111678002951 active site 1111678002952 substrate binding site [chemical binding]; other site 1111678002953 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1111678002954 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1111678002955 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1111678002956 ABC transporter; Region: ABC_tran_2; pfam12848 1111678002957 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1111678002958 malate dehydrogenase; Provisional; Region: PRK13529 1111678002959 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1111678002960 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 1111678002961 NAD(P) binding pocket [chemical binding]; other site 1111678002962 2-hydroxycarboxylate transporter family; Region: 2HCT; cl01386 1111678002963 EamA-like transporter family; Region: EamA; pfam00892 1111678002964 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1111678002965 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1111678002966 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1111678002967 Walker A/P-loop; other site 1111678002968 ATP binding site [chemical binding]; other site 1111678002969 Q-loop/lid; other site 1111678002970 ABC transporter signature motif; other site 1111678002971 Walker B; other site 1111678002972 D-loop; other site 1111678002973 H-loop/switch region; other site 1111678002974 Similar to glyoxalase family protein; predicted non-functional due to G to T conversion leading to TAA stop 1111678002975 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1111678002976 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1111678002977 motif II; other site 1111678002978 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 1111678002979 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1111678002980 ATP binding site [chemical binding]; other site 1111678002981 Mg2+ binding site [ion binding]; other site 1111678002982 G-X-G motif; other site 1111678002983 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1111678002984 anchoring element; other site 1111678002985 dimer interface [polypeptide binding]; other site 1111678002986 ATP binding site [chemical binding]; other site 1111678002987 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1111678002988 active site 1111678002989 putative metal-binding site [ion binding]; other site 1111678002990 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1111678002991 Similar to Tn946 Transposase; predicted non-functional due to frameshift 1111678002992 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1111678002993 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1111678002994 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 1111678002995 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1111678002996 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1111678002997 putative substrate translocation pore; other site 1111678002998 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1111678002999 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1111678003000 Exopolysaccharide biosynthesis protein related to N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: EpsL; COG4632 1111678003001 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 1111678003002 putative transposase OrfB; Reviewed; Region: PHA02517 1111678003003 HTH-like domain; Region: HTH_21; pfam13276 1111678003004 Integrase core domain; Region: rve; pfam00665 1111678003005 Integrase core domain; Region: rve_3; pfam13683 1111678003006 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1111678003007 Transposase; Region: HTH_Tnp_1; pfam01527 1111678003008 Domain of unknown function (DUF4422); Region: DUF4422; pfam14393 1111678003009 Lipopolysaccharide biosynthesis proteins, LPS:glycosyltransferases [Cell envelope biogenesis, outer membrane]; Region: RfaJ; COG1442 1111678003010 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 1111678003011 Ligand binding site; other site 1111678003012 metal-binding site 1111678003013 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1111678003014 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1111678003015 Similar to CDP-glycerol:poly(glycerophosphate) glycerophosphotransferase; predicted non-functional due to transposon insertion 1111678003016 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1111678003017 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 1111678003018 Similar to Cell envelope-associated transcriptional attenuator LytR-CpsA-Psr, subfamily F4; predicted non-functional due to frameshift 1111678003019 phosphopentomutase; Provisional; Region: PRK05362 1111678003020 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 1111678003021 Putative zinc ribbon domain; Region: Zn_ribbon_2; pfam12674 1111678003022 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 1111678003023 Similar to secreted protein; predicted non-functional due to C to A conversion leading to TAA stop 1111678003024 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 1111678003025 hypothetical protein; Provisional; Region: PRK00967 1111678003026 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 1111678003027 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 1111678003028 Potassium binding sites [ion binding]; other site 1111678003029 Cesium cation binding sites [ion binding]; other site 1111678003030 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1111678003031 NlpC/P60 family; Region: NLPC_P60; pfam00877 1111678003032 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1111678003033 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1111678003034 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1111678003035 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1111678003036 substrate binding pocket [chemical binding]; other site 1111678003037 membrane-bound complex binding site; other site 1111678003038 hinge residues; other site 1111678003039 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 1111678003040 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1111678003041 dimer interface [polypeptide binding]; other site 1111678003042 conserved gate region; other site 1111678003043 putative PBP binding loops; other site 1111678003044 ABC-ATPase subunit interface; other site 1111678003045 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1111678003046 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1111678003047 Walker A/P-loop; other site 1111678003048 ATP binding site [chemical binding]; other site 1111678003049 Q-loop/lid; other site 1111678003050 ABC transporter signature motif; other site 1111678003051 Walker B; other site 1111678003052 D-loop; other site 1111678003053 H-loop/switch region; other site 1111678003054 Protein of unknown function (DUF4059); Region: DUF4059; pfam13268 1111678003055 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1111678003056 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 1111678003057 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1111678003058 Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314 1111678003059 ribonuclease R; Region: RNase_R; TIGR02063 1111678003060 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 1111678003061 RNB domain; Region: RNB; pfam00773 1111678003062 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 1111678003063 RNA binding site [nucleotide binding]; other site 1111678003064 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1111678003065 catalytic triad [active] 1111678003066 conserved cis-peptide bond; other site 1111678003067 Endonuclease/Exonuclease/phosphatase family; Region: Exo_endo_phos; pfam03372 1111678003068 putative catalytic site [active] 1111678003069 putative metal binding site [ion binding]; other site 1111678003070 putative phosphate binding site [ion binding]; other site 1111678003071 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1111678003072 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1111678003073 1,4-Dihydroxy-2-naphthoate octaprenyltransferase; Region: PT_UbiA_UBIAD1; cd13962 1111678003074 putative active site [active] 1111678003075 Similar to transposase for insertion sequence element IS946; predicted non-functional due to frameshift 1111678003076 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 1111678003077 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 1111678003078 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1111678003079 catalytic core [active] 1111678003080 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1111678003081 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 1111678003082 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 1111678003083 Transcriptional regulator of heat shock gene [Transcription]; Region: HrcA; COG1420 1111678003084 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 1111678003085 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 1111678003086 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1111678003087 dimer interface [polypeptide binding]; other site 1111678003088 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1111678003089 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1111678003090 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 1111678003091 nucleotide binding site [chemical binding]; other site 1111678003092 NEF interaction site [polypeptide binding]; other site 1111678003093 SBD interface [polypeptide binding]; other site 1111678003094 6-pyruvoyl-tetrahydropterin synthase related domain; membrane protein; Region: PTPS_related; pfam10131 1111678003095 Myosin-crossreactive antigen [Function unknown]; Region: COG4716 1111678003096 myosin-cross-reactive antigen; Provisional; Region: PRK13977 1111678003097 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1111678003098 M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669 1111678003099 metal binding site [ion binding]; metal-binding site 1111678003100 dimer interface [polypeptide binding]; other site 1111678003101 Similar to transcriptional repressor of the fructose operon, DeoR family; predicted non-functional due to TAA stop codon 1111678003102 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1111678003103 putative substrate binding site [chemical binding]; other site 1111678003104 putative ATP binding site [chemical binding]; other site 1111678003105 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 1111678003106 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1111678003107 active site 1111678003108 phosphorylation site [posttranslational modification] 1111678003109 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1111678003110 active site 1111678003111 P-loop; other site 1111678003112 phosphorylation site [posttranslational modification] 1111678003113 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 1111678003114 putative transposase OrfB; Reviewed; Region: PHA02517 1111678003115 HTH-like domain; Region: HTH_21; pfam13276 1111678003116 Integrase core domain; Region: rve; pfam00665 1111678003117 Integrase core domain; Region: rve_3; pfam13683 1111678003118 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1111678003119 Transposase; Region: HTH_Tnp_1; pfam01527 1111678003120 Protein of unknown function (DUF805); Region: DUF805; pfam05656 1111678003121 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1111678003122 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1111678003123 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 1111678003124 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1111678003125 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 1111678003126 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1111678003127 metal-binding site [ion binding] 1111678003128 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1111678003129 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1111678003130 ligand binding site [chemical binding]; other site 1111678003131 flexible hinge region; other site 1111678003132 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1111678003133 putative switch regulator; other site 1111678003134 non-specific DNA interactions [nucleotide binding]; other site 1111678003135 DNA binding site [nucleotide binding] 1111678003136 sequence specific DNA binding site [nucleotide binding]; other site 1111678003137 putative cAMP binding site [chemical binding]; other site 1111678003138 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1111678003139 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 1111678003140 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1111678003141 putative active site [active] 1111678003142 catalytic site [active] 1111678003143 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 1111678003144 putative active site [active] 1111678003145 catalytic site [active] 1111678003146 Predicted P-loop-containing kinase [General function prediction only]; Region: COG1660 1111678003147 AAA domain; Region: AAA_18; pfam13238 1111678003148 Family of CofD-like proteins and proteins related to YvcK; Region: CofD_YvcK; cd07044 1111678003149 phosphate binding site [ion binding]; other site 1111678003150 dimer interface [polypeptide binding]; other site 1111678003151 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 1111678003152 WhiA N-terminal LAGLIDADG-like domain; Region: WhiA_N; pfam10298 1111678003153 WhiA LAGLIDADG-like domain; Region: LAGLIDADG_WhiA; pfam14527 1111678003154 WhiA C-terminal HTH domain; Region: HTH_WhiA; pfam02650 1111678003155 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1111678003156 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1111678003157 Walker A/P-loop; other site 1111678003158 ATP binding site [chemical binding]; other site 1111678003159 Q-loop/lid; other site 1111678003160 ABC transporter signature motif; other site 1111678003161 Walker B; other site 1111678003162 D-loop; other site 1111678003163 H-loop/switch region; other site 1111678003164 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 1111678003165 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 1111678003166 hypothetical protein; Provisional; Region: PRK13662 1111678003167 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 1111678003168 putative phosphoesterase; Region: acc_ester; TIGR03729 1111678003169 Similar to transposase for insertion sequence element IS982B; predicted non-functional due to frameshift 1111678003170 peptide chain release factor 2; Validated; Region: prfB; PRK00578 1111678003171 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1111678003172 RF-1 domain; Region: RF-1; pfam00472 1111678003173 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 1111678003174 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1111678003175 Walker A/P-loop; other site 1111678003176 ATP binding site [chemical binding]; other site 1111678003177 Q-loop/lid; other site 1111678003178 ABC transporter signature motif; other site 1111678003179 Walker B; other site 1111678003180 D-loop; other site 1111678003181 H-loop/switch region; other site 1111678003182 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 1111678003183 HD domain; Region: HD_3; cl17350 1111678003184 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 1111678003185 FtsX-like permease family; Region: FtsX; pfam02687 1111678003186 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 1111678003187 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1111678003188 dimer interface [polypeptide binding]; other site 1111678003189 putative radical transfer pathway; other site 1111678003190 diiron center [ion binding]; other site 1111678003191 tyrosyl radical; other site 1111678003192 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07306 1111678003193 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 1111678003194 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1111678003195 active site 1111678003196 dimer interface [polypeptide binding]; other site 1111678003197 catalytic residues [active] 1111678003198 effector binding site; other site 1111678003199 R2 peptide binding site; other site 1111678003200 Protein involved in ribonucleotide reduction [Nucleotide transport and metabolism]; Region: NrdI; COG1780 1111678003201 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1111678003202 catalytic residues [active] 1111678003203 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 1111678003204 DNA topoisomerase IV, B subunit, Gram-positive; Region: parE_Gpos; TIGR01058 1111678003205 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1111678003206 ATP binding site [chemical binding]; other site 1111678003207 Mg2+ binding site [ion binding]; other site 1111678003208 G-X-G motif; other site 1111678003209 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1111678003210 anchoring element; other site 1111678003211 dimer interface [polypeptide binding]; other site 1111678003212 ATP binding site [chemical binding]; other site 1111678003213 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 1111678003214 active site 1111678003215 metal binding site [ion binding]; metal-binding site 1111678003216 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1111678003217 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1111678003218 catalytic triad [active] 1111678003219 conserved cis-peptide bond; other site 1111678003220 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 1111678003221 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1111678003222 active site 1111678003223 catalytic site [active] 1111678003224 substrate binding site [chemical binding]; other site 1111678003225 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1111678003226 Coenzyme A binding pocket [chemical binding]; other site 1111678003227 DNA topoisomerase IV, A subunit, Gram-positive; Region: parC_Gpos; TIGR01061 1111678003228 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1111678003229 CAP-like domain; other site 1111678003230 active site 1111678003231 primary dimer interface [polypeptide binding]; other site 1111678003232 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1111678003233 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1111678003234 Similar to Magnesium and cobalt transport protein CorA; predicted non-functional due to transposon insertion 1111678003235 Similar to Tn946 Transposase; predictive non-functional due to frameshift 1111678003236 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 1111678003237 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 1111678003238 catalytic motif [active] 1111678003239 Zn binding site [ion binding]; other site 1111678003240 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 1111678003241 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 1111678003242 Lumazine binding domain; Region: Lum_binding; pfam00677 1111678003243 Lumazine binding domain; Region: Lum_binding; pfam00677 1111678003244 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 1111678003245 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 1111678003246 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1111678003247 dimerization interface [polypeptide binding]; other site 1111678003248 active site 1111678003249 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 1111678003250 homopentamer interface [polypeptide binding]; other site 1111678003251 active site 1111678003252 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1111678003253 Transposase; Region: HTH_Tnp_1; pfam01527 1111678003254 putative transposase OrfB; Reviewed; Region: PHA02517 1111678003255 HTH-like domain; Region: HTH_21; pfam13276 1111678003256 Integrase core domain; Region: rve; pfam00665 1111678003257 Integrase core domain; Region: rve_3; pfam13683 1111678003258 Predicted transcriptional regulator [Transcription]; Region: COG2378 1111678003259 HTH domain; Region: HTH_11; pfam08279 1111678003260 WYL domain; Region: WYL; pfam13280 1111678003261 lipoprotein signal peptidase; Provisional; Region: PRK14797 1111678003262 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1111678003263 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1111678003264 RNA binding surface [nucleotide binding]; other site 1111678003265 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1111678003266 active site 1111678003267 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 1111678003268 active site 1111678003269 Similar to hypothetical protein; predicted non-functional due to TAA stop codon 1111678003270 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1111678003271 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1111678003272 Ligand binding site; other site 1111678003273 Putative Catalytic site; other site 1111678003274 DXD motif; other site 1111678003275 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1111678003276 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1111678003277 active site 1111678003278 phosphorylation site [posttranslational modification] 1111678003279 intermolecular recognition site; other site 1111678003280 dimerization interface [polypeptide binding]; other site 1111678003281 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1111678003282 DNA binding site [nucleotide binding] 1111678003283 Predicted membrane protein (DUF2127); Region: DUF2127; cl01785 1111678003284 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1111678003285 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1111678003286 HAMP domain; Region: HAMP; pfam00672 1111678003287 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1111678003288 dimer interface [polypeptide binding]; other site 1111678003289 phosphorylation site [posttranslational modification] 1111678003290 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1111678003291 ATP binding site [chemical binding]; other site 1111678003292 Mg2+ binding site [ion binding]; other site 1111678003293 G-X-G motif; other site 1111678003294 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1111678003295 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1111678003296 active site 1111678003297 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1111678003298 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1111678003299 glutaminase active site [active] 1111678003300 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1111678003301 dimer interface [polypeptide binding]; other site 1111678003302 active site 1111678003303 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1111678003304 dimer interface [polypeptide binding]; other site 1111678003305 active site 1111678003306 Similar to DNA repair protein RadC; predicted non-functional due to frameshift 1111678003307 AT-rich DNA-binding protein [General function prediction only]; Region: COG2344 1111678003308 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 1111678003309 CoA binding domain; Region: CoA_binding; pfam02629 1111678003310 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 1111678003311 putative catalytic residues [active] 1111678003312 thiol/disulfide switch; other site 1111678003313 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1111678003314 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1111678003315 ABC transporter; Region: ABC_tran_2; pfam12848 1111678003316 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1111678003317 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1111678003318 active site 1111678003319 dihydroorotase; Validated; Region: pyrC; PRK09357 1111678003320 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1111678003321 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 1111678003322 active site 1111678003323 Transposase; Region: HTH_Tnp_1; cl17663 1111678003324 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1111678003325 Sel1-like repeats; Region: SEL1; smart00671 1111678003326 Sel1-like repeats; Region: SEL1; smart00671 1111678003327 Sel1 repeat; Region: Sel1; pfam08238 1111678003328 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1111678003329 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1111678003330 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 1111678003331 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 1111678003332 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 1111678003333 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 1111678003334 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 1111678003335 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 1111678003336 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 1111678003337 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 1111678003338 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 1111678003339 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 1111678003340 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 1111678003341 active site 1111678003342 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 1111678003343 DnaD and phage-associated domain; Region: DnaD_dom; TIGR01446 1111678003344 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 1111678003345 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1111678003346 minor groove reading motif; other site 1111678003347 helix-hairpin-helix signature motif; other site 1111678003348 substrate binding pocket [chemical binding]; other site 1111678003349 active site 1111678003350 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 1111678003351 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 1111678003352 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1111678003353 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4918 1111678003354 sugar phosphate phosphatase; Provisional; Region: PRK10513 1111678003355 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1111678003356 active site 1111678003357 motif I; other site 1111678003358 motif II; other site 1111678003359 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 1111678003360 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 1111678003361 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1111678003362 Zn2+ binding site [ion binding]; other site 1111678003363 Mg2+ binding site [ion binding]; other site 1111678003364 Domain of unknown function (DUF1934); Region: DUF1934; pfam09148 1111678003365 Protein of unknown function (DUF998); Region: DUF998; pfam06197 1111678003366 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 1111678003367 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1111678003368 Predicted ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG2868 1111678003369 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1111678003370 manganese transport protein MntH; Reviewed; Region: PRK00701 1111678003371 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1111678003372 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1111678003373 PhoH-like protein; Region: PhoH; pfam02562 1111678003374 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 1111678003375 nudix motif; other site 1111678003376 metal-binding heat shock protein; Provisional; Region: PRK00016 1111678003377 Integral membrane undecaprenol kinase and similar enzymes; Region: UDPK_IM_like; cd14265 1111678003378 trimer interface [polypeptide binding]; other site 1111678003379 putative active site [active] 1111678003380 Zn binding site [ion binding]; other site 1111678003381 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3575 1111678003382 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 1111678003383 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1111678003384 active site 1111678003385 Similar to ComF operon protein A, DNA transporter ATPase; predicted non-functional due to frameshift 1111678003386 Uncharacterized conserved protein [Function unknown]; Region: COG1739 1111678003387 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 1111678003388 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 1111678003389 VanZ like family; Region: VanZ; pfam04892 1111678003390 Similar to integral membrane protein; predicted non functional due to C to T conversion leading to TAA stop codon 1111678003391 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1111678003392 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1111678003393 active site 1111678003394 metal binding site [ion binding]; metal-binding site 1111678003395 T5orf172 domain; Region: T5orf172; pfam10544 1111678003396 glycyl-tRNA synthetase subunit alpha; Validated; Region: glyQ; PRK09348 1111678003397 motif 1; other site 1111678003398 dimer interface [polypeptide binding]; other site 1111678003399 active site 1111678003400 motif 2; other site 1111678003401 motif 3; other site 1111678003402 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 1111678003403 Glycyl-tRNA synthetase beta subunit; Region: tRNA_synt_2f; pfam02092 1111678003404 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1111678003405 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4224 1111678003406 ClC sycA-like chloride channel proteins. This ClC family presents in bacteria, where it facilitates acid resistance in acidic soil. Mutation of this gene (sycA) in Rhizobium tropici CIAT899 causes serious deficiencies in nodule development, nodulation...; Region: ClC_sycA_like; cd03682 1111678003407 putative Cl- selectivity filter; other site 1111678003408 putative pore gating glutamate residue; other site 1111678003409 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1111678003410 active site 1111678003411 (T/H)XGH motif; other site 1111678003412 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 1111678003413 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 1111678003414 active site 1111678003415 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1111678003416 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1111678003417 Coenzyme A binding pocket [chemical binding]; other site 1111678003418 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1111678003419 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 1111678003420 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1111678003421 homodimer interface [polypeptide binding]; other site 1111678003422 NAD binding pocket [chemical binding]; other site 1111678003423 ATP binding pocket [chemical binding]; other site 1111678003424 Mg binding site [ion binding]; other site 1111678003425 active-site loop [active] 1111678003426 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1111678003427 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1111678003428 Walker A/P-loop; other site 1111678003429 ATP binding site [chemical binding]; other site 1111678003430 Q-loop/lid; other site 1111678003431 ABC transporter signature motif; other site 1111678003432 Walker B; other site 1111678003433 D-loop; other site 1111678003434 H-loop/switch region; other site 1111678003435 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 1111678003436 FtsX-like permease family; Region: FtsX; pfam02687 1111678003437 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1111678003438 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1111678003439 FtsX-like permease family; Region: FtsX; pfam02687 1111678003440 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1111678003441 catalytic triad [active] 1111678003442 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 1111678003443 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1111678003444 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 1111678003445 Alpha-acetolactate decarboxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AlsD; COG3527 1111678003446 GTP-binding protein LepA; Provisional; Region: PRK05433 1111678003447 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1111678003448 