-- dump date 20140619_125434 -- class Genbank::misc_feature -- table misc_feature_note -- id note 272622000001 bacteriocin secretion accessory protein; Region: bacteriocin_acc; TIGR01000 272622000002 HlyD family secretion protein; Region: HlyD_3; pfam13437 272622000003 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418 272622000004 ABC-type bacteriocin transporter; Region: bacteriocin_ABC; TIGR01193 272622000005 putative active site [active] 272622000006 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 272622000007 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272622000008 Walker A/P-loop; other site 272622000009 ATP binding site [chemical binding]; other site 272622000010 Q-loop/lid; other site 272622000011 ABC transporter signature motif; other site 272622000012 Walker B; other site 272622000013 D-loop; other site 272622000014 H-loop/switch region; other site 272622000015 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 272622000016 Integrase core domain; Region: rve; pfam00665 272622000017 HTH domain; Region: HTH_11; cl17392 272622000018 Protein involved in initiation of plasmid replication [DNA replication, recombination, and repair]; Region: COG5527 272622000019 Initiator Replication protein; Region: Rep_3; pfam01051 272622000020 Lactococcus lactis RepB C-terminus; Region: L_lactis_RepB_C; pfam06430 272622000021 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 272622000022 Integrase core domain; Region: rve; pfam00665 272622000023 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 272622000024 IHF dimer interface [polypeptide binding]; other site 272622000025 IHF - DNA interface [nucleotide binding]; other site 272622000026 Initiator Replication protein; Region: Rep_3; pfam01051 272622000027 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 272622000028 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 272622000029 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 272622000030 active site 272622000031 metal binding site [ion binding]; metal-binding site 272622000032 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 272622000033 Transposase; Region: HTH_Tnp_1; pfam01527 272622000034 LytTr DNA-binding domain; Region: LytTR; pfam04397 272622000035 Protein involved in initiation of plasmid replication [DNA replication, recombination, and repair]; Region: COG5527 272622000036 Initiator Replication protein; Region: Rep_3; pfam01051 272622000037 Lactococcus lactis RepB C-terminus; Region: L_lactis_RepB_C; pfam06430 272622000038 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 272622000039 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 272622000040 Multicopper oxidase; Region: Cu-oxidase; pfam00394 272622000041 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 272622000042 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 272622000043 Integrase core domain; Region: rve; pfam00665 272622000044 Integrase core domain; Region: rve_3; pfam13683 272622000045 Transposase; Region: HTH_Tnp_1; pfam01527 272622000046 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 272622000047 Domain of unknown function (DUF3883); Region: DUF3883; pfam13020 272622000048 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 272622000049 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 272622000050 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 272622000051 Glutamine amidotransferase class-I; Region: GATase; pfam00117 272622000052 glutamine binding [chemical binding]; other site 272622000053 catalytic triad [active] 272622000054 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 272622000055 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 272622000056 aminodeoxychorismate synthase, component I, bacterial clade; Region: pabB; TIGR00553 272622000057 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 272622000058 substrate-cofactor binding pocket; other site 272622000059 homodimer interface [polypeptide binding]; other site 272622000060 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 272622000061 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272622000062 catalytic residue [active] 272622000063 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272622000064 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 272622000065 Coenzyme A binding pocket [chemical binding]; other site 272622000066 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 272622000067 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 272622000068 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272622000069 putative substrate translocation pore; other site 272622000070 VanZ like family; Region: VanZ; pfam04892 272622000071 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 272622000072 Integrase core domain; Region: rve; pfam00665 272622000073 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 272622000074 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 272622000075 WxL domain surface cell wall-binding; Region: WxL; pfam13731 272622000076 Protein involved in initiation of plasmid replication [DNA replication, recombination, and repair]; Region: COG5527 272622000077 Initiator Replication protein; Region: Rep_3; pfam01051 272622000078 Lactococcus lactis RepB C-terminus; Region: L_lactis_RepB_C; pfam06430 272622000079 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 272622000080 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 272622000081 putative active site [active] 272622000082 putative NTP binding site [chemical binding]; other site 272622000083 putative nucleic acid binding site [nucleotide binding]; other site 272622000084 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 272622000085 Type II intron maturase; Region: Intron_maturas2; pfam01348 272622000086 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 272622000087 Bacterial mobilisation protein (MobC); Region: MobC; pfam05713 272622000088 Domain of unknown function (DUF1919); Region: DUF1919; pfam08942 272622000089 Domain of unknown function (DUF4298); Region: DUF4298; pfam14131 272622000090 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 272622000091 putative substrate binding pocket [chemical binding]; other site 272622000092 AC domain interface; other site 272622000093 catalytic triad [active] 272622000094 AB domain interface; other site 272622000095 interchain disulfide; other site 272622000096 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 272622000097 Domain of unknown function (DUF1413); Region: DUF1413; pfam07205 272622000098 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 272622000099 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 272622000100 Cl binding site [ion binding]; other site 272622000101 oligomer interface [polypeptide binding]; other site 272622000102 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 272622000103 Integrase core domain; Region: rve; pfam00665 272622000104 D-lactate dehydrogenase; Provisional; Region: PRK11183 272622000105 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 272622000106 putative transposase OrfB; Reviewed; Region: PHA02517 272622000107 HTH-like domain; Region: HTH_21; pfam13276 272622000108 Integrase core domain; Region: rve; pfam00665 272622000109 Integrase core domain; Region: rve_2; pfam13333 272622000110 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK07251 272622000111 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 272622000112 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 272622000113 Isochorismatase family; Region: Isochorismatase; pfam00857 272622000114 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 272622000115 catalytic triad [active] 272622000116 conserved cis-peptide bond; other site 272622000117 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 272622000118 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 272622000119 COMC family; Region: ComC; pfam03047 272622000120 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 272622000121 Integrase core domain; Region: rve; pfam00665 272622000122 Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475 272622000123 putative active site [active] 272622000124 catalytic triad [active] 272622000125 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238 272622000126 PA/protease or protease-like domain interface [polypeptide binding]; other site 272622000127 Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475 272622000128 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 272622000129 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 272622000130 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 272622000131 peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405 272622000132 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 272622000133 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 272622000134 Integrase core domain; Region: rve; pfam00665 272622000135 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 272622000136 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 272622000137 DNA polymerase III subunit epsilon; Validated; Region: PRK06195 272622000138 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 272622000139 DNA-binding site [nucleotide binding]; DNA binding site 272622000140 RNA-binding motif; other site 272622000141 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 272622000142 DNA-binding site [nucleotide binding]; DNA binding site 272622000143 RNA-binding motif; other site 272622000144 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 272622000145 Integrase core domain; Region: rve; pfam00665 272622000146 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 272622000147 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 272622000148 P-loop; other site 272622000149 Magnesium ion binding site [ion binding]; other site 272622000150 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 272622000151 Magnesium ion binding site [ion binding]; other site 272622000152 Omega Transcriptional Repressor; Region: Omega_Repress; pfam07764 272622000153 Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970 272622000154 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 272622000155 Transposase; Region: HTH_Tnp_1; pfam01527 272622000156 HTH-like domain; Region: HTH_21; pfam13276 272622000157 DDE domain; Region: DDE_Tnp_IS240; pfam13610 272622000158 Integrase core domain; Region: rve; pfam00665 272622000159 Integrase core domain; Region: rve_2; pfam13333 272622000160 HTH-like domain; Region: HTH_21; pfam13276 272622000161 Integrase core domain; Region: rve; pfam00665 272622000162 Integrase core domain; Region: rve_3; pfam13683 272622000163 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 272622000164 Transposase; Region: HTH_Tnp_1; pfam01527 272622000165 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 272622000166 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272622000167 active site 272622000168 phosphorylation site [posttranslational modification] 272622000169 intermolecular recognition site; other site 272622000170 dimerization interface [polypeptide binding]; other site 272622000171 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272622000172 DNA binding site [nucleotide binding] 272622000173 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272622000174 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 272622000175 dimerization interface [polypeptide binding]; other site 272622000176 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272622000177 dimer interface [polypeptide binding]; other site 272622000178 phosphorylation site [posttranslational modification] 272622000179 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272622000180 ATP binding site [chemical binding]; other site 272622000181 Mg2+ binding site [ion binding]; other site 272622000182 G-X-G motif; other site 272622000183 Prolipoprotein diacylglyceryl transferase; Region: LGT; pfam01790 272622000184 Protein of unknown function (DUF2933); Region: DUF2933; pfam11666 272622000185 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 272622000186 Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; Region: SPEC; cl02488 272622000187 linker region; other site 272622000188 Surface antigen [General function prediction only]; Region: COG3942 272622000189 CHAP domain; Region: CHAP; pfam05257 272622000190 phosphotransferase system, lactose specific, IIC component; Region: lac_pts_IIC; TIGR00394 272622000191 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 272622000192 PTS_IIB_lactose: subunit IIB of enzyme II (EII) of the lactose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS) found in Firmicutes as well as Actinobacteria. In this system, EII is a lactose-specific permease with two...; Region: PTS_IIB_lactose; cd05565 272622000193 active site 272622000194 P-loop; other site 272622000195 phosphorylation site [posttranslational modification] 272622000196 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 272622000197 methionine cluster; other site 272622000198 active site 272622000199 phosphorylation site [posttranslational modification] 272622000200 metal binding site [ion binding]; metal-binding site 272622000201 tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK12399 272622000202 tagatose-6-phosphate kinase; Region: lacC; TIGR01231 272622000203 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 272622000204 putative substrate binding site [chemical binding]; other site 272622000205 putative ATP binding site [chemical binding]; other site 272622000206 galactose-6-phosphate isomerase subunit LacB; Reviewed; Region: PRK08622 272622000207 galactose-6-phosphate isomerase subunit LacA; Reviewed; Region: PRK08621 272622000208 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 272622000209 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 272622000210 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 272622000211 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 272622000212 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 272622000213 catalytic residues [active] 272622000214 catalytic nucleophile [active] 272622000215 Presynaptic Site I dimer interface [polypeptide binding]; other site 272622000216 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 272622000217 Synaptic Flat tetramer interface [polypeptide binding]; other site 272622000218 Synaptic Site I dimer interface [polypeptide binding]; other site 272622000219 DNA binding site [nucleotide binding] 272622000220 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 272622000221 DNA-binding interface [nucleotide binding]; DNA binding site 272622000222 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 272622000223 Transposase; Region: HTH_Tnp_1; pfam01527 272622000224 Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164 272622000225 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 272622000226 active site 272622000227 Zn binding site [ion binding]; other site 272622000228 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 272622000229 Integrase core domain; Region: rve; pfam00665 272622000230 carbon starvation protein A; Provisional; Region: PRK15015 272622000231 Carbon starvation protein CstA; Region: CstA; pfam02554 272622000232 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 272622000233 multiple promoter invertase; Provisional; Region: mpi; PRK13413 272622000234 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 272622000235 catalytic residues [active] 272622000236 catalytic nucleophile [active] 272622000237 Presynaptic Site I dimer interface [polypeptide binding]; other site 272622000238 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 272622000239 Synaptic Flat tetramer interface [polypeptide binding]; other site 272622000240 Synaptic Site I dimer interface [polypeptide binding]; other site 272622000241 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 272622000242 DNA-binding interface [nucleotide binding]; DNA binding site 272622000243 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 272622000244 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 272622000245 active site 272622000246 Zn binding site [ion binding]; other site 272622000247 The substrate binding component of an ABC-type lactococcal OppA-like transport system contains; Region: PBP2_Lactococcal_OppA_like; cd08510 272622000248 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 272622000249 peptide binding site [polypeptide binding]; other site 272622000250 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 272622000251 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 272622000252 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272622000253 dimer interface [polypeptide binding]; other site 272622000254 conserved gate region; other site 272622000255 putative PBP binding loops; other site 272622000256 ABC-ATPase subunit interface; other site 272622000257 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 272622000258 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272622000259 dimer interface [polypeptide binding]; other site 272622000260 conserved gate region; other site 272622000261 putative PBP binding loops; other site 272622000262 ABC-ATPase subunit interface; other site 272622000263 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 272622000264 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 272622000265 Walker A/P-loop; other site 272622000266 ATP binding site [chemical binding]; other site 272622000267 Q-loop/lid; other site 272622000268 ABC transporter signature motif; other site 272622000269 Walker B; other site 272622000270 D-loop; other site 272622000271 H-loop/switch region; other site 272622000272 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 272622000273 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 272622000274 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 272622000275 Walker A/P-loop; other site 272622000276 ATP binding site [chemical binding]; other site 272622000277 Q-loop/lid; other site 272622000278 ABC transporter signature motif; other site 272622000279 Walker B; other site 272622000280 D-loop; other site 272622000281 H-loop/switch region; other site 272622000282 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 272622000283 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 272622000284 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 272622000285 Protein involved in initiation of plasmid replication [DNA replication, recombination, and repair]; Region: COG5527 272622000286 Initiator Replication protein; Region: Rep_3; pfam01051 272622000287 Lactococcus lactis RepB C-terminus; Region: L_lactis_RepB_C; pfam06430 272622000288 AAA domain; Region: AAA_31; pfam13614 272622000289 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 272622000290 P-loop; other site 272622000291 Magnesium ion binding site [ion binding]; other site 272622000292 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 272622000293 Magnesium ion binding site [ion binding]; other site 272622000294 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 272622000295 MobA/MobL family; Region: MobA_MobL; pfam03389 272622000296 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 272622000297 Integrase core domain; Region: rve; pfam00665 272622000298 manganese transport protein MntH; Reviewed; Region: PRK00701 272622000299 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 272622000300 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 272622000301 Ligand Binding Site [chemical binding]; other site 272622000302 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 272622000303 Integrase core domain; Region: rve; pfam00665 272622000304 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; pfam02522 272622000305 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 272622000306 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 272622000307 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 272622000308 C4-dicarboxylate transporters of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_C4-dicarb_trans; cd09325 272622000309 gating phenylalanine in ion channel; other site 272622000310 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 272622000311 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 272622000312 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 272622000313 active site 272622000314 catalytic residues [active] 272622000315 6-phospho-beta-galactosidase; Provisional; Region: PRK13511 272622000316 beta-galactosidase; Region: BGL; TIGR03356 272622000317 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 272622000318 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 272622000319 DNA-binding transcriptional activator EvgA; Provisional; Region: PRK09958 272622000320 Predicted helicase [General function prediction only]; Region: COG4889 272622000321 Restriction endonuclease; Region: Mrr_cat_2; pfam13156 272622000322 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272622000323 ATP binding site [chemical binding]; other site 272622000324 putative Mg++ binding site [ion binding]; other site 272622000325 nucleotide binding region [chemical binding]; other site 272622000326 Helicase conserved C-terminal domain; Region: Helicase_C; pfam00271 272622000327 ATP-binding site [chemical binding]; other site 272622000328 MerR family regulatory protein; Region: MerR; pfam00376 272622000329 Protein involved in initiation of plasmid replication [DNA replication, recombination, and repair]; Region: COG5527 272622000330 Initiator Replication protein; Region: Rep_3; pfam01051 272622000331 Lactococcus lactis RepB C-terminus; Region: L_lactis_RepB_C; pfam06430 272622000332 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 272622000333 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272622000334 Walker A motif; other site 272622000335 ATP binding site [chemical binding]; other site 272622000336 Walker B motif; other site 272622000337 arginine finger; other site 272622000338 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 272622000339 DnaA box-binding interface [nucleotide binding]; other site 272622000340 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 272622000341 DNA polymerase III beta subunit; Region: POL3Bc; smart00480 272622000342 putative DNA binding surface [nucleotide binding]; other site 272622000343 dimer interface [polypeptide binding]; other site 272622000344 beta-clamp/clamp loader binding surface; other site 272622000345 beta-clamp/translesion DNA polymerase binding surface; other site 272622000346 ATP-dependent nuclease, subunit B [DNA replication, recombination, and repair]; Region: AddB; COG3857 272622000347 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 272622000348 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 272622000349 Part of AAA domain; Region: AAA_19; pfam13245 272622000350 Family description; Region: UvrD_C_2; pfam13538 272622000351 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 272622000352 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 272622000353 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272622000354 non-specific DNA binding site [nucleotide binding]; other site 272622000355 salt bridge; other site 272622000356 sequence-specific DNA binding site [nucleotide binding]; other site 272622000357 GTP-binding protein YchF; Reviewed; Region: PRK09601 272622000358 YchF GTPase; Region: YchF; cd01900 272622000359 G1 box; other site 272622000360 GTP/Mg2+ binding site [chemical binding]; other site 272622000361 Switch I region; other site 272622000362 G2 box; other site 272622000363 Switch II region; other site 272622000364 G3 box; other site 272622000365 G4 box; other site 272622000366 G5 box; other site 272622000367 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 272622000368 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272622000369 non-specific DNA binding site [nucleotide binding]; other site 272622000370 salt bridge; other site 272622000371 sequence-specific DNA binding site [nucleotide binding]; other site 272622000372 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 272622000373 putative active site [active] 272622000374 catalytic residue [active] 272622000375 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 272622000376 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 272622000377 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272622000378 ATP binding site [chemical binding]; other site 272622000379 putative Mg++ binding site [ion binding]; other site 272622000380 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272622000381 nucleotide binding region [chemical binding]; other site 272622000382 ATP-binding site [chemical binding]; other site 272622000383 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 272622000384 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 272622000385 RNA binding surface [nucleotide binding]; other site 272622000386 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 272622000387 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 272622000388 RNA binding site [nucleotide binding]; other site 272622000389 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 272622000390 SH3-like domain; Region: SH3_8; pfam13457 272622000391 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 272622000392 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 272622000393 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 272622000394 Ligand Binding Site [chemical binding]; other site 272622000395 TilS substrate C-terminal domain; Region: TilS_C; smart00977 272622000396 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 272622000397 active site 272622000398 ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465 272622000399 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272622000400 Walker A motif; other site 272622000401 ATP binding site [chemical binding]; other site 272622000402 Walker B motif; other site 272622000403 arginine finger; other site 272622000404 Peptidase family M41; Region: Peptidase_M41; pfam01434 272622000405 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 272622000406 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 272622000407 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 272622000408 active site 272622000409 P-loop; other site 272622000410 phosphorylation site [posttranslational modification] 272622000411 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 272622000412 active site 272622000413 P-loop; other site 272622000414 phosphorylation site [posttranslational modification] 272622000415 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 272622000416 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 272622000417 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 272622000418 active site 272622000419 P-loop; other site 272622000420 phosphorylation site [posttranslational modification] 272622000421 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 272622000422 active site 272622000423 phosphorylation site [posttranslational modification] 272622000424 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 272622000425 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 272622000426 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 272622000427 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 272622000428 PGAP1-like protein; Region: PGAP1; pfam07819 272622000429 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 272622000430 putative transposase OrfB; Reviewed; Region: PHA02517 272622000431 HTH-like domain; Region: HTH_21; pfam13276 272622000432 Integrase core domain; Region: rve; pfam00665 272622000433 Integrase core domain; Region: rve_3; pfam13683 272622000434 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 272622000435 Transposase; Region: HTH_Tnp_1; pfam01527 272622000436 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 272622000437 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272622000438 Coenzyme A binding pocket [chemical binding]; other site 272622000439 Predicted membrane protein [Function unknown]; Region: XynA; COG2314 272622000440 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 272622000441 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 272622000442 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 272622000443 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 272622000444 Sulfate transporter family; Region: Sulfate_transp; pfam00916 272622000445 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272622000446 Coenzyme A binding pocket [chemical binding]; other site 272622000447 aromatic amino acid aminotransferase; Validated; Region: PRK07309 272622000448 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 272622000449 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272622000450 homodimer interface [polypeptide binding]; other site 272622000451 catalytic residue [active] 272622000452 Recombination protein O N terminal; Region: RecO_N; pfam11967 272622000453 Recombinational DNA repair protein (RecF pathway) [DNA replication, recombination, and repair]; Region: RecO; COG1381 272622000454 Recombination protein O C terminal; Region: RecO_C; pfam02565 272622000455 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 272622000456 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 272622000457 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 272622000458 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 272622000459 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 272622000460 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 272622000461 E3 interaction surface; other site 272622000462 lipoyl attachment site [posttranslational modification]; other site 272622000463 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 272622000464 E3 interaction surface; other site 272622000465 lipoyl attachment site [posttranslational modification]; other site 272622000466 e3 binding domain; Region: E3_binding; pfam02817 272622000467 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 272622000468 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 272622000469 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 272622000470 TPP binding site [chemical binding]; other site 272622000471 alpha subunit interface [polypeptide binding]; other site 272622000472 heterodimer interface [polypeptide binding]; other site 272622000473 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 272622000474 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 272622000475 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 272622000476 tetramer interface [polypeptide binding]; other site 272622000477 TPP-binding site [chemical binding]; other site 272622000478 heterodimer interface [polypeptide binding]; other site 272622000479 phosphorylation loop region [posttranslational modification] 272622000480 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 272622000481 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 272622000482 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 272622000483 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 272622000484 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 272622000485 active site 272622000486 catalytic site [active] 272622000487 metal binding site [ion binding]; metal-binding site 272622000488 dimer interface [polypeptide binding]; other site 272622000489 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 272622000490 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 272622000491 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 272622000492 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 272622000493 active site 272622000494 HIGH motif; other site 272622000495 dimer interface [polypeptide binding]; other site 272622000496 KMSKS motif; other site 272622000497 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 272622000498 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 272622000499 putative phosphate acyltransferase; Provisional; Region: PRK05331 272622000500 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 272622000501 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 272622000502 active site 272622000503 motif I; other site 272622000504 motif II; other site 272622000505 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 272622000506 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 272622000507 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 272622000508 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 272622000509 ABC transporter; Region: ABC_tran_2; pfam12848 272622000510 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 272622000511 yiaA/B two helix domain; Region: YiaAB; pfam05360 272622000512 short chain dehydrogenase; Validated; Region: PRK06182 272622000513 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 272622000514 NADP binding site [chemical binding]; other site 272622000515 active site 272622000516 steroid binding site; other site 272622000517 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 272622000518 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 272622000519 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 272622000520 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 272622000521 homodimer interface [polypeptide binding]; other site 272622000522 substrate-cofactor binding pocket; other site 272622000523 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272622000524 catalytic residue [active] 272622000525 short chain dehydrogenase; Validated; Region: PRK06182 272622000526 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 272622000527 NADP binding site [chemical binding]; other site 272622000528 active site 272622000529 steroid binding site; other site 272622000530 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 272622000531 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 272622000532 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 272622000533 Ligand Binding Site [chemical binding]; other site 272622000534 Predicted esterase [General function prediction only]; Region: COG0400 272622000535 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 272622000536 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 272622000537 Zn binding site [ion binding]; other site 272622000538 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 272622000539 Zn binding site [ion binding]; other site 272622000540 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 272622000541 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 272622000542 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 272622000543 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 272622000544 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 272622000545 Soluble P-type ATPase [General function prediction only]; Region: COG4087 272622000546 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4705 272622000547 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 272622000548 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 272622000549 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 272622000550 ParB-like nuclease domain; Region: ParBc; pfam02195 272622000551 KorB domain; Region: KorB; pfam08535 272622000552 ATPase related to the helicase subunit of the Holliday junction resolvase [DNA replication, recombination, and repair]; Region: MGS1; COG2256 272622000553 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272622000554 Walker A motif; other site 272622000555 ATP binding site [chemical binding]; other site 272622000556 Walker B motif; other site 272622000557 arginine finger; other site 272622000558 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 272622000559 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 272622000560 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272622000561 Coenzyme A binding pocket [chemical binding]; other site 272622000562 Protein of unknown function (DUF3013); Region: DUF3013; pfam11217 272622000563 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 272622000564 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272622000565 Walker A/P-loop; other site 272622000566 ATP binding site [chemical binding]; other site 272622000567 Q-loop/lid; other site 272622000568 ABC transporter signature motif; other site 272622000569 Walker B; other site 272622000570 D-loop; other site 272622000571 H-loop/switch region; other site 272622000572 ABC transporter; Region: ABC_tran_2; pfam12848 272622000573 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 272622000574 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 272622000575 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272622000576 S-adenosylmethionine binding site [chemical binding]; other site 272622000577 Domain of unknown function (DUF1905); Region: DUF1905; pfam08922 272622000578 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 272622000579 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 272622000580 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272622000581 S-adenosylmethionine binding site [chemical binding]; other site 272622000582 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 272622000583 RNA methyltransferase, RsmE family; Region: TIGR00046 272622000584 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 272622000585 putative active site [active] 272622000586 putative metal binding site [ion binding]; other site 272622000587 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 272622000588 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 272622000589 Zn2+ binding site [ion binding]; other site 272622000590 Mg2+ binding site [ion binding]; other site 272622000591 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 272622000592 synthetase active site [active] 272622000593 NTP binding site [chemical binding]; other site 272622000594 metal binding site [ion binding]; metal-binding site 272622000595 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 272622000596 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 272622000597 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 272622000598 putative active site [active] 272622000599 dimerization interface [polypeptide binding]; other site 272622000600 putative tRNAtyr binding site [nucleotide binding]; other site 272622000601 Predicted integral membrane protein [Function unknown]; Region: COG3548 272622000602 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 272622000603 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272622000604 amino acid transporter; Region: 2A0306; TIGR00909 272622000605 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 272622000606 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 272622000607 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 272622000608 putative acyl-acceptor binding pocket; other site 272622000609 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 272622000610 MarR family; Region: MarR_2; pfam12802 272622000611 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 272622000612 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 272622000613 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272622000614 nucleotide binding region [chemical binding]; other site 272622000615 ATP-binding site [chemical binding]; other site 272622000616 SEC-C motif; Region: SEC-C; pfam02810 272622000617 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroG; COG0722 272622000618 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 272622000619 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 272622000620 dimerization domain swap beta strand [polypeptide binding]; other site 272622000621 regulatory protein interface [polypeptide binding]; other site 272622000622 active site 272622000623 regulatory phosphorylation site [posttranslational modification]; other site 272622000624 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 272622000625 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 272622000626 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 272622000627 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 272622000628 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG0718 272622000629 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 272622000630 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 272622000631 Malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate cycle, which allows certain organisms, like plants and fungi, to derive their...; Region: malate_synt; cl17217 272622000632 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 272622000633 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272622000634 Major Facilitator Superfamily; Region: MFS_1; pfam07690 272622000635 putative substrate translocation pore; other site 272622000636 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 272622000637 Transposase; Region: HTH_Tnp_1; pfam01527 272622000638 putative transposase OrfB; Reviewed; Region: PHA02517 272622000639 HTH-like domain; Region: HTH_21; pfam13276 272622000640 Integrase core domain; Region: rve; pfam00665 272622000641 Integrase core domain; Region: rve_3; pfam13683 272622000642 Transposase, Mutator family; Region: Transposase_mut; pfam00872 272622000643 MULE transposase domain; Region: MULE; pfam10551 272622000644 putative transposase OrfB; Reviewed; Region: PHA02517 272622000645 HTH-like domain; Region: HTH_21; pfam13276 272622000646 Integrase core domain; Region: rve; pfam00665 272622000647 Integrase core domain; Region: rve_3; pfam13683 272622000648 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 272622000649 Transposase; Region: HTH_Tnp_1; pfam01527 272622000650 argininosuccinate synthase; Provisional; Region: PRK13820 272622000651 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 272622000652 ANP binding site [chemical binding]; other site 272622000653 Substrate Binding Site II [chemical binding]; other site 272622000654 Substrate Binding Site I [chemical binding]; other site 272622000655 argininosuccinate lyase; Provisional; Region: PRK00855 272622000656 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 272622000657 active sites [active] 272622000658 tetramer interface [polypeptide binding]; other site 272622000659 drug efflux system protein MdtG; Provisional; Region: PRK09874 272622000660 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272622000661 putative substrate translocation pore; other site 272622000662 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 272622000663 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 272622000664 WHG domain; Region: WHG; pfam13305 272622000665 ribonuclease P; Reviewed; Region: rnpA; PRK00499 272622000666 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 272622000667 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 272622000668 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 272622000669 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 272622000670 G-X-X-G motif; other site 272622000671 R3H domain. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. R3H domains are found in proteins together with ATPase domains, SF1 helicase domains, SF2 DEAH helicase domains, Cys-rich...; Region: R3H; cl00297 272622000672 RxxxH motif; other site 272622000673 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 272622000674 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 272622000675 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 272622000676 active site 272622000677 catalytic tetrad [active] 272622000678 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 272622000679 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272622000680 non-specific DNA binding site [nucleotide binding]; other site 272622000681 salt bridge; other site 272622000682 sequence-specific DNA binding site [nucleotide binding]; other site 272622000683 COMC family; Region: ComC; pfam03047 272622000684 CAAX protease self-immunity; Region: Abi; pfam02517 272622000685 hypothetical protein; Provisional; Region: PRK05473 272622000686 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 272622000687 hypothetical protein; Provisional; Region: PRK13678 272622000688 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 272622000689 putative NAD(P)-binding oxidoreductase; Provisional; Region: PRK09730 272622000690 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272622000691 NAD(P) binding site [chemical binding]; other site 272622000692 active site 272622000693 Uncharacterized protein conserved in bacteria (DUF2316); Region: DUF2316; pfam10078 272622000694 Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967 272622000695 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272622000696 NAD(P) binding site [chemical binding]; other site 272622000697 active site 272622000698 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 272622000699 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 272622000700 putative DNA binding site [nucleotide binding]; other site 272622000701 putative Zn2+ binding site [ion binding]; other site 272622000702 glycogen branching enzyme; Provisional; Region: PRK12313 272622000703 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 272622000704 Alpha amylase catalytic domain found in bacterial and eukaryotic branching enzymes; Region: AmyAc_bac_euk_BE; cd11321 272622000705 active site 272622000706 catalytic site [active] 272622000707 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 272622000708 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 272622000709 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 272622000710 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 272622000711 Collagen binding domain; Region: Collagen_bind; pfam05737 272622000712 Collagen binding domain; Region: Collagen_bind; pfam05737 272622000713 Collagen binding domain; Region: Collagen_bind; pfam05737 272622000714 Cna protein B-type domain; Region: Cna_B; pfam05738 272622000715 Cna protein B-type domain; Region: Cna_B; pfam05738 272622000716 Cna protein B-type domain; Region: Cna_B; pfam05738 272622000717 Cna protein B-type domain; Region: Cna_B; pfam05738 272622000718 Cna protein B-type domain; Region: Cna_B; pfam05738 272622000719 Cna protein B-type domain; Region: Cna_B; pfam05738 272622000720 Cna protein B-type domain; Region: Cna_B; pfam05738 272622000721 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 272622000722 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 272622000723 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 272622000724 WxL domain surface cell wall-binding; Region: WxL; pfam13731 272622000725 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 272622000726 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272622000727 non-specific DNA binding site [nucleotide binding]; other site 272622000728 salt bridge; other site 272622000729 sequence-specific DNA binding site [nucleotide binding]; other site 272622000730 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 272622000731 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 272622000732 Protein of unknown function (DUF975); Region: DUF975; cl10504 272622000733 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272622000734 Major Facilitator Superfamily; Region: MFS_1; pfam07690 272622000735 putative substrate translocation pore; other site 272622000736 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 272622000737 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 272622000738 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; cl17626 272622000739 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 272622000740 aminotransferase AlaT; Validated; Region: PRK09265 272622000741 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 272622000742 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272622000743 homodimer interface [polypeptide binding]; other site 272622000744 catalytic residue [active] 272622000745 Pleiotropic transcriptional repressor [Transcription]; Region: CodY; COG4465 272622000746 CodY GAF-like domain; Region: CodY; pfam06018 272622000747 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 272622000748 Asp-tRNAAsn/Glu-tRNAGln amidotransferase C subunit [Translation, ribosomal structure and biogenesis]; Region: GatC; COG0721 272622000749 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 272622000750 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 272622000751 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 272622000752 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 272622000753 GatB domain; Region: GatB_Yqey; pfam02637 272622000754 amidase; Provisional; Region: PRK06529 272622000755 Amidase; Region: Amidase; cl11426 272622000756 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 272622000757 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 272622000758 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 272622000759 DNA-binding site [nucleotide binding]; DNA binding site 272622000760 RNA-binding motif; other site 272622000761 Rhomboid family; Region: Rhomboid; pfam01694 272622000762 Domain of unknown function (DUF3284); Region: DUF3284; pfam11687 272622000763 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 272622000764 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 272622000765 active site 272622000766 metal binding site [ion binding]; metal-binding site 272622000767 Predicted acetyltransferase involved in intracellular survival and related acetyltransferases [General function prediction only]; Region: Eis; COG4552 272622000768 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 272622000769 Uncharacterized conserved protein [Function unknown]; Region: COG3589 272622000770 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 272622000771 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 272622000772 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 272622000773 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 272622000774 beta-galactosidase; Region: BGL; TIGR03356 272622000775 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 272622000776 trimer interface [polypeptide binding]; other site 272622000777 active site 272622000778 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 272622000779 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 272622000780 active site 272622000781 metal binding site [ion binding]; metal-binding site 272622000782 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 272622000783 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4470 272622000784 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 272622000785 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272622000786 FeS/SAM binding site; other site 272622000787 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 272622000788 dimer interface [polypeptide binding]; other site 272622000789 FMN binding site [chemical binding]; other site 272622000790 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 272622000791 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 272622000792 substrate binding pocket [chemical binding]; other site 272622000793 chain length determination region; other site 272622000794 substrate-Mg2+ binding site; other site 272622000795 catalytic residues [active] 272622000796 aspartate-rich region 1; other site 272622000797 active site lid residues [active] 272622000798 aspartate-rich region 2; other site 272622000799 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 272622000800 UbiA prenyltransferase family; Region: UbiA; pfam01040 272622000801 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 272622000802 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 272622000803 G1 box; other site 272622000804 GTP/Mg2+ binding site [chemical binding]; other site 272622000805 Switch I region; other site 272622000806 G2 box; other site 272622000807 G3 box; other site 272622000808 Switch II region; other site 272622000809 G4 box; other site 272622000810 G5 box; other site 272622000811 Nucleoside recognition; Region: Gate; pfam07670 272622000812 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 272622000813 Nucleoside recognition; Region: Gate; pfam07670 272622000814 FeoA domain; Region: FeoA; pfam04023 272622000815 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 272622000816 methionine sulfoxide reductase B; Provisional; Region: PRK00222 272622000817 SelR domain; Region: SelR; pfam01641 272622000818 Predicted kinase related to dihydroxyacetone kinase [General function prediction only]; Region: COG1461 272622000819 DAK2 domain; Region: Dak2; pfam02734 272622000820 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 272622000821 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 272622000822 Uncharacterized membrane-bound protein conserved in bacteria [Function unknown]; Region: COG4858 272622000823 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 272622000824 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 272622000825 substrate binding site; other site 272622000826 tetramer interface; other site 272622000827 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 272622000828 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 272622000829 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 272622000830 NAD binding site [chemical binding]; other site 272622000831 substrate binding site [chemical binding]; other site 272622000832 homodimer interface [polypeptide binding]; other site 272622000833 active site 272622000834 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 272622000835 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 272622000836 NADP binding site [chemical binding]; other site 272622000837 active site 272622000838 putative substrate binding site [chemical binding]; other site 272622000839 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 272622000840 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_6; cd04955 272622000841 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 272622000842 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196 272622000843 Probable Catalytic site; other site 272622000844 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 272622000845 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 272622000846 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 272622000847 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 272622000848 Walker A/P-loop; other site 272622000849 ATP binding site [chemical binding]; other site 272622000850 Q-loop/lid; other site 272622000851 ABC transporter signature motif; other site 272622000852 Walker B; other site 272622000853 D-loop; other site 272622000854 H-loop/switch region; other site 272622000855 Predicted membrane protein (DUF2142); Region: DUF2142; pfam09913 272622000856 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 272622000857 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 272622000858 active site 272622000859 Rhamnan synthesis protein F; Region: RgpF; pfam05045 272622000860 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 272622000861 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 272622000862 Ligand binding site; other site 272622000863 Putative Catalytic site; other site 272622000864 DXD motif; other site 272622000865 Uncharacterized conserved protein (DUF2304); Region: DUF2304; cl01034 272622000866 