-- dump date 20140619_125259 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1295826000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 1295826000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1295826000003 Walker A motif; other site 1295826000004 ATP binding site [chemical binding]; other site 1295826000005 Walker B motif; other site 1295826000006 arginine finger; other site 1295826000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1295826000008 DnaA box-binding interface [nucleotide binding]; other site 1295826000009 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1295826000010 DNA polymerase III beta subunit; Region: POL3Bc; smart00480 1295826000011 putative DNA binding surface [nucleotide binding]; other site 1295826000012 dimer interface [polypeptide binding]; other site 1295826000013 beta-clamp/clamp loader binding surface; other site 1295826000014 beta-clamp/translesion DNA polymerase binding surface; other site 1295826000015 ATP-dependent nuclease, subunit B [DNA replication, recombination, and repair]; Region: AddB; COG3857 1295826000016 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1295826000017 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 1295826000018 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1295826000019 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1295826000020 non-specific DNA binding site [nucleotide binding]; other site 1295826000021 salt bridge; other site 1295826000022 sequence-specific DNA binding site [nucleotide binding]; other site 1295826000023 GTP-binding protein YchF; Reviewed; Region: PRK09601 1295826000024 YchF GTPase; Region: YchF; cd01900 1295826000025 G1 box; other site 1295826000026 GTP/Mg2+ binding site [chemical binding]; other site 1295826000027 Switch I region; other site 1295826000028 G2 box; other site 1295826000029 Switch II region; other site 1295826000030 G3 box; other site 1295826000031 G4 box; other site 1295826000032 G5 box; other site 1295826000033 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1295826000034 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1295826000035 non-specific DNA binding site [nucleotide binding]; other site 1295826000036 salt bridge; other site 1295826000037 sequence-specific DNA binding site [nucleotide binding]; other site 1295826000038 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1295826000039 putative active site [active] 1295826000040 catalytic residue [active] 1295826000041 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 1295826000042 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 1295826000043 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1295826000044 ATP binding site [chemical binding]; other site 1295826000045 putative Mg++ binding site [ion binding]; other site 1295826000046 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1295826000047 nucleotide binding region [chemical binding]; other site 1295826000048 ATP-binding site [chemical binding]; other site 1295826000049 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 1295826000050 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1295826000051 RNA binding surface [nucleotide binding]; other site 1295826000052 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 1295826000053 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1295826000054 RNA binding site [nucleotide binding]; other site 1295826000055 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 1295826000056 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1295826000057 Ligand Binding Site [chemical binding]; other site 1295826000058 TilS substrate C-terminal domain; Region: TilS_C; smart00977 1295826000059 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1295826000060 active site 1295826000061 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 1295826000062 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 1295826000063 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 1295826000064 active site 1295826000065 P-loop; other site 1295826000066 phosphorylation site [posttranslational modification] 1295826000067 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 1295826000068 active site 1295826000069 P-loop; other site 1295826000070 phosphorylation site [posttranslational modification] 1295826000071 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1295826000072 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 1295826000073 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 1295826000074 active site 1295826000075 P-loop; other site 1295826000076 phosphorylation site [posttranslational modification] 1295826000077 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1295826000078 active site 1295826000079 phosphorylation site [posttranslational modification] 1295826000080 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 1295826000081 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1295826000082 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1295826000083 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 1295826000084 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1295826000085 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1295826000086 Coenzyme A binding pocket [chemical binding]; other site 1295826000087 Predicted membrane protein [Function unknown]; Region: XynA; COG2314 1295826000088 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1295826000089 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1295826000090 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1295826000091 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1295826000092 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1295826000093 Coenzyme A binding pocket [chemical binding]; other site 1295826000094 aromatic amino acid aminotransferase; Validated; Region: PRK07309 1295826000095 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1295826000096 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1295826000097 homodimer interface [polypeptide binding]; other site 1295826000098 catalytic residue [active] 1295826000099 Recombination protein O N terminal; Region: RecO_N; pfam11967 1295826000100 Recombinational DNA repair protein (RecF pathway) [DNA replication, recombination, and repair]; Region: RecO; COG1381 1295826000101 Recombination protein O C terminal; Region: RecO_C; pfam02565 1295826000102 MFS/sugar transport protein; Region: MFS_2; pfam13347 1295826000103 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 1295826000104 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1295826000105 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1295826000106 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1295826000107 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1295826000108 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 1295826000109 E3 interaction surface; other site 1295826000110 lipoyl attachment site [posttranslational modification]; other site 1295826000111 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1295826000112 E3 interaction surface; other site 1295826000113 lipoyl attachment site [posttranslational modification]; other site 1295826000114 e3 binding domain; Region: E3_binding; pfam02817 1295826000115 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1295826000116 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1295826000117 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1295826000118 TPP binding site [chemical binding]; other site 1295826000119 alpha subunit interface [polypeptide binding]; other site 1295826000120 heterodimer interface [polypeptide binding]; other site 1295826000121 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1295826000122 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 1295826000123 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1295826000124 tetramer interface [polypeptide binding]; other site 1295826000125 TPP-binding site [chemical binding]; other site 1295826000126 heterodimer interface [polypeptide binding]; other site 1295826000127 phosphorylation loop region [posttranslational modification] 1295826000128 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 1295826000129 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1295826000130 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 1295826000131 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1295826000132 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 1295826000133 active site 1295826000134 catalytic site [active] 1295826000135 metal binding site [ion binding]; metal-binding site 1295826000136 dimer interface [polypeptide binding]; other site 1295826000137 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 1295826000138 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1295826000139 Zn2+ binding site [ion binding]; other site 1295826000140 Mg2+ binding site [ion binding]; other site 1295826000141 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1295826000142 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1295826000143 active site 1295826000144 HIGH motif; other site 1295826000145 dimer interface [polypeptide binding]; other site 1295826000146 KMSKS motif; other site 1295826000147 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1295826000148 putative phosphate acyltransferase; Provisional; Region: PRK05331 1295826000149 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 1295826000150 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1295826000151 active site 1295826000152 motif I; other site 1295826000153 motif II; other site 1295826000154 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1295826000155 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 1295826000156 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1295826000157 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1295826000158 ABC transporter; Region: ABC_tran_2; pfam12848 1295826000159 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1295826000160 yiaA/B two helix domain; Region: YiaAB; pfam05360 1295826000161 short chain dehydrogenase; Validated; Region: PRK06182 1295826000162 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1295826000163 NADP binding site [chemical binding]; other site 1295826000164 active site 1295826000165 steroid binding site; other site 1295826000166 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1295826000167 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1295826000168 short chain dehydrogenase; Validated; Region: PRK06182 1295826000169 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1295826000170 NADP binding site [chemical binding]; other site 1295826000171 active site 1295826000172 steroid binding site; other site 1295826000173 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1295826000174 Ligand Binding Site [chemical binding]; other site 1295826000175 Predicted esterase [General function prediction only]; Region: COG0400 1295826000176 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 1295826000177 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1295826000178 Zn binding site [ion binding]; other site 1295826000179 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 1295826000180 Zn binding site [ion binding]; other site 1295826000181 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 1295826000182 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1295826000183 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 1295826000184 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 1295826000185 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1295826000186 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1295826000187 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4705 1295826000188 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 1295826000189 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 1295826000190 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 1295826000191 ParB-like nuclease domain; Region: ParBc; pfam02195 1295826000192 KorB domain; Region: KorB; pfam08535 1295826000193 ATPase related to the helicase subunit of the Holliday junction resolvase [DNA replication, recombination, and repair]; Region: MGS1; COG2256 1295826000194 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1295826000195 Walker A motif; other site 1295826000196 ATP binding site [chemical binding]; other site 1295826000197 Walker B motif; other site 1295826000198 arginine finger; other site 1295826000199 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1295826000200 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1295826000201 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1295826000202 Coenzyme A binding pocket [chemical binding]; other site 1295826000203 Protein of unknown function (DUF3013); Region: DUF3013; pfam11217 1295826000204 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1295826000205 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1295826000206 Walker A/P-loop; other site 1295826000207 ATP binding site [chemical binding]; other site 1295826000208 Q-loop/lid; other site 1295826000209 ABC transporter signature motif; other site 1295826000210 Walker B; other site 1295826000211 D-loop; other site 1295826000212 H-loop/switch region; other site 1295826000213 ABC transporter; Region: ABC_tran_2; pfam12848 1295826000214 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1295826000215 Domain of unknown function (DUF1905); Region: DUF1905; pfam08922 1295826000216 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 1295826000217 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 1295826000218 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1295826000219 S-adenosylmethionine binding site [chemical binding]; other site 1295826000220 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 1295826000221 RNA methyltransferase, RsmE family; Region: TIGR00046 1295826000222 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1295826000223 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 1295826000224 putative active site [active] 1295826000225 putative metal binding site [ion binding]; other site 1295826000226 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1295826000227 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1295826000228 Zn2+ binding site [ion binding]; other site 1295826000229 Mg2+ binding site [ion binding]; other site 1295826000230 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1295826000231 synthetase active site [active] 1295826000232 NTP binding site [chemical binding]; other site 1295826000233 metal binding site [ion binding]; metal-binding site 1295826000234 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1295826000235 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1295826000236 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1295826000237 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1295826000238 Ligand binding site; other site 1295826000239 Putative Catalytic site; other site 1295826000240 DXD motif; other site 1295826000241 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 1295826000242 putative active site [active] 1295826000243 dimerization interface [polypeptide binding]; other site 1295826000244 putative tRNAtyr binding site [nucleotide binding]; other site 1295826000245 Phage minor structural protein GP20; Region: Phage_GP20; pfam06810 1295826000246 Predicted integral membrane protein [Function unknown]; Region: COG3548 1295826000247 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 1295826000248 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1295826000249 amino acid transporter; Region: 2A0306; TIGR00909 1295826000250 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 1295826000251 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1295826000252 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1295826000253 putative acyl-acceptor binding pocket; other site 1295826000254 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1295826000255 MarR family; Region: MarR_2; pfam12802 1295826000256 Acyl carrier protein phosphodiesterase [Lipid metabolism]; Region: AcpD; COG1182 1295826000257 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 1295826000258 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1295826000259 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1295826000260 nucleotide binding region [chemical binding]; other site 1295826000261 ATP-binding site [chemical binding]; other site 1295826000262 SEC-C motif; Region: SEC-C; pfam02810 1295826000263 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroG; COG0722 1295826000264 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1295826000265 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1295826000266 dimerization domain swap beta strand [polypeptide binding]; other site 1295826000267 regulatory protein interface [polypeptide binding]; other site 1295826000268 active site 1295826000269 regulatory phosphorylation site [posttranslational modification]; other site 1295826000270 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG0718 1295826000271 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1295826000272 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1295826000273 Malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate cycle, which allows certain organisms, like plants and fungi, to derive their...; Region: malate_synt; cl17217 1295826000274 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1295826000275 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1295826000276 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1295826000277 ATP binding site [chemical binding]; other site 1295826000278 Mg2+ binding site [ion binding]; other site 1295826000279 G-X-G motif; other site 1295826000280 conserved hypothetical integral membrane protein; Region: TIGR03766 1295826000281 argininosuccinate lyase; Provisional; Region: PRK00855 1295826000282 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1295826000283 active sites [active] 1295826000284 tetramer interface [polypeptide binding]; other site 1295826000285 drug efflux system protein MdtG; Provisional; Region: PRK09874 1295826000286 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1295826000287 putative substrate translocation pore; other site 1295826000288 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1295826000289 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1295826000290 WHG domain; Region: WHG; pfam13305 1295826000291 ribonuclease P; Reviewed; Region: rnpA; PRK00499 1295826000292 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 1295826000293 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 1295826000294 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 1295826000295 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1295826000296 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1295826000297 active site 1295826000298 catalytic tetrad [active] 1295826000299 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1295826000300 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1295826000301 non-specific DNA binding site [nucleotide binding]; other site 1295826000302 salt bridge; other site 1295826000303 sequence-specific DNA binding site [nucleotide binding]; other site 1295826000304 COMC family; Region: ComC; pfam03047 1295826000305 CAAX protease self-immunity; Region: Abi; pfam02517 1295826000306 hypothetical protein; Provisional; Region: PRK05473 1295826000307 hypothetical protein; Provisional; Region: PRK13678 1295826000308 Predicted integral membrane protein [Function unknown]; Region: COG3548 1295826000309 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 1295826000310 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1295826000311 NAD(P) binding site [chemical binding]; other site 1295826000312 active site 1295826000313 Uncharacterized protein conserved in bacteria (DUF2316); Region: DUF2316; pfam10078 1295826000314 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1295826000315 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1295826000316 glycogen branching enzyme; Provisional; Region: PRK12313 1295826000317 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 1295826000318 Alpha amylase catalytic domain found in bacterial and eukaryotic branching enzymes; Region: AmyAc_bac_euk_BE; cd11321 1295826000319 active site 1295826000320 catalytic site [active] 1295826000321 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 1295826000322 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1295826000323 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1295826000324 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 1295826000325 Collagen binding domain; Region: Collagen_bind; pfam05737 1295826000326 Collagen binding domain; Region: Collagen_bind; pfam05737 1295826000327 Collagen binding domain; Region: Collagen_bind; pfam05737 1295826000328 Cna protein B-type domain; Region: Cna_B; pfam05738 1295826000329 Cna protein B-type domain; Region: Cna_B; pfam05738 1295826000330 Cna protein B-type domain; Region: Cna_B; pfam05738 1295826000331 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 1295826000332 Cna protein B-type domain; Region: Cna_B; pfam05738 1295826000333 Cna protein B-type domain; Region: Cna_B; pfam05738 1295826000334 Cna protein B-type domain; Region: Cna_B; pfam05738 1295826000335 Cna protein B-type domain; Region: Cna_B; pfam05738 1295826000336 Cna protein B-type domain; Region: Cna_B; pfam05738 1295826000337 Cna protein B-type domain; Region: Cna_B; pfam05738 1295826000338 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 1295826000339 WxL domain surface cell wall-binding; Region: WxL; pfam13731 1295826000340 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1295826000341 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1295826000342 non-specific DNA binding site [nucleotide binding]; other site 1295826000343 salt bridge; other site 1295826000344 sequence-specific DNA binding site [nucleotide binding]; other site 1295826000345 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 1295826000346 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 1295826000347 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1295826000348 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1295826000349 putative substrate translocation pore; other site 1295826000350 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 1295826000351 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 1295826000352 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; cl17626 1295826000353 aminotransferase AlaT; Validated; Region: PRK09265 1295826000354 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1295826000355 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1295826000356 homodimer interface [polypeptide binding]; other site 1295826000357 catalytic residue [active] 1295826000358 Pleiotropic transcriptional repressor [Transcription]; Region: CodY; COG4465 1295826000359 CodY GAF-like domain; Region: CodY; pfam06018 1295826000360 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 1295826000361 Asp-tRNAAsn/Glu-tRNAGln amidotransferase C subunit [Translation, ribosomal structure and biogenesis]; Region: GatC; COG0721 1295826000362 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1295826000363 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 1295826000364 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 1295826000365 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 1295826000366 nudix motif; other site 1295826000367 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 1295826000368 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 1295826000369 GatB domain; Region: GatB_Yqey; pfam02637 1295826000370 amidase; Provisional; Region: PRK06529 1295826000371 Amidase; Region: Amidase; cl11426 1295826000372 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 1295826000373 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1295826000374 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1295826000375 DNA-binding site [nucleotide binding]; DNA binding site 1295826000376 RNA-binding motif; other site 1295826000377 Rhomboid family; Region: Rhomboid; pfam01694 1295826000378 Domain of unknown function (DUF3284); Region: DUF3284; pfam11687 1295826000379 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1295826000380 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1295826000381 active site 1295826000382 metal binding site [ion binding]; metal-binding site 1295826000383 Uncharacterized conserved protein [Function unknown]; Region: COG3589 1295826000384 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 1295826000385 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 1295826000386 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1295826000387 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1295826000388 trimer interface [polypeptide binding]; other site 1295826000389 active site 1295826000390 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1295826000391 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 1295826000392 active site 1295826000393 metal binding site [ion binding]; metal-binding site 1295826000394 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1295826000395 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4470 1295826000396 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 1295826000397 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1295826000398 FeS/SAM binding site; other site 1295826000399 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 1295826000400 dimer interface [polypeptide binding]; other site 1295826000401 FMN binding site [chemical binding]; other site 1295826000402 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1295826000403 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1295826000404 substrate binding pocket [chemical binding]; other site 1295826000405 chain length determination region; other site 1295826000406 substrate-Mg2+ binding site; other site 1295826000407 catalytic residues [active] 1295826000408 aspartate-rich region 1; other site 1295826000409 active site lid residues [active] 1295826000410 aspartate-rich region 2; other site 1295826000411 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 1295826000412 UbiA prenyltransferase family; Region: UbiA; pfam01040 1295826000413 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 1295826000414 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 1295826000415 G1 box; other site 1295826000416 GTP/Mg2+ binding site [chemical binding]; other site 1295826000417 Switch I region; other site 1295826000418 G2 box; other site 1295826000419 G3 box; other site 1295826000420 Switch II region; other site 1295826000421 G4 box; other site 1295826000422 G5 box; other site 1295826000423 Nucleoside recognition; Region: Gate; pfam07670 1295826000424 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 1295826000425 Nucleoside recognition; Region: Gate; pfam07670 1295826000426 FeoA domain; Region: FeoA; pfam04023 1295826000427 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 1295826000428 methionine sulfoxide reductase B; Provisional; Region: PRK00222 1295826000429 SelR domain; Region: SelR; pfam01641 1295826000430 Predicted kinase related to dihydroxyacetone kinase [General function prediction only]; Region: COG1461 1295826000431 DAK2 domain; Region: Dak2; pfam02734 1295826000432 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 1295826000433 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1295826000434 Uncharacterized membrane-bound protein conserved in bacteria [Function unknown]; Region: COG4858 1295826000435 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 1295826000436 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 1295826000437 substrate binding site; other site 1295826000438 tetramer interface; other site 1295826000439 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 1295826000440 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 1295826000441 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1295826000442 NAD binding site [chemical binding]; other site 1295826000443 substrate binding site [chemical binding]; other site 1295826000444 homodimer interface [polypeptide binding]; other site 1295826000445 active site 1295826000446 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 1295826000447 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 1295826000448 NADP binding site [chemical binding]; other site 1295826000449 active site 1295826000450 putative substrate binding site [chemical binding]; other site 1295826000451 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 1295826000452 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1295826000453 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 1295826000454 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 1295826000455 Walker A/P-loop; other site 1295826000456 ATP binding site [chemical binding]; other site 1295826000457 Q-loop/lid; other site 1295826000458 ABC transporter signature motif; other site 1295826000459 Walker B; other site 1295826000460 D-loop; other site 1295826000461 H-loop/switch region; other site 1295826000462 Predicted membrane protein (DUF2142); Region: DUF2142; pfam09913 1295826000463 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1295826000464 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1295826000465 active site 1295826000466 Rhamnan synthesis protein F; Region: RgpF; pfam05045 1295826000467 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1295826000468 active site 1295826000469 Protein of unknown function (DUF3184); Region: DUF3184; pfam11380 1295826000470 beta-1,6-galactofuranosyltransferase; Provisional; Region: PRK09814 1295826000471 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1295826000472 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 1295826000473 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1295826000474 UDP-galactopyranose mutase; Region: GLF; pfam03275 1295826000475 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1295826000476 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 1295826000477 Predicted membrane protein (DUF2142); Region: DUF2142; pfam09913 1295826000478 AtlA is an autolysin found in Gram-positive lactic acid bacteria that degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. This family includes the AtlA and Aml...; Region: GH25_AtlA-like; cd06522 1295826000479 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 1295826000480 active site 1295826000481 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 1295826000482 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1295826000483 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 1295826000484 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1295826000485 active site 1295826000486 GTPase YqeH; Provisional; Region: PRK13796 1295826000487 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 1295826000488 GTP/Mg2+ binding site [chemical binding]; other site 1295826000489 G4 box; other site 1295826000490 G5 box; other site 1295826000491 G1 box; other site 1295826000492 Switch I region; other site 1295826000493 G2 box; other site 1295826000494 G3 box; other site 1295826000495 Switch II region; other site 1295826000496 hypothetical protein; Provisional; Region: PRK09273 1295826000497 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 1295826000498 GTPases [General function prediction only]; Region: HflX; COG2262 1295826000499 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1295826000500 HflX GTPase family; Region: HflX; cd01878 1295826000501 G1 box; other site 1295826000502 GTP/Mg2+ binding site [chemical binding]; other site 1295826000503 Switch I region; other site 1295826000504 G2 box; other site 1295826000505 G3 box; other site 1295826000506 Switch II region; other site 1295826000507 G4 box; other site 1295826000508 G5 box; other site 1295826000509 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1295826000510 Coenzyme A binding pocket [chemical binding]; other site 1295826000511 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 1295826000512 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 1295826000513 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1295826000514 active site 1295826000515 (T/H)XGH motif; other site 1295826000516 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1295826000517 Zn2+ binding site [ion binding]; other site 1295826000518 Mg2+ binding site [ion binding]; other site 1295826000519 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1295826000520 Coenzyme A binding pocket [chemical binding]; other site 1295826000521 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 1295826000522 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 1295826000523 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1295826000524 S-adenosylmethionine binding site [chemical binding]; other site 1295826000525 hypothetical protein; Provisional; Region: PRK13670 1295826000526 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; pfam05636 1295826000527 hypothetical protein; Provisional; Region: PRK12378 1295826000528 Uncharacterized conserved protein [Function unknown]; Region: COG4832 1295826000529 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 1295826000530 ligand binding site [chemical binding]; other site 1295826000531 active site 1295826000532 UGI interface [polypeptide binding]; other site 1295826000533 catalytic site [active] 1295826000534 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 1295826000535 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1295826000536 putative NAD(P) binding site [chemical binding]; other site 1295826000537 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1295826000538 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1295826000539 NAD(P) binding site [chemical binding]; other site 1295826000540 active site 1295826000541 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1295826000542 putative substrate translocation pore; other site 1295826000543 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1295826000544 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 1295826000545 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1295826000546 DNA binding residues [nucleotide binding] 1295826000547 putative dimer interface [polypeptide binding]; other site 1295826000548 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 1295826000549 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1295826000550 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1295826000551 active site 1295826000552 motif I; other site 1295826000553 motif II; other site 1295826000554 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1295826000555 phosphoglycerate kinase; Provisional; Region: pgk; PRK00073 1295826000556 Phosphoglycerate kinase; Region: PGK; pfam00162 1295826000557 substrate binding site [chemical binding]; other site 1295826000558 hinge regions; other site 1295826000559 ADP binding site [chemical binding]; other site 1295826000560 catalytic site [active] 1295826000561 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 1295826000562 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1295826000563 motif II; other site 1295826000564 DhaKLM operon coactivator DhaQ; Provisional; Region: PRK14483 1295826000565 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 1295826000566 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 1295826000567 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 1295826000568 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 1295826000569 dihydroxyacetone kinase, phosphoprotein-dependent, L subunit; Region: dha_L_ycgS; TIGR02365 1295826000570 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3412 1295826000571 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 1295826000572 amphipathic channel; other site 1295826000573 Asn-Pro-Ala signature motifs; other site 1295826000574 Radical SAM superfamily; Region: Radical_SAM; pfam04055 1295826000575 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1295826000576 FeS/SAM binding site; other site 1295826000577 Dipeptidase [Amino acid transport and metabolism]; Region: PepD; COG4690 1295826000578 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1295826000579 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1295826000580 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 1295826000581 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 1295826000582 putative RNA binding site [nucleotide binding]; other site 1295826000583 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1295826000584 Uncharacterized protein conserved in bacteria [Carbohydrate transport and metabolism]; Region: Fbp; COG3855 1295826000585 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1295826000586 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1295826000587 putative substrate binding site [chemical binding]; other site 1295826000588 putative ATP binding site [chemical binding]; other site 1295826000589 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1295826000590 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1295826000591 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1295826000592 Walker A/P-loop; other site 1295826000593 ATP binding site [chemical binding]; other site 1295826000594 Q-loop/lid; other site 1295826000595 ABC transporter signature motif; other site 1295826000596 Walker B; other site 1295826000597 D-loop; other site 1295826000598 H-loop/switch region; other site 1295826000599 S-ribosylhomocysteinase; Provisional; Region: PRK02260 1295826000600 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 1295826000601 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1295826000602 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1295826000603 active site 1295826000604 catalytic tetrad [active] 1295826000605 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 1295826000606 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1295826000607 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1295826000608 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1295826000609 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 1295826000610 ATP cone domain; Region: ATP-cone; pfam03477 1295826000611 Class III ribonucleotide reductase; Region: RNR_III; cd01675 1295826000612 effector binding site; other site 1295826000613 active site 1295826000614 Zn binding site [ion binding]; other site 1295826000615 glycine loop; other site 1295826000616 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 1295826000617 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1295826000618 FeS/SAM binding site; other site 1295826000619 Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; pfam10087 1295826000620 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13642 1295826000621 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1295826000622 Walker A/P-loop; other site 1295826000623 ATP binding site [chemical binding]; other site 1295826000624 Q-loop/lid; other site 1295826000625 ABC transporter signature motif; other site 1295826000626 Walker B; other site 1295826000627 D-loop; other site 1295826000628 H-loop/switch region; other site 1295826000629 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13643 1295826000630 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1295826000631 Walker A/P-loop; other site 1295826000632 ATP binding site [chemical binding]; other site 1295826000633 Q-loop/lid; other site 1295826000634 ABC transporter signature motif; other site 1295826000635 Walker B; other site 1295826000636 D-loop; other site 1295826000637 H-loop/switch region; other site 1295826000638 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1295826000639 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1295826000640 active site 1295826000641 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1295826000642 M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670 1295826000643 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1295826000644 metal binding site [ion binding]; metal-binding site 1295826000645 putative dimer interface [polypeptide binding]; other site 1295826000646 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1295826000647 Catalytic NodB homology domain of Clostridium thermocellum acetylxylan esterase and its bacterial homologs; Region: CE4_CtAXE_like; cd10954 1295826000648 NodB motif; other site 1295826000649 active site 1295826000650 catalytic site [active] 1295826000651 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1295826000652 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1295826000653 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1295826000654 RNA binding surface [nucleotide binding]; other site 1295826000655 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 1295826000656 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 1295826000657 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 1295826000658 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 1295826000659 RNA binding site [nucleotide binding]; other site 1295826000660 SprT homologues; Region: SprT; cl01182 1295826000661 hypothetical protein; Provisional; Region: PRK04351 1295826000662 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 1295826000663 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 1295826000664 active site 1295826000665 purine riboside binding site [chemical binding]; other site 1295826000666 SnoaL-like domain; Region: SnoaL_4; pfam13577 1295826000667 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 1295826000668 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1295826000669 DNA binding residues [nucleotide binding] 1295826000670 putative dimer interface [polypeptide binding]; other site 1295826000671 hypothetical protein; Provisional; Region: PRK13667 1295826000672 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1295826000673 Glycoprotease family; Region: Peptidase_M22; pfam00814 1295826000674 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1295826000675 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1295826000676 Coenzyme A binding pocket [chemical binding]; other site 1295826000677 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1295826000678 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1295826000679 Coenzyme A binding pocket [chemical binding]; other site 1295826000680 UGMP family protein; Validated; Region: PRK09604 1295826000681 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 1295826000682 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 1295826000683 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 1295826000684 Walker A/P-loop; other site 1295826000685 ATP binding site [chemical binding]; other site 1295826000686 Q-loop/lid; other site 1295826000687 ABC transporter signature motif; other site 1295826000688 Walker B; other site 1295826000689 D-loop; other site 1295826000690 H-loop/switch region; other site 1295826000691 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 1295826000692 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1295826000693 dimer interface [polypeptide binding]; other site 1295826000694 conserved gate region; other site 1295826000695 putative PBP binding loops; other site 1295826000696 ABC-ATPase subunit interface; other site 1295826000697 ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport and metabolism]; Region: COG3639 1295826000698 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1295826000699 dimer interface [polypeptide binding]; other site 1295826000700 conserved gate region; other site 1295826000701 ABC-ATPase subunit interface; other site 1295826000702 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1295826000703 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 1295826000704 active site 1295826000705 metal binding site [ion binding]; metal-binding site 1295826000706 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1295826000707 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 1295826000708 dimer interface [polypeptide binding]; other site 1295826000709 catalytic triad [active] 1295826000710 peroxidatic and resolving cysteines [active] 1295826000711 Aminopeptidase N [Amino acid transport and metabolism]; Region: PepN; COG0308 1295826000712 Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601 1295826000713 Zn binding site [ion binding]; other site 1295826000714 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1295826000715 putative substrate translocation pore; other site 1295826000716 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1295826000717 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1295826000718 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1295826000719 Cation efflux family; Region: Cation_efflux; pfam01545 1295826000720 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1295826000721 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1295826000722 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1295826000723 Walker A/P-loop; other site 1295826000724 ATP binding site [chemical binding]; other site 1295826000725 Q-loop/lid; other site 1295826000726 ABC transporter signature motif; other site 1295826000727 Walker B; other site 1295826000728 D-loop; other site 1295826000729 H-loop/switch region; other site 1295826000730 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1295826000731 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1295826000732 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1295826000733 Walker A/P-loop; other site 1295826000734 ATP binding site [chemical binding]; other site 1295826000735 Q-loop/lid; other site 1295826000736 ABC transporter signature motif; other site 1295826000737 Walker B; other site 1295826000738 D-loop; other site 1295826000739 H-loop/switch region; other site 1295826000740 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1295826000741 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1295826000742 hinge; other site 1295826000743 active site 1295826000744 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4443 1295826000745 