-- dump date 20140619_123217 -- class Genbank::misc_feature -- table misc_feature_note -- id note 390333000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 390333000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 390333000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 390333000004 Walker A motif; other site 390333000005 ATP binding site [chemical binding]; other site 390333000006 Walker B motif; other site 390333000007 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 390333000008 arginine finger; other site 390333000009 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 390333000010 DnaA box-binding interface [nucleotide binding]; other site 390333000011 DNA polymerase III subunit beta; Validated; Region: PRK05643 390333000012 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 390333000013 putative DNA binding surface [nucleotide binding]; other site 390333000014 dimer interface [polypeptide binding]; other site 390333000015 beta-clamp/clamp loader binding surface; other site 390333000016 beta-clamp/translesion DNA polymerase binding surface; other site 390333000017 S4 domain; Region: S4_2; pfam13275 390333000018 recombination protein F; Reviewed; Region: recF; PRK00064 390333000019 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 390333000020 Walker A/P-loop; other site 390333000021 ATP binding site [chemical binding]; other site 390333000022 Q-loop/lid; other site 390333000023 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 390333000024 ABC transporter signature motif; other site 390333000025 Walker B; other site 390333000026 D-loop; other site 390333000027 H-loop/switch region; other site 390333000028 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 390333000029 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 390333000030 Mg2+ binding site [ion binding]; other site 390333000031 G-X-G motif; other site 390333000032 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 390333000033 anchoring element; other site 390333000034 dimer interface [polypeptide binding]; other site 390333000035 ATP binding site [chemical binding]; other site 390333000036 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 390333000037 active site 390333000038 putative metal-binding site [ion binding]; other site 390333000039 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 390333000040 DNA gyrase subunit A; Validated; Region: PRK05560 390333000041 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 390333000042 CAP-like domain; other site 390333000043 active site 390333000044 primary dimer interface [polypeptide binding]; other site 390333000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 390333000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 390333000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 390333000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 390333000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 390333000050 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 390333000051 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 390333000052 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 390333000053 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 390333000054 dimer interface [polypeptide binding]; other site 390333000055 ssDNA binding site [nucleotide binding]; other site 390333000056 tetramer (dimer of dimers) interface [polypeptide binding]; other site 390333000057 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 390333000058 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 390333000059 DHH family; Region: DHH; pfam01368 390333000060 DHHA1 domain; Region: DHHA1; pfam02272 390333000061 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 390333000062 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 390333000063 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 390333000064 replicative DNA helicase; Region: DnaB; TIGR00665 390333000065 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 390333000066 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 390333000067 Walker A motif; other site 390333000068 ATP binding site [chemical binding]; other site 390333000069 Walker B motif; other site 390333000070 DNA binding loops [nucleotide binding] 390333000071 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cd00741 390333000072 nucleophilic elbow; other site 390333000073 catalytic triad; other site 390333000074 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 390333000075 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 390333000076 Walker A/P-loop; other site 390333000077 ATP binding site [chemical binding]; other site 390333000078 Q-loop/lid; other site 390333000079 ABC transporter signature motif; other site 390333000080 Walker B; other site 390333000081 D-loop; other site 390333000082 H-loop/switch region; other site 390333000083 FtsX-like permease family; Region: FtsX; pfam02687 390333000084 putative Mg(2+) transport ATPase; Provisional; Region: PRK09977 390333000085 MgtC family; Region: MgtC; pfam02308 390333000086 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 390333000087 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 390333000088 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 390333000089 Walker A/P-loop; other site 390333000090 ATP binding site [chemical binding]; other site 390333000091 Q-loop/lid; other site 390333000092 ABC transporter signature motif; other site 390333000093 Walker B; other site 390333000094 D-loop; other site 390333000095 H-loop/switch region; other site 390333000096 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 390333000097 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 390333000098 active site 390333000099 phosphorylation site [posttranslational modification] 390333000100 intermolecular recognition site; other site 390333000101 dimerization interface [polypeptide binding]; other site 390333000102 LytTr DNA-binding domain; Region: LytTR; pfam04397 390333000103 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 390333000104 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 390333000105 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 390333000106 Walker A/P-loop; other site 390333000107 ATP binding site [chemical binding]; other site 390333000108 Q-loop/lid; other site 390333000109 ABC transporter signature motif; other site 390333000110 Walker B; other site 390333000111 D-loop; other site 390333000112 H-loop/switch region; other site 390333000113 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 390333000114 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 390333000115 active site 390333000116 ATP binding site [chemical binding]; other site 390333000117 substrate binding site [chemical binding]; other site 390333000118 activation loop (A-loop); other site 390333000119 Lanthionine synthetase C-like domain associated with serine threonine kinases. Some members of this subgroup lack the zinc binding site and the active site residues, and therefore are most likely inactive. The function of this domain is unknown; Region: LanC_SerThrkinase; cd04791 390333000120 active site 390333000121 zinc binding site [ion binding]; other site 390333000122 putative ABC transporter ATP-binding protein YbbL; Provisional; Region: PRK10247 390333000123 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 390333000124 Walker A/P-loop; other site 390333000125 ATP binding site [chemical binding]; other site 390333000126 Q-loop/lid; other site 390333000127 ABC transporter signature motif; other site 390333000128 Walker B; other site 390333000129 D-loop; other site 390333000130 H-loop/switch region; other site 390333000131 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 390333000132 Cpl-1 lysin (also known as Cpl-9 lysozyme / muramidase) is a bacterial cell wall endolysin encoded by the pneumococcal bacteriophage Cp-1, which cleaves the glycosidic N-acetylmuramoyl-(beta1,4)-N-acetylglucosamine bonds of the pneumococcal glycan chain; Region: GH25_Cpl1-like; cd06415 390333000133 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 390333000134 active site 390333000135 Bacterial surface layer protein; Region: SLAP; pfam03217 390333000136 Bacterial surface layer protein; Region: SLAP; pfam03217 390333000137 Bacterial surface layer protein; Region: SLAP; pfam03217 390333000138 Bacterial surface layer protein; Region: SLAP; pfam03217 390333000139 Bacterial surface layer protein; Region: SLAP; pfam03217 390333000140 Bacterial surface layer protein; Region: SLAP; pfam03217 390333000141 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl17272 390333000142 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b2; cd09204 390333000143 PLD-like domain; Region: PLDc_2; pfam13091 390333000144 putative homodimer interface [polypeptide binding]; other site 390333000145 putative active site [active] 390333000146 catalytic site [active] 390333000147 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 390333000148 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 390333000149 ATP binding site [chemical binding]; other site 390333000150 putative Mg++ binding site [ion binding]; other site 390333000151 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 390333000152 nucleotide binding region [chemical binding]; other site 390333000153 ATP-binding site [chemical binding]; other site 390333000154 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 390333000155 YcxB-like protein; Region: YcxB; pfam14317 390333000156 Transcriptional regulator; Region: Rrf2; pfam02082 390333000157 Rrf2 family protein; Region: rrf2_super; TIGR00738 390333000158 4-oxalocrotonate tautomerase; Provisional; Region: PRK02220 390333000159 active site 1 [active] 390333000160 dimer interface [polypeptide binding]; other site 390333000161 hexamer interface [polypeptide binding]; other site 390333000162 active site 2 [active] 390333000163 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 390333000164 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 390333000165 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290 390333000166 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 390333000167 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 390333000168 DNA binding residues [nucleotide binding] 390333000169 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 390333000170 amphipathic channel; other site 390333000171 Asn-Pro-Ala signature motifs; other site 390333000172 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 390333000173 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 390333000174 Ligand binding site; other site 390333000175 Putative Catalytic site; other site 390333000176 DXD motif; other site 390333000177 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 390333000178 EDD domain protein, DegV family; Region: DegV; TIGR00762 390333000179 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 390333000180 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 390333000181 Isoamyl-acetate hydrolyzing esterase-like proteins. SGNH_hydrolase subfamily similar to the Saccharomyces cerevisiae IAH1. IAH1 may be the major esterase that hydrolyses isoamyl acetate in sake mash. The SGNH-family of hydrolases is a diverse family of...; Region: Isoamyl_acetate_hydrolase_like; cd01838 390333000182 catalytic triad [active] 390333000183 oxyanion hole [active] 390333000184 active site 390333000185 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 390333000186 catalytic core [active] 390333000187 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 390333000188 RRXRR protein; Region: RRXRR; pfam14239 390333000189 similar to hypothetical protein; This sequence makes part of ISL4 390333000190 similar to hypothetical