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 272622000867 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 272622000868 Protein of unknown function (DUF3184); Region: DUF3184; pfam11380 272622000869 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 272622000870 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 272622000871 putative ADP-binding pocket [chemical binding]; other site 272622000872 beta-1,6-galactofuranosyltransferase; Provisional; Region: PRK09814 272622000873 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 272622000874 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 272622000875 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 272622000876 UDP-galactopyranose mutase; Region: GLF; pfam03275 272622000877 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 272622000878 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 272622000879 Predicted membrane protein (DUF2142); Region: DUF2142; pfam09913 272622000880 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 272622000881 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 272622000882 active site 272622000883 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 272622000884 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 272622000885 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 272622000886 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 272622000887 active site 272622000888 GTPase YqeH; Provisional; Region: PRK13796 272622000889 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 272622000890 GTP/Mg2+ binding site [chemical binding]; other site 272622000891 G4 box; other site 272622000892 G5 box; other site 272622000893 G1 box; other site 272622000894 Switch I region; other site 272622000895 G2 box; other site 272622000896 G3 box; other site 272622000897 Switch II region; other site 272622000898 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688 272622000899 nudix motif; other site 272622000900 GTPases [General function prediction only]; Region: HflX; COG2262 272622000901 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 272622000902 HflX GTPase family; Region: HflX; cd01878 272622000903 G1 box; other site 272622000904 GTP/Mg2+ binding site [chemical binding]; other site 272622000905 Switch I region; other site 272622000906 G2 box; other site 272622000907 G3 box; other site 272622000908 Switch II region; other site 272622000909 G4 box; other site 272622000910 G5 box; other site 272622000911 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 272622000912 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 272622000913 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 272622000914 active site 272622000915 (T/H)XGH motif; other site 272622000916 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 272622000917 Zn2+ binding site [ion binding]; other site 272622000918 Mg2+ binding site [ion binding]; other site 272622000919 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272622000920 Coenzyme A binding pocket [chemical binding]; other site 272622000921 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 272622000922 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 272622000923 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272622000924 S-adenosylmethionine binding site [chemical binding]; other site 272622000925 hypothetical protein; Provisional; Region: PRK13670 272622000926 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; pfam05636 272622000927 hypothetical protein; Provisional; Region: PRK12378 272622000928 Uncharacterized conserved protein [Function unknown]; Region: COG4832 272622000929 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 272622000930 ligand binding site [chemical binding]; other site 272622000931 active site 272622000932 UGI interface [polypeptide binding]; other site 272622000933 catalytic site [active] 272622000934 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 272622000935 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 272622000936 putative NAD(P) binding site [chemical binding]; other site 272622000937 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272622000938 NADH(P)-binding; Region: NAD_binding_10; pfam13460 272622000939 NAD(P) binding site [chemical binding]; other site 272622000940 active site 272622000941 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 272622000942 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272622000943 NAD(P) binding site [chemical binding]; other site 272622000944 active site 272622000945 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 272622000946 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 272622000947 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 272622000948 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272622000949 putative substrate translocation pore; other site 272622000950 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 272622000951 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 272622000952 DNA binding residues [nucleotide binding] 272622000953 putative dimer interface [polypeptide binding]; other site 272622000954 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 272622000955 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 272622000956 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272622000957 active site 272622000958 motif I; other site 272622000959 motif II; other site 272622000960 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 272622000961 phosphoglycerate kinase; Provisional; Region: pgk; PRK00073 272622000962 Phosphoglycerate kinase; Region: PGK; pfam00162 272622000963 substrate binding site [chemical binding]; other site 272622000964 hinge regions; other site 272622000965 ADP binding site [chemical binding]; other site 272622000966 catalytic site [active] 272622000967 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 272622000968 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272622000969 motif II; other site 272622000970 DhaKLM operon coactivator DhaQ; Provisional; Region: PRK14483 272622000971 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 272622000972 phosphotransferase mannnose-specific family component IIA; Provisional; Region: PRK14484 272622000973 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 272622000974 amphipathic channel; other site 272622000975 Asn-Pro-Ala signature motifs; other site 272622000976 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 272622000977 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 272622000978 Walker A/P-loop; other site 272622000979 ATP binding site [chemical binding]; other site 272622000980 Q-loop/lid; other site 272622000981 ABC transporter signature motif; other site 272622000982 Walker B; other site 272622000983 D-loop; other site 272622000984 H-loop/switch region; other site 272622000985 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 272622000986 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 272622000987 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 272622000988 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 272622000989 putative RNA binding site [nucleotide binding]; other site 272622000990 Methyltransferase domain; Region: Methyltransf_26; pfam13659 272622000991 HI0933-like protein; Region: HI0933_like; pfam03486 272622000992 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 272622000993 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 272622000994 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 272622000995 putative substrate binding site [chemical binding]; other site 272622000996 putative ATP binding site [chemical binding]; other site 272622000997 Protein of unknown function (DUF1398); Region: DUF1398; cl11576 272622000998 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 272622000999 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 272622001000 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272622001001 Walker A/P-loop; other site 272622001002 ATP binding site [chemical binding]; other site 272622001003 Q-loop/lid; other site 272622001004 ABC transporter signature motif; other site 272622001005 Walker B; other site 272622001006 D-loop; other site 272622001007 H-loop/switch region; other site 272622001008 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 272622001009 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 272622001010 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 272622001011 Walker A/P-loop; other site 272622001012 ATP binding site [chemical binding]; other site 272622001013 Q-loop/lid; other site 272622001014 ABC transporter signature motif; other site 272622001015 Walker B; other site 272622001016 D-loop; other site 272622001017 H-loop/switch region; other site 272622001018 Uncharacterized protein/domain associated with GTPases [Function unknown]; Region: COG3597 272622001019 putative oxidoreductase; Provisional; Region: PRK10206 272622001020 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 272622001021 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 272622001022 S-ribosylhomocysteinase; Provisional; Region: PRK02260 272622001023 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 272622001024 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 272622001025 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 272622001026 active site 272622001027 catalytic tetrad [active] 272622001028 Isochorismatase family; Region: Isochorismatase; pfam00857 272622001029 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 272622001030 catalytic triad [active] 272622001031 conserved cis-peptide bond; other site 272622001032 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 272622001033 ATP cone domain; Region: ATP-cone; pfam03477 272622001034 Class III ribonucleotide reductase; Region: RNR_III; cd01675 272622001035 effector binding site; other site 272622001036 active site 272622001037 Zn binding site [ion binding]; other site 272622001038 glycine loop; other site 272622001039 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 272622001040 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272622001041 FeS/SAM binding site; other site 272622001042 Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; pfam10087 272622001043 Cytochrome c552; Region: Cytochrom_C552; pfam02335 272622001044 enolase; Provisional; Region: eno; PRK00077 272622001045 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 272622001046 dimer interface [polypeptide binding]; other site 272622001047 metal binding site [ion binding]; metal-binding site 272622001048 substrate binding pocket [chemical binding]; other site 272622001049 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 272622001050 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 272622001051 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13642 272622001052 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 272622001053 Walker A/P-loop; other site 272622001054 ATP binding site [chemical binding]; other site 272622001055 Q-loop/lid; other site 272622001056 ABC transporter signature motif; other site 272622001057 Walker B; other site 272622001058 D-loop; other site 272622001059 H-loop/switch region; other site 272622001060 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13643 272622001061 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 272622001062 Walker A/P-loop; other site 272622001063 ATP binding site [chemical binding]; other site 272622001064 Q-loop/lid; other site 272622001065 ABC transporter signature motif; other site 272622001066 Walker B; other site 272622001067 D-loop; other site 272622001068 H-loop/switch region; other site 272622001069 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 272622001070 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 272622001071 active site 272622001072 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 272622001073 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 272622001074 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 272622001075 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 272622001076 putative trimer interface [polypeptide binding]; other site 272622001077 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 272622001078 putative CoA binding site [chemical binding]; other site 272622001079 putative trimer interface [polypeptide binding]; other site 272622001080 putative CoA binding site [chemical binding]; other site 272622001081 M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670 272622001082 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 272622001083 metal binding site [ion binding]; metal-binding site 272622001084 putative dimer interface [polypeptide binding]; other site 272622001085 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 272622001086 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 272622001087 Glucosyl transferase GtrII; Region: Glucos_trans_II; cl10304 272622001088 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 272622001089 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 272622001090 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 272622001091 RNA binding surface [nucleotide binding]; other site 272622001092 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 272622001093 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 272622001094 Int/Topo IB signature motif; other site 272622001095 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 272622001096 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272622001097 non-specific DNA binding site [nucleotide binding]; other site 272622001098 salt bridge; other site 272622001099 sequence-specific DNA binding site [nucleotide binding]; other site 272622001100 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272622001101 salt bridge; other site 272622001102 non-specific DNA binding site [nucleotide binding]; other site 272622001103 sequence-specific DNA binding site [nucleotide binding]; other site 272622001104 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 272622001105 Protein of unknown function (DUF1655); Region: DUF1655; pfam07868 272622001106 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 272622001107 Protein of unknown function DUF262; Region: DUF262; pfam03235 272622001108 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 272622001109 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 272622001110 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 272622001111 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 272622001112 RNA binding site [nucleotide binding]; other site 272622001113 SprT homologues; Region: SprT; cl01182 272622001114 hypothetical protein; Provisional; Region: PRK04351 272622001115 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 272622001116 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 272622001117 active site 272622001118 purine riboside binding site [chemical binding]; other site 272622001119 SnoaL-like domain; Region: SnoaL_4; pfam13577 272622001120 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 272622001121 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 272622001122 DNA binding residues [nucleotide binding] 272622001123 putative dimer interface [polypeptide binding]; other site 272622001124 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 272622001125 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 272622001126 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 272622001127 hypothetical protein; Provisional; Region: PRK13667 272622001128 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 272622001129 Glycoprotease family; Region: Peptidase_M22; pfam00814 272622001130 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 272622001131 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272622001132 Coenzyme A binding pocket [chemical binding]; other site 272622001133 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272622001134 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 272622001135 Coenzyme A binding pocket [chemical binding]; other site 272622001136 UGMP family protein; Validated; Region: PRK09604 272622001137 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 272622001138 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 272622001139 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 272622001140 Walker A/P-loop; other site 272622001141 ATP binding site [chemical binding]; other site 272622001142 Q-loop/lid; other site 272622001143 ABC transporter signature motif; other site 272622001144 Walker B; other site 272622001145 D-loop; other site 272622001146 H-loop/switch region; other site 272622001147 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 272622001148 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272622001149 dimer interface [polypeptide binding]; other site 272622001150 conserved gate region; other site 272622001151 putative PBP binding loops; other site 272622001152 ABC-ATPase subunit interface; other site 272622001153 ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport and metabolism]; Region: COG3639 272622001154 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272622001155 dimer interface [polypeptide binding]; other site 272622001156 conserved gate region; other site 272622001157 ABC-ATPase subunit interface; other site 272622001158 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 272622001159 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 272622001160 active site 272622001161 metal binding site [ion binding]; metal-binding site 272622001162 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 272622001163 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 272622001164 dimer interface [polypeptide binding]; other site 272622001165 catalytic triad [active] 272622001166 peroxidatic and resolving cysteines [active] 272622001167 Aminopeptidase N [Amino acid transport and metabolism]; Region: PepN; COG0308 272622001168 Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601 272622001169 Zn binding site [ion binding]; other site 272622001170 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272622001171 putative substrate translocation pore; other site 272622001172 Major Facilitator Superfamily; Region: MFS_1; pfam07690 272622001173 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 272622001174 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 272622001175 Cation efflux family; Region: Cation_efflux; pfam01545 272622001176 Predicted transcriptional regulators [Transcription]; Region: COG1695 272622001177 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 272622001178 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 272622001179 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 272622001180 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272622001181 Walker A/P-loop; other site 272622001182 ATP binding site [chemical binding]; other site 272622001183 Q-loop/lid; other site 272622001184 ABC transporter signature motif; other site 272622001185 Walker B; other site 272622001186 D-loop; other site 272622001187 H-loop/switch region; other site 272622001188 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 272622001189 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 272622001190 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 272622001191 Walker A/P-loop; other site 272622001192 ATP binding site [chemical binding]; other site 272622001193 Q-loop/lid; other site 272622001194 ABC transporter signature motif; other site 272622001195 Walker B; other site 272622001196 D-loop; other site 272622001197 H-loop/switch region; other site 272622001198 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 272622001199 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 272622001200 hinge; other site 272622001201 active site 272622001202 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4443 272622001203 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 272622001204 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 272622001205 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 272622001206 Transposase; Region: HTH_Tnp_1; pfam01527 272622001207 Integrase core domain; Region: rve; pfam00665 272622001208 Integrase core domain; Region: rve_3; pfam13683 272622001209 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 272622001210 ATP binding site [chemical binding]; other site 272622001211 substrate interface [chemical binding]; other site 272622001212 H+ Antiporter protein; Region: 2A0121; TIGR00900 272622001213 BioY family; Region: BioY; pfam02632 272622001214 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 272622001215 putative deacylase active site [active] 272622001216 Predicted membrane protein [Function unknown]; Region: COG3859 272622001217 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 272622001218 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 272622001219 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 272622001220 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 272622001221 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 272622001222 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 272622001223 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272622001224 acetoin reductases; Region: 23BDH; TIGR02415 272622001225 NAD(P) binding site [chemical binding]; other site 272622001226 active site 272622001227 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 272622001228 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 272622001229 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 272622001230 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 272622001231 Walker A/P-loop; other site 272622001232 ATP binding site [chemical binding]; other site 272622001233 Q-loop/lid; other site 272622001234 ABC transporter signature motif; other site 272622001235 Walker B; other site 272622001236 D-loop; other site 272622001237 H-loop/switch region; other site 272622001238 NIL domain; Region: NIL; pfam09383 272622001239 ABC-type metal ion transport system, permease component [Inorganic ion transport and metabolism]; Region: AbcD; COG2011 272622001240 hypothetical protein; Provisional; Region: PRK13661 272622001241 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 272622001242 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 272622001243 Walker A/P-loop; other site 272622001244 ATP binding site [chemical binding]; other site 272622001245 Q-loop/lid; other site 272622001246 ABC transporter signature motif; other site 272622001247 Walker B; other site 272622001248 D-loop; other site 272622001249 H-loop/switch region; other site 272622001250 ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558 272622001251 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 272622001252 Walker A/P-loop; other site 272622001253 ATP binding site [chemical binding]; other site 272622001254 Q-loop/lid; other site 272622001255 ABC transporter signature motif; other site 272622001256 Walker B; other site 272622001257 D-loop; other site 272622001258 H-loop/switch region; other site 272622001259 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 272622001260 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 272622001261 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272622001262 non-specific DNA binding site [nucleotide binding]; other site 272622001263 salt bridge; other site 272622001264 sequence-specific DNA binding site [nucleotide binding]; other site 272622001265 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 272622001266 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 272622001267 Walker A/P-loop; other site 272622001268 ATP binding site [chemical binding]; other site 272622001269 Q-loop/lid; other site 272622001270 ABC transporter signature motif; other site 272622001271 Walker B; other site 272622001272 D-loop; other site 272622001273 H-loop/switch region; other site 272622001274 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 272622001275 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 272622001276 ABC-ATPase subunit interface; other site 272622001277 dimer interface [polypeptide binding]; other site 272622001278 putative PBP binding regions; other site 272622001279 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 272622001280 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 272622001281 ABC-ATPase subunit interface; other site 272622001282 dimer interface [polypeptide binding]; other site 272622001283 putative PBP binding regions; other site 272622001284 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 272622001285 putative ligand binding residues [chemical binding]; other site 272622001286 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 272622001287 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272622001288 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272622001289 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 272622001290 dimerization interface [polypeptide binding]; other site 272622001291 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 272622001292 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 272622001293 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 272622001294 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272622001295 putative substrate translocation pore; other site 272622001296 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 272622001297 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 272622001298 active site 272622001299 catalytic tetrad [active] 272622001300 Predicted transcriptional regulators [Transcription]; Region: COG1733 272622001301 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 272622001302 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 272622001303 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 272622001304 putative metal binding site [ion binding]; other site 272622001305 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 272622001306 catalytic core [active] 272622001307 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 272622001308 peroxiredoxin; Region: AhpC; TIGR03137 272622001309 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 272622001310 dimer interface [polypeptide binding]; other site 272622001311 decamer (pentamer of dimers) interface [polypeptide binding]; other site 272622001312 catalytic triad [active] 272622001313 peroxidatic and resolving cysteines [active] 272622001314 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 272622001315 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 272622001316 catalytic residue [active] 272622001317 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 272622001318 catalytic residues [active] 272622001319 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 272622001320 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 272622001321 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 272622001322 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 272622001323 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 272622001324 recombination protein RecR; Reviewed; Region: recR; PRK00076 272622001325 RecR protein; Region: RecR; pfam02132 272622001326 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 272622001327 putative active site [active] 272622001328 putative metal-binding site [ion binding]; other site 272622001329 tetramer interface [polypeptide binding]; other site 272622001330 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 272622001331 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 272622001332 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 272622001333 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 272622001334 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 272622001335 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 272622001336 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 272622001337 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 272622001338 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 272622001339 peptide binding site [polypeptide binding]; other site 272622001340 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 272622001341 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 272622001342 peptide binding site [polypeptide binding]; other site 272622001343 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 272622001344 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272622001345 dimer interface [polypeptide binding]; other site 272622001346 conserved gate region; other site 272622001347 putative PBP binding loops; other site 272622001348 ABC-ATPase subunit interface; other site 272622001349 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 272622001350 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 272622001351 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272622001352 dimer interface [polypeptide binding]; other site 272622001353 conserved gate region; other site 272622001354 putative PBP binding loops; other site 272622001355 ABC-ATPase subunit interface; other site 272622001356 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 272622001357 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 272622001358 Walker A/P-loop; other site 272622001359 ATP binding site [chemical binding]; other site 272622001360 Q-loop/lid; other site 272622001361 ABC transporter signature motif; other site 272622001362 Walker B; other site 272622001363 D-loop; other site 272622001364 H-loop/switch region; other site 272622001365 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 272622001366 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 272622001367 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 272622001368 Walker A/P-loop; other site 272622001369 ATP binding site [chemical binding]; other site 272622001370 Q-loop/lid; other site 272622001371 ABC transporter signature motif; other site 272622001372 Walker B; other site 272622001373 D-loop; other site 272622001374 H-loop/switch region; other site 272622001375 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 272622001376 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 272622001377 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 272622001378 G1 box; other site 272622001379 putative GEF interaction site [polypeptide binding]; other site 272622001380 GTP/Mg2+ binding site [chemical binding]; other site 272622001381 Switch I region; other site 272622001382 G2 box; other site 272622001383 G3 box; other site 272622001384 Switch II region; other site 272622001385 G4 box; other site 272622001386 G5 box; other site 272622001387 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 272622001388 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 272622001389 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 272622001390 ATP binding site [chemical binding]; other site 272622001391 Mg++ binding site [ion binding]; other site 272622001392 motif III; other site 272622001393 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272622001394 nucleotide binding region [chemical binding]; other site 272622001395 ATP-binding site [chemical binding]; other site 272622001396 GTPase Era; Reviewed; Region: era; PRK00089 272622001397 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 272622001398 G1 box; other site 272622001399 GTP/Mg2+ binding site [chemical binding]; other site 272622001400 Switch I region; other site 272622001401 G2 box; other site 272622001402 Switch II region; other site 272622001403 G3 box; other site 272622001404 G4 box; other site 272622001405 G5 box; other site 272622001406 KH domain; Region: KH_2; pfam07650 272622001407 asparagine synthetase B; Provisional; Region: asnB; PRK09431 272622001408 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 272622001409 dimer interface [polypeptide binding]; other site 272622001410 active site 272622001411 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 272622001412 Ligand Binding Site [chemical binding]; other site 272622001413 Molecular Tunnel; other site 272622001414 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 272622001415 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 272622001416 DNA binding site [nucleotide binding] 272622001417 catalytic residue [active] 272622001418 H2TH interface [polypeptide binding]; other site 272622001419 putative catalytic residues [active] 272622001420 turnover-facilitating residue; other site 272622001421 intercalation triad [nucleotide binding]; other site 272622001422 8OG recognition residue [nucleotide binding]; other site 272622001423 putative reading head residues; other site 272622001424 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 272622001425 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 272622001426 recombinase A; Provisional; Region: recA; PRK09354 272622001427 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 272622001428 hexamer interface [polypeptide binding]; other site 272622001429 Walker A motif; other site 272622001430 ATP binding site [chemical binding]; other site 272622001431 Walker B motif; other site 272622001432 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 272622001433 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 272622001434 Protein of unknown function (DUF964); Region: DUF964; cl01483 272622001435 Uncharacterized protein conserved in bacteria (DUF2129); Region: DUF2129; pfam09902 272622001436 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 272622001437 putative active site [active] 272622001438 putative triphosphate binding site [ion binding]; other site 272622001439 putative metal binding residues [ion binding]; other site 272622001440 Protein of unknown function (DUF817); Region: DUF817; pfam05675 272622001441 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 272622001442 synthetase active site [active] 272622001443 NTP binding site [chemical binding]; other site 272622001444 metal binding site [ion binding]; metal-binding site 272622001445 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 272622001446 ATP-NAD kinase; Region: NAD_kinase; pfam01513 272622001447 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 272622001448 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 272622001449 active site 272622001450 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 272622001451 active site 272622001452 lysine transporter; Provisional; Region: PRK10836 272622001453 Predicted flavoprotein [General function prediction only]; Region: COG0431 272622001454 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 272622001455 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 272622001456 ApbE family; Region: ApbE; pfam02424 272622001457 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 272622001458 Helix-turn-helix domain; Region: HTH_28; pfam13518 272622001459 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 272622001460 putative transposase OrfB; Reviewed; Region: PHA02517 272622001461 HTH-like domain; Region: HTH_21; pfam13276 272622001462 Integrase core domain; Region: rve; pfam00665 272622001463 Integrase core domain; Region: rve_2; pfam13333 272622001464 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 272622001465 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 272622001466 dimer interface [polypeptide binding]; other site 272622001467 putative anticodon binding site; other site 272622001468 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 272622001469 motif 1; other site 272622001470 active site 272622001471 motif 2; other site 272622001472 motif 3; other site 272622001473 Conserved hypothetical protein 698; Region: Cons_hypoth698; pfam03601 272622001474 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 272622001475 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 272622001476 tetramer (dimer of dimers) interface [polypeptide binding]; other site 272622001477 NAD binding site [chemical binding]; other site 272622001478 dimer interface [polypeptide binding]; other site 272622001479 substrate binding site [chemical binding]; other site 272622001480 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272622001481 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272622001482 LysR substrate binding domain; Region: LysR_substrate; pfam03466 272622001483 dimerization interface [polypeptide binding]; other site 272622001484 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 272622001485 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 272622001486 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 272622001487 C4-dicarboxylate transporters of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_C4-dicarb_trans; cd09325 272622001488 gating phenylalanine in ion channel; other site 272622001489 Acyl carrier protein phosphodiesterase [Lipid metabolism]; Region: AcpD; COG1182 272622001490 OsmC-like protein; Region: OsmC; cl00767 272622001491 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 272622001492 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 272622001493 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 272622001494 active site 272622001495 HIGH motif; other site 272622001496 dimer interface [polypeptide binding]; other site 272622001497 KMSKS motif; other site 272622001498 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 272622001499 RNA binding surface [nucleotide binding]; other site 272622001500 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 272622001501 Transglycosylase; Region: Transgly; pfam00912 272622001502 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 272622001503 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 272622001504 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 272622001505 oligomer interface [polypeptide binding]; other site 272622001506 active site 272622001507 metal binding site [ion binding]; metal-binding site 272622001508 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 272622001509 catalytic residues [active] 272622001510 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 272622001511 putative tRNA-binding site [nucleotide binding]; other site 272622001512 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 272622001513 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 272622001514 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 272622001515 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 272622001516 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 272622001517 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 272622001518 dimer interface [polypeptide binding]; other site 272622001519 ssDNA binding site [nucleotide binding]; other site 272622001520 tetramer (dimer of dimers) interface [polypeptide binding]; other site 272622001521 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 272622001522 oligomerisation interface [polypeptide binding]; other site 272622001523 mobile loop; other site 272622001524 roof hairpin; other site 272622001525 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 272622001526 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 272622001527 ring oligomerisation interface [polypeptide binding]; other site 272622001528 ATP/Mg binding site [chemical binding]; other site 272622001529 stacking interactions; other site 272622001530 hinge regions; other site 272622001531 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 272622001532 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 272622001533 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 272622001534 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272622001535 putative active site [active] 272622001536 heme pocket [chemical binding]; other site 272622001537 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272622001538 dimer interface [polypeptide binding]; other site 272622001539 phosphorylation site [posttranslational modification] 272622001540 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272622001541 ATP binding site [chemical binding]; other site 272622001542 Mg2+ binding site [ion binding]; other site 272622001543 G-X-G motif; other site 272622001544 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 272622001545 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272622001546 active site 272622001547 phosphorylation site [posttranslational modification] 272622001548 intermolecular recognition site; other site 272622001549 dimerization interface [polypeptide binding]; other site 272622001550 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272622001551 DNA binding site [nucleotide binding] 272622001552 thymidylate kinase; Validated; Region: tmk; PRK00698 272622001553 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 272622001554 TMP-binding site; other site 272622001555 ATP-binding site [chemical binding]; other site 272622001556 DNA polymerase III subunit delta'; Validated; Region: PRK07276 272622001557 DNA polymerase III subunit delta'; Validated; Region: PRK08485 272622001558 PSP1 C-terminal conserved region; Region: PSP1; cl00770 272622001559 Regulator of replication initiation timing [Replication, recombination, and repair]; Region: COG4467 272622001560 Predicted methyltransferases [General function prediction only]; Region: COG0313 272622001561 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 272622001562 putative SAM binding site [chemical binding]; other site 272622001563 putative homodimer interface [polypeptide binding]; other site 272622001564 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 272622001565 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 272622001566 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272622001567 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 272622001568 Walker A/P-loop; other site 272622001569 ATP binding site [chemical binding]; other site 272622001570 Q-loop/lid; other site 272622001571 ABC transporter signature motif; other site 272622001572 Walker B; other site 272622001573 D-loop; other site 272622001574 H-loop/switch region; other site 272622001575 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 272622001576 MarR family; Region: MarR_2; pfam12802 272622001577 mevalonate kinase; Region: mevalon_kin; TIGR00549 272622001578 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 272622001579 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 272622001580 Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407 272622001581 diphosphomevalonate decarboxylase; Region: PLN02407 272622001582 Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577 272622001583 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 272622001584 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 272622001585 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 272622001586 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 272622001587 homotetramer interface [polypeptide binding]; other site 272622001588 FMN binding site [chemical binding]; other site 272622001589 homodimer contacts [polypeptide binding]; other site 272622001590 putative active site [active] 272622001591 putative substrate binding site [chemical binding]; other site 272622001592 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 272622001593 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 272622001594 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 272622001595 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 272622001596 Carbon starvation protein CstA; Region: CstA; pfam02554 272622001597 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 272622001598 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 272622001599 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 272622001600 DEAD-like helicases superfamily; Region: DEXDc; smart00487 272622001601 ATP binding site [chemical binding]; other site 272622001602 Mg++ binding site [ion binding]; other site 272622001603 motif III; other site 272622001604 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272622001605 nucleotide binding region [chemical binding]; other site 272622001606 ATP-binding site [chemical binding]; other site 272622001607 Uncharacterized conserved protein [Function unknown]; Region: COG1434 272622001608 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 272622001609 putative active site [active] 272622001610 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 272622001611 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 272622001612 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 272622001613 putative active site [active] 272622001614 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 272622001615 active site 272622001616 P-loop; other site 272622001617 phosphorylation site [posttranslational modification] 272622001618 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 272622001619 active site 272622001620 methionine cluster; other site 272622001621 phosphorylation site [posttranslational modification] 272622001622 metal binding site [ion binding]; metal-binding site 272622001623 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 272622001624 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 272622001625 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 272622001626 putative active site [active] 272622001627 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 272622001628 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 272622001629 6-phospho-beta-glucosidase; Reviewed; Region: celA; PRK09589 272622001630 beta-galactosidase; Region: BGL; TIGR03356 272622001631 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 272622001632 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 272622001633 nucleotide binding pocket [chemical binding]; other site 272622001634 K-X-D-G motif; other site 272622001635 catalytic site [active] 272622001636 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 272622001637 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 272622001638 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 272622001639 BRCT sequence motif; other site 272622001640 putative lipid kinase; Reviewed; Region: PRK13055 272622001641 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 272622001642 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 272622001643 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 272622001644 Walker A/P-loop; other site 272622001645 ATP binding site [chemical binding]; other site 272622001646 Q-loop/lid; other site 272622001647 ABC transporter signature motif; other site 272622001648 Walker B; other site 272622001649 D-loop; other site 272622001650 H-loop/switch region; other site 272622001651 TOBE domain; Region: TOBE_2; pfam08402 272622001652 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 272622001653 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 272622001654 dimer interface [polypeptide binding]; other site 272622001655 PYR/PP interface [polypeptide binding]; other site 272622001656 TPP binding site [chemical binding]; other site 272622001657 substrate binding site [chemical binding]; other site 272622001658 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 272622001659 Domain of unknown function; Region: EKR; smart00890 272622001660 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 272622001661 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 272622001662 TPP-binding site [chemical binding]; other site 272622001663 dimer interface [polypeptide binding]; other site 272622001664 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 272622001665 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 272622001666 Uncharacterized conserved protein [Function unknown]; Region: COG1624 272622001667 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 272622001668 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 272622001669 YbbR-like protein; Region: YbbR; pfam07949 272622001670 YbbR-like protein; Region: YbbR; pfam07949 272622001671 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 272622001672 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 272622001673 active site 272622001674 substrate binding site [chemical binding]; other site 272622001675 metal binding site [ion binding]; metal-binding site 272622001676 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 272622001677 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 272622001678 DNA-binding site [nucleotide binding]; DNA binding site 272622001679 UTRA domain; Region: UTRA; pfam07702 272622001680 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 272622001681 HPr interaction site; other site 272622001682 glycerol kinase (GK) interaction site [polypeptide binding]; other site 272622001683 active site 272622001684 phosphorylation site [posttranslational modification] 272622001685 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 272622001686 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 272622001687 active site turn [active] 272622001688 phosphorylation site [posttranslational modification] 272622001689 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 272622001690 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 272622001691 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 272622001692 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 272622001693 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 272622001694 beta-phosphoglucomutase; Region: bPGM; TIGR01990 272622001695 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272622001696 motif II; other site 272622001697 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 272622001698 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 272622001699 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 272622001700 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 272622001701 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272622001702 Coenzyme A binding pocket [chemical binding]; other site 272622001703 Transcriptional regulator [Transcription]; Region: LytR; COG1316 272622001704 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 272622001705 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 272622001706 dimerization interface 3.5A [polypeptide binding]; other site 272622001707 active site 272622001708 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 272622001709 dimer interface [polypeptide binding]; other site 272622001710 substrate binding site [chemical binding]; other site 272622001711 ATP binding site [chemical binding]; other site 272622001712 Predicted membrane protein [Function unknown]; Region: COG4720 272622001713 hypothetical protein; Provisional; Region: PRK13690 272622001714 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 272622001715 CTP synthetase; Validated; Region: pyrG; PRK05380 272622001716 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 272622001717 Catalytic site [active] 272622001718 active site 272622001719 UTP binding site [chemical binding]; other site 272622001720 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 272622001721 active site 272622001722 putative oxyanion hole; other site 272622001723 catalytic triad [active] 272622001724 Domain of unknown function (DUF4288); Region: DUF4288; pfam14119 272622001725 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 272622001726 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 272622001727 NAD(P) binding site [chemical binding]; other site 272622001728 LDH/MDH dimer interface [polypeptide binding]; other site 272622001729 substrate binding site [chemical binding]; other site 272622001730 Predicted membrane protein [Function unknown]; Region: COG4420 272622001731 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 272622001732 Possible lysine decarboxylase; Region: Lysine_decarbox; pfam03641 272622001733 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 272622001734 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 272622001735 Substrate-binding site [chemical binding]; other site 272622001736 Substrate specificity [chemical binding]; other site 272622001737 Transposase, Mutator family; Region: Transposase_mut; pfam00872 272622001738 MULE transposase domain; Region: MULE; pfam10551 272622001739 Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529 272622001740 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK07279 272622001741 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 272622001742 active site 272622001743 PHP Thumb interface [polypeptide binding]; other site 272622001744 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 272622001745 generic binding surface II; other site 272622001746 generic binding surface I; other site 272622001747 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 272622001748 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 272622001749 EDD domain protein, DegV family; Region: DegV; TIGR00762 272622001750 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 272622001751 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 272622001752 active site 272622001753 catalytic triad [active] 272622001754 oxyanion hole [active] 272622001755 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 272622001756 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 272622001757 Uncharacterized protein conserved in bacteria (DUF2140); Region: DUF2140; cl11548 272622001758 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 272622001759 IHF dimer interface [polypeptide binding]; other site 272622001760 IHF - DNA interface [nucleotide binding]; other site 272622001761 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 272622001762 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272622001763 Coenzyme A binding pocket [chemical binding]; other site 272622001764 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 272622001765 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 272622001766 Walker A/P-loop; other site 272622001767 ATP binding site [chemical binding]; other site 272622001768 Q-loop/lid; other site 272622001769 ABC transporter signature motif; other site 272622001770 Walker B; other site 272622001771 D-loop; other site 272622001772 H-loop/switch region; other site 272622001773 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 272622001774 ABC-2 type transporter; Region: ABC2_membrane; cl17235 272622001775 LytTr DNA-binding domain; Region: LytTR; smart00850 272622001776 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 272622001777 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 272622001778 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 272622001779 catalytic residue [active] 272622001780 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 272622001781 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 272622001782 NlpC/P60 family; Region: NLPC_P60; cl17555 272622001783 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 272622001784 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 272622001785 peptide binding site [polypeptide binding]; other site 272622001786 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 272622001787 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 272622001788 dimer interface [polypeptide binding]; other site 272622001789 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272622001790 catalytic residue [active] 272622001791 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 