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 1295826000746 putative deacylase active site [active] 1295826000747 Predicted membrane protein [Function unknown]; Region: COG3859 1295826000748 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1295826000749 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1295826000750 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1295826000751 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1295826000752 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1295826000753 acetoin reductases; Region: 23BDH; TIGR02415 1295826000754 NAD(P) binding site [chemical binding]; other site 1295826000755 active site 1295826000756 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1295826000757 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1295826000758 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 1295826000759 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1295826000760 Walker A/P-loop; other site 1295826000761 ATP binding site [chemical binding]; other site 1295826000762 Q-loop/lid; other site 1295826000763 ABC transporter signature motif; other site 1295826000764 Walker B; other site 1295826000765 D-loop; other site 1295826000766 H-loop/switch region; other site 1295826000767 NIL domain; Region: NIL; pfam09383 1295826000768 ABC-type metal ion transport system, permease component [Inorganic ion transport and metabolism]; Region: AbcD; COG2011 1295826000769 hypothetical protein; Provisional; Region: PRK13661 1295826000770 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1295826000771 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1295826000772 Walker A/P-loop; other site 1295826000773 ATP binding site [chemical binding]; other site 1295826000774 Q-loop/lid; other site 1295826000775 ABC transporter signature motif; other site 1295826000776 Walker B; other site 1295826000777 D-loop; other site 1295826000778 H-loop/switch region; other site 1295826000779 ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558 1295826000780 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1295826000781 Walker A/P-loop; other site 1295826000782 ATP binding site [chemical binding]; other site 1295826000783 Q-loop/lid; other site 1295826000784 ABC transporter signature motif; other site 1295826000785 Walker B; other site 1295826000786 D-loop; other site 1295826000787 H-loop/switch region; other site 1295826000788 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1295826000789 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1295826000790 Walker A/P-loop; other site 1295826000791 ATP binding site [chemical binding]; other site 1295826000792 Q-loop/lid; other site 1295826000793 ABC transporter signature motif; other site 1295826000794 Walker B; other site 1295826000795 D-loop; other site 1295826000796 H-loop/switch region; other site 1295826000797 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1295826000798 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1295826000799 ABC-ATPase subunit interface; other site 1295826000800 dimer interface [polypeptide binding]; other site 1295826000801 putative PBP binding regions; other site 1295826000802 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1295826000803 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1295826000804 ABC-ATPase subunit interface; other site 1295826000805 dimer interface [polypeptide binding]; other site 1295826000806 putative PBP binding regions; other site 1295826000807 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 1295826000808 putative ligand binding residues [chemical binding]; other site 1295826000809 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1295826000810 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1295826000811 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1295826000812 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1295826000813 dimerization interface [polypeptide binding]; other site 1295826000814 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1295826000815 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1295826000816 putative substrate translocation pore; other site 1295826000817 Predicted transcriptional regulators [Transcription]; Region: COG1733 1295826000818 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1295826000819 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 1295826000820 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1295826000821 putative metal binding site [ion binding]; other site 1295826000822 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1295826000823 catalytic core [active] 1295826000824 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1295826000825 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 1295826000826 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 1295826000827 catalytic residue [active] 1295826000828 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 1295826000829 catalytic residues [active] 1295826000830 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1295826000831 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1295826000832 recombination protein RecR; Reviewed; Region: recR; PRK00076 1295826000833 RecR protein; Region: RecR; pfam02132 1295826000834 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1295826000835 putative active site [active] 1295826000836 putative metal-binding site [ion binding]; other site 1295826000837 tetramer interface [polypeptide binding]; other site 1295826000838 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 1295826000839 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1295826000840 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 1295826000841 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 1295826000842 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1295826000843 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1295826000844 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1295826000845 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1295826000846 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1295826000847 peptide binding site [polypeptide binding]; other site 1295826000848 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1295826000849 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1295826000850 dimer interface [polypeptide binding]; other site 1295826000851 conserved gate region; other site 1295826000852 putative PBP binding loops; other site 1295826000853 ABC-ATPase subunit interface; other site 1295826000854 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1295826000855 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1295826000856 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1295826000857 dimer interface [polypeptide binding]; other site 1295826000858 conserved gate region; other site 1295826000859 putative PBP binding loops; other site 1295826000860 ABC-ATPase subunit interface; other site 1295826000861 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1295826000862 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1295826000863 Walker A/P-loop; other site 1295826000864 ATP binding site [chemical binding]; other site 1295826000865 Q-loop/lid; other site 1295826000866 ABC transporter signature motif; other site 1295826000867 Walker B; other site 1295826000868 D-loop; other site 1295826000869 H-loop/switch region; other site 1295826000870 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1295826000871 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1295826000872 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1295826000873 Walker A/P-loop; other site 1295826000874 ATP binding site [chemical binding]; other site 1295826000875 Q-loop/lid; other site 1295826000876 ABC transporter signature motif; other site 1295826000877 Walker B; other site 1295826000878 D-loop; other site 1295826000879 H-loop/switch region; other site 1295826000880 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1295826000881 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 1295826000882 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 1295826000883 G1 box; other site 1295826000884 putative GEF interaction site [polypeptide binding]; other site 1295826000885 GTP/Mg2+ binding site [chemical binding]; other site 1295826000886 Switch I region; other site 1295826000887 G2 box; other site 1295826000888 G3 box; other site 1295826000889 Switch II region; other site 1295826000890 G4 box; other site 1295826000891 G5 box; other site 1295826000892 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 1295826000893 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 1295826000894 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1295826000895 ATP binding site [chemical binding]; other site 1295826000896 Mg++ binding site [ion binding]; other site 1295826000897 motif III; other site 1295826000898 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1295826000899 nucleotide binding region [chemical binding]; other site 1295826000900 ATP-binding site [chemical binding]; other site 1295826000901 GTPase Era; Reviewed; Region: era; PRK00089 1295826000902 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1295826000903 G1 box; other site 1295826000904 GTP/Mg2+ binding site [chemical binding]; other site 1295826000905 Switch I region; other site 1295826000906 G2 box; other site 1295826000907 Switch II region; other site 1295826000908 G3 box; other site 1295826000909 G4 box; other site 1295826000910 G5 box; other site 1295826000911 KH domain; Region: KH_2; pfam07650 1295826000912 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 1295826000913 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1295826000914 DNA binding site [nucleotide binding] 1295826000915 catalytic residue [active] 1295826000916 H2TH interface [polypeptide binding]; other site 1295826000917 putative catalytic residues [active] 1295826000918 turnover-facilitating residue; other site 1295826000919 intercalation triad [nucleotide binding]; other site 1295826000920 8OG recognition residue [nucleotide binding]; other site 1295826000921 putative reading head residues; other site 1295826000922 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1295826000923 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1295826000924 recombinase A; Provisional; Region: recA; PRK09354 1295826000925 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1295826000926 hexamer interface [polypeptide binding]; other site 1295826000927 Walker A motif; other site 1295826000928 ATP binding site [chemical binding]; other site 1295826000929 Walker B motif; other site 1295826000930 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1295826000931 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1295826000932 Protein of unknown function (DUF964); Region: DUF964; cl01483 1295826000933 Uncharacterized protein conserved in bacteria (DUF2129); Region: DUF2129; pfam09902 1295826000934 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 1295826000935 putative active site [active] 1295826000936 putative metal binding residues [ion binding]; other site 1295826000937 signature motif; other site 1295826000938 putative triphosphate binding site [ion binding]; other site 1295826000939 Protein of unknown function (DUF817); Region: DUF817; pfam05675 1295826000940 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1295826000941 synthetase active site [active] 1295826000942 NTP binding site [chemical binding]; other site 1295826000943 metal binding site [ion binding]; metal-binding site 1295826000944 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 1295826000945 ATP-NAD kinase; Region: NAD_kinase; pfam01513 1295826000946 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1295826000947 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1295826000948 active site 1295826000949 lysine transporter; Provisional; Region: PRK10836 1295826000950 Predicted flavoprotein [General function prediction only]; Region: COG0431 1295826000951 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1295826000952 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1295826000953 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1295826000954 dimer interface [polypeptide binding]; other site 1295826000955 putative anticodon binding site; other site 1295826000956 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 1295826000957 motif 1; other site 1295826000958 active site 1295826000959 motif 2; other site 1295826000960 motif 3; other site 1295826000961 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1295826000962 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 1295826000963 LysR substrate binding domain; Region: LysR_substrate; pfam03466 1295826000964 dimerization interface [polypeptide binding]; other site 1295826000965 Conserved hypothetical protein 698; Region: Cons_hypoth698; pfam03601 1295826000966 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 1295826000967 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 1295826000968 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1295826000969 NAD binding site [chemical binding]; other site 1295826000970 dimer interface [polypeptide binding]; other site 1295826000971 substrate binding site [chemical binding]; other site 1295826000972 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1295826000973 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1295826000974 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1295826000975 dimerization interface [polypeptide binding]; other site 1295826000976 C4-dicarboxylate transporters of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_C4-dicarb_trans; cd09325 1295826000977 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 1295826000978 gating phenylalanine in ion channel; other site 1295826000979 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 1295826000980 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 1295826000981 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 1295826000982 Ligand Binding Site [chemical binding]; other site 1295826000983 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1295826000984 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1295826000985 putative substrate translocation pore; other site 1295826000986 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 1295826000987 OsmC-like protein; Region: OsmC; cl00767 1295826000988 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1295826000989 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1295826000990 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1295826000991 active site 1295826000992 HIGH motif; other site 1295826000993 dimer interface [polypeptide binding]; other site 1295826000994 KMSKS motif; other site 1295826000995 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1295826000996 RNA binding surface [nucleotide binding]; other site 1295826000997 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1295826000998 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 1295826000999 oligomer interface [polypeptide binding]; other site 1295826001000 active site 1295826001001 metal binding site [ion binding]; metal-binding site 1295826001002 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1295826001003 catalytic residues [active] 1295826001004 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1295826001005 putative tRNA-binding site [nucleotide binding]; other site 1295826001006 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 1295826001007 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1295826001008 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1295826001009 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1295826001010 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1295826001011 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1295826001012 dimer interface [polypeptide binding]; other site 1295826001013 ssDNA binding site [nucleotide binding]; other site 1295826001014 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1295826001015 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1295826001016 oligomerisation interface [polypeptide binding]; other site 1295826001017 mobile loop; other site 1295826001018 roof hairpin; other site 1295826001019 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1295826001020 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1295826001021 ring oligomerisation interface [polypeptide binding]; other site 1295826001022 ATP/Mg binding site [chemical binding]; other site 1295826001023 stacking interactions; other site 1295826001024 hinge regions; other site 1295826001025 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 1295826001026 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1295826001027 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1295826001028 active site 1295826001029 phosphorylation site [posttranslational modification] 1295826001030 intermolecular recognition site; other site 1295826001031 dimerization interface [polypeptide binding]; other site 1295826001032 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1295826001033 DNA binding site [nucleotide binding] 1295826001034 thymidylate kinase; Validated; Region: tmk; PRK00698 1295826001035 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1295826001036 TMP-binding site; other site 1295826001037 ATP-binding site [chemical binding]; other site 1295826001038 PSP1 C-terminal conserved region; Region: PSP1; cl00770 1295826001039 Regulator of replication initiation timing [Replication, recombination, and repair]; Region: COG4467 1295826001040 Predicted methyltransferases [General function prediction only]; Region: COG0313 1295826001041 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1295826001042 putative SAM binding site [chemical binding]; other site 1295826001043 putative homodimer interface [polypeptide binding]; other site 1295826001044 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1295826001045 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1295826001046 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1295826001047 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 1295826001048 Walker A/P-loop; other site 1295826001049 ATP binding site [chemical binding]; other site 1295826001050 Q-loop/lid; other site 1295826001051 ABC transporter signature motif; other site 1295826001052 Walker B; other site 1295826001053 D-loop; other site 1295826001054 H-loop/switch region; other site 1295826001055 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 1295826001056 MarR family; Region: MarR_2; pfam12802 1295826001057 mevalonate kinase; Region: mevalon_kin; TIGR00549 1295826001058 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1295826001059 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1295826001060 Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407 1295826001061 diphosphomevalonate decarboxylase; Region: PLN02407 1295826001062 Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577 1295826001063 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1295826001064 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1295826001065 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 1295826001066 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 1295826001067 homotetramer interface [polypeptide binding]; other site 1295826001068 FMN binding site [chemical binding]; other site 1295826001069 homodimer contacts [polypeptide binding]; other site 1295826001070 putative active site [active] 1295826001071 putative substrate binding site [chemical binding]; other site 1295826001072 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1295826001073 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1295826001074 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1295826001075 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 1295826001076 Carbon starvation protein CstA; Region: CstA; pfam02554 1295826001077 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 1295826001078 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1295826001079 Predicted transcriptional regulator [Transcription]; Region: COG2378 1295826001080 HTH domain; Region: HTH_11; pfam08279 1295826001081 WYL domain; Region: WYL; pfam13280 1295826001082 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1295826001083 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1295826001084 ATP binding site [chemical binding]; other site 1295826001085 Mg++ binding site [ion binding]; other site 1295826001086 motif III; other site 1295826001087 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1295826001088 nucleotide binding region [chemical binding]; other site 1295826001089 ATP-binding site [chemical binding]; other site 1295826001090 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1295826001091 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1295826001092 putative active site [active] 1295826001093 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1295826001094 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1295826001095 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1295826001096 putative active site [active] 1295826001097 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 1295826001098 active site 1295826001099 P-loop; other site 1295826001100 phosphorylation site [posttranslational modification] 1295826001101 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 1295826001102 active site 1295826001103 methionine cluster; other site 1295826001104 phosphorylation site [posttranslational modification] 1295826001105 metal binding site [ion binding]; metal-binding site 1295826001106 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1295826001107 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1295826001108 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1295826001109 putative active site [active] 1295826001110 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 1295826001111 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1295826001112 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 1295826001113 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1295826001114 nucleotide binding pocket [chemical binding]; other site 1295826001115 K-X-D-G motif; other site 1295826001116 catalytic site [active] 1295826001117 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1295826001118 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1295826001119 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1295826001120 Dimer interface [polypeptide binding]; other site 1295826001121 BRCT sequence motif; other site 1295826001122 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1295826001123 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1295826001124 Walker A/P-loop; other site 1295826001125 ATP binding site [chemical binding]; other site 1295826001126 Q-loop/lid; other site 1295826001127 ABC transporter signature motif; other site 1295826001128 Walker B; other site 1295826001129 D-loop; other site 1295826001130 H-loop/switch region; other site 1295826001131 TOBE domain; Region: TOBE_2; pfam08402 1295826001132 Uncharacterized conserved protein [Function unknown]; Region: COG1624 1295826001133 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 1295826001134 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 1295826001135 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1295826001136 active site 1295826001137 substrate binding site [chemical binding]; other site 1295826001138 metal binding site [ion binding]; metal-binding site 1295826001139 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1295826001140 DNA-binding site [nucleotide binding]; DNA binding site 1295826001141 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 1295826001142 UTRA domain; Region: UTRA; pfam07702 1295826001143 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1295826001144 HPr interaction site; other site 1295826001145 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1295826001146 active site 1295826001147 phosphorylation site [posttranslational modification] 1295826001148 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 1295826001149 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1295826001150 active site turn [active] 1295826001151 phosphorylation site [posttranslational modification] 1295826001152 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1295826001153 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 1295826001154 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 1295826001155 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 1295826001156 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 1295826001157 beta-phosphoglucomutase; Region: bPGM; TIGR01990 1295826001158 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1295826001159 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1295826001160 motif II; other site 1295826001161 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1295826001162 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1295826001163 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 1295826001164 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1295826001165 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1295826001166 Coenzyme A binding pocket [chemical binding]; other site 1295826001167 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1295826001168 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1295826001169 dimer interface [polypeptide binding]; other site 1295826001170 substrate binding site [chemical binding]; other site 1295826001171 ATP binding site [chemical binding]; other site 1295826001172 Predicted membrane protein [Function unknown]; Region: COG4720 1295826001173 hypothetical protein; Provisional; Region: PRK13690 1295826001174 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 1295826001175 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1295826001176 catalytic residue [active] 1295826001177 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 1295826001178 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 1295826001179 NAD(P) binding site [chemical binding]; other site 1295826001180 LDH/MDH dimer interface [polypeptide binding]; other site 1295826001181 substrate binding site [chemical binding]; other site 1295826001182 Predicted membrane protein [Function unknown]; Region: COG4420 1295826001183 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 1295826001184 Nucleoside 2-deoxyribosyltransferase [Nucleotide transport and metabolism]; Region: COG3613 1295826001185 Possible lysine decarboxylase; Region: Lysine_decarbox; pfam03641 1295826001186 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 1295826001187 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 1295826001188 Substrate-binding site [chemical binding]; other site 1295826001189 Substrate specificity [chemical binding]; other site 1295826001190 Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529 1295826001191 putative active site [active] 1295826001192 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK07279 1295826001193 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 1295826001194 active site 1295826001195 PHP Thumb interface [polypeptide binding]; other site 1295826001196 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1295826001197 generic binding surface II; other site 1295826001198 generic binding surface I; other site 1295826001199 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 1295826001200 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 1295826001201 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 1295826001202 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1295826001203 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1295826001204 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1295826001205 dimer interface [polypeptide binding]; other site 1295826001206 conserved gate region; other site 1295826001207 putative PBP binding loops; other site 1295826001208 ABC-ATPase subunit interface; other site 1295826001209 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 1295826001210 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 1295826001211 EDD domain protein, DegV family; Region: DegV; TIGR00762 1295826001212 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1295826001213 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 1295826001214 active site 1295826001215 catalytic triad [active] 1295826001216 oxyanion hole [active] 1295826001217 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1295826001218 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 1295826001219 Uncharacterized protein conserved in bacteria (DUF2140); Region: DUF2140; cl11548 1295826001220 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1295826001221 IHF dimer interface [polypeptide binding]; other site 1295826001222 IHF - DNA interface [nucleotide binding]; other site 1295826001223 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 1295826001224 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1295826001225 Coenzyme A binding pocket [chemical binding]; other site 1295826001226 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 1295826001227 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 1295826001228 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1295826001229 DNA binding site [nucleotide binding] 1295826001230 active site 1295826001231 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 1295826001232 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 1295826001233 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1295826001234 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1295826001235 N-acetyltransferase; Region: Acetyltransf_2; cl00949 1295826001236 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1295826001237 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1295826001238 Walker A/P-loop; other site 1295826001239 ATP binding site [chemical binding]; other site 1295826001240 Q-loop/lid; other site 1295826001241 ABC transporter signature motif; other site 1295826001242 Walker B; other site 1295826001243 D-loop; other site 1295826001244 H-loop/switch region; other site 1295826001245 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1295826001246 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1295826001247 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1295826001248 LytTr DNA-binding domain; Region: LytTR; smart00850 1295826001249 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1295826001250 NlpC/P60 family; Region: NLPC_P60; cl17555 1295826001251 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1295826001252 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1295826001253 peptide binding site [polypeptide binding]; other site 1295826001254 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1295826001255 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1295826001256 dimer interface [polypeptide binding]; other site 1295826001257 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1295826001258 catalytic residue [active] 1295826001259 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 1295826001260 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1295826001261 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1295826001262 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1295826001263 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1295826001264 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 1295826001265 hypothetical protein; Provisional; Region: PRK13660 1295826001266 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 1295826001267 ArsC family; Region: ArsC; pfam03960 1295826001268 putative catalytic residues [active] 1295826001269 thiol/disulfide switch; other site 1295826001270 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1295826001271 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 1295826001272 active site 1295826001273 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1295826001274 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1295826001275 hinge; other site 1295826001276 active site 1295826001277 trigger factor; Provisional; Region: tig; PRK01490 1295826001278 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1295826001279 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1295826001280 DNA primase, catalytic core; Region: dnaG; TIGR01391 1295826001281 CHC2 zinc finger; Region: zf-CHC2; pfam01807 1295826001282 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1295826001283 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1295826001284 active site 1295826001285 metal binding site [ion binding]; metal-binding site 1295826001286 interdomain interaction site; other site 1295826001287 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 1295826001288 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 1295826001289 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1295826001290 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1295826001291 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1295826001292 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1295826001293 DNA binding residues [nucleotide binding] 1295826001294 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1295826001295 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1295826001296 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1295826001297 putative active site [active] 1295826001298 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 1295826001299 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1295826001300 putative substrate translocation pore; other site 1295826001301 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1295826001302 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 1295826001303 Double zinc ribbon; Region: DZR; pfam12773 1295826001304 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1295826001305 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1295826001306 Walker A motif; other site 1295826001307 ATP binding site [chemical binding]; other site 1295826001308 Walker B motif; other site 1295826001309 arginine finger; other site 1295826001310 UvrB/uvrC motif; Region: UVR; pfam02151 1295826001311 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1295826001312 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1295826001313 Walker A motif; other site 1295826001314 ATP binding site [chemical binding]; other site 1295826001315 Walker B motif; other site 1295826001316 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1295826001317 Predicted transcriptional regulator [Transcription]; Region: COG1959 1295826001318 Transcriptional regulator; Region: Rrf2; pfam02082 1295826001319 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1295826001320 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 1295826001321 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1295826001322 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1295826001323 active site 1295826001324 catalytic residues [active] 1295826001325 metal binding site [ion binding]; metal-binding site 1295826001326 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 1295826001327 putative active site [active] 1295826001328 Ap4A binding site [chemical binding]; other site 1295826001329 nudix motif; other site 1295826001330 putative metal binding site [ion binding]; other site 1295826001331 excinuclease ABC subunit B; Provisional; Region: PRK05298 1295826001332 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1295826001333 ATP binding site [chemical binding]; other site 1295826001334 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1295826001335 nucleotide binding region [chemical binding]; other site 1295826001336 ATP-binding site [chemical binding]; other site 1295826001337 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1295826001338 UvrB/uvrC motif; Region: UVR; pfam02151 1295826001339 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1295826001340 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1295826001341 substrate binding pocket [chemical binding]; other site 1295826001342 membrane-bound complex binding site; other site 1295826001343 hinge residues; other site 1295826001344 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 1295826001345 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 1295826001346 metal binding site [ion binding]; metal-binding site 1295826001347 dimer interface [polypeptide binding]; other site 1295826001348 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1295826001349 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK06079 1295826001350 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 1295826001351 NAD binding site [chemical binding]; other site 1295826001352 homotetramer interface [polypeptide binding]; other site 1295826001353 homodimer interface [polypeptide binding]; other site 1295826001354 substrate binding site [chemical binding]; other site 1295826001355 active site 1295826001356 OxaA-like protein precursor; Provisional; Region: PRK02463 1295826001357 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 1295826001358 Eukaryotic phosphomannomutase; Region: PMM; cl17107 1295826001359 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 1295826001360 Predicted membrane protein [Function unknown]; Region: COG4684 1295826001361 phosphopantothenoylcysteine decarboxylase, streptococcal; Region: coaC_strep; TIGR02113 1295826001362 Flavoprotein; Region: Flavoprotein; pfam02441 1295826001363 phosphopantothenate--cysteine ligase; Validated; Region: PRK06732 1295826001364 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 1295826001365 active site 1 [active] 1295826001366 dimer interface [polypeptide binding]; other site 1295826001367 hexamer interface [polypeptide binding]; other site 1295826001368 active site 2 [active] 1295826001369 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1295826001370 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 1295826001371 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1295826001372 motif II; other site 1295826001373 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1295826001374 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1295826001375 Coenzyme A binding pocket [chemical binding]; other site 1295826001376 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1295826001377 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1295826001378 active site 1295826001379 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1295826001380 thymidine kinase; Provisional; Region: PRK04296 1295826001381 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1295826001382 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1295826001383 RF-1 domain; Region: RF-1; pfam00472 1295826001384 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 1295826001385 dimer interface [polypeptide binding]; other site 1295826001386 FMN binding site [chemical binding]; other site 1295826001387 NADPH bind site [chemical binding]; other site 1295826001388 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1295826001389 Lysozyme-like; Region: Lysozyme_like; pfam13702 1295826001390 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1295826001391 3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355 1295826001392 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1295826001393 catalytic residue [active] 1295826001394 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_3; cd12174 1295826001395 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 1295826001396 putative ligand binding site [chemical binding]; other site 1295826001397 putative NAD binding site [chemical binding]; other site 1295826001398 putative catalytic site [active] 1295826001399 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1295826001400 phosphoserine phosphatase SerB; Region: serB; TIGR00338 1295826001401 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1295826001402 motif II; other site 1295826001403 acylphosphatase; Provisional; Region: PRK14434 1295826001404 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1295826001405 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1295826001406 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1295826001407 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cl00217 1295826001408 dimer interface [polypeptide binding]; other site 1295826001409 flavodoxin; Validated; Region: PRK07308 1295826001410 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1295826001411 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1295826001412 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 1295826001413 Predicted membrane protein [Function unknown]; Region: COG2246 1295826001414 GtrA-like protein; Region: GtrA; pfam04138 1295826001415 Protein of unknown function (DUF1294); Region: DUF1294; cl01311 1295826001416 HPr kinase/phosphorylase; Provisional; Region: PRK05428 1295826001417 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 1295826001418 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 1295826001419 Hpr binding site; other site 1295826001420 active site 1295826001421 homohexamer subunit interaction site [polypeptide binding]; other site 1295826001422 Prolipoprotein diacylglyceryl transferase; Region: LGT; pfam01790 1295826001423 Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768 1295826001424 YtxH-like protein; Region: YtxH; cl02079 1295826001425 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1295826001426 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 1295826001427 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 1295826001428 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1295826001429 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1295826001430 ATP binding site [chemical binding]; other site 1295826001431 putative Mg++ binding site [ion binding]; other site 1295826001432 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 1295826001433 K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158 1295826001434 K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158 1295826001435 Protein of unknown function (DUF3042); Region: DUF3042; pfam11240 1295826001436 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1295826001437 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1295826001438 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1295826001439 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1295826001440 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_4; cd03407 1295826001441 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1295826001442 non-specific DNA binding site [nucleotide binding]; other site 1295826001443 salt bridge; other site 1295826001444 sequence-specific DNA binding site [nucleotide binding]; other site 1295826001445 Lactococcus bacteriophage repressor; Region: Lac_bphage_repr; pfam06543 1295826001446 ribonuclease Z; Region: RNase_Z; TIGR02651 1295826001447 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1295826001448 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1295826001449 NAD(P) binding site [chemical binding]; other site 1295826001450 active site 1295826001451 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 1295826001452 DHH family; Region: DHH; pfam01368 1295826001453 DHHA1 domain; Region: DHHA1; pfam02272 1295826001454 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4199 1295826001455 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1295826001456 active site 1295826001457 Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559 1295826001458 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 1295826001459 dimerization interface [polypeptide binding]; other site 1295826001460 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1295826001461 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1295826001462 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1295826001463 Transcriptional repressor of class III stress genes [Transcription]; Region: CtsR; COG4463 1295826001464 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 1295826001465 Clp amino terminal domain; Region: Clp_N; pfam02861 1295826001466 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1295826001467 Walker A motif; other site 1295826001468 ATP binding site [chemical binding]; other site 1295826001469 Walker B motif; other site 1295826001470 arginine finger; other site 1295826001471 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1295826001472 Walker A motif; other site 1295826001473 ATP binding site [chemical binding]; other site 1295826001474 Walker B motif; other site 1295826001475 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1295826001476 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1295826001477 30S subunit binding site; other site 1295826001478 enolase; Provisional; Region: eno; PRK00077 1295826001479 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1295826001480 dimer interface [polypeptide binding]; other site 1295826001481 metal binding site [ion binding]; metal-binding site 1295826001482 substrate binding pocket [chemical binding]; other site 1295826001483 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1295826001484 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1295826001485 Walker A/P-loop; other site 1295826001486 ATP binding site [chemical binding]; other site 1295826001487 Q-loop/lid; other site 1295826001488 ABC transporter signature motif; other site 1295826001489 Walker B; other site 1295826001490 D-loop; other site 1295826001491 H-loop/switch region; other site 1295826001492 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1295826001493 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1295826001494 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1295826001495 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 1295826001496 Pyruvate formate lyase 1; Region: PFL1; cd01678 1295826001497 coenzyme A binding site [chemical binding]; other site 1295826001498 active site 1295826001499 catalytic residues [active] 1295826001500 glycine loop; other site 1295826001501 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 1295826001502 