protein; This sequence makes part of ISL4 390333000191 BioY family; Region: BioY; pfam02632 390333000192 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 390333000193 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 390333000194 motif II; other site 390333000195 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 390333000196 active site 390333000197 putative catalytic site [active] 390333000198 DNA binding site [nucleotide binding] 390333000199 putative phosphate binding site [ion binding]; other site 390333000200 metal binding site A [ion binding]; metal-binding site 390333000201 AP binding site [nucleotide binding]; other site 390333000202 metal binding site B [ion binding]; metal-binding site 390333000203 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 390333000204 tetramer (dimer of dimers) interface [polypeptide binding]; other site 390333000205 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 390333000206 NAD binding site [chemical binding]; other site 390333000207 dimer interface [polypeptide binding]; other site 390333000208 substrate binding site [chemical binding]; other site 390333000209 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 390333000210 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 390333000211 active site 390333000212 catalytic tetrad [active] 390333000213 ribonucleoside-triphosphate reductase, adenosylcobalamin-dependent; Region: RTPR; TIGR02505 390333000214 Class II ribonucleotide reductase, monomeric form; Region: RNR_II_monomer; cd01676 390333000215 putative active site [active] 390333000216 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 390333000217 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 390333000218 Helix-turn-helix domain; Region: HTH_38; pfam13936 390333000219 Integrase core domain; Region: rve; pfam00665 390333000220 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 390333000221 D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186 390333000222 homodimer interface [polypeptide binding]; other site 390333000223 ligand binding site [chemical binding]; other site 390333000224 NAD binding site [chemical binding]; other site 390333000225 catalytic site [active] 390333000226 FAD binding domain; Region: FAD_binding_4; pfam01565 390333000227 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 390333000228 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 390333000229 active site 390333000230 catalytic residues [active] 390333000231 metal binding site [ion binding]; metal-binding site 390333000232 NLPA lipoprotein; Region: Lipoprotein_9; cl17547 390333000233 S-ribosylhomocysteinase; Provisional; Region: PRK02260 390333000234 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 390333000235 Walker A/P-loop; other site 390333000236 ATP binding site [chemical binding]; other site 390333000237 ABC transporter; Region: ABC_tran; pfam00005 390333000238 Q-loop/lid; other site 390333000239 ABC transporter signature motif; other site 390333000240 Walker B; other site 390333000241 D-loop; other site 390333000242 H-loop/switch region; other site 390333000243 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 390333000244 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 390333000245 Walker A/P-loop; other site 390333000246 ATP binding site [chemical binding]; other site 390333000247 Q-loop/lid; other site 390333000248 ABC transporter signature motif; other site 390333000249 Walker B; other site 390333000250 D-loop; other site 390333000251 H-loop/switch region; other site 390333000252 Transcriptional regulator [Transcription]; Region: LysR; COG0583 390333000253 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 390333000254 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 390333000255 dimerization interface [polypeptide binding]; other site 390333000256 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 390333000257 substrate binding site [chemical binding]; other site 390333000258 THF binding site; other site 390333000259 zinc-binding site [ion binding]; other site 390333000260 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 390333000261 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 390333000262 nucleotide binding site [chemical binding]; other site 390333000263 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 390333000264 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 390333000265 tetramer (dimer of dimers) interface [polypeptide binding]; other site 390333000266 NAD binding site [chemical binding]; other site 390333000267 dimer interface [polypeptide binding]; other site 390333000268 substrate binding site [chemical binding]; other site 390333000269 benzoate transport; Region: 2A0115; TIGR00895 390333000270 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 390333000271 putative substrate translocation pore; other site 390333000272 Major Facilitator Superfamily; Region: MFS_1; pfam07690 390333000273 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 390333000274 putative substrate translocation pore; other site 390333000275 Transcriptional regulator [Transcription]; Region: LysR; COG0583 390333000276 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 390333000277 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 390333000278 putative dimerization interface [polypeptide binding]; other site 390333000279 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 390333000280 L-aspartate oxidase; Provisional; Region: PRK06175 390333000281 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 390333000282 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 390333000283 putative acyl-acceptor binding pocket; other site 390333000284 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 390333000285 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 390333000286 active site 390333000287 