272622001792 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 272622001793 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 272622001794 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 272622001795 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 272622001796 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 272622001797 Integrase core domain; Region: rve; pfam00665 272622001798 Transglycosylase; Region: Transgly; pfam00912 272622001799 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 272622001800 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 272622001801 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 272622001802 hypothetical protein; Provisional; Region: PRK13660 272622001803 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 272622001804 ArsC family; Region: ArsC; pfam03960 272622001805 putative catalytic residues [active] 272622001806 thiol/disulfide switch; other site 272622001807 hypothetical protein; Provisional; Region: PRK04387 272622001808 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 272622001809 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 272622001810 active site 272622001811 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 272622001812 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 272622001813 hinge; other site 272622001814 active site 272622001815 trigger factor; Provisional; Region: tig; PRK01490 272622001816 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 272622001817 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 272622001818 Transposase, Mutator family; Region: Transposase_mut; pfam00872 272622001819 MULE transposase domain; Region: MULE; pfam10551 272622001820 DNA primase, catalytic core; Region: dnaG; TIGR01391 272622001821 CHC2 zinc finger; Region: zf-CHC2; pfam01807 272622001822 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 272622001823 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 272622001824 active site 272622001825 metal binding site [ion binding]; metal-binding site 272622001826 interdomain interaction site; other site 272622001827 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 272622001828 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 272622001829 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 272622001830 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 272622001831 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 272622001832 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 272622001833 DNA binding residues [nucleotide binding] 272622001834 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 272622001835 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272622001836 putative substrate translocation pore; other site 272622001837 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272622001838 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 272622001839 Double zinc ribbon; Region: DZR; pfam12773 272622001840 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272622001841 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 272622001842 Walker A motif; other site 272622001843 ATP binding site [chemical binding]; other site 272622001844 Walker B motif; other site 272622001845 arginine finger; other site 272622001846 UvrB/uvrC motif; Region: UVR; pfam02151 272622001847 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272622001848 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 272622001849 Walker A motif; other site 272622001850 ATP binding site [chemical binding]; other site 272622001851 Walker B motif; other site 272622001852 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 272622001853 Predicted transcriptional regulator [Transcription]; Region: COG1959 272622001854 Transcriptional regulator; Region: Rrf2; pfam02082 272622001855 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 272622001856 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 272622001857 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 272622001858 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 272622001859 active site 272622001860 catalytic residues [active] 272622001861 metal binding site [ion binding]; metal-binding site 272622001862 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 272622001863 putative active site [active] 272622001864 Ap4A binding site [chemical binding]; other site 272622001865 nudix motif; other site 272622001866 putative metal binding site [ion binding]; other site 272622001867 excinuclease ABC subunit B; Provisional; Region: PRK05298 272622001868 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272622001869 ATP binding site [chemical binding]; other site 272622001870 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272622001871 nucleotide binding region [chemical binding]; other site 272622001872 ATP-binding site [chemical binding]; other site 272622001873 Ultra-violet resistance protein B; Region: UvrB; pfam12344 272622001874 UvrB/uvrC motif; Region: UVR; pfam02151 272622001875 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 272622001876 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 272622001877 substrate binding pocket [chemical binding]; other site 272622001878 membrane-bound complex binding site; other site 272622001879 hinge residues; other site 272622001880 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 272622001881 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK06079 272622001882 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 272622001883 NAD binding site [chemical binding]; other site 272622001884 homotetramer interface [polypeptide binding]; other site 272622001885 homodimer interface [polypeptide binding]; other site 272622001886 substrate binding site [chemical binding]; other site 272622001887 active site 272622001888 OxaA-like protein precursor; Provisional; Region: PRK02463 272622001889 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 272622001890 Eukaryotic phosphomannomutase; Region: PMM; cl17107 272622001891 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 272622001892 Predicted membrane protein [Function unknown]; Region: COG4684 272622001893 phosphopantothenate--cysteine ligase; Validated; Region: PRK06732 272622001894 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 272622001895 active site 1 [active] 272622001896 dimer interface [polypeptide binding]; other site 272622001897 hexamer interface [polypeptide binding]; other site 272622001898 active site 2 [active] 272622001899 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 272622001900 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 272622001901 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272622001902 motif II; other site 272622001903 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 272622001904 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272622001905 Coenzyme A binding pocket [chemical binding]; other site 272622001906 putative transposase OrfB; Reviewed; Region: PHA02517 272622001907 HTH-like domain; Region: HTH_21; pfam13276 272622001908 Integrase core domain; Region: rve; pfam00665 272622001909 Integrase core domain; Region: rve_3; pfam13683 272622001910 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 272622001911 Transposase; Region: HTH_Tnp_1; pfam01527 272622001912 Replication initiation factor; Region: Rep_trans; pfam02486 272622001913 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 272622001914 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 272622001915 Int/Topo IB signature motif; other site 272622001916 thymidine kinase; Provisional; Region: PRK04296 272622001917 peptide chain release factor 1; Validated; Region: prfA; PRK00591 272622001918 This domain is found in peptide chain release factors; Region: PCRF; smart00937 272622001919 RF-1 domain; Region: RF-1; pfam00472 272622001920 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 272622001921 dimer interface [polypeptide binding]; other site 272622001922 FMN binding site [chemical binding]; other site 272622001923 NADPH bind site [chemical binding]; other site 272622001924 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 272622001925 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272622001926 S-adenosylmethionine binding site [chemical binding]; other site 272622001927 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 272622001928 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 272622001929 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 272622001930 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 272622001931 dimer interface [polypeptide binding]; other site 272622001932 active site 272622001933 glycine-pyridoxal phosphate binding site [chemical binding]; other site 272622001934 folate binding site [chemical binding]; other site 272622001935 Lysozyme-like; Region: Lysozyme_like; pfam13702 272622001936 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 272622001937 3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355 272622001938 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 272622001939 catalytic residue [active] 272622001940 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_3; cd12174 272622001941 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 272622001942 putative ligand binding site [chemical binding]; other site 272622001943 putative NAD binding site [chemical binding]; other site 272622001944 putative catalytic site [active] 272622001945 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 272622001946 phosphoserine phosphatase SerB; Region: serB; TIGR00338 272622001947 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272622001948 motif II; other site 272622001949 acylphosphatase; Provisional; Region: PRK14434 272622001950 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 272622001951 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 272622001952 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 272622001953 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 272622001954 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 272622001955 Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047 272622001956 DNA binding residues [nucleotide binding] 272622001957 putative dimer interface [polypeptide binding]; other site 272622001958 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cl00217 272622001959 dimer interface [polypeptide binding]; other site 272622001960 flavodoxin; Validated; Region: PRK07308 272622001961 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272622001962 Major Facilitator Superfamily; Region: MFS_1; pfam07690 272622001963 putative substrate translocation pore; other site 272622001964 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272622001965 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 272622001966 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 272622001967 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 272622001968 active site 272622001969 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 272622001970 Predicted membrane protein [Function unknown]; Region: COG2246 272622001971 GtrA-like protein; Region: GtrA; pfam04138 272622001972 Tim44-like domain; Region: Tim44; cl09208 272622001973 Protein of unknown function (DUF1294); Region: DUF1294; cl01311 272622001974 Protein of unknown function (DUF3272); Region: DUF3272; pfam11676 272622001975 HPr kinase/phosphorylase; Provisional; Region: PRK05428 272622001976 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 272622001977 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 272622001978 Hpr binding site; other site 272622001979 active site 272622001980 homohexamer subunit interaction site [polypeptide binding]; other site 272622001981 Prolipoprotein diacylglyceryl transferase; Region: LGT; pfam01790 272622001982 Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768 272622001983 YtxH-like protein; Region: YtxH; cl02079 272622001984 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 272622001985 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 272622001986 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 272622001987 K+ potassium transporter; Region: K_trans; cl15781 272622001988 K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158 272622001989 Protein of unknown function (DUF3042); Region: DUF3042; pfam11240 272622001990 Uncharacterized conserved protein [Function unknown]; Region: COG1284 272622001991 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 272622001992 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 272622001993 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 272622001994 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 272622001995 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_4; cd03407 272622001996 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272622001997 non-specific DNA binding site [nucleotide binding]; other site 272622001998 salt bridge; other site 272622001999 sequence-specific DNA binding site [nucleotide binding]; other site 272622002000 Lactococcus bacteriophage repressor; Region: Lac_bphage_repr; pfam06543 272622002001 ribonuclease Z; Region: RNase_Z; TIGR02651 272622002002 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 272622002003 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272622002004 NAD(P) binding site [chemical binding]; other site 272622002005 active site 272622002006 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 272622002007 DHH family; Region: DHH; pfam01368 272622002008 DHHA1 domain; Region: DHHA1; pfam02272 272622002009 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4199 272622002010 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 272622002011 active site 272622002012 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 272622002013 Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559 272622002014 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 272622002015 dimerization interface [polypeptide binding]; other site 272622002016 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 272622002017 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 272622002018 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 272622002019 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 272622002020 Helix-turn-helix domain; Region: HTH_28; pfam13518 272622002021 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 272622002022 Homeodomain-like domain; Region: HTH_23; cl17451 272622002023 putative transposase OrfB; Reviewed; Region: PHA02517 272622002024 HTH-like domain; Region: HTH_21; pfam13276 272622002025 Integrase core domain; Region: rve; pfam00665 272622002026 Integrase core domain; Region: rve_2; pfam13333 272622002027 putative transposase OrfB; Reviewed; Region: PHA02517 272622002028 HTH-like domain; Region: HTH_21; pfam13276 272622002029 Integrase core domain; Region: rve; pfam00665 272622002030 Integrase core domain; Region: rve_3; pfam13683 272622002031 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 272622002032 Transposase; Region: HTH_Tnp_1; pfam01527 272622002033 Transcriptional repressor of class III stress genes [Transcription]; Region: CtsR; COG4463 272622002034 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 272622002035 Clp amino terminal domain; Region: Clp_N; pfam02861 272622002036 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272622002037 Walker A motif; other site 272622002038 ATP binding site [chemical binding]; other site 272622002039 Walker B motif; other site 272622002040 arginine finger; other site 272622002041 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272622002042 Walker A motif; other site 272622002043 ATP binding site [chemical binding]; other site 272622002044 Walker B motif; other site 272622002045 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 272622002046 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 272622002047 30S subunit binding site; other site 272622002048 enolase; Provisional; Region: eno; PRK00077 272622002049 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 272622002050 dimer interface [polypeptide binding]; other site 272622002051 metal binding site [ion binding]; metal-binding site 272622002052 substrate binding pocket [chemical binding]; other site 272622002053 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 272622002054 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 272622002055 active site 272622002056 DNA binding site [nucleotide binding] 272622002057 Int/Topo IB signature motif; other site 272622002058 Transposase, Mutator family; Region: Transposase_mut; pfam00872 272622002059 MULE transposase domain; Region: MULE; pfam10551 272622002060 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 272622002061 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 272622002062 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 272622002063 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 272622002064 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 272622002065 Transposase; Region: HTH_Tnp_1; pfam01527 272622002066 putative transposase OrfB; Reviewed; Region: PHA02517 272622002067 HTH-like domain; Region: HTH_21; pfam13276 272622002068 Integrase core domain; Region: rve; pfam00665 272622002069 Integrase core domain; Region: rve_3; pfam13683 272622002070 Bacteriophage abortive infection AbiH; Region: AbiH; pfam14253 272622002071 putative transposase OrfB; Reviewed; Region: PHA02517 272622002072 HTH-like domain; Region: HTH_21; pfam13276 272622002073 Integrase core domain; Region: rve; pfam00665 272622002074 Integrase core domain; Region: rve_3; pfam13683 272622002075 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 272622002076 Transposase; Region: HTH_Tnp_1; pfam01527 272622002077 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 272622002078 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 272622002079 Walker A/P-loop; other site 272622002080 ATP binding site [chemical binding]; other site 272622002081 Q-loop/lid; other site 272622002082 ABC transporter signature motif; other site 272622002083 Walker B; other site 272622002084 D-loop; other site 272622002085 H-loop/switch region; other site 272622002086 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 272622002087 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 272622002088 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 272622002089 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 272622002090 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 272622002091 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 272622002092 acyl-activating enzyme (AAE) consensus motif; other site 272622002093 acyl-activating enzyme (AAE) consensus motif; other site 272622002094 AMP binding site [chemical binding]; other site 272622002095 active site 272622002096 CoA binding site [chemical binding]; other site 272622002097 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 272622002098 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 272622002099 Cl binding site [ion binding]; other site 272622002100 oligomer interface [polypeptide binding]; other site 272622002101 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 272622002102 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 272622002103 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 272622002104 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 272622002105 CoA-binding site [chemical binding]; other site 272622002106 ATP-binding [chemical binding]; other site 272622002107 drug efflux system protein MdtG; Provisional; Region: PRK09874 272622002108 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272622002109 putative substrate translocation pore; other site 272622002110 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 272622002111 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 272622002112 pyruvate carboxylase; Reviewed; Region: PRK12999 272622002113 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 272622002114 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 272622002115 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 272622002116 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 272622002117 active site 272622002118 catalytic residues [active] 272622002119 metal binding site [ion binding]; metal-binding site 272622002120 homodimer binding site [polypeptide binding]; other site 272622002121 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 272622002122 carboxyltransferase (CT) interaction site; other site 272622002123 biotinylation site [posttranslational modification]; other site 272622002124 Isocitrate dehydrogenases [Energy production and conversion]; Region: Icd; COG0538 272622002125 isocitrate dehydrogenase; Validated; Region: PRK07362 272622002126 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 272622002127 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 272622002128 oligomer interface [polypeptide binding]; other site 272622002129 active site residues [active] 272622002130 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 272622002131 ArsC family; Region: ArsC; pfam03960 272622002132 putative catalytic residues [active] 272622002133 thiol/disulfide switch; other site 272622002134 Transposase, Mutator family; Region: Transposase_mut; pfam00872 272622002135 MULE transposase domain; Region: MULE; pfam10551 272622002136 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 272622002137 Transposase; Region: HTH_Tnp_1; pfam01527 272622002138 putative transposase OrfB; Reviewed; Region: PHA02517 272622002139 HTH-like domain; Region: HTH_21; pfam13276 272622002140 Integrase core domain; Region: rve; pfam00665 272622002141 Integrase core domain; Region: rve_3; pfam13683 272622002142 N-glycosyltransferase; Provisional; Region: PRK11204 272622002143 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 272622002144 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 272622002145 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 272622002146 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 272622002147 Predicted acetyltransferase [General function prediction only]; Region: COG2388 272622002148 Uncharacterized conserved protein [Function unknown]; Region: COG3592 272622002149 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 272622002150 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 272622002151 active site 272622002152 topology modulation protein; Reviewed; Region: PRK08118 272622002153 AAA domain; Region: AAA_17; pfam13207 272622002154 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 272622002155 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 272622002156 putative active site [active] 272622002157 putative metal binding site [ion binding]; other site 272622002158 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 272622002159 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 272622002160 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 272622002161 S-adenosylmethionine binding site [chemical binding]; other site 272622002162 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 272622002163 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 272622002164 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 272622002165 active site 272622002166 elongation factor P; Validated; Region: PRK00529 272622002167 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 272622002168 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 272622002169 RNA binding site [nucleotide binding]; other site 272622002170 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 272622002171 RNA binding site [nucleotide binding]; other site 272622002172 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 272622002173 Transcription termination factor [Transcription]; Region: NusB; COG0781 272622002174 4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711 272622002175 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 272622002176 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 272622002177 ligand binding site; other site 272622002178 oligomer interface; other site 272622002179 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 272622002180 dimer interface [polypeptide binding]; other site 272622002181 N-terminal domain interface [polypeptide binding]; other site 272622002182 sulfate 1 binding site; other site 272622002183 glycogen synthase; Provisional; Region: glgA; PRK00654 272622002184 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 272622002185 ADP-binding pocket [chemical binding]; other site 272622002186 homodimer interface [polypeptide binding]; other site 272622002187 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 272622002188 homodimer interface [polypeptide binding]; other site 272622002189 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 272622002190 active site pocket [active] 272622002191 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 272622002192 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 272622002193 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 272622002194 active site 272622002195 homodimer interface [polypeptide binding]; other site 272622002196 catalytic site [active] 272622002197 COMC family; Region: ComC; pfam03047 272622002198 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272622002199 non-specific DNA binding site [nucleotide binding]; other site 272622002200 salt bridge; other site 272622002201 sequence-specific DNA binding site [nucleotide binding]; other site 272622002202 CAAX protease self-immunity; Region: Abi; pfam02517 272622002203 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 272622002204 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 272622002205 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 272622002206 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272622002207 putative substrate translocation pore; other site 272622002208 POT family; Region: PTR2; pfam00854 272622002209 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 272622002210 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 272622002211 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 272622002212 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 272622002213 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 272622002214 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 272622002215 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272622002216 Walker A/P-loop; other site 272622002217 ATP binding site [chemical binding]; other site 272622002218 Q-loop/lid; other site 272622002219 ABC transporter signature motif; other site 272622002220 Walker B; other site 272622002221 D-loop; other site 272622002222 H-loop/switch region; other site 272622002223 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 272622002224 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 272622002225 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272622002226 Walker A/P-loop; other site 272622002227 ATP binding site [chemical binding]; other site 272622002228 Q-loop/lid; other site 272622002229 ABC transporter signature motif; other site 272622002230 Walker B; other site 272622002231 D-loop; other site 272622002232 H-loop/switch region; other site 272622002233 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 272622002234 putative DNA binding site [nucleotide binding]; other site 272622002235 putative Zn2+ binding site [ion binding]; other site 272622002236 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 272622002237 Flavodoxin domain; Region: Flavodoxin_5; cl17428 272622002238 NnaC (CMP-NeuNAc synthetase) _like subfamily of SGNH_hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: NnaC_like; cd01841 272622002239 active site 272622002240 oxyanion hole [active] 272622002241 catalytic triad [active] 272622002242 Predicted integral membrane protein [Function unknown]; Region: COG3548 272622002243 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 272622002244 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 272622002245 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 272622002246 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 272622002247 Walker A/P-loop; other site 272622002248 ATP binding site [chemical binding]; other site 272622002249 Q-loop/lid; other site 272622002250 ABC transporter signature motif; other site 272622002251 Walker B; other site 272622002252 D-loop; other site 272622002253 H-loop/switch region; other site 272622002254 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 272622002255 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 272622002256 FtsX-like permease family; Region: FtsX; pfam02687 272622002257 Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082); Region: DUF2082; pfam09855 272622002258 Predicted membrane protein [Function unknown]; Region: COG3619 272622002259 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 272622002260 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 272622002261 putative NAD(P) binding site [chemical binding]; other site 272622002262 dimer interface [polypeptide binding]; other site 272622002263 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 272622002264 substrate binding site [chemical binding]; other site 272622002265 THF binding site; other site 272622002266 zinc-binding site [ion binding]; other site 272622002267 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 272622002268 DNA-binding site [nucleotide binding]; DNA binding site 272622002269 RNA-binding motif; other site 272622002270 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 272622002271 DNA-binding site [nucleotide binding]; DNA binding site 272622002272 RNA-binding motif; other site 272622002273 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 272622002274 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 272622002275 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 272622002276 active site 272622002277 metal binding site [ion binding]; metal-binding site 272622002278 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 272622002279 nucleoside/Zn binding site; other site 272622002280 dimer interface [polypeptide binding]; other site 272622002281 catalytic motif [active] 272622002282 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 272622002283 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272622002284 dimer interface [polypeptide binding]; other site 272622002285 conserved gate region; other site 272622002286 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 272622002287 ABC-ATPase subunit interface; other site 272622002288 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 272622002289 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272622002290 dimer interface [polypeptide binding]; other site 272622002291 conserved gate region; other site 272622002292 ABC-ATPase subunit interface; other site 272622002293 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 272622002294 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 272622002295 Protein of unknown function, DUF624; Region: DUF624; pfam04854 272622002296 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 272622002297 This family represents an uncharacterized glycosyl hydrolase family 31 (GH31) enzyme found in bacteria and eukaryotes that is related to the XylS xylosidase of Sulfolobus solfataricus. Alpha-xylosidases catalyze the release of an alpha-xylose residue...; Region: GH31_xylosidase_XylS-like; cd06595 272622002298 putative active site [active] 272622002299 putative catalytic site [active] 272622002300 Transcriptional regulators [Transcription]; Region: PurR; COG1609 272622002301 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 272622002302 DNA binding site [nucleotide binding] 272622002303 domain linker motif; other site 272622002304 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 272622002305 dimerization interface [polypeptide binding]; other site 272622002306 ligand binding site [chemical binding]; other site 272622002307 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 272622002308 CoenzymeA binding site [chemical binding]; other site 272622002309 subunit interaction site [polypeptide binding]; other site 272622002310 PHB binding site; other site 272622002311 N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317 272622002312 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 272622002313 active site 272622002314 octamer interface [polypeptide binding]; other site 272622002315 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 272622002316 O-succinylbenzoate-CoA ligase; Region: menE; TIGR01923 272622002317 acyl-activating enzyme (AAE) consensus motif; other site 272622002318 putative AMP binding site [chemical binding]; other site 272622002319 putative active site [active] 272622002320 putative CoA binding site [chemical binding]; other site 272622002321 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 272622002322 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 272622002323 substrate binding site [chemical binding]; other site 272622002324 oxyanion hole (OAH) forming residues; other site 272622002325 trimer interface [polypeptide binding]; other site 272622002326 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 272622002327 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 272622002328 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase [Coenzyme metabolism]; Region: MenD; COG1165 272622002329 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 272622002330 dimer interface [polypeptide binding]; other site 272622002331 tetramer interface [polypeptide binding]; other site 272622002332 PYR/PP interface [polypeptide binding]; other site 272622002333 TPP binding site [chemical binding]; other site 272622002334 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 272622002335 TPP-binding site; other site 272622002336 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 272622002337 chorismate binding enzyme; Region: Chorismate_bind; cl10555 272622002338 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 272622002339 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 272622002340 DRTGG domain; Region: DRTGG; pfam07085 272622002341 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 272622002342 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 272622002343 DHH family; Region: DHH; pfam01368 272622002344 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 272622002345 active site 272622002346 homotetramer interface [polypeptide binding]; other site 272622002347 homodimer interface [polypeptide binding]; other site 272622002348 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 272622002349 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272622002350 active site 272622002351 motif I; other site 272622002352 motif II; other site 272622002353 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 272622002354 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4696 272622002355 metal binding site [ion binding]; metal-binding site 272622002356 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 272622002357 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 272622002358 aspartate kinase; Reviewed; Region: PRK09034 272622002359 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 272622002360 nucleotide binding site [chemical binding]; other site 272622002361 substrate binding site [chemical binding]; other site 272622002362 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 272622002363 allosteric regulatory residue; other site 272622002364 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 272622002365 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 272622002366 active site 272622002367 nucleophile elbow; other site 272622002368 Transcriptional regulators [Transcription]; Region: MarR; COG1846 272622002369 MarR family; Region: MarR_2; pfam12802 272622002370 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 272622002371 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272622002372 motif II; other site 272622002373 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 272622002374 DHH family; Region: DHH; pfam01368 272622002375 DHHA1 domain; Region: DHHA1; pfam02272 272622002376 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 272622002377 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 272622002378 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 272622002379 replicative DNA helicase; Provisional; Region: PRK05748 272622002380 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 272622002381 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 272622002382 Walker A motif; other site 272622002383 ATP binding site [chemical binding]; other site 272622002384 Walker B motif; other site 272622002385 DNA binding loops [nucleotide binding] 272622002386 Uncharacterized protein conserved in bacteria [Function unknown]; Region: Veg; COG4466 272622002387 Thiamine kinase and related kinases [Coenzyme transport and metabolism]; Region: ycfN; COG0510 272622002388 Phosphotransferase enzyme family; Region: APH; pfam01636 272622002389 active site 272622002390 ATP binding site [chemical binding]; other site 272622002391 substrate binding site [chemical binding]; other site 272622002392 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272622002393 S-adenosylmethionine binding site [chemical binding]; other site 272622002394 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 272622002395 Transcription factor S-II (TFIIS); Region: TFIIS_C; cl02609 272622002396 ATP cone domain; Region: ATP-cone; pfam03477 272622002397 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 272622002398 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 272622002399 primosomal protein DnaI; Reviewed; Region: PRK08939 272622002400 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 272622002401 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272622002402 Walker A motif; other site 272622002403 ATP binding site [chemical binding]; other site 272622002404 Walker B motif; other site 272622002405 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 272622002406 dimer interface [polypeptide binding]; other site 272622002407 FMN binding site [chemical binding]; other site 272622002408 NADPH bind site [chemical binding]; other site 272622002409 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 272622002410 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 272622002411 GTP-binding protein Der; Reviewed; Region: PRK00093 272622002412 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 272622002413 G1 box; other site 272622002414 GTP/Mg2+ binding site [chemical binding]; other site 272622002415 Switch I region; other site 272622002416 G2 box; other site 272622002417 Switch II region; other site 272622002418 G3 box; other site 272622002419 G4 box; other site 272622002420 G5 box; other site 272622002421 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 272622002422 G1 box; other site 272622002423 GTP/Mg2+ binding site [chemical binding]; other site 272622002424 Switch I region; other site 272622002425 G2 box; other site 272622002426 G3 box; other site 272622002427 Switch II region; other site 272622002428 G4 box; other site 272622002429 G5 box; other site 272622002430 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 272622002431 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272622002432 non-specific DNA binding site [nucleotide binding]; other site 272622002433 salt bridge; other site 272622002434 sequence-specific DNA binding site [nucleotide binding]; other site 272622002435 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 272622002436 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 272622002437 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 272622002438 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 272622002439 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 272622002440 active site 272622002441 catalytic site [active] 272622002442 Protein of unknown function (DUF3990); Region: DUF3990; pfam13151 272622002443 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 272622002444 Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380 272622002445 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG0779 272622002446 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 272622002447 putative oligomer interface [polypeptide binding]; other site 272622002448 putative RNA binding site [nucleotide binding]; other site 272622002449 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 272622002450 NusA N-terminal domain; Region: NusA_N; pfam08529 272622002451 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 272622002452 RNA binding site [nucleotide binding]; other site 272622002453 homodimer interface [polypeptide binding]; other site 272622002454 NusA-like KH domain; Region: KH_5; pfam13184 272622002455 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 272622002456 G-X-X-G motif; other site 272622002457 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 272622002458 putative RNA binding cleft [nucleotide binding]; other site 272622002459 hypothetical protein; Provisional; Region: PRK07283 272622002460 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 272622002461 translation initiation factor IF-2; Region: IF-2; TIGR00487 272622002462 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 272622002463 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 272622002464 G1 box; other site 272622002465 putative GEF interaction site [polypeptide binding]; other site 272622002466 GTP/Mg2+ binding site [chemical binding]; other site 272622002467 Switch I region; other site 272622002468 G2 box; other site 272622002469 G3 box; other site 272622002470 Switch II region; other site 272622002471 G4 box; other site 272622002472 G5 box; other site 272622002473 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 272622002474 Translation-initiation factor 2; Region: IF-2; pfam11987 272622002475 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 272622002476 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 272622002477 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 272622002478 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 272622002479 MarR family; Region: MarR; pfam01047 272622002480 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 272622002481 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 272622002482 dimer interface [polypeptide binding]; other site 272622002483 active site 272622002484 CoA binding pocket [chemical binding]; other site 272622002485 acyl carrier protein; Provisional; Region: acpP; PRK00982 272622002486 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 272622002487 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 272622002488 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 272622002489 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 272622002490 NAD(P) binding site [chemical binding]; other site 272622002491 homotetramer interface [polypeptide binding]; other site 272622002492 homodimer interface [polypeptide binding]; other site 272622002493 active site 272622002494 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 272622002495 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 272622002496 dimer interface [polypeptide binding]; other site 272622002497 active site 272622002498 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 272622002499 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 272622002500 carboxyltransferase (CT) interaction site; other site 272622002501 biotinylation site [posttranslational modification]; other site 272622002502 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 272622002503 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 272622002504 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 272622002505 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 272622002506 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 272622002507 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 272622002508 DNA directed RNA polymerase, 7 kDa subunit; Region: DNA_RNApol_7kD; cl00874 272622002509 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 272622002510 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; COG0825 272622002511 cystathionine gamma-synthase/cystathionine beta-lyase; Validated; Region: PRK06176 272622002512 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 272622002513 homodimer interface [polypeptide binding]; other site 272622002514 substrate-cofactor binding pocket; other site 272622002515 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272622002516 catalytic residue [active] 272622002517 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 272622002518 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 272622002519 dimer interface [polypeptide binding]; other site 272622002520 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272622002521 catalytic residue [active] 272622002522 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237 272622002523 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 272622002524 active site residue [active] 272622002525 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 272622002526 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 272622002527 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 272622002528 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 272622002529 Member of the Rhodanese Homology Domain superfamily. Included in this CD are the Lactococcus lactis NADH oxidase, Bacillus cereus NADH dehydrogenase, and Bacteroides thetaiotaomicron pyridine nucleotide-disulphide oxidoreductase, and similar...; Region: RHOD_Pyr_redox; cd01524 272622002530 active site residue [active] 272622002531 Uncharacterized protein YrkD from Bacillus subtilis and related domains; this domain superfamily was previously known as part of DUF156; Region: BsYrkD-like_DUF156; cd10155 272622002532 putative homodimer interface [polypeptide binding]; other site 272622002533 putative homotetramer interface [polypeptide binding]; other site 272622002534 putative metal binding site [ion binding]; other site 272622002535 putative homodimer-homodimer interface [polypeptide binding]; other site 272622002536 putative allosteric switch controlling residues; other site 272622002537 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 272622002538 ArsC family; Region: ArsC; pfam03960 272622002539 putative ArsC-like catalytic residues; other site 272622002540 putative TRX-like catalytic residues [active] 272622002541 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 272622002542 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 272622002543 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 272622002544 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 272622002545 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 272622002546 active site 272622002547 putative catalytic site [active] 272622002548 DNA binding site [nucleotide binding] 272622002549 putative phosphate binding site [ion binding]; other site 272622002550 metal binding site A [ion binding]; metal-binding site 272622002551 AP binding site [nucleotide binding]; other site 272622002552 metal binding site B [ion binding]; metal-binding site 272622002553 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 272622002554 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 272622002555 active site 272622002556 HIGH motif; other site 272622002557 KMSKS motif; other site 272622002558 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 272622002559 tRNA binding surface [nucleotide binding]; other site 272622002560 anticodon binding site; other site 272622002561 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 272622002562 dimer interface [polypeptide binding]; other site 272622002563 putative tRNA-binding site [nucleotide binding]; other site 272622002564 Protein of unknown function (DUF2829); Region: DUF2829; pfam11195 272622002565 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK06550 272622002566 classical (c) SDRs; Region: SDR_c; cd05233 272622002567 NAD(P) binding site [chemical binding]; other site 272622002568 active site 272622002569 Predicted membrane protein [Function unknown]; Region: COG4708 272622002570 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 272622002571 NADH(P)-binding; Region: NAD_binding_10; pfam13460 272622002572 NAD binding site [chemical binding]; other site 272622002573 substrate binding site [chemical binding]; other site 272622002574 putative active site [active] 272622002575 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 272622002576 Transposase; Region: HTH_Tnp_1; pfam01527 272622002577 putative transposase OrfB; Reviewed; Region: PHA02517 272622002578 HTH-like domain; Region: HTH_21; pfam13276 272622002579 Integrase core domain; Region: rve; pfam00665 272622002580 Integrase core domain; Region: rve_3; pfam13683 272622002581 HTH-like domain; Region: HTH_21; pfam13276 272622002582 Integrase core domain; Region: rve; pfam00665 272622002583 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 272622002584 Helix-turn-helix domain; Region: HTH_28; pfam13518 272622002585 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 272622002586 Transposase; Region: HTH_Tnp_1; cl17663 272622002587 putative transposase OrfB; Reviewed; Region: PHA02517 272622002588 HTH-like domain; Region: HTH_21; pfam13276 272622002589 Integrase core domain; Region: rve; pfam00665 272622002590 Integrase core domain; Region: rve_3; pfam13683 272622002591 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 272622002592 Transposase; Region: HTH_Tnp_1; pfam01527 272622002593 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 272622002594 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 272622002595 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 272622002596 heterotetramer interface [polypeptide binding]; other site 272622002597 active site pocket [active] 272622002598 cleavage site 272622002599 acetylornithine aminotransferase; Provisional; Region: argD; PRK02936 272622002600 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 272622002601 inhibitor-cofactor binding pocket; inhibition site 272622002602 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272622002603 catalytic residue [active] 272622002604 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 272622002605 feedback inhibition sensing region; other site 272622002606 homohexameric interface [polypeptide binding]; other site 272622002607 nucleotide binding site [chemical binding]; other site 272622002608 N-acetyl-L-glutamate binding site [chemical binding]; other site 272622002609 ornithine carbamoyltransferase; Validated; Region: PRK02102 272622002610 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 272622002611 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 272622002612 ribonuclease III; Reviewed; Region: rnc; PRK00102 272622002613 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 272622002614 dimerization interface [polypeptide binding]; other site 272622002615 active site 272622002616 metal binding site [ion binding]; metal-binding site 272622002617 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 272622002618 dsRNA binding site [nucleotide binding]; other site 272622002619 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 272622002620 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 272622002621 Walker A/P-loop; other site 272622002622 ATP binding site [chemical binding]; other site 272622002623 Q-loop/lid; other site 272622002624 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 272622002625 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 272622002626 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 272622002627 Q-loop/lid; other site 272622002628 ABC transporter signature motif; other site 272622002629 Walker B; other site 272622002630 D-loop; other site 272622002631 H-loop/switch region; other site 272622002632 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 272622002633 Sulfatase; Region: Sulfatase; cl17466 272622002634 Predicted multitransmembrane protein [Function unknown]; Region: COG5438 272622002635 Predicted multitransmembrane protein [Function unknown]; Region: COG5438 272622002636 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 272622002637 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272622002638 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 272622002639 active site 272622002640 motif I; other site 272622002641 motif II; other site 272622002642 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 272622002643 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 272622002644 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02269 272622002645 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 272622002646 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 272622002647 active site 272622002648 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 272622002649 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 272622002650 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 272622002651 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 272622002652 HIGH motif; other site 272622002653 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 272622002654 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 272622002655 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 272622002656 active site 272622002657 KMSKS motif; other site 272622002658 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 272622002659 tRNA binding surface [nucleotide binding]; other site 272622002660 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 272622002661 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 272622002662 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 272622002663 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 272622002664 putative active site [active] 272622002665 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 272622002666 beta-galactosidase; Region: BGL; TIGR03356 272622002667 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 272622002668 Lipase (class 2); Region: Lipase_2; pfam01674 272622002669 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 272622002670 nucleophilic elbow; other site 272622002671 catalytic triad; other site 272622002672 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 272622002673 Helix-turn-helix domain; Region: HTH_28; pfam13518 272622002674 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 272622002675 Homeodomain-like domain; Region: HTH_23; cl17451 272622002676 putative transposase OrfB; Reviewed; Region: PHA02517 272622002677 HTH-like domain; Region: HTH_21; pfam13276 272622002678 Integrase core domain; Region: rve; pfam00665 272622002679 Integrase core domain; Region: rve_2; pfam13333 272622002680 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 272622002681 Transposase; Region: HTH_Tnp_1; pfam01527 272622002682 putative transposase OrfB; Reviewed; Region: PHA02517 272622002683 HTH-like domain; Region: HTH_21; pfam13276 272622002684 Integrase core domain; Region: rve; pfam00665 272622002685 Integrase core domain; Region: rve_3; pfam13683 272622002686 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 