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1295826001503 CoA-binding site [chemical binding]; other site 1295826001504 ATP-binding [chemical binding]; other site 1295826001505 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1295826001506 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 1295826001507 pyruvate carboxylase; Reviewed; Region: PRK12999 1295826001508 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1295826001509 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1295826001510 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1295826001511 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 1295826001512 active site 1295826001513 catalytic residues [active] 1295826001514 metal binding site [ion binding]; metal-binding site 1295826001515 homodimer binding site [polypeptide binding]; other site 1295826001516 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1295826001517 carboxyltransferase (CT) interaction site; other site 1295826001518 biotinylation site [posttranslational modification]; other site 1295826001519 Isocitrate dehydrogenases [Energy production and conversion]; Region: Icd; COG0538 1295826001520 isocitrate dehydrogenase; Validated; Region: PRK07362 1295826001521 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 1295826001522 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1295826001523 oligomer interface [polypeptide binding]; other site 1295826001524 active site residues [active] 1295826001525 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 1295826001526 ArsC family; Region: ArsC; pfam03960 1295826001527 putative catalytic residues [active] 1295826001528 thiol/disulfide switch; other site 1295826001529 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1295826001530 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 1295826001531 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1295826001532 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1295826001533 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1295826001534 motif II; other site 1295826001535 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1295826001536 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 1295826001537 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1295826001538 poly-beta-1,6 N-acetyl-D-glucosamine synthase; Region: PgaC_IcaA; TIGR03937 1295826001539 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 1295826001540 DXD motif; other site 1295826001541 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 1295826001542 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 1295826001543 Predicted acetyltransferase [General function prediction only]; Region: COG2388 1295826001544 Uncharacterized conserved protein [Function unknown]; Region: COG3592 1295826001545 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1295826001546 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 1295826001547 active site 1295826001548 topology modulation protein; Reviewed; Region: PRK08118 1295826001549 AAA domain; Region: AAA_17; pfam13207 1295826001550 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 1295826001551 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 1295826001552 putative active site [active] 1295826001553 putative metal binding site [ion binding]; other site 1295826001554 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 1295826001555 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1295826001556 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1295826001557 S-adenosylmethionine binding site [chemical binding]; other site 1295826001558 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1295826001559 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1295826001560 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1295826001561 active site 1295826001562 elongation factor P; Validated; Region: PRK00529 1295826001563 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1295826001564 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1295826001565 RNA binding site [nucleotide binding]; other site 1295826001566 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1295826001567 RNA binding site [nucleotide binding]; other site 1295826001568 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 1295826001569 Transcription termination factor [Transcription]; Region: NusB; COG0781 1295826001570 4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711 1295826001571 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 1295826001572 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 1295826001573 ligand binding site; other site 1295826001574 oligomer interface; other site 1295826001575 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 1295826001576 dimer interface [polypeptide binding]; other site 1295826001577 N-terminal domain interface [polypeptide binding]; other site 1295826001578 sulfate 1 binding site; other site 1295826001579 glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092 1295826001580 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 1295826001581 ligand binding site; other site 1295826001582 oligomer interface; other site 1295826001583 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 1295826001584 dimer interface [polypeptide binding]; other site 1295826001585 N-terminal domain interface [polypeptide binding]; other site 1295826001586 sulfate 1 binding site; other site 1295826001587 glycogen synthase; Provisional; Region: glgA; PRK00654 1295826001588 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 1295826001589 ADP-binding pocket [chemical binding]; other site 1295826001590 homodimer interface [polypeptide binding]; other site 1295826001591 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 1295826001592 homodimer interface [polypeptide binding]; other site 1295826001593 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 1295826001594 active site pocket [active] 1295826001595 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 1295826001596 active site 1295826001597 homodimer interface [polypeptide binding]; other site 1295826001598 catalytic site [active] 1295826001599 COMC family; Region: ComC; pfam03047 1295826001600 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1295826001601 non-specific DNA binding site [nucleotide binding]; other site 1295826001602 salt bridge; other site 1295826001603 sequence-specific DNA binding site [nucleotide binding]; other site 1295826001604 CAAX protease self-immunity; Region: Abi; pfam02517 1295826001605 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 1295826001606 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1295826001607 putative substrate translocation pore; other site 1295826001608 POT family; Region: PTR2; pfam00854 1295826001609 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 1295826001610 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1295826001611 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1295826001612 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1295826001613 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 1295826001614 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1295826001615 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1295826001616 Walker A/P-loop; other site 1295826001617 ATP binding site [chemical binding]; other site 1295826001618 Q-loop/lid; other site 1295826001619 ABC transporter signature motif; other site 1295826001620 Walker B; other site 1295826001621 D-loop; other site 1295826001622 H-loop/switch region; other site 1295826001623 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1295826001624 putative DNA binding site [nucleotide binding]; other site 1295826001625 putative Zn2+ binding site [ion binding]; other site 1295826001626 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 1295826001627 Flavodoxin domain; Region: Flavodoxin_5; cl17428 1295826001628 NnaC (CMP-NeuNAc synthetase) _like subfamily of SGNH_hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: NnaC_like; cd01841 1295826001629 active site 1295826001630 catalytic triad [active] 1295826001631 oxyanion hole [active] 1295826001632 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1295826001633 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1295826001634 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1295826001635 Walker A/P-loop; other site 1295826001636 ATP binding site [chemical binding]; other site 1295826001637 Q-loop/lid; other site 1295826001638 ABC transporter signature motif; other site 1295826001639 Walker B; other site 1295826001640 D-loop; other site 1295826001641 H-loop/switch region; other site 1295826001642 Predicted integral membrane protein [Function unknown]; Region: COG3548 1295826001643 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1295826001644 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1295826001645 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1295826001646 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1295826001647 Walker A/P-loop; other site 1295826001648 ATP binding site [chemical binding]; other site 1295826001649 Q-loop/lid; other site 1295826001650 ABC transporter signature motif; other site 1295826001651 Walker B; other site 1295826001652 D-loop; other site 1295826001653 H-loop/switch region; other site 1295826001654 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1295826001655 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 1295826001656 FtsX-like permease family; Region: FtsX; pfam02687 1295826001657 Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082); Region: DUF2082; pfam09855 1295826001658 Predicted membrane protein [Function unknown]; Region: COG3619 1295826001659 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 1295826001660 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 1295826001661 putative NAD(P) binding site [chemical binding]; other site 1295826001662 dimer interface [polypeptide binding]; other site 1295826001663 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1295826001664 DNA-binding site [nucleotide binding]; DNA binding site 1295826001665 RNA-binding motif; other site 1295826001666 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1295826001667 DNA-binding site [nucleotide binding]; DNA binding site 1295826001668 RNA-binding motif; other site 1295826001669 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1295826001670 nucleoside/Zn binding site; other site 1295826001671 dimer interface [polypeptide binding]; other site 1295826001672 catalytic motif [active] 1295826001673 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1295826001674 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1295826001675 dimer interface [polypeptide binding]; other site 1295826001676 conserved gate region; other site 1295826001677 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1295826001678 ABC-ATPase subunit interface; other site 1295826001679 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1295826001680 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1295826001681 dimer interface [polypeptide binding]; other site 1295826001682 conserved gate region; other site 1295826001683 ABC-ATPase subunit interface; other site 1295826001684 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1295826001685 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1295826001686 Protein of unknown function, DUF624; Region: DUF624; pfam04854 1295826001687 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 1295826001688 This family represents an uncharacterized glycosyl hydrolase family 31 (GH31) enzyme found in bacteria and eukaryotes that is related to the XylS xylosidase of Sulfolobus solfataricus. Alpha-xylosidases catalyze the release of an alpha-xylose residue...; Region: GH31_xylosidase_XylS-like; cd06595 1295826001689 putative active site [active] 1295826001690 putative catalytic site [active] 1295826001691 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1295826001692 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1295826001693 DNA binding site [nucleotide binding] 1295826001694 domain linker motif; other site 1295826001695 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1295826001696 dimerization interface [polypeptide binding]; other site 1295826001697 ligand binding site [chemical binding]; other site 1295826001698 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1295826001699 CoenzymeA binding site [chemical binding]; other site 1295826001700 subunit interaction site [polypeptide binding]; other site 1295826001701 PHB binding site; other site 1295826001702 N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317 1295826001703 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 1295826001704 active site 1295826001705 octamer interface [polypeptide binding]; other site 1295826001706 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 1295826001707 O-succinylbenzoate-CoA ligase; Region: menE; TIGR01923 1295826001708 acyl-activating enzyme (AAE) consensus motif; other site 1295826001709 putative AMP binding site [chemical binding]; other site 1295826001710 putative active site [active] 1295826001711 putative CoA binding site [chemical binding]; other site 1295826001712 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1295826001713 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1295826001714 substrate binding site [chemical binding]; other site 1295826001715 oxyanion hole (OAH) forming residues; other site 1295826001716 trimer interface [polypeptide binding]; other site 1295826001717 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 1295826001718 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1295826001719 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase [Coenzyme metabolism]; Region: MenD; COG1165 1295826001720 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 1295826001721 dimer interface [polypeptide binding]; other site 1295826001722 tetramer interface [polypeptide binding]; other site 1295826001723 PYR/PP interface [polypeptide binding]; other site 1295826001724 TPP binding site [chemical binding]; other site 1295826001725 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 1295826001726 TPP-binding site; other site 1295826001727 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 1295826001728 chorismate binding enzyme; Region: Chorismate_bind; cl10555 1295826001729 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1295826001730 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1295826001731 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 1295826001732 DRTGG domain; Region: DRTGG; pfam07085 1295826001733 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 1295826001734 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 1295826001735 DHH family; Region: DHH; pfam01368 1295826001736 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 1295826001737 active site 1295826001738 homotetramer interface [polypeptide binding]; other site 1295826001739 homodimer interface [polypeptide binding]; other site 1295826001740 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1295826001741 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1295826001742 active site 1295826001743 motif I; other site 1295826001744 motif II; other site 1295826001745 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1295826001746 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4696 1295826001747 metal binding site [ion binding]; metal-binding site 1295826001748 aspartate kinase; Reviewed; Region: PRK09034 1295826001749 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 1295826001750 nucleotide binding site [chemical binding]; other site 1295826001751 substrate binding site [chemical binding]; other site 1295826001752 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 1295826001753 allosteric regulatory residue; other site 1295826001754 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 1295826001755 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1295826001756 MarR family; Region: MarR_2; pfam12802 1295826001757 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 1295826001758 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1295826001759 motif II; other site 1295826001760 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 1295826001761 DHH family; Region: DHH; pfam01368 1295826001762 DHHA1 domain; Region: DHHA1; pfam02272 1295826001763 replicative DNA helicase; Provisional; Region: PRK05748 1295826001764 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1295826001765 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1295826001766 Walker A motif; other site 1295826001767 ATP binding site [chemical binding]; other site 1295826001768 Walker B motif; other site 1295826001769 DNA binding loops [nucleotide binding] 1295826001770 Uncharacterized protein conserved in bacteria [Function unknown]; Region: Veg; COG4466 1295826001771 Phosphotransferase enzyme family; Region: APH; pfam01636 1295826001772 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1295826001773 active site 1295826001774 ATP binding site [chemical binding]; other site 1295826001775 substrate binding site [chemical binding]; other site 1295826001776 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1295826001777 S-adenosylmethionine binding site [chemical binding]; other site 1295826001778 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 1295826001779 Transcription factor S-II (TFIIS); Region: TFIIS_C; cl02609 1295826001780 ATP cone domain; Region: ATP-cone; pfam03477 1295826001781 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 1295826001782 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 1295826001783 primosomal protein DnaI; Reviewed; Region: PRK08939 1295826001784 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 1295826001785 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1295826001786 Walker A motif; other site 1295826001787 ATP binding site [chemical binding]; other site 1295826001788 Walker B motif; other site 1295826001789 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 1295826001790 dimer interface [polypeptide binding]; other site 1295826001791 FMN binding site [chemical binding]; other site 1295826001792 NADPH bind site [chemical binding]; other site 1295826001793 GTP-binding protein Der; Reviewed; Region: PRK00093 1295826001794 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1295826001795 G1 box; other site 1295826001796 GTP/Mg2+ binding site [chemical binding]; other site 1295826001797 Switch I region; other site 1295826001798 G2 box; other site 1295826001799 Switch II region; other site 1295826001800 G3 box; other site 1295826001801 G4 box; other site 1295826001802 G5 box; other site 1295826001803 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1295826001804 G1 box; other site 1295826001805 GTP/Mg2+ binding site [chemical binding]; other site 1295826001806 Switch I region; other site 1295826001807 G2 box; other site 1295826001808 G3 box; other site 1295826001809 Switch II region; other site 1295826001810 G4 box; other site 1295826001811 G5 box; other site 1295826001812 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1295826001813 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1295826001814 non-specific DNA binding site [nucleotide binding]; other site 1295826001815 salt bridge; other site 1295826001816 sequence-specific DNA binding site [nucleotide binding]; other site 1295826001817 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 1295826001818 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 1295826001819 CD20-like family; Region: CD20; pfam04103 1295826001820 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 1295826001821 active site 1295826001822 catalytic site [active] 1295826001823 Protein of unknown function (DUF3990); Region: DUF3990; pfam13151 1295826001824 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 1295826001825 Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380 1295826001826 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG0779 1295826001827 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 1295826001828 putative oligomer interface [polypeptide binding]; other site 1295826001829 putative RNA binding site [nucleotide binding]; other site 1295826001830 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 1295826001831 NusA N-terminal domain; Region: NusA_N; pfam08529 1295826001832 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1295826001833 RNA binding site [nucleotide binding]; other site 1295826001834 homodimer interface [polypeptide binding]; other site 1295826001835 NusA-like KH domain; Region: KH_5; pfam13184 1295826001836 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1295826001837 G-X-X-G motif; other site 1295826001838 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 1295826001839 putative RNA binding cleft [nucleotide binding]; other site 1295826001840 hypothetical protein; Provisional; Region: PRK07283 1295826001841 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1295826001842 translation initiation factor IF-2; Region: IF-2; TIGR00487 1295826001843 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1295826001844 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1295826001845 G1 box; other site 1295826001846 putative GEF interaction site [polypeptide binding]; other site 1295826001847 GTP/Mg2+ binding site [chemical binding]; other site 1295826001848 Switch I region; other site 1295826001849 G2 box; other site 1295826001850 G3 box; other site 1295826001851 Switch II region; other site 1295826001852 G4 box; other site 1295826001853 G5 box; other site 1295826001854 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1295826001855 Translation-initiation factor 2; Region: IF-2; pfam11987 1295826001856 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1295826001857 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1295826001858 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 1295826001859 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 1295826001860 MarR family; Region: MarR; pfam01047 1295826001861 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 1295826001862 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1295826001863 dimer interface [polypeptide binding]; other site 1295826001864 active site 1295826001865 CoA binding pocket [chemical binding]; other site 1295826001866 acyl carrier protein; Provisional; Region: acpP; PRK00982 1295826001867 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1295826001868 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1295826001869 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1295826001870 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 1295826001871 NAD(P) binding site [chemical binding]; other site 1295826001872 homotetramer interface [polypeptide binding]; other site 1295826001873 homodimer interface [polypeptide binding]; other site 1295826001874 active site 1295826001875 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 1295826001876 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1295826001877 dimer interface [polypeptide binding]; other site 1295826001878 active site 1295826001879 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 1295826001880 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1295826001881 carboxyltransferase (CT) interaction site; other site 1295826001882 biotinylation site [posttranslational modification]; other site 1295826001883 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1295826001884 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1295826001885 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1295826001886 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1295826001887 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1295826001888 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 1295826001889 DNA directed RNA polymerase, 7 kDa subunit; Region: DNA_RNApol_7kD; cl00874 1295826001890 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1295826001891 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; COG0825 1295826001892 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1295826001893 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1295826001894 dimer interface [polypeptide binding]; other site 1295826001895 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1295826001896 catalytic residue [active] 1295826001897 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237 1295826001898 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1295826001899 active site residue [active] 1295826001900 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1295826001901 active site residue [active] 1295826001902 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1295826001903 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 1295826001904 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1295826001905 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1295826001906 Member of the Rhodanese Homology Domain superfamily. Included in this CD are the Lactococcus lactis NADH oxidase, Bacillus cereus NADH dehydrogenase, and Bacteroides thetaiotaomicron pyridine nucleotide-disulphide oxidoreductase, and similar...; Region: RHOD_Pyr_redox; cd01524 1295826001907 active site residue [active] 1295826001908 Uncharacterized protein YrkD from Bacillus subtilis and related domains; this domain superfamily was previously known as part of DUF156; Region: BsYrkD-like_DUF156; cd10155 1295826001909 putative homodimer interface [polypeptide binding]; other site 1295826001910 putative homotetramer interface [polypeptide binding]; other site 1295826001911 putative metal binding site [ion binding]; other site 1295826001912 putative homodimer-homodimer interface [polypeptide binding]; other site 1295826001913 putative allosteric switch controlling residues; other site 1295826001914 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1295826001915 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1295826001916 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1295826001917 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1295826001918 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 1295826001919 active site 1295826001920 putative catalytic site [active] 1295826001921 DNA binding site [nucleotide binding] 1295826001922 putative phosphate binding site [ion binding]; other site 1295826001923 metal binding site A [ion binding]; metal-binding site 1295826001924 AP binding site [nucleotide binding]; other site 1295826001925 metal binding site B [ion binding]; metal-binding site 1295826001926 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 1295826001927 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1295826001928 active site 1295826001929 HIGH motif; other site 1295826001930 KMSKS motif; other site 1295826001931 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1295826001932 tRNA binding surface [nucleotide binding]; other site 1295826001933 anticodon binding site; other site 1295826001934 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 1295826001935 dimer interface [polypeptide binding]; other site 1295826001936 putative tRNA-binding site [nucleotide binding]; other site 1295826001937 Protein of unknown function (DUF2829); Region: DUF2829; pfam11195 1295826001938 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK06550 1295826001939 classical (c) SDRs; Region: SDR_c; cd05233 1295826001940 NAD(P) binding site [chemical binding]; other site 1295826001941 active site 1295826001942 Predicted membrane protein [Function unknown]; Region: COG4708 1295826001943 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 1295826001944 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1295826001945 NAD binding site [chemical binding]; other site 1295826001946 substrate binding site [chemical binding]; other site 1295826001947 putative active site [active] 1295826001948 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 1295826001949 heterotetramer interface [polypeptide binding]; other site 1295826001950 active site pocket [active] 1295826001951 cleavage site 1295826001952 acetylornithine aminotransferase; Provisional; Region: argD; PRK02936 1295826001953 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1295826001954 inhibitor-cofactor binding pocket; inhibition site 1295826001955 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1295826001956 catalytic residue [active] 1295826001957 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 1295826001958 feedback inhibition sensing region; other site 1295826001959 homohexameric interface [polypeptide binding]; other site 1295826001960 nucleotide binding site [chemical binding]; other site 1295826001961 N-acetyl-L-glutamate binding site [chemical binding]; other site 1295826001962 ornithine carbamoyltransferase; Validated; Region: PRK02102 1295826001963 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1295826001964 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1295826001965 DivIVA domain; Region: DivI1A_domain; TIGR03544 1295826001966 ribonuclease III; Reviewed; Region: rnc; PRK00102 1295826001967 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1295826001968 dimerization interface [polypeptide binding]; other site 1295826001969 active site 1295826001970 metal binding site [ion binding]; metal-binding site 1295826001971 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1295826001972 dsRNA binding site [nucleotide binding]; other site 1295826001973 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1295826001974 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1295826001975 Walker A/P-loop; other site 1295826001976 ATP binding site [chemical binding]; other site 1295826001977 Q-loop/lid; other site 1295826001978 Adenylate cyclase associated (CAP) N terminal; Region: CAP_N; pfam01213 1295826001979 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 1295826001980 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 1295826001981 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1295826001982 Q-loop/lid; other site 1295826001983 ABC transporter signature motif; other site 1295826001984 Walker B; other site 1295826001985 D-loop; other site 1295826001986 H-loop/switch region; other site 1295826001987 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1295826001988 Sulfatase; Region: Sulfatase; cl17466 1295826001989 Predicted multitransmembrane protein [Function unknown]; Region: COG5438 1295826001990 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1295826001991 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1295826001992 active site 1295826001993 motif I; other site 1295826001994 motif II; other site 1295826001995 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1295826001996 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 1295826001997 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 1295826001998 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 1295826001999 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1295826002000 P loop; other site 1295826002001 GTP binding site [chemical binding]; other site 1295826002002 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1295826002003 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1295826002004 HIGH motif; other site 1295826002005 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1295826002006 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1295826002007 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1295826002008 active site 1295826002009 KMSKS motif; other site 1295826002010 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1295826002011 tRNA binding surface [nucleotide binding]; other site 1295826002012 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1295826002013 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1295826002014 beta-galactosidase; Region: BGL; TIGR03356 1295826002015 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1295826002016 Lipase (class 2); Region: Lipase_2; pfam01674 1295826002017 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 1295826002018 nucleophilic elbow; other site 1295826002019 catalytic triad; other site 1295826002020 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1295826002021 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1295826002022 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1295826002023 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1295826002024 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 1295826002025 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1295826002026 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 1295826002027 putative L-serine binding site [chemical binding]; other site 1295826002028 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 1295826002029 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 1295826002030 Predicted transcriptional regulator [Transcription]; Region: COG3682 1295826002031 copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698 1295826002032 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1295826002033 metal-binding site [ion binding] 1295826002034 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1295826002035 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1295826002036 metal-binding site [ion binding] 1295826002037 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1295826002038 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 1295826002039 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 1295826002040 nucleotide binding site/active site [active] 1295826002041 HIT family signature motif; other site 1295826002042 catalytic residue [active] 1295826002043 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 1295826002044 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1295826002045 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 1295826002046 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1295826002047 RNA binding site [nucleotide binding]; other site 1295826002048 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1295826002049 RNA binding site [nucleotide binding]; other site 1295826002050 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 1295826002051 RNA binding site [nucleotide binding]; other site 1295826002052 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1295826002053 RNA binding site [nucleotide binding]; other site 1295826002054 Fibronectin-binding repeat; Region: SSURE; pfam11966 1295826002055 Fibronectin-binding repeat; Region: SSURE; pfam11966 1295826002056 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 1295826002057 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 1295826002058 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 1295826002059 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1295826002060 minor groove reading motif; other site 1295826002061 helix-hairpin-helix signature motif; other site 1295826002062 substrate binding pocket [chemical binding]; other site 1295826002063 active site 1295826002064 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 1295826002065 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 1295826002066 DNA binding and oxoG recognition site [nucleotide binding] 1295826002067 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1295826002068 sequence-specific DNA binding site [nucleotide binding]; other site 1295826002069 salt bridge; other site 1295826002070 beta-1,6-galactofuranosyltransferase; Provisional; Region: PRK09814 1295826002071 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1295826002072 accessory Sec system glycosylation protein GtfA; Region: TIGR02918 1295826002073 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 1295826002074 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK12417 1295826002075 SecY translocase; Region: SecY; pfam00344 1295826002076 accessory Sec system protein Asp3; Region: acc_sec_asp3; TIGR03711 1295826002077 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 1295826002078 Mga helix-turn-helix domain; Region: Mga; pfam05043 1295826002079 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1295826002080 active site 1295826002081 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 1295826002082 trimer interface [polypeptide binding]; other site 1295826002083 active site 1295826002084 substrate binding site [chemical binding]; other site 1295826002085 CoA binding site [chemical binding]; other site 1295826002086 Lipopolysaccharide biosynthesis proteins, LPS:glycosyltransferases [Cell envelope biogenesis, outer membrane]; Region: RfaJ; COG1442 1295826002087 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 1295826002088 Ligand binding site; other site 1295826002089 metal-binding site 1295826002090 glycosyltransferase, SP_1767 family; Region: glyco_access_1; TIGR03728 1295826002091 dipeptidase PepV; Region: dipeptidase; TIGR01886 1295826002092 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 1295826002093 active site 1295826002094 metal binding site [ion binding]; metal-binding site 1295826002095 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 1295826002096 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 1295826002097 ArsC family; Region: ArsC; pfam03960 1295826002098 putative catalytic residues [active] 1295826002099 thiol/disulfide switch; other site 1295826002100 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 1295826002101 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1295826002102 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1295826002103 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1295826002104 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1295826002105 Walker A/P-loop; other site 1295826002106 ATP binding site [chemical binding]; other site 1295826002107 Q-loop/lid; other site 1295826002108 ABC transporter signature motif; other site 1295826002109 Walker B; other site 1295826002110 D-loop; other site 1295826002111 H-loop/switch region; other site 1295826002112 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1295826002113 ABC-ATPase subunit interface; other site 1295826002114 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 1295826002115 Rhomboid family; Region: Rhomboid; cl11446 1295826002116 bacteriocin secretion accessory protein; Region: bacteriocin_acc; TIGR01000 1295826002117 HlyD family secretion protein; Region: HlyD_3; pfam13437 1295826002118 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 1295826002119 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418 1295826002120 putative active site [active] 1295826002121 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1295826002122 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1295826002123 Walker A/P-loop; other site 1295826002124 ATP binding site [chemical binding]; other site 1295826002125 Q-loop/lid; other site 1295826002126 ABC transporter signature motif; other site 1295826002127 Walker B; other site 1295826002128 D-loop; other site 1295826002129 H-loop/switch region; other site 1295826002130 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 1295826002131 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1295826002132 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 1295826002133 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14179 1295826002134 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1295826002135 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1295826002136 homodimer interface [polypeptide binding]; other site 1295826002137 NADP binding site [chemical binding]; other site 1295826002138 substrate binding site [chemical binding]; other site 1295826002139 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 1295826002140 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1295826002141 generic binding surface II; other site 1295826002142 generic binding surface I; other site 1295826002143 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 1295826002144 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 1295826002145 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1295826002146 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 1295826002147 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1295826002148 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1295826002149 substrate binding pocket [chemical binding]; other site 1295826002150 chain length determination region; other site 1295826002151 substrate-Mg2+ binding site; other site 1295826002152 catalytic residues [active] 1295826002153 aspartate-rich region 1; other site 1295826002154 active site lid residues [active] 1295826002155 aspartate-rich region 2; other site 1295826002156 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1295826002157 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1295826002158 Coenzyme A binding pocket [chemical binding]; other site 1295826002159 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 1295826002160 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1295826002161 RNA binding surface [nucleotide binding]; other site 1295826002162 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 1295826002163 Arginine repressor [Transcription]; Region: ArgR; COG1438 1295826002164 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1295826002165 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1295826002166 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 1295826002167 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1295826002168 Walker A/P-loop; other site 1295826002169 ATP binding site [chemical binding]; other site 1295826002170 Q-loop/lid; other site 1295826002171 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1295826002172 ABC transporter signature motif; other site 1295826002173 Walker B; other site 1295826002174 D-loop; other site 1295826002175 H-loop/switch region; other site 1295826002176 Predicted integral membrane protein [Function unknown]; Region: COG3548 1295826002177 Predicted membrane protein [Function unknown]; Region: COG3152 1295826002178 Protein of unknown function (DUF805); Region: DUF805; pfam05656 1295826002179 Protein of unknown function (DUF805); Region: DUF805; cl01224 1295826002180 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 1295826002181 MraW methylase family; Region: Methyltransf_5; pfam01795 1295826002182 Protein required for the initiation of cell division [Cell division and chromosome partitioning]; Region: FtsL; COG4839 1295826002183 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1295826002184 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1295826002185 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1295826002186 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 1295826002187 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 1295826002188 phospho-N-acetylmuramoyl-pentapeptide-transferase; Region: mraY; TIGR00445 1295826002189 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1295826002190 Mg++ binding site [ion binding]; other site 1295826002191 putative catalytic motif [active] 1295826002192 putative substrate binding site [chemical binding]; other site 1295826002193 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1295826002194 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1295826002195 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1295826002196 Walker A/P-loop; other site 1295826002197 ATP binding site [chemical binding]; other site 1295826002198 Q-loop/lid; other site 1295826002199 ABC transporter signature motif; other site 1295826002200 Walker B; other site 1295826002201 D-loop; other site 1295826002202 H-loop/switch region; other site 1295826002203 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1295826002204 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1295826002205 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1295826002206 dimerization interface [polypeptide binding]; other site 1295826002207 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1295826002208 synthetase active site [active] 1295826002209 NTP binding site [chemical binding]; other site 1295826002210 metal binding site [ion binding]; metal-binding site 1295826002211 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1295826002212 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 1295826002213 SnoaL-like domain; Region: SnoaL_3; pfam13474 1295826002214 N-glycosyltransferase; Provisional; Region: PRK11204 1295826002215 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 1295826002216 DXD motif; other site 1295826002217 nicotinamide mononucleotide transporter PnuC; Region: NMN_trans_PnuC; TIGR01528 1295826002218 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1295826002219 Ligand Binding Site [chemical binding]; other site 1295826002220 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1295826002221 IHF dimer interface [polypeptide binding]; other site 1295826002222 IHF - DNA interface [nucleotide binding]; other site 1295826002223 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 1295826002224 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1295826002225 Predicted membrane protein [Function unknown]; Region: COG1511 1295826002226 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1295826002227 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 1295826002228 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 1295826002229 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1295826002230 Histidine kinase; Region: HisKA_3; pfam07730 1295826002231 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1295826002232 ATP binding site [chemical binding]; other site 1295826002233 Mg2+ binding site [ion binding]; other site 1295826002234 G-X-G motif; other site 1295826002235 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1295826002236 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1295826002237 active site 1295826002238 phosphorylation site [posttranslational modification] 1295826002239 intermolecular recognition site; other site 1295826002240 dimerization interface [polypeptide binding]; other site 1295826002241 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1295826002242 DNA binding residues [nucleotide