G1 box; other site 1111678003449 putative GEF interaction site [polypeptide binding]; other site 1111678003450 GTP/Mg2+ binding site [chemical binding]; other site 1111678003451 Switch I region; other site 1111678003452 G2 box; other site 1111678003453 G3 box; other site 1111678003454 Switch II region; other site 1111678003455 G4 box; other site 1111678003456 G5 box; other site 1111678003457 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1111678003458 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1111678003459 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1111678003460 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1111678003461 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 1111678003462 NAD(P) binding site [chemical binding]; other site 1111678003463 putative active site [active] 1111678003464 inner membrane transporter YjeM; Provisional; Region: PRK15238 1111678003465 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1111678003466 Transposase; Region: HTH_Tnp_1; pfam01527 1111678003467 putative transposase OrfB; Reviewed; Region: PHA02517 1111678003468 HTH-like domain; Region: HTH_21; pfam13276 1111678003469 Integrase core domain; Region: rve; pfam00665 1111678003470 Integrase core domain; Region: rve_3; pfam13683 1111678003471 Similar to Type I restriction-modification system, specificity subunit S; predicted non-functional due to transposon insertion 1111678003472 HsdM N-terminal domain; Region: HsdM_N; pfam12161 1111678003473 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 1111678003474 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1111678003475 DNA gyrase subunit A; Validated; Region: PRK05560 1111678003476 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1111678003477 CAP-like domain; other site 1111678003478 active site 1111678003479 primary dimer interface [polypeptide binding]; other site 1111678003480 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1111678003481 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1111678003482 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1111678003483 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1111678003484 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1111678003485 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1111678003486 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 1111678003487 ApbE family; Region: ApbE; pfam02424 1111678003488 Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165 1111678003489 active site 1111678003490 catalytic site [active] 1111678003491 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1111678003492 Uncharacterized conserved protein [Function unknown]; Region: COG2898 1111678003493 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 1111678003494 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1111678003495 dimer interface [polypeptide binding]; other site 1111678003496 putative anticodon binding site; other site 1111678003497 Protein of unknown function (DUF998); Region: DUF998; pfam06197 1111678003498 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 1111678003499 Part of AAA domain; Region: AAA_19; pfam13245 1111678003500 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 1111678003501 Similar to ADP-ribose pyrophosphatase; predicted non-functional due to TAA stop codon 1111678003502 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 1111678003503 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1111678003504 dimer interface [polypeptide binding]; other site 1111678003505 fumarate reductase flavoprotein subunit; Validated; Region: PRK06481 1111678003506 L-aspartate oxidase; Provisional; Region: PRK06175 1111678003507 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1111678003508 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1111678003509 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1111678003510 Similar to cell surface protein precursor; predictive non-functional due to C to T conversion leading to TAA stop 1111678003511 Similar to hypothetical cell surface protein precursor; predicted non-functional due to TAA stop codon 1111678003512 Similar to hypothetical protein; predicted non-functional due to TAA stop codon 1111678003513 Similar to hypothetical protein; predicted non-functional due to TAA stop codon 1111678003514 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK02484 1111678003515 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1111678003516 RNA binding site [nucleotide binding]; other site 1111678003517 active site 1111678003518 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 1111678003519 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1111678003520 active site 1111678003521 Riboflavin kinase; Region: Flavokinase; smart00904 1111678003522 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 1111678003523 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 1111678003524 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1111678003525 NAD binding site [chemical binding]; other site 1111678003526 dimer interface [polypeptide binding]; other site 1111678003527 substrate binding site [chemical binding]; other site 1111678003528 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 1111678003529 N-acetylmuramic acid 6-phosphate etherase; Region: TIGR00274 1111678003530 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 1111678003531 putative active site [active] 1111678003532 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1111678003533 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 1111678003534 active site turn [active] 1111678003535 phosphorylation site [posttranslational modification] 1111678003536 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1111678003537 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1111678003538 HPr interaction site; other site 1111678003539 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1111678003540 active site 1111678003541 phosphorylation site [posttranslational modification] 1111678003542 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1111678003543 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1111678003544 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1111678003545 putative active site [active] 1111678003546 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1111678003547 substrate binding site [chemical binding]; other site 1111678003548 dimer interface [polypeptide binding]; other site 1111678003549 catalytic triad [active] 1111678003550 Similar to choloylglycine hydrolase; predicted non-functional due to TGA stop codon 1111678003551 Similar to phosphoadenosine phosphosulfate sulfotransferase; predicted non-functional due to frameshift 1111678003552 Similar to transcriptional regulator; predicted non-functional due to T to A conversion leading to TAG stop 1111678003553 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 1111678003554 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1111678003555 FeS/SAM binding site; other site 1111678003556 HemN C-terminal domain; Region: HemN_C; pfam06969 1111678003557 Lyzozyme M1 (1,4-beta-N-acetylmuramidase) [Cell envelope biogenesis, outer membrane]; Region: Acm; COG3757 1111678003558 PlyB is a bacteriophage endolysin that displays potent lytic activity toward Bacillus anthracis. PlyB has an N-terminal glycosyl hydrolase family 25 (GH25) catalytic domain and a C-terminal bacterial SH3-like domain, SH3b. Both domains are required for...; Region: GH25_PlyB-like; cd06523 1111678003559 active site 1111678003560 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 1111678003561 catalytic motif [active] 1111678003562 Zn binding site [ion binding]; other site 1111678003563 Acyl-ACP thioesterase [Lipid metabolism]; Region: FatA; COG3884 1111678003564 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1111678003565 active site 1111678003566 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1111678003567 active site 2 [active] 1111678003568 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 1111678003569 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1111678003570 active site 1111678003571 motif I; other site 1111678003572 motif II; other site 1111678003573 Predicted membrane protein [Function unknown]; Region: COG4478 1111678003574 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 1111678003575 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1111678003576 active site 1111678003577 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1111678003578 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1111678003579 active site 1111678003580 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 1111678003581 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1111678003582 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1111678003583 active site 1111678003584 Sulfate transporter family; Region: Sulfate_transp; cl19250 1111678003585 xanthine permease; Region: pbuX; TIGR03173 1111678003586 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 1111678003587 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1111678003588 folate binding site [chemical binding]; other site 1111678003589 NADP+ binding site [chemical binding]; other site 1111678003590 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1111678003591 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 1111678003592 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1111678003593 Walker A motif; other site 1111678003594 ATP binding site [chemical binding]; other site 1111678003595 Walker B motif; other site 1111678003596 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1111678003597 Predicted GTPase [General function prediction only]; Region: COG0218 1111678003598 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 1111678003599 G1 box; other site 1111678003600 GTP/Mg2+ binding site [chemical binding]; other site 1111678003601 Switch I region; other site 1111678003602 G2 box; other site 1111678003603 G3 box; other site 1111678003604 Switch II region; other site 1111678003605 G4 box; other site 1111678003606 G5 box; other site 1111678003607 Dihydroneopterin aldolase [Coenzyme metabolism]; Region: FolB; COG1539 1111678003608 active site 1111678003609 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1111678003610 catalytic center binding site [active] 1111678003611 ATP binding site [chemical binding]; other site 1111678003612 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 1111678003613 GTP cyclohydrolase I; Provisional; Region: PLN03044 1111678003614 active site 1111678003615 Dihydropteroate synthase and related enzymes [Coenzyme metabolism]; Region: FolP; COG0294 1111678003616 dihydropteroate synthase; Region: DHPS; TIGR01496 1111678003617 substrate binding pocket [chemical binding]; other site 1111678003618 dimer interface [polypeptide binding]; other site 1111678003619 inhibitor binding site; inhibition site 1111678003620 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1111678003621 nudix motif; other site 1111678003622 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 1111678003623 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1111678003624 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1111678003625 Similar to Deoxyadenosine kinase (EC 2.7.1.76); predicted none-functional due to G to T conversion leading to TAA stop 1111678003626 homoserine dehydrogenase; Provisional; Region: PRK06349 1111678003627 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1111678003628 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1111678003629 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1111678003630 homoserine kinase; Provisional; Region: PRK01212 1111678003631 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1111678003632 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1111678003633 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 1111678003634 FAD binding domain; Region: FAD_binding_4; pfam01565 1111678003635 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1111678003636 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1111678003637 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1111678003638 Walker A/P-loop; other site 1111678003639 ATP binding site [chemical binding]; other site 1111678003640 Q-loop/lid; other site 1111678003641 ABC transporter signature motif; other site 1111678003642 Walker B; other site 1111678003643 D-loop; other site 1111678003644 H-loop/switch region; other site 1111678003645 TOBE domain; Region: TOBE_2; pfam08402 1111678003646 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1111678003647 dimer interface [polypeptide binding]; other site 1111678003648 conserved gate region; other site 1111678003649 putative PBP binding loops; other site 1111678003650 ABC-ATPase subunit interface; other site 1111678003651 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1111678003652 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1111678003653 dimer interface [polypeptide binding]; other site 1111678003654 conserved gate region; other site 1111678003655 putative PBP binding loops; other site 1111678003656 ABC-ATPase subunit interface; other site 1111678003657 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 1111678003658 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1111678003659 Similar to MSM (multiple sugar metabolism) operon regulatory protein; predicted non-functional due to TAA stop codon 1111678003660 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1111678003661 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1111678003662 putative substrate translocation pore; other site 1111678003663 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 1111678003664 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 1111678003665 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 1111678003666 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 1111678003667 inhibitor binding site; inhibition site 1111678003668 active site 1111678003669 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1111678003670 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1111678003671 non-specific DNA binding site [nucleotide binding]; other site 1111678003672 salt bridge; other site 1111678003673 sequence-specific DNA binding site [nucleotide binding]; other site 1111678003674 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 1111678003675 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1111678003676 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1111678003677 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 1111678003678 putative catalytic residues [active] 1111678003679 thiol/disulfide switch; other site 1111678003680 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1111678003681 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 1111678003682 DNA binding residues [nucleotide binding] 1111678003683 putative dimer interface [polypeptide binding]; other site 1111678003684 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1111678003685 active site 1111678003686 catalytic tetrad [active] 1111678003687 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1111678003688 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1111678003689 putative transposase OrfB; Reviewed; Region: PHA02517 1111678003690 HTH-like domain; Region: HTH_21; pfam13276 1111678003691 Integrase core domain; Region: rve; pfam00665 1111678003692 Integrase core domain; Region: rve_3; pfam13683 1111678003693 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1111678003694 Transposase; Region: HTH_Tnp_1; pfam01527 1111678003695 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 1111678003696 putative active site cavity [active] 1111678003697 Similar to transcriptional regulator; predicted non-functional due to TAA stop codon 1111678003698 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 1111678003699 TRAM domain; Region: TRAM; cl01282 1111678003700 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1111678003701 S-adenosylmethionine binding site [chemical binding]; other site 1111678003702 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 1111678003703 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1111678003704 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1111678003705 S-adenosylmethionine binding site [chemical binding]; other site 1111678003706 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1111678003707 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 1111678003708 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1111678003709 binding surface 1111678003710 TPR motif; other site 1111678003711 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1111678003712 binding surface 1111678003713 TPR motif; other site 1111678003714 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1111678003715 binding surface 1111678003716 TPR motif; other site 1111678003717 acetolactate synthase; Reviewed; Region: PRK08617 1111678003718 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1111678003719 PYR/PP interface [polypeptide binding]; other site 1111678003720 dimer interface [polypeptide binding]; other site 1111678003721 TPP binding site [chemical binding]; other site 1111678003722 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1111678003723 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1111678003724 TPP-binding site [chemical binding]; other site 1111678003725 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1111678003726 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1111678003727 putative substrate translocation pore; other site 1111678003728 Predicted transcriptional regulators [Transcription]; Region: COG1733 1111678003729 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1111678003730 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1111678003731 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1111678003732 non-specific DNA binding site [nucleotide binding]; other site 1111678003733 salt bridge; other site 1111678003734 sequence-specific DNA binding site [nucleotide binding]; other site 1111678003735 Exoribonuclease R [Transcription]; Region: VacB; COG0557 1111678003736 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 1111678003737 RNB domain; Region: RNB; pfam00773 1111678003738 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 1111678003739 RNA binding site [nucleotide binding]; other site 1111678003740 TspO/MBR family; Region: TspO_MBR; pfam03073 1111678003741 Predicted membrane protein [Function unknown]; Region: COG4852 1111678003742 Predicted kinase related to dihydroxyacetone kinase [General function prediction only]; Region: COG1461 1111678003743 DAK2 domain; Region: Dak2; pfam02734 1111678003744 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1111678003745 Similar to hypothetical protein; predicted non-functional due to frameshift 1111678003746 histidinol-phosphate aminotransferase; Provisional; Region: PRK05387 1111678003747 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1111678003748 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1111678003749 homodimer interface [polypeptide binding]; other site 1111678003750 catalytic residue [active] 1111678003751 Histidyl-tRNA synthetase; Region: tRNA-synt_His; pfam13393 1111678003752 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1111678003753 dimer interface [polypeptide binding]; other site 1111678003754 motif 1; other site 1111678003755 active site 1111678003756 motif 2; other site 1111678003757 motif 3; other site 1111678003758 Similar to ATP phosphoribosyltransferase catalytic subunit (EC 2.4.2.17); predicted non-functional due to TGA stop codon 1111678003759 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1111678003760 histidinol dehydrogenase; Region: hisD; TIGR00069 1111678003761 NAD binding site [chemical binding]; other site 1111678003762 dimerization interface [polypeptide binding]; other site 1111678003763 product binding site; other site 1111678003764 substrate binding site [chemical binding]; other site 1111678003765 zinc binding site [ion binding]; other site 1111678003766 catalytic residues [active] 1111678003767 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 1111678003768 putative active site pocket [active] 1111678003769 4-fold oligomerization interface [polypeptide binding]; other site 1111678003770 metal binding residues [ion binding]; metal-binding site 1111678003771 3-fold/trimer interface [polypeptide binding]; other site 1111678003772 Phosphotransferase enzyme family; Region: APH; pfam01636 1111678003773 Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin...; Region: APH; cd05150 1111678003774 active site 1111678003775 ATP binding site [chemical binding]; other site 1111678003776 antibiotic binding site [chemical binding]; other site 1111678003777 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13142 1111678003778 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1111678003779 putative active site [active] 1111678003780 oxyanion strand; other site 1111678003781 catalytic triad [active] 1111678003782 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1111678003783 catalytic residues [active] 1111678003784 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1111678003785 substrate binding site [chemical binding]; other site 1111678003786 glutamase interaction surface [polypeptide binding]; other site 1111678003787 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 1111678003788 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 1111678003789 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 1111678003790 metal binding site [ion binding]; metal-binding site 1111678003791 histidinol phosphate phosphatase, HisJ family; Region: hisJ_fam; TIGR01856 1111678003792 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 1111678003793 active site 1111678003794 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 1111678003795 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 1111678003796 active site residue [active] 1111678003797 Protein of unknown function (DUF3650); Region: DUF3650; pfam12368 1111678003798 2-isopropylmalate synthase; Validated; Region: PRK00915 1111678003799 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 1111678003800 active site 1111678003801 catalytic residues [active] 1111678003802 metal binding site [ion binding]; metal-binding site 1111678003803 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 1111678003804 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 1111678003805 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1111678003806 Walker A motif; other site 1111678003807 ATP binding site [chemical binding]; other site 1111678003808 Walker B motif; other site 1111678003809 arginine finger; other site 1111678003810 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1111678003811 Integrase core domain; Region: rve; pfam00665 1111678003812 Similar to hypothetical protein; predicted non-functional due to transposon insertion 1111678003813 Protein of unknown function (DUF805); Region: DUF805; pfam05656 1111678003814 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 1111678003815 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1111678003816 nudix motif; other site 1111678003817 Similar to 3-isopropylmalate dehydratase large subunit; predicted non-functional due to frameshift 1111678003818 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1111678003819 substrate binding site [chemical binding]; other site 1111678003820 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1111678003821 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 1111678003822 Walker A/P-loop; other site 1111678003823 ATP binding site [chemical binding]; other site 1111678003824 Q-loop/lid; other site 1111678003825 ABC transporter signature motif; other site 1111678003826 Walker B; other site 1111678003827 D-loop; other site 1111678003828 H-loop/switch region; other site 1111678003829 Simialr to Dihydroxy-acid dehydratase (EC 4.2.1.9); predicted non-functional due to TTGTGGGGGC insertion leading to frameshift 1111678003830 Similar to Acetolactate synthase large subunit (EC 2.2.1.6); predicted non-functional due to TAA stop codon 1111678003831 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 1111678003832 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1111678003833 putative valine binding site [chemical binding]; other site 1111678003834 dimer interface [polypeptide binding]; other site 1111678003835 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 1111678003836 ketol-acid reductoisomerase; Provisional; Region: PRK05479 1111678003837 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 1111678003838 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1111678003839 threonine dehydratase; Validated; Region: PRK08639 1111678003840 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1111678003841 tetramer interface [polypeptide binding]; other site 1111678003842 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1111678003843 catalytic residue [active] 1111678003844 C-terminal regulatory domain of Threonine dehydratase; Region: Thr_dehydrat_C; pfam00585 1111678003845 alpha-acetolactate decarboxylase; Region: acetolac_decarb; TIGR01252 1111678003846 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1111678003847 homotrimer interaction site [polypeptide binding]; other site 1111678003848 putative active site [active] 1111678003849 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 1111678003850 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 1111678003851 DNA topoisomerase I; Validated; Region: PRK05582 1111678003852 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1111678003853 active site 1111678003854 interdomain interaction site; other site 1111678003855 putative metal-binding site [ion binding]; other site 1111678003856 nucleotide binding site [chemical binding]; other site 1111678003857 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1111678003858 domain I; other site 1111678003859 DNA binding groove [nucleotide binding] 1111678003860 phosphate binding site [ion binding]; other site 1111678003861 domain II; other site 1111678003862 domain III; other site 1111678003863 nucleotide binding site [chemical binding]; other site 1111678003864 catalytic site [active] 1111678003865 domain IV; other site 1111678003866 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1111678003867 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1111678003868 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 1111678003869 Glucose inhibited division protein A; Region: GIDA; pfam01134 1111678003870 site-specific tyrosine recombinase XerS; Reviewed; Region: xerS; PRK05084 1111678003871 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1111678003872 active site 1111678003873 DNA binding site [nucleotide binding] 1111678003874 Int/Topo IB signature motif; other site 1111678003875 Similar to NhaP-type Na+/H+ and K+/H+ antiporter; predicted non-functional due to truncation 1111678003876 hypothetical protein; Provisional; Region: PRK14013 1111678003877 Similar to transposase; predicted non-functional due to frameshift 1111678003878 putative transposase OrfB; Reviewed; Region: PHA02517 1111678003879 HTH-like domain; Region: HTH_21; pfam13276 1111678003880 Integrase core domain; Region: rve; pfam00665 1111678003881 Integrase core domain; Region: rve_3; pfam13683 1111678003882 Similar to hypothetical protein; predicted non-functional due to truncation 1111678003883 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 1111678003884 FAD binding site [chemical binding]; other site 1111678003885 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 1111678003886 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 1111678003887 THF binding site; other site 1111678003888 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1111678003889 substrate binding site [chemical binding]; other site 1111678003890 THF binding site; other site 1111678003891 zinc-binding site [ion binding]; other site 1111678003892 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 1111678003893 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1111678003894 Iron dependent repressor, metal binding and dimerization domain; Region: Fe_dep_repr_C; pfam02742 1111678003895 magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517 1111678003896 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 1111678003897 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1111678003898 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1111678003899 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 1111678003900 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1111678003901 Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltD; COG3966 1111678003902 DltD N-terminal region; Region: DltD_N; pfam04915 1111678003903 DltD central region; Region: DltD_M; pfam04918 1111678003904 DltD C-terminal region; Region: DltD_C; pfam04914 1111678003905 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 1111678003906 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 1111678003907 D-alanine--poly(phosphoribitol) ligase, subunit 1; Region: D-ala-DACP-lig; TIGR01734 1111678003908 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 1111678003909 acyl-activating enzyme (AAE) consensus motif; other site 1111678003910 AMP binding site [chemical binding]; other site 1111678003911 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1111678003912 thiamine phosphate binding site [chemical binding]; other site 1111678003913 active site 1111678003914 pyrophosphate binding site [ion binding]; other site 1111678003915 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1111678003916 dimer interface [polypeptide binding]; other site 1111678003917 substrate binding site [chemical binding]; other site 1111678003918 ATP binding site [chemical binding]; other site 1111678003919 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 1111678003920 substrate binding site [chemical binding]; other site 1111678003921 multimerization interface [polypeptide binding]; other site 1111678003922 ATP binding site [chemical binding]; other site 1111678003923 Similar to glycosyltransferase; predicted non-functional due to frameshift 1111678003924 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1111678003925 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1111678003926 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1111678003927 homodimer interface [polypeptide binding]; other site 1111678003928 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1111678003929 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1111678003930 putative substrate translocation pore; other site 1111678003931 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1111678003932 Transposase; Region: HTH_Tnp_1; pfam01527 1111678003933 putative transposase OrfB; Reviewed; Region: PHA02517 1111678003934 HTH-like domain; Region: HTH_21; pfam13276 1111678003935 Integrase core domain; Region: rve; pfam00665 1111678003936 Integrase core domain; Region: rve_3; pfam13683 1111678003937 Similar to transcriptional regulator, MarR family; predicted non-functional due to truncation 1111678003938 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1111678003939 core dimer interface [polypeptide binding]; other site 1111678003940 peripheral dimer interface [polypeptide binding]; other site 1111678003941 L10 interface [polypeptide binding]; other site 1111678003942 L11 interface [polypeptide binding]; other site 