272622002687 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 272622002688 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 272622002689 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 272622002690 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 272622002691 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 272622002692 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 272622002693 putative L-serine binding site [chemical binding]; other site 272622002694 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 272622002695 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 272622002696 Predicted transcriptional regulator [Transcription]; Region: COG3682 272622002697 copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698 272622002698 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 272622002699 metal-binding site [ion binding] 272622002700 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 272622002701 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 272622002702 metal-binding site [ion binding] 272622002703 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 272622002704 Predicted membrane protein [Function unknown]; Region: COG4485 272622002705 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 272622002706 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 272622002707 nucleotide binding site/active site [active] 272622002708 HIT family signature motif; other site 272622002709 catalytic residue [active] 272622002710 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 272622002711 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 272622002712 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 272622002713 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 272622002714 RNA binding site [nucleotide binding]; other site 272622002715 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 272622002716 RNA binding site [nucleotide binding]; other site 272622002717 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 272622002718 RNA binding site [nucleotide binding]; other site 272622002719 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 272622002720 RNA binding site [nucleotide binding]; other site 272622002721 Fibronectin-binding repeat; Region: SSURE; pfam11966 272622002722 Fibronectin-binding repeat; Region: SSURE; pfam11966 272622002723 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 272622002724 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272622002725 active site 272622002726 phosphorylation site [posttranslational modification] 272622002727 intermolecular recognition site; other site 272622002728 dimerization interface [polypeptide binding]; other site 272622002729 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272622002730 DNA binding site [nucleotide binding] 272622002731 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272622002732 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272622002733 dimer interface [polypeptide binding]; other site 272622002734 phosphorylation site [posttranslational modification] 272622002735 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272622002736 ATP binding site [chemical binding]; other site 272622002737 Mg2+ binding site [ion binding]; other site 272622002738 G-X-G motif; other site 272622002739 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 272622002740 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 272622002741 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 272622002742 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 272622002743 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 272622002744 GIY-YIG motif/motif A; other site 272622002745 active site 272622002746 catalytic site [active] 272622002747 putative DNA binding site [nucleotide binding]; other site 272622002748 metal binding site [ion binding]; metal-binding site 272622002749 UvrB/uvrC motif; Region: UVR; pfam02151 272622002750 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 272622002751 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 272622002752 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 272622002753 minor groove reading motif; other site 272622002754 helix-hairpin-helix signature motif; other site 272622002755 substrate binding pocket [chemical binding]; other site 272622002756 active site 272622002757 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 272622002758 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 272622002759 DNA binding and oxoG recognition site [nucleotide binding] 272622002760 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272622002761 sequence-specific DNA binding site [nucleotide binding]; other site 272622002762 salt bridge; other site 272622002763 putative transposase OrfB; Reviewed; Region: PHA02517 272622002764 HTH-like domain; Region: HTH_21; pfam13276 272622002765 Integrase core domain; Region: rve; pfam00665 272622002766 Integrase core domain; Region: rve_3; pfam13683 272622002767 glycosyltransferase, SP_1767 family; Region: glyco_access_1; TIGR03728 272622002768 dipeptidase PepV; Region: dipeptidase; TIGR01886 272622002769 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 272622002770 active site 272622002771 metal binding site [ion binding]; metal-binding site 272622002772 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 272622002773 alanine racemase; Reviewed; Region: alr; PRK00053 272622002774 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 272622002775 active site 272622002776 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 272622002777 dimer interface [polypeptide binding]; other site 272622002778 substrate binding site [chemical binding]; other site 272622002779 catalytic residues [active] 272622002780 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 272622002781 ArsC family; Region: ArsC; pfam03960 272622002782 putative catalytic residues [active] 272622002783 thiol/disulfide switch; other site 272622002784 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 272622002785 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 272622002786 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 272622002787 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 272622002788 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272622002789 Walker A/P-loop; other site 272622002790 ATP binding site [chemical binding]; other site 272622002791 Q-loop/lid; other site 272622002792 ABC transporter signature motif; other site 272622002793 Walker B; other site 272622002794 D-loop; other site 272622002795 H-loop/switch region; other site 272622002796 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272622002797 ABC-ATPase subunit interface; other site 272622002798 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 272622002799 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 272622002800 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 272622002801 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 272622002802 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 272622002803 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 272622002804 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 272622002805 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14179 272622002806 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 272622002807 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 272622002808 homodimer interface [polypeptide binding]; other site 272622002809 NADP binding site [chemical binding]; other site 272622002810 substrate binding site [chemical binding]; other site 272622002811 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 272622002812 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 272622002813 generic binding surface II; other site 272622002814 generic binding surface I; other site 272622002815 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 272622002816 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 272622002817 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 272622002818 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 272622002819 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 272622002820 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 272622002821 substrate binding pocket [chemical binding]; other site 272622002822 chain length determination region; other site 272622002823 substrate-Mg2+ binding site; other site 272622002824 catalytic residues [active] 272622002825 aspartate-rich region 1; other site 272622002826 active site lid residues [active] 272622002827 aspartate-rich region 2; other site 272622002828 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 272622002829 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272622002830 Coenzyme A binding pocket [chemical binding]; other site 272622002831 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 272622002832 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 272622002833 RNA binding surface [nucleotide binding]; other site 272622002834 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 272622002835 Arginine repressor [Transcription]; Region: ArgR; COG1438 272622002836 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 272622002837 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 272622002838 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 272622002839 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 272622002840 Walker A/P-loop; other site 272622002841 ATP binding site [chemical binding]; other site 272622002842 Q-loop/lid; other site 272622002843 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 272622002844 ABC transporter signature motif; other site 272622002845 Walker B; other site 272622002846 D-loop; other site 272622002847 H-loop/switch region; other site 272622002848 Predicted integral membrane protein [Function unknown]; Region: COG3548 272622002849 Predicted membrane protein [Function unknown]; Region: COG3152 272622002850 Protein of unknown function (DUF805); Region: DUF805; pfam05656 272622002851 Protein of unknown function (DUF805); Region: DUF805; cl01224 272622002852 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 272622002853 MraW methylase family; Region: Methyltransf_5; pfam01795 272622002854 Protein required for the initiation of cell division [Cell division and chromosome partitioning]; Region: FtsL; COG4839 272622002855 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 272622002856 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 272622002857 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 272622002858 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 272622002859 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 272622002860 phospho-N-acetylmuramoyl-pentapeptide-transferase; Region: mraY; TIGR00445 272622002861 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 272622002862 Mg++ binding site [ion binding]; other site 272622002863 putative catalytic motif [active] 272622002864 putative substrate binding site [chemical binding]; other site 272622002865 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 272622002866 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 272622002867 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 272622002868 Walker A/P-loop; other site 272622002869 ATP binding site [chemical binding]; other site 272622002870 Q-loop/lid; other site 272622002871 ABC transporter signature motif; other site 272622002872 Walker B; other site 272622002873 D-loop; other site 272622002874 H-loop/switch region; other site 272622002875 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272622002876 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272622002877 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 272622002878 dimerization interface [polypeptide binding]; other site 272622002879 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 272622002880 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 272622002881 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 272622002882 synthetase active site [active] 272622002883 NTP binding site [chemical binding]; other site 272622002884 metal binding site [ion binding]; metal-binding site 272622002885 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 272622002886 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 272622002887 SnoaL-like domain; Region: SnoaL_3; pfam13474 272622002888 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272622002889 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 272622002890 Coenzyme A binding pocket [chemical binding]; other site 272622002891 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 272622002892 N-glycosyltransferase; Provisional; Region: PRK11204 272622002893 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 272622002894 DXD motif; other site 272622002895 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 272622002896 nicotinamide mononucleotide transporter PnuC; Region: NMN_trans_PnuC; TIGR01528 272622002897 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 272622002898 Ligand Binding Site [chemical binding]; other site 272622002899 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 272622002900 IHF - DNA interface [nucleotide binding]; other site 272622002901 IHF dimer interface [polypeptide binding]; other site 272622002902 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 272622002903 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 272622002904 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 272622002905 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 272622002906 Predicted membrane protein [Function unknown]; Region: COG1511 272622002907 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 272622002908 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 272622002909 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 272622002910 Integrase core domain; Region: rve; pfam00665 272622002911 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 272622002912 Transposase; Region: HTH_Tnp_1; pfam01527 272622002913 putative transposase OrfB; Reviewed; Region: PHA02517 272622002914 HTH-like domain; Region: HTH_21; pfam13276 272622002915 Integrase core domain; Region: rve; pfam00665 272622002916 Integrase core domain; Region: rve_3; pfam13683 272622002917 Predicted membrane protein [Function unknown]; Region: COG4758 272622002918 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 272622002919 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272622002920 Histidine kinase; Region: HisKA_3; pfam07730 272622002921 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272622002922 ATP binding site [chemical binding]; other site 272622002923 Mg2+ binding site [ion binding]; other site 272622002924 G-X-G motif; other site 272622002925 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 272622002926 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272622002927 active site 272622002928 phosphorylation site [posttranslational modification] 272622002929 intermolecular recognition site; other site 272622002930 dimerization interface [polypeptide binding]; other site 272622002931 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 272622002932 DNA binding residues [nucleotide binding] 272622002933 dimerization interface [polypeptide binding]; other site 272622002934 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 272622002935 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 272622002936 motif II; other site 272622002937 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 272622002938 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 272622002939 active site 272622002940 Predicted RNA binding protein (contains ribosomal protein S1 domain) [Translation, ribosomal structure and biogenesis]; Region: VacB; COG1098 272622002941 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 272622002942 RNA binding site [nucleotide binding]; other site 272622002943 Uncharacterized conserved protein [Function unknown]; Region: COG0398 272622002944 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 272622002945 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 272622002946 acetoin reductase; Validated; Region: PRK08643 272622002947 meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366 272622002948 NAD binding site [chemical binding]; other site 272622002949 homotetramer interface [polypeptide binding]; other site 272622002950 homodimer interface [polypeptide binding]; other site 272622002951 active site 272622002952 substrate binding site [chemical binding]; other site 272622002953 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 272622002954 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 272622002955 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 272622002956 ABC transporter; Region: ABC_tran_2; pfam12848 272622002957 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 272622002958 2-hydroxycarboxylate transporter family; Region: 2HCT; cl01386 272622002959 EamA-like transporter family; Region: EamA; pfam00892 272622002960 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 272622002961 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 272622002962 putative metal binding site [ion binding]; other site 272622002963 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 272622002964 active site 272622002965 metal binding site [ion binding]; metal-binding site 272622002966 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 272622002967 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272622002968 motif II; other site 272622002969 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 272622002970 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272622002971 Mg2+ binding site [ion binding]; other site 272622002972 G-X-G motif; other site 272622002973 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 272622002974 anchoring element; other site 272622002975 dimer interface [polypeptide binding]; other site 272622002976 ATP binding site [chemical binding]; other site 272622002977 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 272622002978 active site 272622002979 putative metal-binding site [ion binding]; other site 272622002980 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 272622002981 Transposase, Mutator family; Region: Transposase_mut; pfam00872 272622002982 MULE transposase domain; Region: MULE; pfam10551 272622002983 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 272622002984 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 272622002985 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 272622002986 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 272622002987 Transposase; Region: HTH_Tnp_1; pfam01527 272622002988 putative transposase OrfB; Reviewed; Region: PHA02517 272622002989 HTH-like domain; Region: HTH_21; pfam13276 272622002990 Integrase core domain; Region: rve; pfam00665 272622002991 Integrase core domain; Region: rve_3; pfam13683 272622002992 Domain of unknown function (DUF4422); Region: DUF4422; pfam14393 272622002993 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 272622002994 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 272622002995 active site 272622002996 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 272622002997 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 272622002998 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 272622002999 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 272622003000 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 272622003001 Transcriptional regulator [Transcription]; Region: LytR; COG1316 272622003002 phosphopentomutase; Provisional; Region: PRK05362 272622003003 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 272622003004 Putative zinc ribbon domain; Region: Zn_ribbon_2; pfam12674 272622003005 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 272622003006 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 272622003007 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 272622003008 hypothetical protein; Provisional; Region: PRK00967 272622003009 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 272622003010 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 272622003011 Potassium binding sites [ion binding]; other site 272622003012 Cesium cation binding sites [ion binding]; other site 272622003013 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 272622003014 NlpC/P60 family; Region: NLPC_P60; pfam00877 272622003015 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 272622003016 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 272622003017 substrate binding pocket [chemical binding]; other site 272622003018 membrane-bound complex binding site; other site 272622003019 hinge residues; other site 272622003020 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272622003021 dimer interface [polypeptide binding]; other site 272622003022 conserved gate region; other site 272622003023 putative PBP binding loops; other site 272622003024 ABC-ATPase subunit interface; other site 272622003025 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 272622003026 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 272622003027 Walker A/P-loop; other site 272622003028 ATP binding site [chemical binding]; other site 272622003029 Q-loop/lid; other site 272622003030 ABC transporter signature motif; other site 272622003031 Walker B; other site 272622003032 D-loop; other site 272622003033 H-loop/switch region; other site 272622003034 Protein of unknown function (DUF4059); Region: DUF4059; pfam13268 272622003035 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 272622003036 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 272622003037 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 272622003038 Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314 272622003039 ribonuclease R; Region: RNase_R; TIGR02063 272622003040 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 272622003041 RNB domain; Region: RNB; pfam00773 272622003042 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 272622003043 RNA binding site [nucleotide binding]; other site 272622003044 Isochorismatase family; Region: Isochorismatase; pfam00857 272622003045 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 272622003046 catalytic triad [active] 272622003047 conserved cis-peptide bond; other site 272622003048 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 272622003049 putative catalytic site [active] 272622003050 putative metal binding site [ion binding]; other site 272622003051 putative phosphate binding site [ion binding]; other site 272622003052 1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; COG1575 272622003053 UbiA prenyltransferase family; Region: UbiA; pfam01040 272622003054 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 272622003055 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 272622003056 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 272622003057 catalytic core [active] 272622003058 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 272622003059 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 272622003060 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 272622003061 Transcriptional regulator of heat shock gene [Transcription]; Region: HrcA; COG1420 272622003062 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 272622003063 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 272622003064 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 272622003065 dimer interface [polypeptide binding]; other site 272622003066 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 272622003067 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 272622003068 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 272622003069 nucleotide binding site [chemical binding]; other site 272622003070 NEF interaction site [polypeptide binding]; other site 272622003071 SBD interface [polypeptide binding]; other site 272622003072 6-pyruvoyl-tetrahydropterin synthase related domain; membrane protein; Region: PTPS_related; pfam10131 272622003073 Myosin-crossreactive antigen [Function unknown]; Region: COG4716 272622003074 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 272622003075 M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669 272622003076 metal binding site [ion binding]; metal-binding site 272622003077 dimer interface [polypeptide binding]; other site 272622003078 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 272622003079 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 272622003080 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 272622003081 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 272622003082 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 272622003083 putative substrate binding site [chemical binding]; other site 272622003084 putative ATP binding site [chemical binding]; other site 272622003085 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 272622003086 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 272622003087 active site 272622003088 phosphorylation site [posttranslational modification] 272622003089 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 272622003090 active site 272622003091 P-loop; other site 272622003092 phosphorylation site [posttranslational modification] 272622003093 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 272622003094 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 272622003095 Helix-turn-helix domain; Region: HTH_28; pfam13518 272622003096 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 272622003097 Homeodomain-like domain; Region: HTH_23; cl17451 272622003098 putative transposase OrfB; Reviewed; Region: PHA02517 272622003099 HTH-like domain; Region: HTH_21; pfam13276 272622003100 Integrase core domain; Region: rve; pfam00665 272622003101 Integrase core domain; Region: rve_2; pfam13333 272622003102 putative transposase OrfB; Reviewed; Region: PHA02517 272622003103 HTH-like domain; Region: HTH_21; pfam13276 272622003104 Integrase core domain; Region: rve; pfam00665 272622003105 Integrase core domain; Region: rve_3; pfam13683 272622003106 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 272622003107 Transposase; Region: HTH_Tnp_1; pfam01527 272622003108 Protein of unknown function (DUF805); Region: DUF805; pfam05656 272622003109 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 272622003110 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 272622003111 Soluble P-type ATPase [General function prediction only]; Region: COG4087 272622003112 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 272622003113 metal-binding site [ion binding] 272622003114 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 272622003115 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 272622003116 ligand binding site [chemical binding]; other site 272622003117 flexible hinge region; other site 272622003118 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 272622003119 putative switch regulator; other site 272622003120 non-specific DNA interactions [nucleotide binding]; other site 272622003121 DNA binding site [nucleotide binding] 272622003122 sequence specific DNA binding site [nucleotide binding]; other site 272622003123 putative cAMP binding site [chemical binding]; other site 272622003124 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 272622003125 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 272622003126 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 272622003127 putative active site [active] 272622003128 catalytic site [active] 272622003129 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 272622003130 putative active site [active] 272622003131 catalytic site [active] 272622003132 Predicted P-loop-containing kinase [General function prediction only]; Region: COG1660 272622003133 AAA domain; Region: AAA_18; pfam13238 272622003134 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 272622003135 Family of CofD-like proteins and proteins related to YvcK; Region: CofD_YvcK; cd07044 272622003136 dimer interface [polypeptide binding]; other site 272622003137 phosphate binding site [ion binding]; other site 272622003138 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 272622003139 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 272622003140 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 272622003141 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 272622003142 Walker A/P-loop; other site 272622003143 ATP binding site [chemical binding]; other site 272622003144 Q-loop/lid; other site 272622003145 ABC transporter signature motif; other site 272622003146 Walker B; other site 272622003147 D-loop; other site 272622003148 H-loop/switch region; other site 272622003149 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 272622003150 Transposase, Mutator family; Region: Transposase_mut; pfam00872 272622003151 MULE transposase domain; Region: MULE; pfam10551 272622003152 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 272622003153 hypothetical protein; Provisional; Region: PRK13662 272622003154 putative phosphoesterase; Region: acc_ester; TIGR03729 272622003155 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 272622003156 peptide chain release factor 2; Validated; Region: prfB; PRK00578 272622003157 This domain is found in peptide chain release factors; Region: PCRF; smart00937 272622003158 RF-1 domain; Region: RF-1; pfam00472 272622003159 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 272622003160 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272622003161 Walker A/P-loop; other site 272622003162 ATP binding site [chemical binding]; other site 272622003163 Q-loop/lid; other site 272622003164 ABC transporter signature motif; other site 272622003165 Walker B; other site 272622003166 D-loop; other site 272622003167 H-loop/switch region; other site 272622003168 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 272622003169 FtsX-like permease family; Region: FtsX; pfam02687 272622003170 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 272622003171 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 272622003172 dimer interface [polypeptide binding]; other site 272622003173 putative radical transfer pathway; other site 272622003174 diiron center [ion binding]; other site 272622003175 tyrosyl radical; other site 272622003176 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07306 272622003177 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 272622003178 Class I ribonucleotide reductase; Region: RNR_I; cd01679 272622003179 active site 272622003180 dimer interface [polypeptide binding]; other site 272622003181 catalytic residues [active] 272622003182 effector binding site; other site 272622003183 R2 peptide binding site; other site 272622003184 Protein involved in ribonucleotide reduction [Nucleotide transport and metabolism]; Region: NrdI; COG1780 272622003185 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 272622003186 catalytic residues [active] 272622003187 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 272622003188 DNA topoisomerase IV, B subunit, Gram-positive; Region: parE_Gpos; TIGR01058 272622003189 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272622003190 Mg2+ binding site [ion binding]; other site 272622003191 G-X-G motif; other site 272622003192 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 272622003193 anchoring element; other site 272622003194 dimer interface [polypeptide binding]; other site 272622003195 ATP binding site [chemical binding]; other site 272622003196 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 272622003197 active site 272622003198 putative metal-binding site [ion binding]; other site 272622003199 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 272622003200 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 272622003201 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 272622003202 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 272622003203 active site 272622003204 catalytic site [active] 272622003205 substrate binding site [chemical binding]; other site 272622003206 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272622003207 Coenzyme A binding pocket [chemical binding]; other site 272622003208 DNA topoisomerase IV, A subunit, Gram-positive; Region: parC_Gpos; TIGR01061 272622003209 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 272622003210 CAP-like domain; other site 272622003211 active site 272622003212 primary dimer interface [polypeptide binding]; other site 272622003213 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 272622003214 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 272622003215 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 272622003216 oligomer interface [polypeptide binding]; other site 272622003217 Cl binding site [ion binding]; other site 272622003218 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 272622003219 Lumazine binding domain; Region: Lum_binding; pfam00677 272622003220 Lumazine binding domain; Region: Lum_binding; pfam00677 272622003221 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 272622003222 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 272622003223 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 272622003224 dimerization interface [polypeptide binding]; other site 272622003225 active site 272622003226 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 272622003227 homopentamer interface [polypeptide binding]; other site 272622003228 active site 272622003229 HTH domain; Region: HTH_11; pfam08279 272622003230 Transposase, Mutator family; Region: Transposase_mut; pfam00872 272622003231 MULE transposase domain; Region: MULE; pfam10551 272622003232 lipoprotein signal peptidase; Provisional; Region: PRK14797 272622003233 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 272622003234 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 272622003235 RNA binding surface [nucleotide binding]; other site 272622003236 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 272622003237 active site 272622003238 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 272622003239 active site 272622003240 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 272622003241 Helix-turn-helix domain; Region: HTH_28; pfam13518 272622003242 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 272622003243 Homeodomain-like domain; Region: HTH_23; cl17451 272622003244 putative transposase OrfB; Reviewed; Region: PHA02517 272622003245 HTH-like domain; Region: HTH_21; pfam13276 272622003246 Integrase core domain; Region: rve; pfam00665 272622003247 Integrase core domain; Region: rve_2; pfam13333 272622003248 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 272622003249 Transposase; Region: HTH_Tnp_1; pfam01527 272622003250 putative transposase OrfB; Reviewed; Region: PHA02517 272622003251 HTH-like domain; Region: HTH_21; pfam13276 272622003252 Integrase core domain; Region: rve; pfam00665 272622003253 Integrase core domain; Region: rve_3; pfam13683 272622003254 conserved hypothetical integral membrane protein; Region: TIGR03766 272622003255 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 272622003256 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 272622003257 Ligand binding site; other site 272622003258 Putative Catalytic site; other site 272622003259 DXD motif; other site 272622003260 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 272622003261 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272622003262 active site 272622003263 phosphorylation site [posttranslational modification] 272622003264 intermolecular recognition site; other site 272622003265 dimerization interface [polypeptide binding]; other site 272622003266 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272622003267 DNA binding site [nucleotide binding] 272622003268 Predicted membrane protein (DUF2127); Region: DUF2127; cl01785 272622003269 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 272622003270 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272622003271 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272622003272 dimer interface [polypeptide binding]; other site 272622003273 phosphorylation site [posttranslational modification] 272622003274 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272622003275 ATP binding site [chemical binding]; other site 272622003276 Mg2+ binding site [ion binding]; other site 272622003277 G-X-G motif; other site 272622003278 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 272622003279 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 272622003280 active site 272622003281 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 272622003282 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 272622003283 glutaminase active site [active] 272622003284 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 272622003285 dimer interface [polypeptide binding]; other site 272622003286 active site 272622003287 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 272622003288 dimer interface [polypeptide binding]; other site 272622003289 active site 272622003290 DNA repair protein radc; Region: radc; TIGR00608 272622003291 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 272622003292 MPN+ (JAMM) motif; other site 272622003293 Zinc-binding site [ion binding]; other site 272622003294 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 272622003295 Int/Topo IB signature motif; other site 272622003296 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 272622003297 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272622003298 non-specific DNA binding site [nucleotide binding]; other site 272622003299 salt bridge; other site 272622003300 sequence-specific DNA binding site [nucleotide binding]; other site 272622003301 Lactococcus bacteriophage repressor; Region: Lac_bphage_repr; pfam06543 272622003302 ORF6N domain; Region: ORF6N; pfam10543 272622003303 ORF6C domain; Region: ORF6C; pfam10552 272622003304 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4707 272622003305 ERF superfamily; Region: ERF; pfam04404 272622003306 replication factor A; Provisional; Region: PRK07218 272622003307 Helix-turn-helix domain; Region: HTH_36; pfam13730 272622003308 Holliday junction resolvase [DNA replication, recombination, and repair]; Region: Rus; COG4570 272622003309 Protein of unknown function (DUF1031); Region: DUF1031; pfam06275 272622003310 Protein of unknown function (DUF1497); Region: DUF1497; pfam07384 272622003311 Protein of unknown function (DUF658); Region: DUF658; pfam04936 272622003312 Protein of unknown function (DUF1642); Region: DUF1642; pfam07852 272622003313 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 272622003314 trimer interface [polypeptide binding]; other site 272622003315 active site 272622003316 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 272622003317 Prophage protein (DUF1660); Region: DUF1660; pfam07874 272622003318 Protein of unknown function (DUF722); Region: DUF722; pfam05263 272622003319 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5410 272622003320 Terminase-like family; Region: Terminase_6; pfam03237 272622003321 Phage-related terminase [General function prediction only]; Region: COG5362; cl02216 272622003322 phage portal protein, SPP1 family; Region: portal_SPP1; TIGR01538 272622003323 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 272622003324 phage putative head morphogenesis protein, SPP1 gp7 family; Region: phageSPP1_gp7; TIGR01641 272622003325 Domain of unknown function (DUF4355); Region: DUF4355; pfam14265 272622003326 Phage capsid family; Region: Phage_capsid; pfam05065 272622003327 HeH/LEM domain; Region: HeH; pfam12949 272622003328 Phage gp6-like head-tail connector protein; Region: Phage_connect_1; pfam05135 272622003329 phage protein, HK97 gp10 family; Region: phge_HK97_gp10; TIGR01725 272622003330 phage major tail protein, TP901-1 family; Region: phgtail_TP901_1; TIGR02126 272622003331 Phage protein; Region: DUF3647; pfam12363 272622003332 Phage-related minor tail protein [Function unknown]; Region: COG5280 272622003333 tape measure domain; Region: tape_meas_nterm; TIGR02675 272622003334 Phage-related protein [Function unknown]; Region: COG5412 272622003335 putative phage tail component, N-terminal domain; Region: phi3626_gp14_N; TIGR01633 272622003336 phage minor structural protein, N-terminal region; Region: put_anti_recept; TIGR01665 272622003337 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 272622003338 Peptidase family M23; Region: Peptidase_M23; pfam01551 272622003339 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 272622003340 Cpl-1 lysin (also known as Cpl-9 lysozyme / muramidase) is a bacterial cell wall endolysin encoded by the pneumococcal bacteriophage Cp-1, which cleaves the glycosidic N-acetylmuramoyl-(beta1,4)-N-acetylglucosamine bonds of the pneumococcal glycan chain; Region: GH25_Cpl1-like; cd06415 272622003341 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 272622003342 active site 272622003343 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 272622003344 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 272622003345 putative zinc finger/helix-turn-helix protein, YgiT family; Region: CxxCG_CxxCG_HTH; TIGR03830 272622003346 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272622003347 non-specific DNA binding site [nucleotide binding]; other site 272622003348 salt bridge; other site 272622003349 sequence-specific DNA binding site [nucleotide binding]; other site 272622003350 Uncharacterized phage-associated protein [Function unknown]; Region: GepA; COG3600 272622003351 AT-rich DNA-binding protein [General function prediction only]; Region: COG2344 272622003352 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 272622003353 CoA binding domain; Region: CoA_binding; pfam02629 272622003354 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 272622003355 ArsC family; Region: ArsC; pfam03960 272622003356 putative catalytic residues [active] 272622003357 thiol/disulfide switch; other site 272622003358 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 272622003359 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 272622003360 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272622003361 Walker A/P-loop; other site 272622003362 ATP binding site [chemical binding]; other site 272622003363 Q-loop/lid; other site 272622003364 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 272622003365 ABC transporter signature motif; other site 272622003366 Walker B; other site 272622003367 D-loop; other site 272622003368 ABC transporter; Region: ABC_tran_2; pfam12848 272622003369 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 272622003370 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 272622003371 active site 272622003372 dihydroorotase; Validated; Region: pyrC; PRK09357 272622003373 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 272622003374 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 272622003375 active site 272622003376 Transposase; Region: HTH_Tnp_1; cl17663 272622003377 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 272622003378 Sel1-like repeats; Region: SEL1; smart00671 272622003379 Sel1 repeat; Region: Sel1; cl02723 272622003380 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 272622003381 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 272622003382 Transposase, Mutator family; Region: Transposase_mut; pfam00872 272622003383 MULE transposase domain; Region: MULE; pfam10551 272622003384 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 272622003385 Transposase; Region: HTH_Tnp_1; pfam01527 272622003386 putative transposase OrfB; Reviewed; Region: PHA02517 272622003387 HTH-like domain; Region: HTH_21; pfam13276 272622003388 Integrase core domain; Region: rve; pfam00665 272622003389 Integrase core domain; Region: rve_3; pfam13683 272622003390 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 272622003391 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 272622003392 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 272622003393 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 272622003394 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 272622003395 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 272622003396 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 272622003397 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 272622003398 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 272622003399 active site 272622003400 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 272622003401 DnaD and phage-associated domain; Region: DnaD_dom; TIGR01446 272622003402 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 272622003403 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 272622003404 minor groove reading motif; other site 272622003405 helix-hairpin-helix signature motif; other site 272622003406 substrate binding pocket [chemical binding]; other site 272622003407 active site 272622003408 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 272622003409 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 272622003410 Family of unknown function (DUF633); Region: DUF633; pfam04816 272622003411 Uncharacterized conserved protein [Function unknown]; Region: COG0327 272622003412 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 272622003413 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4918 272622003414 sugar phosphate phosphatase; Provisional; Region: PRK10513 272622003415 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272622003416 active site 272622003417 motif I; other site 272622003418 motif II; other site 272622003419 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272622003420 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 272622003421 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 272622003422 Zn2+ binding site [ion binding]; other site 272622003423 Mg2+ binding site [ion binding]; other site 272622003424 Domain of unknown function (DUF1934); Region: DUF1934; pfam09148 272622003425 Predicted membrane protein [Function unknown]; Region: COG3371 272622003426 Protein of unknown function (DUF998); Region: DUF998; pfam06197 272622003427 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 272622003428 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 272622003429 Predicted ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG2868 272622003430 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 272622003431 manganese transport protein MntH; Reviewed; Region: PRK00701 272622003432 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 272622003433 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 272622003434 PhoH-like protein; Region: PhoH; pfam02562 272622003435 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 272622003436 nudix motif; other site 272622003437 metal-binding heat shock protein; Provisional; Region: PRK00016 272622003438 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 272622003439 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3575 272622003440 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 272622003441 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 272622003442 active site 272622003443 Uncharacterized conserved protein [Function unknown]; Region: COG1739 272622003444 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 272622003445 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 272622003446 hypothetical protein; Provisional; Region: PRK14013 272622003447 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 272622003448 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 272622003449 active site 272622003450 metal binding site [ion binding]; metal-binding site 272622003451 T5orf172 domain; Region: T5orf172; pfam10544 272622003452 glycyl-tRNA synthetase subunit alpha; Validated; Region: glyQ; PRK09348 272622003453 motif 1; other site 272622003454 dimer interface [polypeptide binding]; other site 272622003455 active site 272622003456 motif 2; other site 272622003457 motif 3; other site 272622003458 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 272622003459 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 272622003460 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 272622003461 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4224 272622003462 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 272622003463 ClC sycA-like chloride channel proteins. This ClC family presents in bacteria, where it facilitates acid resistance in acidic soil. Mutation of this gene (sycA) in Rhizobium tropici CIAT899 causes serious deficiencies in nodule development, nodulation...; Region: ClC_sycA_like; cd03682 272622003464 putative Cl- selectivity filter; other site 272622003465 putative pore gating glutamate residue; other site 272622003466 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 272622003467 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 272622003468 active site 272622003469 (T/H)XGH motif; other site 272622003470 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 272622003471 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 272622003472 active site 272622003473 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 272622003474 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272622003475 Coenzyme A binding pocket [chemical binding]; other site 272622003476 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 272622003477 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 272622003478 homodimer interface [polypeptide binding]; other site 272622003479 NAD binding pocket [chemical binding]; other site 272622003480 ATP binding pocket [chemical binding]; other site 272622003481 Mg binding site [ion binding]; other site 272622003482 active-site loop [active] 272622003483 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 272622003484 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 272622003485 Walker A/P-loop; other site 272622003486 ATP binding site [chemical binding]; other site 272622003487 Q-loop/lid; other site 272622003488 ABC transporter signature motif; other site 272622003489 Walker B; other site 272622003490 D-loop; other site 272622003491 H-loop/switch region; other site 272622003492 FtsX-like permease family; Region: FtsX; pfam02687 272622003493 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 272622003494 FtsX-like permease family; Region: FtsX; pfam02687 272622003495 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 272622003496 catalytic triad [active] 272622003497 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 272622003498 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 272622003499 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 272622003500 Alpha-acetolactate decarboxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AlsD; COG3527 272622003501 GTP-binding protein LepA; Provisional; Region: PRK05433 272622003502 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 272622003503 G1 box; other site 272622003504 putative GEF interaction site [polypeptide binding]; other site 272622003505 GTP/Mg2+ binding site [chemical binding]; other site 272622003506 Switch I region; other site 272622003507 G2 box; other site 272622003508 G3 box; other site 272622003509 Switch II region; other site 272622003510 G4 box; other site 272622003511 G5 box; other site 272622003512 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 272622003513 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 272622003514 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 272622003515 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 272622003516 NADH(P)-binding; Region: NAD_binding_10; pfam13460 272622003517 NAD(P) binding site [chemical binding]; other site 272622003518 putative active site [active] 272622003519 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 272622003520 Transposase; Region: HTH_Tnp_1; pfam01527 272622003521 putative transposase OrfB; Reviewed; Region: PHA02517 272622003522 HTH-like domain; Region: HTH_21; pfam13276 272622003523 Integrase core domain; Region: rve; pfam00665 272622003524 Integrase core domain; Region: rve_3; pfam13683 272622003525 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 272622003526 Methyltransferase domain; Region: Methyltransf_26; pfam13659 272622003527 DNA gyrase subunit A; Validated; Region: PRK05560 272622003528 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 272622003529 CAP-like domain; other site 272622003530 active site 272622003531 primary dimer interface [polypeptide binding]; other site 272622003532 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 272622003533 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 272622003534 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 272622003535 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 272622003536 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 272622003537 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 272622003538 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 272622003539 ApbE family; Region: ApbE; pfam02424 272622003540 Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165 272622003541 active site 272622003542 catalytic site [active] 272622003543 Domain of unknown function (DUF373); Region: DUF373; cl12079 272622003544 Uncharacterized conserved protein [Function unknown]; Region: COG2898 272622003545 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 272622003546 Lysyl-tRNA synthetase (class II) [Translation, ribosomal structure and biogenesis]; Region: LysU; COG1190 272622003547 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 272622003548 dimer interface [polypeptide binding]; other site 272622003549 putative anticodon binding site; other site 272622003550 Protein of unknown function (DUF998); Region: DUF998; pfam06197 272622003551 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 272622003552 Part of AAA domain; Region: AAA_19; pfam13245 272622003553 Family description; Region: UvrD_C_2; pfam13538 272622003554 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 272622003555 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 272622003556 dimer interface [polypeptide binding]; other site 272622003557 fumarate reductase flavoprotein subunit; Validated; Region: PRK06481 272622003558 L-aspartate oxidase; Provisional; Region: PRK06175 272622003559 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 272622003560 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 272622003561 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 272622003562 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 272622003563 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 272622003564 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK02484 272622003565 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 272622003566 RNA binding site [nucleotide binding]; other site 272622003567 active site 272622003568 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 272622003569 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 272622003570 active site 272622003571 Riboflavin kinase; Region: Flavokinase; smart00904 