binding] 1295826002243 dimerization interface [polypeptide binding]; other site 1295826002244 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1295826002245 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1295826002246 motif II; other site 1295826002247 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1295826002248 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1295826002249 active site 1295826002250 Predicted RNA binding protein (contains ribosomal protein S1 domain) [Translation, ribosomal structure and biogenesis]; Region: VacB; COG1098 1295826002251 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1295826002252 RNA binding site [nucleotide binding]; other site 1295826002253 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1295826002254 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1295826002255 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 1295826002256 acetoin reductase; Validated; Region: PRK08643 1295826002257 meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366 1295826002258 NAD binding site [chemical binding]; other site 1295826002259 homotetramer interface [polypeptide binding]; other site 1295826002260 homodimer interface [polypeptide binding]; other site 1295826002261 active site 1295826002262 substrate binding site [chemical binding]; other site 1295826002263 malate dehydrogenase; Provisional; Region: PRK13529 1295826002264 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1295826002265 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 1295826002266 NAD(P) binding site [chemical binding]; other site 1295826002267 2-hydroxycarboxylate transporter family; Region: 2HCT; cl01386 1295826002268 EamA-like transporter family; Region: EamA; pfam00892 1295826002269 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1295826002270 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1295826002271 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1295826002272 Walker A/P-loop; other site 1295826002273 ATP binding site [chemical binding]; other site 1295826002274 Q-loop/lid; other site 1295826002275 ABC transporter signature motif; other site 1295826002276 Walker B; other site 1295826002277 D-loop; other site 1295826002278 H-loop/switch region; other site 1295826002279 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 1295826002280 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 1295826002281 putative metal binding site [ion binding]; other site 1295826002282 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1295826002283 active site 1295826002284 metal binding site [ion binding]; metal-binding site 1295826002285 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1295826002286 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1295826002287 motif II; other site 1295826002288 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 1295826002289 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1295826002290 Mg2+ binding site [ion binding]; other site 1295826002291 G-X-G motif; other site 1295826002292 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1295826002293 anchoring element; other site 1295826002294 dimer interface [polypeptide binding]; other site 1295826002295 ATP binding site [chemical binding]; other site 1295826002296 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1295826002297 active site 1295826002298 putative metal-binding site [ion binding]; other site 1295826002299 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1295826002300 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1295826002301 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1295826002302 non-specific DNA binding site [nucleotide binding]; other site 1295826002303 salt bridge; other site 1295826002304 sequence-specific DNA binding site [nucleotide binding]; other site 1295826002305 Lactococcus bacteriophage repressor; Region: Lac_bphage_repr; pfam06543 1295826002306 Predicted transcriptional regulators [Transcription]; Region: COG1695 1295826002307 MarR family; Region: MarR_2; pfam12802 1295826002308 MarR family; Region: MarR_2; cl17246 1295826002309 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1295826002310 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1295826002311 putative substrate translocation pore; other site 1295826002312 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1295826002313 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 1295826002314 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 1295826002315 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 1295826002316 Walker A/P-loop; other site 1295826002317 ATP binding site [chemical binding]; other site 1295826002318 Q-loop/lid; other site 1295826002319 ABC transporter signature motif; other site 1295826002320 Walker B; other site 1295826002321 D-loop; other site 1295826002322 H-loop/switch region; other site 1295826002323 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1295826002324 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1295826002325 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1295826002326 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1295826002327 active site 1295826002328 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1295826002329 active site 1295826002330 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1295826002331 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1295826002332 active site 1295826002333 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1295826002334 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1295826002335 NAD(P) binding site [chemical binding]; other site 1295826002336 active site 1295826002337 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 1295826002338 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 1295826002339 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1295826002340 UDP-galactopyranose mutase; Region: GLF; pfam03275 1295826002341 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1295826002342 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 1295826002343 phosphopentomutase; Provisional; Region: PRK05362 1295826002344 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 1295826002345 Putative zinc ribbon domain; Region: Zn_ribbon_2; pfam12674 1295826002346 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 1295826002347 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 1295826002348 hypothetical protein; Provisional; Region: PRK00967 1295826002349 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1295826002350 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1295826002351 substrate binding pocket [chemical binding]; other site 1295826002352 membrane-bound complex binding site; other site 1295826002353 hinge residues; other site 1295826002354 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1295826002355 dimer interface [polypeptide binding]; other site 1295826002356 conserved gate region; other site 1295826002357 putative PBP binding loops; other site 1295826002358 ABC-ATPase subunit interface; other site 1295826002359 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1295826002360 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1295826002361 Walker A/P-loop; other site 1295826002362 ATP binding site [chemical binding]; other site 1295826002363 Q-loop/lid; other site 1295826002364 ABC transporter signature motif; other site 1295826002365 Walker B; other site 1295826002366 D-loop; other site 1295826002367 H-loop/switch region; other site 1295826002368 Protein of unknown function (DUF4059); Region: DUF4059; pfam13268 1295826002369 Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314 1295826002370 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1295826002371 putative catalytic site [active] 1295826002372 putative metal binding site [ion binding]; other site 1295826002373 putative phosphate binding site [ion binding]; other site 1295826002374 1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; COG1575 1295826002375 UbiA prenyltransferase family; Region: UbiA; pfam01040 1295826002376 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 1295826002377 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 1295826002378 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1295826002379 catalytic core [active] 1295826002380 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1295826002381 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 1295826002382 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 1295826002383 Transcriptional regulator of heat shock gene [Transcription]; Region: HrcA; COG1420 1295826002384 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 1295826002385 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 1295826002386 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1295826002387 dimer interface [polypeptide binding]; other site 1295826002388 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1295826002389 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1295826002390 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 1295826002391 nucleotide binding site [chemical binding]; other site 1295826002392 NEF interaction site [polypeptide binding]; other site 1295826002393 SBD interface [polypeptide binding]; other site 1295826002394 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1295826002395 M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669 1295826002396 metal binding site [ion binding]; metal-binding site 1295826002397 dimer interface [polypeptide binding]; other site 1295826002398 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 1295826002399 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1295826002400 active site 1295826002401 phosphorylation site [posttranslational modification] 1295826002402 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1295826002403 active site 1295826002404 P-loop; other site 1295826002405 phosphorylation site [posttranslational modification] 1295826002406 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 1295826002407 Protein of unknown function (DUF805); Region: DUF805; pfam05656 1295826002408 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1295826002409 metal-binding site [ion binding] 1295826002410 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1295826002411 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1295826002412 ligand binding site [chemical binding]; other site 1295826002413 flexible hinge region; other site 1295826002414 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1295826002415 putative switch regulator; other site 1295826002416 non-specific DNA interactions [nucleotide binding]; other site 1295826002417 DNA binding site [nucleotide binding] 1295826002418 sequence specific DNA binding site [nucleotide binding]; other site 1295826002419 putative cAMP binding site [chemical binding]; other site 1295826002420 Predicted P-loop-containing kinase [General function prediction only]; Region: COG1660 1295826002421 AAA domain; Region: AAA_18; pfam13238 1295826002422 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 1295826002423 Family of CofD-like proteins and proteins related to YvcK; Region: CofD_YvcK; cd07044 1295826002424 dimer interface [polypeptide binding]; other site 1295826002425 phosphate binding site [ion binding]; other site 1295826002426 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 1295826002427 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 1295826002428 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1295826002429 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1295826002430 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1295826002431 Walker A/P-loop; other site 1295826002432 ATP binding site [chemical binding]; other site 1295826002433 Q-loop/lid; other site 1295826002434 ABC transporter signature motif; other site 1295826002435 Walker B; other site 1295826002436 D-loop; other site 1295826002437 H-loop/switch region; other site 1295826002438 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 1295826002439 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 1295826002440 hypothetical protein; Provisional; Region: PRK13662 1295826002441 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 1295826002442 putative phosphoesterase; Region: acc_ester; TIGR03729 1295826002443 peptide chain release factor 2; Validated; Region: prfB; PRK00578 1295826002444 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1295826002445 RF-1 domain; Region: RF-1; pfam00472 1295826002446 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 1295826002447 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1295826002448 Walker A/P-loop; other site 1295826002449 ATP binding site [chemical binding]; other site 1295826002450 Q-loop/lid; other site 1295826002451 ABC transporter signature motif; other site 1295826002452 Walker B; other site 1295826002453 D-loop; other site 1295826002454 H-loop/switch region; other site 1295826002455 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 1295826002456 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 1295826002457 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 1295826002458 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1295826002459 dimer interface [polypeptide binding]; other site 1295826002460 putative radical transfer pathway; other site 1295826002461 diiron center [ion binding]; other site 1295826002462 tyrosyl radical; other site 1295826002463 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07306 1295826002464 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 1295826002465 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1295826002466 active site 1295826002467 dimer interface [polypeptide binding]; other site 1295826002468 catalytic residues [active] 1295826002469 effector binding site; other site 1295826002470 R2 peptide binding site; other site 1295826002471 Protein involved in ribonucleotide reduction [Nucleotide transport and metabolism]; Region: NrdI; COG1780 1295826002472 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1295826002473 catalytic residues [active] 1295826002474 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 1295826002475 DNA topoisomerase IV, B subunit, Gram-positive; Region: parE_Gpos; TIGR01058 1295826002476 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1295826002477 Mg2+ binding site [ion binding]; other site 1295826002478 G-X-G motif; other site 1295826002479 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1295826002480 anchoring element; other site 1295826002481 dimer interface [polypeptide binding]; other site 1295826002482 ATP binding site [chemical binding]; other site 1295826002483 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1295826002484 active site 1295826002485 putative metal-binding site [ion binding]; other site 1295826002486 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1295826002487 Isochorismatase family; Region: Isochorismatase; pfam00857 1295826002488 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1295826002489 catalytic triad [active] 1295826002490 conserved cis-peptide bond; other site 1295826002491 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 1295826002492 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1295826002493 active site 1295826002494 catalytic site [active] 1295826002495 substrate binding site [chemical binding]; other site 1295826002496 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1295826002497 Coenzyme A binding pocket [chemical binding]; other site 1295826002498 DNA topoisomerase IV, A subunit, Gram-positive; Region: parC_Gpos; TIGR01061 1295826002499 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1295826002500 CAP-like domain; other site 1295826002501 active site 1295826002502 primary dimer interface [polypeptide binding]; other site 1295826002503 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1295826002504 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 1295826002505 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 1295826002506 oligomer interface [polypeptide binding]; other site 1295826002507 Cl binding site [ion binding]; other site 1295826002508 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 1295826002509 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 1295826002510 catalytic motif [active] 1295826002511 Zn binding site [ion binding]; other site 1295826002512 RibD C-terminal domain; Region: RibD_C; cl17279 1295826002513 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 1295826002514 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 1295826002515 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1295826002516 dimerization interface [polypeptide binding]; other site 1295826002517 active site 1295826002518 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 1295826002519 homopentamer interface [polypeptide binding]; other site 1295826002520 active site 1295826002521 Predicted transcriptional regulator [Transcription]; Region: COG2378 1295826002522 HTH domain; Region: HTH_11; pfam08279 1295826002523 WYL domain; Region: WYL; pfam13280 1295826002524 lipoprotein signal peptidase; Provisional; Region: PRK14797 1295826002525 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 1295826002526 active site 1295826002527 conserved hypothetical integral membrane protein; Region: TIGR03766 1295826002528 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1295826002529 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1295826002530 Ligand binding site; other site 1295826002531 Putative Catalytic site; other site 1295826002532 DXD motif; other site 1295826002533 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1295826002534 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1295826002535 active site 1295826002536 phosphorylation site [posttranslational modification] 1295826002537 intermolecular recognition site; other site 1295826002538 dimerization interface [polypeptide binding]; other site 1295826002539 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1295826002540 DNA binding site [nucleotide binding] 1295826002541 Predicted membrane protein (DUF2127); Region: DUF2127; cl01785 1295826002542 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1295826002543 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1295826002544 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1295826002545 dimer interface [polypeptide binding]; other site 1295826002546 phosphorylation site [posttranslational modification] 1295826002547 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1295826002548 ATP binding site [chemical binding]; other site 1295826002549 Mg2+ binding site [ion binding]; other site 1295826002550 G-X-G motif; other site 1295826002551 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1295826002552 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1295826002553 glutaminase active site [active] 1295826002554 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1295826002555 dimer interface [polypeptide binding]; other site 1295826002556 active site 1295826002557 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1295826002558 dimer interface [polypeptide binding]; other site 1295826002559 active site 1295826002560 hypothetical protein; Reviewed; Region: PRK00024 1295826002561 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 1295826002562 MPN+ (JAMM) motif; other site 1295826002563 Zinc-binding site [ion binding]; other site 1295826002564 AT-rich DNA-binding protein [General function prediction only]; Region: COG2344 1295826002565 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 1295826002566 CoA binding domain; Region: CoA_binding; pfam02629 1295826002567 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 1295826002568 ArsC family; Region: ArsC; pfam03960 1295826002569 putative catalytic residues [active] 1295826002570 thiol/disulfide switch; other site 1295826002571 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1295826002572 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1295826002573 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1295826002574 Walker A/P-loop; other site 1295826002575 ATP binding site [chemical binding]; other site 1295826002576 Q-loop/lid; other site 1295826002577 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1295826002578 ABC transporter signature motif; other site 1295826002579 Walker B; other site 1295826002580 D-loop; other site 1295826002581 ABC transporter; Region: ABC_tran_2; pfam12848 1295826002582 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1295826002583 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1295826002584 active site 1295826002585 MucBP domain; Region: MucBP; pfam06458 1295826002586 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 1295826002587 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 1295826002588 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 1295826002589 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 1295826002590 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 1295826002591 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 1295826002592 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 1295826002593 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 1295826002594 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 1295826002595 active site 1295826002596 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 1295826002597 DnaD and phage-associated domain; Region: DnaD_dom; TIGR01446 1295826002598 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 1295826002599 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1295826002600 minor groove reading motif; other site 1295826002601 helix-hairpin-helix signature motif; other site 1295826002602 substrate binding pocket [chemical binding]; other site 1295826002603 active site 1295826002604 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 1295826002605 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 1295826002606 Family of unknown function (DUF633); Region: DUF633; pfam04816 1295826002607 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1295826002608 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1295826002609 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4918 1295826002610 sugar phosphate phosphatase; Provisional; Region: PRK10513 1295826002611 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1295826002612 active site 1295826002613 motif I; other site 1295826002614 motif II; other site 1295826002615 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1295826002616 Domain of unknown function (DUF1934); Region: DUF1934; pfam09148 1295826002617 Predicted membrane protein [Function unknown]; Region: COG3371 1295826002618 Protein of unknown function (DUF998); Region: DUF998; pfam06197 1295826002619 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 1295826002620 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1295826002621 Predicted ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG2868 1295826002622 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1295826002623 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1295826002624 PhoH-like protein; Region: PhoH; pfam02562 1295826002625 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 1295826002626 nudix motif; other site 1295826002627 metal-binding heat shock protein; Provisional; Region: PRK00016 1295826002628 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 1295826002629 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3575 1295826002630 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 1295826002631 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1295826002632 active site 1295826002633 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 1295826002634 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1295826002635 Uncharacterized conserved protein [Function unknown]; Region: COG1739 1295826002636 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 1295826002637 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 1295826002638 hypothetical protein; Provisional; Region: PRK14013 1295826002639 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1295826002640 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1295826002641 active site 1295826002642 metal binding site [ion binding]; metal-binding site 1295826002643 T5orf172 domain; Region: T5orf172; pfam10544 1295826002644 glycyl-tRNA synthetase subunit alpha; Validated; Region: glyQ; PRK09348 1295826002645 motif 1; other site 1295826002646 dimer interface [polypeptide binding]; other site 1295826002647 active site 1295826002648 motif 2; other site 1295826002649 motif 3; other site 1295826002650 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 1295826002651 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 1295826002652 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1295826002653 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4224 1295826002654 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1295826002655 ClC sycA-like chloride channel proteins. This ClC family presents in bacteria, where it facilitates acid resistance in acidic soil. Mutation of this gene (sycA) in Rhizobium tropici CIAT899 causes serious deficiencies in nodule development, nodulation...; Region: ClC_sycA_like; cd03682 1295826002656 putative Cl- selectivity filter; other site 1295826002657 putative pore gating glutamate residue; other site 1295826002658 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 1295826002659 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1295826002660 active site 1295826002661 (T/H)XGH motif; other site 1295826002662 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 1295826002663 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 1295826002664 active site 1295826002665 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1295826002666 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1295826002667 Coenzyme A binding pocket [chemical binding]; other site 1295826002668 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 1295826002669 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1295826002670 homodimer interface [polypeptide binding]; other site 1295826002671 NAD binding pocket [chemical binding]; other site 1295826002672 ATP binding pocket [chemical binding]; other site 1295826002673 Mg binding site [ion binding]; other site 1295826002674 active-site loop [active] 1295826002675 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1295826002676 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1295826002677 Walker A/P-loop; other site 1295826002678 ATP binding site [chemical binding]; other site 1295826002679 Q-loop/lid; other site 1295826002680 ABC transporter signature motif; other site 1295826002681 Walker B; other site 1295826002682 D-loop; other site 1295826002683 H-loop/switch region; other site 1295826002684 FtsX-like permease family; Region: FtsX; pfam02687 1295826002685 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1295826002686 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1295826002687 FtsX-like permease family; Region: FtsX; pfam02687 1295826002688 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 1295826002689 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1295826002690 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 1295826002691 Alpha-acetolactate decarboxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AlsD; COG3527 1295826002692 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 1295826002693 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1295826002694 NAD(P) binding site [chemical binding]; other site 1295826002695 putative active site [active] 1295826002696 DNA gyrase subunit A; Validated; Region: PRK05560 1295826002697 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1295826002698 CAP-like domain; other site 1295826002699 active site 1295826002700 primary dimer interface [polypeptide binding]; other site 1295826002701 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1295826002702 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1295826002703 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1295826002704 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1295826002705 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1295826002706 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1295826002707 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 1295826002708 ApbE family; Region: ApbE; pfam02424 1295826002709 Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165 1295826002710 active site 1295826002711 catalytic site [active] 1295826002712 Protein of unknown function (DUF998); Region: DUF998; pfam06197 1295826002713 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 1295826002714 Part of AAA domain; Region: AAA_19; pfam13245 1295826002715 Family description; Region: UvrD_C_2; pfam13538 1295826002716 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 1295826002717 putative active site [active] 1295826002718 nucleotide binding site [chemical binding]; other site 1295826002719 nudix motif; other site 1295826002720 putative metal binding site [ion binding]; other site 1295826002721 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 1295826002722 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1295826002723 dimer interface [polypeptide binding]; other site 1295826002724 fumarate reductase flavoprotein subunit; Validated; Region: PRK06481 1295826002725 L-aspartate oxidase; Provisional; Region: PRK06175 1295826002726 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 1295826002727 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 1295826002728 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 1295826002729 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1295826002730 active site 1295826002731 Riboflavin kinase; Region: Flavokinase; smart00904 1295826002732 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 1295826002733 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 1295826002734 dimer interface [polypeptide binding]; other site 1295826002735 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1295826002736 NAD binding site [chemical binding]; other site 1295826002737 substrate binding site [chemical binding]; other site 1295826002738 Uncharacterized conserved protein [Function unknown]; Region: COG3589 1295826002739 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 1295826002740 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 1295826002741 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 1295826002742 putative active site [active] 1295826002743 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1295826002744 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 1295826002745 active site turn [active] 1295826002746 phosphorylation site [posttranslational modification] 1295826002747 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1295826002748 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 1295826002749 HPr interaction site; other site 1295826002750 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1295826002751 active site 1295826002752 phosphorylation site [posttranslational modification] 1295826002753 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1295826002754 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1295826002755 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1295826002756 putative active site [active] 1295826002757 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1295826002758 triosephosphate isomerase; Provisional; Region: PRK14565 1295826002759 substrate binding site [chemical binding]; other site 1295826002760 dimer interface [polypeptide binding]; other site 1295826002761 catalytic triad [active] 1295826002762 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 1295826002763 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 1295826002764 active site 1295826002765 Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969 1295826002766 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1295826002767 Active Sites [active] 1295826002768 Domain of unknown function (DUF3440); Region: DUF3440; pfam11922 1295826002769 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 1295826002770 ParB-like nuclease domain; Region: ParB; smart00470 1295826002771 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 1295826002772 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1295826002773 FeS/SAM binding site; other site 1295826002774 HemN C-terminal domain; Region: HemN_C; pfam06969 1295826002775 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 1295826002776 catalytic motif [active] 1295826002777 Zn binding site [ion binding]; other site 1295826002778 Acyl-ACP thioesterase [Lipid metabolism]; Region: FatA; COG3884 1295826002779 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1295826002780 active site 1295826002781 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1295826002782 active site 2 [active] 1295826002783 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 1295826002784 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1295826002785 active site 1295826002786 motif I; other site 1295826002787 motif II; other site 1295826002788 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1295826002789 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 1295826002790 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1295826002791 active site 1295826002792 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 1295826002793 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1295826002794 active site 1295826002795 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 1295826002796 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1295826002797 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1295826002798 folate binding site [chemical binding]; other site 1295826002799 NADP+ binding site [chemical binding]; other site 1295826002800 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1295826002801 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 1295826002802 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1295826002803 Walker A motif; other site 1295826002804 ATP binding site [chemical binding]; other site 1295826002805 Walker B motif; other site 1295826002806 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1295826002807 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 1295826002808 G1 box; other site 1295826002809 GTP/Mg2+ binding site [chemical binding]; other site 1295826002810 Switch I region; other site 1295826002811 G2 box; other site 1295826002812 G3 box; other site 1295826002813 Switch II region; other site 1295826002814 G4 box; other site 1295826002815 G5 box; other site 1295826002816 Dihydroneopterin aldolase [Coenzyme metabolism]; Region: FolB; COG1539 1295826002817 active site 1295826002818 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1295826002819 catalytic center binding site [active] 1295826002820 ATP binding site [chemical binding]; other site 1295826002821 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 1295826002822 GTP cyclohydrolase I; Provisional; Region: PLN03044 1295826002823 active site 1295826002824 dihydropteroate synthase; Region: DHPS; TIGR01496 1295826002825 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 1295826002826 substrate binding pocket [chemical binding]; other site 1295826002827 dimer interface [polypeptide binding]; other site 1295826002828 inhibitor binding site; inhibition site 1295826002829 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1295826002830 nudix motif; other site 1295826002831 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 1295826002832 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1295826002833 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1295826002834 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 1295826002835 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 1295826002836 Substrate-binding site [chemical binding]; other site 1295826002837 Substrate specificity [chemical binding]; other site 1295826002838 homoserine kinase; Provisional; Region: PRK01212 1295826002839 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1295826002840 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1295826002841 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 1295826002842 FAD binding domain; Region: FAD_binding_4; pfam01565 1295826002843 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1295826002844 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1295826002845 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1295826002846 Walker A/P-loop; other site 1295826002847 ATP binding site [chemical binding]; other site 1295826002848 Q-loop/lid; other site 1295826002849 ABC transporter signature motif; other site 1295826002850 Walker B; other site 1295826002851 D-loop; other site 1295826002852 H-loop/switch region; other site 1295826002853 TOBE domain; Region: TOBE_2; pfam08402 1295826002854 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1295826002855 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1295826002856 dimer interface [polypeptide binding]; other site 1295826002857 conserved gate region; other site 1295826002858 putative PBP binding loops; other site 1295826002859 ABC-ATPase subunit interface; other site 1295826002860 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 1295826002861 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1295826002862 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1295826002863 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1295826002864 putative substrate translocation pore; other site 1295826002865 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 1295826002866 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 1295826002867 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 1295826002868 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 1295826002869 inhibitor binding site; inhibition site 1295826002870 active site 1295826002871 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1295826002872 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1295826002873 non-specific DNA binding site [nucleotide binding]; other site 1295826002874 salt bridge; other site 1295826002875 sequence-specific DNA binding site [nucleotide binding]; other site 1295826002876 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 1295826002877 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 1295826002878 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1295826002879 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 1295826002880 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 1295826002881 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 1295826002882 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 1295826002883 Predicted membrane protein [Function unknown]; Region: COG2364 1295826002884 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1295826002885 NAD binding site [chemical binding]; other site 1295826002886 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1295826002887 DNA-binding site [nucleotide binding]; DNA binding site 1295826002888 RNA-binding motif; other site 1295826002889 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1295826002890 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1295826002891 DNA binding site [nucleotide binding] 1295826002892 domain linker motif; other site 1295826002893 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1295826002894 dimerization interface [polypeptide binding]; other site 1295826002895 ligand binding site [chemical binding]; other site 1295826002896 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1295826002897 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1295826002898 nucleotide binding site [chemical binding]; other site 1295826002899 N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850 1295826002900 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959 1295826002901 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1295826002902 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 1295826002903 active site 1295826002904 motif I; other site 1295826002905 motif II; other site 1295826002906 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1295826002907 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1295826002908 Predicted transcriptional regulators [Transcription]; Region: COG1725 1295826002909 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1295826002910 DNA-binding site [nucleotide binding]; DNA binding site 1295826002911 Predicted transcriptional regulator [Transcription]; Region: COG2378 1295826002912 HTH domain; Region: HTH_11; pfam08279 1295826002913 WYL domain; Region: WYL; pfam13280 1295826002914 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1295826002915 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1295826002916 NAD(P) binding site [chemical binding]; other site 1295826002917 active site 1295826002918 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 1295826002919 non-specific DNA binding site [nucleotide binding]; other site 1295826002920 salt bridge; other site 1295826002921 sequence-specific DNA binding site [nucleotide binding]; other site 1295826002922 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 1295826002923 ArsC family; Region: ArsC; pfam03960 1295826002924 putative catalytic residues [active] 1295826002925 thiol/disulfide switch; other site 1295826002926 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1295826002927 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 1295826002928 DNA binding residues [nucleotide binding] 1295826002929 putative dimer interface [polypeptide binding]; other site 1295826002930 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 1295826002931 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 1295826002932 putative active site cavity [active] 1295826002933 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1295826002934 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1295826002935 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1295826002936 putative active site [active] 1295826002937 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 1295826002938 TRAM domain; Region: TRAM; cl01282 1295826002939 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1295826002940 S-adenosylmethionine binding site [chemical binding]; other site 1295826002941 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 1295826002942 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1295826002943 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1295826002944 S-adenosylmethionine binding site [chemical binding]; other site 1295826002945 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1295826002946 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1295826002947 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1295826002948 binding surface 1295826002949 TPR motif; other site 1295826002950 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1295826002951 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1295826002952 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1295826002953 binding surface 1295826002954 TPR motif; other site 1295826002955 acetolactate synthase; Reviewed; Region: PRK08617 1295826002956 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1295826002957 PYR/PP interface [polypeptide binding]; other site 1295826002958 dimer interface [polypeptide binding]; other site 1295826002959 TPP binding site [chemical binding]; other site 1295826002960 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1295826002961 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1295826002962 TPP-binding site [chemical binding]; other site 1295826002963 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1295826002964 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1295826002965 putative substrate translocation pore; other site 1295826002966 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1295826002967 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1295826002968 non-specific DNA binding site [nucleotide binding]; other site 1295826002969 salt bridge; other site 1295826002970 sequence-specific DNA binding site [nucleotide binding]; other site 1295826002971 legume lectins; Region: lectin_L-type; cl14058 1295826002972 carbohydrate binding site [chemical binding]; other site 1295826002973 metal binding site [ion binding]; metal-binding site 1295826002974 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 1295826002975 domain interaction interfaces [polypeptide binding]; other site 1295826002976 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 1295826002977 domain interaction interfaces [polypeptide binding]; other site 1295826002978 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 1295826002979 domain interaction interfaces [polypeptide binding]; other site 1295826002980 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1295826002981 non-specific DNA binding site [nucleotide binding]; other site 1295826002982 salt bridge; other site 1295826002983 sequence-specific DNA binding site [nucleotide binding]; other site 1295826002984 ribonuclease R; Region: RNase_R; TIGR02063 1295826002985 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 1295826002986 RNB domain; Region: RNB; pfam00773 1295826002987 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 1295826002988 RNA binding site [nucleotide binding]; other site 1295826002989 TspO/MBR family; Region: TspO_MBR; pfam03073 1295826002990 Predicted kinase related to dihydroxyacetone kinase [General function prediction only]; Region: COG1461 1295826002991 DAK2 domain; Region: Dak2; pfam02734 1295826002992 EDD domain protein, DegV family; Region: DegV; TIGR00762 1295826002993 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1295826002994 Steroid 5-alpha reductase family enzyme [General function prediction only]; Region: COG3752 1295826002995 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 1295826002996 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1295826002997 