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 390333000288 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 390333000289 putative acyl-acceptor binding pocket; other site 390333000290 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 390333000291 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 390333000292 active site 390333000293 phosphorylation site [posttranslational modification] 390333000294 intermolecular recognition site; other site 390333000295 dimerization interface [polypeptide binding]; other site 390333000296 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 390333000297 DNA binding site [nucleotide binding] 390333000298 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 390333000299 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 390333000300 dimerization interface [polypeptide binding]; other site 390333000301 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 390333000302 putative active site [active] 390333000303 heme pocket [chemical binding]; other site 390333000304 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 390333000305 dimer interface [polypeptide binding]; other site 390333000306 phosphorylation site [posttranslational modification] 390333000307 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 390333000308 ATP binding site [chemical binding]; other site 390333000309 Mg2+ binding site [ion binding]; other site 390333000310 G-X-G motif; other site 390333000311 YycH protein; Region: YycH; pfam07435 390333000312 YycH protein; Region: YycI; pfam09648 390333000313 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 390333000314 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 390333000315 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 390333000316 protein binding site [polypeptide binding]; other site 390333000317 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 390333000318 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 390333000319 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 390333000320 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 390333000321 Walker A/P-loop; other site 390333000322 ATP binding site [chemical binding]; other site 390333000323 Q-loop/lid; other site 390333000324 ABC transporter signature motif; other site 390333000325 Walker B; other site 390333000326 D-loop; other site 390333000327 H-loop/switch region; other site 390333000328 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 390333000329 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 390333000330 Walker A/P-loop; other site 390333000331 ATP binding site [chemical binding]; other site 390333000332 Q-loop/lid; other site 390333000333 ABC transporter signature motif; other site 390333000334 Walker B; other site 390333000335 D-loop; other site 390333000336 H-loop/switch region; other site 390333000337 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 390333000338 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 390333000339 putative substrate translocation pore; other site 390333000340 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 390333000341 Helix-turn-helix domain; Region: HTH_18; pfam12833 390333000342 ATP-binding cassette domain of an uncharacterized transporter similar in sequence to NatA; Region: ABC_NatA_like; cd03267 390333000343 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 390333000344 Walker A/P-loop; other site 390333000345 ATP binding site [chemical binding]; other site 390333000346 Q-loop/lid; other site 390333000347 ABC transporter signature motif; other site 390333000348 Walker B; other site 390333000349 D-loop; other site 390333000350 H-loop/switch region; other site 390333000351 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 390333000352 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 390333000353 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 390333000354 YcaO-like family; Region: YcaO; pfam02624 390333000355 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 390333000356 non-specific DNA binding site [nucleotide binding]; other site 390333000357 salt bridge; other site 390333000358 sequence-specific DNA binding site [nucleotide binding]; other site 390333000359 heat shock protein HtpX; Provisional; Region: PRK04897 390333000360 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 390333000361 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 390333000362 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 390333000363 transmembrane helices; other site 390333000364 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 390333000365 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 390333000366 active site 390333000367 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 390333000368 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 390333000369 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 390333000370 NlpC/P60 family; Region: NLPC_P60; pfam00877 390333000371 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 390333000372 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 390333000373 Walker A/P-loop; other site 390333000374 ATP binding site [chemical binding]; other site 390333000375 Q-loop/lid; other site 390333000376 ABC transporter signature motif; other site 390333000377 Walker B; other site 390333000378 D-loop; other site 390333000379 H-loop/switch region; other site 390333000380 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 390333000381 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 390333000382 substrate binding pocket [chemical binding]; other site 390333000383 membrane-bound complex binding site; other site 390333000384 hinge residues; other site 390333000385 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 390333000386 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 390333000387 dimer interface [polypeptide binding]; other site 390333000388 