1111678003943 putative EF-Tu interaction site [polypeptide binding]; other site 1111678003944 putative EF-G interaction site [polypeptide binding]; other site 1111678003945 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1111678003946 23S rRNA interface [nucleotide binding]; other site 1111678003947 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1111678003948 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1111678003949 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1111678003950 non-specific DNA binding site [nucleotide binding]; other site 1111678003951 salt bridge; other site 1111678003952 sequence-specific DNA binding site [nucleotide binding]; other site 1111678003953 Predicted transcriptional regulator [Transcription]; Region: COG2932 1111678003954 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1111678003955 Catalytic site [active] 1111678003956 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1111678003957 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1111678003958 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1111678003959 Walker A/P-loop; other site 1111678003960 ATP binding site [chemical binding]; other site 1111678003961 Q-loop/lid; other site 1111678003962 ABC transporter signature motif; other site 1111678003963 Walker B; other site 1111678003964 D-loop; other site 1111678003965 H-loop/switch region; other site 1111678003966 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1111678003967 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 1111678003968 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1111678003969 Walker A/P-loop; other site 1111678003970 ATP binding site [chemical binding]; other site 1111678003971 Q-loop/lid; other site 1111678003972 ABC transporter signature motif; other site 1111678003973 Walker B; other site 1111678003974 D-loop; other site 1111678003975 H-loop/switch region; other site 1111678003976 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 1111678003977 Trypsin; Region: Trypsin; pfam00089 1111678003978 Predicted membrane protein [Function unknown]; Region: COG3601 1111678003979 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 1111678003980 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1111678003981 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1111678003982 RNA binding surface [nucleotide binding]; other site 1111678003983 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 1111678003984 active site 1111678003985 segregation and condensation protein B; Reviewed; Region: scpB; PRK00135 1111678003986 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 1111678003987 site-specific tyrosine recombinase XerD-like protein; Reviewed; Region: xerD; PRK02436 1111678003988 Phage integrase, N-terminal SAM-like domain; Region: Phage_int_SAM_4; pfam13495 1111678003989 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1111678003990 active site 1111678003991 catalytic residues [active] 1111678003992 DNA binding site [nucleotide binding] 1111678003993 Int/Topo IB signature motif; other site 1111678003994 FOG: CBS domain [General function prediction only]; Region: COG0517 1111678003995 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 1111678003996 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 1111678003997 active site 1111678003998 metal binding site [ion binding]; metal-binding site 1111678003999 homotetramer interface [polypeptide binding]; other site 1111678004000 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1111678004001 active site 1111678004002 dimerization interface [polypeptide binding]; other site 1111678004003 glutamate racemase; Provisional; Region: PRK00865 1111678004004 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3763 1111678004005 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 1111678004006 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1111678004007 active site 1111678004008 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1111678004009 substrate binding site [chemical binding]; other site 1111678004010 catalytic residues [active] 1111678004011 dimer interface [polypeptide binding]; other site 1111678004012 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 1111678004013 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster; Region: Fer4_20; pfam14691 1111678004014 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1111678004015 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1111678004016 NAD(P) binding site [chemical binding]; other site 1111678004017 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1111678004018 NAD binding site [chemical binding]; other site 1111678004019 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 1111678004020 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 1111678004021 active site 1111678004022 dimer interface [polypeptide binding]; other site 1111678004023 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 1111678004024 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1111678004025 active site 1111678004026 FMN binding site [chemical binding]; other site 1111678004027 substrate binding site [chemical binding]; other site 1111678004028 3Fe-4S cluster binding site [ion binding]; other site 1111678004029 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 1111678004030 domain interface; other site 1111678004031 maltose O-acetyltransferase; Provisional; Region: PRK10092 1111678004032 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 1111678004033 active site 1111678004034 substrate binding site [chemical binding]; other site 1111678004035 trimer interface [polypeptide binding]; other site 1111678004036 CoA binding site [chemical binding]; other site 1111678004037 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 1111678004038 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1111678004039 homodimer interface [polypeptide binding]; other site 1111678004040 substrate-cofactor binding pocket; other site 1111678004041 catalytic residue [active] 1111678004042 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1111678004043 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1111678004044 Similar to glutamate decarboxylase (EC 4.1.1.15); predicted non-functional due to frameshift 1111678004045 glutamate:gamma-aminobutyrate antiporter; Region: 2A0307_GadC; TIGR00910 1111678004046 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 1111678004047 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1111678004048 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1111678004049 Bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1111678004050 RNA/DNA hybrid binding site [nucleotide binding]; other site 1111678004051 active site 1111678004052 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 1111678004053 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 1111678004054 GTP/Mg2+ binding site [chemical binding]; other site 1111678004055 G4 box; other site 1111678004056 G5 box; other site 1111678004057 Guanylate-binding protein, N-terminal domain; Region: GBP; cl19296 1111678004058 G1 box; other site 1111678004059 Switch I region; other site 1111678004060 G2 box; other site 1111678004061 G3 box; other site 1111678004062 Switch II region; other site 1111678004063 Similar to GNAT family acetyltransferase; predicted non-functional due to truncation 1111678004064 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 1111678004065 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1111678004066 Walker A motif; other site 1111678004067 ATP binding site [chemical binding]; other site 1111678004068 Walker B motif; other site 1111678004069 arginine finger; other site 1111678004070 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1111678004071 Integrase core domain; Region: rve; pfam00665 1111678004072 Similar to hypothetical protein; predicted non-functional due to truncation 1111678004073 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1111678004074 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 1111678004075 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1111678004076 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1111678004077 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1111678004078 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 1111678004079 active site 1111678004080 Similar to Alpha-glucuronase, predicted non-functional due to C to T conversion leading to TAA stop 1111678004081 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1111678004082 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 1111678004083 NodB motif; other site 1111678004084 active site 1111678004085 catalytic site [active] 1111678004086 metal binding site [ion binding]; metal-binding site 1111678004087 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 1111678004088 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1111678004089 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1111678004090 dimer interface [polypeptide binding]; other site 1111678004091 conserved gate region; other site 1111678004092 putative PBP binding loops; other site 1111678004093 ABC-ATPase subunit interface; other site 1111678004094 Similar to alpha-xylose ABC transporter, permease component; predicted non-functional due to T to A conversion leading to TAA stop codon 1111678004095 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1111678004096 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1111678004097 Domain of unknown function (DUF303); Region: DUF303; pfam03629 1111678004098 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1111678004099 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1111678004100 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 1111678004101 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 1111678004102 metal binding site [ion binding]; metal-binding site 1111678004103 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1111678004104 ABC-ATPase subunit interface; other site 1111678004105 dimer interface [polypeptide binding]; other site 1111678004106 putative PBP binding regions; other site 1111678004107 Similar to manganese ABC transporter, ATP-binding protein SitB; predicted non-functional due to G to T conversion leading to TGA stop codon 1111678004108 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 1111678004109 Domain of unknown function (DUF4176); Region: DUF4176; cl01867 1111678004110 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 1111678004111 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 1111678004112 Walker A/P-loop; other site 1111678004113 ATP binding site [chemical binding]; other site 1111678004114 Q-loop/lid; other site 1111678004115 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 1111678004116 ABC transporter signature motif; other site 1111678004117 Walker B; other site 1111678004118 D-loop; other site 1111678004119 H-loop/switch region; other site 1111678004120 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 1111678004121 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1111678004122 active site 1111678004123 metal binding site [ion binding]; metal-binding site 1111678004124 DNA binding site [nucleotide binding] 1111678004125 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 1111678004126 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 1111678004127 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1111678004128 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1111678004129 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 1111678004130 putative catalytic residues [active] 1111678004131 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1111678004132 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1111678004133 Lactococcus lactis bacteriophage major structural protein; Region: L_lac_phage_MSP; pfam06488 1111678004134 Lactococcus lactis bacteriophage major structural protein; Region: L_lac_phage_MSP; pfam06488 1111678004135 Lactococcus lactis bacteriophage major structural protein; Region: L_lac_phage_MSP; pfam06488 1111678004136 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 1111678004137 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 1111678004138 Domain of unknown function (DUF814); Region: DUF814; pfam05670 1111678004139 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1111678004140 S-adenosylmethionine binding site [chemical binding]; other site 1111678004141 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 1111678004142 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1111678004143 Walker A/P-loop; other site 1111678004144 ATP binding site [chemical binding]; other site 1111678004145 Q-loop/lid; other site 1111678004146 ABC transporter signature motif; other site 1111678004147 Walker B; other site 1111678004148 D-loop; other site 1111678004149 H-loop/switch region; other site 1111678004150 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1111678004151 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1111678004152 TM-ABC transporter signature motif; other site 1111678004153 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1111678004154 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1111678004155 TM-ABC transporter signature motif; other site 1111678004156 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 1111678004157 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 1111678004158 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1111678004159 NAD binding site [chemical binding]; other site 1111678004160 dimer interface [polypeptide binding]; other site 1111678004161 substrate binding site [chemical binding]; other site 1111678004162 pyruvate kinase; Provisional; Region: PRK05826 1111678004163 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 1111678004164 domain interfaces; other site 1111678004165 active site 1111678004166 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 1111678004167 active site 1111678004168 ADP/pyrophosphate binding site [chemical binding]; other site 1111678004169 dimerization interface [polypeptide binding]; other site 1111678004170 allosteric effector site; other site 1111678004171 fructose-1,6-bisphosphate binding site; other site 1111678004172 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 1111678004173 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 1111678004174 active site 1111678004175 dimer interface [polypeptide binding]; other site 1111678004176 Uncharacterized protein involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TelA; COG3853 1111678004177 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 1111678004178 5-bromo-4-chloroindolyl phosphate hydrolysis protein; Region: Halogen_Hydrol; cl02059 1111678004179 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1111678004180 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1111678004181 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1111678004182 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1111678004183 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1111678004184 active site 1111678004185 tetramer interface; other site 1111678004186 Listerrria innocua Lin0431 is similar to the N-Utilization Substance G (NusG) N terminal (NGN) insert (DII); Region: Lin0431_like; cd09911 1111678004187 trimer interface [polypeptide binding]; other site 1111678004188 Predicted membrane protein [Function unknown]; Region: COG4769 1111678004189 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1111678004190 substrate binding pocket [chemical binding]; other site 1111678004191 chain length determination region; other site 1111678004192 substrate-Mg2+ binding site; other site 1111678004193 catalytic residues [active] 1111678004194 aspartate-rich region 1; other site 1111678004195 active site lid residues [active] 1111678004196 aspartate-rich region 2; other site 1111678004197 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 1111678004198 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1111678004199 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1111678004200 S-adenosylmethionine binding site [chemical binding]; other site 1111678004201 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1111678004202 active site 1111678004203 dimer interface [polypeptide binding]; other site 1111678004204 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 1111678004205 heterodimer interface [polypeptide binding]; other site 1111678004206 active site 1111678004207 FMN binding site [chemical binding]; other site 1111678004208 homodimer interface [polypeptide binding]; other site 1111678004209 substrate binding site [chemical binding]; other site 1111678004210 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 1111678004211 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 1111678004212 FAD binding pocket [chemical binding]; other site 1111678004213 FAD binding motif [chemical binding]; other site 1111678004214 phosphate binding motif [ion binding]; other site 1111678004215 beta-alpha-beta structure motif; other site 1111678004216 NAD binding pocket [chemical binding]; other site 1111678004217 Iron coordination center [ion binding]; other site 1111678004218 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1111678004219 putative substrate translocation pore; other site 1111678004220 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1111678004221 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1111678004222 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1111678004223 DNA-binding site [nucleotide binding]; DNA binding site 1111678004224 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1111678004225 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1111678004226 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 1111678004227 short chain dehydrogenase; Provisional; Region: PRK12937 1111678004228 classical (c) SDRs; Region: SDR_c; cd05233 1111678004229 NAD(P) binding site [chemical binding]; other site 1111678004230 active site 1111678004231 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1111678004232 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1111678004233 dimer interface [polypeptide binding]; other site 1111678004234 conserved gate region; other site 1111678004235 putative PBP binding loops; other site 1111678004236 ABC-ATPase subunit interface; other site 1111678004237 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1111678004238 dimer interface [polypeptide binding]; other site 1111678004239 conserved gate region; other site 1111678004240 putative PBP binding loops; other site 1111678004241 ABC-ATPase subunit interface; other site 1111678004242 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1111678004243 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1111678004244 Similar to hypothetical protein; predicted non-functional due to G to A conversion leading to TGA stop codon 1111678004245 Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448 1111678004246 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 1111678004247 Membrane protease subunit, stomatin/prohibitin family [Amino acid transport and metabolism]; Region: COG4260 1111678004248 Uncharacterized family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_like_u1; cd03408 1111678004249 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 1111678004250 Uncharacterized protein family UPF0547; Region: UPF0547; pfam10571 1111678004251 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 1111678004252 zinc-ribbons; Region: zinc-ribbons_6; pfam07191 1111678004253 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 1111678004254 Repair protein; Region: Repair_PSII; pfam04536 1111678004255 Pseudouridine synthase, Escherichia coli RluE; Region: PseudoU_synth_RluE; cd02566 1111678004256 pseudouridine synthase; Region: TIGR00093 1111678004257 probable active site [active] 1111678004258 glycerol kinase; Provisional; Region: glpK; PRK00047 1111678004259 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 1111678004260 N- and C-terminal domain interface [polypeptide binding]; other site 1111678004261 active site 1111678004262 MgATP binding site [chemical binding]; other site 1111678004263 catalytic site [active] 1111678004264 metal binding site [ion binding]; metal-binding site 1111678004265 glycerol binding site [chemical binding]; other site 1111678004266 homotetramer interface [polypeptide binding]; other site 1111678004267 homodimer interface [polypeptide binding]; other site 1111678004268 FBP binding site [chemical binding]; other site 1111678004269 protein IIAGlc interface [polypeptide binding]; other site 1111678004270 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 1111678004271 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 1111678004272 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 1111678004273 amphipathic channel; other site 1111678004274 Asn-Pro-Ala signature motifs; other site 1111678004275 WxL domain surface cell wall-binding; Region: WxL; pfam13731 1111678004276 putative transposase OrfB; Reviewed; Region: PHA02517 1111678004277 HTH-like domain; Region: HTH_21; pfam13276 1111678004278 Integrase core domain; Region: rve; pfam00665 1111678004279 Integrase core domain; Region: rve_3; pfam13683 1111678004280 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1111678004281 Transposase; Region: HTH_Tnp_1; pfam01527 1111678004282 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1111678004283 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1111678004284 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1111678004285 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; smart01096 1111678004286 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1111678004287 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1111678004288 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1111678004289 IMP binding site; other site 1111678004290 dimer interface [polypeptide binding]; other site 1111678004291 interdomain contacts; other site 1111678004292 partial ornithine binding site; other site 1111678004293 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1111678004294 catalytic residues [active] 1111678004295 dimer interface [polypeptide binding]; other site 1111678004296 Similar to N-acetylmuramoyl-L-alanine amase (EC 3.5.1.28); putative non-functional due to frameshift 1111678004297 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 1111678004298 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1111678004299 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1111678004300 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1111678004301 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1111678004302 motif II; other site 1111678004303 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1111678004304 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1636 1111678004305 Similar to hypothetical protein; predicted non-functional due to truncation 1111678004306 putative transposase OrfB; Reviewed; Region: PHA02517 1111678004307 HTH-like domain; Region: HTH_21; pfam13276 1111678004308 Integrase core domain; Region: rve; pfam00665 1111678004309 Integrase core domain; Region: rve_3; pfam13683 1111678004310 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 1111678004311 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1111678004312 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1111678004313 putative DNA-binding protein; Validated; Region: PRK00118 1111678004314 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1111678004315 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1111678004316 active site 1111678004317 phosphorylation site [posttranslational modification] 1111678004318 intermolecular recognition site; other site 1111678004319 dimerization interface [polypeptide binding]; other site 1111678004320 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1111678004321 DNA binding site [nucleotide binding] 1111678004322 Fungal protein of unknown function (DUF1774); Region: DUF1774; pfam08611 1111678004323 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1111678004324 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1111678004325 dimer interface [polypeptide binding]; other site 1111678004326 phosphorylation site [posttranslational modification] 1111678004327 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1111678004328 ATP binding site [chemical binding]; other site 1111678004329 Mg2+ binding site [ion binding]; other site 1111678004330 G-X-G motif; other site 1111678004331 Domain of unknown function (DUF4395); Region: DUF4395; pfam14340 1111678004332 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1111678004333 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1111678004334 DNA-binding site [nucleotide binding]; DNA binding site 1111678004335 UTRA domain; Region: UTRA; pfam07702 1111678004336 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 1111678004337 ligand binding site [chemical binding]; other site 1111678004338 Cytidine deaminase [Nucleotide transport and metabolism]; Region: Cdd; COG0295 1111678004339 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 1111678004340 active site 1111678004341 catalytic motif [active] 1111678004342 Zn binding site [ion binding]; other site 1111678004343 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 1111678004344 intersubunit interface [polypeptide binding]; other site 1111678004345 active site 1111678004346 catalytic residue [active] 1111678004347 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 1111678004348 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1111678004349 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1111678004350 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 1111678004351 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1111678004352 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1111678004353 S-adenosylmethionine binding site [chemical binding]; other site 1111678004354 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 1111678004355 ATP-binding site [chemical binding]; other site 1111678004356 CoA-binding site [chemical binding]; other site 1111678004357 Mg2+-binding site [ion binding]; other site 1111678004358 Phosphate-starvation-inducible E; Region: PsiE; cl01264 1111678004359 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1111678004360 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1111678004361 non-specific DNA binding site [nucleotide binding]; other site 1111678004362 salt bridge; other site 1111678004363 sequence-specific DNA binding site [nucleotide binding]; other site 1111678004364 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 1111678004365 ParB-like nuclease domain; Region: ParBc; pfam02195 1111678004366 Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969 1111678004367 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1111678004368 Active Sites [active] 1111678004369 Domain of unknown function (DUF3440); Region: DUF3440; pfam11922 1111678004370 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 1111678004371 Protein of unknown function (DUF3042); Region: DUF3042; pfam11240 1111678004372 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1111678004373 dimer interface [polypeptide binding]; other site 1111678004374 conserved gate region; other site 1111678004375 putative PBP binding loops; other site 1111678004376 ABC-ATPase subunit interface; other site 1111678004377 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 1111678004378 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1111678004379 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 1111678004380 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 1111678004381 Walker A/P-loop; other site 1111678004382 ATP binding site [chemical binding]; other site 1111678004383 Q-loop/lid; other site 1111678004384 ABC transporter signature motif; other site 1111678004385 Walker B; other site 1111678004386 D-loop; other site 1111678004387 H-loop/switch region; other site 1111678004388 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1111678004389 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1111678004390 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1111678004391 DNA-binding site [nucleotide binding]; DNA binding site 1111678004392 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 1111678004393 TrkA-C domain; Region: TrkA_C; pfam02080 1111678004394 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1111678004395 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 1111678004396 Similar to Tn946 Transposase; predicted non-functional due to frameshift 1111678004397 Similar to beta-glucose bgl operon antiterminator, BglG family; predicted non-functional due to transposon insertion 1111678004398 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1111678004399 substrate binding site [chemical binding]; other site 1111678004400 active site 1111678004401 catalytic residues [active] 1111678004402 heterodimer interface [polypeptide binding]; other site 1111678004403 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1111678004404 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1111678004405 catalytic residue [active] 1111678004406 Similar to Acetyltransferase (EC 2.3.1.