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1295826002998 homodimer interface [polypeptide binding]; other site 1295826002999 catalytic residue [active] 1295826003000 ATP phosphoribosyltransferase, regulatory subunit; Region: hisZ_biosyn_reg; TIGR00443 1295826003001 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1295826003002 dimer interface [polypeptide binding]; other site 1295826003003 motif 1; other site 1295826003004 active site 1295826003005 motif 2; other site 1295826003006 motif 3; other site 1295826003007 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 1295826003008 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 1295826003009 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1295826003010 histidinol dehydrogenase; Region: hisD; TIGR00069 1295826003011 NAD binding site [chemical binding]; other site 1295826003012 dimerization interface [polypeptide binding]; other site 1295826003013 product binding site; other site 1295826003014 substrate binding site [chemical binding]; other site 1295826003015 zinc binding site [ion binding]; other site 1295826003016 catalytic residues [active] 1295826003017 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 1295826003018 putative active site pocket [active] 1295826003019 4-fold oligomerization interface [polypeptide binding]; other site 1295826003020 metal binding residues [ion binding]; metal-binding site 1295826003021 3-fold/trimer interface [polypeptide binding]; other site 1295826003022 Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin...; Region: APH; cd05150 1295826003023 active site 1295826003024 ATP binding site [chemical binding]; other site 1295826003025 Phosphotransferase enzyme family; Region: APH; pfam01636 1295826003026 antibiotic binding site [chemical binding]; other site 1295826003027 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 1295826003028 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1295826003029 putative active site [active] 1295826003030 oxyanion strand; other site 1295826003031 catalytic triad [active] 1295826003032 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1295826003033 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 1295826003034 catalytic residues [active] 1295826003035 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1295826003036 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1295826003037 substrate binding site [chemical binding]; other site 1295826003038 glutamase interaction surface [polypeptide binding]; other site 1295826003039 histidinol phosphate phosphatase, HisJ family; Region: hisJ_fam; TIGR01856 1295826003040 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 1295826003041 active site 1295826003042 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 1295826003043 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 1295826003044 active site residue [active] 1295826003045 Protein of unknown function (DUF3650); Region: DUF3650; pfam12368 1295826003046 2-isopropylmalate synthase; Validated; Region: PRK00915 1295826003047 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 1295826003048 active site 1295826003049 catalytic residues [active] 1295826003050 metal binding site [ion binding]; metal-binding site 1295826003051 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 1295826003052 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 1295826003053 tartrate dehydrogenase; Region: TTC; TIGR02089 1295826003054 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1295826003055 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1295826003056 substrate binding site [chemical binding]; other site 1295826003057 ligand binding site [chemical binding]; other site 1295826003058 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 1295826003059 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1295826003060 substrate binding site [chemical binding]; other site 1295826003061 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1295826003062 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1295826003063 Walker A/P-loop; other site 1295826003064 ATP binding site [chemical binding]; other site 1295826003065 Q-loop/lid; other site 1295826003066 ABC transporter signature motif; other site 1295826003067 Walker B; other site 1295826003068 D-loop; other site 1295826003069 H-loop/switch region; other site 1295826003070 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 1295826003071 ketol-acid reductoisomerase; Provisional; Region: PRK05479 1295826003072 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 1295826003073 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1295826003074 threonine dehydratase; Validated; Region: PRK08639 1295826003075 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1295826003076 tetramer interface [polypeptide binding]; other site 1295826003077 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1295826003078 catalytic residue [active] 1295826003079 C-terminal regulatory domain of Threonine dehydratase; Region: Thr_dehydrat_C; pfam00585 1295826003080 alpha-acetolactate decarboxylase; Region: acetolac_decarb; TIGR01252 1295826003081 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1295826003082 homotrimer interaction site [polypeptide binding]; other site 1295826003083 putative active site [active] 1295826003084 DNA topoisomerase I; Validated; Region: PRK05582 1295826003085 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1295826003086 active site 1295826003087 interdomain interaction site; other site 1295826003088 putative metal-binding site [ion binding]; other site 1295826003089 nucleotide binding site [chemical binding]; other site 1295826003090 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1295826003091 domain I; other site 1295826003092 DNA binding groove [nucleotide binding] 1295826003093 phosphate binding site [ion binding]; other site 1295826003094 domain II; other site 1295826003095 domain III; other site 1295826003096 nucleotide binding site [chemical binding]; other site 1295826003097 catalytic site [active] 1295826003098 domain IV; other site 1295826003099 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1295826003100 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1295826003101 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 1295826003102 Glucose inhibited division protein A; Region: GIDA; pfam01134 1295826003103 site-specific tyrosine recombinase XerS; Reviewed; Region: xerS; PRK05084 1295826003104 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1295826003105 active site 1295826003106 DNA binding site [nucleotide binding] 1295826003107 Int/Topo IB signature motif; other site 1295826003108 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 1295826003109 L-lactate oxidase; Region: L_lactate_ox; TIGR02708 1295826003110 L-Lactate oxidase (LOX) FMN-binding domain. LOX is a member of the family of FMN-containing alpha-hydroxyacid oxidases and catalyzes the oxidation of l-lactate using molecular oxygen to generate pyruvate and H2O2. This family occurs in both prokaryotes...; Region: LOX_like_FMN; cd04737 1295826003111 teramer interface [polypeptide binding]; other site 1295826003112 active site 1295826003113 FMN binding site [chemical binding]; other site 1295826003114 catalytic residues [active] 1295826003115 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 1295826003116 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 1295826003117 potential catalytic triad [active] 1295826003118 conserved cys residue [active] 1295826003119 hypothetical protein; Provisional; Region: PRK14013 1295826003120 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 1295826003121 FAD binding site [chemical binding]; other site 1295826003122 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 1295826003123 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 1295826003124 THF binding site; other site 1295826003125 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1295826003126 substrate binding site [chemical binding]; other site 1295826003127 THF binding site; other site 1295826003128 zinc-binding site [ion binding]; other site 1295826003129 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 1295826003130 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1295826003131 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1295826003132 Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltD; COG3966 1295826003133 DltD N-terminal region; Region: DltD_N; pfam04915 1295826003134 DltD central region; Region: DltD_M; pfam04918 1295826003135 DltD C-terminal region; Region: DltD_C; pfam04914 1295826003136 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 1295826003137 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 1295826003138 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1295826003139 thiamine phosphate binding site [chemical binding]; other site 1295826003140 active site 1295826003141 pyrophosphate binding site [ion binding]; other site 1295826003142 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 1295826003143 substrate binding site [chemical binding]; other site 1295826003144 multimerization interface [polypeptide binding]; other site 1295826003145 ATP binding site [chemical binding]; other site 1295826003146 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1295826003147 N-acetyl-glucosamine transferase is involved in the synthesis of Poly-beta-1,6-N-acetyl-D-glucosamine; Region: GlcNAc-1-P_transferase; cd06436 1295826003148 DXD motif; other site 1295826003149 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 1295826003150 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1295826003151 active site 1295826003152 homodimer interface [polypeptide binding]; other site 1295826003153 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1295826003154 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1295826003155 putative substrate translocation pore; other site 1295826003156 MarR family; Region: MarR_2; pfam12802 1295826003157 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1295826003158 core dimer interface [polypeptide binding]; other site 1295826003159 peripheral dimer interface [polypeptide binding]; other site 1295826003160 L10 interface [polypeptide binding]; other site 1295826003161 L11 interface [polypeptide binding]; other site 1295826003162 putative EF-Tu interaction site [polypeptide binding]; other site 1295826003163 putative EF-G interaction site [polypeptide binding]; other site 1295826003164 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1295826003165 23S rRNA interface [nucleotide binding]; other site 1295826003166 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1295826003167 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1295826003168 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1295826003169 non-specific DNA binding site [nucleotide binding]; other site 1295826003170 salt bridge; other site 1295826003171 sequence-specific DNA binding site [nucleotide binding]; other site 1295826003172 Predicted transcriptional regulator [Transcription]; Region: COG2932 1295826003173 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1295826003174 Catalytic site [active] 1295826003175 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1295826003176 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1295826003177 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1295826003178 Walker A/P-loop; other site 1295826003179 ATP binding site [chemical binding]; other site 1295826003180 Q-loop/lid; other site 1295826003181 ABC transporter signature motif; other site 1295826003182 Walker B; other site 1295826003183 D-loop; other site 1295826003184 H-loop/switch region; other site 1295826003185 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 1295826003186 Predicted membrane protein [Function unknown]; Region: COG3601 1295826003187 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 1295826003188 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1295826003189 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1295826003190 RNA binding surface [nucleotide binding]; other site 1295826003191 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 1295826003192 active site 1295826003193 segregation and condensation protein B; Reviewed; Region: scpB; PRK00135 1295826003194 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 1295826003195 site-specific tyrosine recombinase XerD-like protein; Reviewed; Region: xerD; PRK02436 1295826003196 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495 1295826003197 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1295826003198 active site 1295826003199 catalytic residues [active] 1295826003200 DNA binding site [nucleotide binding] 1295826003201 Int/Topo IB signature motif; other site 1295826003202 FOG: CBS domain [General function prediction only]; Region: COG0517 1295826003203 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 1295826003204 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 1295826003205 active site 1295826003206 metal binding site [ion binding]; metal-binding site 1295826003207 homotetramer interface [polypeptide binding]; other site 1295826003208 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1295826003209 active site 1295826003210 dimerization interface [polypeptide binding]; other site 1295826003211 glutamate racemase; Provisional; Region: PRK00865 1295826003212 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3763 1295826003213 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 1295826003214 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1295826003215 active site 1295826003216 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1295826003217 substrate binding site [chemical binding]; other site 1295826003218 catalytic residues [active] 1295826003219 dimer interface [polypeptide binding]; other site 1295826003220 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 1295826003221 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1295826003222 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 1295826003223 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 1295826003224 active site 1295826003225 dimer interface [polypeptide binding]; other site 1295826003226 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 1295826003227 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1295826003228 active site 1295826003229 FMN binding site [chemical binding]; other site 1295826003230 substrate binding site [chemical binding]; other site 1295826003231 3Fe-4S cluster binding site [ion binding]; other site 1295826003232 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 1295826003233 domain interface; other site 1295826003234 maltose O-acetyltransferase; Provisional; Region: PRK10092 1295826003235 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 1295826003236 active site 1295826003237 substrate binding site [chemical binding]; other site 1295826003238 trimer interface [polypeptide binding]; other site 1295826003239 CoA binding site [chemical binding]; other site 1295826003240 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 1295826003241 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1295826003242 homodimer interface [polypeptide binding]; other site 1295826003243 substrate-cofactor binding pocket; other site 1295826003244 catalytic residue [active] 1295826003245 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 1295826003246 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1295826003247 catalytic residue [active] 1295826003248 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1295826003249 non-specific DNA binding site [nucleotide binding]; other site 1295826003250 salt bridge; other site 1295826003251 sequence-specific DNA binding site [nucleotide binding]; other site 1295826003252 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 1295826003253 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1295826003254 RNA/DNA hybrid binding site [nucleotide binding]; other site 1295826003255 active site 1295826003256 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 1295826003257 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 1295826003258 GTP/Mg2+ binding site [chemical binding]; other site 1295826003259 G4 box; other site 1295826003260 G5 box; other site 1295826003261 G1 box; other site 1295826003262 Switch I region; other site 1295826003263 G2 box; other site 1295826003264 G3 box; other site 1295826003265 Switch II region; other site 1295826003266 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1295826003267 Coenzyme A binding pocket [chemical binding]; other site 1295826003268 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1295826003269 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1295826003270 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1295826003271 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1295826003272 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1295826003273 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 1295826003274 active site 1295826003275 Glycosyl hydrolase family 67 middle domain; Region: Glyco_hydro_67M; pfam07488 1295826003276 Glycosyl hydrolase family 67 C-terminus; Region: Glyco_hydro_67C; pfam07477 1295826003277 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1295826003278 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 1295826003279 NodB motif; other site 1295826003280 active site 1295826003281 catalytic site [active] 1295826003282 metal binding site [ion binding]; metal-binding site 1295826003283 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 1295826003284 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1295826003285 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1295826003286 dimer interface [polypeptide binding]; other site 1295826003287 conserved gate region; other site 1295826003288 putative PBP binding loops; other site 1295826003289 ABC-ATPase subunit interface; other site 1295826003290 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1295826003291 dimer interface [polypeptide binding]; other site 1295826003292 conserved gate region; other site 1295826003293 putative PBP binding loops; other site 1295826003294 ABC-ATPase subunit interface; other site 1295826003295 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1295826003296 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1295826003297 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1295826003298 transmembrane helices; other site 1295826003299 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 1295826003300 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1295826003301 catalytic core [active] 1295826003302 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1295826003303 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1295826003304 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1295826003305 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1295826003306 active site 1295826003307 motif I; other site 1295826003308 motif II; other site 1295826003309 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1295826003310 maltose O-acetyltransferase; Provisional; Region: PRK10092 1295826003311 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 1295826003312 active site 1295826003313 substrate binding site [chemical binding]; other site 1295826003314 trimer interface [polypeptide binding]; other site 1295826003315 CoA binding site [chemical binding]; other site 1295826003316 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1295826003317 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1295826003318 active site 1295826003319 metal binding site [ion binding]; metal-binding site 1295826003320 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1295826003321 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1295826003322 putative substrate translocation pore; other site 1295826003323 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1295826003324 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1295826003325 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 1295826003326 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 1295826003327 dimer interface [polypeptide binding]; other site 1295826003328 PYR/PP interface [polypeptide binding]; other site 1295826003329 TPP binding site [chemical binding]; other site 1295826003330 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1295826003331 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 1295826003332 TPP-binding site [chemical binding]; other site 1295826003333 dimer interface [polypeptide binding]; other site 1295826003334 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1295826003335 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1295826003336 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1295826003337 Protein of unknown function (DUF1498); Region: DUF1498; cl17840 1295826003338 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1295826003339 active site 1295826003340 P-loop; other site 1295826003341 phosphorylation site [posttranslational modification] 1295826003342 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1295826003343 intersubunit interface [polypeptide binding]; other site 1295826003344 active site 1295826003345 zinc binding site [ion binding]; other site 1295826003346 Na+ binding site [ion binding]; other site 1295826003347 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1295826003348 PRD domain; Region: PRD; pfam00874 1295826003349 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1295826003350 active site 1295826003351 P-loop; other site 1295826003352 phosphorylation site [posttranslational modification] 1295826003353 Protein of unknown function (DUF1706); Region: DUF1706; pfam08020 1295826003354 Arsenical resistance operon trans-acting repressor ArsD; Region: ArsD; pfam06953 1295826003355 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1295826003356 ArsC family; Region: ArsC; pfam03960 1295826003357 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 1295826003358 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1295826003359 aminodeoxychorismate synthase, component I, bacterial clade; Region: pabB; TIGR00553 1295826003360 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1295826003361 substrate-cofactor binding pocket; other site 1295826003362 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 1295826003363 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1295826003364 catalytic residue [active] 1295826003365 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 1295826003366 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1295826003367 glutamine binding [chemical binding]; other site 1295826003368 catalytic triad [active] 1295826003369 legume lectins; Region: lectin_L-type; cd01951 1295826003370 homotetramer interaction site [polypeptide binding]; other site 1295826003371 carbohydrate binding site [chemical binding]; other site 1295826003372 metal binding site [ion binding]; metal-binding site 1295826003373 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1295826003374 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 1295826003375 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 1295826003376 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 1295826003377 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 1295826003378 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 1295826003379 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1295826003380 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1295826003381 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1295826003382 DNA-binding site [nucleotide binding]; DNA binding site 1295826003383 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1295826003384 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1295826003385 homodimer interface [polypeptide binding]; other site 1295826003386 catalytic residue [active] 1295826003387 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 1295826003388 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 1295826003389 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1295826003390 non-specific DNA binding site [nucleotide binding]; other site 1295826003391 salt bridge; other site 1295826003392 sequence-specific DNA binding site [nucleotide binding]; other site 1295826003393 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1295826003394 non-specific DNA binding site [nucleotide binding]; other site 1295826003395 salt bridge; other site 1295826003396 sequence-specific DNA binding site [nucleotide binding]; other site 1295826003397 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 1295826003398 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1295826003399 non-specific DNA binding site [nucleotide binding]; other site 1295826003400 salt bridge; other site 1295826003401 sequence-specific DNA binding site [nucleotide binding]; other site 1295826003402 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 1295826003403 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 1295826003404 metal binding site [ion binding]; metal-binding site 1295826003405 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1295826003406 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1295826003407 ABC-ATPase subunit interface; other site 1295826003408 dimer interface [polypeptide binding]; other site 1295826003409 putative PBP binding regions; other site 1295826003410 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1295826003411 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1295826003412 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 1295826003413 Domain of unknown function (DUF4176); Region: DUF4176; cl01867 1295826003414 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 1295826003415 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 1295826003416 Walker A/P-loop; other site 1295826003417 ATP binding site [chemical binding]; other site 1295826003418 Q-loop/lid; other site 1295826003419 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1295826003420 ABC transporter signature motif; other site 1295826003421 Walker B; other site 1295826003422 D-loop; other site 1295826003423 H-loop/switch region; other site 1295826003424 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 1295826003425 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1295826003426 active site 1295826003427 metal binding site [ion binding]; metal-binding site 1295826003428 DNA binding site [nucleotide binding] 1295826003429 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 1295826003430 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 1295826003431 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 1295826003432 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 1295826003433 Domain of unknown function (DUF814); Region: DUF814; pfam05670 1295826003434 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 1295826003435 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1295826003436 Walker A/P-loop; other site 1295826003437 ATP binding site [chemical binding]; other site 1295826003438 Q-loop/lid; other site 1295826003439 ABC transporter signature motif; other site 1295826003440 Walker B; other site 1295826003441 D-loop; other site 1295826003442 H-loop/switch region; other site 1295826003443 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1295826003444 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1295826003445 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1295826003446 TM-ABC transporter signature motif; other site 1295826003447 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 1295826003448 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 1295826003449 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1295826003450 NAD binding site [chemical binding]; other site 1295826003451 dimer interface [polypeptide binding]; other site 1295826003452 substrate binding site [chemical binding]; other site 1295826003453 pyruvate kinase; Provisional; Region: PRK05826 1295826003454 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 1295826003455 domain interfaces; other site 1295826003456 active site 1295826003457 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 1295826003458 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 1295826003459 active site 1295826003460 ADP/pyrophosphate binding site [chemical binding]; other site 1295826003461 dimerization interface [polypeptide binding]; other site 1295826003462 allosteric effector site; other site 1295826003463 fructose-1,6-bisphosphate binding site; other site 1295826003464 Uncharacterized protein involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TelA; COG3853 1295826003465 5-bromo-4-chloroindolyl phosphate hydrolysis protein [General function prediction only]; Region: XpaC; COG4915 1295826003466 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1295826003467 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1295826003468 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1295826003469 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1295826003470 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1295826003471 active site 1295826003472 tetramer interface; other site 1295826003473 Listerrria innocua Lin0431 is similar to the N-Utilization Substance G (NusG) N terminal (NGN) insert (DII); Region: Lin0431_like; cd09911 1295826003474 trimer interface [polypeptide binding]; other site 1295826003475 Predicted membrane protein [Function unknown]; Region: COG4769 1295826003476 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1295826003477 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1295826003478 substrate binding pocket [chemical binding]; other site 1295826003479 chain length determination region; other site 1295826003480 substrate-Mg2+ binding site; other site 1295826003481 catalytic residues [active] 1295826003482 aspartate-rich region 1; other site 1295826003483 active site lid residues [active] 1295826003484 aspartate-rich region 2; other site 1295826003485 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1295826003486 active site 1295826003487 dimer interface [polypeptide binding]; other site 1295826003488 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 1295826003489 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 1295826003490 heterodimer interface [polypeptide binding]; other site 1295826003491 active site 1295826003492 FMN binding site [chemical binding]; other site 1295826003493 homodimer interface [polypeptide binding]; other site 1295826003494 substrate binding site [chemical binding]; other site 1295826003495 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1295826003496 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1295826003497 DNA-binding site [nucleotide binding]; DNA binding site 1295826003498 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1295826003499 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1295826003500 beta-galactosidase; Region: BGL; TIGR03356 1295826003501 short chain dehydrogenase; Provisional; Region: PRK12937 1295826003502 classical (c) SDRs; Region: SDR_c; cd05233 1295826003503 NAD(P) binding site [chemical binding]; other site 1295826003504 active site 1295826003505 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1295826003506 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1295826003507 dimer interface [polypeptide binding]; other site 1295826003508 conserved gate region; other site 1295826003509 ABC-ATPase subunit interface; other site 1295826003510 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1295826003511 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1295826003512 dimer interface [polypeptide binding]; other site 1295826003513 conserved gate region; other site 1295826003514 putative PBP binding loops; other site 1295826003515 ABC-ATPase subunit interface; other site 1295826003516 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1295826003517 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1295826003518 Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448 1295826003519 Membrane protease subunit, stomatin/prohibitin family [Amino acid transport and metabolism]; Region: COG4260 1295826003520 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_5; cd03408 1295826003521 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 1295826003522 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 1295826003523 Repair protein; Region: Repair_PSII; pfam04536 1295826003524 Pseudouridine synthase, Escherichia coli RluE; Region: PseudoU_synth_RluE; cd02566 1295826003525 pseudouridine synthase; Region: TIGR00093 1295826003526 probable active site [active] 1295826003527 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 1295826003528 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1295826003529 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 1295826003530 amphipathic channel; other site 1295826003531 Asn-Pro-Ala signature motifs; other site 1295826003532 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 1295826003533 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 1295826003534 WxL domain surface cell wall-binding; Region: WxL; pfam13731 1295826003535 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 1295826003536 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1295826003537 catalytic residues [active] 1295826003538 dimer interface [polypeptide binding]; other site 1295826003539 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 1295826003540 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 1295826003541 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1295826003542 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1295826003543 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1295826003544 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1295826003545 motif II; other site 1295826003546 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1295826003547 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 1295826003548 TraX protein; Region: TraX; cl05434 1295826003549 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 1295826003550 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1295826003551 Ligand Binding Site [chemical binding]; other site 1295826003552 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5294 1295826003553 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 1295826003554 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 1295826003555 Short C-terminal domain; Region: SHOCT; pfam09851 1295826003556 putative DNA-binding protein; Validated; Region: PRK00118 1295826003557 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 1295826003558 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1295826003559 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1295826003560 active site 1295826003561 phosphorylation site [posttranslational modification] 1295826003562 intermolecular recognition site; other site 1295826003563 dimerization interface [polypeptide binding]; other site 1295826003564 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1295826003565 DNA binding site [nucleotide binding] 1295826003566 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1295826003567 dimer interface [polypeptide binding]; other site 1295826003568 phosphorylation site [posttranslational modification] 1295826003569 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1295826003570 ATP binding site [chemical binding]; other site 1295826003571 Mg2+ binding site [ion binding]; other site 1295826003572 G-X-G motif; other site 1295826003573 Domain of unknown function (DUF4395); Region: DUF4395; pfam14340 1295826003574 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1295826003575 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1295826003576 DNA-binding site [nucleotide binding]; DNA binding site 1295826003577 UTRA domain; Region: UTRA; pfam07702 1295826003578 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 1295826003579 active site 1295826003580 catalytic motif [active] 1295826003581 Zn binding site [ion binding]; other site 1295826003582 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 1295826003583 intersubunit interface [polypeptide binding]; other site 1295826003584 active site 1295826003585 catalytic residue [active] 1295826003586 pantothenate kinase; Provisional; Region: PRK05439 1295826003587 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 1295826003588 ATP-binding site [chemical binding]; other site 1295826003589 CoA-binding site [chemical binding]; other site 1295826003590 Mg2+-binding site [ion binding]; other site 1295826003591 Phosphate-starvation-inducible E; Region: PsiE; cl01264 1295826003592 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1295826003593 non-specific DNA binding site [nucleotide binding]; other site 1295826003594 salt bridge; other site 1295826003595 sequence-specific DNA binding site [nucleotide binding]; other site 1295826003596 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 1295826003597 ParB-like nuclease domain; Region: ParB; smart00470 1295826003598 Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969 1295826003599 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1295826003600 Active Sites [active] 1295826003601 Domain of unknown function (DUF3440); Region: DUF3440; pfam11922 1295826003602 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 1295826003603 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1295826003604 dimer interface [polypeptide binding]; other site 1295826003605 conserved gate region; other site 1295826003606 putative PBP binding loops; other site 1295826003607 ABC-ATPase subunit interface; other site 1295826003608 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 1295826003609 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1295826003610 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 1295826003611 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 1295826003612 Walker A/P-loop; other site 1295826003613 ATP binding site [chemical binding]; other site 1295826003614 Q-loop/lid; other site 1295826003615 ABC transporter signature motif; other site 1295826003616 Walker B; other site 1295826003617 D-loop; other site 1295826003618 H-loop/switch region; other site 1295826003619 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 1295826003620 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1295826003621 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1295826003622 DNA-binding site [nucleotide binding]; DNA binding site 1295826003623 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 1295826003624 TrkA-C domain; Region: TrkA_C; pfam02080 1295826003625 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1295826003626 beta-galactosidase; Region: BGL; TIGR03356 1295826003627 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 1295826003628 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1295826003629 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1295826003630 catalytic residue [active] 1295826003631 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1295826003632 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 1295826003633 active site 1295826003634 Protein of unknown function (DUF2806); Region: DUF2806; cl12560 1295826003635 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 1295826003636 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1295826003637 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1295826003638 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1295826003639 Glutamine amidotransferase class-I; Region: GATase; pfam00117 1295826003640 glutamine binding [chemical binding]; other site 1295826003641 catalytic triad [active] 1295826003642 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 1295826003643 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 1295826003644 dimer interface [polypeptide binding]; other site 1295826003645 FMN binding site [chemical binding]; other site 1295826003646 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1295826003647 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1295826003648 putative DNA binding site [nucleotide binding]; other site 1295826003649 putative Zn2+ binding site [ion binding]; other site 1295826003650 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 1295826003651 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1295826003652 EamA-like transporter family; Region: EamA; pfam00892 1295826003653 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1295826003654 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 1295826003655 DNA binding residues [nucleotide binding] 1295826003656 putative dimer interface [polypeptide binding]; other site 1295826003657 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1295826003658 classical (c) SDRs; Region: SDR_c; cd05233 1295826003659 NAD(P) binding site [chemical binding]; other site 1295826003660 active site 1295826003661 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK12315 1295826003662 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1295826003663 TPP-binding site; other site 1295826003664 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1295826003665 PYR/PP interface [polypeptide binding]; other site 1295826003666 dimer interface [polypeptide binding]; other site 1295826003667 TPP binding site [chemical binding]; other site 1295826003668 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1295826003669 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1295826003670 MarR family; Region: MarR; pfam01047 1295826003671 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 1295826003672 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 1295826003673 Cl binding site [ion binding]; other site 1295826003674 oligomer interface [polypeptide binding]; other site 1295826003675 Glycosyl hydrolase family 67 N-terminus; Region: Glyco_hydro_67N; pfam03648 1295826003676 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1295826003677 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1295826003678 dimer interface [polypeptide binding]; other site 1295826003679 conserved gate region; other site 1295826003680 ABC-ATPase subunit interface; other site 1295826003681 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1295826003682 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1295826003683 dimer interface [polypeptide binding]; other site 1295826003684 conserved gate region; other site 1295826003685 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1295826003686 ABC-ATPase subunit interface; other site 1295826003687 GMP synthase; Reviewed; Region: guaA; PRK00074 1295826003688 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1295826003689 AMP/PPi binding site [chemical binding]; other site 1295826003690 candidate oxyanion hole; other site 1295826003691 catalytic triad [active] 1295826003692 potential glutamine specificity residues [chemical binding]; other site 1295826003693 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1295826003694 ATP Binding subdomain [chemical binding]; other site 1295826003695 Dimerization subdomain; other site 1295826003696 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1295826003697 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1295826003698 nucleotide binding site [chemical binding]; other site 1295826003699 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1295826003700 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1295826003701 nucleotide binding site [chemical binding]; other site 1295826003702 butyrate kinase; Provisional; Region: PRK03011 1295826003703 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1295826003704 beta-galactosidase; Region: BGL; TIGR03356 1295826003705 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 1295826003706 sugar binding site [chemical binding]; other site 1295826003707 Endo-beta-N-acetylglucosaminidase D [Carbohydrate transport and metabolism]; Region: COG4724 1295826003708 Endo-beta-N-acetylglucosaminidase (ENGase) hydrolyzes the N-N'-diacetylchitobiosyl core of N-glycosylproteins. The beta-1,4-glycosyl bond located between two N-acetylglucosamine residues is hydrolyzed such that N-acetylglucosamine 1 remains with...; Region: GH85_ENGase; cd06547 1295826003709 putative active site [active] 1295826003710 FOG: PKD repeat [General function prediction only]; Region: COG3291 1295826003711 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1295826003712 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1295826003713 Ca binding site [ion binding]; other site 1295826003714 active site 1295826003715 catalytic site [active] 1295826003716 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1295826003717 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1295826003718 Domain of unknown function (DUF3502); Region: DUF3502; pfam12010 1295826003719 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1295826003720 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1295826003721 dimer interface [polypeptide binding]; other site 1295826003722 conserved gate region; other site 1295826003723 putative PBP binding loops; other site 1295826003724 ABC-ATPase subunit interface; other site 1295826003725 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1295826003726 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1295826003727 dimer interface [polypeptide binding]; other site 1295826003728 conserved gate region; other site 1295826003729 putative PBP binding loops; other site 1295826003730 ABC-ATPase subunit interface; other site 1295826003731 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 1295826003732 N-terminal catalytic domain of SPGH38, a putative alpha-mannosidase of Streptococcus pyogenes, and its prokaryotic homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_SpGH38_like; cd10814 1295826003733 active site 1295826003734 metal binding site [ion binding]; metal-binding site 1295826003735 homodimer interface [polypeptide binding]; other site 1295826003736 catalytic site [active] 1295826003737 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 1295826003738 Uncharacterized conserved