272622003572 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 272622003573 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 272622003574 dimer interface [polypeptide binding]; other site 272622003575 tetramer (dimer of dimers) interface [polypeptide binding]; other site 272622003576 NAD binding site [chemical binding]; other site 272622003577 substrate binding site [chemical binding]; other site 272622003578 Uncharacterized conserved protein [Function unknown]; Region: COG3589 272622003579 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 272622003580 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 272622003581 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 272622003582 putative active site [active] 272622003583 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 272622003584 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 272622003585 active site turn [active] 272622003586 phosphorylation site [posttranslational modification] 272622003587 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 272622003588 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 272622003589 HPr interaction site; other site 272622003590 glycerol kinase (GK) interaction site [polypeptide binding]; other site 272622003591 active site 272622003592 phosphorylation site [posttranslational modification] 272622003593 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 272622003594 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 272622003595 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 272622003596 putative active site [active] 272622003597 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 272622003598 triosephosphate isomerase; Provisional; Region: PRK14565 272622003599 substrate binding site [chemical binding]; other site 272622003600 dimer interface [polypeptide binding]; other site 272622003601 catalytic triad [active] 272622003602 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 272622003603 ParB-like nuclease domain; Region: ParB; smart00470 272622003604 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 272622003605 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272622003606 FeS/SAM binding site; other site 272622003607 HemN C-terminal domain; Region: HemN_C; pfam06969 272622003608 Lyzozyme M1 (1,4-beta-N-acetylmuramidase) [Cell envelope biogenesis, outer membrane]; Region: Acm; COG3757 272622003609 PlyB is a bacteriophage endolysin that displays potent lytic activity toward Bacillus anthracis. PlyB has an N-terminal glycosyl hydrolase family 25 (GH25) catalytic domain and a C-terminal bacterial SH3-like domain, SH3b. Both domains are required for...; Region: GH25_PlyB-like; cd06523 272622003610 active site 272622003611 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 272622003612 catalytic motif [active] 272622003613 Zn binding site [ion binding]; other site 272622003614 Acyl-ACP thioesterase [Lipid metabolism]; Region: FatA; COG3884 272622003615 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 272622003616 active site 272622003617 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 272622003618 active site 2 [active] 272622003619 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 272622003620 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272622003621 active site 272622003622 motif I; other site 272622003623 motif II; other site 272622003624 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272622003625 Predicted membrane protein [Function unknown]; Region: COG4478 272622003626 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 272622003627 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 272622003628 active site 272622003629 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 272622003630 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 272622003631 active site 272622003632 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 272622003633 active site 272622003634 xanthine permease; Region: pbuX; TIGR03173 272622003635 Sulfate transporter family; Region: Sulfate_transp; pfam00916 272622003636 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 272622003637 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 272622003638 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 272622003639 folate binding site [chemical binding]; other site 272622003640 NADP+ binding site [chemical binding]; other site 272622003641 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 272622003642 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 272622003643 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272622003644 Walker A motif; other site 272622003645 ATP binding site [chemical binding]; other site 272622003646 Walker B motif; other site 272622003647 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 272622003648 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 272622003649 G1 box; other site 272622003650 GTP/Mg2+ binding site [chemical binding]; other site 272622003651 Switch I region; other site 272622003652 G2 box; other site 272622003653 G3 box; other site 272622003654 Switch II region; other site 272622003655 G4 box; other site 272622003656 G5 box; other site 272622003657 Dihydroneopterin aldolase [Coenzyme metabolism]; Region: FolB; COG1539 272622003658 active site 272622003659 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 272622003660 catalytic center binding site [active] 272622003661 ATP binding site [chemical binding]; other site 272622003662 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 272622003663 GTP cyclohydrolase I; Provisional; Region: PLN03044 272622003664 active site 272622003665 dihydropteroate synthase; Region: DHPS; TIGR01496 272622003666 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 272622003667 substrate binding pocket [chemical binding]; other site 272622003668 dimer interface [polypeptide binding]; other site 272622003669 inhibitor binding site; inhibition site 272622003670 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 272622003671 nudix motif; other site 272622003672 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 272622003673 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 272622003674 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 272622003675 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 272622003676 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 272622003677 Substrate-binding site [chemical binding]; other site 272622003678 Substrate specificity [chemical binding]; other site 272622003679 homoserine dehydrogenase; Provisional; Region: PRK06349 272622003680 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 272622003681 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 272622003682 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 272622003683 homoserine kinase; Provisional; Region: PRK01212 272622003684 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 272622003685 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 272622003686 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 272622003687 FAD binding domain; Region: FAD_binding_4; pfam01565 272622003688 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 272622003689 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 272622003690 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272622003691 Walker A/P-loop; other site 272622003692 ATP binding site [chemical binding]; other site 272622003693 Q-loop/lid; other site 272622003694 ABC transporter signature motif; other site 272622003695 Walker B; other site 272622003696 D-loop; other site 272622003697 H-loop/switch region; other site 272622003698 TOBE domain; Region: TOBE_2; pfam08402 272622003699 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272622003700 dimer interface [polypeptide binding]; other site 272622003701 conserved gate region; other site 272622003702 putative PBP binding loops; other site 272622003703 ABC-ATPase subunit interface; other site 272622003704 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 272622003705 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272622003706 dimer interface [polypeptide binding]; other site 272622003707 conserved gate region; other site 272622003708 putative PBP binding loops; other site 272622003709 ABC-ATPase subunit interface; other site 272622003710 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 272622003711 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 272622003712 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 272622003713 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 272622003714 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272622003715 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272622003716 Major Facilitator Superfamily; Region: MFS_1; pfam07690 272622003717 putative substrate translocation pore; other site 272622003718 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 272622003719 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 272622003720 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 272622003721 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 272622003722 inhibitor binding site; inhibition site 272622003723 active site 272622003724 putative transposase OrfB; Reviewed; Region: PHA02517 272622003725 HTH-like domain; Region: HTH_21; pfam13276 272622003726 Integrase core domain; Region: rve; pfam00665 272622003727 Integrase core domain; Region: rve_3; pfam13683 272622003728 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 272622003729 Transposase; Region: HTH_Tnp_1; pfam01527 272622003730 hypothetical protein; Provisional; Region: PRK14013 272622003731 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 272622003732 dimerization interface [polypeptide binding]; other site 272622003733 putative DNA binding site [nucleotide binding]; other site 272622003734 putative Zn2+ binding site [ion binding]; other site 272622003735 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 272622003736 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 272622003737 potential catalytic triad [active] 272622003738 conserved cys residue [active] 272622003739 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272622003740 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 272622003741 NAD(P) binding site [chemical binding]; other site 272622003742 active site 272622003743 site-specific tyrosine recombinase XerS; Reviewed; Region: xerS; PRK05084 272622003744 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 272622003745 active site 272622003746 DNA binding site [nucleotide binding] 272622003747 Int/Topo IB signature motif; other site 272622003748 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 272622003749 Glucose inhibited division protein A; Region: GIDA; pfam01134 272622003750 DNA topoisomerase I; Validated; Region: PRK05582 272622003751 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 272622003752 active site 272622003753 interdomain interaction site; other site 272622003754 putative metal-binding site [ion binding]; other site 272622003755 nucleotide binding site [chemical binding]; other site 272622003756 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 272622003757 domain I; other site 272622003758 DNA binding groove [nucleotide binding] 272622003759 phosphate binding site [ion binding]; other site 272622003760 domain II; other site 272622003761 domain III; other site 272622003762 nucleotide binding site [chemical binding]; other site 272622003763 catalytic site [active] 272622003764 domain IV; other site 272622003765 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 272622003766 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 272622003767 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 272622003768 DNA protecting protein DprA; Region: dprA; TIGR00732 272622003769 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 272622003770 homotrimer interaction site [polypeptide binding]; other site 272622003771 putative active site [active] 272622003772 alpha-acetolactate decarboxylase; Region: acetolac_decarb; TIGR01252 272622003773 ketol-acid reductoisomerase; Provisional; Region: PRK05479 272622003774 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 272622003775 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 272622003776 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 272622003777 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 272622003778 putative valine binding site [chemical binding]; other site 272622003779 dimer interface [polypeptide binding]; other site 272622003780 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 272622003781 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07282 272622003782 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 272622003783 PYR/PP interface [polypeptide binding]; other site 272622003784 dimer interface [polypeptide binding]; other site 272622003785 TPP binding site [chemical binding]; other site 272622003786 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 272622003787 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 272622003788 TPP-binding site [chemical binding]; other site 272622003789 dimer interface [polypeptide binding]; other site 272622003790 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 272622003791 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 272622003792 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272622003793 Walker A/P-loop; other site 272622003794 ATP binding site [chemical binding]; other site 272622003795 ABC transporter signature motif; other site 272622003796 Walker B; other site 272622003797 D-loop; other site 272622003798 H-loop/switch region; other site 272622003799 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 272622003800 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 272622003801 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 272622003802 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 272622003803 substrate binding site [chemical binding]; other site 272622003804 ligand binding site [chemical binding]; other site 272622003805 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_30; cd04689 272622003806 nudix motif; other site 272622003807 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 272622003808 tartrate dehydrogenase; Region: TTC; TIGR02089 272622003809 Protein of unknown function (DUF805); Region: DUF805; pfam05656 272622003810 2-isopropylmalate synthase; Validated; Region: PRK00915 272622003811 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 272622003812 active site 272622003813 catalytic residues [active] 272622003814 metal binding site [ion binding]; metal-binding site 272622003815 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 272622003816 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 272622003817 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 272622003818 active site residue [active] 272622003819 Protein of unknown function (DUF3650); Region: DUF3650; pfam12368 272622003820 histidinol phosphate phosphatase, HisJ family; Region: hisJ_fam; TIGR01856 272622003821 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 272622003822 active site 272622003823 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 272622003824 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 272622003825 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 272622003826 metal binding site [ion binding]; metal-binding site 272622003827 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 272622003828 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 272622003829 substrate binding site [chemical binding]; other site 272622003830 glutamase interaction surface [polypeptide binding]; other site 272622003831 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 272622003832 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 272622003833 catalytic residues [active] 272622003834 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 272622003835 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 272622003836 putative active site [active] 272622003837 oxyanion strand; other site 272622003838 catalytic triad [active] 272622003839 Phosphotransferase enzyme family; Region: APH; pfam01636 272622003840 Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin...; Region: APH; cd05150 272622003841 active site 272622003842 ATP binding site [chemical binding]; other site 272622003843 antibiotic binding site [chemical binding]; other site 272622003844 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 272622003845 putative active site pocket [active] 272622003846 4-fold oligomerization interface [polypeptide binding]; other site 272622003847 metal binding residues [ion binding]; metal-binding site 272622003848 3-fold/trimer interface [polypeptide binding]; other site 272622003849 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 272622003850 histidinol dehydrogenase; Region: hisD; TIGR00069 272622003851 NAD binding site [chemical binding]; other site 272622003852 dimerization interface [polypeptide binding]; other site 272622003853 product binding site; other site 272622003854 substrate binding site [chemical binding]; other site 272622003855 zinc binding site [ion binding]; other site 272622003856 catalytic residues [active] 272622003857 ATP phosphoribosyltransferase, regulatory subunit; Region: hisZ_biosyn_reg; TIGR00443 272622003858 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 272622003859 dimer interface [polypeptide binding]; other site 272622003860 motif 1; other site 272622003861 active site 272622003862 motif 2; other site 272622003863 motif 3; other site 272622003864 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 272622003865 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 272622003866 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272622003867 homodimer interface [polypeptide binding]; other site 272622003868 catalytic residue [active] 272622003869 Protein of unknown function (DUF1295); Region: DUF1295; cl17837 272622003870 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 272622003871 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 272622003872 Predicted membrane protein [Function unknown]; Region: COG4852 272622003873 TspO/MBR family; Region: TspO_MBR; pfam03073 272622003874 ribonuclease R; Region: RNase_R; TIGR02063 272622003875 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 272622003876 RNB domain; Region: RNB; pfam00773 272622003877 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 272622003878 RNA binding site [nucleotide binding]; other site 272622003879 Transposase, Mutator family; Region: Transposase_mut; pfam00872 272622003880 MULE transposase domain; Region: MULE; pfam10551 272622003881 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272622003882 non-specific DNA binding site [nucleotide binding]; other site 272622003883 salt bridge; other site 272622003884 sequence-specific DNA binding site [nucleotide binding]; other site 272622003885 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 272622003886 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 272622003887 Predicted transcriptional regulators [Transcription]; Region: COG1733 272622003888 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 272622003889 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272622003890 Major Facilitator Superfamily; Region: MFS_1; pfam07690 272622003891 putative substrate translocation pore; other site 272622003892 acetolactate synthase; Reviewed; Region: PRK08617 272622003893 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 272622003894 PYR/PP interface [polypeptide binding]; other site 272622003895 dimer interface [polypeptide binding]; other site 272622003896 TPP binding site [chemical binding]; other site 272622003897 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 272622003898 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 272622003899 TPP-binding site [chemical binding]; other site 272622003900 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272622003901 binding surface 272622003902 TPR motif; other site 272622003903 Tetratricopeptide repeat; Region: TPR_12; pfam13424 272622003904 Tetratricopeptide repeat; Region: TPR_12; pfam13424 272622003905 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272622003906 binding surface 272622003907 TPR motif; other site 272622003908 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 272622003909 Domain of unknown function DUF20; Region: UPF0118; pfam01594 272622003910 Methyltransferase domain; Region: Methyltransf_23; pfam13489 272622003911 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272622003912 S-adenosylmethionine binding site [chemical binding]; other site 272622003913 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 272622003914 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 272622003915 TRAM domain; Region: TRAM; cl01282 272622003916 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272622003917 S-adenosylmethionine binding site [chemical binding]; other site 272622003918 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 272622003919 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 272622003920 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 272622003921 putative active site [active] 272622003922 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 272622003923 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 272622003924 putative active site cavity [active] 272622003925 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 272622003926 HTH-like domain; Region: HTH_21; pfam13276 272622003927 Integrase core domain; Region: rve; pfam00665 272622003928 Integrase core domain; Region: rve_3; pfam13683 272622003929 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 272622003930 Transposase; Region: HTH_Tnp_1; pfam01527 272622003931 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 272622003932 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 272622003933 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 272622003934 Transposase, Mutator family; Region: Transposase_mut; pfam00872 272622003935 MULE transposase domain; Region: MULE; pfam10551 272622003936 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 272622003937 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 272622003938 active site 272622003939 catalytic tetrad [active] 272622003940 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 272622003941 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 272622003942 DNA binding residues [nucleotide binding] 272622003943 putative dimer interface [polypeptide binding]; other site 272622003944 ArsC family; Region: ArsC; pfam03960 272622003945 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 272622003946 putative catalytic residues [active] 272622003947 thiol/disulfide switch; other site 272622003948 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 272622003949 Transposase; Region: HTH_Tnp_1; pfam01527 272622003950 putative transposase OrfB; Reviewed; Region: PHA02517 272622003951 HTH-like domain; Region: HTH_21; pfam13276 272622003952 Integrase core domain; Region: rve; pfam00665 272622003953 Integrase core domain; Region: rve_3; pfam13683 272622003954 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 272622003955 FAD binding site [chemical binding]; other site 272622003956 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 272622003957 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 272622003958 THF binding site; other site 272622003959 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 272622003960 substrate binding site [chemical binding]; other site 272622003961 THF binding site; other site 272622003962 zinc-binding site [ion binding]; other site 272622003963 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 272622003964 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 272622003965 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 272622003966 magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517 272622003967 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 272622003968 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 272622003969 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 272622003970 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 272622003971 Soluble P-type ATPase [General function prediction only]; Region: COG4087 272622003972 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 272622003973 Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltD; COG3966 272622003974 DltD N-terminal region; Region: DltD_N; pfam04915 272622003975 DltD central region; Region: DltD_M; pfam04918 272622003976 DltD C-terminal region; Region: DltD_C; pfam04914 272622003977 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 272622003978 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 272622003979 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 272622003980 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 272622003981 acyl-activating enzyme (AAE) consensus motif; other site 272622003982 AMP binding site [chemical binding]; other site 272622003983 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 272622003984 thiamine phosphate binding site [chemical binding]; other site 272622003985 active site 272622003986 pyrophosphate binding site [ion binding]; other site 272622003987 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 272622003988 substrate binding site [chemical binding]; other site 272622003989 dimer interface [polypeptide binding]; other site 272622003990 ATP binding site [chemical binding]; other site 272622003991 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 272622003992 substrate binding site [chemical binding]; other site 272622003993 multimerization interface [polypeptide binding]; other site 272622003994 ATP binding site [chemical binding]; other site 272622003995 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 272622003996 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 272622003997 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 272622003998 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272622003999 putative substrate translocation pore; other site 272622004000 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 272622004001 core dimer interface [polypeptide binding]; other site 272622004002 peripheral dimer interface [polypeptide binding]; other site 272622004003 L10 interface [polypeptide binding]; other site 272622004004 L11 interface [polypeptide binding]; other site 272622004005 putative EF-Tu interaction site [polypeptide binding]; other site 272622004006 putative EF-G interaction site [polypeptide binding]; other site 272622004007 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 272622004008 23S rRNA interface [nucleotide binding]; other site 272622004009 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 272622004010 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 272622004011 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272622004012 non-specific DNA binding site [nucleotide binding]; other site 272622004013 salt bridge; other site 272622004014 sequence-specific DNA binding site [nucleotide binding]; other site 272622004015 Predicted transcriptional regulator [Transcription]; Region: COG2932 272622004016 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 272622004017 Catalytic site [active] 272622004018 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 272622004019 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 272622004020 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 272622004021 Walker A/P-loop; other site 272622004022 ATP binding site [chemical binding]; other site 272622004023 Q-loop/lid; other site 272622004024 ABC transporter signature motif; other site 272622004025 Walker B; other site 272622004026 D-loop; other site 272622004027 H-loop/switch region; other site 272622004028 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 272622004029 Predicted membrane protein [Function unknown]; Region: COG3601 272622004030 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 272622004031 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 272622004032 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 272622004033 RNA binding surface [nucleotide binding]; other site 272622004034 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 272622004035 active site 272622004036 segregation and condensation protein B; Reviewed; Region: scpB; PRK00135 272622004037 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 272622004038 site-specific tyrosine recombinase XerD-like protein; Reviewed; Region: xerD; PRK02436 272622004039 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495 272622004040 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 272622004041 active site 272622004042 catalytic residues [active] 272622004043 DNA binding site [nucleotide binding] 272622004044 Int/Topo IB signature motif; other site 272622004045 FOG: CBS domain [General function prediction only]; Region: COG0517 272622004046 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 272622004047 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 272622004048 active site 272622004049 metal binding site [ion binding]; metal-binding site 272622004050 homotetramer interface [polypeptide binding]; other site 272622004051 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 272622004052 active site 272622004053 dimerization interface [polypeptide binding]; other site 272622004054 glutamate racemase; Provisional; Region: PRK00865 272622004055 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3763 272622004056 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 272622004057 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 272622004058 active site 272622004059 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 272622004060 substrate binding site [chemical binding]; other site 272622004061 catalytic residues [active] 272622004062 dimer interface [polypeptide binding]; other site 272622004063 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 272622004064 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 272622004065 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 272622004066 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 272622004067 active site 272622004068 dimer interface [polypeptide binding]; other site 272622004069 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 272622004070 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 272622004071 active site 272622004072 FMN binding site [chemical binding]; other site 272622004073 substrate binding site [chemical binding]; other site 272622004074 3Fe-4S cluster binding site [ion binding]; other site 272622004075 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 272622004076 domain interface; other site 272622004077 maltose O-acetyltransferase; Provisional; Region: PRK10092 272622004078 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 272622004079 active site 272622004080 substrate binding site [chemical binding]; other site 272622004081 trimer interface [polypeptide binding]; other site 272622004082 CoA binding site [chemical binding]; other site 272622004083 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 272622004084 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 272622004085 homodimer interface [polypeptide binding]; other site 272622004086 substrate-cofactor binding pocket; other site 272622004087 catalytic residue [active] 272622004088 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 272622004089 Mechanosensitive ion channel; Region: MS_channel; pfam00924 272622004090 glutamate:gamma-aminobutyrate antiporter; Region: 2A0307_GadC; TIGR00910 272622004091 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272622004092 non-specific DNA binding site [nucleotide binding]; other site 272622004093 salt bridge; other site 272622004094 sequence-specific DNA binding site [nucleotide binding]; other site 272622004095 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 272622004096 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 272622004097 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 272622004098 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 272622004099 RNA/DNA hybrid binding site [nucleotide binding]; other site 272622004100 active site 272622004101 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 272622004102 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 272622004103 GTP/Mg2+ binding site [chemical binding]; other site 272622004104 G4 box; other site 272622004105 G5 box; other site 272622004106 G1 box; other site 272622004107 Switch I region; other site 272622004108 G2 box; other site 272622004109 G3 box; other site 272622004110 Switch II region; other site 272622004111 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 272622004112 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 272622004113 active site 272622004114 DNA binding site [nucleotide binding] 272622004115 Int/Topo IB signature motif; other site 272622004116 putative replication initiation protein; Region: PHA00330 272622004117 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 272622004118 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 272622004119 TaqI-like C-terminal specificity domain; Region: TaqI_C; pfam12950 272622004120 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 272622004121 Coenzyme A binding pocket [chemical binding]; other site 272622004122 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 272622004123 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 272622004124 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 272622004125 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 272622004126 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 272622004127 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 272622004128 active site 272622004129 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 272622004130 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 272622004131 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272622004132 dimer interface [polypeptide binding]; other site 272622004133 conserved gate region; other site 272622004134 putative PBP binding loops; other site 272622004135 ABC-ATPase subunit interface; other site 272622004136 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 272622004137 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 272622004138 Domain of unknown function (DUF303); Region: DUF303; pfam03629 272622004139 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 272622004140 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 272622004141 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 272622004142 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 272622004143 ABC-ATPase subunit interface; other site 272622004144 dimer interface [polypeptide binding]; other site 272622004145 putative PBP binding regions; other site 272622004146 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 272622004147 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 272622004148 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 272622004149 Domain of unknown function (DUF4176); Region: DUF4176; cl01867 272622004150 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 272622004151 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 272622004152 Walker A/P-loop; other site 272622004153 ATP binding site [chemical binding]; other site 272622004154 Q-loop/lid; other site 272622004155 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272622004156 ABC transporter signature motif; other site 272622004157 Walker B; other site 272622004158 D-loop; other site 272622004159 H-loop/switch region; other site 272622004160 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 272622004161 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 272622004162 active site 272622004163 metal binding site [ion binding]; metal-binding site 272622004164 DNA binding site [nucleotide binding] 272622004165 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 272622004166 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 272622004167 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 272622004168 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 272622004169 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 272622004170 ArsC family; Region: ArsC; pfam03960 272622004171 putative catalytic residues [active] 272622004172 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 272622004173 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 272622004174 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 272622004175 Domain of unknown function (DUF814); Region: DUF814; pfam05670 272622004176 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 272622004177 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272622004178 S-adenosylmethionine binding site [chemical binding]; other site 272622004179 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 272622004180 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 272622004181 Walker A/P-loop; other site 272622004182 ATP binding site [chemical binding]; other site 272622004183 Q-loop/lid; other site 272622004184 ABC transporter signature motif; other site 272622004185 Walker B; other site 272622004186 D-loop; other site 272622004187 H-loop/switch region; other site 272622004188 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 272622004189 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 272622004190 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 272622004191 TM-ABC transporter signature motif; other site 272622004192 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 272622004193 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 272622004194 TM-ABC transporter signature motif; other site 272622004195 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 272622004196 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 272622004197 tetramer (dimer of dimers) interface [polypeptide binding]; other site 272622004198 NAD binding site [chemical binding]; other site 272622004199 dimer interface [polypeptide binding]; other site 272622004200 substrate binding site [chemical binding]; other site 272622004201 pyruvate kinase; Provisional; Region: PRK05826 272622004202 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 272622004203 domain interfaces; other site 272622004204 active site 272622004205 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 272622004206 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 272622004207 active site 272622004208 ADP/pyrophosphate binding site [chemical binding]; other site 272622004209 dimerization interface [polypeptide binding]; other site 272622004210 allosteric effector site; other site 272622004211 fructose-1,6-bisphosphate binding site; other site 272622004212 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 272622004213 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 272622004214 active site 272622004215 dimer interface [polypeptide binding]; other site 272622004216 Uncharacterized protein involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TelA; COG3853 272622004217 5-bromo-4-chloroindolyl phosphate hydrolysis protein [General function prediction only]; Region: XpaC; COG4915 272622004218 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 272622004219 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 272622004220 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 272622004221 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 272622004222 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 272622004223 active site 272622004224 tetramer interface; other site 272622004225 Listerrria innocua Lin0431 is similar to the N-Utilization Substance G (NusG) N terminal (NGN) insert (DII); Region: Lin0431_like; cd09911 272622004226 trimer interface [polypeptide binding]; other site 272622004227 Predicted membrane protein [Function unknown]; Region: COG4769 272622004228 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 272622004229 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 272622004230 substrate binding pocket [chemical binding]; other site 272622004231 chain length determination region; other site 272622004232 substrate-Mg2+ binding site; other site 272622004233 catalytic residues [active] 272622004234 aspartate-rich region 1; other site 272622004235 active site lid residues [active] 272622004236 aspartate-rich region 2; other site 272622004237 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 272622004238 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272622004239 S-adenosylmethionine binding site [chemical binding]; other site 272622004240 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 272622004241 active site 272622004242 dimer interface [polypeptide binding]; other site 272622004243 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 272622004244 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 272622004245 heterodimer interface [polypeptide binding]; other site 272622004246 active site 272622004247 FMN binding site [chemical binding]; other site 272622004248 homodimer interface [polypeptide binding]; other site 272622004249 substrate binding site [chemical binding]; other site 272622004250 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 272622004251 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 272622004252 FAD binding pocket [chemical binding]; other site 272622004253 FAD binding motif [chemical binding]; other site 272622004254 phosphate binding motif [ion binding]; other site 272622004255 beta-alpha-beta structure motif; other site 272622004256 NAD binding pocket [chemical binding]; other site 272622004257 Iron coordination center [ion binding]; other site 272622004258 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272622004259 Major Facilitator Superfamily; Region: MFS_1; pfam07690 272622004260 putative substrate translocation pore; other site 272622004261 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 272622004262 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 272622004263 DNA-binding site [nucleotide binding]; DNA binding site 272622004264 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 272622004265 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 272622004266 beta-galactosidase; Region: BGL; TIGR03356 272622004267 short chain dehydrogenase; Provisional; Region: PRK12937 272622004268 classical (c) SDRs; Region: SDR_c; cd05233 272622004269 NAD(P) binding site [chemical binding]; other site 272622004270 active site 272622004271 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 272622004272 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272622004273 dimer interface [polypeptide binding]; other site 272622004274 conserved gate region; other site 272622004275 ABC-ATPase subunit interface; other site 272622004276 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272622004277 dimer interface [polypeptide binding]; other site 272622004278 conserved gate region; other site 272622004279 putative PBP binding loops; other site 272622004280 ABC-ATPase subunit interface; other site 272622004281 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 272622004282 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 272622004283 Membrane protease subunit, stomatin/prohibitin family [Amino acid transport and metabolism]; Region: COG4260 272622004284 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_5; cd03408 272622004285 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 272622004286 hypothetical protein; Provisional; Region: PRK12495 272622004287 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 272622004288 Repair protein; Region: Repair_PSII; pfam04536 272622004289 Pseudouridine synthase, Escherichia coli RluE; Region: PseudoU_synth_RluE; cd02566 272622004290 pseudouridine synthase; Region: TIGR00093 272622004291 probable active site [active] 272622004292 glycerol kinase; Provisional; Region: glpK; PRK00047 272622004293 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 272622004294 N- and C-terminal domain interface [polypeptide binding]; other site 272622004295 active site 272622004296 MgATP binding site [chemical binding]; other site 272622004297 catalytic site [active] 272622004298 metal binding site [ion binding]; metal-binding site 272622004299 glycerol binding site [chemical binding]; other site 272622004300 homotetramer interface [polypeptide binding]; other site 272622004301 homodimer interface [polypeptide binding]; other site 272622004302 FBP binding site [chemical binding]; other site 272622004303 protein IIAGlc interface [polypeptide binding]; other site 272622004304 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 272622004305 hydroxyglutarate oxidase; Provisional; Region: PRK11728 272622004306 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 272622004307 amphipathic channel; other site 272622004308 Asn-Pro-Ala signature motifs; other site 272622004309 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 272622004310 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 272622004311 WxL domain surface cell wall-binding; Region: WxL; pfam13731 272622004312 DDE domain; Region: DDE_Tnp_IS240; pfam13610 272622004313 Integrase core domain; Region: rve; pfam00665 272622004314 Integrase core domain; Region: rve_3; pfam13683 272622004315 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 272622004316 Transposase; Region: HTH_Tnp_1; pfam01527 272622004317 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 272622004318 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 272622004319 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 272622004320 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 272622004321 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 272622004322 ATP-grasp domain; Region: ATP-grasp_4; cl17255 272622004323 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 272622004324 IMP binding site; other site 272622004325 dimer interface [polypeptide binding]; other site 272622004326 interdomain contacts; other site 272622004327 partial ornithine binding site; other site 272622004328 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 272622004329 catalytic residues [active] 272622004330 dimer interface [polypeptide binding]; other site 272622004331 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 272622004332 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 272622004333 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 272622004334 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 272622004335 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272622004336 motif II; other site 272622004337 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 272622004338 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1636 272622004339 putative transposase OrfB; Reviewed; Region: PHA02517 272622004340 HTH-like domain; Region: HTH_21; pfam13276 272622004341 Integrase core domain; Region: rve; pfam00665 272622004342 Integrase core domain; Region: rve_3; pfam13683 272622004343 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 272622004344 Transposase; Region: HTH_Tnp_1; pfam01527 272622004345 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 272622004346 TraX protein; Region: TraX; cl05434 272622004347 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 272622004348 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 272622004349 Ligand Binding Site [chemical binding]; other site 272622004350 Protein of unknown function (DUF1093); Region: DUF1093; cl02185 272622004351 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 272622004352 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 272622004353 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 272622004354 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 272622004355 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 272622004356 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 272622004357 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 272622004358 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 272622004359 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 272622004360 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 272622004361 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 272622004362 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 272622004363 putative DNA-binding protein; Validated; Region: PRK00118 272622004364 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 272622004365 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 272622004366 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272622004367 active site 272622004368 phosphorylation site [posttranslational modification] 272622004369 intermolecular recognition site; other site 272622004370 dimerization interface [polypeptide binding]; other site 272622004371 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272622004372 DNA binding site [nucleotide binding] 272622004373 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272622004374 dimer interface [polypeptide binding]; other site 272622004375 phosphorylation site [posttranslational modification] 272622004376 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272622004377 ATP binding site [chemical binding]; other site 272622004378 Mg2+ binding site [ion binding]; other site 272622004379 G-X-G motif; other site 272622004380 Domain of unknown function (DUF4395); Region: DUF4395; pfam14340 272622004381 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 272622004382 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 272622004383 DNA-binding site [nucleotide binding]; DNA binding site 272622004384 UTRA domain; Region: UTRA; pfam07702 272622004385 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 272622004386 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 272622004387 ligand binding site [chemical binding]; other site 272622004388 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 272622004389 active site 272622004390 catalytic motif [active] 272622004391 Zn binding site [ion binding]; other site 272622004392 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 272622004393 intersubunit interface [polypeptide binding]; other site 272622004394 active site 272622004395 catalytic residue [active] 272622004396 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 272622004397 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 272622004398 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 272622004399 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 272622004400 Methyltransferase domain; Region: Methyltransf_31; pfam13847 272622004401 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272622004402 S-adenosylmethionine binding site [chemical binding]; other site 272622004403 pantothenate kinase; Provisional; Region: PRK05439 272622004404 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 272622004405 ATP-binding site [chemical binding]; other site 272622004406 CoA-binding site [chemical binding]; other site 272622004407 Mg2+-binding site [ion binding]; other site 272622004408 Phosphate-starvation-inducible E; Region: PsiE; cl01264 272622004409 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 272622004410 Cation efflux family; Region: Cation_efflux; pfam01545 272622004411 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272622004412 non-specific DNA binding site [nucleotide binding]; other site 272622004413 salt bridge; other site 272622004414 sequence-specific DNA binding site [nucleotide binding]; other site 272622004415 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 272622004416 ParB-like nuclease domain; Region: ParB; smart00470 272622004417 Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969 272622004418 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 272622004419 Active Sites [active] 272622004420 Domain of unknown function (DUF3440); Region: DUF3440; pfam11922 272622004421 Protein of unknown function (DUF3042); Region: DUF3042; pfam11240 272622004422 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272622004423 dimer interface [polypeptide binding]; other site 272622004424 conserved gate region; other site 272622004425 putative PBP binding loops; other site 272622004426 ABC-ATPase subunit interface; other site 272622004427 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 272622004428 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 272622004429 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 272622004430 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 272622004431 Walker A/P-loop; other site 272622004432 ATP binding site [chemical binding]; other site 272622004433 Q-loop/lid; other site 272622004434 ABC transporter signature motif; other site 272622004435 Walker B; other site 272622004436 D-loop; other site 272622004437 H-loop/switch region; other site 272622004438 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 272622004439 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 272622004440 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 272622004441 DNA-binding site [nucleotide binding]; DNA binding site 272622004442 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 272622004443 TrkA-C domain; Region: TrkA_C; pfam02080 272622004444 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 272622004445 beta-galactosidase; Region: BGL; TIGR03356 272622004446 CAT RNA binding domain; Region: CAT_RBD; pfam03123 272622004447 transcriptional antiterminator BglG; Provisional; Region: PRK09772 272622004448 PRD domain; Region: PRD; pfam00874 272622004449 PRD domain; Region: PRD; pfam00874 272622004450 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 272622004451 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 272622004452 substrate binding site [chemical binding]; other site 272622004453 active site 272622004454 catalytic residues [active] 272622004455 heterodimer interface [polypeptide binding]; other site 272622004456 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 272622004457 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 272622004458 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272622004459 catalytic residue [active] 272622004460 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 272622004461 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 272622004462 active site 272622004463 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 272622004464 active site 272622004465 ribulose/triose binding site [chemical binding]; other site 272622004466 phosphate binding site [ion binding]; other site 272622004467 substrate (anthranilate) binding pocket [chemical binding]; other site 272622004468 product (indole) binding pocket [chemical binding]; other site 272622004469 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 272622004470 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 272622004471 Protein of unknown function (DUF2806); Region: DUF2806; cl12560 272622004472 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 272622004473 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 272622004474 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 