-); predicted non-functional due to G to A conversion leading to TGA stop 1111678004407 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 1111678004408 active site 1111678004409 Uncharacterized nucleotidyltransferase; Region: NTP_transf_5; pfam14907 1111678004410 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1111678004411 active site 1111678004412 ribulose/triose binding site [chemical binding]; other site 1111678004413 phosphate binding site [ion binding]; other site 1111678004414 substrate (anthranilate) binding pocket [chemical binding]; other site 1111678004415 product (indole) binding pocket [chemical binding]; other site 1111678004416 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 1111678004417 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1111678004418 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1111678004419 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1111678004420 Glutamine amidotransferase class-I; Region: GATase; pfam00117 1111678004421 glutamine binding [chemical binding]; other site 1111678004422 catalytic triad [active] 1111678004423 anthranilate synthase component I; Provisional; Region: PRK13570 1111678004424 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1111678004425 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1111678004426 Similar to hypothetical protein; predicted non-functional due to TAA stop codon 1111678004427 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 1111678004428 dimer interface [polypeptide binding]; other site 1111678004429 FMN binding site [chemical binding]; other site 1111678004430 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1111678004431 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1111678004432 putative DNA binding site [nucleotide binding]; other site 1111678004433 putative Zn2+ binding site [ion binding]; other site 1111678004434 Methyltransferase domain; Region: Methyltransf_18; pfam12847 1111678004435 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 1111678004436 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 1111678004437 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1111678004438 metal binding site 2 [ion binding]; metal-binding site 1111678004439 putative DNA binding helix; other site 1111678004440 metal binding site 1 [ion binding]; metal-binding site 1111678004441 dimer interface [polypeptide binding]; other site 1111678004442 structural Zn2+ binding site [ion binding]; other site 1111678004443 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1111678004444 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1111678004445 Similar to transcriptional regulator, MerR family; predicted non-functional due to T to A conversion leading to TAA stop 1111678004446 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1111678004447 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1111678004448 NAD(P) binding site [chemical binding]; other site 1111678004449 active site 1111678004450 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK12315 1111678004451 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1111678004452 TPP-binding site; other site 1111678004453 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1111678004454 PYR/PP interface [polypeptide binding]; other site 1111678004455 dimer interface [polypeptide binding]; other site 1111678004456 TPP binding site [chemical binding]; other site 1111678004457 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1111678004458 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1111678004459 MarR family; Region: MarR; pfam01047 1111678004460 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 1111678004461 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 1111678004462 Cl binding site [ion binding]; other site 1111678004463 oligomer interface [polypeptide binding]; other site 1111678004464 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1111678004465 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 1111678004466 Glycosyl hydrolase family 67 N-terminus; Region: Glyco_hydro_67N; pfam03648 1111678004467 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1111678004468 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1111678004469 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1111678004470 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1111678004471 dimer interface [polypeptide binding]; other site 1111678004472 conserved gate region; other site 1111678004473 ABC-ATPase subunit interface; other site 1111678004474 2-aminoethylphosphonate transport system permease PhnU; Provisional; Region: PRK15050 1111678004475 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1111678004476 dimer interface [polypeptide binding]; other site 1111678004477 conserved gate region; other site 1111678004478 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1111678004479 ABC-ATPase subunit interface; other site 1111678004480 GMP synthase; Reviewed; Region: guaA; PRK00074 1111678004481 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1111678004482 AMP/PPi binding site [chemical binding]; other site 1111678004483 candidate oxyanion hole; other site 1111678004484 catalytic triad [active] 1111678004485 potential glutamine specificity residues [chemical binding]; other site 1111678004486 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1111678004487 ATP Binding subdomain [chemical binding]; other site 1111678004488 Ligand Binding sites [chemical binding]; other site 1111678004489 Dimerization subdomain; other site 1111678004490 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1111678004491 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1111678004492 nucleotide binding site [chemical binding]; other site 1111678004493 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1111678004494 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1111678004495 Similar to Xylanase; predicted non-functional due to C to A conversion leading to TAA stop codon 1111678004496 xylose isomerase; Provisional; Region: PRK05474 1111678004497 Cupin domain; Region: Cupin_2; cl17218 1111678004498 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1111678004499 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1111678004500 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 1111678004501 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1111678004502 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 1111678004503 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1111678004504 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1111678004505 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1111678004506 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 1111678004507 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1111678004508 tetracycline repressor protein TetR; Provisional; Region: PRK13756 1111678004509 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1111678004510 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1111678004511 Similar to inner membrane component of tripartite multrug resistance system; predicted non-functional due to C to T conversion leading to TAG stop 1111678004512 Similar to 2-haloalkanoic acid dehalogenase (EC 3.8.1.2); predicted non-functional due to C to T conversion leadnig to TGA stop 1111678004513 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1111678004514 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1111678004515 purine monophosphate binding site [chemical binding]; other site 1111678004516 dimer interface [polypeptide binding]; other site 1111678004517 putative catalytic residues [active] 1111678004518 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1111678004519 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1111678004520 active site 1111678004521 Similar to NADPH-dependent methylglyoxal reductase (D-lactaldehyde dehydrogenase); predicted non-functional due to frameshift 1111678004522 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1111678004523 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1111678004524 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1111678004525 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1111678004526 Walker A/P-loop; other site 1111678004527 ATP binding site [chemical binding]; other site 1111678004528 Q-loop/lid; other site 1111678004529 ABC transporter signature motif; other site 1111678004530 Walker B; other site 1111678004531 D-loop; other site 1111678004532 H-loop/switch region; other site 1111678004533 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1111678004534 active site 1111678004535 substrate binding site [chemical binding]; other site 1111678004536 cosubstrate binding site; other site 1111678004537 catalytic site [active] 1111678004538 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1111678004539 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1111678004540 dimerization interface [polypeptide binding]; other site 1111678004541 putative ATP binding site [chemical binding]; other site 1111678004542 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 1111678004543 Clp amino terminal domain; Region: Clp_N; pfam02861 1111678004544 Clp amino terminal domain; Region: Clp_N; pfam02861 1111678004545 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1111678004546 Walker A motif; other site 1111678004547 ATP binding site [chemical binding]; other site 1111678004548 Walker B motif; other site 1111678004549 arginine finger; other site 1111678004550 Centrosome localisation domain of PPC89; Region: Cep57_CLD_2; pfam14197 1111678004551 Protein of unknown function (DUF1090); Region: DUF1090; pfam06476 1111678004552 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1111678004553 Walker A motif; other site 1111678004554 ATP binding site [chemical binding]; other site 1111678004555 Walker B motif; other site 1111678004556 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1111678004557 Similar to hypothetical protein; predicted non-functional due to transposon insertion 1111678004558 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1111678004559 Integrase core domain; Region: rve; pfam00665 1111678004560 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1111678004561 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1111678004562 Walker A motif; other site 1111678004563 ATP binding site [chemical binding]; other site 1111678004564 Walker B motif; other site 1111678004565 arginine finger; other site 1111678004566 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1111678004567 NAD(P) binding site [chemical binding]; other site 1111678004568 active site 1111678004569 amidophosphoribosyltransferase; Provisional; Region: PRK07272 1111678004570 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1111678004571 active site 1111678004572 tetramer interface [polypeptide binding]; other site 1111678004573 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1111678004574 active site 1111678004575 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 1111678004576 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1111678004577 dimerization interface [polypeptide binding]; other site 1111678004578 ATP binding site [chemical binding]; other site 1111678004579 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 1111678004580 dimerization interface [polypeptide binding]; other site 1111678004581 ATP binding site [chemical binding]; other site 1111678004582 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 1111678004583 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1111678004584 putative active site [active] 1111678004585 catalytic triad [active] 1111678004586 Phosphoribosylformylglycinamidine (FGAM) synthase, PurS component [Nucleotide transport and metabolism]; Region: PurS; COG1828 1111678004587 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 1111678004588 ATP binding site [chemical binding]; other site 1111678004589 active site 1111678004590 substrate binding site [chemical binding]; other site 1111678004591 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1111678004592 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1111678004593 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1111678004594 Uncharacterized protein conserved in bacteria (DUF2255); Region: DUF2255; cl01788 1111678004595 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1111678004596 classical (c) SDRs; Region: SDR_c; cd05233 1111678004597 NAD(P) binding site [chemical binding]; other site 1111678004598 active site 1111678004599 putative transporter; Provisional; Region: PRK10504 1111678004600 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1111678004601 putative substrate translocation pore; other site 1111678004602 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1111678004603 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 1111678004604 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1111678004605 dimerization interface [polypeptide binding]; other site 1111678004606 active site 1111678004607 Similar to PTS system, cellobiose-specific IIC component (EC 2.7.1.69); putative non-functional due to truncation 1111678004608 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1111678004609 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1111678004610 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1111678004611 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 1111678004612 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 1111678004613 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1111678004614 substrate binding site [chemical binding]; other site 1111678004615 hexamer interface [polypeptide binding]; other site 1111678004616 metal binding site [ion binding]; metal-binding site 1111678004617 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1111678004618 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1111678004619 DNA binding site [nucleotide binding] 1111678004620 domain linker motif; other site 1111678004621 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1111678004622 ligand binding site [chemical binding]; other site 1111678004623 dimerization interface [polypeptide binding]; other site 1111678004624 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287 1111678004625 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1111678004626 catalytic Zn binding site [ion binding]; other site 1111678004627 NAD(P) binding site [chemical binding]; other site 1111678004628 structural Zn binding site [ion binding]; other site 1111678004629 Enterocin A Immunity; Region: EntA_Immun; pfam08951 1111678004630 Predicted membrane protein [Function unknown]; Region: COG4905 1111678004631 Dihydroorotate dehydrogenase (DHOD) class 1A FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1A_like; cd04741 1111678004632 active site 1111678004633 FMN binding site [chemical binding]; other site 1111678004634 substrate binding site [chemical binding]; other site 1111678004635 catalytic residues [active] 1111678004636 homodimer interface [polypeptide binding]; other site 1111678004637 Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225 1111678004638 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1111678004639 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1111678004640 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1111678004641 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1111678004642 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1111678004643 ABC transporter; Region: ABC_tran_2; pfam12848 1111678004644 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1111678004645 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1111678004646 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1111678004647 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1111678004648 dimerization interface [polypeptide binding]; other site 1111678004649 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 1111678004650 putative active site [active] 1111678004651 metal binding site [ion binding]; metal-binding site 1111678004652 Similar to hypothetical protein; predicted non-functional due to TGA stop codon 1111678004653 Dipeptidase [Amino acid transport and metabolism]; Region: PepD; COG4690 1111678004654 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 1111678004655 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1111678004656 active site 1111678004657 NTP binding site [chemical binding]; other site 1111678004658 metal binding triad [ion binding]; metal-binding site 1111678004659 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1111678004660 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 1111678004661 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1111678004662 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1111678004663 Coenzyme A binding pocket [chemical binding]; other site 1111678004664 dihydrodipicolinate reductase; Provisional; Region: PRK00048 1111678004665 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1111678004666 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1111678004667 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1111678004668 Protein of unknown function (DUF1149); Region: DUF1149; cl11551 1111678004669 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1111678004670 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1111678004671 RimM N-terminal domain; Region: RimM; pfam01782 1111678004672 PRC-barrel domain; Region: PRC; pfam05239 1111678004673 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1111678004674 Putative lysophospholipase; Region: Hydrolase_4; cl19140 1111678004675 Putative lysophospholipase; Region: Hydrolase_4; cl19140 1111678004676 Ferrochelatase; Region: Ferrochelatase; pfam00762 1111678004677 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 1111678004678 C-terminal domain interface [polypeptide binding]; other site 1111678004679 active site 1111678004680 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 1111678004681 active site 1111678004682 N-terminal domain interface [polypeptide binding]; other site 1111678004683 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 1111678004684 KH domain; Region: KH_4; pfam13083 1111678004685 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 1111678004686 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 1111678004687 homodimer interface [polypeptide binding]; other site 1111678004688 catalytic residues [active] 1111678004689 NAD binding site [chemical binding]; other site 1111678004690 substrate binding pocket [chemical binding]; other site 1111678004691 flexible flap; other site 1111678004692 putative acyltransferase; Provisional; Region: PRK05790 1111678004693 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1111678004694 dimer interface [polypeptide binding]; other site 1111678004695 active site 1111678004696 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 1111678004697 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 1111678004698 dimer interface [polypeptide binding]; other site 1111678004699 active site 1111678004700 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 1111678004701 active site 1111678004702 trimer interface [polypeptide binding]; other site 1111678004703 allosteric site; other site 1111678004704 active site lid [active] 1111678004705 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1111678004706 Putative lysophospholipase; Region: Hydrolase_4; cl19140 1111678004707 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1111678004708 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 1111678004709 Serine hydrolase (FSH1); Region: FSH1; pfam03959 1111678004710 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 1111678004711 GTPase CgtA; Reviewed; Region: obgE; PRK12297 1111678004712 GTP1/OBG; Region: GTP1_OBG; pfam01018 1111678004713 Obg GTPase; Region: Obg; cd01898 1111678004714 G1 box; other site 1111678004715 GTP/Mg2+ binding site [chemical binding]; other site 1111678004716 Switch I region; other site 1111678004717 G2 box; other site 1111678004718 G3 box; other site 1111678004719 Switch II region; other site 1111678004720 G4 box; other site 1111678004721 G5 box; other site 1111678004722 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 1111678004723 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 1111678004724 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1111678004725 Cell division protein FtsQ; Region: FtsQ; pfam03799 1111678004726 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 1111678004727 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1111678004728 homodimer interface [polypeptide binding]; other site 1111678004729 active site 1111678004730 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 1111678004731 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; cl19125 1111678004732 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1111678004733 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1111678004734 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 1111678004735 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 1111678004736 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1111678004737 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1111678004738 dimerization interface [polypeptide binding]; other site 1111678004739 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1111678004740 dimer interface [polypeptide binding]; other site 1111678004741 phosphorylation site [posttranslational modification] 1111678004742 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1111678004743 ATP binding site [chemical binding]; other site 1111678004744 Mg2+ binding site [ion binding]; other site 1111678004745 G-X-G motif; other site 1111678004746 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1111678004747 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1111678004748 active site 1111678004749 phosphorylation site [posttranslational modification] 1111678004750 intermolecular recognition site; other site 1111678004751 dimerization interface [polypeptide binding]; other site 1111678004752 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1111678004753 DNA binding site [nucleotide binding] 1111678004754 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 1111678004755 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 1111678004756 Similar to putative secreted protein; predicted non-functional due to truncation 1111678004757 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1111678004758 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 1111678004759 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1111678004760 catalytic site [active] 1111678004761 subunit interface [polypeptide binding]; other site 1111678004762 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 1111678004763 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1111678004764 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1111678004765 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 1111678004766 Sulfate transporter family; Region: Sulfate_transp; cl19250 1111678004767 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1111678004768 active site 1111678004769 Peptidase M50B-like; Region: Peptidase_M50B; pfam13398 1111678004770 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1111678004771 dimerization interface [polypeptide binding]; other site 1111678004772 putative DNA binding site [nucleotide binding]; other site 1111678004773 putative Zn2+ binding site [ion binding]; other site 1111678004774 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1111678004775 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 1111678004776 putative catalytic cysteine [active] 1111678004777 Glutamate 5-kinase [Amino acid transport and metabolism]; Region: ProB; COG0263 1111678004778 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1111678004779 nucleotide binding site [chemical binding]; other site 1111678004780 homotetrameric interface [polypeptide binding]; other site 1111678004781 putative phosphate binding site [ion binding]; other site 1111678004782 putative allosteric binding site; other site 1111678004783 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1111678004784 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1111678004785 Uncharacterized conserved protein [Function unknown]; Region: COG2461 1111678004786 Family of unknown function (DUF438); Region: DUF438; pfam04282 1111678004787 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 1111678004788 Domain of unknown function (DUF1858); Region: DUF1858; pfam08984 1111678004789 Predicted membrane protein [Function unknown]; Region: COG4392 1111678004790 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 1111678004791 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 1111678004792 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl19126 1111678004793 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl19126 1111678004794 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1111678004795 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1111678004796 Coenzyme A binding pocket [chemical binding]; other site 1111678004797 signal recognition particle protein; Provisional; Region: PRK10867 1111678004798 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1111678004799 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1111678004800 P loop; other site 1111678004801 GTP binding site [chemical binding]; other site 1111678004802 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1111678004803 Forkhead N-terminal region; Region: Fork_head_N; pfam08430 1111678004804 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1111678004805 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1111678004806 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 1111678004807 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1111678004808 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 1111678004809 RNA-metabolizing metallo-beta-lactamase; Region: RMMBL; pfam07521 1111678004810 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 1111678004811 MgtC family; Region: MgtC; pfam02308 1111678004812 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1111678004813 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1111678004814 dimer interface [polypeptide binding]; other site 1111678004815 active site 1111678004816 catalytic residue [active] 1111678004817 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1111678004818 nudix motif; other site 1111678004819 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 1111678004820 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118 1111678004821 Semialdehyde dehydrogenase, dimerization domain; Region: Semialdhyde_dhC; pfam02774 1111678004822 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 1111678004823 amphipathic channel; other site 1111678004824 Asn-Pro-Ala signature motifs; other site 1111678004825 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 1111678004826 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1111678004827 TPP-binding site [chemical binding]; other site 1111678004828 dimer interface [polypeptide binding]; other site 1111678004829 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1111678004830 PYR/PP interface [polypeptide binding]; other site 1111678004831 dimer interface [polypeptide binding]; other site 1111678004832 TPP binding site [chemical binding]; other site 1111678004833 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1111678004834 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 1111678004835 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 1111678004836 active site 1111678004837 P-loop; other site 1111678004838 phosphorylation site [posttranslational modification] 1111678004839 Similar to transcriptional antiterminator, BglG family; predicted non-functional due to TAG stop codon 1111678004840 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 1111678004841 active site 1111678004842 intersubunit interface [polypeptide binding]; other site 1111678004843 catalytic residue [active] 1111678004844 Similar to 2-dehydro-3-deoxygluconate kinase (EC 2.7.1.45) 1111678004845 glucuronate isomerase; Reviewed; Region: PRK02925 1111678004846 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 1111678004847 active site 1111678004848 catalytic residues [active] 1111678004849 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 1111678004850 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1111678004851 putative substrate translocation pore; other site 1111678004852 mannonate dehydratase; Provisional; Region: PRK03906 1111678004853 D-mannonate dehydratase (UxuA); Region: UxuA; pfam03786 1111678004854 Similar to D-mannonate oxoreductase; predicted non-functional due to TAG stop codon 1111678004855 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1111678004856 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1111678004857 DNA-binding site [nucleotide binding]; DNA binding site 1111678004858 FCD domain; Region: FCD; pfam07729 1111678004859 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1111678004860 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1111678004861 putative substrate translocation pore; other site 1111678004862 Enterocin A Immunity; Region: EntA_Immun; pfam08951 1111678004863 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1111678004864 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1111678004865 Similar to Tn946 transposase; predicted non-fuctional due to frameshift 1111678004866 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1111678004867 Integrase core domain; Region: rve; pfam00665 1111678004868 Similar to D-ribose pyranase; predicted non-functional due to transposon insertion 1111678004869 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1111678004870 substrate binding site [chemical binding]; other site 1111678004871 dimer interface [polypeptide binding]; other site 1111678004872 ATP binding site [chemical binding]; other site 1111678004873 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1111678004874 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1111678004875 DNA binding site [nucleotide binding] 1111678004876 domain linker motif; other site 1111678004877 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1111678004878 dimerization interface [polypeptide binding]; other site 1111678004879 ligand binding site [chemical binding]; other site 1111678004880 adenylosuccinate lyase; Provisional; Region: PRK07492 1111678004881 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 1111678004882 tetramer interface [polypeptide binding]; other site 1111678004883 active site 1111678004884 Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998 1111678004885 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 1111678004886 active site 1111678004887 catalytic residue [active] 1111678004888 dimer interface [polypeptide binding]; other site 1111678004889 Protein of unknown function (DUF2969); Region: DUF2969; pfam11184 1111678004890 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1111678004891 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1111678004892 catalytic residues [active] 1111678004893 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 1111678004894 MutS domain III; Region: MutS_III; pfam05192 1111678004895 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 1111678004896 Walker A/P-loop; other site 1111678004897 ATP binding site [chemical binding]; other site 1111678004898 Q-loop/lid; other site 1111678004899 ABC transporter signature motif; other site 1111678004900 Walker B; other site 1111678004901 D-loop; other site 1111678004902 H-loop/switch region; other site 1111678004903 Protein of unknown function (DUF972); Region: DUF972; pfam06156 1111678004904 Smr domain; Region: Smr; pfam01713 1111678004905 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 1111678004906 Colicin V production protein; Region: Colicin_V; pfam02674 1111678004907 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 1111678004908 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 1111678004909 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1111678004910 catabolite control protein A; Region: ccpA; TIGR01481 1111678004911 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1111678004912 DNA binding site [nucleotide binding] 1111678004913 domain linker motif; other site 1111678004914 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 1111678004915 dimerization interface [polypeptide binding]; other site 1111678004916 effector binding site; other site 1111678004917 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1111678004918 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1111678004919 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1111678004920 active site 1111678004921 Similar to hypothetical protein; predicted non-functional due to N-terminal truncation 1111678004922 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 1111678004923 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 1111678004924 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1111678004925 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 1111678004926 cell division protein GpsB; Provisional; Region: PRK14127; cl19517 1111678004927 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 1111678004928 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; cl19912 1111678004929 Similar to hypothetical protein; predicted non-functional due to TAG stop codon 1111678004930 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1111678004931 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 1111678004932 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1111678004933 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 1111678004934 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1111678004935 