protein [Function unknown]; Region: COG3538 1295826003739 Protein of unknown function (DUF1237); Region: DUF1237; pfam06824 1295826003740 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1295826003741 DNA-binding site [nucleotide binding]; DNA binding site 1295826003742 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1295826003743 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1295826003744 ligand binding site [chemical binding]; other site 1295826003745 dimerization interface [polypeptide binding]; other site 1295826003746 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 1295826003747 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 1295826003748 putative phosphoketolase; Provisional; Region: PRK05261 1295826003749 XFP N-terminal domain; Region: XFP_N; pfam09364 1295826003750 XFP C-terminal domain; Region: XFP_C; pfam09363 1295826003751 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1295826003752 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1295826003753 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1295826003754 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 1295826003755 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 1295826003756 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 1295826003757 active site 1295826003758 substrate binding site [chemical binding]; other site 1295826003759 trimer interface [polypeptide binding]; other site 1295826003760 CoA binding site [chemical binding]; other site 1295826003761 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1295826003762 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1295826003763 active site 1295826003764 catalytic tetrad [active] 1295826003765 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 1295826003766 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 1295826003767 inhibitor binding site; inhibition site 1295826003768 active site 1295826003769 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 1295826003770 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 1295826003771 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 1295826003772 active site 1295826003773 catalytic residues [active] 1295826003774 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 1295826003775 N- and C-terminal domain interface [polypeptide binding]; other site 1295826003776 D-xylulose kinase; Region: XylB; TIGR01312 1295826003777 active site 1295826003778 MgATP binding site [chemical binding]; other site 1295826003779 catalytic site [active] 1295826003780 metal binding site [ion binding]; metal-binding site 1295826003781 xylulose binding site [chemical binding]; other site 1295826003782 homodimer interface [polypeptide binding]; other site 1295826003783 Glycosyl hydrolases family 11; Region: Glyco_hydro_11; pfam00457 1295826003784 xylose isomerase; Provisional; Region: PRK05474 1295826003785 xylose isomerase; Region: xylose_isom_A; TIGR02630 1295826003786 Cupin domain; Region: Cupin_2; pfam07883 1295826003787 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1295826003788 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1295826003789 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 1295826003790 ATP-grasp domain; Region: ATP-grasp; pfam02222 1295826003791 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 1295826003792 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1295826003793 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1295826003794 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1295826003795 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 1295826003796 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1295826003797 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1295826003798 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1295826003799 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1295826003800 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1295826003801 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1295826003802 putative substrate translocation pore; other site 1295826003803 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1295826003804 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 1295826003805 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1295826003806 motif II; other site 1295826003807 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1295826003808 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1295826003809 purine monophosphate binding site [chemical binding]; other site 1295826003810 dimer interface [polypeptide binding]; other site 1295826003811 putative catalytic residues [active] 1295826003812 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1295826003813 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 1295826003814 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1295826003815 aldehyde reductase, extended (e) SDRs; Region: AR_SDR_e; cd05227 1295826003816 NADP binding site [chemical binding]; other site 1295826003817 putative substrate binding site [chemical binding]; other site 1295826003818 active site 1295826003819 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1295826003820 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1295826003821 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1295826003822 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1295826003823 Walker A/P-loop; other site 1295826003824 ATP binding site [chemical binding]; other site 1295826003825 Q-loop/lid; other site 1295826003826 ABC transporter signature motif; other site 1295826003827 Walker B; other site 1295826003828 D-loop; other site 1295826003829 H-loop/switch region; other site 1295826003830 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 1295826003831 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1295826003832 active site 1295826003833 substrate binding site [chemical binding]; other site 1295826003834 cosubstrate binding site; other site 1295826003835 catalytic site [active] 1295826003836 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1295826003837 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1295826003838 dimerization interface [polypeptide binding]; other site 1295826003839 putative ATP binding site [chemical binding]; other site 1295826003840 Predicted ATP-binding protein involved in virulence [General function prediction only]; Region: COG3950 1295826003841 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1295826003842 Walker A/P-loop; other site 1295826003843 ATP binding site [chemical binding]; other site 1295826003844 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1295826003845 ABC transporter signature motif; other site 1295826003846 Walker B; other site 1295826003847 D-loop; other site 1295826003848 H-loop/switch region; other site 1295826003849 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1295826003850 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 1295826003851 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1295826003852 AAA domain; Region: AAA_13; pfam13166 1295826003853 phage lambda Rz1-like protein; Region: PHA02047 1295826003854 type I restriction system adenine methylase (hsdM); Region: hsdM; TIGR00497 1295826003855 HsdM N-terminal domain; Region: HsdM_N; pfam12161 1295826003856 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1295826003857 S-adenosylmethionine binding site [chemical binding]; other site 1295826003858 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 1295826003859 Clp amino terminal domain; Region: Clp_N; pfam02861 1295826003860 Clp amino terminal domain; Region: Clp_N; pfam02861 1295826003861 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1295826003862 Walker A motif; other site 1295826003863 ATP binding site [chemical binding]; other site 1295826003864 Walker B motif; other site 1295826003865 arginine finger; other site 1295826003866 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1295826003867 Walker A motif; other site 1295826003868 ATP binding site [chemical binding]; other site 1295826003869 Walker B motif; other site 1295826003870 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1295826003871 amidophosphoribosyltransferase; Provisional; Region: PRK07272 1295826003872 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1295826003873 active site 1295826003874 tetramer interface [polypeptide binding]; other site 1295826003875 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1295826003876 active site 1295826003877 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 1295826003878 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1295826003879 putative active site [active] 1295826003880 catalytic triad [active] 1295826003881 Phosphoribosylformylglycinamidine (FGAM) synthase, PurS component [Nucleotide transport and metabolism]; Region: PurS; COG1828 1295826003882 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 1295826003883 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 1295826003884 ATP binding site [chemical binding]; other site 1295826003885 active site 1295826003886 substrate binding site [chemical binding]; other site 1295826003887 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1295826003888 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1295826003889 putative transporter; Provisional; Region: PRK10504 1295826003890 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1295826003891 putative substrate translocation pore; other site 1295826003892 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1295826003893 thymidylate synthase; Reviewed; Region: thyA; PRK01827 1295826003894 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1295826003895 dimerization interface [polypeptide binding]; other site 1295826003896 active site 1295826003897 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287 1295826003898 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1295826003899 catalytic Zn binding site [ion binding]; other site 1295826003900 NAD(P) binding site [chemical binding]; other site 1295826003901 structural Zn binding site [ion binding]; other site 1295826003902 Enterocin A Immunity; Region: EntA_Immun; pfam08951 1295826003903 Predicted membrane protein [Function unknown]; Region: COG4905 1295826003904 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 1295826003905 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 1295826003906 Dihydroorotate dehydrogenase (DHOD) class 1A FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1A_like; cd04741 1295826003907 active site 1295826003908 FMN binding site [chemical binding]; other site 1295826003909 substrate binding site [chemical binding]; other site 1295826003910 catalytic residues [active] 1295826003911 homodimer interface [polypeptide binding]; other site 1295826003912 Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225 1295826003913 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1295826003914 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1295826003915 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1295826003916 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1295826003917 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1295826003918 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1295826003919 dimerization interface [polypeptide binding]; other site 1295826003920 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 1295826003921 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 1295826003922 putative active site [active] 1295826003923 metal binding site [ion binding]; metal-binding site 1295826003924 Dipeptidase [Amino acid transport and metabolism]; Region: PepD; COG4690 1295826003925 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1295826003926 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1295826003927 Coenzyme A binding pocket [chemical binding]; other site 1295826003928 dihydrodipicolinate reductase; Provisional; Region: PRK00048 1295826003929 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1295826003930 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1295826003931 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4835 1295826003932 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1295826003933 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1295826003934 RimM N-terminal domain; Region: RimM; pfam01782 1295826003935 PRC-barrel domain; Region: PRC; pfam05239 1295826003936 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1295826003937 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1295826003938 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1295826003939 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 1295826003940 KH domain; Region: KH_4; pfam13083 1295826003941 Ribosomal protein S16 [Translation, ribosomal structure and biogenesis]; Region: RpsP; COG0228 1295826003942 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 1295826003943 homodimer interface [polypeptide binding]; other site 1295826003944 catalytic residues [active] 1295826003945 NAD binding site [chemical binding]; other site 1295826003946 substrate binding pocket [chemical binding]; other site 1295826003947 flexible flap; other site 1295826003948 putative acyltransferase; Provisional; Region: PRK05790 1295826003949 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1295826003950 dimer interface [polypeptide binding]; other site 1295826003951 active site 1295826003952 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1295826003953 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 1295826003954 active site 1295826003955 trimer interface [polypeptide binding]; other site 1295826003956 allosteric site; other site 1295826003957 active site lid [active] 1295826003958 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1295826003959 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 1295826003960 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 1295826003961 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1295826003962 non-specific DNA binding site [nucleotide binding]; other site 1295826003963 salt bridge; other site 1295826003964 sequence-specific DNA binding site [nucleotide binding]; other site 1295826003965 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 1295826003966 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 1295826003967 WxL domain surface cell wall-binding; Region: WxL; pfam13731 1295826003968 WxL domain surface cell wall-binding; Region: WxL; pfam13731 1295826003969 GTPase CgtA; Reviewed; Region: obgE; PRK12297 1295826003970 GTP1/OBG; Region: GTP1_OBG; pfam01018 1295826003971 Obg GTPase; Region: Obg; cd01898 1295826003972 G1 box; other site 1295826003973 GTP/Mg2+ binding site [chemical binding]; other site 1295826003974 Switch I region; other site 1295826003975 G2 box; other site 1295826003976 G3 box; other site 1295826003977 Switch II region; other site 1295826003978 G4 box; other site 1295826003979 G5 box; other site 1295826003980 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 1295826003981 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 1295826003982 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1295826003983 homodimer interface [polypeptide binding]; other site 1295826003984 active site 1295826003985 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 1295826003986 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002 1295826003987 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1295826003988 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1295826003989 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 1295826003990 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1295826003991 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 1295826003992 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1295826003993 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1295826003994 dimerization interface [polypeptide binding]; other site 1295826003995 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1295826003996 dimer interface [polypeptide binding]; other site 1295826003997 phosphorylation site [posttranslational modification] 1295826003998 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1295826003999 ATP binding site [chemical binding]; other site 1295826004000 Mg2+ binding site [ion binding]; other site 1295826004001 G-X-G motif; other site 1295826004002 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1295826004003 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1295826004004 active site 1295826004005 phosphorylation site [posttranslational modification] 1295826004006 intermolecular recognition site; other site 1295826004007 dimerization interface [polypeptide binding]; other site 1295826004008 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1295826004009 DNA binding site [nucleotide binding] 1295826004010 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 1295826004011 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 1295826004012 conserved hypothetical protein; Region: TIGR02328 1295826004013 Pyrimidine dimer DNA glycosylase; Region: Pyr_excise; pfam03013 1295826004014 CHAP domain; Region: CHAP; pfam05257 1295826004015 phosphodiesterase YaeI; Provisional; Region: PRK11340 1295826004016 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1295826004017 putative active site [active] 1295826004018 putative metal binding site [ion binding]; other site 1295826004019 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1295826004020 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1295826004021 active site 1295826004022 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 1295826004023 metal binding site [ion binding]; metal-binding site 1295826004024 Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553 1295826004025 Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553 1295826004026 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1295826004027 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 1295826004028 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1295826004029 catalytic site [active] 1295826004030 subunit interface [polypeptide binding]; other site 1295826004031 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 1295826004032 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1295826004033 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1295826004034 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 1295826004035 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 1295826004036 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1295826004037 active site 1295826004038 Peptidase M50B-like; Region: Peptidase_M50B; pfam13398 1295826004039 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1295826004040 dimerization interface [polypeptide binding]; other site 1295826004041 putative DNA binding site [nucleotide binding]; other site 1295826004042 putative Zn2+ binding site [ion binding]; other site 1295826004043 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 1295826004044 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 1295826004045 putative catalytic cysteine [active] 1295826004046 Uncharacterized conserved protein [Function unknown]; Region: COG2461 1295826004047 Family of unknown function (DUF438); Region: DUF438; pfam04282 1295826004048 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 1295826004049 Domain of unknown function (DUF1858); Region: DUF1858; pfam08984 1295826004050 Predicted membrane protein [Function unknown]; Region: COG4392 1295826004051 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 1295826004052 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 1295826004053 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 1295826004054 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1295826004055 spermidine N1-acetyltransferase; Provisional; Region: PRK15130 1295826004056 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1295826004057 Coenzyme A binding pocket [chemical binding]; other site 1295826004058 signal recognition particle protein; Provisional; Region: PRK10867 1295826004059 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1295826004060 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1295826004061 P loop; other site 1295826004062 GTP binding site [chemical binding]; other site 1295826004063 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1295826004064 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 1295826004065 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1295826004066 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1295826004067 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1295826004068 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 1295826004069 MgtC family; Region: MgtC; pfam02308 1295826004070 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1295826004071 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1295826004072 dimer interface [polypeptide binding]; other site 1295826004073 active site 1295826004074 catalytic residue [active] 1295826004075 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 1295826004076 nudix motif; other site 1295826004077 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 1295826004078 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1295826004079 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 1295826004080 amphipathic channel; other site 1295826004081 Asn-Pro-Ala signature motifs; other site 1295826004082 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 1295826004083 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1295826004084 TPP-binding site [chemical binding]; other site 1295826004085 dimer interface [polypeptide binding]; other site 1295826004086 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1295826004087 PYR/PP interface [polypeptide binding]; other site 1295826004088 dimer interface [polypeptide binding]; other site 1295826004089 TPP binding site [chemical binding]; other site 1295826004090 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1295826004091 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 1295826004092 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 1295826004093 active site 1295826004094 P-loop; other site 1295826004095 phosphorylation site [posttranslational modification] 1295826004096 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 1295826004097 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 1295826004098 active site 1295826004099 intersubunit interface [polypeptide binding]; other site 1295826004100 catalytic residue [active] 1295826004101 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1295826004102 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1295826004103 substrate binding site [chemical binding]; other site 1295826004104 ATP binding site [chemical binding]; other site 1295826004105 Glucuronate isomerase; Region: UxaC; pfam02614 1295826004106 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 1295826004107 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 1295826004108 active site 1295826004109 catalytic residues [active] 1295826004110 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 1295826004111 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1295826004112 putative substrate translocation pore; other site 1295826004113 mannonate dehydratase; Provisional; Region: PRK03906 1295826004114 mannonate dehydratase; Region: uxuA; TIGR00695 1295826004115 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 1295826004116 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1295826004117 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1295826004118 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1295826004119 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1295826004120 DNA-binding site [nucleotide binding]; DNA binding site 1295826004121 FCD domain; Region: FCD; pfam07729 1295826004122 Enterocin A Immunity; Region: EntA_Immun; pfam08951 1295826004123 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 1295826004124 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 1295826004125 ligand binding site [chemical binding]; other site 1295826004126 dimerization interface [polypeptide binding]; other site 1295826004127 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1295826004128 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1295826004129 TM-ABC transporter signature motif; other site 1295826004130 D-ribose pyranase; Provisional; Region: PRK11797 1295826004131 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1295826004132 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1295826004133 substrate binding site [chemical binding]; other site 1295826004134 dimer interface [polypeptide binding]; other site 1295826004135 ATP binding site [chemical binding]; other site 1295826004136 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1295826004137 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1295826004138 DNA binding site [nucleotide binding] 1295826004139 domain linker motif; other site 1295826004140 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1295826004141 dimerization interface [polypeptide binding]; other site 1295826004142 ligand binding site [chemical binding]; other site 1295826004143 adenylosuccinate lyase; Provisional; Region: PRK07492 1295826004144 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 1295826004145 tetramer interface [polypeptide binding]; other site 1295826004146 active site 1295826004147 Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998 1295826004148 Protein of unknown function (DUF2969); Region: DUF2969; pfam11184 1295826004149 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1295826004150 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1295826004151 catalytic residues [active] 1295826004152 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 1295826004153 MutS domain III; Region: MutS_III; pfam05192 1295826004154 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 1295826004155 Walker A/P-loop; other site 1295826004156 ATP binding site [chemical binding]; other site 1295826004157 Q-loop/lid; other site 1295826004158 ABC transporter signature motif; other site 1295826004159 Walker B; other site 1295826004160 D-loop; other site 1295826004161 H-loop/switch region; other site 1295826004162 Smr domain; Region: Smr; pfam01713 1295826004163 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 1295826004164 Colicin V production protein; Region: Colicin_V; pfam02674 1295826004165 catabolite control protein A; Region: ccpA; TIGR01481 1295826004166 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1295826004167 DNA binding site [nucleotide binding] 1295826004168 domain linker motif; other site 1295826004169 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 1295826004170 dimerization interface [polypeptide binding]; other site 1295826004171 effector binding site; other site 1295826004172 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1295826004173 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1295826004174 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1295826004175 active site 1295826004176 cell division protein GpsB; Provisional; Region: PRK14127 1295826004177 DivIVA domain; Region: DivI1A_domain; TIGR03544 1295826004178 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 1295826004179 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 1295826004180 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 1295826004181 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1295826004182 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1295826004183 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 1295826004184 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1295826004185 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1295826004186 active site 1295826004187 motif I; other site 1295826004188 motif II; other site 1295826004189 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 1295826004190 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 1295826004191 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 1295826004192 ATP-binding site [chemical binding]; other site 1295826004193 Sugar specificity; other site 1295826004194 Pyrimidine base specificity; other site 1295826004195 Cpl-7 lysozyme C-terminal domain; Region: Cpl-7; smart01095 1295826004196 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 1295826004197 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Provisional; Region: PRK13387 1295826004198 UbiA prenyltransferase family; Region: UbiA; pfam01040 1295826004199 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 1295826004200 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1295826004201 Cl- selectivity filter; other site 1295826004202 Cl- binding residues [ion binding]; other site 1295826004203 pore gating glutamate residue; other site 1295826004204 dimer interface [polypeptide binding]; other site 1295826004205 H+/Cl- coupling transport residue; other site 1295826004206 TrkA-C domain; Region: TrkA_C; pfam02080 1295826004207 Enterocin A Immunity; Region: EntA_Immun; pfam08951 1295826004208 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 1295826004209 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1295826004210 S-adenosylmethionine binding site [chemical binding]; other site 1295826004211 Predicted membrane protein [Function unknown]; Region: COG1511 1295826004212 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1295826004213 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 1295826004214 6-phospho-beta-glucosidase; Reviewed; Region: arb; PRK09593 1295826004215 beta-galactosidase; Region: BGL; TIGR03356 1295826004216 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK12315 1295826004217 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1295826004218 TPP-binding site; other site 1295826004219 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1295826004220 PYR/PP interface [polypeptide binding]; other site 1295826004221 dimer interface [polypeptide binding]; other site 1295826004222 TPP binding site [chemical binding]; other site 1295826004223 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1295826004224 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1295826004225 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1295826004226 dimer interface [polypeptide binding]; other site 1295826004227 phosphorylation site [posttranslational modification] 1295826004228 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1295826004229 ATP binding site [chemical binding]; other site 1295826004230 Mg2+ binding site [ion binding]; other site 1295826004231 G-X-G motif; other site 1295826004232 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1295826004233 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1295826004234 active site 1295826004235 phosphorylation site [posttranslational modification] 1295826004236 intermolecular recognition site; other site 1295826004237 dimerization interface [polypeptide binding]; other site 1295826004238 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1295826004239 DNA binding site [nucleotide binding] 1295826004240 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1295826004241 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1295826004242 DNA binding site [nucleotide binding] 1295826004243 domain linker motif; other site 1295826004244 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 1295826004245 putative dimerization interface [polypeptide binding]; other site 1295826004246 putative ligand binding site [chemical binding]; other site 1295826004247 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1295826004248 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1295826004249 Ca binding site [ion binding]; other site 1295826004250 active site 1295826004251 catalytic site [active] 1295826004252 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1295826004253 Alpha amylase catalytic domain found in bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac2_AmyA; cd11316 1295826004254 Ca binding site [ion binding]; other site 1295826004255 active site 1295826004256 catalytic site [active] 1295826004257 maltose O-acetyltransferase; Provisional; Region: PRK10092 1295826004258 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 1295826004259 active site 1295826004260 substrate binding site [chemical binding]; other site 1295826004261 trimer interface [polypeptide binding]; other site 1295826004262 CoA binding site [chemical binding]; other site 1295826004263 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1295826004264 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1295826004265 Ca binding site [ion binding]; other site 1295826004266 active site 1295826004267 catalytic site [active] 1295826004268 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 1295826004269 homodimer interface [polypeptide binding]; other site 1295826004270 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 1295826004271 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1295826004272 active site 1295826004273 homodimer interface [polypeptide binding]; other site 1295826004274 catalytic site [active] 1295826004275 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1295826004276 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1295826004277 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1295826004278 dimer interface [polypeptide binding]; other site 1295826004279 conserved gate region; other site 1295826004280 putative PBP binding loops; other site 1295826004281 ABC-ATPase subunit interface; other site 1295826004282 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1295826004283 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1295826004284 dimer interface [polypeptide binding]; other site 1295826004285 conserved gate region; other site 1295826004286 putative PBP binding loops; other site 1295826004287 ABC-ATPase subunit interface; other site 1295826004288 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1295826004289 Repair protein; Region: Repair_PSII; pfam04536 1295826004290 LssY C-terminus; Region: LssY_C; pfam14067 1295826004291 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1295826004292 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1295826004293 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1295826004294 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1295826004295 carbamate kinase; Reviewed; Region: PRK12686 1295826004296 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 1295826004297 putative substrate binding site [chemical binding]; other site 1295826004298 nucleotide binding site [chemical binding]; other site 1295826004299 nucleotide binding site [chemical binding]; other site 1295826004300 homodimer interface [polypeptide binding]; other site 1295826004301 agmatine deiminase; Provisional; Region: PRK13551 1295826004302 agmatine deiminase; Region: agmatine_aguA; TIGR03380 1295826004303 putrescine carbamoyltransferase; Provisional; Region: PRK02255 1295826004304 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1295826004305 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1295826004306 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1295826004307 DNA binding residues [nucleotide binding] 1295826004308 dimerization interface [polypeptide binding]; other site 1295826004309 Isochorismatase family; Region: Isochorismatase; pfam00857 1295826004310 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 1295826004311 catalytic triad [active] 1295826004312 dimer interface [polypeptide binding]; other site 1295826004313 conserved cis-peptide bond; other site 1295826004314 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1295826004315 cytidylate kinase; Provisional; Region: cmk; PRK00023 1295826004316 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1295826004317 CMP-binding site; other site 1295826004318 The sites determining sugar specificity; other site 1295826004319 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1295826004320 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 1295826004321 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 1295826004322 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 1295826004323 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1295826004324 active pocket/dimerization site; other site 1295826004325 active site 1295826004326 phosphorylation site [posttranslational modification] 1295826004327 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 1295826004328 active site 1295826004329 phosphorylation site [posttranslational modification] 1295826004330 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 1295826004331 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4687 1295826004332 Domain of unknown function (DUF956); Region: DUF956; cl01917 1295826004333 seryl-tRNA synthetase; Provisional; Region: PRK05431 1295826004334 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1295826004335 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1295826004336 dimer interface [polypeptide binding]; other site 1295826004337 active site 1295826004338 motif 1; other site 1295826004339 motif 2; other site 1295826004340 motif 3; other site 1295826004341 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1295826004342 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1295826004343 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1295826004344 Walker A/P-loop; other site 1295826004345 ATP binding site [chemical binding]; other site 1295826004346 Q-loop/lid; other site 1295826004347 ABC transporter signature motif; other site 1295826004348 Walker B; other site 1295826004349 D-loop; other site 1295826004350 H-loop/switch region; other site 1295826004351 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1295826004352 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 1295826004353 FeS/SAM binding site; other site 1295826004354 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1295826004355 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 1295826004356 putative dimer interface [polypeptide binding]; other site 1295826004357 catalytic triad [active] 1295826004358 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1295826004359 catalytic core [active] 1295826004360 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 1295826004361 PhoU domain; Region: PhoU; pfam01895 1295826004362 PhoU domain; Region: PhoU; pfam01895 1295826004363 phosphate transporter ATP-binding protein; Provisional; Region: PRK14239 1295826004364 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1295826004365 Walker A/P-loop; other site 1295826004366 ATP binding site [chemical binding]; other site 1295826004367 Q-loop/lid; other site 1295826004368 ABC transporter signature motif; other site 1295826004369 Walker B; other site 1295826004370 D-loop; other site 1295826004371 H-loop/switch region; other site 1295826004372 phosphate transporter ATP-binding protein; Provisional; Region: PRK14237 1295826004373 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1295826004374 Walker A/P-loop; other site 1295826004375 ATP binding site [chemical binding]; other site 1295826004376 Q-loop/lid; other site 1295826004377 ABC transporter signature motif; other site 1295826004378 Walker B; other site 1295826004379 D-loop; other site 1295826004380 H-loop/switch region; other site 1295826004381 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 1295826004382 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1295826004383 dimer interface [polypeptide binding]; other site 1295826004384 conserved gate region; other site 1295826004385 putative PBP binding loops; other site 1295826004386 ABC-ATPase subunit interface; other site 1295826004387 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 1295826004388 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1295826004389 dimer interface [polypeptide binding]; other site 1295826004390 conserved gate region; other site 1295826004391 putative PBP binding loops; other site 1295826004392 ABC-ATPase subunit interface; other site 1295826004393 PBP superfamily domain; Region: PBP_like_2; cl17296 1295826004394 PBP superfamily domain; Region: PBP_like_2; cl17296 1295826004395 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1295826004396 SmpB-tmRNA interface; other site 1295826004397 Predicted transcriptional regulators [Transcription]; Region: COG1733 1295826004398 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1295826004399 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1295826004400 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1295826004401 motif 1; other site 1295826004402 active site 1295826004403 motif 2; other site 1295826004404 motif 3; other site 1295826004405 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1295826004406 DHHA1 domain; Region: DHHA1; pfam02272 1295826004407 foldase protein PrsA; Reviewed; Region: PRK12450 1295826004408 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1295826004409 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1295826004410 S-adenosylmethionine binding site [chemical binding]; other site 1295826004411 Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164 1295826004412 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 1295826004413 active site 1295826004414 Zn binding site [ion binding]; other site 1295826004415 Competence protein CoiA-like family; Region: CoiA; pfam06054 1295826004416 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1295826004417 putative active site [active] 1295826004418 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 1295826004419 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1295826004420 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1295826004421 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1295826004422 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1295826004423 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1295826004424 active site 1295826004425 motif I; other site 1295826004426 motif II; other site 1295826004427 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 1295826004428 CoB--CoM heterodisulfide reductase, subunit B; Region: CoB_CoM_SS_B; TIGR03288 1295826004429 Cysteine-rich domain; Region: CCG; pfam02754 1295826004430 Cysteine-rich domain; Region: CCG; pfam02754 1295826004431 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 1295826004432 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 1295826004433 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 1295826004434 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1295826004435 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 1295826004436 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1295826004437 Zn2+ binding site [ion binding]; other site 1295826004438 Mg2+ binding site [ion binding]; other site 1295826004439 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1295826004440 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1295826004441 catalytic core [active] 1295826004442 prephenate dehydratase; Provisional; Region: PRK11898 1295826004443 Prephenate dehydratase; Region: PDT; pfam00800 1295826004444 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1295826004445 putative L-Phe binding site [chemical binding]; other site 1295826004446 shikimate kinase; Reviewed; Region: aroK; PRK00131 1295826004447 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1295826004448 ADP binding site [chemical binding]; other site 1295826004449 magnesium binding site [ion binding]; other site 1295826004450 putative shikimate binding site; other site 1295826004451 prephenate dehydrogenase; Validated; Region: PRK06545 1295826004452 prephenate dehydrogenase; Validated; Region: PRK08507 1295826004453 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 1295826004454 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1295826004455 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1295826004456 ATP binding site [chemical binding]; other site 1295826004457 Mg2+ binding site [ion binding]; other site 1295826004458 G-X-G motif; other site 1295826004459 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1295826004460 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1295826004461 active site 1295826004462 phosphorylation site [posttranslational modification] 1295826004463 intermolecular recognition site; other site 1295826004464 dimerization interface [polypeptide binding]; other site 1295826004465 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1295826004466 DNA binding site [nucleotide binding] 1295826004467 Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767 1295826004468 FtsX-like permease family; Region: FtsX; pfam02687 1295826004469 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1295826004470 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1295826004471 Walker A/P-loop; other site 1295826004472 ATP binding site [chemical binding]; other site 1295826004473 Q-loop/lid; other site 1295826004474 ABC transporter signature motif; other site 1295826004475 Walker B; other site 1295826004476 D-loop; other site 1295826004477 H-loop/switch region; other site 1295826004478 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5294 1295826004479 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1295826004480 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 1295826004481 Tetramer interface [polypeptide binding]; other site 1295826004482 active site 1295826004483 FMN-binding site [chemical binding]; other site 1295826004484 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 1295826004485 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1295826004486 motif II; other site 1295826004487 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493 1295826004488 Protein of unknown function (DUF1054); Region: DUF1054; pfam06335 1295826004489 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 1295826004490 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1295826004491 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1295826004492 shikimate binding site; other site 1295826004493 NAD(P) binding site [chemical binding]; other site 1295826004494 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1295826004495 