272622004475 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 272622004476 Glutamine amidotransferase class-I; Region: GATase; pfam00117 272622004477 glutamine binding [chemical binding]; other site 272622004478 catalytic triad [active] 272622004479 anthranilate synthase component I; Provisional; Region: PRK13570 272622004480 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 272622004481 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 272622004482 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 272622004483 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 272622004484 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 272622004485 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 272622004486 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 272622004487 metal binding site 2 [ion binding]; metal-binding site 272622004488 putative DNA binding helix; other site 272622004489 metal binding site 1 [ion binding]; metal-binding site 272622004490 dimer interface [polypeptide binding]; other site 272622004491 structural Zn2+ binding site [ion binding]; other site 272622004492 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 272622004493 EamA-like transporter family; Region: EamA; pfam00892 272622004494 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 272622004495 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 272622004496 DNA binding residues [nucleotide binding] 272622004497 putative dimer interface [polypeptide binding]; other site 272622004498 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 272622004499 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272622004500 NAD(P) binding site [chemical binding]; other site 272622004501 active site 272622004502 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK12315 272622004503 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 272622004504 TPP-binding site; other site 272622004505 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 272622004506 PYR/PP interface [polypeptide binding]; other site 272622004507 dimer interface [polypeptide binding]; other site 272622004508 TPP binding site [chemical binding]; other site 272622004509 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 272622004510 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 272622004511 MarR family; Region: MarR; pfam01047 272622004512 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 272622004513 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 272622004514 Cl binding site [ion binding]; other site 272622004515 oligomer interface [polypeptide binding]; other site 272622004516 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 272622004517 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 272622004518 Glycosyl hydrolase family 67 N-terminus; Region: Glyco_hydro_67N; pfam03648 272622004519 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 272622004520 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 272622004521 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 272622004522 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272622004523 dimer interface [polypeptide binding]; other site 272622004524 conserved gate region; other site 272622004525 ABC-ATPase subunit interface; other site 272622004526 GMP synthase; Reviewed; Region: guaA; PRK00074 272622004527 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 272622004528 AMP/PPi binding site [chemical binding]; other site 272622004529 candidate oxyanion hole; other site 272622004530 catalytic triad [active] 272622004531 potential glutamine specificity residues [chemical binding]; other site 272622004532 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 272622004533 ATP Binding subdomain [chemical binding]; other site 272622004534 Dimerization subdomain; other site 272622004535 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 272622004536 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 272622004537 nucleotide binding site [chemical binding]; other site 272622004538 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 272622004539 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 272622004540 nucleotide binding site [chemical binding]; other site 272622004541 butyrate kinase; Provisional; Region: PRK03011 272622004542 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 272622004543 beta-galactosidase; Region: BGL; TIGR03356 272622004544 Protein of unknown function, DUF624; Region: DUF624; cl02369 272622004545 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 272622004546 active site pocket [active] 272622004547 oxyanion hole [active] 272622004548 catalytic triad [active] 272622004549 active site nucleophile [active] 272622004550 putative transposase OrfB; Reviewed; Region: PHA02517 272622004551 HTH-like domain; Region: HTH_21; pfam13276 272622004552 Integrase core domain; Region: rve; pfam00665 272622004553 Integrase core domain; Region: rve_3; pfam13683 272622004554 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 272622004555 Transposase; Region: HTH_Tnp_1; pfam01527 272622004556 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 272622004557 active site 272622004558 catalytic residues [active] 272622004559 Glycosyl hydrolases family 11; Region: Glyco_hydro_11; pfam00457 272622004560 xylose isomerase; Provisional; Region: PRK05474 272622004561 Cupin domain; Region: Cupin_2; pfam07883 272622004562 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272622004563 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 272622004564 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 272622004565 ATP-grasp domain; Region: ATP-grasp; pfam02222 272622004566 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 272622004567 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 272622004568 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 272622004569 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 272622004570 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 272622004571 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 272622004572 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 272622004573 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 272622004574 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 272622004575 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272622004576 Major Facilitator Superfamily; Region: MFS_1; pfam07690 272622004577 putative substrate translocation pore; other site 272622004578 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272622004579 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 272622004580 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272622004581 motif II; other site 272622004582 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 272622004583 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 272622004584 purine monophosphate binding site [chemical binding]; other site 272622004585 dimer interface [polypeptide binding]; other site 272622004586 putative catalytic residues [active] 272622004587 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 272622004588 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 272622004589 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 272622004590 active site 272622004591 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 272622004592 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 272622004593 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 272622004594 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 272622004595 Walker A/P-loop; other site 272622004596 ATP binding site [chemical binding]; other site 272622004597 Q-loop/lid; other site 272622004598 ABC transporter signature motif; other site 272622004599 Walker B; other site 272622004600 D-loop; other site 272622004601 H-loop/switch region; other site 272622004602 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 272622004603 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 272622004604 active site 272622004605 substrate binding site [chemical binding]; other site 272622004606 cosubstrate binding site; other site 272622004607 catalytic site [active] 272622004608 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 272622004609 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 272622004610 dimerization interface [polypeptide binding]; other site 272622004611 putative ATP binding site [chemical binding]; other site 272622004612 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 272622004613 Clp amino terminal domain; Region: Clp_N; pfam02861 272622004614 Clp amino terminal domain; Region: Clp_N; pfam02861 272622004615 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272622004616 Walker A motif; other site 272622004617 ATP binding site [chemical binding]; other site 272622004618 Walker B motif; other site 272622004619 arginine finger; other site 272622004620 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272622004621 Walker A motif; other site 272622004622 ATP binding site [chemical binding]; other site 272622004623 Walker B motif; other site 272622004624 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 272622004625 amidophosphoribosyltransferase; Provisional; Region: PRK07272 272622004626 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 272622004627 active site 272622004628 tetramer interface [polypeptide binding]; other site 272622004629 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 272622004630 active site 272622004631 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 272622004632 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 272622004633 dimerization interface [polypeptide binding]; other site 272622004634 ATP binding site [chemical binding]; other site 272622004635 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 272622004636 dimerization interface [polypeptide binding]; other site 272622004637 ATP binding site [chemical binding]; other site 272622004638 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 272622004639 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 272622004640 putative active site [active] 272622004641 catalytic triad [active] 272622004642 Phosphoribosylformylglycinamidine (FGAM) synthase, PurS component [Nucleotide transport and metabolism]; Region: PurS; COG1828 272622004643 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 272622004644 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 272622004645 ATP binding site [chemical binding]; other site 272622004646 active site 272622004647 substrate binding site [chemical binding]; other site 272622004648 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 272622004649 Uncharacterized conserved protein [Function unknown]; Region: COG1359 272622004650 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 272622004651 Uncharacterized protein conserved in bacteria (DUF2255); Region: DUF2255; cl01788 272622004652 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 272622004653 classical (c) SDRs; Region: SDR_c; cd05233 272622004654 NAD(P) binding site [chemical binding]; other site 272622004655 active site 272622004656 putative transporter; Provisional; Region: PRK10504 272622004657 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272622004658 putative substrate translocation pore; other site 272622004659 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272622004660 Transcriptional regulators [Transcription]; Region: MarR; COG1846 272622004661 MarR family; Region: MarR_2; pfam12802 272622004662 thymidylate synthase; Reviewed; Region: thyA; PRK01827 272622004663 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 272622004664 dimerization interface [polypeptide binding]; other site 272622004665 active site 272622004666 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272622004667 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 272622004668 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272622004669 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 272622004670 Transposase; Region: HTH_Tnp_1; pfam01527 272622004671 putative transposase OrfB; Reviewed; Region: PHA02517 272622004672 HTH-like domain; Region: HTH_21; pfam13276 272622004673 Integrase core domain; Region: rve; pfam00665 272622004674 Integrase core domain; Region: rve_3; pfam13683 272622004675 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 272622004676 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 272622004677 nucleotide binding site [chemical binding]; other site 272622004678 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 272622004679 beta-galactosidase; Region: BGL; TIGR03356 272622004680 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 272622004681 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 272622004682 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 272622004683 substrate binding site [chemical binding]; other site 272622004684 hexamer interface [polypeptide binding]; other site 272622004685 metal binding site [ion binding]; metal-binding site 272622004686 Transcriptional regulators [Transcription]; Region: PurR; COG1609 272622004687 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 272622004688 DNA binding site [nucleotide binding] 272622004689 domain linker motif; other site 272622004690 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 272622004691 ligand binding site [chemical binding]; other site 272622004692 dimerization interface [polypeptide binding]; other site 272622004693 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287 272622004694 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 272622004695 catalytic Zn binding site [ion binding]; other site 272622004696 NAD(P) binding site [chemical binding]; other site 272622004697 structural Zn binding site [ion binding]; other site 272622004698 Enterocin A Immunity; Region: EntA_Immun; pfam08951 272622004699 Predicted membrane protein [Function unknown]; Region: COG4905 272622004700 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 272622004701 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 272622004702 Dihydroorotate dehydrogenase (DHOD) class 1A FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1A_like; cd04741 272622004703 active site 272622004704 FMN binding site [chemical binding]; other site 272622004705 substrate binding site [chemical binding]; other site 272622004706 catalytic residues [active] 272622004707 homodimer interface [polypeptide binding]; other site 272622004708 Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225 272622004709 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 272622004710 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 272622004711 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 272622004712 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 272622004713 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272622004714 Walker A/P-loop; other site 272622004715 ATP binding site [chemical binding]; other site 272622004716 Q-loop/lid; other site 272622004717 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 272622004718 ABC transporter signature motif; other site 272622004719 Walker B; other site 272622004720 D-loop; other site 272622004721 ABC transporter; Region: ABC_tran_2; pfam12848 272622004722 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 272622004723 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272622004724 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272622004725 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 272622004726 dimerization interface [polypeptide binding]; other site 272622004727 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 272622004728 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 272622004729 putative active site [active] 272622004730 metal binding site [ion binding]; metal-binding site 272622004731 Dipeptidase [Amino acid transport and metabolism]; Region: PepD; COG4690 272622004732 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 272622004733 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 272622004734 active site 272622004735 NTP binding site [chemical binding]; other site 272622004736 metal binding triad [ion binding]; metal-binding site 272622004737 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 272622004738 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 272622004739 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 272622004740 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272622004741 Coenzyme A binding pocket [chemical binding]; other site 272622004742 dihydrodipicolinate reductase; Provisional; Region: PRK00048 272622004743 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 272622004744 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 272622004745 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DegV; COG1307 272622004746 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 272622004747 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4835 272622004748 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 272622004749 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 272622004750 RimM N-terminal domain; Region: RimM; pfam01782 272622004751 PRC-barrel domain; Region: PRC; pfam05239 272622004752 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 272622004753 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 272622004754 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 272622004755 Ferrochelatase; Region: Ferrochelatase; pfam00762 272622004756 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 272622004757 C-terminal domain interface [polypeptide binding]; other site 272622004758 active site 272622004759 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 272622004760 active site 272622004761 N-terminal domain interface [polypeptide binding]; other site 272622004762 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 272622004763 KH domain; Region: KH_4; pfam13083 272622004764 Ribosomal protein S16 [Translation, ribosomal structure and biogenesis]; Region: RpsP; COG0228 272622004765 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 272622004766 homodimer interface [polypeptide binding]; other site 272622004767 catalytic residues [active] 272622004768 NAD binding site [chemical binding]; other site 272622004769 substrate binding pocket [chemical binding]; other site 272622004770 flexible flap; other site 272622004771 putative acyltransferase; Provisional; Region: PRK05790 272622004772 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 272622004773 dimer interface [polypeptide binding]; other site 272622004774 active site 272622004775 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 272622004776 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 272622004777 dimer interface [polypeptide binding]; other site 272622004778 active site 272622004779 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 272622004780 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 272622004781 active site 272622004782 trimer interface [polypeptide binding]; other site 272622004783 allosteric site; other site 272622004784 active site lid [active] 272622004785 hexamer (dimer of trimers) interface [polypeptide binding]; other site 272622004786 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 272622004787 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 272622004788 Serine hydrolase (FSH1); Region: FSH1; pfam03959 272622004789 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 272622004790 Helix-turn-helix domain; Region: HTH_28; pfam13518 272622004791 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 272622004792 Homeodomain-like domain; Region: HTH_23; cl17451 272622004793 HTH-like domain; Region: HTH_21; pfam13276 272622004794 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 272622004795 Integrase core domain; Region: rve; pfam00665 272622004796 Integrase core domain; Region: rve_2; pfam13333 272622004797 putative transposase OrfB; Reviewed; Region: PHA02517 272622004798 HTH-like domain; Region: HTH_21; pfam13276 272622004799 Integrase core domain; Region: rve; pfam00665 272622004800 Integrase core domain; Region: rve_3; pfam13683 272622004801 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 272622004802 Transposase; Region: HTH_Tnp_1; pfam01527 272622004803 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 272622004804 Transposase; Region: HTH_Tnp_1; pfam01527 272622004805 putative transposase OrfB; Reviewed; Region: PHA02517 272622004806 HTH-like domain; Region: HTH_21; pfam13276 272622004807 Integrase core domain; Region: rve; pfam00665 272622004808 Integrase core domain; Region: rve_3; pfam13683 272622004809 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 272622004810 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 272622004811 active site 272622004812 DNA binding site [nucleotide binding] 272622004813 Int/Topo IB signature motif; other site 272622004814 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 272622004815 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 272622004816 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 272622004817 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 272622004818 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 272622004819 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 272622004820 putative active site [active] 272622004821 putative NTP binding site [chemical binding]; other site 272622004822 putative nucleic acid binding site [nucleotide binding]; other site 272622004823 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 272622004824 Type II intron maturase; Region: Intron_maturas2; pfam01348 272622004825 WxL domain surface cell wall-binding; Region: WxL; pfam13731 272622004826 WxL domain surface cell wall-binding; Region: WxL; pfam13731 272622004827 WxL domain surface cell wall-binding; Region: WxL; pfam13731 272622004828 WxL domain surface cell wall-binding; Region: WxL; pfam13731 272622004829 GTPase CgtA; Reviewed; Region: obgE; PRK12297 272622004830 GTP1/OBG; Region: GTP1_OBG; pfam01018 272622004831 Obg GTPase; Region: Obg; cd01898 272622004832 G1 box; other site 272622004833 GTP/Mg2+ binding site [chemical binding]; other site 272622004834 Switch I region; other site 272622004835 G2 box; other site 272622004836 G3 box; other site 272622004837 Switch II region; other site 272622004838 G4 box; other site 272622004839 G5 box; other site 272622004840 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 272622004841 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 272622004842 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 272622004843 Cell division protein FtsQ; Region: FtsQ; pfam03799 272622004844 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 272622004845 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 272622004846 homodimer interface [polypeptide binding]; other site 272622004847 active site 272622004848 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 272622004849 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002 272622004850 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 272622004851 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 272622004852 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 272622004853 Nitrogen regulatory protein P-II; Region: P-II; smart00938 272622004854 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 272622004855 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272622004856 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 272622004857 dimerization interface [polypeptide binding]; other site 272622004858 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272622004859 dimer interface [polypeptide binding]; other site 272622004860 phosphorylation site [posttranslational modification] 272622004861 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272622004862 ATP binding site [chemical binding]; other site 272622004863 Mg2+ binding site [ion binding]; other site 272622004864 G-X-G motif; other site 272622004865 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 272622004866 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272622004867 active site 272622004868 phosphorylation site [posttranslational modification] 272622004869 intermolecular recognition site; other site 272622004870 dimerization interface [polypeptide binding]; other site 272622004871 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272622004872 DNA binding site [nucleotide binding] 272622004873 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 272622004874 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 272622004875 conserved hypothetical protein; Region: TIGR02328 272622004876 Pyrimidine dimer DNA glycosylase; Region: Pyr_excise; pfam03013 272622004877 CHAP domain; Region: CHAP; pfam05257 272622004878 phosphodiesterase YaeI; Provisional; Region: PRK11340 272622004879 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 272622004880 putative active site [active] 272622004881 putative metal binding site [ion binding]; other site 272622004882 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 272622004883 Low molecular weight phosphatase family; Region: LMWPc; cd00115 272622004884 active site 272622004885 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 272622004886 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 272622004887 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 272622004888 catalytic site [active] 272622004889 subunit interface [polypeptide binding]; other site 272622004890 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 272622004891 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 272622004892 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 272622004893 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 272622004894 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 272622004895 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 272622004896 active site 272622004897 Peptidase M50B-like; Region: Peptidase_M50B; pfam13398 272622004898 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 272622004899 dimerization interface [polypeptide binding]; other site 272622004900 putative DNA binding site [nucleotide binding]; other site 272622004901 putative Zn2+ binding site [ion binding]; other site 272622004902 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 272622004903 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 272622004904 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 272622004905 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 272622004906 putative catalytic cysteine [active] 272622004907 Glutamate 5-kinase [Amino acid transport and metabolism]; Region: ProB; COG0263 272622004908 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 272622004909 nucleotide binding site [chemical binding]; other site 272622004910 homotetrameric interface [polypeptide binding]; other site 272622004911 putative phosphate binding site [ion binding]; other site 272622004912 putative allosteric binding site; other site 272622004913 Uncharacterized conserved protein [Function unknown]; Region: COG2461 272622004914 Family of unknown function (DUF438); Region: DUF438; pfam04282 272622004915 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 272622004916 Domain of unknown function (DUF1858); Region: DUF1858; pfam08984 272622004917 Predicted membrane protein [Function unknown]; Region: COG4392 272622004918 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 272622004919 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 272622004920 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 272622004921 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 272622004922 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 272622004923 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 272622004924 spermidine N1-acetyltransferase; Provisional; Region: PRK15130 272622004925 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272622004926 Coenzyme A binding pocket [chemical binding]; other site 272622004927 signal recognition particle protein; Provisional; Region: PRK10867 272622004928 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 272622004929 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 272622004930 P loop; other site 272622004931 GTP binding site [chemical binding]; other site 272622004932 Signal peptide binding domain; Region: SRP_SPB; pfam02978 272622004933 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 272622004934 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 272622004935 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 272622004936 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 272622004937 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 272622004938 MgtC family; Region: MgtC; pfam02308 272622004939 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 272622004940 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 272622004941 dimer interface [polypeptide binding]; other site 272622004942 active site 272622004943 catalytic residue [active] 272622004944 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 272622004945 nudix motif; other site 272622004946 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 272622004947 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 272622004948 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 272622004949 amphipathic channel; other site 272622004950 Asn-Pro-Ala signature motifs; other site 272622004951 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 272622004952 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 272622004953 TPP-binding site [chemical binding]; other site 272622004954 dimer interface [polypeptide binding]; other site 272622004955 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 272622004956 PYR/PP interface [polypeptide binding]; other site 272622004957 dimer interface [polypeptide binding]; other site 272622004958 TPP binding site [chemical binding]; other site 272622004959 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 272622004960 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 272622004961 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 272622004962 active site 272622004963 P-loop; other site 272622004964 phosphorylation site [posttranslational modification] 272622004965 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 272622004966 active site 272622004967 phosphorylation site [posttranslational modification] 272622004968 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 272622004969 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 272622004970 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 272622004971 PRD domain; Region: PRD; pfam00874 272622004972 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 272622004973 active site 272622004974 P-loop; other site 272622004975 phosphorylation site [posttranslational modification] 272622004976 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 272622004977 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 272622004978 active site 272622004979 intersubunit interface [polypeptide binding]; other site 272622004980 catalytic residue [active] 272622004981 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 272622004982 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 272622004983 substrate binding site [chemical binding]; other site 272622004984 ATP binding site [chemical binding]; other site 272622004985 Glucuronate isomerase; Region: UxaC; pfam02614 272622004986 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 272622004987 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 272622004988 active site 272622004989 catalytic residues [active] 272622004990 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 272622004991 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272622004992 putative substrate translocation pore; other site 272622004993 mannonate dehydratase; Provisional; Region: PRK03906 272622004994 mannonate dehydratase; Region: uxuA; TIGR00695 272622004995 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 272622004996 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 272622004997 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 272622004998 Transcriptional regulators [Transcription]; Region: GntR; COG1802 272622004999 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 272622005000 DNA-binding site [nucleotide binding]; DNA binding site 272622005001 FCD domain; Region: FCD; pfam07729 272622005002 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 272622005003 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272622005004 putative substrate translocation pore; other site 272622005005 Enterocin A Immunity; Region: EntA_Immun; pfam08951 272622005006 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 272622005007 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 272622005008 Cpl-1 lysin (also known as Cpl-9 lysozyme / muramidase) is a bacterial cell wall endolysin encoded by the pneumococcal bacteriophage Cp-1, which cleaves the glycosidic N-acetylmuramoyl-(beta1,4)-N-acetylglucosamine bonds of the pneumococcal glycan chain; Region: GH25_Cpl1-like; cd06415 272622005009 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 272622005010 active site 272622005011 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 272622005012 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 272622005013 Bacteriophage holin; Region: Phage_holin_1; pfam04531 272622005014 Domain of unknown function (DUF2479); Region: DUF2479; pfam10651 272622005015 Haemolysin XhlA; Region: XhlA; pfam10779 272622005016 Head domain of virus receptor-binding proteins (RBP); Region: RBP-H; cd07964 272622005017 trimer interface [polypeptide binding]; other site 272622005018 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 272622005019 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 272622005020 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 272622005021 Peptidase family M23; Region: Peptidase_M23; pfam01551 272622005022 putative phage tail component, N-terminal domain; Region: phi3626_gp14_N; TIGR01633 272622005023 tape measure domain; Region: tape_meas_nterm; TIGR02675 272622005024 Phage-related protein [Function unknown]; Region: COG5412 272622005025 Phage protein; Region: DUF3647; pfam12363 272622005026 phage major tail protein, TP901-1 family; Region: phgtail_TP901_1; TIGR02126 272622005027 Protein of unknown function (DUF3168); Region: DUF3168; pfam11367 272622005028 phage protein, HK97 gp10 family; Region: phge_HK97_gp10; TIGR01725 272622005029 Phage gp6-like head-tail connector protein; Region: Phage_connect_1; pfam05135 272622005030 HeH/LEM domain; Region: HeH; pfam12949 272622005031 Phage capsid family; Region: Phage_capsid; pfam05065 272622005032 Domain of unknown function (DUF4355); Region: DUF4355; pfam14265 272622005033 phage putative head morphogenesis protein, SPP1 gp7 family; Region: phageSPP1_gp7; TIGR01641 272622005034 phage portal protein, SPP1 family; Region: portal_SPP1; TIGR01538 272622005035 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 272622005036 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5410 272622005037 Terminase-like family; Region: Terminase_6; pfam03237 272622005038 Phage-related terminase [General function prediction only]; Region: COG5362; cl02216 272622005039 Terminase small subunit; Region: Terminase_2; cl01513 272622005040 Protein of unknown function (DUF722); Region: DUF722; pfam05263 272622005041 Protein of unknown function (DUF1359); Region: DUF1359; pfam07097 272622005042 Prophage protein (DUF1660); Region: DUF1660; pfam07874 272622005043 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 272622005044 trimer interface [polypeptide binding]; other site 272622005045 active site 272622005046 Protein of unknown function (DUF1642); Region: DUF1642; pfam07852 272622005047 Protein of unknown function (DUF1125); Region: DUF1125; pfam06563 272622005048 Protein of unknown function (DUF658); Region: DUF658; pfam04936 272622005049 Protein of unknown function (DUF658); Region: DUF658; pfam04936 272622005050 Protein of unknown function (DUF1497); Region: DUF1497; pfam07384 272622005051 Protein of unknown function (DUF1031); Region: DUF1031; pfam06275 272622005052 Holliday junction resolvase [DNA replication, recombination, and repair]; Region: Rus; COG4570 272622005053 Putative replisome organiser protein C-terminus; Region: Rep_Org_C; pfam06926 272622005054 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 272622005055 Transposase; Region: HTH_Tnp_1; pfam01527 272622005056 putative transposase OrfB; Reviewed; Region: PHA02517 272622005057 HTH-like domain; Region: HTH_21; pfam13276 272622005058 Integrase core domain; Region: rve; pfam00665 272622005059 Integrase core domain; Region: rve_3; pfam13683 272622005060 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 272622005061 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 272622005062 ligand binding site [chemical binding]; other site 272622005063 dimerization interface [polypeptide binding]; other site 272622005064 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 272622005065 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272622005066 Walker A/P-loop; other site 272622005067 ATP binding site [chemical binding]; other site 272622005068 Q-loop/lid; other site 272622005069 ABC transporter signature motif; other site 272622005070 Walker B; other site 272622005071 D-loop; other site 272622005072 H-loop/switch region; other site 272622005073 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 272622005074 D-ribose pyranase; Provisional; Region: PRK11797 272622005075 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 272622005076 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 272622005077 substrate binding site [chemical binding]; other site 272622005078 dimer interface [polypeptide binding]; other site 272622005079 ATP binding site [chemical binding]; other site 272622005080 Transcriptional regulators [Transcription]; Region: PurR; COG1609 272622005081 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 272622005082 DNA binding site [nucleotide binding] 272622005083 domain linker motif; other site 272622005084 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 272622005085 dimerization interface [polypeptide binding]; other site 272622005086 ligand binding site [chemical binding]; other site 272622005087 adenylosuccinate lyase; Provisional; Region: PRK07492 272622005088 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 272622005089 tetramer interface [polypeptide binding]; other site 272622005090 active site 272622005091 Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998 272622005092 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 272622005093 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 272622005094 active site 272622005095 catalytic residue [active] 272622005096 dimer interface [polypeptide binding]; other site 272622005097 Protein of unknown function (DUF2969); Region: DUF2969; pfam11184 272622005098 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 272622005099 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 272622005100 catalytic residues [active] 272622005101 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 272622005102 MutS domain III; Region: MutS_III; pfam05192 272622005103 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 272622005104 Walker A/P-loop; other site 272622005105 ATP binding site [chemical binding]; other site 272622005106 Q-loop/lid; other site 272622005107 ABC transporter signature motif; other site 272622005108 Walker B; other site 272622005109 D-loop; other site 272622005110 H-loop/switch region; other site 272622005111 Smr domain; Region: Smr; pfam01713 272622005112 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 272622005113 Colicin V production protein; Region: Colicin_V; pfam02674 272622005114 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 272622005115 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 272622005116 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 272622005117 catabolite control protein A; Region: ccpA; TIGR01481 272622005118 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 272622005119 DNA binding site [nucleotide binding] 272622005120 domain linker motif; other site 272622005121 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 272622005122 dimerization interface [polypeptide binding]; other site 272622005123 effector binding site; other site 272622005124 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 272622005125 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 272622005126 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 272622005127 active site 272622005128 AAA ATPase containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: MDN1; COG5271 272622005129 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 272622005130 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 272622005131 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 272622005132 cell division protein GpsB; Provisional; Region: PRK14127 272622005133 DivIVA domain; Region: DivI1A_domain; TIGR03544 272622005134 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 272622005135 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 272622005136 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 272622005137 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 272622005138 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 272622005139 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 272622005140 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272622005141 active site 272622005142 motif I; other site 272622005143 motif II; other site 272622005144 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 272622005145 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 272622005146 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 272622005147 ATP-binding site [chemical binding]; other site 272622005148 Sugar specificity; other site 272622005149 Pyrimidine base specificity; other site 272622005150 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 272622005151 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 272622005152 Cpl-7 lysozyme C-terminal domain; Region: Cpl-7; smart01095 272622005153 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 272622005154 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Provisional; Region: PRK13387 272622005155 UbiA prenyltransferase family; Region: UbiA; pfam01040 272622005156 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 272622005157 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 272622005158 Cl- selectivity filter; other site 272622005159 Cl- binding residues [ion binding]; other site 272622005160 pore gating glutamate residue; other site 272622005161 dimer interface [polypeptide binding]; other site 272622005162 H+/Cl- coupling transport residue; other site 272622005163 TrkA-C domain; Region: TrkA_C; pfam02080 272622005164 Enterocin A Immunity; Region: EntA_Immun; pfam08951 272622005165 Lactococcin-like family; Region: Lactococcin; pfam04369 272622005166 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272622005167 non-specific DNA binding site [nucleotide binding]; other site 272622005168 salt bridge; other site 272622005169 sequence-specific DNA binding site [nucleotide binding]; other site 272622005170 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 272622005171 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 272622005172 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272622005173 S-adenosylmethionine binding site [chemical binding]; other site 272622005174 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 272622005175 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 272622005176 Uncharacterized conserved protein [Function unknown]; Region: COG0759 272622005177 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK12315 272622005178 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 272622005179 TPP-binding site; other site 272622005180 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 272622005181 PYR/PP interface [polypeptide binding]; other site 272622005182 dimer interface [polypeptide binding]; other site 272622005183 TPP binding site [chemical binding]; other site 272622005184 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 272622005185 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272622005186 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272622005187 dimer interface [polypeptide binding]; other site 272622005188 phosphorylation site [posttranslational modification] 272622005189 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272622005190 ATP binding site [chemical binding]; other site 272622005191 Mg2+ binding site [ion binding]; other site 272622005192 G-X-G motif; other site 272622005193 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 272622005194 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272622005195 active site 272622005196 phosphorylation site [posttranslational modification] 272622005197 intermolecular recognition site; other site 272622005198 dimerization interface [polypeptide binding]; other site 272622005199 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272622005200 DNA binding site [nucleotide binding] 272622005201 Transcriptional regulators [Transcription]; Region: PurR; COG1609 272622005202 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 272622005203 DNA binding site [nucleotide binding] 272622005204 domain linker motif; other site 272622005205 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 272622005206 putative dimerization interface [polypeptide binding]; other site 272622005207 putative ligand binding site [chemical binding]; other site 272622005208 maltose phosphorylase; Provisional; Region: PRK13807 272622005209 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 272622005210 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 272622005211 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 272622005212 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 272622005213 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 272622005214 Ca binding site [ion binding]; other site 272622005215 active site 272622005216 catalytic site [active] 272622005217 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 272622005218 Alpha amylase catalytic domain found in bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac2_AmyA; cd11316 272622005219 Ca binding site [ion binding]; other site 272622005220 active site 272622005221 catalytic site [active] 272622005222 maltose O-acetyltransferase; Provisional; Region: PRK10092 272622005223 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 272622005224 active site 272622005225 substrate binding site [chemical binding]; other site 272622005226 trimer interface [polypeptide binding]; other site 272622005227 CoA binding site [chemical binding]; other site 272622005228 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 272622005229 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 272622005230 Ca binding site [ion binding]; other site 272622005231 active site 272622005232 catalytic site [active] 272622005233 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 272622005234 homodimer interface [polypeptide binding]; other site 272622005235 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 272622005236 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 272622005237 active site 272622005238 homodimer interface [polypeptide binding]; other site 272622005239 catalytic site [active] 272622005240 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 272622005241 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 272622005242 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272622005243 dimer interface [polypeptide binding]; other site 272622005244 conserved gate region; other site 272622005245 putative PBP binding loops; other site 272622005246 ABC-ATPase subunit interface; other site 272622005247 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 272622005248 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272622005249 dimer interface [polypeptide binding]; other site 272622005250 conserved gate region; other site 272622005251 putative PBP binding loops; other site 272622005252 ABC-ATPase subunit interface; other site 272622005253 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 272622005254 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 272622005255 Isochorismatase family; Region: Isochorismatase; pfam00857 272622005256 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 272622005257 catalytic triad [active] 272622005258 dimer interface [polypeptide binding]; other site 272622005259 conserved cis-peptide bond; other site 272622005260 Transcriptional regulator [Transcription]; Region: LytR; COG1316 272622005261 cytidylate kinase; Provisional; Region: cmk; PRK00023 272622005262 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 272622005263 CMP-binding site; other site 272622005264 The sites determining sugar specificity; other site 272622005265 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 272622005266 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 272622005267 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 272622005268 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 272622005269 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 272622005270 active pocket/dimerization site; other site 272622005271 active site 272622005272 phosphorylation site [posttranslational modification] 272622005273 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 272622005274 active site 272622005275 phosphorylation site [posttranslational modification] 272622005276 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 272622005277 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 272622005278 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4687 272622005279 Uncharacterized conserved protein [Function unknown]; Region: COG1284 272622005280 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 272622005281 Domain of unknown function (DUF956); Region: DUF956; cl01917 272622005282 seryl-tRNA synthetase; Provisional; Region: PRK05431 272622005283 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 272622005284 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 272622005285 dimer interface [polypeptide binding]; other site 272622005286 active site 272622005287 motif 1; other site 272622005288 motif 2; other site 272622005289 motif 3; other site 272622005290 putative transposase OrfB; Reviewed; Region: PHA02517 272622005291 HTH-like domain; Region: HTH_21; pfam13276 272622005292 Integrase core domain; Region: rve; pfam00665 272622005293 Integrase core domain; Region: rve_3; pfam13683 272622005294 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 272622005295 Transposase; Region: HTH_Tnp_1; pfam01527 272622005296 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 272622005297 putative dimer interface [polypeptide binding]; other site 272622005298 catalytic triad [active] 272622005299 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 272622005300 catalytic core [active] 272622005301 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 272622005302 PhoU domain; Region: PhoU; pfam01895 272622005303 PhoU domain; Region: PhoU; pfam01895 272622005304 phosphate transporter ATP-binding protein; Provisional; Region: PRK14239 272622005305 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 272622005306 Walker A/P-loop; other site 272622005307 ATP binding site [chemical binding]; other site 272622005308 Q-loop/lid; other site 272622005309 ABC transporter signature motif; other site 272622005310 Walker B; other site 272622005311 D-loop; other site 272622005312 H-loop/switch region; other site 272622005313 phosphate transporter ATP-binding protein; Provisional; Region: PRK14237 272622005314 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 272622005315 Walker A/P-loop; other site 272622005316 ATP binding site [chemical binding]; other site 272622005317 Q-loop/lid; other site 272622005318 ABC transporter signature motif; other site 272622005319 Walker B; other site 272622005320 D-loop; other site 272622005321 H-loop/switch region; other site 272622005322 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 272622005323 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272622005324 dimer interface [polypeptide binding]; other site 272622005325 conserved gate region; other site 272622005326 putative PBP binding loops; other site 272622005327 ABC-ATPase subunit interface; other site 272622005328 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 272622005329 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272622005330 dimer interface [polypeptide binding]; other site 272622005331 conserved gate region; other site 272622005332 putative PBP binding loops; other site 272622005333 ABC-ATPase subunit interface; other site 272622005334 PBP superfamily domain; Region: PBP_like_2; cl17296 272622005335 PBP superfamily domain; Region: PBP_like_2; cl17296 272622005336 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 272622005337 SmpB-tmRNA interface; other site 272622005338 Predicted transcriptional regulators [Transcription]; Region: COG1733 272622005339 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 272622005340 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 272622005341 dimer interface [polypeptide binding]; other site 272622005342 FMN binding site [chemical binding]; other site 272622005343 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 272622005344 active site 272622005345 catalytic triad [active] 272622005346 oxyanion hole [active] 272622005347 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 272622005348 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 272622005349 motif 1; other site 272622005350 active site 272622005351 motif 2; other site 272622005352 motif 3; other site 272622005353 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 272622005354 DHHA1 domain; Region: DHHA1; pfam02272 272622005355 foldase protein PrsA; Reviewed; Region: PRK12450 272622005356 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 272622005357 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272622005358 S-adenosylmethionine binding site [chemical binding]; other site 272622005359 Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164 272622005360 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 272622005361 active site 272622005362 Zn binding site [ion binding]; other site 272622005363 Competence protein CoiA-like family; Region: CoiA; cl11541 272622005364 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 272622005365 putative active site [active] 272622005366 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 272622005367 Sulfate transporter family; Region: Sulfate_transp; pfam00916 272622005368 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272622005369 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 272622005370 active site 272622005371 motif I; other site 272622005372 motif II; other site 272622005373 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 