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1111678004936 active site 1111678004937 motif I; other site 1111678004938 motif II; other site 1111678004939 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 1111678004940 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 1111678004941 ATP-binding site [chemical binding]; other site 1111678004942 Sugar specificity; other site 1111678004943 Pyrimidine base specificity; other site 1111678004944 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1111678004945 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1111678004946 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1111678004947 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1111678004948 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1111678004949 Cpl-7 lysozyme C-terminal domain; Region: Cpl-7; smart01095 1111678004950 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 1111678004951 1,4-Dihydroxy-2-naphthoate octaprenyltransferase; Region: PT_UbiA_UBIAD1; cd13962 1111678004952 putative active site [active] 1111678004953 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 1111678004954 Cl- selectivity filter; other site 1111678004955 Cl- binding residues [ion binding]; other site 1111678004956 pore gating glutamate residue; other site 1111678004957 dimer interface [polypeptide binding]; other site 1111678004958 H+/Cl- coupling transport residue; other site 1111678004959 TrkA-C domain; Region: TrkA_C; pfam02080 1111678004960 Enterocin A Immunity; Region: EntA_Immun; pfam08951 1111678004961 Lactococcin-like family; Region: Lactococcin; pfam04369 1111678004962 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1111678004963 non-specific DNA binding site [nucleotide binding]; other site 1111678004964 salt bridge; other site 1111678004965 sequence-specific DNA binding site [nucleotide binding]; other site 1111678004966 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 1111678004967 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 1111678004968 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1111678004969 S-adenosylmethionine binding site [chemical binding]; other site 1111678004970 Predicted membrane protein [Function unknown]; Region: COG1511 1111678004971 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1111678004972 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 1111678004973 6-phospho-beta-glucosidase; Reviewed; Region: arb; PRK09593 1111678004974 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 1111678004975 Uncharacterized conserved protein [Function unknown]; Region: COG0759 1111678004976 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK12315 1111678004977 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1111678004978 TPP-binding site; other site 1111678004979 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1111678004980 PYR/PP interface [polypeptide binding]; other site 1111678004981 dimer interface [polypeptide binding]; other site 1111678004982 TPP binding site [chemical binding]; other site 1111678004983 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1111678004984 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1111678004985 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1111678004986 dimer interface [polypeptide binding]; other site 1111678004987 phosphorylation site [posttranslational modification] 1111678004988 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1111678004989 ATP binding site [chemical binding]; other site 1111678004990 Mg2+ binding site [ion binding]; other site 1111678004991 G-X-G motif; other site 1111678004992 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1111678004993 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1111678004994 active site 1111678004995 phosphorylation site [posttranslational modification] 1111678004996 intermolecular recognition site; other site 1111678004997 dimerization interface [polypeptide binding]; other site 1111678004998 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1111678004999 DNA binding site [nucleotide binding] 1111678005000 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1111678005001 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1111678005002 DNA binding site [nucleotide binding] 1111678005003 domain linker motif; other site 1111678005004 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 1111678005005 putative dimerization interface [polypeptide binding]; other site 1111678005006 putative ligand binding site [chemical binding]; other site 1111678005007 maltose phosphorylase; Provisional; Region: PRK13807 1111678005008 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 1111678005009 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 1111678005010 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 1111678005011 Similar to Alpha-glucosase (EC 3.2.1.20); predicted non-functional C to T conversion leading to TAA stop 1111678005012 Similar to alpha-amylase (EC 3.2.1.1); predicted non-functional due to A to T conversion leading to TAA stop codon; A to T conversion leading to TAA stop 1111678005013 maltose O-acetyltransferase; Provisional; Region: PRK10092 1111678005014 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 1111678005015 active site 1111678005016 substrate binding site [chemical binding]; other site 1111678005017 trimer interface [polypeptide binding]; other site 1111678005018 CoA binding site [chemical binding]; other site 1111678005019 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1111678005020 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1111678005021 Ca binding site [ion binding]; other site 1111678005022 active site 1111678005023 catalytic site [active] 1111678005024 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 1111678005025 homodimer interface [polypeptide binding]; other site 1111678005026 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 1111678005027 Alpha amylase, catalytic domain; Region: Alpha-amylase; pfam00128 1111678005028 active site 1111678005029 homodimer interface [polypeptide binding]; other site 1111678005030 catalytic site [active] 1111678005031 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 1111678005032 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1111678005033 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1111678005034 dimer interface [polypeptide binding]; other site 1111678005035 conserved gate region; other site 1111678005036 putative PBP binding loops; other site 1111678005037 ABC-ATPase subunit interface; other site 1111678005038 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1111678005039 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1111678005040 dimer interface [polypeptide binding]; other site 1111678005041 conserved gate region; other site 1111678005042 putative PBP binding loops; other site 1111678005043 ABC-ATPase subunit interface; other site 1111678005044 putative transposase OrfB; Reviewed; Region: PHA02517 1111678005045 HTH-like domain; Region: HTH_21; pfam13276 1111678005046 Integrase core domain; Region: rve; pfam00665 1111678005047 Integrase core domain; Region: rve_3; pfam13683 1111678005048 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1111678005049 Transposase; Region: HTH_Tnp_1; pfam01527 1111678005050 Similar to Tn982 Transposase; predicted non-functional due to truncation 1111678005051 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 1111678005052 catalytic triad [active] 1111678005053 dimer interface [polypeptide binding]; other site 1111678005054 conserved cis-peptide bond; other site 1111678005055 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1111678005056 cytidylate kinase; Provisional; Region: cmk; PRK00023 1111678005057 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1111678005058 CMP-binding site; other site 1111678005059 The sites determining sugar specificity; other site 1111678005060 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1111678005061 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 1111678005062 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 1111678005063 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 1111678005064 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1111678005065 active pocket/dimerization site; other site 1111678005066 active site 1111678005067 phosphorylation site [posttranslational modification] 1111678005068 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 1111678005069 active site 1111678005070 phosphorylation site [posttranslational modification] 1111678005071 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 1111678005072 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 1111678005073 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4687 1111678005074 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1111678005075 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1111678005076 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1111678005077 Domain of unknown function (DUF956); Region: DUF956; cl01917 1111678005078 seryl-tRNA synthetase; Provisional; Region: PRK05431 1111678005079 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1111678005080 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1111678005081 dimer interface [polypeptide binding]; other site 1111678005082 active site 1111678005083 motif 1; other site 1111678005084 motif 2; other site 1111678005085 motif 3; other site 1111678005086 Integrase core domain; Region: rve; pfam00665 1111678005087 DDE domain; Region: DDE_Tnp_IS240; pfam13610 1111678005088 Integrase core domain; Region: rve_3; pfam13683 1111678005089 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1111678005090 Transposase; Region: HTH_Tnp_1; pfam01527 1111678005091 Similar to Tn946 Transposase; predicted non-functional due to frameshift 1111678005092 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 1111678005093 putative dimer interface [polypeptide binding]; other site 1111678005094 catalytic triad [active] 1111678005095 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1111678005096 catalytic core [active] 1111678005097 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 1111678005098 PhoU domain; Region: PhoU; pfam01895 1111678005099 PhoU domain; Region: PhoU; pfam01895 1111678005100 phosphate transporter ATP-binding protein; Provisional; Region: PRK14239 1111678005101 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1111678005102 Walker A/P-loop; other site 1111678005103 ATP binding site [chemical binding]; other site 1111678005104 Q-loop/lid; other site 1111678005105 ABC transporter signature motif; other site 1111678005106 Walker B; other site 1111678005107 D-loop; other site 1111678005108 H-loop/switch region; other site 1111678005109 phosphate transporter ATP-binding protein; Provisional; Region: PRK14237 1111678005110 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1111678005111 Walker A/P-loop; other site 1111678005112 ATP binding site [chemical binding]; other site 1111678005113 Q-loop/lid; other site 1111678005114 ABC transporter signature motif; other site 1111678005115 Walker B; other site 1111678005116 D-loop; other site 1111678005117 H-loop/switch region; other site 1111678005118 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 1111678005119 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1111678005120 dimer interface [polypeptide binding]; other site 1111678005121 conserved gate region; other site 1111678005122 putative PBP binding loops; other site 1111678005123 ABC-ATPase subunit interface; other site 1111678005124 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 1111678005125 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1111678005126 dimer interface [polypeptide binding]; other site 1111678005127 conserved gate region; other site 1111678005128 putative PBP binding loops; other site 1111678005129 ABC-ATPase subunit interface; other site 1111678005130 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 1111678005131 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 1111678005132 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1111678005133 SmpB-tmRNA interface; other site 1111678005134 Predicted transcriptional regulators [Transcription]; Region: COG1733 1111678005135 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1111678005136 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 1111678005137 dimer interface [polypeptide binding]; other site 1111678005138 FMN binding site [chemical binding]; other site 1111678005139 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1111678005140 active site 1111678005141 catalytic triad [active] 1111678005142 oxyanion hole [active] 1111678005143 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1111678005144 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1111678005145 motif 1; other site 1111678005146 active site 1111678005147 motif 2; other site 1111678005148 motif 3; other site 1111678005149 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1111678005150 DHHA1 domain; Region: DHHA1; pfam02272 1111678005151 foldase protein PrsA; Reviewed; Region: PRK12450 1111678005152 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 1111678005153 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1111678005154 S-adenosylmethionine binding site [chemical binding]; other site 1111678005155 Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164 1111678005156 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 1111678005157 active site 1111678005158 Zn binding site [ion binding]; other site 1111678005159 Competence protein CoiA-like family; Region: CoiA; pfam06054 1111678005160 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 1111678005161 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1111678005162 putative active site [active] 1111678005163 Similar to hypothetical protein; predicted non-functional due to frameshift 1111678005164 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1111678005165 Sulfate transporter family; Region: Sulfate_transp; cl19250 1111678005166 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1111678005167 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1111678005168 active site 1111678005169 motif I; other site 1111678005170 motif II; other site 1111678005171 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 1111678005172 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1111678005173 Cysteine-rich domain; Region: CCG; pfam02754 1111678005174 Cysteine-rich domain; Region: CCG; pfam02754 1111678005175 Similar to Fe-S cluster-binding protein; predicted non-functional due to C to T conversion leading to TGA stop 1111678005176 Uncharacterized conserved protein [Function unknown]; Region: COG1556 1111678005177 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 1111678005178 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 1111678005179 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1111678005180 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 1111678005181 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1111678005182 Zn2+ binding site [ion binding]; other site 1111678005183 Mg2+ binding site [ion binding]; other site 1111678005184 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1111678005185 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 1111678005186 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 1111678005187 Helix-hairpin-helix containing domain; Region: HHH_4; pfam14490 1111678005188 AAA domain; Region: AAA_30; pfam13604 1111678005189 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 1111678005190 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1111678005191 catalytic core [active] 1111678005192 prephenate dehydratase; Provisional; Region: PRK11898 1111678005193 Prephenate dehydratase; Region: PDT; pfam00800 1111678005194 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1111678005195 putative L-Phe binding site [chemical binding]; other site 1111678005196 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 1111678005197 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1111678005198 ADP binding site [chemical binding]; other site 1111678005199 magnesium binding site [ion binding]; other site 1111678005200 putative shikimate binding site; other site 1111678005201 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 1111678005202 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1111678005203 hinge; other site 1111678005204 active site 1111678005205 prephenate dehydrogenase; Validated; Region: PRK06545 1111678005206 prephenate dehydrogenase; Validated; Region: PRK08507 1111678005207 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1111678005208 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1111678005209 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1111678005210 ATP binding site [chemical binding]; other site 1111678005211 Mg2+ binding site [ion binding]; other site 1111678005212 G-X-G motif; other site 1111678005213 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1111678005214 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1111678005215 active site 1111678005216 phosphorylation site [posttranslational modification] 1111678005217 intermolecular recognition site; other site 1111678005218 dimerization interface [polypeptide binding]; other site 1111678005219 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1111678005220 DNA binding site [nucleotide binding] 1111678005221 Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767 1111678005222 FtsX-like permease family; Region: FtsX; pfam02687 1111678005223 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1111678005224 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1111678005225 Walker A/P-loop; other site 1111678005226 ATP binding site [chemical binding]; other site 1111678005227 Q-loop/lid; other site 1111678005228 ABC transporter signature motif; other site 1111678005229 Walker B; other site 1111678005230 D-loop; other site 1111678005231 H-loop/switch region; other site 1111678005232 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5294 1111678005233 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1111678005234 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 1111678005235 Tetramer interface [polypeptide binding]; other site 1111678005236 active site 1111678005237 FMN-binding site [chemical binding]; other site 1111678005238 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 1111678005239 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1111678005240 motif II; other site 1111678005241 Protein of unknown function (DUF1054); Region: DUF1054; cl19868 1111678005242 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 1111678005243 Protein of unknown function, DUF606; Region: DUF606; pfam04657 1111678005244 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1111678005245 active site 1111678005246 dimer interface [polypeptide binding]; other site 1111678005247 metal binding site [ion binding]; metal-binding site 1111678005248 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 1111678005249 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1111678005250 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1111678005251 shikimate binding site; other site 1111678005252 NAD(P) binding site [chemical binding]; other site 1111678005253 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1111678005254 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1111678005255 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1111678005256 substrate binding pocket [chemical binding]; other site 1111678005257 membrane-bound complex binding site; other site 1111678005258 hinge residues; other site 1111678005259 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1111678005260 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1111678005261 substrate binding pocket [chemical binding]; other site 1111678005262 membrane-bound complex binding site; other site 1111678005263 hinge residues; other site 1111678005264 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 1111678005265 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1111678005266 dimer interface [polypeptide binding]; other site 1111678005267 conserved gate region; other site 1111678005268 putative PBP binding loops; other site 1111678005269 ABC-ATPase subunit interface; other site 1111678005270 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1111678005271 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1111678005272 Walker A/P-loop; other site 1111678005273 ATP binding site [chemical binding]; other site 1111678005274 Q-loop/lid; other site 1111678005275 ABC transporter signature motif; other site 1111678005276 Walker B; other site 1111678005277 D-loop; other site 1111678005278 H-loop/switch region; other site 1111678005279 Similar to hypothetical protein; predicted non-functional due to frameshift 1111678005280 putative transposase OrfB; Reviewed; Region: PHA02517 1111678005281 HTH-like domain; Region: HTH_21; pfam13276 1111678005282 Integrase core domain; Region: rve; pfam00665 1111678005283 Integrase core domain; Region: rve_3; pfam13683 1111678005284 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1111678005285 Transposase; Region: HTH_Tnp_1; pfam01527 1111678005286 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 1111678005287 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1111678005288 gamma subunit interface [polypeptide binding]; other site 1111678005289 epsilon subunit interface [polypeptide binding]; other site 1111678005290 LBP interface [polypeptide binding]; other site 1111678005291 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1111678005292 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1111678005293 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1111678005294 alpha subunit interaction interface [polypeptide binding]; other site 1111678005295 Walker A motif; other site 1111678005296 ATP binding site [chemical binding]; other site 1111678005297 Walker B motif; other site 1111678005298 inhibitor binding site; inhibition site 1111678005299 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1111678005300 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1111678005301 core domain interface [polypeptide binding]; other site 1111678005302 delta subunit interface [polypeptide binding]; other site 1111678005303 epsilon subunit interface [polypeptide binding]; other site 1111678005304 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1111678005305 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1111678005306 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1111678005307 beta subunit interaction interface [polypeptide binding]; other site 1111678005308 Walker A motif; other site 1111678005309 ATP binding site [chemical binding]; other site 1111678005310 Walker B motif; other site 1111678005311 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1111678005312 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 1111678005313 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 1111678005314 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 1111678005315 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 1111678005316 F0F1 ATP synthase subunit C; Provisional; Region: PRK13466 1111678005317 Predicted esterase [General function prediction only]; Region: COG0627 1111678005318 S-formylglutathione hydrolase; Region: PLN02442 1111678005319 Similar to late competence protein ComEC; predicted non-functional due to truncation 1111678005320 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1111678005321 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1111678005322 Similar to Late competence protein ComEC, DNA transport; predicted non-fucntional due to frameshift 1111678005323 SLBB domain; Region: SLBB; pfam10531 1111678005324 comEA protein; Region: comE; TIGR01259 1111678005325 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 1111678005326 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 1111678005327 Acyltransferase family; Region: Acyl_transf_3; cl19154 1111678005328 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 1111678005329 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1111678005330 Walker A/P-loop; other site 1111678005331 ATP binding site [chemical binding]; other site 1111678005332 Q-loop/lid; other site 1111678005333 ABC transporter signature motif; other site 1111678005334 Walker B; other site 1111678005335 D-loop; other site 1111678005336 H-loop/switch region; other site 1111678005337 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 1111678005338 Similar to Phosphinothricin N-acetyltransferase; predicted non-functional due to frameshift 1111678005339 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1111678005340 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1111678005341 transmembrane helices; other site 1111678005342 Putative transcription activator [Transcription]; Region: TenA; COG0819 1111678005343 Zinc finger domain containing protein (CHY type) [Function unknown]; Region: COG4357 1111678005344 CHY zinc finger; Region: zf-CHY; pfam05495 1111678005345 Biotin operon repressor [Transcription]; Region: BirA; COG1654 1111678005346 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 1111678005347 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 1111678005348 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 1111678005349 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 1111678005350 putative transposase OrfB; Reviewed; Region: PHA02517 1111678005351 HTH-like domain; Region: HTH_21; pfam13276 1111678005352 Integrase core domain; Region: rve; pfam00665 1111678005353 Integrase core domain; Region: rve_3; pfam13683 1111678005354 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1111678005355 Transposase; Region: HTH_Tnp_1; pfam01527 1111678005356 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 1111678005357 FeS assembly protein SufB; Region: sufB; TIGR01980 1111678005358 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 1111678005359 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1111678005360 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1111678005361 trimerization site [polypeptide binding]; other site 1111678005362 active site 1111678005363 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1111678005364 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1111678005365 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1111678005366 catalytic residue [active] 1111678005367 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 1111678005368 FeS assembly protein SufD; Region: sufD; TIGR01981 1111678005369 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 1111678005370 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 1111678005371 Walker A/P-loop; other site 1111678005372 ATP binding site [chemical binding]; other site 1111678005373 Q-loop/lid; other site 1111678005374 ABC transporter signature motif; other site 1111678005375 Walker B; other site 1111678005376 D-loop; other site 1111678005377 H-loop/switch region; other site 1111678005378 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 1111678005379 Mg++ binding site [ion binding]; other site 1111678005380 putative catalytic motif [active] 1111678005381 substrate binding site [chemical binding]; other site 1111678005382 Negative regulator of genetic competence, sporulation and motility [Posttranslational modification, protein turnover, chaperones / Signal transduction mechanisms / Cell motility and secretion]; Region: MecA; COG4862 1111678005383 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1111678005384 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1111678005385 Walker A/P-loop; other site 1111678005386 ATP binding site [chemical binding]; other site 1111678005387 Q-loop/lid; other site 1111678005388 ABC transporter signature motif; other site 1111678005389 Walker B; other site 1111678005390 D-loop; other site 1111678005391 H-loop/switch region; other site 1111678005392 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 1111678005393 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1111678005394 dimer interface [polypeptide binding]; other site 1111678005395 conserved gate region; other site 1111678005396 putative PBP binding loops; other site 1111678005397 ABC-ATPase subunit interface; other site 1111678005398 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 1111678005399 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1111678005400 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 1111678005401 Largest subunit (beta') of bacterial DNA-dependent RNA polymerase (RNAP), N-terminal domain; Region: RNAP_beta'_N; cd01609 1111678005402 beta and beta' interface [polypeptide binding]; other site 1111678005403 beta' and sigma factor interface [polypeptide binding]; other site 1111678005404 Zn-binding [ion binding]; other site 1111678005405 active site region [active] 1111678005406 catalytic site [active] 1111678005407 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 1111678005408 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1111678005409 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 1111678005410 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1111678005411 G-loop; other site 1111678005412 DNA binding site [nucleotide binding] 1111678005413 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1111678005414 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1111678005415 RPB12 interaction site [polypeptide binding]; other site 1111678005416 RNA polymerase beta subunit; Region: RNA_pol_Rpb2_1; cl19478 1111678005417 RPB1 interaction site [polypeptide binding]; other site 1111678005418 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 1111678005419 RPB10 interaction site [polypeptide binding]; other site 1111678005420 RPB11 interaction site [polypeptide binding]; other site 1111678005421 RPB3 interaction site [polypeptide binding]; other site 1111678005422 CodY GAF-like domain; Region: CodY; pfam06018 1111678005423 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1111678005424 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1111678005425 non-specific DNA binding site [nucleotide binding]; other site 1111678005426 salt bridge; other site 1111678005427 sequence-specific DNA binding site [nucleotide binding]; other site 1111678005428 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 1111678005429 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 1111678005430 active site 1111678005431 Zn binding site [ion binding]; other site 1111678005432 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1111678005433 active site 1111678005434 DNA binding site [nucleotide binding] 1111678005435 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1111678005436 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 1111678005437 UDP-N-acetylmuramoylalanyl-D-glutamate--L-lysine ligase; Provisional; Region: PRK14022 1111678005438 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1111678005439 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1111678005440 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1111678005441 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 1111678005442 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 1111678005443 NAD binding site [chemical binding]; other site 1111678005444 substrate binding site [chemical binding]; other site 1111678005445 catalytic Zn binding site [ion binding]; other site 1111678005446 tetramer interface [polypeptide binding]; other