conserved gate region; other site 390333000389 putative PBP binding loops; other site 390333000390 ABC-ATPase subunit interface; other site 390333000391 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 390333000392 active site 390333000393 DNA binding site [nucleotide binding] 390333000394 Protein of unknown function, DUF488; Region: DUF488; cl01246 390333000395 NAD-dependent deacetylase; Provisional; Region: PRK00481 390333000396 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 390333000397 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 390333000398 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 390333000399 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 390333000400 putative active site [active] 390333000401 catalytic site [active] 390333000402 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 390333000403 putative active site [active] 390333000404 catalytic site [active] 390333000405 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 390333000406 Caulimovirus viroplasmin; Region: Cauli_VI; pfam01693 390333000407 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 390333000408 RNA/DNA hybrid binding site [nucleotide binding]; other site 390333000409 active site 390333000410 Predicted secreted protein [Function unknown]; Region: COG4086 390333000411 Protein of unknown function (DUF1002); Region: DUF1002; pfam06207 390333000412 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 390333000413 active site 390333000414 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 390333000415 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 390333000416 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 390333000417 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 390333000418 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 390333000419 active site 390333000420 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 390333000421 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 390333000422 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 390333000423 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 390333000424 ligand binding site [chemical binding]; other site 390333000425 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 390333000426 non-specific DNA interactions [nucleotide binding]; other site 390333000427 DNA binding site [nucleotide binding] 390333000428 sequence specific DNA binding site [nucleotide binding]; other site 390333000429 putative cAMP binding site [chemical binding]; other site 390333000430 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 390333000431 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 390333000432 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 390333000433 ATP-grasp domain; Region: ATP-grasp_4; cl17255 390333000434 YibE/F-like protein; Region: YibE_F; pfam07907 390333000435 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 390333000436 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 390333000437 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 390333000438 nucleophilic elbow; other site 390333000439 catalytic triad; other site 390333000440 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 390333000441 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 390333000442 dimer interface [polypeptide binding]; other site 390333000443 conserved gate region; other site 390333000444 ABC-ATPase subunit interface; other site 390333000445 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 390333000446 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 390333000447 active site 390333000448 catalytic site [active] 390333000449 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 390333000450 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 390333000451 Interdomain contacts; other site 390333000452 Cytokine receptor motif; other site 390333000453 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 390333000454 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 390333000455 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 390333000456 active site 390333000457 dimer interface [polypeptide binding]; other site 390333000458 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014 390333000459 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 390333000460 active site 390333000461 phosphorylation site [posttranslational modification] 390333000462 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 390333000463 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 390333000464 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 390333000465 Ligand Binding Site [chemical binding]; other site 390333000466 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 390333000467 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 390333000468 substrate binding pocket [chemical binding]; other site 390333000469 membrane-bound complex binding site; other site 390333000470 hinge residues; other site 390333000471 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 390333000472 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 390333000473 Walker A/P-loop; other site 390333000474 ATP binding site [chemical binding]; other site 390333000475 Q-loop/lid; other site 390333000476 ABC transporter signature motif; other site 390333000477 Walker B; other site 390333000478 D-loop; other site 390333000479 H-loop/switch region; other site 390333000480 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 390333000481 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 390333000482 dimer interface [polypeptide binding]; other site 390333000483 conserved gate region; other site 390333000484 ABC-ATPase subunit interface; other site 390333000485 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 390333000486 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 390333000487 dimer interface [polypeptide binding]; other site 