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1295826004496 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1295826004497 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1295826004498 substrate binding pocket [chemical binding]; other site 1295826004499 membrane-bound complex binding site; other site 1295826004500 hinge residues; other site 1295826004501 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1295826004502 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1295826004503 substrate binding pocket [chemical binding]; other site 1295826004504 membrane-bound complex binding site; other site 1295826004505 hinge residues; other site 1295826004506 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1295826004507 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1295826004508 dimer interface [polypeptide binding]; other site 1295826004509 conserved gate region; other site 1295826004510 putative PBP binding loops; other site 1295826004511 ABC-ATPase subunit interface; other site 1295826004512 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1295826004513 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1295826004514 Walker A/P-loop; other site 1295826004515 ATP binding site [chemical binding]; other site 1295826004516 Q-loop/lid; other site 1295826004517 ABC transporter signature motif; other site 1295826004518 Walker B; other site 1295826004519 D-loop; other site 1295826004520 H-loop/switch region; other site 1295826004521 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 1295826004522 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1295826004523 gamma subunit interface [polypeptide binding]; other site 1295826004524 epsilon subunit interface [polypeptide binding]; other site 1295826004525 LBP interface [polypeptide binding]; other site 1295826004526 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1295826004527 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1295826004528 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1295826004529 alpha subunit interaction interface [polypeptide binding]; other site 1295826004530 Walker A motif; other site 1295826004531 ATP binding site [chemical binding]; other site 1295826004532 Walker B motif; other site 1295826004533 inhibitor binding site; inhibition site 1295826004534 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1295826004535 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1295826004536 core domain interface [polypeptide binding]; other site 1295826004537 delta subunit interface [polypeptide binding]; other site 1295826004538 epsilon subunit interface [polypeptide binding]; other site 1295826004539 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1295826004540 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1295826004541 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1295826004542 beta subunit interaction interface [polypeptide binding]; other site 1295826004543 Walker A motif; other site 1295826004544 ATP binding site [chemical binding]; other site 1295826004545 Walker B motif; other site 1295826004546 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1295826004547 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 1295826004548 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 1295826004549 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 1295826004550 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 1295826004551 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 1295826004552 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 1295826004553 F0F1 ATP synthase subunit C; Provisional; Region: PRK13466 1295826004554 Predicted esterase [General function prediction only]; Region: COG0627 1295826004555 S-formylglutathione hydrolase; Region: PLN02442 1295826004556 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 1295826004557 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 1295826004558 Competence protein; Region: Competence; pfam03772 1295826004559 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 1295826004560 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1295826004561 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 1295826004562 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 1295826004563 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 1295826004564 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1295826004565 Walker A/P-loop; other site 1295826004566 ATP binding site [chemical binding]; other site 1295826004567 Q-loop/lid; other site 1295826004568 ABC transporter signature motif; other site 1295826004569 Walker B; other site 1295826004570 D-loop; other site 1295826004571 H-loop/switch region; other site 1295826004572 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 1295826004573 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1295826004574 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1295826004575 transmembrane helices; other site 1295826004576 Putative transcription activator [Transcription]; Region: TenA; COG0819 1295826004577 Zinc finger domain containing protein (CHY type) [Function unknown]; Region: COG4357 1295826004578 CHY zinc finger; Region: zf-CHY; pfam05495 1295826004579 BioY family; Region: BioY; pfam02632 1295826004580 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1295826004581 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1295826004582 NAD(P) binding site [chemical binding]; other site 1295826004583 active site 1295826004584 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 1295826004585 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1295826004586 FMN binding site [chemical binding]; other site 1295826004587 substrate binding site [chemical binding]; other site 1295826004588 putative catalytic residue [active] 1295826004589 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1295826004590 type VII secretion protein EsaA, N-terminal domain; Region: T7_esaA_Nterm; TIGR03929 1295826004591 Domain of unknown function (DUF4176); Region: DUF4176; pfam13780 1295826004592 LXG domain of WXG superfamily; Region: LXG; pfam04740 1295826004593 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 1295826004594 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1295826004595 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1295826004596 type VII secretion protein EssB; Region: T7_EssB; TIGR03926 1295826004597 WXG100 protein secretion system (Wss), protein YukC; Region: YukC; cl01868 1295826004598 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; pfam08817 1295826004599 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 1295826004600 phage holin, LL-H family; Region: holin_LLH; TIGR01673 1295826004601 Phage tail protein; Region: Sipho_tail; pfam05709 1295826004602 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 1295826004603 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1295826004604 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1295826004605 catalytic residue [active] 1295826004606 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 1295826004607 Protein of unknown function (DUF1268); Region: DUF1268; pfam06896 1295826004608 Phage major tail protein; Region: Phage_tail; pfam04630 1295826004609 Bacteriophage protein of unknown function (DUF646); Region: DUF646; pfam04883 1295826004610 Phage head-tail joining protein; Region: Phage_H_T_join; cl11461 1295826004611 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 1295826004612 oligomerization interface [polypeptide binding]; other site 1295826004613 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 1295826004614 Phage capsid family; Region: Phage_capsid; pfam05065 1295826004615 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 1295826004616 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 1295826004617 oligomer interface [polypeptide binding]; other site 1295826004618 active site residues [active] 1295826004619 Phage-related protein [Function unknown]; Region: COG4695 1295826004620 Phage portal protein; Region: Phage_portal; pfam04860 1295826004621 Phage Terminase; Region: Terminase_1; pfam03354 1295826004622 Phage terminase, small subunit [DNA replication, recombination, and repair]; Region: COG3747 1295826004623 Protein of unknown function (DUF722); Region: DUF722; pfam05263 1295826004624 Prophage protein (DUF1660); Region: DUF1660; pfam07874 1295826004625 Protein of unknown function (DUF1125); Region: DUF1125; pfam06563 1295826004626 Protein of unknown function (DUF1497); Region: DUF1497; pfam07384 1295826004627 VRR-NUC domain; Region: VRR_NUC; pfam08774 1295826004628 D5 N terminal like; Region: D5_N; smart00885 1295826004629 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 1295826004630 Poxvirus D5 protein-like; Region: Pox_D5; pfam03288 1295826004631 Protein of unknown function (DUF669); Region: DUF669; pfam05037 1295826004632 phage nucleotide-binding protein; Region: phage_P_loop; TIGR01618 1295826004633 AAA domain; Region: AAA_24; pfam13479 1295826004634 Siphovirus Gp157; Region: Sipho_Gp157; pfam05565 1295826004635 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1295826004636 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1295826004637 non-specific DNA binding site [nucleotide binding]; other site 1295826004638 salt bridge; other site 1295826004639 sequence-specific DNA binding site [nucleotide binding]; other site 1295826004640 Lactococcus bacteriophage repressor; Region: Lac_bphage_repr; pfam06543 1295826004641 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1295826004642 active site 1295826004643 DNA binding site [nucleotide binding] 1295826004644 Int/Topo IB signature motif; other site 1295826004645 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 1295826004646 FeS assembly protein SufB; Region: sufB; TIGR01980 1295826004647 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1295826004648 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1295826004649 trimerization site [polypeptide binding]; other site 1295826004650 active site 1295826004651 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1295826004652 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1295826004653 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1295826004654 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1295826004655 catalytic residue [active] 1295826004656 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 1295826004657 FeS assembly protein SufD; Region: sufD; TIGR01981 1295826004658 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 1295826004659 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 1295826004660 Walker A/P-loop; other site 1295826004661 ATP binding site [chemical binding]; other site 1295826004662 Q-loop/lid; other site 1295826004663 ABC transporter signature motif; other site 1295826004664 Walker B; other site 1295826004665 D-loop; other site 1295826004666 H-loop/switch region; other site 1295826004667 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 1295826004668 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 1295826004669 Mg++ binding site [ion binding]; other site 1295826004670 putative catalytic motif [active] 1295826004671 substrate binding site [chemical binding]; other site 1295826004672 Negative regulator of genetic competence, sporulation and motility [Posttranslational modification, protein turnover, chaperones / Signal transduction mechanisms / Cell motility and secretion]; Region: MecA; COG4862 1295826004673 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1295826004674 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1295826004675 Walker A/P-loop; other site 1295826004676 ATP binding site [chemical binding]; other site 1295826004677 Q-loop/lid; other site 1295826004678 ABC transporter signature motif; other site 1295826004679 Walker B; other site 1295826004680 D-loop; other site 1295826004681 H-loop/switch region; other site 1295826004682 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 1295826004683 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1295826004684 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 1295826004685 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1295826004686 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1295826004687 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1295826004688 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1295826004689 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1295826004690 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 1295826004691 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1295826004692 G-loop; other site 1295826004693 DNA binding site [nucleotide binding] 1295826004694 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1295826004695 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1295826004696 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1295826004697 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1295826004698 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1295826004699 RPB1 interaction site [polypeptide binding]; other site 1295826004700 RPB10 interaction site [polypeptide binding]; other site 1295826004701 RPB11 interaction site [polypeptide binding]; other site 1295826004702 RPB3 interaction site [polypeptide binding]; other site 1295826004703 RPB12 interaction site [polypeptide binding]; other site 1295826004704 CodY GAF-like domain; Region: CodY; pfam06018 1295826004705 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1295826004706 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1295826004707 non-specific DNA binding site [nucleotide binding]; other site 1295826004708 salt bridge; other site 1295826004709 sequence-specific DNA binding site [nucleotide binding]; other site 1295826004710 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1295826004711 active site 1295826004712 DNA binding site [nucleotide binding] 1295826004713 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1295826004714 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 1295826004715 UDP-N-acetylmuramoylalanyl-D-glutamate--L-lysine ligase; Provisional; Region: PRK14022 1295826004716 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1295826004717 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1295826004718 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1295826004719 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 1295826004720 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 1295826004721 NAD binding site [chemical binding]; other site 1295826004722 substrate binding site [chemical binding]; other site 1295826004723 catalytic Zn binding site [ion binding]; other site 1295826004724 tetramer interface [polypeptide binding]; other site 1295826004725 structural Zn binding site [ion binding]; other site 1295826004726 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 1295826004727 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1295826004728 ATP binding site [chemical binding]; other site 1295826004729 putative Mg++ binding site [ion binding]; other site 1295826004730 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1295826004731 nucleotide binding region [chemical binding]; other site 1295826004732 ATP-binding site [chemical binding]; other site 1295826004733 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 1295826004734 HRDC domain; Region: HRDC; pfam00570 1295826004735 inner membrane transporter YjeM; Provisional; Region: PRK15238 1295826004736 peptidase T; Region: peptidase-T; TIGR01882 1295826004737 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 1295826004738 metal binding site [ion binding]; metal-binding site 1295826004739 dimer interface [polypeptide binding]; other site 1295826004740 Domain of unknown function (DUF1803); Region: DUF1803; pfam08820 1295826004741 Domain of unknown function (DUF1803); Region: DUF1803; pfam08820 1295826004742 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 1295826004743 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1295826004744 FeS/SAM binding site; other site 1295826004745 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1295826004746 Domain of unknown function DUF21; Region: DUF21; pfam01595 1295826004747 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1295826004748 Transporter associated domain; Region: CorC_HlyC; smart01091 1295826004749 Transcriptional regulator; Region: Rrf2; pfam02082 1295826004750 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1295826004751 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1295826004752 NAD(P) binding site [chemical binding]; other site 1295826004753 active site 1295826004754 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1295826004755 Coenzyme A binding pocket [chemical binding]; other site 1295826004756 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033 1295826004757 putative uracil binding site [chemical binding]; other site 1295826004758 putative active site [active] 1295826004759 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1295826004760 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1295826004761 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1295826004762 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1295826004763 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1295826004764 catalytic core [active] 1295826004765 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 1295826004766 GIY-YIG motif/motif A; other site 1295826004767 putative active site [active] 1295826004768 putative metal binding site [ion binding]; other site 1295826004769 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1295826004770 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1295826004771 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1295826004772 Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564 1295826004773 Thiamine pyrophosphokinase; Region: TPK; cd07995 1295826004774 active site 1295826004775 dimerization interface [polypeptide binding]; other site 1295826004776 thiamine binding site [chemical binding]; other site 1295826004777 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u4; cd11541 1295826004778 putative metal binding site [ion binding]; other site 1295826004779 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 1295826004780 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 1295826004781 putative dimer interface [polypeptide binding]; other site 1295826004782 putative anticodon binding site; other site 1295826004783 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 1295826004784 homodimer interface [polypeptide binding]; other site 1295826004785 motif 1; other site 1295826004786 motif 2; other site 1295826004787 active site 1295826004788 motif 3; other site 1295826004789 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 1295826004790 GIY-YIG motif/motif A; other site 1295826004791 active site 1295826004792 catalytic site [active] 1295826004793 metal binding site [ion binding]; metal-binding site 1295826004794 aspartate aminotransferase; Provisional; Region: PRK05764 1295826004795 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1295826004796 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1295826004797 homodimer interface [polypeptide binding]; other site 1295826004798 catalytic residue [active] 1295826004799 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 1295826004800 DnaQ family exonuclease/DinG family helicase, putative; Region: dinG_rel; TIGR01407 1295826004801 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1295826004802 active site 1295826004803 catalytic site [active] 1295826004804 substrate binding site [chemical binding]; other site 1295826004805 DEAD/DEAH box helicase; Region: DEAD; pfam00270 1295826004806 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1295826004807 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1295826004808 Ligand Binding Site [chemical binding]; other site 1295826004809 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1295826004810 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1295826004811 dimer interface [polypeptide binding]; other site 1295826004812 conserved gate region; other site 1295826004813 putative PBP binding loops; other site 1295826004814 ABC-ATPase subunit interface; other site 1295826004815 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1295826004816 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1295826004817 dimer interface [polypeptide binding]; other site 1295826004818 conserved gate region; other site 1295826004819 putative PBP binding loops; other site 1295826004820 ABC-ATPase subunit interface; other site 1295826004821 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1295826004822 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1295826004823 Walker A/P-loop; other site 1295826004824 ATP binding site [chemical binding]; other site 1295826004825 Q-loop/lid; other site 1295826004826 ABC transporter signature motif; other site 1295826004827 Walker B; other site 1295826004828 D-loop; other site 1295826004829 H-loop/switch region; other site 1295826004830 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1295826004831 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1295826004832 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1295826004833 Walker A/P-loop; other site 1295826004834 ATP binding site [chemical binding]; other site 1295826004835 Q-loop/lid; other site 1295826004836 ABC transporter signature motif; other site 1295826004837 Walker B; other site 1295826004838 D-loop; other site 1295826004839 H-loop/switch region; other site 1295826004840 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1295826004841 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1295826004842 23S rRNA binding site [nucleotide binding]; other site 1295826004843 L21 binding site [polypeptide binding]; other site 1295826004844 L13 binding site [polypeptide binding]; other site 1295826004845 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1295826004846 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 1295826004847 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1295826004848 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1295826004849 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 1295826004850 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1295826004851 motif II; other site 1295826004852 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 1295826004853 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 1295826004854 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 1295826004855 Protein of unknown function (DUF1033); Region: DUF1033; pfam06279 1295826004856 Ribonuclease III family protein [Replication, recombination, and repair]; Region: COG1939 1295826004857 active site 1295826004858 metal binding site [ion binding]; metal-binding site 1295826004859 dimerization interface [polypeptide binding]; other site 1295826004860 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 1295826004861 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 1295826004862 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1295826004863 trimer interface [polypeptide binding]; other site 1295826004864 active site 1295826004865 substrate binding site [chemical binding]; other site 1295826004866 CoA binding site [chemical binding]; other site 1295826004867 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 1295826004868 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 1295826004869 RNase E interface [polypeptide binding]; other site 1295826004870 trimer interface [polypeptide binding]; other site 1295826004871 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1295826004872 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1295826004873 RNase E interface [polypeptide binding]; other site 1295826004874 trimer interface [polypeptide binding]; other site 1295826004875 active site 1295826004876 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1295826004877 putative nucleic acid binding region [nucleotide binding]; other site 1295826004878 G-X-X-G motif; other site 1295826004879 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1295826004880 RNA binding site [nucleotide binding]; other site 1295826004881 domain interface; other site 1295826004882 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02458 1295826004883 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1295826004884 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1295826004885 active site 1295826004886 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1295826004887 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1295826004888 catalytic residue [active] 1295826004889 Putative amino acid metabolism; Region: DUF1831; pfam08866 1295826004890 elongation factor Tu; Reviewed; Region: PRK00049 1295826004891 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1295826004892 G1 box; other site 1295826004893 GEF interaction site [polypeptide binding]; other site 1295826004894 GTP/Mg2+ binding site [chemical binding]; other site 1295826004895 Switch I region; other site 1295826004896 G2 box; other site 1295826004897 G3 box; other site 1295826004898 Switch II region; other site 1295826004899 G4 box; other site 1295826004900 G5 box; other site 1295826004901 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1295826004902 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1295826004903 Antibiotic Binding Site [chemical binding]; other site 1295826004904 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 1295826004905 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1295826004906 active site 1295826004907 HIGH motif; other site 1295826004908 nucleotide binding site [chemical binding]; other site 1295826004909 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1295826004910 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1295826004911 active site 1295826004912 KMSKS motif; other site 1295826004913 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 1295826004914 tRNA binding surface [nucleotide binding]; other site 1295826004915 anticodon binding site; other site 1295826004916 DivIVA protein; Region: DivIVA; pfam05103 1295826004917 DivIVA domain; Region: DivI1A_domain; TIGR03544 1295826004918 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 1295826004919 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1295826004920 RNA binding surface [nucleotide binding]; other site 1295826004921 YGGT family; Region: YGGT; pfam02325 1295826004922 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 1295826004923 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 1295826004924 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1295826004925 catalytic residue [active] 1295826004926 cell division protein FtsZ; Validated; Region: PRK09330 1295826004927 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1295826004928 nucleotide binding site [chemical binding]; other site 1295826004929 SulA interaction site; other site 1295826004930 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 1295826004931 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1295826004932 nucleotide binding site [chemical binding]; other site 1295826004933 Cell division protein FtsA; Region: FtsA; pfam14450 1295826004934 Domain of unknown function (DUF3484); Region: DUF3484; pfam11983 1295826004935 EDD domain protein, DegV family; Region: DegV; TIGR00762 1295826004936 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1295826004937 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1295826004938 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1295826004939 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1295826004940 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1295826004941 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1295826004942 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1295826004943 active site 1295826004944 catalytic tetrad [active] 1295826004945 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1295826004946 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1295826004947 putative substrate translocation pore; other site 1295826004948 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1295826004949 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1295826004950 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1295826004951 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1295826004952 dimerization interface [polypeptide binding]; other site 1295826004953 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 1295826004954 trimer interface [polypeptide binding]; other site 1295826004955 active site 1295826004956 G bulge; other site 1295826004957 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 1295826004958 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 1295826004959 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1295826004960 dimer interface [polypeptide binding]; other site 1295826004961 ADP-ribose binding site [chemical binding]; other site 1295826004962 active site 1295826004963 nudix motif; other site 1295826004964 metal binding site [ion binding]; metal-binding site 1295826004965 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 1295826004966 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1295826004967 Substrate binding site; other site 1295826004968 Mg++ binding site; other site 1295826004969 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1295826004970 active site 1295826004971 substrate binding site [chemical binding]; other site 1295826004972 CoA binding site [chemical binding]; other site 1295826004973 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 1295826004974 pyrroline-5-carboxylate reductase; Region: PLN02688 1295826004975 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1295826004976 16S/18S rRNA binding site [nucleotide binding]; other site 1295826004977 S13e-L30e interaction site [polypeptide binding]; other site 1295826004978 25S rRNA binding site [nucleotide binding]; other site 1295826004979 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1295826004980 active site 1295826004981 16S rRNA methyltransferase B; Provisional; Region: PRK14902 1295826004982 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 1295826004983 putative RNA binding site [nucleotide binding]; other site 1295826004984 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1295826004985 S-adenosylmethionine binding site [chemical binding]; other site 1295826004986 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 1295826004987 Small integral membrane protein (DUF2273); Region: DUF2273; cl11575 1295826004988 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1295826004989 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1295826004990 putative active site [active] 1295826004991 substrate binding site [chemical binding]; other site 1295826004992 putative cosubstrate binding site; other site 1295826004993 catalytic site [active] 1295826004994 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1295826004995 substrate binding site [chemical binding]; other site 1295826004996 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1295826004997 dimer interface [polypeptide binding]; other site 1295826004998 SnoaL-like domain; Region: SnoaL_2; pfam12680 1295826004999 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 1295826005000 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 1295826005001 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 1295826005002 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1295826005003 ATP binding site [chemical binding]; other site 1295826005004 putative Mg++ binding site [ion binding]; other site 1295826005005 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1295826005006 nucleotide binding region [chemical binding]; other site 1295826005007 ATP-binding site [chemical binding]; other site 1295826005008 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 1295826005009 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1295826005010 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1295826005011 catalytic site [active] 1295826005012 G-X2-G-X-G-K; other site 1295826005013 phosphodiesterase; Provisional; Region: PRK12704 1295826005014 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 1295826005015 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1295826005016 Zn2+ binding site [ion binding]; other site 1295826005017 Mg2+ binding site [ion binding]; other site 1295826005018 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1295826005019 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 1295826005020 active site 1295826005021 trimer interface [polypeptide binding]; other site 1295826005022 allosteric site; other site 1295826005023 active site lid [active] 1295826005024 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1295826005025 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1295826005026 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1295826005027 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1295826005028 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 1295826005029 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1295826005030 S-adenosylmethionine binding site [chemical binding]; other site 1295826005031 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 1295826005032 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 1295826005033 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 1295826005034 Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983 1295826005035 Uncharacterized conserved protein [Function unknown]; Region: COG3595 1295826005036 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 1295826005037 N-acetylmuramoyl-L-alanine amidase; Validated; Region: PRK08581 1295826005038 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 1295826005039 CHAP domain; Region: CHAP; pfam05257 1295826005040 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1295826005041 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1295826005042 intersubunit interface [polypeptide binding]; other site 1295826005043 active site 1295826005044 zinc binding site [ion binding]; other site 1295826005045 Na+ binding site [ion binding]; other site 1295826005046 Predicted membrane protein [Function unknown]; Region: COG2860 1295826005047 UPF0126 domain; Region: UPF0126; pfam03458 1295826005048 UPF0126 domain; Region: UPF0126; pfam03458 1295826005049 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 1295826005050 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 1295826005051 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1295826005052 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1295826005053 active site 1295826005054 dimer interface [polypeptide binding]; other site 1295826005055 motif 1; other site 1295826005056 motif 2; other site 1295826005057 motif 3; other site 1295826005058 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1295826005059 anticodon binding site; other site 1295826005060 ATP cone domain; Region: ATP-cone; pfam03477 1295826005061 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 1295826005062 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1295826005063 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 1295826005064 dimer interface [polypeptide binding]; other site 1295826005065 FMN binding site [chemical binding]; other site 1295826005066 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1295826005067 active site 1295826005068 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1295826005069 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1295826005070 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 1295826005071 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1295826005072 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1295826005073 homodimer interface [polypeptide binding]; other site 1295826005074 catalytic residue [active] 1295826005075 cystathionine gamma-synthase; Reviewed; Region: PRK07269 1295826005076 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1295826005077 homodimer interface [polypeptide binding]; other site 1295826005078 substrate-cofactor binding pocket; other site 1295826005079 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1295826005080 catalytic residue [active] 1295826005081 Homoserine trans-succinylase [Amino acid transport and metabolism]; Region: MetA; COG1897 1295826005082 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 1295826005083 proposed active site lysine [active] 1295826005084 conserved cys residue [active] 1295826005085 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674 1295826005086 nudix motif; other site 1295826005087 Predicted permeases [General function prediction only]; Region: COG0679 1295826005088 Predicted HD-superfamily hydrolase [General function prediction only]; Region: COG3481 1295826005089 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 1295826005090 generic binding surface II; other site 1295826005091 generic binding surface I; other site 1295826005092 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1295826005093 Zn2+ binding site [ion binding]; other site 1295826005094 Mg2+ binding site [ion binding]; other site 1295826005095 Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322 1295826005096 RmuC family; Region: RmuC; pfam02646 1295826005097 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 1295826005098 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1295826005099 substrate binding site [chemical binding]; other site 1295826005100 hexamer interface [polypeptide binding]; other site 1295826005101 metal binding site [ion binding]; metal-binding site 1295826005102 GTPase RsgA; Reviewed; Region: PRK00098 1295826005103 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 1295826005104 RNA binding site [nucleotide binding]; other site 1295826005105 homodimer interface [polypeptide binding]; other site 1295826005106 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1295826005107 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1295826005108 GTP/Mg2+ binding site [chemical binding]; other site 1295826005109 G4 box; other site 1295826005110 G1 box; other site 1295826005111 Switch I region; other site 1295826005112 G2 box; other site 1295826005113 G3 box; other site 1295826005114 Switch II region; other site 1295826005115 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 1295826005116 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 1295826005117 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1295826005118 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1295826005119 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1295826005120 dimer interface [polypeptide binding]; other site 1295826005121 motif 1; other site 1295826005122 active site 1295826005123 motif 2; other site 1295826005124 motif 3; other site 1295826005125 Phenolic acid decarboxylase (PAD); Region: PA_decarbox; cl01382 1295826005126 Predicted transcriptional regulators [Transcription]; Region: COG1695 1295826005127 Transcriptional regulator PadR-like family; Region: PadR; cl17335 1295826005128 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 1295826005129 GH18 domain of Chitinase D (ChiD). ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins. The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871 1295826005130 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 1295826005131 putative active site [active] 1295826005132 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 1295826005133 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1295826005134 Interdomain contacts; other site 1295826005135 Cytokine receptor motif; other site 1295826005136 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 1295826005137 aromatic chitin/cellulose binding site residues [chemical binding]; other site 1295826005138 Chitin binding domain; Region: Chitin_bind_3; pfam03067 1295826005139 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1295826005140 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1295826005141 GDP-binding site [chemical binding]; other site 1295826005142 ACT binding site; other site 1295826005143 IMP binding site; other site 1295826005144 Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300 1295826005145 Cadmium resistance transporter; Region: Cad; pfam03596 1295826005146 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 1295826005147 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 1295826005148 dimerization interface [polypeptide binding]; other site 1295826005149 domain crossover interface; other site 1295826005150 redox-dependent activation switch; other site 1295826005151 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1295826005152 RibD C-terminal domain; Region: RibD_C; cl17279 1295826005153 Protein of unknown function (DUF805); Region: DUF805; pfam05656 1295826005154 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 1295826005155 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1295826005156 FMN binding site [chemical binding]; other site 1295826005157 active site 1295826005158 catalytic residues [active] 1295826005159 substrate binding site [chemical binding]; other site 1295826005160 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1295826005161 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1295826005162 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1295826005163 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1295826005164 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1295826005165 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1295826005166 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1295826005167 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1295826005168 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1295826005169 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1295826005170 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1295826005171 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1295826005172 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1295826005173 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1295826005174 dimer interface [polypeptide binding]; other site 1295826005175 anticodon binding site; other site 1295826005176 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1295826005177 homodimer interface [polypeptide binding]; other site 1295826005178 motif 1; other site 1295826005179 active site 1295826005180 motif 2; other site 1295826005181 GAD domain; Region: GAD; pfam02938 1295826005182 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1295826005183 active site 1295826005184 motif 3; other site 1295826005185 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 1295826005186 nucleotide binding site/active site [active] 1295826005187 HIT family signature motif; other site 1295826005188 catalytic residue [active] 1295826005189 histidyl-tRNA synthetase; Region: hisS; TIGR00442 1295826005190 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1295826005191 dimer interface [polypeptide binding]; other site 1295826005192 motif 1; other site 1295826005193 active site 1295826005194 motif 2; other site 1295826005195 motif 3; other site 1295826005196 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1295826005197 anticodon binding site; other site 1295826005198 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1295826005199 non-specific DNA binding site [nucleotide binding]; other site 1295826005200 salt bridge; other site 1295826005201 sequence-specific DNA binding site [nucleotide binding]; other site 1295826005202 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 1295826005203 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 1295826005204 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1295826005205 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1295826005206 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1295826005207 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1295826005208 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1295826005209 recF protein; Region: recf; TIGR00611 1295826005210 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 1295826005211 Walker A/P-loop; other site 1295826005212 ATP binding site [chemical binding]; other site 1295826005213 Q-loop/lid; other site 1295826005214 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1295826005215 ABC transporter signature motif; other site 1295826005216 Walker B; other site 1295826005217 D-loop; other site 1295826005218 H-loop/switch region; other site 1295826005219 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1295826005220 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 1295826005221 DNA binding residues [nucleotide binding] 1295826005222 putative dimer interface [polypeptide binding]; other site 1295826005223 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 1295826005224 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 1295826005225 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 1295826005226 NAD binding site [chemical binding]; other site 1295826005227 homodimer interface [polypeptide binding]; other site 1295826005228 active site 1295826005229 substrate binding site [chemical binding]; other site 1295826005230 galactose-1-phosphate uridylyltransferase, family 2; Region: galT_2; TIGR01239 1295826005231 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 1295826005232 Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744 1295826005233 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 1295826005234 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1295826005235 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1295826005236 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1295826005237 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1295826005238 putative active site [active] 1295826005239 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1295826005240 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1295826005241 active site 1295826005242 catalytic tetrad [active] 1295826005243 nicotinamide-nucleotide adenylyltransferase, NadR type; Region: nadR_NMN_Atrans; TIGR01526 1295826005244 Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional NadR-like proteins; Region: NMNAT_NadR; cd02167 1295826005245 active site 1295826005246 (T/H)XGH motif; other site 1295826005247 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 1295826005248 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1295826005249 Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300 1295826005250 NAD binding site [chemical binding]; other site 1295826005251 ligand binding site [chemical binding]; other site 1295826005252 catalytic site [active] 1295826005253 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1295826005254 Peptidase family U32; Region: Peptidase_U32; pfam01136 1295826005255 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 1295826005256 Methyltransferase domain; Region: Methyltransf_11; pfam08241 1295826005257 CutC family; Region: CutC; pfam03932 1295826005258 Predicted ABC-type exoprotein transport system, permease component [Intracellular trafficking and secretion]; Region: EcsB; COG4473 1295826005259 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1295826005260 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1295826005261 Walker A/P-loop; other site 1295826005262 ATP binding site [chemical binding]; other site 1295826005263 Q-loop/lid; other site 1295826005264 ABC transporter signature motif; other site 1295826005265 Walker B; other site 1295826005266 D-loop; other site 1295826005267 H-loop/switch region; other site 1295826005268 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; cl01974 1295826005269 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1295826005270 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 1295826005271 putative active site [active] 1295826005272 catalytic site [active] 1295826005273 putative metal binding site [ion binding]; other site 1295826005274 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1295826005275 mRNA/rRNA interface [nucleotide binding]; other site 1295826005276 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1295826005277 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1295826005278 23S rRNA interface [nucleotide binding]; other site 1295826005279 L7/L12 interface [polypeptide binding]; other site 1295826005280 putative thiostrepton binding site; other site 1295826005281 L25 interface [polypeptide binding]; other site 1295826005282 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1295826005283 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1295826005284 Walker A/P-loop; other site 1295826005285 ATP binding site [chemical binding]; other site 1295826005286 Q-loop/lid; other site 1295826005287 ABC transporter signature motif; other site 1295826005288 Walker B; other site 1295826005289 D-loop; other site 1295826005290 H-loop/switch region; other site 1295826005291 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4479 1295826005292 methionine sulfoxide reductase A; Provisional; Region: PRK14054 1295826005293 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 1295826005294 S1 domain; Region: S1_2; pfam13509 1295826005295 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1295826005296 RNA binding site [nucleotide binding]; other site 1295826005297 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 1295826005298 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1295826005299 Coenzyme A binding pocket [chemical binding]; other site 1295826005300 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1295826005301 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1295826005302 hinge region; other site 1295826005303 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1295826005304 putative nucleotide binding site [chemical binding]; other site 1295826005305 uridine monophosphate binding site [chemical binding]; other site 1295826005306 homohexameric interface [polypeptide binding]; other site 1295826005307 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 1295826005308 propionate/acetate kinase; Provisional; Region: PRK12379 1295826005309 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 1295826005310 propionate/acetate kinase; Provisional; Region: PRK12379 1295826005311 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 1295826005312 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1295826005313 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 1295826005314 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1295826005315 G1 box; other site 1295826005316 putative GEF interaction site [polypeptide binding]; other site 1295826005317 GTP/Mg2+ binding site [chemical binding]; other site 1295826005318 Switch I region; other site 1295826005319 G2 box; other site 1295826005320 G3 box; other site 1295826005321 Switch II region; other site 1295826005322 G4 box; other site 1295826005323 G5 box; other site 1295826005324 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1295826005325 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1295826005326 LytTr DNA-binding domain; Region: LytTR; cl04498 1295826005327 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4483 1295826005328 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 1295826005329 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1295826005330 nucleotide binding site [chemical binding]; other site 1295826005331 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1295826005332 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1295826005333 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1295826005334 dimerization interface [polypeptide binding]; other site 1295826005335 DPS ferroxidase diiron center [ion binding]; other site 1295826005336 ion pore; other site 1295826005337 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 1295826005338 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 1295826005339 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1295826005340 active site 1295826005341 DNA polymerase IV; Validated; Region: PRK02406 1295826005342 DNA binding site [nucleotide binding] 1295826005343 This CD includes bacterial (Agrobacterium tumefaciens and Caulobacter crescentus ProX, and Clostridium sticklandii PrdX) and eukaryotic (Plasmodium falciparum N-terminal ProRS editing domain) sequences. The C. sticklandii PrdX protein, a homolog of the...; Region: PrdX_deacylase; cd04335 1295826005344 putative deacylase active site [active] 1295826005345 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 1295826005346 carbamate kinase; Reviewed; Region: PRK12686 1295826005347 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 1295826005348 putative substrate binding site [chemical binding]; other site 1295826005349 nucleotide binding site [chemical binding]; other site 1295826005350 nucleotide binding site [chemical binding]; other site 1295826005351 homodimer interface [polypeptide binding]; other site 1295826005352 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 1295826005353 ornithine carbamoyltransferase; Validated; Region: PRK02102 1295826005354 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1295826005355 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1295826005356 arginine deiminase; Provisional; Region: PRK01388 1295826005357 arginyl-tRNA synthetase; Reviewed; Region: PRK12451 1295826005358 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 1295826005359 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1295826005360 active site 1295826005361 HIGH motif; other site 1295826005362 KMSK motif region; other site 1295826005363 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 1295826005364 tRNA binding surface [nucleotide binding]; other site 1295826005365 anticodon binding site; other site 1295826005366 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1295826005367 arginine repressor; Region: argR_whole; TIGR01529 1295826005368 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1295826005369 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1295826005370 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1295826005371 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1295826005372 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1295826005373 SWIM zinc finger; Region: SWIM; pfam04434 1295826005374 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 1295826005375 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 1295826005376 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1295826005377 ATP binding site [chemical binding]; other site 1295826005378 putative Mg++ binding site [ion binding]; other site 1295826005379 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1295826005380 nucleotide binding region [chemical binding]; other site 1295826005381 ATP-binding site [chemical binding]; other site 1295826005382 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1295826005383 metal ion-dependent adhesion site (MIDAS); other site 1295826005384 pyruvate oxidase; Region: pyruv_oxi_spxB; TIGR02720 1295826005385 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 1295826005386 PYR/PP interface [polypeptide binding]; other site 1295826005387 dimer interface [polypeptide binding]; other site 1295826005388 tetramer interface [polypeptide binding]; other site 1295826005389 TPP binding site [chemical binding]; other site 1295826005390 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1295826005391 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 1295826005392 TPP-binding site [chemical binding]; other site 1295826005393 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 1295826005394 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1295826005395 CAAX protease self-immunity; Region: Abi; pfam02517 1295826005396 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 1295826005397 amphipathic channel; other site 1295826005398 Asn-Pro-Ala signature motifs; other site 1295826005399 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 1295826005400 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 1295826005401 catalytic triad [active] 1295826005402 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1295826005403 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1295826005404 substrate binding pocket [chemical binding]; other site 1295826005405 membrane-bound complex binding site; other site 1295826005406 hinge residues; other site 1295826005407 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK07251 1295826005408 TrkA-N domain; Region: TrkA_N; pfam02254 1295826005409 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1295826005410 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1295826005411 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 1295826005412 Isochorismatase family; Region: Isochorismatase; pfam00857 1295826005413 catalytic triad [active] 1295826005414 conserved cis-peptide bond; other site 1295826005415 Isochorismatase family; Region: Isochorismatase; pfam00857 1295826005416 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 1295826005417 catalytic triad [active] 1295826005418 conserved cis-peptide bond; other site 1295826005419 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1295826005420 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1295826005421 PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396 1295826005422 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1295826005423 active site 1295826005424 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1295826005425 DNA-binding ferritin-like protein (Dps family) [General function prediction only]; Region: COG4817 1295826005426 Protein of unknown function (DUF1048); Region: DUF1048; pfam06304 1295826005427 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 1295826005428 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 1295826005429 putative active site [active] 1295826005430 Predicted membrane protein [Function unknown]; Region: COG3619 1295826005431 DNA repair protein RadA; Provisional; Region: PRK11823 1295826005432 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 1295826005433 Walker A motif/ATP binding site; other site 1295826005434 ATP binding site [chemical binding]; other site 1295826005435 Walker B motif; other site 1295826005436 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1295826005437 histidinol-phosphate phosphatase family domain; Region: Histidinol-ppas; TIGR01656 1295826005438 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1295826005439 active site 1295826005440 motif I; other site 1295826005441 motif II; other site 1295826005442 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1295826005443 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 1295826005444 dimer interface [polypeptide binding]; other site 1295826005445 active site 1295826005446 Predicted kinase related to galactokinase and mevalonate kinase [General function prediction only]; Region: COG2605 1295826005447 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1295826005448 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1295826005449 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1295826005450 active site 1295826005451 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1295826005452 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1295826005453 active site 1295826005454 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1295826005455 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1295826005456 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1295826005457 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1295826005458 alphaNTD homodimer interface [polypeptide binding]; other site 1295826005459 alphaNTD - beta interaction site [polypeptide binding]; other site 1295826005460 alphaNTD - beta' interaction site [polypeptide binding]; other site 1295826005461 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1295826005462 30S ribosomal protein S11; Validated; Region: PRK05309 1295826005463 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 1295826005464 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1295826005465 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 1295826005466 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1295826005467 rRNA binding site [nucleotide binding]; other site 1295826005468 predicted 30S ribosome binding site; other site 1295826005469 adenylate kinase; Reviewed; Region: adk; PRK00279 1295826005470 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1295826005471 AMP-binding site [chemical binding]; other site 1295826005472 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1295826005473 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1295826005474 SecY translocase; Region: SecY; pfam00344 1295826005475 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1295826005476 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1295826005477 23S rRNA binding site [nucleotide binding]; other site 1295826005478 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1295826005479 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1295826005480 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1295826005481 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1295826005482 5S rRNA interface [nucleotide binding]; other site 1295826005483 L27 interface [polypeptide binding]; other site 1295826005484 23S rRNA interface [nucleotide binding]; other site 1295826005485 L5 interface [polypeptide binding]; other site 1295826005486 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1295826005487 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1295826005488 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1295826005489 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1295826005490 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 1295826005491 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1295826005492 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1295826005493 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1295826005494 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1295826005495 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1295826005496 RNA binding site [nucleotide binding]; other site 1295826005497 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1295826005498 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1295826005499 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1295826005500 23S rRNA interface [nucleotide binding]; other site 1295826005501 putative translocon interaction site; other site 1295826005502 signal recognition particle (SRP54) interaction site; other site 1295826005503 L23 interface [polypeptide binding]; other site 1295826005504 trigger factor interaction site; other site 1295826005505 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1295826005506 23S rRNA interface [nucleotide binding]; other site 1295826005507 5S rRNA interface [nucleotide binding]; other site 1295826005508 putative antibiotic binding site [chemical binding]; other site 1295826005509 L25 interface [polypeptide binding]; other site 1295826005510 L27 interface [polypeptide binding]; other site 1295826005511 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1295826005512 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1295826005513 G-X-X-G motif; other site 1295826005514 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1295826005515 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1295826005516 putative translocon binding site; other site 1295826005517 protein-rRNA interface [nucleotide binding]; other site 1295826005518 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1295826005519 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1295826005520 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1295826005521 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1295826005522 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1295826005523 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1295826005524 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 1295826005525 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1295826005526 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1295826005527 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 1295826005528 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 1295826005529 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 1295826005530 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1295826005531 catalytic residue [active] 1295826005532 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1295826005533 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1295826005534 putative homodimer interface [polypeptide binding]; other site 1295826005535 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1295826005536 heterodimer interface [polypeptide binding]; other site 1295826005537 homodimer interface [polypeptide binding]; other site 1295826005538 Preprotein translocase subunit SecE [Intracellular trafficking and secretion]; Region: SecE; COG0690 1295826005539 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 1295826005540 Transglycosylase; Region: Transgly; pfam00912 1295826005541 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1295826005542 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1295826005543 Predicted membrane protein [Function unknown]; Region: COG2323 1295826005544 Protein of unknown function (DUF3290); Region: DUF3290; pfam11694 1295826005545 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1295826005546 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1295826005547 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1295826005548 active site 1295826005549 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1295826005550 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1295826005551 ABC-ATPase subunit interface; other site 1295826005552 dimer interface [polypeptide binding]; other site 1295826005553 putative PBP binding regions; other site 1295826005554 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1295826005555 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1295826005556 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 1295826005557 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 1295826005558 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 1295826005559 metal binding site [ion binding]; metal-binding site 1295826005560 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1295826005561 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1295826005562 putative DNA binding site [nucleotide binding]; other site 1295826005563 putative Zn2+ binding site [ion binding]; other site 1295826005564 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 1295826005565 Type II secretory pathway pseudopilin; Region: PulG; pfam11773 1295826005566 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 1295826005567 Type II/IV secretion system protein; Region: T2SE; pfam00437 1295826005568 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1295826005569 Walker A motif; other site 1295826005570 ATP binding site [chemical binding]; other site 1295826005571 Walker B motif; other site 1295826005572 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 1295826005573 DNA polymerase III, alpha subunit (gram-positive type) [DNA replication, recombination, and repair]; Region: PolC; COG2176 1295826005574 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 1295826005575 generic binding surface II; other site 1295826005576 generic binding surface I; other site 1295826005577 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 1295826005578 generic binding surface II; other site 1295826005579 generic binding surface I; other site 1295826005580 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 1295826005581 active site 1295826005582 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1295826005583 active site 1295826005584 catalytic site [active] 1295826005585 substrate binding site [chemical binding]; other site 1295826005586 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 1295826005587 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 1295826005588 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1295826005589 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1295826005590 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1295826005591 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1295826005592 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 1295826005593 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14830 1295826005594 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 1295826005595 catalytic residue [active] 1295826005596 putative FPP diphosphate binding site; other site 1295826005597 putative FPP binding hydrophobic cleft; other site 1295826005598 dimer interface [polypeptide binding]; other site 1295826005599 putative IPP diphosphate binding site; other site 1295826005600 Preprotein translocase subunit; Region: YajC; cl00806 1295826005601 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 1295826005602 A new structural DNA glycosylase containing HEAT-like repeats; Region: AlkD_like_1; cd07064 1295826005603 active site 1295826005604 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 1295826005605 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1295826005606 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1295826005607 protein binding site [polypeptide binding]; other site 1295826005608 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1295826005609 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1295826005610 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1295826005611 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 1295826005612 putative ADP-binding pocket [chemical binding]; other site 1295826005613 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4703 1295826005614 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 1295826005615 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1295826005616 S-adenosylmethionine binding site [chemical binding]; other site 1295826005617 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1295826005618 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1295826005619 DNA binding site [nucleotide binding] 1295826005620 domain linker motif; other site 1295826005621 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1295826005622 Negative regulator of septation ring formation [Cell division and chromosome partitioning]; Region: EzrA; COG4477 1295826005623 elongation factor Ts; Provisional; Region: tsf; PRK09377 1295826005624 UBA/TS-N domain; Region: UBA; pfam00627 1295826005625 Elongation factor TS; Region: EF_TS; pfam00889 1295826005626 Elongation factor TS; Region: EF_TS; pfam00889 1295826005627 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1295826005628 rRNA interaction site [nucleotide binding]; other site 1295826005629 S8 interaction site; other site 1295826005630 putative laminin-1 binding site; other site 1295826005631 3-carboxymuconate cyclase [Carbohydrate transport and metabolism]; Region: COG2706 1295826005632 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1295826005633 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1295826005634 putative heme d1 biosynthesis radical SAM protein NirJ2; Region: rSAM_NirJ2; TIGR04055 1295826005635 FeS/SAM binding site; other site 1295826005636 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1295826005637 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1295826005638 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1295826005639 putative substrate translocation pore; other site 1295826005640 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1295826005641 Radical SAM superfamily; Region: Radical_SAM; pfam04055 1295826005642 FeS/SAM binding site; other site 1295826005643 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1295826005644 KxxxW cyclic peptide radical SAM maturase; Region: rSAM_pep_cyc; TIGR04080 1295826005645 KxxxW-cyclized secreted peptide; Region: phero_cyc_pep; TIGR04079 1295826005646 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 1295826005647 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 1295826005648 protein binding site [polypeptide binding]; other site 1295826005649 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1295826005650 Phosphopantetheine adenylyltransferase [Coenzyme metabolism]; Region: CoaD; COG0669 1295826005651 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1295826005652 active site 1295826005653 (T/H)XGH motif; other site 1295826005654 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 1295826005655 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1295826005656 S-adenosylmethionine binding site [chemical binding]; other site 1295826005657 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1295826005658 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1295826005659 putative substrate translocation pore; other site 1295826005660 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1295826005661 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1295826005662 putative substrate translocation pore; other site 1295826005663 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 1295826005664 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1295826005665 active site 1295826005666 dimer interface [polypeptide binding]; other site 1295826005667 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1295826005668 dimer interface [polypeptide binding]; other site 1295826005669 active site 1295826005670 Flagellin N-methylase; Region: FliB; pfam03692 1295826005671 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 1295826005672 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1295826005673 NAD(P) binding site [chemical binding]; other site 1295826005674 active site 1295826005675 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1295826005676 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1295826005677 NAD(P) binding site [chemical binding]; other site 1295826005678 active site 1295826005679 Predicted transcriptional regulators [Transcription]; Region: COG1733 1295826005680 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1295826005681 putative DNA binding site [nucleotide binding]; other site 1295826005682 dimerization interface [polypeptide binding]; other site 1295826005683 putative Zn2+ binding site [ion binding]; other site 1295826005684 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1295826005685 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1295826005686 active site 1295826005687 HIGH motif; other site 1295826005688 nucleotide binding site [chemical binding]; other site 1295826005689 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1295826005690 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1295826005691 active site 1295826005692 KMSKS motif; other site 1295826005693 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1295826005694 tRNA binding surface [nucleotide binding]; other site 1295826005695 anticodon binding site; other site 1295826005696 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1295826005697 Fibronectin-binding protein (FBP); Region: FBP; pfam07299 1295826005698 Domain of unknown function (DUF1912); Region: DUF1912; pfam08930 1295826005699 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 1295826005700 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 1295826005701 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1295826005702 Coenzyme A binding pocket [chemical binding]; other site 1295826005703 TRAM domain; Region: TRAM; pfam01938 1295826005704 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 1295826005705 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1295826005706 S-adenosylmethionine binding site [chemical binding]; other site 1295826005707 legume lectins; Region: lectin_L-type; cd01951 1295826005708 homotetramer interaction site [polypeptide binding]; other site 1295826005709 carbohydrate binding site [chemical binding]; other site 1295826005710 metal binding site [ion binding]; metal-binding site 1295826005711 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1295826005712 MucBP domain; Region: MucBP; pfam06458 1295826005713 MucBP domain; Region: MucBP; pfam06458 1295826005714 MucBP domain; Region: MucBP; pfam06458 1295826005715 recombination regulator RecX; Provisional; Region: recX; PRK14135 1295826005716 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 1295826005717 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 1295826005718 N- and C-terminal domain interface [polypeptide binding]; other site 1295826005719 active site 1295826005720 catalytic site [active] 1295826005721 metal binding site [ion binding]; metal-binding site 1295826005722 carbohydrate binding site [chemical binding]; other site 1295826005723 ATP binding site [chemical binding]; other site 1295826005724 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 1295826005725 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1295826005726 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1295826005727 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1295826005728 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1295826005729 putative active site [active] 1295826005730 Staphylococcal protein of unknown function (DUF960); Region: DUF960; pfam06124 1295826005731 phosphodiesterase YaeI; Provisional; Region: PRK11340 1295826005732 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1295826005733 putative active site [active] 1295826005734 putative metal binding site [ion binding]; other site 1295826005735 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 1295826005736 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1295826005737 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1295826005738 dimer interface [polypeptide binding]; other site 1295826005739 ssDNA binding site [nucleotide binding]; other site 1295826005740 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1295826005741 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1295826005742 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 1295826005743 Amino acid transporters [Amino acid transport and metabolism]; Region: LysP; COG0833 1295826005744 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 1295826005745 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1295826005746 Walker A motif; other site 1295826005747 ATP binding site [chemical binding]; other site 1295826005748 Walker B motif; other site 1295826005749 arginine finger; other site 1295826005750 Phosphotransferase enzyme family; Region: APH; pfam01636 1295826005751 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1295826005752 substrate binding site [chemical binding]; other site 1295826005753 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 1295826005754 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1295826005755 hypothetical protein; Provisional; Region: PRK07248 1295826005756 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1295826005757 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1295826005758 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1295826005759 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1295826005760 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1295826005761 DNA binding residues [nucleotide binding] 1295826005762 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1295826005763 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1295826005764 active site 1295826005765 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1295826005766 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1295826005767 Walker A motif; other site 1295826005768 ATP binding site [chemical binding]; other site 1295826005769 Walker B motif; other site 1295826005770 arginine finger; other site 1295826005771 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1295826005772 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 1295826005773 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1295826005774 ATP binding site [chemical binding]; other site 1295826005775 Mg2+ binding site [ion binding]; other site 1295826005776 G-X-G motif; other site 1295826005777 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 1295826005778 ATP binding site [chemical binding]; other site 1295826005779 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 1295826005780 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 1295826005781 MutS domain I; Region: MutS_I; pfam01624 1295826005782 MutS domain II; Region: MutS_II; pfam05188 1295826005783 MutS domain III; Region: MutS_III; pfam05192 1295826005784 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 1295826005785 Walker A/P-loop; other site 1295826005786 ATP binding site [chemical binding]; other site 1295826005787 Q-loop/lid; other site 1295826005788 ABC transporter signature motif; other site 1295826005789 Walker B; other site 1295826005790 D-loop; other site 1295826005791 H-loop/switch region; other site 1295826005792 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1295826005793 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1295826005794 Protein of unknown function (DUF1634); Region: DUF1634; cl01741 1295826005795 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1295826005796 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1295826005797 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1295826005798 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1295826005799 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 1295826005800 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1295826005801 active site 1295826005802 motif I; other site 1295826005803 motif II; other site 1295826005804 chaperone protein DnaJ; Provisional; Region: PRK14276 1295826005805 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1295826005806 HSP70 interaction site [polypeptide binding]; other site 1295826005807 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 1295826005808 substrate binding site [polypeptide binding]; other site 1295826005809 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1295826005810 Zn binding sites [ion binding]; other site 1295826005811 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1295826005812 substrate binding site [polypeptide binding]; other site 1295826005813 dimer interface [polypeptide binding]; other site 1295826005814 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4990 1295826005815 aspartate racemase; Region: asp_race; TIGR00035 1295826005816 Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794 1295826005817 Predicted ATP-grasp enzyme [General function prediction only]; Region: COG3919 1295826005818 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 1295826005819 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 1295826005820 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1295826005821 active site 1295826005822 dimer interface [polypeptide binding]; other site 1295826005823 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1295826005824 Ligand Binding Site [chemical binding]; other site 1295826005825 Molecular Tunnel; other site 1295826005826 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 1295826005827 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1295826005828 Surface antigen [General function prediction only]; Region: COG3942 1295826005829 CHAP domain; Region: CHAP; pfam05257 1295826005830 rod shape-determining protein MreD; Region: MreD; pfam04093 1295826005831 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreC; COG1792 1295826005832 rod shape-determining protein MreC; Region: MreC; pfam04085 1295826005833 LXG domain of WXG superfamily; Region: LXG; pfam04740 1295826005834 Protein of unknown function DUF262; Region: DUF262; pfam03235 1295826005835 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 1295826005836 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1295826005837 cofactor binding site; other site 1295826005838 DNA binding site [nucleotide binding] 1295826005839 substrate interaction site [chemical binding]; other site 1295826005840 Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684 1295826005841 nudix motif; other site 1295826005842 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 1295826005843 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1295826005844 active site 1295826005845 dimer interface [polypeptide binding]; other site 1295826005846 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1295826005847 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1295826005848 ligand binding site [chemical binding]; other site 1295826005849 flexible hinge region; other site 1295826005850 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1295826005851 putative switch regulator; other site 1295826005852 non-specific DNA interactions [nucleotide binding]; other site 1295826005853 DNA binding site [nucleotide binding] 1295826005854 sequence specific DNA binding site [nucleotide binding]; other site 1295826005855 putative cAMP binding site [chemical binding]; other site 1295826005856 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1295826005857 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1295826005858 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1295826005859 Ligand Binding Site [chemical binding]; other site 1295826005860 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1295826005861 nucleotide binding site [chemical binding]; other site 1295826005862 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 1295826005863 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 1295826005864 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3580 1295826005865 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 1295826005866 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 1295826005867 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1295826005868 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1295826005869 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1295826005870 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1295826005871 RNA binding surface [nucleotide binding]; other site 1295826005872 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 1295826005873 active site 1295826005874 uracil binding [chemical binding]; other site 1295826005875 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1295826005876 active site 1295826005877 ATP binding site [chemical binding]; other site 1295826005878 substrate binding site [chemical binding]; other site 1295826005879 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 1295826005880 activation loop (A-loop); other site 1295826005881 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 1295826005882 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1295826005883 non-specific DNA binding site [nucleotide binding]; other site 1295826005884 salt bridge; other site 1295826005885 sequence-specific DNA binding site [nucleotide binding]; other site 1295826005886 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 1295826005887 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1295826005888 generic binding surface II; other site 1295826005889 ssDNA binding site; other site 1295826005890 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1295826005891 ATP binding site [chemical binding]; other site 1295826005892 putative Mg++ binding site [ion binding]; other site 1295826005893 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1295826005894 nucleotide binding region [chemical binding]; other site 1295826005895 ATP-binding site [chemical binding]; other site 1295826005896 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 1295826005897 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 1295826005898 PhnA protein; Region: PhnA; pfam03831 1295826005899 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 1295826005900 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1295826005901 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1295826005902 seryl-tRNA synthetase; Region: serS; TIGR00414 1295826005903 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 1295826005904 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1295826005905 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1295826005906 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1295826005907 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1295826005908 motif II; other site 1295826005909 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1295826005910 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1295826005911 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1295826005912 oxidoreductase; Provisional; Region: PRK06196 1295826005913 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1295826005914 NAD(P) binding site [chemical binding]; other site 1295826005915 active site 1295826005916 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1295826005917 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1295826005918 23S rRNA interface [nucleotide binding]; other site 1295826005919 L3 interface [polypeptide binding]; other site 1295826005920 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1295826005921 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1295826005922 FtsX-like permease family; Region: FtsX; pfam02687 1295826005923 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1295826005924 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1295826005925 Walker A/P-loop; other site 1295826005926 ATP binding site [chemical binding]; other site 1295826005927 Q-loop/lid; other site 1295826005928 ABC transporter signature motif; other site 1295826005929 Walker B; other site 1295826005930 D-loop; other site 1295826005931 H-loop/switch region; other site 1295826005932 ribonuclease HIII; Provisional; Region: PRK00996 1295826005933 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 1295826005934 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 1295826005935 RNA/DNA hybrid binding site [nucleotide binding]; other site 1295826005936 active site 1295826005937 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1295826005938 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1295826005939 Catalytic site [active] 1295826005940 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1295826005941 pur operon repressor; Provisional; Region: PRK09213 1295826005942 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 1295826005943 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1295826005944 active site 1295826005945 elongation factor G; Reviewed; Region: PRK00007 1295826005946 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1295826005947 G1 box; other site 1295826005948 putative GEF interaction site [polypeptide binding]; other site 1295826005949 GTP/Mg2+ binding site [chemical binding]; other site 1295826005950 Switch I region; other site 1295826005951 G2 box; other site 1295826005952 G3 box; other site 1295826005953 Switch II region; other site 1295826005954 G4 box; other site 1295826005955 G5 box; other site 1295826005956 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1295826005957 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1295826005958 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1295826005959 30S ribosomal protein S7; Validated; Region: PRK05302 1295826005960 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1295826005961 S17 interaction site [polypeptide binding]; other site 1295826005962 S8 interaction site; other site 1295826005963 16S rRNA interaction site [nucleotide binding]; other site 1295826005964 streptomycin interaction site [chemical binding]; other site 1295826005965 23S rRNA interaction site [nucleotide binding]; other site 1295826005966 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1295826005967 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 1295826005968 Beta-lactamase; Region: Beta-lactamase; cl17358 1295826005969 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 1295826005970 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 1295826005971 Putative rRNA methylase; Region: rRNA_methylase; pfam06962 1295826005972 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242