site 1111678005447 structural Zn binding site [ion binding]; other site 1111678005448 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 1111678005449 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1111678005450 ATP binding site [chemical binding]; other site 1111678005451 putative Mg++ binding site [ion binding]; other site 1111678005452 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1111678005453 nucleotide binding region [chemical binding]; other site 1111678005454 ATP-binding site [chemical binding]; other site 1111678005455 RQC domain; Region: RQC; pfam09382 1111678005456 HRDC domain; Region: HRDC; pfam00570 1111678005457 Similar to putative amino acid permease; predicted non-functional due to truncation 1111678005458 peptidase T-like protein; Region: PepT-like; TIGR01883 1111678005459 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 1111678005460 metal binding site [ion binding]; metal-binding site 1111678005461 dimer interface [polypeptide binding]; other site 1111678005462 Domain of unknown function (DUF1803); Region: DUF1803; pfam08820 1111678005463 Domain of unknown function (DUF1803); Region: DUF1803; pfam08820 1111678005464 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 1111678005465 DHH family; Region: DHH; pfam01368 1111678005466 DHHA2 domain; Region: DHHA2; pfam02833 1111678005467 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 1111678005468 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1111678005469 FeS/SAM binding site; other site 1111678005470 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1111678005471 Domain of unknown function DUF21; Region: DUF21; pfam01595 1111678005472 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1111678005473 Transporter associated domain; Region: CorC_HlyC; smart01091 1111678005474 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1111678005475 Predicted transcriptional regulator [Transcription]; Region: COG1959 1111678005476 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1111678005477 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1111678005478 NAD(P) binding site [chemical binding]; other site 1111678005479 active site 1111678005480 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1111678005481 Coenzyme A binding pocket [chemical binding]; other site 1111678005482 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1111678005483 Bacteriophage peptidoglycan hydrolase; Region: Amidase_5; pfam05382 1111678005484 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1111678005485 Similar to hypothetical protein; predicted non-functional due to TAA stop codon 1111678005486 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033 1111678005487 putative uracil binding site [chemical binding]; other site 1111678005488 putative active site [active] 1111678005489 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1111678005490 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1111678005491 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1111678005492 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1111678005493 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 1111678005494 GIY-YIG motif/motif A; other site 1111678005495 putative active site [active] 1111678005496 putative metal binding site [ion binding]; other site 1111678005497 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1111678005498 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1111678005499 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1111678005500 Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564 1111678005501 Thiamine pyrophosphokinase; Region: TPK; cd07995 1111678005502 active site 1111678005503 dimerization interface [polypeptide binding]; other site 1111678005504 thiamine binding site [chemical binding]; other site 1111678005505 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u4; cd11541 1111678005506 putative metal binding site [ion binding]; other site 1111678005507 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 1111678005508 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 1111678005509 putative dimer interface [polypeptide binding]; other site 1111678005510 putative anticodon binding site; other site 1111678005511 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 1111678005512 homodimer interface [polypeptide binding]; other site 1111678005513 motif 1; other site 1111678005514 motif 2; other site 1111678005515 active site 1111678005516 motif 3; other site 1111678005517 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 1111678005518 GIY-YIG motif/motif A; other site 1111678005519 active site 1111678005520 catalytic site [active] 1111678005521 metal binding site [ion binding]; metal-binding site 1111678005522 aspartate aminotransferase; Provisional; Region: PRK05764 1111678005523 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1111678005524 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1111678005525 homodimer interface [polypeptide binding]; other site 1111678005526 catalytic residue [active] 1111678005527 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 1111678005528 DnaQ family exonuclease/DinG family helicase, putative; Region: dinG_rel; TIGR01407 1111678005529 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1111678005530 active site 1111678005531 catalytic site [active] 1111678005532 substrate binding site [chemical binding]; other site 1111678005533 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1111678005534 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1111678005535 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1111678005536 Ligand Binding Site [chemical binding]; other site 1111678005537 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1111678005538 The substrate binding component of an ABC-type lactococcal OppA-like transport system contains; Region: PBP2_Lactococcal_OppA_like; cd08510 1111678005539 peptide binding site [polypeptide binding]; other site 1111678005540 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1111678005541 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1111678005542 dimer interface [polypeptide binding]; other site 1111678005543 conserved gate region; other site 1111678005544 putative PBP binding loops; other site 1111678005545 ABC-ATPase subunit interface; other site 1111678005546 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1111678005547 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1111678005548 dimer interface [polypeptide binding]; other site 1111678005549 conserved gate region; other site 1111678005550 putative PBP binding loops; other site 1111678005551 ABC-ATPase subunit interface; other site 1111678005552 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1111678005553 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1111678005554 Walker A/P-loop; other site 1111678005555 ATP binding site [chemical binding]; other site 1111678005556 Q-loop/lid; other site 1111678005557 ABC transporter signature motif; other site 1111678005558 Walker B; other site 1111678005559 D-loop; other site 1111678005560 H-loop/switch region; other site 1111678005561 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1111678005562 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1111678005563 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1111678005564 Walker A/P-loop; other site 1111678005565 ATP binding site [chemical binding]; other site 1111678005566 Q-loop/lid; other site 1111678005567 ABC transporter signature motif; other site 1111678005568 Walker B; other site 1111678005569 D-loop; other site 1111678005570 H-loop/switch region; other site 1111678005571 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1111678005572 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1111678005573 23S rRNA binding site [nucleotide binding]; other site 1111678005574 L21 binding site [polypeptide binding]; other site 1111678005575 L13 binding site [polypeptide binding]; other site 1111678005576 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1111678005577 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 1111678005578 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1111678005579 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1111678005580 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1111678005581 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1111678005582 Similar to hypothetical protein; predicted non-functional due to TAA stop codon 1111678005583 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 1111678005584 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1111678005585 motif II; other site 1111678005586 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 1111678005587 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 1111678005588 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 1111678005589 Protein of unknown function (DUF1033); Region: DUF1033; pfam06279 1111678005590 Ribonuclease III family protein [Replication, recombination, and repair]; Region: COG1939 1111678005591 active site 1111678005592 metal binding site [ion binding]; metal-binding site 1111678005593 dimerization interface [polypeptide binding]; other site 1111678005594 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1111678005595 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1111678005596 active site 1111678005597 HIGH motif; other site 1111678005598 KMSKS motif; other site 1111678005599 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1111678005600 tRNA binding surface [nucleotide binding]; other site 1111678005601 anticodon binding site; other site 1111678005602 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 1111678005603 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 1111678005604 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1111678005605 trimer interface [polypeptide binding]; other site 1111678005606 active site 1111678005607 substrate binding site [chemical binding]; other site 1111678005608 CoA binding site [chemical binding]; other site 1111678005609 Domain of unknown function (DUF4343); Region: DUF4343; pfam14243 1111678005610 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 1111678005611 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 1111678005612 RNase E interface [polypeptide binding]; other site 1111678005613 trimer interface [polypeptide binding]; other site 1111678005614 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1111678005615 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1111678005616 RNase E interface [polypeptide binding]; other site 1111678005617 trimer interface [polypeptide binding]; other site 1111678005618 active site 1111678005619 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1111678005620 putative nucleic acid binding region [nucleotide binding]; other site 1111678005621 G-X-X-G motif; other site 1111678005622 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1111678005623 RNA binding site [nucleotide binding]; other site 1111678005624 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02458 1111678005625 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1111678005626 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1111678005627 active site 1111678005628 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1111678005629 Ligand Binding Site [chemical binding]; other site 1111678005630 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1111678005631 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1111678005632 catalytic residue [active] 1111678005633 Putative amino acid metabolizm; Region: DUF1831; pfam08866 1111678005634 elongation factor Tu; Reviewed; Region: PRK00049 1111678005635 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1111678005636 G1 box; other site 1111678005637 GEF interaction site [polypeptide binding]; other site 1111678005638 GTP/Mg2+ binding site [chemical binding]; other site 1111678005639 Switch I region; other site 1111678005640 G2 box; other site 1111678005641 G3 box; other site 1111678005642 Switch II region; other site 1111678005643 G4 box; other site 1111678005644 G5 box; other site 1111678005645 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1111678005646 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1111678005647 Antibiotic Binding Site [chemical binding]; other site 1111678005648 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 1111678005649 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1111678005650 active site 1111678005651 HIGH motif; other site 1111678005652 KMSKS motif; other site 1111678005653 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 1111678005654 tRNA binding surface [nucleotide binding]; other site 1111678005655 anticodon binding site; other site 1111678005656 DivIVA protein; Region: DivIVA; pfam05103 1111678005657 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 1111678005658 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 1111678005659 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1111678005660 RNA binding surface [nucleotide binding]; other site 1111678005661 YGGT family; Region: YGGT; pfam02325 1111678005662 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 1111678005663 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 1111678005664 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1111678005665 catalytic residue [active] 1111678005666 cell division protein FtsZ; Validated; Region: PRK09330 1111678005667 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1111678005668 nucleotide binding site [chemical binding]; other site 1111678005669 SulA interaction site; other site 1111678005670 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 1111678005671 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1111678005672 nucleotide binding site [chemical binding]; other site 1111678005673 Cell division protein FtsA; Region: FtsA; pfam14450 1111678005674 Domain of unknown function (DUF3484); Region: DUF3484; pfam11983 1111678005675 EDD domain protein, DegV family; Region: DegV; TIGR00762 1111678005676 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1111678005677 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1111678005678 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1111678005679 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1111678005680 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1111678005681 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 1111678005682 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1111678005683 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1111678005684 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 1111678005685 active site 1111678005686 catalytic tetrad [active] 1111678005687 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1111678005688 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1111678005689 putative substrate translocation pore; other site 1111678005690 Similar to LysR family transcription regulator; predicted non-functional due to frameshift 1111678005691 transcriptional regulator, MerR family 1111678005692 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 1111678005693 trimer interface [polypeptide binding]; other site 1111678005694 active site 1111678005695 G bulge; other site 1111678005696 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1111678005697 Zn2+ binding site [ion binding]; other site 1111678005698 Mg2+ binding site [ion binding]; other site 1111678005699 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 1111678005700 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 1111678005701 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1111678005702 dimer interface [polypeptide binding]; other site 1111678005703 ADP-ribose binding site [chemical binding]; other site 1111678005704 active site 1111678005705 nudix motif; other site 1111678005706 metal binding site [ion binding]; metal-binding site 1111678005707 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 1111678005708 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1111678005709 Substrate binding site; other site 1111678005710 Mg++ binding site; other site 1111678005711 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1111678005712 active site 1111678005713 substrate binding site [chemical binding]; other site 1111678005714 CoA binding site [chemical binding]; other site 1111678005715 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 1111678005716 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 1111678005717 Pyrroline-5-carboxylate reductase dimerization; Region: P5CR_dimer; pfam14748 1111678005718 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1111678005719 16S/18S rRNA binding site [nucleotide binding]; other site 1111678005720 S13e-L30e interaction site [polypeptide binding]; other site 1111678005721 25S rRNA binding site [nucleotide binding]; other site 1111678005722 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1111678005723 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1111678005724 active site 1111678005725 ATP binding site [chemical binding]; other site 1111678005726 substrate binding site [chemical binding]; other site 1111678005727 activation loop (A-loop); other site 1111678005728 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1111678005729 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1111678005730 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1111678005731 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1111678005732 active site 1111678005733 16S rRNA methyltransferase B; Provisional; Region: PRK14902 1111678005734 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 1111678005735 putative RNA binding site [nucleotide binding]; other site 1111678005736 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1111678005737 S-adenosylmethionine binding site [chemical binding]; other site 1111678005738 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1111678005739 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1111678005740 Ligand binding site; other site 1111678005741 Putative Catalytic site; other site 1111678005742 DXD motif; other site 1111678005743 conserved hypothetical integral membrane protein; Region: TIGR03766 1111678005744 HTH-like domain; Region: HTH_21; pfam13276 1111678005745 Integrase core domain; Region: rve; pfam00665 1111678005746 Integrase core domain; Region: rve_3; cl15866 1111678005747 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1111678005748 Transposase; Region: HTH_Tnp_1; pfam01527 1111678005749 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1111678005750 trimer interface [polypeptide binding]; other site 1111678005751 active site 1111678005752 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1111678005753 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1111678005754 Walker A motif; other site 1111678005755 ATP binding site [chemical binding]; other site 1111678005756 Walker B motif; other site 1111678005757 arginine finger; other site 1111678005758 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1111678005759 Integrase core domain; Region: rve; pfam00665 1111678005760 Phox homology (PX) domain protein [Intracellular trafficking and secretion / General function prediction only]; Region: COG5391 1111678005761 aminotransferase; Validated; Region: PRK07777 1111678005762 Domain of unknown function (DUF955); Region: DUF955; cl01076 1111678005763 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1111678005764 Phage integrase, N-terminal SAM-like domain; Region: Phage_int_SAM_3; pfam14659 1111678005765 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 1111678005766 Int/Topo IB signature motif; other site 1111678005767 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 1111678005768 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1111678005769 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1111678005770 putative active site [active] 1111678005771 substrate binding site [chemical binding]; other site 1111678005772 putative cosubstrate binding site; other site 1111678005773 catalytic site [active] 1111678005774 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1111678005775 substrate binding site [chemical binding]; other site 1111678005776 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1111678005777 dimer interface [polypeptide binding]; other site 1111678005778 Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684 1111678005779 nudix motif; other site 1111678005780 SnoaL-like domain; Region: SnoaL_2; pfam12680 1111678005781 Similar to hypothetical protein; predicted non-functiona due to TAG stop codon 1111678005782 primosome assembly protein PriA; Validated; Region: PRK05580 1111678005783 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1111678005784 ATP binding site [chemical binding]; other site 1111678005785 putative Mg++ binding site [ion binding]; other site 1111678005786 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1111678005787 nucleotide binding region [chemical binding]; other site 1111678005788 ATP-binding site [chemical binding]; other site 1111678005789 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 1111678005790 Guanylate kinase; Region: Guanylate_kin; pfam00625 1111678005791 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1111678005792 catalytic site [active] 1111678005793 G-X2-G-X-G-K; other site 1111678005794 phosphodiesterase; Provisional; Region: PRK12704 1111678005795 core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_like; cl19107 1111678005796 Conserved oligomeric complex COG6; Region: COG6; cl19764 1111678005797 KH domain; Region: KH_1; pfam00013 1111678005798 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1111678005799 Zn2+ binding site [ion binding]; other site 1111678005800 Mg2+ binding site [ion binding]; other site 1111678005801 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1111678005802 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 1111678005803 active site 1111678005804 trimer interface [polypeptide binding]; other site 1111678005805 allosteric site; other site 1111678005806 active site lid [active] 1111678005807 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1111678005808 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1111678005809 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1111678005810 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1111678005811 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 1111678005812 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1111678005813 S-adenosylmethionine binding site [chemical binding]; other site 1111678005814 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 1111678005815 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 1111678005816 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 1111678005817 Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983 1111678005818 Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983 1111678005819 Uncharacterized conserved protein [Function unknown]; Region: COG3595 1111678005820 Domain of unknown function (DUF4098); Region: DUF4098; cl19992 1111678005821 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 1111678005822 N-acetylmuramoyl-L-alanine amidase; Validated; Region: PRK08581 1111678005823 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 1111678005824 CHAP domain; Region: CHAP; pfam05257 1111678005825 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1111678005826 intersubunit interface [polypeptide binding]; other site 1111678005827 active site 1111678005828 zinc binding site [ion binding]; other site 1111678005829 Na+ binding site [ion binding]; other site 1111678005830 Predicted membrane protein [Function unknown]; Region: COG2860 1111678005831 UPF0126 domain; Region: UPF0126; pfam03458 1111678005832 UPF0126 domain; Region: UPF0126; pfam03458 1111678005833 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 1111678005834 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1111678005835 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1111678005836 active site 1111678005837 dimer interface [polypeptide binding]; other site 1111678005838 motif 1; other site 1111678005839 motif 2; other site 1111678005840 motif 3; other site 1111678005841 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1111678005842 anticodon binding site; other site 1111678005843 ATP cone domain; Region: ATP-cone; pfam03477 1111678005844 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 1111678005845 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1111678005846 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 1111678005847 dimer interface [polypeptide binding]; other site 1111678005848 FMN binding site [chemical binding]; other site 1111678005849 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1111678005850 active site 1111678005851 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1111678005852 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1111678005853 putative C-S lyase; Region: C_S_lyase_PatB; TIGR04350 1111678005854 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1111678005855 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1111678005856 homodimer interface [polypeptide binding]; other site 1111678005857 catalytic residue [active] 1111678005858 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1111678005859 homodimer interface [polypeptide binding]; other site 1111678005860 substrate-cofactor binding pocket; other site 1111678005861 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1111678005862 catalytic residue [active] 1111678005863 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 1111678005864 proposed active site lysine [active] 1111678005865 conserved cys residue [active] 1111678005866 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674 1111678005867 nudix motif; other site 1111678005868 Predicted permeases [General function prediction only]; Region: COG0679 1111678005869 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 1111678005870 active site 1111678005871 catalytic residues [active] 1111678005872 Predicted HD-superfamily hydrolase [General function prediction only]; Region: COG3481 1111678005873 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 1111678005874 generic binding surface II; other site 1111678005875 generic binding surface I; other site 1111678005876 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1111678005877 Zn2+ binding site [ion binding]; other site 1111678005878 Mg2+ binding site [ion binding]; other site 1111678005879 Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322 1111678005880 RmuC family; Region: RmuC; pfam02646 1111678005881 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 1111678005882 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1111678005883 substrate binding site [chemical binding]; other site 1111678005884 hexamer interface [polypeptide binding]; other site 1111678005885 metal binding site [ion binding]; metal-binding site 1111678005886 GTPase RsgA; Reviewed; Region: PRK00098 1111678005887 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 1111678005888 RNA binding site [nucleotide binding]; other site 1111678005889 homodimer interface [polypeptide binding]; other site 1111678005890 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1111678005891 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1111678005892 GTP/Mg2+ binding site [chemical binding]; other site 1111678005893 G4 box; other site 1111678005894 G1 box; other site 1111678005895 Switch I region; other site 1111678005896 G2 box; other site 1111678005897 G3 box; other site 1111678005898 Switch II region; other site 1111678005899 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 1111678005900 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 1111678005901 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1111678005902 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1111678005903 putative tRNA-binding site [nucleotide binding]; other site 1111678005904 B3/4 domain; Region: B3_4; pfam03483 1111678005905 tRNA synthetase B5 domain; Region: B5; smart00874 1111678005906 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1111678005907 dimer interface [polypeptide binding]; other site 1111678005908 motif 1; other site 1111678005909 motif 3; other site 1111678005910 motif 2; other site 1111678005911 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 1111678005912 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1111678005913 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1111678005914 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1111678005915 dimer interface [polypeptide binding]; other site 1111678005916 motif 1; other site 1111678005917 active site 1111678005918 motif 2; other site 1111678005919 motif 3; other site 1111678005920 Phenolic Acid Decarboxylase; Region: PAD; cd14241 1111678005921 active site 1111678005922 dimer interface [polypeptide binding]; other site 1111678005923 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1111678005924 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1111678005925 Similar to negative regulator of phenolic ac metabolism PadR; predicted non-functional due to frameshift 1111678005926 GH18 domain of Chitinase D (ChiD). ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins. The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871 1111678005927 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 1111678005928 putative active site [active] 1111678005929 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 1111678005930 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 1111678005931 aromatic chitin/cellulose binding site residues [chemical binding]; other site 1111678005932 Chitin binding domain; Region: Chitin_bind_3; pfam03067 1111678005933 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1111678005934 GDP-binding site [chemical binding]; other site 1111678005935 ACT binding site; other site 1111678005936 IMP binding site; other site 1111678005937 Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300 1111678005938 Cadmium resistance transporter; Region: Cad; pfam03596 1111678005939 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 1111678005940 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 1111678005941 dimerization interface [polypeptide binding]; other site 1111678005942 domain crossover interface; other site 1111678005943 redox-dependent activation switch; other site 1111678005944 Similar to dihydrofolate reductase family protein; predicted non-functional due to frameshift 1111678005945 Protein of unknown function (DUF805); Region: DUF805; pfam05656 1111678005946 Similar to hypothetical protein; predicted non-functional due to frameshift 1111678005947 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 1111678005948 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1111678005949 FMN binding site [chemical binding]; other site 1111678005950 active site 1111678005951 catalytic residues [active] 1111678005952 substrate binding site [chemical binding]; other site 1111678005953 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1111678005954 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1111678005955 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1111678005956 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1111678005957 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1111678005958 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1111678005959 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1111678005960 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1111678005961 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1111678005962 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1111678005963 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1111678005964 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1111678005965 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1111678005966 dimer interface [polypeptide binding]; other site 1111678005967 anticodon binding site; other site 1111678005968 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1111678005969 homodimer interface [polypeptide binding]; other site 1111678005970 motif 1; other site 1111678005971 active site 1111678005972 motif 2; other site 1111678005973 GAD domain; Region: GAD; pfam02938 1111678005974 motif 3; other site 1111678005975 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 1111678005976 nucleotide binding site/active site [active] 1111678005977 HIT family signature motif; other site 1111678005978 catalytic residue [active] 1111678005979 histidyl-tRNA synthetase; Region: hisS; TIGR00442 1111678005980 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1111678005981 dimer interface [polypeptide binding]; other site 1111678005982 motif 1; other site 1111678005983 active site 1111678005984 motif 2; other site 1111678005985 motif 3; other site 1111678005986 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1111678005987 anticodon binding site; other site 1111678005988 Similar to hypothetical protein; predicted non-functional due to frameshift 1111678005989 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 1111678005990 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 1111678005991 Helix-turn-helix domain; Region: HTH_25; pfam13413 1111678005992 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1111678005993 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1111678005994 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1111678005995 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1111678005996 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1111678005997 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1111678005998 RNA binding surface [nucleotide binding]; other site 1111678005999 recF protein; Region: recf; TIGR00611 1111678006000 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 1111678006001 Walker A/P-loop; other site 1111678006002 ATP binding site [chemical binding]; other site 1111678006003 Q-loop/lid; other site 1111678006004 ABC transporter signature motif; other site 1111678006005 Walker B; other site 1111678006006 D-loop; other site 1111678006007 H-loop/switch region; other site 1111678006008 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1111678006009 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1111678006010 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 1111678006011 DNA binding residues [nucleotide binding] 1111678006012 putative dimer interface [polypeptide binding]; other site 1111678006013 Putative lysophospholipase; Region: Hydrolase_4; cl19140 1111678006014 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 1111678006015 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 1111678006016 NAD binding site [chemical binding]; other site 1111678006017 homodimer interface [polypeptide binding]; other site 1111678006018 active site 1111678006019 substrate binding site [chemical binding]; other site 1111678006020 galactose-1-phosphate uridylyltransferase, family 2; Region: galT_2; TIGR01239 1111678006021 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 1111678006022 Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744 1111678006023 galactokinase; Provisional; Region: PRK05322 1111678006024 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 1111678006025 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1111678006026 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 1111678006027 active site 1111678006028 catalytic residues [active] 1111678006029 putative symporter YagG; Provisional; Region: PRK09669; cl15392 1111678006030 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 1111678006031 Similiar to Phosphosugar-binding transcriptional repressor, RpiR family; predicted non-functional due to frameshift 1111678006032 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1111678006033 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1111678006034 Similar to aerobic energy metabolism protein; predicted non-functional due to frameshift 1111678006035 nicotinamide-nucleotide adenylyltransferase, NadR type; Region: nadR_NMN_Atrans; TIGR01526 1111678006036 Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional NadR-like proteins; Region: NMNAT_NadR; cd02167 1111678006037 active site 1111678006038 (T/H)XGH motif; other site 1111678006039 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 1111678006040 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1111678006041 Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300 1111678006042 NAD binding site [chemical binding]; other site 1111678006043 ligand binding site [chemical binding]; other site 1111678006044 catalytic site [active] 1111678006045 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1111678006046 putative protease; Provisional; Region: PRK15452 1111678006047 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1111678006048 Protein of unknown function (DUF3270); Region: DUF3270; pfam11674 1111678006049 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 1111678006050 Methyltransferase domain; Region: Methyltransf_11; pfam08241 1111678006051 CutC family; Region: CutC; pfam03932 1111678006052 Predicted ABC-type exoprotein transport system, permease component [Intracellular trafficking and secretion]; Region: EcsB; COG4473 1111678006053 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1111678006054 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1111678006055 Walker A/P-loop; other site 1111678006056 ATP binding site [chemical binding]; other site 1111678006057 Q-loop/lid; other site 1111678006058 ABC transporter signature motif; other site 1111678006059 Walker B; other site 1111678006060 D-loop; other site 1111678006061 H-loop/switch region; other site 1111678006062 Similar to Glycerophosphoryl diester phosphodiesterase, predicted non-functional due to truncation 1111678006063 putative transposase OrfB; Reviewed; Region: PHA02517 1111678006064 HTH-like domain; Region: HTH_21; pfam13276 1111678006065 Integrase core domain; Region: rve; pfam00665 1111678006066 Integrase core domain; Region: rve_3; pfam13683 1111678006067 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1111678006068 Transposase; Region: HTH_Tnp_1; pfam01527 1111678006069 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 1111678006070 HIT family signature motif; other site 1111678006071 catalytic residue [active] 1111678006072 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1111678006073 mRNA/rRNA interface [nucleotide binding]; other site 1111678006074 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1111678006075 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1111678006076 23S rRNA interface [nucleotide binding]; other site 1111678006077 L7/L12 interface [polypeptide binding]; other site 1111678006078 putative thiostrepton binding site; other site 1111678006079 L25 interface [polypeptide binding]; other site 1111678006080 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1111678006081 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1111678006082 Walker A/P-loop; other site 1111678006083 ATP binding site [chemical binding]; other site 1111678006084 Q-loop/lid; other site 1111678006085 ABC transporter signature motif; other site 1111678006086 Walker B; other site 1111678006087 D-loop; other site 1111678006088 H-loop/switch region; other site 1111678006089 Protein of unknown function (DUF1250); Region: DUF1250; cl11485 1111678006090 methionine sulfoxide reductase A; Provisional; Region: PRK14054 1111678006091 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 1111678006092 S1 domain; Region: S1_2; pfam13509 1111678006093 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1111678006094 RNA binding site [nucleotide binding]; other site 1111678006095 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 1111678006096 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1111678006097 Coenzyme A binding pocket [chemical binding]; other site 1111678006098 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1111678006099 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1111678006100 hinge region; other site 1111678006101 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1111678006102 putative nucleotide binding site [chemical binding]; other site 1111678006103 uridine monophosphate binding site [chemical binding]; other site 1111678006104 homohexameric interface [polypeptide binding]; other site 1111678006105 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 1111678006106 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 1111678006107 propionate/acetate kinase; Provisional; Region: PRK12379 1111678006108 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 1111678006109 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1111678006110 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 1111678006111 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1111678006112 G1 box; other site 1111678006113 putative GEF interaction site [polypeptide binding]; other site 1111678006114 GTP/Mg2+ binding site [chemical binding]; other site 1111678006115 Switch I region; other site 1111678006116 G2 box; other site 1111678006117 G3 box; other site 1111678006118 Switch II region; other site 1111678006119 G4 box; other site 1111678006120 G5 box; other site 1111678006121 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1111678006122 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1111678006123 putative transposase OrfB; Reviewed; Region: PHA02517 1111678006124 HTH-like domain; Region: HTH_21; pfam13276 1111678006125 Integrase core domain; Region: rve; pfam00665 1111678006126 Integrase core domain; Region: rve_3; pfam13683 1111678006127 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1111678006128 Transposase; Region: HTH_Tnp_1; pfam01527 1111678006129 Similar to hypothetical protein; predicted non-functional due to truncation 1111678006130 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1111678006131 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1111678006132 LytTr DNA-binding domain; Region: LytTR; cl04498 1111678006133 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4483 1111678006134 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 1111678006135 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1111678006136 nucleotide binding site [chemical binding]; other site 1111678006137 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1111678006138 Ferritin-like domain; Region: Ferritin; pfam00210 1111678006139 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1111678006140 dimerization interface [polypeptide binding]; other site 1111678006141 DPS ferroxidase diiron center [ion binding]; other site 1111678006142 ion pore; other site 1111678006143 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 1111678006144 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 1111678006145 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1111678006146 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1111678006147 DNA polymerase IV; Validated; Region: PRK02406 1111678006148 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1111678006149 active site 1111678006150 DNA binding site [nucleotide binding] 1111678006151 This CD includes bacterial (Agrobacterium tumefaciens and Caulobacter crescentus ProX, and Clostridium sticklandii PrdX) and eukaryotic (Plasmodium falciparum N-terminal ProRS editing domain) sequences. The C. sticklandii PrdX protein, a homolog of the...; Region: PrdX_deacylase; cd04335 1111678006152 putative deacylase active site [active] 1111678006153 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 1111678006154 Similar to transaminase; predicted non-functional due to TAA stop codon 1111678006155 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 1111678006156 putative substrate binding site [chemical binding]; other site 1111678006157 nucleotide binding site [chemical binding]; other site 1111678006158 nucleotide binding site [chemical binding]; other site 1111678006159 homodimer interface [polypeptide binding]; other site 1111678006160 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 1111678006161 ornithine carbamoyltransferase; Validated; Region: PRK02102 1111678006162 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1111678006163 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1111678006164 Amidinotransferase; Region: Amidinotransf; cl19186 1111678006165 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1111678006166 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1111678006167 arginyl-tRNA synthetase; Reviewed; Region: PRK12451 1111678006168 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 1111678006169 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1111678006170 active site 1111678006171 HIGH motif; other site 1111678006172 KMSK motif region; other site 1111678006173 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 1111678006174 tRNA binding surface [nucleotide binding]; other site 1111678006175 anticodon binding site; other site 1111678006176 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1111678006177 arginine repressor; Region: argR_whole; TIGR01529 1111678006178 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1111678006179 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1111678006180 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1111678006181 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1111678006182 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1111678006183 SWIM zinc finger; Region: SWIM; pfam04434 1111678006184 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 1111678006185 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 1111678006186 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1111678006187 ATP binding site [chemical binding]; other site 1111678006188 putative Mg++ binding site [ion binding]; other site 1111678006189 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1111678006190 nucleotide binding region [chemical binding]; other site 1111678006191 ATP-binding site [chemical binding]; other site 1111678006192 Similar to conjugative transposon Tn5276 integrase; predicted non-functional due to frameshift 1111678006193 Similar to Tn981 transposase; predicted non-functional due to frameshift 1111678006194 Beta-lactamase; Region: Beta-lactamase; pfam00144 1111678006195 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1111678006196 CppA C-terminal; Region: CppA_C; pfam14507 1111678006197 Domain of unknown function (DU1801); Region: DUF1801; cl17490 1111678006198 Similar to flavin-nucleotide-binding protein; predicted non-functional due to TAG stop codon 1111678006199 CAAX protease self-immunity; Region: Abi; pfam02517 1111678006200 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 1111678006201 amphipathic channel; other site 1111678006202 Asn-Pro-Ala signature motifs; other site 1111678006203 x-prolyl-dipeptidyl aminopeptidase; Provisional; Region: PRK05371 1111678006204 X-Prolyl dipeptidyl aminopeptidase PepX, N-terminal; Region: PepX_N; smart00940 1111678006205 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 1111678006206 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 1111678006207 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 1111678006208 catalytic triad [active] 1111678006209 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1111678006210 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1111678006211 substrate binding pocket [chemical binding]; other site 1111678006212 membrane-bound complex binding site; other site 1111678006213 hinge residues; other site 1111678006214 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK08010 1111678006215 TrkA-N domain; Region: TrkA_N; pfam02254 1111678006216 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1111678006217 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 1111678006218 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1111678006219 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1111678006220 active site 1111678006221 HIGH motif; other site 1111678006222 KMSKS motif; other site 1111678006223 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 1111678006224 catalytic triad [active] 1111678006225 conserved cis-peptide bond; other site 1111678006226 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 1111678006227 catalytic triad [active] 1111678006228 conserved cis-peptide bond; other site 1111678006229 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1111678006230 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1111678006231 Similar to hypothetical protein; predicted non-functional due to TAG stop codon 1111678006232 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1111678006233 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1111678006234 Coenzyme A binding pocket [chemical binding]; other site 1111678006235 DNA-binding ferritin-like protein (Dps family) [General function prediction only]; Region: COG4817 1111678006236 Protein of unknown function (DUF1048); Region: DUF1048; pfam06304 1111678006237 Predicted transcriptional regulators [Transcription]; Region: COG1695 1111678006238 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1111678006239 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 1111678006240 Sulfite exporter TauE/SafE; Region: TauE; cl19196 1111678006241 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 1111678006242 putative active site [active] 1111678006243 Predicted membrane protein [Function unknown]; Region: COG3619 1111678006244 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1111678006245 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1111678006246 DNA repair protein RadA; Provisional; Region: PRK11823 1111678006247 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 1111678006248 Walker A motif/ATP binding site; other site 1111678006249 ATP binding site [chemical binding]; other site 1111678006250 Walker B motif; other site 1111678006251 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1111678006252 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 1111678006253 active site 1111678006254 histidinol-phosphatase; Region: hisB_Nterm; TIGR01261 1111678006255 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1111678006256 active site 1111678006257 motif I; other site 1111678006258 motif II; other site 1111678006259 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1111678006260 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 1111678006261 dimer interface [polypeptide binding]; other site 1111678006262 active site 1111678006263 Similar to D-glycero-D-manno-heptose 7-phosphate kinase; predicted non-functional due to frameshift 1111678006264 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1111678006265 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1111678006266 Similar to Glycosyltransferase, family 2; predicted non-functional due to frameshift 1111678006267 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1111678006268 active site 1111678006269 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1111678006270 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1111678006271 active site 1111678006272 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1111678006273 FemAB family; Region: FemAB; pfam02388 1111678006274 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1111678006275 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1111678006276 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1111678006277 alphaNTD homodimer interface [polypeptide binding]; other site 1111678006278 alphaNTD - beta interaction site [polypeptide binding]; other site 1111678006279 alphaNTD - beta' interaction site [polypeptide binding]; other site 1111678006280 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1111678006281 30S ribosomal protein S11; Validated; Region: PRK05309 1111678006282 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 1111678006283 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1111678006284 rRNA binding site [nucleotide binding]; other site 1111678006285 predicted 30S ribosome binding site; other site 1111678006286 adenylate kinase; Reviewed; Region: adk; PRK00279 1111678006287 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1111678006288 AMP-binding site [chemical binding]; other site 1111678006289 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1111678006290 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1111678006291 SecY translocase; Region: SecY; pfam00344 1111678006292 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1111678006293 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1111678006294 23S rRNA binding site [nucleotide binding]; other site 1111678006295 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1111678006296 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1111678006297 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1111678006298 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1111678006299 5S rRNA interface [nucleotide binding]; other site 1111678006300 L27 interface [polypeptide binding]; other site 1111678006301 23S rRNA interface [nucleotide binding]; other site 1111678006302 L5 interface [polypeptide binding]; other site 1111678006303 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1111678006304 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1111678006305 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1111678006306 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1111678006307 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 1111678006308 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1111678006309 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1111678006310 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1111678006311 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1111678006312 RNA binding site [nucleotide binding]; other site 1111678006313 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1111678006314 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1111678006315 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1111678006316 23S rRNA interface [nucleotide binding]; other site 1111678006317 putative translocon interaction site; other site 1111678006318 signal recognition particle (SRP54) interaction site; other site 1111678006319 L23 interface [polypeptide binding]; other site 1111678006320 trigger factor interaction site; other site 1111678006321 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1111678006322 23S rRNA interface [nucleotide binding]; other site 1111678006323 5S rRNA interface [nucleotide binding]; other site 1111678006324 putative antibiotic binding site [chemical binding]; other site 1111678006325 L25 interface [polypeptide binding]; other site 1111678006326 L27 interface [polypeptide binding]; other site 1111678006327 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1111678006328 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1111678006329 G-X-X-G motif; other site 1111678006330 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1111678006331 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1111678006332 putative translocon binding site; other site 1111678006333 protein-rRNA interface [nucleotide binding]; other site 1111678006334 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1111678006335 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1111678006336 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1111678006337 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1111678006338 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1111678006339 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1111678006340 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 1111678006341 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1111678006342 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1111678006343 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1111678006344 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1111678006345 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1111678006346 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1111678006347 threonine synthase; Validated; Region: PRK09225 1111678006348 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 1111678006349 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1111678006350 catalytic residue [active] 1111678006351 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1111678006352 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1111678006353 putative homodimer interface [polypeptide binding]; other site 1111678006354 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1111678006355 heterodimer interface [polypeptide binding]; other site 1111678006356 homodimer interface [polypeptide binding]; other site 1111678006357 Preprotein translocase subunit SecE [Intracellular trafficking and secretion]; Region: SecE; COG0690 1111678006358 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 1111678006359 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1111678006360 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 1111678006361 catalytic triad [active] 1111678006362 catalytic triad [active] 1111678006363 oxyanion hole [active] 1111678006364 Transglycosylase; Region: Transgly; pfam00912 1111678006365 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1111678006366 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1111678006367 Predicted membrane protein [Function unknown]; Region: COG2323 1111678006368 Protein of unknown function (DUF3290); Region: DUF3290; pfam11694 1111678006369 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1111678006370 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1111678006371 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1111678006372 active site 1111678006373 putative transposase OrfB; Reviewed; Region: PHA02517 1111678006374 HTH-like domain; Region: HTH_21; pfam13276 1111678006375 Integrase core domain; Region: rve; pfam00665 1111678006376 Integrase core domain; Region: rve_2; pfam13333 1111678006377 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1111678006378 Helix-turn-helix domain; Region: HTH_28; pfam13518 1111678006379 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1111678006380 Transposase; Region: HTH_Tnp_1; cl17663 1111678006381 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1111678006382 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1111678006383 ABC-ATPase subunit interface; other site 1111678006384 dimer interface [polypeptide binding]; other site 1111678006385 putative PBP binding regions; other site 1111678006386 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1111678006387 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1111678006388 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 1111678006389 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 1111678006390 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 1111678006391 metal binding site [ion binding]; metal-binding site 1111678006392 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1111678006393 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1111678006394 putative DNA binding site [nucleotide binding]; other site 1111678006395 putative Zn2+ binding site [ion binding]; other site 1111678006397 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 1111678006398 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 1111678006399 Type II secretory pathway pseudopilin; Region: PulG; pfam11773 1111678006400 Similar to competence protein ComGD; predicted non-functional due to frameshift 1111678006401 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 1111678006402 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 1111678006403 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1111678006404 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1111678006405 Walker A motif; other site 1111678006406 ATP binding site [chemical binding]; other site 1111678006407 Walker B motif; other site 1111678006408 DNA polymerase III PolC; Validated; Region: polC; PRK00448 1111678006409 DNA polymerase III polC-type N-terminus I; Region: DNA_pol3_a_NI; pfam14480 1111678006410 DNA polymerase III polC-type N-terminus II; Region: DNA_pol3_a_NII; pfam11490 1111678006411 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 1111678006412 generic binding surface II; other site 1111678006413 generic binding surface I; other site 1111678006414 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 1111678006415 generic binding surface II; other site 1111678006416 generic binding surface I; other site 1111678006417 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 1111678006418 active site 1111678006419 putative PHP Thumb interface [polypeptide binding]; other site 1111678006420 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1111678006421 active site 1111678006422 catalytic site [active] 1111678006423 substrate binding site [chemical binding]; other site 1111678006424 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 1111678006425 Helix-hairpin-helix motif; Region: HHH_6; pfam14579 1111678006426 Similar to hypothetical protein; predicted non-functional due to truncation 1111678006427 Similar to NAD(FAD)-dependent dehydrogenase; predicted non-functional due to TAA stop codon 1111678006428 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1111678006429 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1111678006430 motif 1; other site 1111678006431 dimer interface [polypeptide binding]; other site 1111678006432 active site 1111678006433 motif 2; other site 1111678006434 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 1111678006435 putative deacylase active site [active] 1111678006436 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1111678006437 active site 1111678006438 motif 3; other site 1111678006439 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1111678006440 anticodon binding site; other site 1111678006441 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1111678006442 RIP metalloprotease RseP; Region: TIGR00054 1111678006443 active site 1111678006444 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1111678006445 protein binding site [polypeptide binding]; other site 1111678006446 putative substrate binding region [chemical binding]; other site 1111678006447 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1111678006448 Cis (Z)-Isoprenyl Diphosphate Synthases; Region: Cis_IPPS; cd00475 1111678006449 active site 1111678006450 dimer interface [polypeptide binding]; other site 1111678006451 Preprotein translocase subunit; Region: YajC; cl00806 1111678006452 Similar to DNA-7-methylguanine glycosylase; predicted non-functional due to frameshift 1111678006453 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 1111678006454 periplasmic serine pepetdase DegS; Region: protease_degS; TIGR02038 1111678006455 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1111678006456 