390333000488 conserved gate region; other site 390333000489 putative PBP binding loops; other site 390333000490 ABC-ATPase subunit interface; other site 390333000491 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 390333000492 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 390333000493 peptide binding site [polypeptide binding]; other site 390333000494 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 390333000495 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 390333000496 active site 390333000497 metal binding site [ion binding]; metal-binding site 390333000498 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 390333000499 active site 390333000500 dimer interface [polypeptide binding]; other site 390333000501 Glutamine amidotransferase domain; Region: GATase_6; pfam13522 390333000502 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 390333000503 Ligand Binding Site [chemical binding]; other site 390333000504 Molecular Tunnel; other site 390333000505 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 390333000506 Predicted ATP-grasp enzyme [General function prediction only]; Region: COG3919 390333000507 ATP-grasp domain; Region: ATP-grasp_4; cl17255 390333000508 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 390333000509 Class III ribonucleotide reductase; Region: RNR_III; cd01675 390333000510 effector binding site; other site 390333000511 active site 390333000512 Zn binding site [ion binding]; other site 390333000513 glycine loop; other site 390333000514 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 390333000515 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 390333000516 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 390333000517 Major Facilitator Superfamily; Region: MFS_1; pfam07690 390333000518 putative substrate translocation pore; other site 390333000519 Glutaredoxin-related protein [Posttranslational modification, protein turnover, chaperones]; Region: COG4545 390333000520 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 390333000521 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 390333000522 active site 390333000523 Zn binding site [ion binding]; other site 390333000524 K+ potassium transporter; Region: K_trans; pfam02705 390333000525 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 390333000526 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361 390333000527 Bacterial surface layer protein; Region: SLAP; pfam03217 390333000528 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 390333000529 amidase catalytic site [active] 390333000530 Zn binding residues [ion binding]; other site 390333000531 substrate binding site [chemical binding]; other site 390333000532 Bacterial surface layer protein; Region: SLAP; pfam03217 390333000533 Bacterial surface layer protein; Region: SLAP; pfam03217 390333000534 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 390333000535 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 390333000536 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 390333000537 TrkA-N domain; Region: TrkA_N; pfam02254 390333000538 TrkA-C domain; Region: TrkA_C; pfam02080 390333000539 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 390333000540 catalytic core [active] 390333000541 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 390333000542 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 390333000543 membrane protein; Provisional; Region: PRK14411 390333000544 Sulfatase; Region: Sulfatase; cl17466 390333000545 similar to hypothetical protein; This sequence makes part of ISL4 390333000546 similar to hypothetical protein; This sequence makes part of ISL4 390333000547 Dihydroneopterin aldolase; Region: FolB; pfam02152 390333000548 active site 390333000549 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 390333000550 catalytic center binding site [active] 390333000551 ATP binding site [chemical binding]; other site 390333000552 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 390333000553 GTP cyclohydrolase I; Provisional; Region: PLN03044 390333000554 active site 390333000555 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 390333000556 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 390333000557 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 390333000558 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 390333000559 dihydropteroate synthase; Region: DHPS; TIGR01496 390333000560 substrate binding pocket [chemical binding]; other site 390333000561 dimer interface [polypeptide binding]; other site 390333000562 inhibitor binding site; inhibition site 390333000563 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 390333000564 nudix motif; other site 390333000565 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 390333000566 dimer interface [polypeptide binding]; other site 390333000567 conserved gate region; other site 390333000568 putative PBP binding loops; other site 390333000569 ABC-ATPase subunit interface; other site 390333000570 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 390333000571 dimer interface [polypeptide binding]; other site 390333000572 conserved gate region; other site 390333000573 putative PBP binding loops; other site 390333000574 ABC-ATPase subunit interface; other site 390333000575 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 390333000576 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 390333000577 Walker A/P-loop; other site 390333000578 ATP binding site [chemical binding]; other site 390333000579 Q-loop/lid; other site 390333000580 ABC transporter signature motif; other site 390333000581 Walker B; other site 390333000582 D-loop; other site 390333000583 H-loop/switch region; other site 390333000584 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 390333000585 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 390333000586 substrate