272622005374 CoB--CoM heterodisulfide reductase, subunit B; Region: CoB_CoM_SS_B; TIGR03288 272622005375 Cysteine-rich domain; Region: CCG; pfam02754 272622005376 Cysteine-rich domain; Region: CCG; pfam02754 272622005377 Uncharacterized conserved protein [Function unknown]; Region: COG1556 272622005378 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 272622005379 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 272622005380 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 272622005381 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 272622005382 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 272622005383 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 272622005384 Zn2+ binding site [ion binding]; other site 272622005385 Mg2+ binding site [ion binding]; other site 272622005386 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 272622005387 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 272622005388 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 272622005389 AAA domain; Region: AAA_30; pfam13604 272622005390 Family description; Region: UvrD_C_2; pfam13538 272622005391 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 272622005392 catalytic core [active] 272622005393 prephenate dehydratase; Provisional; Region: PRK11898 272622005394 Prephenate dehydratase; Region: PDT; pfam00800 272622005395 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 272622005396 putative L-Phe binding site [chemical binding]; other site 272622005397 shikimate kinase; Reviewed; Region: aroK; PRK00131 272622005398 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 272622005399 ADP binding site [chemical binding]; other site 272622005400 magnesium binding site [ion binding]; other site 272622005401 putative shikimate binding site; other site 272622005402 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 272622005403 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 272622005404 hinge; other site 272622005405 active site 272622005406 prephenate dehydrogenase; Validated; Region: PRK06545 272622005407 prephenate dehydrogenase; Validated; Region: PRK08507 272622005408 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 272622005409 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272622005410 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272622005411 ATP binding site [chemical binding]; other site 272622005412 Mg2+ binding site [ion binding]; other site 272622005413 G-X-G motif; other site 272622005414 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 272622005415 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272622005416 active site 272622005417 phosphorylation site [posttranslational modification] 272622005418 intermolecular recognition site; other site 272622005419 dimerization interface [polypeptide binding]; other site 272622005420 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272622005421 DNA binding site [nucleotide binding] 272622005422 Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767 272622005423 FtsX-like permease family; Region: FtsX; pfam02687 272622005424 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 272622005425 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 272622005426 Walker A/P-loop; other site 272622005427 ATP binding site [chemical binding]; other site 272622005428 Q-loop/lid; other site 272622005429 ABC transporter signature motif; other site 272622005430 Walker B; other site 272622005431 D-loop; other site 272622005432 H-loop/switch region; other site 272622005433 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5294 272622005434 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 272622005435 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 272622005436 Tetramer interface [polypeptide binding]; other site 272622005437 active site 272622005438 FMN-binding site [chemical binding]; other site 272622005439 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 272622005440 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272622005441 motif II; other site 272622005442 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493 272622005443 Protein of unknown function (DUF1054); Region: DUF1054; pfam06335 272622005444 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 272622005445 Protein of unknown function, DUF606; Region: DUF606; pfam04657 272622005446 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 272622005447 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 272622005448 active site 272622005449 dimer interface [polypeptide binding]; other site 272622005450 metal binding site [ion binding]; metal-binding site 272622005451 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 272622005452 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 272622005453 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 272622005454 shikimate binding site; other site 272622005455 NAD(P) binding site [chemical binding]; other site 272622005456 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 272622005457 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 272622005458 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 272622005459 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 272622005460 substrate binding pocket [chemical binding]; other site 272622005461 membrane-bound complex binding site; other site 272622005462 hinge residues; other site 272622005463 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 272622005464 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 272622005465 substrate binding pocket [chemical binding]; other site 272622005466 membrane-bound complex binding site; other site 272622005467 hinge residues; other site 272622005468 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 272622005469 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272622005470 dimer interface [polypeptide binding]; other site 272622005471 conserved gate region; other site 272622005472 putative PBP binding loops; other site 272622005473 ABC-ATPase subunit interface; other site 272622005474 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 272622005475 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 272622005476 Walker A/P-loop; other site 272622005477 ATP binding site [chemical binding]; other site 272622005478 Q-loop/lid; other site 272622005479 ABC transporter signature motif; other site 272622005480 Walker B; other site 272622005481 D-loop; other site 272622005482 H-loop/switch region; other site 272622005483 putative transposase OrfB; Reviewed; Region: PHA02517 272622005484 HTH-like domain; Region: HTH_21; pfam13276 272622005485 Integrase core domain; Region: rve; pfam00665 272622005486 Integrase core domain; Region: rve_3; pfam13683 272622005487 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 272622005488 Transposase; Region: HTH_Tnp_1; pfam01527 272622005489 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 272622005490 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 272622005491 gamma subunit interface [polypeptide binding]; other site 272622005492 epsilon subunit interface [polypeptide binding]; other site 272622005493 LBP interface [polypeptide binding]; other site 272622005494 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 272622005495 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 272622005496 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 272622005497 alpha subunit interaction interface [polypeptide binding]; other site 272622005498 Walker A motif; other site 272622005499 ATP binding site [chemical binding]; other site 272622005500 Walker B motif; other site 272622005501 inhibitor binding site; inhibition site 272622005502 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 272622005503 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 272622005504 core domain interface [polypeptide binding]; other site 272622005505 delta subunit interface [polypeptide binding]; other site 272622005506 epsilon subunit interface [polypeptide binding]; other site 272622005507 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 272622005508 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 272622005509 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 272622005510 beta subunit interaction interface [polypeptide binding]; other site 272622005511 Walker A motif; other site 272622005512 ATP binding site [chemical binding]; other site 272622005513 Walker B motif; other site 272622005514 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 272622005515 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 272622005516 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 272622005517 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 272622005518 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 272622005519 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 272622005520 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 272622005521 F0F1 ATP synthase subunit C; Provisional; Region: PRK13466 272622005522 Predicted esterase [General function prediction only]; Region: COG0627 272622005523 S-formylglutathione hydrolase; Region: PLN02442 272622005524 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 272622005525 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 272622005526 SLBB domain; Region: SLBB; pfam10531 272622005527 comEA protein; Region: comE; TIGR01259 272622005528 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 272622005529 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 272622005530 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 272622005531 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 272622005532 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272622005533 Walker A/P-loop; other site 272622005534 ATP binding site [chemical binding]; other site 272622005535 Q-loop/lid; other site 272622005536 ABC transporter signature motif; other site 272622005537 Walker B; other site 272622005538 D-loop; other site 272622005539 H-loop/switch region; other site 272622005540 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 272622005541 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 272622005542 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 272622005543 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 272622005544 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 272622005545 transmembrane helices; other site 272622005546 Putative transcription activator [Transcription]; Region: TenA; COG0819 272622005547 Zinc finger domain containing protein (CHY type) [Function unknown]; Region: COG4357 272622005548 CHY zinc finger; Region: zf-CHY; pfam05495 272622005549 Biotin operon repressor [Transcription]; Region: BirA; COG1654 272622005550 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 272622005551 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 272622005552 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 272622005553 BioY family; Region: BioY; pfam02632 272622005554 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 272622005555 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 272622005556 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 272622005557 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 272622005558 acyl-activating enzyme (AAE) consensus motif; other site 272622005559 AMP binding site [chemical binding]; other site 272622005560 active site 272622005561 CoA binding site [chemical binding]; other site 272622005562 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 272622005563 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 272622005564 dimer interface [polypeptide binding]; other site 272622005565 active site 272622005566 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 272622005567 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272622005568 active site 272622005569 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 272622005570 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 272622005571 FMN binding site [chemical binding]; other site 272622005572 substrate binding site [chemical binding]; other site 272622005573 putative catalytic residue [active] 272622005574 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 272622005575 type VII secretion protein EsaA, N-terminal domain; Region: T7_esaA_Nterm; TIGR03929 272622005576 Enterocin A Immunity; Region: EntA_Immun; pfam08951 272622005577 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 272622005578 Transposase; Region: HTH_Tnp_1; pfam01527 272622005579 putative transposase OrfB; Reviewed; Region: PHA02517 272622005580 HTH-like domain; Region: HTH_21; pfam13276 272622005581 Integrase core domain; Region: rve; pfam00665 272622005582 Integrase core domain; Region: rve_3; pfam13683 272622005583 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 272622005584 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 272622005585 FeS assembly protein SufB; Region: sufB; TIGR01980 272622005586 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 272622005587 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 272622005588 trimerization site [polypeptide binding]; other site 272622005589 active site 272622005590 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 272622005591 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 272622005592 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 272622005593 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 272622005594 catalytic residue [active] 272622005595 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 272622005596 FeS assembly protein SufD; Region: sufD; TIGR01981 272622005597 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 272622005598 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 272622005599 Walker A/P-loop; other site 272622005600 ATP binding site [chemical binding]; other site 272622005601 Q-loop/lid; other site 272622005602 ABC transporter signature motif; other site 272622005603 Walker B; other site 272622005604 D-loop; other site 272622005605 H-loop/switch region; other site 272622005606 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 272622005607 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 272622005608 Mg++ binding site [ion binding]; other site 272622005609 putative catalytic motif [active] 272622005610 substrate binding site [chemical binding]; other site 272622005611 Negative regulator of genetic competence, sporulation and motility [Posttranslational modification, protein turnover, chaperones / Signal transduction mechanisms / Cell motility and secretion]; Region: MecA; COG4862 272622005612 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 272622005613 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 272622005614 Walker A/P-loop; other site 272622005615 ATP binding site [chemical binding]; other site 272622005616 Q-loop/lid; other site 272622005617 ABC transporter signature motif; other site 272622005618 Walker B; other site 272622005619 D-loop; other site 272622005620 H-loop/switch region; other site 272622005621 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 272622005622 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272622005623 dimer interface [polypeptide binding]; other site 272622005624 conserved gate region; other site 272622005625 putative PBP binding loops; other site 272622005626 ABC-ATPase subunit interface; other site 272622005627 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 272622005628 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 272622005629 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 272622005630 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 272622005631 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 272622005632 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 272622005633 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 272622005634 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 272622005635 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 272622005636 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 272622005637 G-loop; other site 272622005638 DNA binding site [nucleotide binding] 272622005639 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 272622005640 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 272622005641 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 272622005642 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 272622005643 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 272622005644 RPB1 interaction site [polypeptide binding]; other site 272622005645 RPB10 interaction site [polypeptide binding]; other site 272622005646 RPB11 interaction site [polypeptide binding]; other site 272622005647 RPB3 interaction site [polypeptide binding]; other site 272622005648 RPB12 interaction site [polypeptide binding]; other site 272622005649 CodY GAF-like domain; Region: CodY; pfam06018 272622005650 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 272622005651 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 272622005652 non-specific DNA binding site [nucleotide binding]; other site 272622005653 salt bridge; other site 272622005654 sequence-specific DNA binding site [nucleotide binding]; other site 272622005655 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 272622005656 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 272622005657 active site 272622005658 Zn binding site [ion binding]; other site 272622005659 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 272622005660 active site 272622005661 DNA binding site [nucleotide binding] 272622005662 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 272622005663 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 272622005664 UDP-N-acetylmuramoylalanyl-D-glutamate--L-lysine ligase; Provisional; Region: PRK14022 272622005665 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 272622005666 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 272622005667 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 272622005668 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 272622005669 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 272622005670 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 272622005671 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 272622005672 NAD binding site [chemical binding]; other site 272622005673 substrate binding site [chemical binding]; other site 272622005674 catalytic Zn binding site [ion binding]; other site 272622005675 tetramer interface [polypeptide binding]; other site 272622005676 structural Zn binding site [ion binding]; other site 272622005677 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 272622005678 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272622005679 ATP binding site [chemical binding]; other site 272622005680 putative Mg++ binding site [ion binding]; other site 272622005681 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272622005682 nucleotide binding region [chemical binding]; other site 272622005683 ATP-binding site [chemical binding]; other site 272622005684 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 272622005685 HRDC domain; Region: HRDC; pfam00570 272622005686 putative transposase OrfB; Reviewed; Region: PHA02517 272622005687 HTH-like domain; Region: HTH_21; pfam13276 272622005688 Integrase core domain; Region: rve; pfam00665 272622005689 Integrase core domain; Region: rve_3; pfam13683 272622005690 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 272622005691 Transposase; Region: HTH_Tnp_1; pfam01527 272622005692 inner membrane transporter YjeM; Provisional; Region: PRK15238 272622005693 peptidase T; Region: peptidase-T; TIGR01882 272622005694 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 272622005695 metal binding site [ion binding]; metal-binding site 272622005696 dimer interface [polypeptide binding]; other site 272622005697 Domain of unknown function (DUF1803); Region: DUF1803; pfam08820 272622005698 Domain of unknown function (DUF1803); Region: DUF1803; pfam08820 272622005699 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 272622005700 DHH family; Region: DHH; pfam01368 272622005701 DHHA2 domain; Region: DHHA2; pfam02833 272622005702 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 272622005703 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272622005704 FeS/SAM binding site; other site 272622005705 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 272622005706 Domain of unknown function DUF21; Region: DUF21; pfam01595 272622005707 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 272622005708 Transporter associated domain; Region: CorC_HlyC; smart01091 272622005709 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 272622005710 Domain of unknown function DUF20; Region: UPF0118; pfam01594 272622005711 Transcriptional regulator; Region: Rrf2; pfam02082 272622005712 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272622005713 Coenzyme A binding pocket [chemical binding]; other site 272622005714 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 272622005715 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 272622005716 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 272622005717 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 272622005718 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033 272622005719 putative uracil binding site [chemical binding]; other site 272622005720 putative active site [active] 272622005721 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 272622005722 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 272622005723 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 272622005724 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 272622005725 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 272622005726 GIY-YIG motif/motif A; other site 272622005727 putative active site [active] 272622005728 putative metal binding site [ion binding]; other site 272622005729 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 272622005730 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 272622005731 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 272622005732 Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564 272622005733 Thiamine pyrophosphokinase; Region: TPK; cd07995 272622005734 active site 272622005735 dimerization interface [polypeptide binding]; other site 272622005736 thiamine binding site [chemical binding]; other site 272622005737 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u4; cd11541 272622005738 putative metal binding site [ion binding]; other site 272622005739 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 272622005740 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 272622005741 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 272622005742 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 272622005743 putative dimer interface [polypeptide binding]; other site 272622005744 putative anticodon binding site; other site 272622005745 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 272622005746 homodimer interface [polypeptide binding]; other site 272622005747 motif 1; other site 272622005748 motif 2; other site 272622005749 active site 272622005750 motif 3; other site 272622005751 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 272622005752 GIY-YIG motif/motif A; other site 272622005753 active site 272622005754 catalytic site [active] 272622005755 metal binding site [ion binding]; metal-binding site 272622005756 aspartate aminotransferase; Provisional; Region: PRK05764 272622005757 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 272622005758 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272622005759 homodimer interface [polypeptide binding]; other site 272622005760 catalytic residue [active] 272622005761 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 272622005762 DnaQ family exonuclease/DinG family helicase, putative; Region: dinG_rel; TIGR01407 272622005763 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 272622005764 active site 272622005765 catalytic site [active] 272622005766 substrate binding site [chemical binding]; other site 272622005767 DEAD/DEAH box helicase; Region: DEAD; pfam00270 272622005768 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 272622005769 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 272622005770 Ligand Binding Site [chemical binding]; other site 272622005771 The substrate binding component of an ABC-type lactococcal OppA-like transport system contains; Region: PBP2_Lactococcal_OppA_like; cd08510 272622005772 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 272622005773 peptide binding site [polypeptide binding]; other site 272622005774 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 272622005775 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272622005776 dimer interface [polypeptide binding]; other site 272622005777 conserved gate region; other site 272622005778 putative PBP binding loops; other site 272622005779 ABC-ATPase subunit interface; other site 272622005780 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 272622005781 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272622005782 dimer interface [polypeptide binding]; other site 272622005783 conserved gate region; other site 272622005784 putative PBP binding loops; other site 272622005785 ABC-ATPase subunit interface; other site 272622005786 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 272622005787 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 272622005788 Walker A/P-loop; other site 272622005789 ATP binding site [chemical binding]; other site 272622005790 Q-loop/lid; other site 272622005791 ABC transporter signature motif; other site 272622005792 Walker B; other site 272622005793 D-loop; other site 272622005794 H-loop/switch region; other site 272622005795 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 272622005796 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 272622005797 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 272622005798 Walker A/P-loop; other site 272622005799 ATP binding site [chemical binding]; other site 272622005800 Q-loop/lid; other site 272622005801 ABC transporter signature motif; other site 272622005802 Walker B; other site 272622005803 D-loop; other site 272622005804 H-loop/switch region; other site 272622005805 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 272622005806 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 272622005807 23S rRNA binding site [nucleotide binding]; other site 272622005808 L21 binding site [polypeptide binding]; other site 272622005809 L13 binding site [polypeptide binding]; other site 272622005810 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 272622005811 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 272622005812 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 272622005813 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 272622005814 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 272622005815 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 272622005816 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 272622005817 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272622005818 motif II; other site 272622005819 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 272622005820 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 272622005821 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 272622005822 Protein of unknown function (DUF1033); Region: DUF1033; pfam06279 272622005823 Ribonuclease III family protein [Replication, recombination, and repair]; Region: COG1939 272622005824 active site 272622005825 metal binding site [ion binding]; metal-binding site 272622005826 dimerization interface [polypeptide binding]; other site 272622005827 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 272622005828 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 272622005829 active site 272622005830 HIGH motif; other site 272622005831 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 272622005832 KMSKS motif; other site 272622005833 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 272622005834 tRNA binding surface [nucleotide binding]; other site 272622005835 anticodon binding site; other site 272622005836 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 272622005837 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 272622005838 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 272622005839 trimer interface [polypeptide binding]; other site 272622005840 active site 272622005841 substrate binding site [chemical binding]; other site 272622005842 CoA binding site [chemical binding]; other site 272622005843 Domain of unknown function (DUF4343); Region: DUF4343; pfam14243 272622005844 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 272622005845 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 272622005846 RNase E interface [polypeptide binding]; other site 272622005847 trimer interface [polypeptide binding]; other site 272622005848 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 272622005849 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 272622005850 RNase E interface [polypeptide binding]; other site 272622005851 trimer interface [polypeptide binding]; other site 272622005852 active site 272622005853 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 272622005854 putative nucleic acid binding region [nucleotide binding]; other site 272622005855 G-X-X-G motif; other site 272622005856 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 272622005857 RNA binding site [nucleotide binding]; other site 272622005858 domain interface; other site 272622005859 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02458 272622005860 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 272622005861 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 272622005862 active site 272622005863 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 272622005864 Ligand Binding Site [chemical binding]; other site 272622005865 Putative amino acid metabolism; Region: DUF1831; pfam08866 272622005866 elongation factor Tu; Reviewed; Region: PRK00049 272622005867 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 272622005868 G1 box; other site 272622005869 GEF interaction site [polypeptide binding]; other site 272622005870 GTP/Mg2+ binding site [chemical binding]; other site 272622005871 Switch I region; other site 272622005872 G2 box; other site 272622005873 G3 box; other site 272622005874 Switch II region; other site 272622005875 G4 box; other site 272622005876 G5 box; other site 272622005877 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 272622005878 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 272622005879 Antibiotic Binding Site [chemical binding]; other site 272622005880 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 272622005881 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 272622005882 active site 272622005883 HIGH motif; other site 272622005884 nucleotide binding site [chemical binding]; other site 272622005885 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 272622005886 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 272622005887 active site 272622005888 KMSKS motif; other site 272622005889 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 272622005890 tRNA binding surface [nucleotide binding]; other site 272622005891 anticodon binding site; other site 272622005892 DivIVA protein; Region: DivIVA; pfam05103 272622005893 DivIVA domain; Region: DivI1A_domain; TIGR03544 272622005894 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 272622005895 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 272622005896 RNA binding surface [nucleotide binding]; other site 272622005897 YGGT family; Region: YGGT; pfam02325 272622005898 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 272622005899 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 272622005900 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 272622005901 catalytic residue [active] 272622005902 cell division protein FtsZ; Validated; Region: PRK09330 272622005903 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 272622005904 nucleotide binding site [chemical binding]; other site 272622005905 SulA interaction site; other site 272622005906 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 272622005907 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 272622005908 nucleotide binding site [chemical binding]; other site 272622005909 Cell division protein FtsA; Region: FtsA; pfam14450 272622005910 Domain of unknown function (DUF3484); Region: DUF3484; pfam11983 272622005911 EDD domain protein, DegV family; Region: DegV; TIGR00762 272622005912 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 272622005913 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 272622005914 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 272622005915 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 272622005916 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 272622005917 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 272622005918 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 272622005919 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 272622005920 active site 272622005921 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 272622005922 catalytic tetrad [active] 272622005923 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272622005924 putative substrate translocation pore; other site 272622005925 Major Facilitator Superfamily; Region: MFS_1; pfam07690 272622005926 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272622005927 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 272622005928 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 272622005929 DNA binding residues [nucleotide binding] 272622005930 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 272622005931 trimer interface [polypeptide binding]; other site 272622005932 active site 272622005933 G bulge; other site 272622005934 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 272622005935 Zn2+ binding site [ion binding]; other site 272622005936 Mg2+ binding site [ion binding]; other site 272622005937 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 272622005938 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 272622005939 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 272622005940 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 272622005941 dimer interface [polypeptide binding]; other site 272622005942 ADP-ribose binding site [chemical binding]; other site 272622005943 active site 272622005944 nudix motif; other site 272622005945 metal binding site [ion binding]; metal-binding site 272622005946 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 272622005947 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 272622005948 Substrate binding site; other site 272622005949 Mg++ binding site; other site 272622005950 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 272622005951 active site 272622005952 substrate binding site [chemical binding]; other site 272622005953 CoA binding site [chemical binding]; other site 272622005954 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 272622005955 pyrroline-5-carboxylate reductase; Region: PLN02688 272622005956 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 272622005957 16S/18S rRNA binding site [nucleotide binding]; other site 272622005958 S13e-L30e interaction site [polypeptide binding]; other site 272622005959 25S rRNA binding site [nucleotide binding]; other site 272622005960 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 272622005961 Catalytic domain of Protein Kinases; Region: PKc; cd00180 272622005962 active site 272622005963 ATP binding site [chemical binding]; other site 272622005964 substrate binding site [chemical binding]; other site 272622005965 activation loop (A-loop); other site 272622005966 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 272622005967 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 272622005968 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768 272622005969 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 272622005970 active site 272622005971 16S rRNA methyltransferase B; Provisional; Region: PRK14902 272622005972 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 272622005973 putative RNA binding site [nucleotide binding]; other site 272622005974 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272622005975 S-adenosylmethionine binding site [chemical binding]; other site 272622005976 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 272622005977 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 272622005978 Ligand binding site; other site 272622005979 Putative Catalytic site; other site 272622005980 DXD motif; other site 272622005981 conserved hypothetical integral membrane protein; Region: TIGR03766 272622005982 holin, SPP1 family; Region: holin_SPP1; TIGR01592 272622005983 Bacteriophage peptidoglycan hydrolase; Region: Amidase_5; pfam05382 272622005984 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 272622005985 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 272622005986 TPR/MLP1/MLP2-like protein; Region: TPR_MLP1_2; pfam07926 272622005987 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 272622005988 N-acetyl-D-glucosamine binding site [chemical binding]; other site 272622005989 catalytic residue [active] 272622005990 Phage tail protein; Region: Phage_tail_3; pfam08813 272622005991 Head-Tail Connector Protein gp15 of Bacteriophage SPP1 and similar proteins; Region: gp15; cd08055 272622005992 Phage capsid family; Region: Phage_capsid; pfam05065 272622005993 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 272622005994 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 272622005995 Domain of unknown function (DUF4355); Region: DUF4355; pfam14265 272622005996 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 272622005997 hypothetical protein; Provisional; Region: PRK14553 272622005998 phage portal protein, SPP1 family; Region: portal_SPP1; TIGR01538 272622005999 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 272622006000 Phage terminase large subunit; Region: Terminase_3; cl12054 272622006001 Terminase small subunit; Region: Terminase_2; pfam03592 272622006002 Protein of unknown function (DUF722); Region: DUF722; pfam05263 272622006003 Prophage protein (DUF1660); Region: DUF1660; pfam07874 272622006004 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 272622006005 trimer interface [polypeptide binding]; other site 272622006006 active site 272622006007 Protein of unknown function (DUF1642); Region: DUF1642; pfam07852 272622006008 Protein of unknown function (DUF1125); Region: DUF1125; pfam06563 272622006009 Protein of unknown function (DUF1031); Region: DUF1031; pfam06275 272622006010 Helix-turn-helix domain; Region: HTH_36; pfam13730 272622006011 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 272622006012 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 272622006013 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 272622006014 dimer interface [polypeptide binding]; other site 272622006015 ssDNA binding site [nucleotide binding]; other site 272622006016 tetramer (dimer of dimers) interface [polypeptide binding]; other site 272622006017 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4712 272622006018 Protein of unknown function (DUF1408); Region: DUF1408; pfam07193 272622006019 Hypothetical protein (DUF2513); Region: DUF2513; pfam10711 272622006020 Prophage antirepressor [Transcription]; Region: COG3617 272622006021 BRO family, N-terminal domain; Region: Bro-N; smart01040 272622006022 Phage antirepressor protein KilAC domain; Region: ANT; pfam03374 272622006023 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 272622006024 non-specific DNA binding site [nucleotide binding]; other site 272622006025 salt bridge; other site 272622006026 sequence-specific DNA binding site [nucleotide binding]; other site 272622006027 putative transcription regulator; Region: PHA00212 272622006028 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 272622006029 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272622006030 non-specific DNA binding site [nucleotide binding]; other site 272622006031 salt bridge; other site 272622006032 sequence-specific DNA binding site [nucleotide binding]; other site 272622006033 Domain of unknown function (DUF955); Region: DUF955; cl01076 272622006034 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 272622006035 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 272622006036 Int/Topo IB signature motif; other site 272622006037 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 272622006038 Small integral membrane protein (DUF2273); Region: DUF2273; cl11575 272622006039 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 272622006040 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 272622006041 putative active site [active] 272622006042 substrate binding site [chemical binding]; other site 272622006043 putative cosubstrate binding site; other site 272622006044 catalytic site [active] 272622006045 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 272622006046 substrate binding site [chemical binding]; other site 272622006047 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 272622006048 dimer interface [polypeptide binding]; other site 272622006049 Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684 272622006050 nudix motif; other site 272622006051 SnoaL-like domain; Region: SnoaL_2; pfam12680 272622006052 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 272622006053 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 272622006054 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 272622006055 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272622006056 ATP binding site [chemical binding]; other site 272622006057 putative Mg++ binding site [ion binding]; other site 272622006058 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272622006059 nucleotide binding region [chemical binding]; other site 272622006060 ATP-binding site [chemical binding]; other site 272622006061 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 272622006062 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 272622006063 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 272622006064 catalytic site [active] 272622006065 G-X2-G-X-G-K; other site 272622006066 phosphodiesterase; Provisional; Region: PRK12704 272622006067 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 272622006068 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 272622006069 Zn2+ binding site [ion binding]; other site 272622006070 Mg2+ binding site [ion binding]; other site 272622006071 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 272622006072 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 272622006073 active site 272622006074 trimer interface [polypeptide binding]; other site 272622006075 allosteric site; other site 272622006076 active site lid [active] 272622006077 S-adenosylmethionine synthetase; Validated; Region: PRK05250 272622006078 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 272622006079 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 272622006080 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 272622006081 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 272622006082 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272622006083 S-adenosylmethionine binding site [chemical binding]; other site 272622006084 Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983 272622006085 Uncharacterized conserved protein [Function unknown]; Region: COG3595 272622006086 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 272622006087 N-acetylmuramoyl-L-alanine amidase; Validated; Region: PRK08581 272622006088 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 272622006089 CHAP domain; Region: CHAP; pfam05257 272622006090 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 272622006091 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 272622006092 intersubunit interface [polypeptide binding]; other site 272622006093 active site 272622006094 zinc binding site [ion binding]; other site 272622006095 Na+ binding site [ion binding]; other site 272622006096 Predicted membrane protein [Function unknown]; Region: COG2860 272622006097 UPF0126 domain; Region: UPF0126; pfam03458 272622006098 UPF0126 domain; Region: UPF0126; pfam03458 272622006099 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 272622006100 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 272622006101 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 272622006102 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 272622006103 active site 272622006104 dimer interface [polypeptide binding]; other site 272622006105 motif 1; other site 272622006106 motif 2; other site 272622006107 motif 3; other site 272622006108 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 272622006109 anticodon binding site; other site 272622006110 ATP cone domain; Region: ATP-cone; pfam03477 272622006111 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 272622006112 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 272622006113 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 272622006114 dimer interface [polypeptide binding]; other site 272622006115 FMN binding site [chemical binding]; other site 272622006116 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 272622006117 active site 272622006118 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 272622006119 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 272622006120 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 272622006121 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 272622006122 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272622006123 homodimer interface [polypeptide binding]; other site 272622006124 catalytic residue [active] 272622006125 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674 272622006126 nudix motif; other site 272622006127 Predicted permeases [General function prediction only]; Region: COG0679 272622006128 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 272622006129 active site 272622006130 catalytic residues [active] 272622006131 Predicted HD-superfamily hydrolase [General function prediction only]; Region: COG3481 272622006132 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 272622006133 generic binding surface II; other site 272622006134 generic binding surface I; other site 272622006135 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 272622006136 Zn2+ binding site [ion binding]; other site 272622006137 Mg2+ binding site [ion binding]; other site 272622006138 Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322 272622006139 RmuC family; Region: RmuC; pfam02646 272622006140 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 272622006141 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 272622006142 substrate binding site [chemical binding]; other site 272622006143 hexamer interface [polypeptide binding]; other site 272622006144 metal binding site [ion binding]; metal-binding site 272622006145 GTPase RsgA; Reviewed; Region: PRK00098 272622006146 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 272622006147 RNA binding site [nucleotide binding]; other site 272622006148 homodimer interface [polypeptide binding]; other site 272622006149 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 272622006150 GTPase/Zn-binding domain interface [polypeptide binding]; other site 272622006151 GTP/Mg2+ binding site [chemical binding]; other site 272622006152 G4 box; other site 272622006153 G1 box; other site 272622006154 Switch I region; other site 272622006155 G2 box; other site 272622006156 G3 box; other site 272622006157 Switch II region; other site 272622006158 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 272622006159 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 272622006160 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 272622006161 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 272622006162 putative tRNA-binding site [nucleotide binding]; other site 272622006163 B3/4 domain; Region: B3_4; pfam03483 272622006164 tRNA synthetase B5 domain; Region: B5; smart00874 272622006165 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 272622006166 dimer interface [polypeptide binding]; other site 272622006167 motif 1; other site 272622006168 motif 3; other site 272622006169 motif 2; other site 272622006170 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 272622006171 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 272622006172 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 272622006173 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 272622006174 dimer interface [polypeptide binding]; other site 272622006175 motif 1; other site 272622006176 active site 272622006177 motif 2; other site 272622006178 motif 3; other site 272622006179 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 272622006180 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 272622006181 Predicted transcriptional regulators [Transcription]; Region: COG1695 272622006182 Transcriptional regulator PadR-like family; Region: PadR; cl17335 272622006183 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 272622006184 GH18 domain of Chitinase D (ChiD). ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins. The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871 272622006185 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 272622006186 putative active site [active] 272622006187 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 272622006188 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 272622006189 Interdomain contacts; other site 272622006190 Cytokine receptor motif; other site 272622006191 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 272622006192 aromatic chitin/cellulose binding site residues [chemical binding]; other site 272622006193 Chitin binding domain; Region: Chitin_bind_3; pfam03067 272622006194 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 272622006195 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 272622006196 GDP-binding site [chemical binding]; other site 272622006197 ACT binding site; other site 272622006198 IMP binding site; other site 272622006199 Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300 272622006200 Cadmium resistance transporter; Region: Cad; pfam03596 272622006201 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 272622006202 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 272622006203 dimerization interface [polypeptide binding]; other site 272622006204 domain crossover interface; other site 272622006205 redox-dependent activation switch; other site 272622006206 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 272622006207 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 272622006208 Protein of unknown function (DUF805); Region: DUF805; pfam05656 272622006209 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 272622006210 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 272622006211 FMN binding site [chemical binding]; other site 272622006212 active site 272622006213 catalytic residues [active] 272622006214 substrate binding site [chemical binding]; other site 272622006215 Uncharacterized conserved protein [Function unknown]; Region: COG1284 272622006216 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 272622006217 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 272622006218 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 272622006219 Uncharacterized conserved protein [Function unknown]; Region: COG1284 272622006220 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 272622006221 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 272622006222 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 272622006223 Uncharacterized conserved protein [Function unknown]; Region: COG1284 272622006224 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 272622006225 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 272622006226 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 272622006227 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 272622006228 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 272622006229 dimer interface [polypeptide binding]; other site 272622006230 anticodon binding site; other site 272622006231 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 272622006232 homodimer interface [polypeptide binding]; other site 272622006233 motif 1; other site 272622006234 active site 272622006235 motif 2; other site 272622006236 GAD domain; Region: GAD; pfam02938 272622006237 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 272622006238 active site 272622006239 motif 3; other site 272622006240 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 272622006241 nucleotide binding site/active site [active] 272622006242 HIT family signature motif; other site 272622006243 catalytic residue [active] 272622006244 histidyl-tRNA synthetase; Region: hisS; TIGR00442 272622006245 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 272622006246 dimer interface [polypeptide binding]; other site 272622006247 motif 1; other site 272622006248 active site 272622006249 motif 2; other site 272622006250 motif 3; other site 272622006251 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 272622006252 anticodon binding site; other site 272622006253 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272622006254 sequence-specific DNA binding site [nucleotide binding]; other site 272622006255 salt bridge; other site 272622006256 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 272622006257 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 272622006258 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 272622006259 Helix-turn-helix domain; Region: HTH_25; pfam13413 272622006260 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 272622006261 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 272622006262 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 272622006263 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 272622006264 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 272622006265 S4-like RNA binding protein [Replication, recombination, and repair]; Region: COG2501 272622006266 recF protein; Region: recf; TIGR00611 272622006267 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 272622006268 Walker A/P-loop; other site 272622006269 ATP binding site [chemical binding]; other site 272622006270 Q-loop/lid; other site 272622006271 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272622006272 ABC transporter signature motif; other site 272622006273 Walker B; other site 272622006274 D-loop; other site 272622006275 H-loop/switch region; other site 272622006276 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 272622006277 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 272622006278 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 272622006279 DNA binding residues [nucleotide binding] 272622006280 putative dimer interface [polypeptide binding]; other site 272622006281 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 272622006282 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 272622006283 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 272622006284 NAD binding site [chemical binding]; other site 272622006285 homodimer interface [polypeptide binding]; other site 272622006286 active site 272622006287 substrate binding site [chemical binding]; other site 272622006288 galactose-1-phosphate uridylyltransferase, family 2; Region: galT_2; TIGR01239 272622006289 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 272622006290 Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744 272622006291 galactokinase; Provisional; Region: PRK05322 272622006292 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 272622006293 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 272622006294 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 272622006295 active site 272622006296 catalytic residues [active] 272622006297 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 272622006298 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272622006299 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 272622006300 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 272622006301 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 272622006302 putative active site [active] 272622006303 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 272622006304 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 272622006305 active site 272622006306 catalytic tetrad [active] 272622006307 nicotinamide-nucleotide adenylyltransferase, NadR type; Region: nadR_NMN_Atrans; TIGR01526 272622006308 Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional NadR-like proteins; Region: NMNAT_NadR; cd02167 272622006309 active site 272622006310 (T/H)XGH motif; other site 272622006311 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 272622006312 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 272622006313 Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300 272622006314 NAD binding site [chemical binding]; other site 272622006315 ligand binding site [chemical binding]; other site 272622006316 catalytic site [active] 272622006317 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 272622006318 Peptidase family U32; Region: Peptidase_U32; pfam01136 272622006319 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 272622006320 Peptidase family U32; Region: Peptidase_U32; pfam01136 272622006321 Protein of unknown function (DUF3270); Region: DUF3270; pfam11674 272622006322 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 272622006323 Methyltransferase domain; Region: Methyltransf_11; pfam08241 272622006324 Protein of unknown function (DUF722); Region: DUF722; pfam05263 272622006325 Phage terminase, small subunit [DNA replication, recombination, and repair]; Region: XtmA; COG3728 272622006326 Phage associated DNA primase [General function prediction only]; Region: COG3378 272622006327 D5 N terminal like; Region: D5_N; smart00885 272622006328 Poxvirus D5 protein-like; Region: Pox_D5; pfam03288 272622006329 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 272622006330 polymerase nucleotide-binding site; other site 272622006331 DNA-binding residues [nucleotide binding]; DNA binding site 272622006332 nucleotide binding site [chemical binding]; other site 272622006333 primase nucleotide-binding site [nucleotide binding]; other site 272622006334 Primase C terminal 1 (PriCT-1); Region: PriCT_1; smart00942 272622006335 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272622006336 non-specific DNA binding site [nucleotide binding]; other site 272622006337 salt bridge; other site 272622006338 sequence-specific DNA binding site [nucleotide binding]; other site 272622006339 Protein of unknown function (DUF1655); Region: DUF1655; pfam07868 272622006340 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 272622006341 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 272622006342 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272622006343 non-specific DNA binding site [nucleotide binding]; other site 272622006344 salt bridge; other site 272622006345 sequence-specific DNA binding site [nucleotide binding]; other site 272622006346 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 272622006347 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; cl17626 272622006348 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 272622006349 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 272622006350 Int/Topo IB signature motif; other site 272622006351 CutC family; Region: CutC; pfam03932 272622006352 Predicted ABC-type exoprotein transport system, permease component [Intracellular trafficking and secretion]; Region: EcsB; COG4473 272622006353 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 272622006354 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 272622006355 Walker A/P-loop; other site 272622006356 ATP binding site [chemical binding]; other site 272622006357 Q-loop/lid; other site 272622006358 ABC transporter signature motif; other site 272622006359 Walker B; other site 272622006360 D-loop; other site 272622006361 H-loop/switch region; other site 272622006362 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; cl01974 272622006363 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 272622006364 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 272622006365 putative active site [active] 272622006366 catalytic site [active] 272622006367 putative metal binding site [ion binding]; other site 272622006368 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 272622006369 HIT family signature motif; other site 272622006370 catalytic residue [active] 272622006371 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 272622006372 mRNA/rRNA interface [nucleotide binding]; other site 272622006373 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 272622006374 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 272622006375 23S rRNA interface [nucleotide binding]; other site 272622006376 L7/L12 interface [polypeptide binding]; other site 272622006377 putative thiostrepton binding site; other site 272622006378 L25 interface [polypeptide binding]; other site 272622006379 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 272622006380 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 272622006381 Walker A/P-loop; other site 272622006382 ATP binding site [chemical binding]; other site 272622006383 Q-loop/lid; other site 272622006384 ABC transporter signature motif; other site 272622006385 Walker B; other site 272622006386 D-loop; other site 272622006387 H-loop/switch region; other site 272622006388 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4479 272622006389 methionine sulfoxide reductase A; Provisional; Region: PRK14054 272622006390 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 272622006391 S1 domain; Region: S1_2; pfam13509 272622006392 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 272622006393 RNA binding site [nucleotide binding]; other site 272622006394 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 272622006395 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272622006396 Coenzyme A binding pocket [chemical binding]; other site 272622006397 ribosome recycling factor; Reviewed; Region: frr; PRK00083 272622006398 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 272622006399 hinge region; other site 272622006400 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 272622006401 putative nucleotide binding site [chemical binding]; other site 272622006402 uridine monophosphate binding site [chemical binding]; other site 272622006403 homohexameric interface [polypeptide binding]; other site 272622006404 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 272622006405 propionate/acetate kinase; Provisional; Region: PRK12379 272622006406 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 272622006407 propionate/acetate kinase; Provisional; Region: PRK12379 272622006408 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 272622006409 Methyltransferase domain; Region: Methyltransf_26; pfam13659 272622006410 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 272622006411 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 272622006412 G1 box; other site 272622006413 putative GEF interaction site [polypeptide binding]; other site 272622006414 GTP/Mg2+ binding site [chemical binding]; other site 272622006415 Switch I region; other site 272622006416 G2 box; other site 272622006417 G3 box; other site 272622006418 Switch II region; other site 272622006419 G4 box; other site 272622006420 G5 box; other site 272622006421 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 272622006422 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 272622006423 putative transposase OrfB; Reviewed; Region: PHA02517 272622006424 HTH-like domain; Region: HTH_21; pfam13276 272622006425 Integrase core domain; Region: rve; pfam00665 272622006426 Integrase core domain; Region: rve_3; pfam13683 272622006427 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 272622006428 Transposase; Region: HTH_Tnp_1; pfam01527 272622006429 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 272622006430 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 272622006431 LytTr DNA-binding domain; Region: LytTR; cl04498 272622006432 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4483 272622006433 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 272622006434 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 272622006435 nucleotide binding site [chemical binding]; other site 272622006436 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 272622006437 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 272622006438 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 272622006439 dimerization interface [polypeptide binding]; other site 272622006440 DPS ferroxidase diiron center [ion binding]; other site 272622006441 ion pore; other site 272622006442 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 272622006443 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 272622006444 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 272622006445 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 272622006446 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 272622006447 active site 272622006448 DNA polymerase IV; Validated; Region: PRK02406 272622006449 DNA binding site [nucleotide binding] 272622006450 This CD includes bacterial (Agrobacterium tumefaciens and Caulobacter crescentus ProX, and Clostridium sticklandii PrdX) and eukaryotic (Plasmodium falciparum N-terminal ProRS editing domain) sequences. The C. sticklandii PrdX protein, a homolog of the...; Region: PrdX_deacylase; cd04335 272622006451 putative deacylase active site [active] 272622006452 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 272622006453 transaminase; Validated; Region: PRK07324 272622006454 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 272622006455 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272622006456 homodimer interface [polypeptide binding]; other site 272622006457 catalytic residue [active] 272622006458 carbamate kinase; Reviewed; Region: PRK12686 272622006459 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 272622006460 putative substrate binding site [chemical binding]; other site 272622006461 nucleotide binding site [chemical binding]; other site 272622006462 nucleotide binding site [chemical binding]; other site 272622006463 homodimer interface [polypeptide binding]; other site 272622006464 carbamate kinase; Reviewed; Region: PRK12686 272622006465 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 272622006466 putative substrate binding site [chemical binding]; other site 272622006467 nucleotide binding site [chemical binding]; other site 272622006468 nucleotide binding site [chemical binding]; other site 272622006469 homodimer interface [polypeptide binding]; other site 272622006470 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 272622006471 ornithine carbamoyltransferase; Validated; Region: PRK02102 272622006472 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 272622006473 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 272622006474 arginyl-tRNA synthetase; Reviewed; Region: PRK12451 272622006475 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 272622006476 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 272622006477 active site 272622006478 HIGH motif; other site 272622006479 KMSK motif region; other site 272622006480 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 272622006481 tRNA binding surface [nucleotide binding]; other site 272622006482 anticodon binding site; other site 272622006483 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 272622006484 arginine repressor; Region: argR_whole; TIGR01529 272622006485 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 272622006486 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 272622006487 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 272622006488 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 272622006489 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 272622006490 SWIM zinc finger; Region: SWIM; pfam04434 272622006491 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 272622006492 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 272622006493 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272622006494 ATP binding site [chemical binding]; other site 272622006495 putative Mg++ binding site [ion binding]; other site 272622006496 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272622006497 nucleotide binding region [chemical binding]; other site 272622006498 ATP-binding site [chemical binding]; other site 272622006499 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 272622006500 Transposase; Region: HTH_Tnp_1; pfam01527 272622006501 putative transposase OrfB; Reviewed; Region: PHA02517 272622006502 HTH-like domain; Region: HTH_21; pfam13276 272622006503 Integrase core domain; Region: rve; pfam00665 272622006504 Integrase core domain; Region: rve_3; pfam13683 272622006505 Beta-lactamase; Region: Beta-lactamase; pfam00144 272622006506 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 272622006507 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 272622006508 Transposase, Mutator family; Region: Transposase_mut; pfam00872 272622006509 MULE transposase domain; Region: MULE; pfam10551 272622006510 Domain of unknown function (DU1801); Region: DUF1801; cl17490 272622006511 Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467 272622006512 CAAX protease self-immunity; Region: Abi; pfam02517 272622006513 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 272622006514 amphipathic channel; other site 272622006515 Asn-Pro-Ala signature motifs; other site 272622006516 x-prolyl-dipeptidyl aminopeptidase; Provisional; Region: PRK05371 272622006517 X-Prolyl dipeptidyl aminopeptidase PepX, N-terminal; Region: PepX_N; smart00940 272622006518 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 272622006519 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 272622006520 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 272622006521 substrate binding pocket [chemical binding]; other site 272622006522 membrane-bound complex binding site; other site 272622006523 hinge residues; other site 272622006524 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 272622006525 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 272622006526 active site 272622006527 HIGH motif; other site 272622006528 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 272622006529 active site 272622006530 KMSKS motif; other site 272622006531 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 272622006532 Isochorismatase family; Region: Isochorismatase; pfam00857 272622006533 catalytic triad [active] 272622006534 conserved cis-peptide bond; other site 272622006535 Isochorismatase family; Region: Isochorismatase; pfam00857 272622006536 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 272622006537 catalytic triad [active] 272622006538 conserved cis-peptide bond; other site 272622006539 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272622006540 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272622006541 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 272622006542 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 272622006543 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 272622006544 DNA-binding ferritin-like protein (Dps family) [General function prediction only]; Region: COG4817 272622006545 Protein of unknown function (DUF1048); Region: DUF1048; pfam06304 272622006546 Predicted transcriptional regulators [Transcription]; Region: COG1695 272622006547 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 272622006548 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 272622006549 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 272622006550 putative active site [active] 272622006551 Predicted membrane protein [Function unknown]; Region: COG3619 272622006552 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 272622006553 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 272622006554 DNA repair protein RadA; Provisional; Region: PRK11823 272622006555 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 272622006556 Walker A motif/ATP binding site; other site 272622006557 ATP binding site [chemical binding]; other site 272622006558 Walker B motif; other site 272622006559 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 272622006560 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 272622006561 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 272622006562 active site 272622006563 histidinol-phosphate phosphatase family domain; Region: Histidinol-ppas; TIGR01656 272622006564 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272622006565 active site 272622006566 motif I; other site 272622006567 motif II; other site 272622006568 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 272622006569 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 272622006570 dimer interface [polypeptide binding]; other site 272622006571 active site 272622006572 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 272622006573 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 272622006574 GDP-fucose protein O-fucosyltransferase and related proteins; Region: O-FucT_like; cl16914 272622006575 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 272622006576 active site 272622006577 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 272622006578 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 272622006579 active site 272622006580 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 272622006581 FemAB family; Region: FemAB; pfam02388 272622006582 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 272622006583 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 272622006584 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 272622006585 alphaNTD homodimer interface [polypeptide binding]; other site 272622006586 alphaNTD - beta interaction site [polypeptide binding]; other site 272622006587 alphaNTD - beta' interaction site [polypeptide binding]; other site 272622006588 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 272622006589 30S ribosomal protein S11; Validated; Region: PRK05309 272622006590 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 272622006591 30S ribosomal protein S13; Region: bact_S13; TIGR03631 272622006592 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 272622006593 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 272622006594 rRNA binding site [nucleotide binding]; other site 272622006595 predicted 30S ribosome binding site; other site 272622006596 adenylate kinase; Reviewed; Region: adk; PRK00279 272622006597 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 272622006598 AMP-binding site [chemical binding]; other site 272622006599 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 272622006600 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 272622006601 SecY translocase; Region: SecY; pfam00344 272622006602 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 272622006603 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 272622006604 23S rRNA binding site [nucleotide binding]; other site 272622006605 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 272622006606 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 272622006607 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 272622006608 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 272622006609 5S rRNA interface [nucleotide binding]; other site 272622006610 L27 interface [polypeptide binding]; other site 272622006611 23S rRNA interface [nucleotide binding]; other site 272622006612 L5 interface [polypeptide binding]; other site 272622006613 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 272622006614 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 272622006615 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 272622006616 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 272622006617 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 272622006618 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 272622006619 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 272622006620 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 272622006621 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 272622006622 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 272622006623 RNA binding site [nucleotide binding]; other site 272622006624 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 272622006625 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 272622006626 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 272622006627 23S rRNA interface [nucleotide binding]; other site 272622006628 putative translocon interaction site; other site 272622006629 signal recognition particle (SRP54) interaction site; other site 272622006630 L23 interface [polypeptide binding]; other site 272622006631 trigger factor interaction site; other site 272622006632 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 272622006633 23S rRNA interface [nucleotide binding]; other site 272622006634 5S rRNA interface [nucleotide binding]; other site 272622006635 putative antibiotic binding site [chemical binding]; other site 272622006636 L25 interface [polypeptide binding]; other site 272622006637 L27 interface [polypeptide binding]; other site 272622006638 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 272622006639 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 272622006640 G-X-X-G motif; other site 272622006641 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 272622006642 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 272622006643 putative translocon binding site; other site 272622006644 protein-rRNA interface [nucleotide binding]; other site 272622006645 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 272622006646 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 272622006647 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 272622006648 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 272622006649 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 272622006650 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 272622006651 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 272622006652 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 272622006653 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 272622006654 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 272622006655 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 272622006656 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 272622006657 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 272622006658 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272622006659 catalytic residue [active] 272622006660 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 272622006661 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 272622006662 putative homodimer interface [polypeptide binding]; other site 272622006663 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 272622006664 heterodimer interface [polypeptide binding]; other site 272622006665 homodimer interface [polypeptide binding]; other site 272622006666 Preprotein translocase subunit SecE [Intracellular trafficking and secretion]; Region: SecE; COG0690 272622006667 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 272622006668 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 272622006669 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 272622006670 catalytic triad [active] 272622006671 catalytic triad [active] 272622006672 oxyanion hole [active] 272622006673 Transglycosylase; Region: Transgly; pfam00912 272622006674 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 272622006675 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 272622006676 Predicted membrane protein [Function unknown]; Region: COG2323 272622006677 Protein of unknown function (DUF3290); Region: DUF3290; pfam11694 272622006678 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 272622006679 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 272622006680 active site 272622006681 putative transposase OrfB; Reviewed; Region: PHA02517 272622006682 HTH-like domain; Region: HTH_21; pfam13276 272622006683 Integrase core domain; Region: rve; pfam00665 272622006684 Integrase core domain; Region: rve_2; pfam13333 272622006685 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 272622006686 Helix-turn-helix domain; Region: HTH_28; pfam13518 272622006687 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 272622006688 Transposase; Region: HTH_Tnp_1; cl17663 272622006689 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 272622006690 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 272622006691 ABC-ATPase subunit interface; other site 272622006692 dimer interface [polypeptide binding]; other site 272622006693 putative PBP binding regions; other site 272622006694 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 272622006695 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 272622006696 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 272622006697 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 272622006698 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 272622006699 metal binding site [ion binding]; metal-binding site 272622006700 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 272622006701 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 272622006702 putative DNA binding site [nucleotide binding]; other site 272622006703 putative Zn2+ binding site [ion binding]; other site 272622006704 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 272622006705 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 272622006706 Type II secretory pathway pseudopilin; Region: PulG; pfam11773 272622006707 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 272622006708 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 272622006709 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 272622006710 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 272622006711 DNA polymerase III, alpha subunit (gram-positive type) [DNA replication, recombination, and repair]; Region: PolC; COG2176 272622006712 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 272622006713 generic binding surface II; other site 272622006714 generic binding surface I; other site 272622006715 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 272622006716 generic binding surface II; other site 272622006717 generic binding surface I; other site 272622006718 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 272622006719 active site 272622006720 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 272622006721 active site 272622006722 catalytic site [active] 272622006723 substrate binding site [chemical binding]; other site 272622006724 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 272622006725 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 272622006726 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 272622006727 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 272622006728 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 272622006729 prolyl-tRNA synthetase; Provisional; Region: PRK09194 272622006730 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 272622006731 dimer interface [polypeptide binding]; other site 272622006732 motif 1; other site 272622006733 active site 272622006734 motif 2; other site 272622006735 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 272622006736 putative deacylase active site [active] 272622006737 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 272622006738 active site 272622006739 motif 3; other site 272622006740 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 272622006741 anticodon binding site; other site 272622006742 RIP metalloprotease RseP; Region: TIGR00054 272622006743 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 272622006744 active site 272622006745 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cd05709 272622006746 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 272622006747 protein binding site [polypeptide binding]; other site 272622006748 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 272622006749 putative substrate binding region [chemical binding]; other site 272622006750 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 272622006751 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 272622006752 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14830 272622006753 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 272622006754 catalytic residue [active] 272622006755 putative FPP diphosphate binding site; other site 272622006756 putative FPP binding hydrophobic cleft; other site 272622006757 dimer interface [polypeptide binding]; other site 272622006758 putative IPP diphosphate binding site; other site 272622006759 Preprotein translocase subunit; Region: YajC; cl00806 272622006760 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 272622006761 A new structural DNA glycosylase containing HEAT-like repeats; Region: AlkD_like_1; cd07064 272622006762 active site 272622006763 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 272622006764 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 272622006765 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 272622006766 protein binding site [polypeptide binding]; other site 272622006767 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 272622006768 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 272622006769 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 272622006770 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 272622006771 putative ADP-binding pocket [chemical binding]; other site 272622006772 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4703 272622006773 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 272622006774 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272622006775 S-adenosylmethionine binding site [chemical binding]; other site 272622006776 DNA polymerase I; Provisional; Region: PRK05755 272622006777 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 272622006778 active site 272622006779 metal binding site 1 [ion binding]; metal-binding site 272622006780 putative 5' ssDNA interaction site; other site 272622006781 metal binding site 3; metal-binding site 272622006782 metal binding site 2 [ion binding]; metal-binding site 272622006783 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 272622006784 putative DNA binding site [nucleotide binding]; other site 272622006785 putative metal binding site [ion binding]; other site 272622006786 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 272622006787 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 272622006788 active site 272622006789 DNA binding site [nucleotide binding] 272622006790 catalytic site [active] 272622006791 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 272622006792 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 272622006793 active site 272622006794 motif I; other site 272622006795 motif II; other site 272622006796 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 272622006797 Transcriptional regulators [Transcription]; Region: PurR; COG1609 272622006798 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 272622006799 DNA binding site [nucleotide binding] 272622006800 domain linker motif; other site 272622006801 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 272622006802 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 272622006803 Negative regulator of septation ring formation [Cell division and chromosome partitioning]; Region: EzrA; COG4477 272622006804 elongation factor Ts; Provisional; Region: tsf; PRK09377 272622006805 UBA/TS-N domain; Region: UBA; pfam00627 272622006806 Elongation factor TS; Region: EF_TS; pfam00889 272622006807 Elongation factor TS; Region: EF_TS; pfam00889 272622006808 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 272622006809 rRNA interaction site [nucleotide binding]; other site 272622006810 S8 interaction site; other site 272622006811 putative laminin-1 binding site; other site 272622006812 3-carboxymuconate cyclase [Carbohydrate transport and metabolism]; Region: COG2706 272622006813 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 272622006814 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 272622006815 putative catalytic cysteine [active] 272622006816 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 272622006817 putative active site [active] 272622006818 metal binding site [ion binding]; metal-binding site 272622006819 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 272622006820 dimer interface [polypeptide binding]; other site 272622006821 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 272622006822 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 272622006823 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 272622006824 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 272622006825 protein binding site [polypeptide binding]; other site 272622006826 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 272622006827 Phosphopantetheine adenylyltransferase [Coenzyme metabolism]; Region: CoaD; COG0669 272622006828 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 272622006829 active site 272622006830 (T/H)XGH motif; other site 272622006831 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 272622006832 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272622006833 S-adenosylmethionine binding site [chemical binding]; other site 272622006834 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272622006835 Major Facilitator Superfamily; Region: MFS_1; pfam07690 272622006836 putative substrate translocation pore; other site 272622006837 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 272622006838 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 272622006839 DNA binding residues [nucleotide binding] 272622006840 Sigma factor regulator N-terminal; Region: Sigma_reg_N; pfam13800 272622006841 Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791 272622006842 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 272622006843 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 272622006844 active site 272622006845 dimer interface [polypeptide binding]; other site 272622006846 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 272622006847 dimer interface [polypeptide binding]; other site 272622006848 active site 272622006849 Flagellin N-methylase; Region: FliB; pfam03692 272622006850 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 272622006851 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272622006852 NAD(P) binding site [chemical binding]; other site 272622006853 active site 272622006854 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272622006855 non-specific DNA binding site [nucleotide binding]; other site 272622006856 salt bridge; other site 272622006857 sequence-specific DNA binding site [nucleotide binding]; other site 272622006858 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272622006859 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 272622006860 NAD(P) binding site [chemical binding]; other site 272622006861 active site 272622006862 Predicted transcriptional regulators [Transcription]; Region: COG1733 272622006863 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 272622006864 putative Zn2+ binding site [ion binding]; other site 272622006865 putative DNA binding site [nucleotide binding]; other site 272622006866 Transposase, Mutator family; Region: Transposase_mut; pfam00872 272622006867 MULE transposase domain; Region: MULE; pfam10551 272622006868 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 272622006869 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 272622006870 active site 272622006871 HIGH motif; other site 272622006872 nucleotide binding site [chemical binding]; other site 272622006873 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 272622006874 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 272622006875 active site 272622006876 KMSKS motif; other site 272622006877 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 272622006878 tRNA binding surface [nucleotide binding]; other site 272622006879 anticodon binding site; other site 272622006880 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 272622006881 Domain of unknown function (DUF1912); Region: DUF1912; pfam08930 272622006882 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 272622006883 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 272622006884 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 272622006885 Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382 272622006886 B3/4 domain; Region: B3_4; pfam03483 272622006887 TRAM domain; Region: TRAM; pfam01938 272622006888 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 272622006889 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272622006890 S-adenosylmethionine binding site [chemical binding]; other site 272622006891 legume lectins; Region: lectin_L-type; cl14058 272622006892 carbohydrate binding site [chemical binding]; other site 272622006893 metal binding site [ion binding]; metal-binding site 272622006894 recombination regulator RecX; Provisional; Region: recX; PRK14135 272622006895 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 272622006896 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 272622006897 N- and C-terminal domain interface [polypeptide binding]; other site 272622006898 active site 272622006899 catalytic site [active] 272622006900 metal binding site [ion binding]; metal-binding site 272622006901 carbohydrate binding site [chemical binding]; other site 272622006902 ATP binding site [chemical binding]; other site 272622006903 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 272622006904 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 272622006905 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 272622006906 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 272622006907 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 272622006908 putative active site [active] 272622006909 Staphylococcal protein of unknown function (DUF960); Region: DUF960; pfam06124 272622006910 phosphodiesterase YaeI; Provisional; Region: PRK11340 272622006911 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 272622006912 putative active site [active] 272622006913 putative metal binding site [ion binding]; other site 272622006914 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 272622006915 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 272622006916 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 272622006917 dimer interface [polypeptide binding]; other site 272622006918 ssDNA binding site [nucleotide binding]; other site 272622006919 tetramer (dimer of dimers) interface [polypeptide binding]; other site 272622006920 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 272622006921 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 272622006922 Amino acid transporters [Amino acid transport and metabolism]; Region: LysP; COG0833 272622006923 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 272622006924 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272622006925 Walker A motif; other site 272622006926 ATP binding site [chemical binding]; other site 272622006927 Walker B motif; other site 272622006928 arginine finger; other site 272622006929 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 272622006930 Phosphotransferase enzyme family; Region: APH; pfam01636 272622006931 substrate binding site [chemical binding]; other site 272622006932 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 272622006933 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 272622006934 hypothetical protein; Provisional; Region: PRK07248 272622006935 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 272622006936 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 272622006937 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 272622006938 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 272622006939 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 272622006940 DNA binding residues [nucleotide binding] 272622006941 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 272622006942 Low molecular weight phosphatase family; Region: LMWPc; cd00115 272622006943 active site 272622006944 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 272622006945 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272622006946 Walker A motif; other site 272622006947 ATP binding site [chemical binding]; other site 272622006948 Walker B motif; other site 272622006949 arginine finger; other site 272622006950 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 272622006951 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 272622006952 RuvA N terminal domain; Region: RuvA_N; pfam01330 272622006953 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 272622006954 helix-hairpin-helix signature motif; other site 272622006955 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 272622006956 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272622006957 ATP binding site [chemical binding]; other site 272622006958 Mg2+ binding site [ion binding]; other site 272622006959 G-X-G motif; other site 272622006960 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 272622006961 ATP binding site [chemical binding]; other site 272622006962 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 272622006963 Protein of unknown function (DUF805); Region: DUF805; pfam05656 272622006964 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 272622006965 MutS domain I; Region: MutS_I; pfam01624 272622006966 MutS domain II; Region: MutS_II; pfam05188 272622006967 MutS domain III; Region: MutS_III; pfam05192 272622006968 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 272622006969 Walker A/P-loop; other site 272622006970 ATP binding site [chemical binding]; other site 272622006971 Q-loop/lid; other site 272622006972 ABC transporter signature motif; other site 272622006973 Walker B; other site 272622006974 D-loop; other site 272622006975 H-loop/switch region; other site 272622006976 Predicted membrane protein [Function unknown]; Region: COG4550 272622006977 Protein of unknown function (DUF1634); Region: DUF1634; cl01741 272622006978 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 272622006979 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 272622006980 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 272622006981 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 272622006982 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 272622006983 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272622006984 active site 272622006985 motif I; other site 272622006986 motif II; other site 272622006987 chaperone protein DnaJ; Provisional; Region: PRK14276 272622006988 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 272622006989 HSP70 interaction site [polypeptide binding]; other site 272622006990 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 272622006991 substrate binding site [polypeptide binding]; other site 272622006992 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 272622006993 Zn binding sites [ion binding]; other site 272622006994 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 272622006995 substrate binding site [polypeptide binding]; other site 272622006996 dimer interface [polypeptide binding]; other site 272622006997 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4990 272622006998 aspartate racemase; Region: asp_race; TIGR00035 272622006999 Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794 272622007000 Predicted ATP-grasp enzyme [General function prediction only]; Region: COG3919 272622007001 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 272622007002 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 272622007003 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 272622007004 active site 272622007005 dimer interface [polypeptide binding]; other site 272622007006 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 272622007007 Ligand Binding Site [chemical binding]; other site 272622007008 Molecular Tunnel; other site 272622007009 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 272622007010 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 272622007011 Surface antigen [General function prediction only]; Region: COG3942 272622007012 CHAP domain; Region: CHAP; pfam05257 272622007013 rod shape-determining protein MreD; Region: MreD; pfam04093 272622007014 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreC; COG1792 272622007015 rod shape-determining protein MreC; Region: MreC; pfam04085 272622007016 Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684 272622007017 nudix motif; other site 272622007018 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 272622007019 tetramer (dimer of dimers) interface [polypeptide binding]; other site 272622007020 active site 272622007021 dimer interface [polypeptide binding]; other site 272622007022 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 272622007023 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 272622007024 ligand binding site [chemical binding]; other site 272622007025 flexible hinge region; other site 272622007026 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 272622007027 putative switch regulator; other site 272622007028 non-specific DNA interactions [nucleotide binding]; other site 272622007029 DNA binding site [nucleotide binding] 272622007030 sequence specific DNA binding site [nucleotide binding]; other site 272622007031 putative cAMP binding site [chemical binding]; other site 272622007032 Major Facilitator Superfamily; Region: MFS_1; pfam07690 272622007033 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272622007034 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 272622007035 Ligand Binding Site [chemical binding]; other site 272622007036 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 272622007037 nucleotide binding site [chemical binding]; other site 272622007038 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 272622007039 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 272622007040 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3580 272622007041 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 272622007042 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 272622007043 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 272622007044 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 272622007045 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 272622007046 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 272622007047 RNA binding surface [nucleotide binding]; other site 272622007048 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 272622007049 active site 272622007050 uracil binding [chemical binding]; other site 272622007051 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 272622007052 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 272622007053 trmE is a tRNA modification GTPase; Region: trmE; cd04164 272622007054 G1 box; other site 272622007055 GTP/Mg2+ binding site [chemical binding]; other site 272622007056 Switch I region; other site 272622007057 G2 box; other site 272622007058 Switch II region; other site 272622007059 G3 box; other site 272622007060 G4 box; other site 272622007061 G5 box; other site 272622007062 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 272622007063 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 272622007064 active site 272622007065 ATP binding site [chemical binding]; other site 272622007066 substrate binding site [chemical binding]; other site 272622007067 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 272622007068 activation loop (A-loop); other site 272622007069 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 272622007070 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272622007071 non-specific DNA binding site [nucleotide binding]; other site 272622007072 salt bridge; other site 272622007073 sequence-specific DNA binding site [nucleotide binding]; other site 272622007074 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 272622007075 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 272622007076 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 272622007077 generic binding surface II; other site 272622007078 ssDNA binding site; other site 272622007079 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272622007080 ATP binding site [chemical binding]; other site 272622007081 putative Mg++ binding site [ion binding]; other site 272622007082 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272622007083 nucleotide binding region [chemical binding]; other site 272622007084 ATP-binding site [chemical binding]; other site 272622007085 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 272622007086 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 272622007087 PhnA protein; Region: PhnA; pfam03831 272622007088 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 272622007089 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 272622007090 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 272622007091 seryl-tRNA synthetase; Region: serS; TIGR00414 272622007092 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 272622007093 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 272622007094 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 272622007095 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 272622007096 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 272622007097 motif II; other site 272622007098 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 272622007099 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 272622007100 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 272622007101 oxidoreductase; Provisional; Region: PRK06196 272622007102 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272622007103 NAD(P) binding site [chemical binding]; other site 272622007104 active site 272622007105 CAAX protease self-immunity; Region: Abi; pfam02517 272622007106 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272622007107 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3421 272622007108 ATP binding site [chemical binding]; other site 272622007109 putative Mg++ binding site [ion binding]; other site 272622007110 Type III restriction/modification enzyme methylation subunit; Region: TypeIII_RM_meth; pfam12564 272622007111 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 272622007112 DNA methylase; Region: N6_N4_Mtase; pfam01555 272622007113 DNA methylase; Region: N6_N4_Mtase; pfam01555 272622007114 Divergent AAA domain; Region: AAA_4; pfam04326 272622007115 Plasmid replication protein; Region: Rep_2; pfam01719 272622007116 RNA helicase; Region: RNA_helicase; pfam00910 272622007117 Helix-turn-helix domain; Region: HTH_17; cl17695 272622007118 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 272622007119 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 272622007120 active site 272622007121 DNA binding site [nucleotide binding] 272622007122 Int/Topo IB signature motif; other site 272622007123 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 272622007124 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 272622007125 23S rRNA interface [nucleotide binding]; other site 272622007126 L3 interface [polypeptide binding]; other site 272622007127 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 272622007128 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 272622007129 FtsX-like permease family; Region: FtsX; pfam02687 272622007130 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 272622007131 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 272622007132 Walker A/P-loop; other site 272622007133 ATP binding site [chemical binding]; other site 272622007134 Q-loop/lid; other site 272622007135 ABC transporter signature motif; other site 272622007136 Walker B; other site 272622007137 D-loop; other site 272622007138 H-loop/switch region; other site 272622007139 ribonuclease HIII; Provisional; Region: PRK00996 272622007140 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 272622007141 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 272622007142 RNA/DNA hybrid binding site [nucleotide binding]; other site 272622007143 active site 272622007144 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 272622007145 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 272622007146 Catalytic site [active] 272622007147 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 272622007148 pur operon repressor; Provisional; Region: PRK09213 272622007149 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 272622007150 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 272622007151 active site 272622007152 30S ribosomal protein S7; Validated; Region: PRK05302 272622007153 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 272622007154 S17 interaction site [polypeptide binding]; other site 272622007155 S8 interaction site; other site 272622007156 16S rRNA interaction site [nucleotide binding]; other site 272622007157 streptomycin interaction site [chemical binding]; other site 272622007158 23S rRNA interaction site [nucleotide binding]; other site 272622007159 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 272622007160 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 272622007161 Beta-lactamase; Region: Beta-lactamase; cl17358 272622007162 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 272622007163 Sugar transport protein; Region: Sugar_transport; pfam06800 272622007164 Putative rRNA methylase; Region: rRNA_methylase; pfam06962 272622007165 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242