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1111678006457 protein binding site [polypeptide binding]; other site 1111678006458 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1111678006459 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1111678006460 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1111678006461 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 1111678006462 putative ADP-binding pocket [chemical binding]; other site 1111678006463 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4703 1111678006464 Similar to hypothetical protein; predicted non-functional due to frameshift 1111678006465 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 1111678006466 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1111678006467 S-adenosylmethionine binding site [chemical binding]; other site 1111678006468 DNA polymerase I; Provisional; Region: PRK05755 1111678006469 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1111678006470 active site 1111678006471 metal binding site 1 [ion binding]; metal-binding site 1111678006472 putative 5' ssDNA interaction site; other site 1111678006473 metal binding site 3; metal-binding site 1111678006474 metal binding site 2 [ion binding]; metal-binding site 1111678006475 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1111678006476 putative DNA binding site [nucleotide binding]; other site 1111678006477 putative metal binding site [ion binding]; other site 1111678006478 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 1111678006479 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1111678006480 active site 1111678006481 DNA binding site [nucleotide binding] 1111678006482 catalytic site [active] 1111678006483 Similar to Hydrolase (HAD superfamily); predicted non-functional due to frameshift 1111678006484 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1111678006485 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1111678006486 DNA binding site [nucleotide binding] 1111678006487 domain linker motif; other site 1111678006488 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1111678006489 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1111678006490 Negative regulator of septation ring formation [Cell division and chromosome partitioning]; Region: EzrA; COG4477 1111678006491 Violaxanthin de-epoxidase (VDE); Region: VDE; cl06253 1111678006492 elongation factor Ts; Provisional; Region: tsf; PRK09377 1111678006493 UBA/TS-N domain; Region: UBA; pfam00627 1111678006494 Elongation factor TS; Region: EF_TS; pfam00889 1111678006495 Elongation factor TS; Region: EF_TS; pfam00889 1111678006496 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1111678006497 rRNA interaction site [nucleotide binding]; other site 1111678006498 S8 interaction site; other site 1111678006499 putative laminin-1 binding site; other site 1111678006500 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1111678006501 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1111678006502 3-carboxymuconate cyclase [Carbohydrate transport and metabolism]; Region: COG2706 1111678006503 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 1111678006504 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 1111678006505 putative catalytic cysteine [active] 1111678006506 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 1111678006507 putative active site [active] 1111678006508 metal binding site [ion binding]; metal-binding site 1111678006509 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 1111678006510 dimer interface [polypeptide binding]; other site 1111678006511 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1111678006512 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1111678006513 KxxxW cyclic peptide radical SAM maturase; Region: rSAM_pep_cyc; TIGR04080 1111678006514 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1111678006515 FeS/SAM binding site; other site 1111678006516 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1111678006517 KxxxW-cyclized secreted peptide; Region: phero_cyc_pep; TIGR04079 1111678006518 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 1111678006519 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 1111678006520 protein binding site [polypeptide binding]; other site 1111678006521 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1111678006522 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1111678006523 active site 1111678006524 (T/H)XGH motif; other site 1111678006525 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 1111678006526 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1111678006527 S-adenosylmethionine binding site [chemical binding]; other site 1111678006528 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1111678006529 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1111678006530 putative substrate translocation pore; other site 1111678006531 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1111678006532 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1111678006533 DNA binding residues [nucleotide binding] 1111678006534 Sigma factor regulator N-terminal; Region: Sigma_reg_N; pfam13800 1111678006535 Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791 1111678006536 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 1111678006537 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1111678006538 active site 1111678006539 dimer interface [polypeptide binding]; other site 1111678006540 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1111678006541 dimer interface [polypeptide binding]; other site 1111678006542 active site 1111678006543 Flagellin N-methylase; Region: FliB; pfam03692 1111678006544 Similar to Short-chain alcohol dehydrogenase; predicted non-functional due to frameshift 1111678006545 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1111678006546 non-specific DNA binding site [nucleotide binding]; other site 1111678006547 salt bridge; other site 1111678006548 sequence-specific DNA binding site [nucleotide binding]; other site 1111678006549 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1111678006550 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1111678006551 NAD(P) binding site [chemical binding]; other site 1111678006552 active site 1111678006553 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1111678006554 putative DNA binding site [nucleotide binding]; other site 1111678006555 dimerization interface [polypeptide binding]; other site 1111678006556 putative Zn2+ binding site [ion binding]; other site 1111678006557 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1111678006558 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1111678006559 active site 1111678006560 HIGH motif; other site 1111678006561 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1111678006562 KMSKS motif; other site 1111678006563 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1111678006564 tRNA binding surface [nucleotide binding]; other site 1111678006565 anticodon binding site; other site 1111678006566 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1111678006567 Fibronectin-binding protein (FBP); Region: FBP; pfam07299 1111678006568 Domain of unknown function (DUF1912); Region: DUF1912; pfam08930 1111678006569 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 1111678006570 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 1111678006571 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1111678006572 Coenzyme A binding pocket [chemical binding]; other site 1111678006573 Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382 1111678006574 TRAM domain; Region: TRAM; pfam01938 1111678006575 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 1111678006576 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1111678006577 S-adenosylmethionine binding site [chemical binding]; other site 1111678006578 Similar to LPXTG-motif cell wall anchor domain protein; predicted non-functional due to frameshift 1111678006579 recombination regulator RecX; Provisional; Region: recX; PRK14135 1111678006580 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1111678006581 GntP family permease; Region: GntP_permease; pfam02447 1111678006582 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 1111678006583 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 1111678006584 N- and C-terminal domain interface [polypeptide binding]; other site 1111678006585 active site 1111678006586 catalytic site [active] 1111678006587 metal binding site [ion binding]; metal-binding site 1111678006588 carbohydrate binding site [chemical binding]; other site 1111678006589 ATP binding site [chemical binding]; other site 1111678006590 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1111678006591 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 1111678006592 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 1111678006593 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1111678006594 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1111678006595 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1111678006596 putative active site [active] 1111678006597 Staphylococcal protein of unknown function (DUF960); Region: DUF960; pfam06124 1111678006598 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1111678006599 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 1111678006600 putative active site [active] 1111678006601 putative metal binding site [ion binding]; other site 1111678006602 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 1111678006603 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1111678006604 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1111678006605 dimer interface [polypeptide binding]; other site 1111678006606 ssDNA binding site [nucleotide binding]; other site 1111678006607 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1111678006608 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1111678006609 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 1111678006610 Amino acid transporters [Amino acid transport and metabolism]; Region: LysP; COG0833 1111678006611 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 1111678006612 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 1111678006613 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1111678006614 Walker A motif; other site 1111678006615 ATP binding site [chemical binding]; other site 1111678006616 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 1111678006617 Walker B motif; other site 1111678006618 arginine finger; other site 1111678006619 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1111678006620 Phosphotransferase enzyme family; Region: APH; pfam01636 1111678006621 substrate binding site [chemical binding]; other site 1111678006622 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 1111678006623 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1111678006624 hypothetical protein; Provisional; Region: PRK07248 1111678006625 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1111678006626 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1111678006627 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1111678006628 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 1111678006629 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1111678006630 DNA binding residues [nucleotide binding] 1111678006631 putative dimer interface [polypeptide binding]; other site 1111678006632 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1111678006633 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1111678006634 active site 1111678006635 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1111678006636 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1111678006637 Walker A motif; other site 1111678006638 ATP binding site [chemical binding]; other site 1111678006639 Walker B motif; other site 1111678006640 arginine finger; other site 1111678006641 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1111678006642 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1111678006643 RuvA N terminal domain; Region: RuvA_N; pfam01330 1111678006644 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 1111678006645 helix-hairpin-helix signature motif; other site 1111678006646 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 1111678006647 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1111678006648 ATP binding site [chemical binding]; other site 1111678006649 Mg2+ binding site [ion binding]; other site 1111678006650 G-X-G motif; other site 1111678006651 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 1111678006652 ATP binding site [chemical binding]; other site 1111678006653 MutL C terminal dimerization domain; Region: MutL_C; pfam08676 1111678006654 Protein of unknown function (DUF805); Region: DUF805; pfam05656 1111678006655 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 1111678006656 MutS domain I; Region: MutS_I; pfam01624 1111678006657 MutS domain II; Region: MutS_II; pfam05188 1111678006658 MutS domain III; Region: MutS_III; pfam05192 1111678006659 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 1111678006660 Walker A/P-loop; other site 1111678006661 ATP binding site [chemical binding]; other site 1111678006662 Q-loop/lid; other site 1111678006663 ABC transporter signature motif; other site 1111678006664 Walker B; other site 1111678006665 D-loop; other site 1111678006666 H-loop/switch region; other site 1111678006667 Predicted membrane protein [Function unknown]; Region: COG4550 1111678006668 Similar to 2-hydroxy-3-oxopropionate reductase; predicted non-functional due to TAA stop codon 1111678006669 Protein of unknown function (DUF1634); Region: DUF1634; cl01741 1111678006670 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1111678006671 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1111678006672 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1111678006673 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1111678006674 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 1111678006675 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1111678006676 active site 1111678006677 motif I; other site 1111678006678 motif II; other site 1111678006679 chaperone protein DnaJ; Provisional; Region: PRK14276 1111678006680 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1111678006681 HSP70 interaction site [polypeptide binding]; other site 1111678006682 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 1111678006683 substrate binding site [polypeptide binding]; other site 1111678006684 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1111678006685 Zn binding sites [ion binding]; other site 1111678006686 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1111678006687 substrate binding site [polypeptide binding]; other site 1111678006688 dimer interface [polypeptide binding]; other site 1111678006689 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4990 1111678006690 aspartate racemase; Region: asp_race; TIGR00035 1111678006691 Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794 1111678006692 Predicted ATP-grasp enzyme [General function prediction only]; Region: COG3919 1111678006693 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 1111678006694 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1111678006695 active site 1111678006696 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 1111678006697 dimer interface [polypeptide binding]; other site 1111678006698 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1111678006699 Ligand Binding Site [chemical binding]; other site 1111678006700 Molecular Tunnel; other site 1111678006701 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 1111678006702 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1111678006703 Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits...; Region: Prefoldin; cl09111 1111678006704 Surface antigen [General function prediction only]; Region: COG3942 1111678006705 CHAP domain; Region: CHAP; pfam05257 1111678006706 rod shape-determining protein MreD; Region: MreD; pfam04093 1111678006707 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreC; COG1792 1111678006708 Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684 1111678006709 nudix motif; other site 1111678006710 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 1111678006711 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1111678006712 active site 1111678006713 dimer interface [polypeptide binding]; other site 1111678006714 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1111678006715 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1111678006716 ligand binding site [chemical binding]; other site 1111678006717 flexible hinge region; other site 1111678006718 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 1111678006719 putative switch regulator; other site 1111678006720 non-specific DNA interactions [nucleotide binding]; other site 1111678006721 DNA binding site [nucleotide binding] 1111678006722 sequence specific DNA binding site [nucleotide binding]; other site 1111678006723 putative cAMP binding site [chemical binding]; other site 1111678006724 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1111678006725 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1111678006726 putative substrate translocation pore; other site 1111678006727 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1111678006728 Ligand Binding Site [chemical binding]; other site 1111678006729 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1111678006730 nucleotide binding site [chemical binding]; other site 1111678006731 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 1111678006732 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3580 1111678006733 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 1111678006734 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1111678006735 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1111678006736 Protoglobin; Region: Protoglobin; pfam11563 1111678006737 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1111678006738 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1111678006739 RNA binding surface [nucleotide binding]; other site 1111678006740 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 1111678006741 active site 1111678006742 uracil binding [chemical binding]; other site 1111678006743 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 1111678006744 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 1111678006745 trmE is a tRNA modification GTPase; Region: trmE; cd04164 1111678006746 G1 box; other site 1111678006747 GTP/Mg2+ binding site [chemical binding]; other site 1111678006748 Switch I region; other site 1111678006749 G2 box; other site 1111678006750 Switch II region; other site 1111678006751 G3 box; other site 1111678006752 G4 box; other site 1111678006753 G5 box; other site 1111678006754 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 1111678006755 H+ Antiporter protein; Region: 2A0121; TIGR00900 1111678006756 Similar to serine/threonine protein kinase; predicted non-functional due to TAG stop codon 1111678006757 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1111678006758 non-specific DNA binding site [nucleotide binding]; other site 1111678006759 salt bridge; other site 1111678006760 sequence-specific DNA binding site [nucleotide binding]; other site 1111678006761 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 1111678006762 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 1111678006763 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1111678006764 generic binding surface II; other site 1111678006765 ssDNA binding site; other site 1111678006766 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1111678006767 ATP binding site [chemical binding]; other site 1111678006768 putative Mg++ binding site [ion binding]; other site 1111678006769 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1111678006770 nucleotide binding region [chemical binding]; other site 1111678006771 ATP-binding site [chemical binding]; other site 1111678006772 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 1111678006773 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 1111678006774 PhnA protein; Region: PhnA; pfam03831 1111678006775 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 1111678006776 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1111678006777 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1111678006778 seryl-tRNA synthetase; Region: serS; TIGR00414 1111678006779 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 1111678006780 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1111678006781 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1111678006782 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1111678006783 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 1111678006784 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1111678006785 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1111678006786 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1111678006787 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1111678006788 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 1111678006789 NAD(P) binding site [chemical binding]; other site 1111678006790 active site 1111678006791 CAAX protease self-immunity; Region: Abi; pfam02517 1111678006792 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1111678006793 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1111678006794 23S rRNA interface [nucleotide binding]; other site 1111678006795 L3 interface [polypeptide binding]; other site 1111678006796 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1111678006797 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1111678006798 FtsX-like permease family; Region: FtsX; pfam02687 1111678006799 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1111678006800 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1111678006801 Walker A/P-loop; other site 1111678006802 ATP binding site [chemical binding]; other site 1111678006803 Q-loop/lid; other site 1111678006804 ABC transporter signature motif; other site 1111678006805 Walker B; other site 1111678006806 D-loop; other site 1111678006807 H-loop/switch region; other site 1111678006808 ribonuclease HIII; Provisional; Region: PRK00996 1111678006809 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 1111678006810 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 1111678006811 RNA/DNA hybrid binding site [nucleotide binding]; other site 1111678006812 active site 1111678006813 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1111678006814 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1111678006815 Catalytic site [active] 1111678006816 pur operon repressor; Provisional; Region: PRK09213 1111678006817 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 1111678006818 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1111678006819 active site 1111678006820 Similar to conserved domain protein; predicted non-functional due to TGA stop codon 1111678006821 elongation factor G; Reviewed; Region: PRK00007 1111678006822 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1111678006823 G1 box; other site 1111678006824 putative GEF interaction site [polypeptide binding]; other site 1111678006825 GTP/Mg2+ binding site [chemical binding]; other site 1111678006826 Switch I region; other site 1111678006827 G2 box; other site 1111678006828 G3 box; other site 1111678006829 Switch II region; other site 1111678006830 G4 box; other site 1111678006831 G5 box; other site 1111678006832 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1111678006833 Elongation Factor G, domain II; Region: EFG_II; pfam14492 1111678006834 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1111678006835 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1111678006836 30S ribosomal protein S7; Validated; Region: PRK05302 1111678006837 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1111678006838 S17 interaction site [polypeptide binding]; other site 1111678006839 S8 interaction site; other site 1111678006840 16S rRNA interaction site [nucleotide binding]; other site 1111678006841 streptomycin interaction site [chemical binding]; other site 1111678006842 23S rRNA interaction site [nucleotide binding]; other site 1111678006843 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1111678006844 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 1111678006845 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl19191 1111678006846 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 1111678006847 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 1111678006848 Sugar transport protein; Region: Sugar_transport; pfam06800 1111678006849 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1111678006850 Putative rRNA methylase; Region: rRNA_methylase; pfam06962 1111678006851 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 1111678006852 Protein involved in initiation of plasmid replication [DNA replication, recombination, and repair]; Region: COG5527 1111678006853 Initiator Replication protein; Region: Rep_3; pfam01051 1111678006854 Lactococcus lactis RepB C-terminus; Region: L_lactis_RepB_C; pfam06430 1111678006855 Protein of unknown function, DUF536; Region: DUF536; pfam04394 1111678006856 Relaxase/Mobilisation nuclease domain; Region: Relaxase; cl19391 1111678006857 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl19151 1111678006858 VanZ like family; Region: VanZ; cl01971 1111678006859 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 1111678006860 Integrase core domain; Region: rve; pfam00665 1111678006861 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1111678006862 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1111678006863 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 1111678006864 metal binding site [ion binding]; metal-binding site 1111678006865 dimer interface [polypeptide binding]; other site 1111678006866 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1111678006867 conserved cys residue [active] 1111678006868 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 1111678006869 putative substrate binding pocket [chemical binding]; other site 1111678006870 AC domain interface; other site 1111678006871 catalytic triad [active] 1111678006872 AB domain interface; other site 1111678006873 interchain disulfide; other site 1111678006874 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1111678006875 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1111678006876 EamA-like transporter family; Region: EamA; pfam00892 1111678006877 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1111678006878 EamA-like transporter family; Region: EamA; pfam00892 1111678006879 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1111678006880 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1111678006881 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 1111678006882 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 1111678006883 Cl binding site [ion binding]; other site 1111678006884 oligomer interface [polypeptide binding]; other site 1111678006885 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 1111678006886 Integrase core domain; Region: rve; pfam00665 1111678006887 Similar to IS30 family transposase; putative non-functional due to transposon insertion 1111678006888 D-lactate dehydrogenase; Provisional; Region: PRK11183 1111678006889 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 1111678006890 HTH-like domain; Region: HTH_21; pfam13276 1111678006891 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 1111678006892 Integrase core domain; Region: rve; pfam00665 1111678006893 Integrase core domain; Region: rve_2; pfam13333 1111678006894 Similar to transposase; predicted non-functional due to TAA stop codon 1111678006895 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK07251 1111678006896 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1111678006897 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1111678006898 Similar to Isochorismatase hydrolase; predicted non-functional due to frameshift 1111678006899 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1111678006900 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1111678006901 Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475 1111678006902 Subtilase family; Region: Peptidase_S8; pfam00082 1111678006903 catalytic triad [active] 1111678006904 putative active site [active] 1111678006905 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238 1111678006906 PA/protease or protease-like domain interface [polypeptide binding]; other site 1111678006907 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 1111678006908 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 1111678006909 peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405 1111678006910 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1111678006911 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 1111678006912 Integrase core domain; Region: rve; pfam00665 1111678006913 PF-ChiA is an uncharacterized chitinase found in the hyperthermophilic archaeon Pyrococcus furiosus with a glycosyl hydrolase family 18 (GH18) catalytic domain as well as a cellulose-binding domain. Members of this domain family are found not only in...; Region: GH18_PF-ChiA-like; cd06543 1111678006914 active site 1111678006915 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 1111678006916 aromatic chitin/cellulose binding site residues [chemical binding]; other site 1111678006917 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 1111678006918 aromatic chitin/cellulose binding site residues [chemical binding]; other site 1111678006919 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 1111678006920 Integrase core domain; Region: rve; pfam00665 1111678006921 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 1111678006922 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1111678006923 putative substrate translocation pore; other site 1111678006924 Initiator Replication protein; Region: Rep_3; pfam01051 1111678006925 alternative sigma factor RpoH; Region: rpoH_proteo; TIGR02392 1111678006926 Low molecular weight phosphatase family; Region: LMWPc; cl00105 1111678006927 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619 1111678006928 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1111678006929 Walker A/P-loop; other site 1111678006930 ATP binding site [chemical binding]; other site 1111678006931 Q-loop/lid; other site 1111678006932 ABC transporter signature motif; other site 1111678006933 Walker B; other site 1111678006934 D-loop; other site 1111678006935 H-loop/switch region; other site 1111678006936 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 1111678006937 Similar to integral membrane protein; predicted non-functional due to TGA stop codon 1111678006938 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1111678006939 active site 1111678006940 DNA binding site [nucleotide binding] 1111678006941 Int/Topo IB signature motif; other site 1111678006942 Protein involved in initiation of plasmid replication [DNA replication, recombination, and repair]; Region: COG5527 1111678006943 Initiator Replication protein; Region: Rep_3; pfam01051 1111678006944 Lactococcus lactis RepB C-terminus; Region: L_lactis_RepB_C; pfam06430 1111678006945 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1111678006946 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 1111678006947 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420