binding pocket [chemical binding]; other site 390333000587 membrane-bound complex binding site; other site 390333000588 hinge residues; other site 390333000589 tyrosyl-tRNA synthetase; Provisional; Region: PRK13354 390333000590 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 390333000591 active site 390333000592 HIGH motif; other site 390333000593 dimer interface [polypeptide binding]; other site 390333000594 KMSKS motif; other site 390333000595 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 390333000596 RNA binding surface [nucleotide binding]; other site 390333000597 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 390333000598 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 390333000599 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 390333000600 metal binding site [ion binding]; metal-binding site 390333000601 dimer interface [polypeptide binding]; other site 390333000602 Uncharacterized conserved protein (DUF2075); Region: DUF2075; pfam09848 390333000603 AAA ATPase domain; Region: AAA_16; pfam13191 390333000604 Uncharacterized conserved protein [Function unknown]; Region: COG3410 390333000605 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 390333000606 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 390333000607 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 390333000608 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 390333000609 peptide binding site [polypeptide binding]; other site 390333000610 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 390333000611 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 390333000612 peptide binding site [polypeptide binding]; other site 390333000613 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 390333000614 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 390333000615 dimer interface [polypeptide binding]; other site 390333000616 conserved gate region; other site 390333000617 putative PBP binding loops; other site 390333000618 ABC-ATPase subunit interface; other site 390333000619 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 390333000620 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 390333000621 dimer interface [polypeptide binding]; other site 390333000622 conserved gate region; other site 390333000623 putative PBP binding loops; other site 390333000624 ABC-ATPase subunit interface; other site 390333000625 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 390333000626 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 390333000627 Walker A/P-loop; other site 390333000628 ATP binding site [chemical binding]; other site 390333000629 Q-loop/lid; other site 390333000630 ABC transporter signature motif; other site 390333000631 Walker B; other site 390333000632 D-loop; other site 390333000633 H-loop/switch region; other site 390333000634 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 390333000635 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 390333000636 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 390333000637 Walker A/P-loop; other site 390333000638 ATP binding site [chemical binding]; other site 390333000639 Q-loop/lid; other site 390333000640 ABC transporter signature motif; other site 390333000641 Walker B; other site 390333000642 D-loop; other site 390333000643 H-loop/switch region; other site 390333000644 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 390333000645 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 390333000646 trimer interface [polypeptide binding]; other site 390333000647 active site 390333000648 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 390333000649 trimer interface [polypeptide binding]; other site 390333000650 active site 390333000651 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 390333000652 Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471 390333000653 putative dimer interface [polypeptide binding]; other site 390333000654 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 390333000655 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 390333000656 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 390333000657 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 390333000658 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 390333000659 GDP-binding site [chemical binding]; other site 390333000660 ACT binding site; other site 390333000661 IMP binding site; other site 390333000662 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 390333000663 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 390333000664 active site 390333000665 DNA polymerase IV; Reviewed; Region: PRK03103 390333000666 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 390333000667 active site 390333000668 DNA binding site [nucleotide binding] 390333000669 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 390333000670 xanthine permease; Region: pbuX; TIGR03173 390333000671 Sulfate transporter family; Region: Sulfate_transp; pfam00916 390333000672 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 390333000673 active site 390333000674 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK06843 390333000675 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 390333000676 active site 390333000677 GMP synthase; Reviewed; Region: guaA; PRK00074 390333000678 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 390333000679 AMP/PPi binding site [chemical binding]; other site 390333000680 candidate oxyanion hole; other site 390333000681 catalytic triad [active] 390333000682 potential glutamine specificity residues [chemical binding]; other site 390333000683 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 390333000684 ATP Binding subdomain [chemical binding]; other site 390333000685 Ligand Binding sites [chemical binding]; other site 390333000686 Dimerization subdomain; other site 390333000687 YcfA-like protein; Region: YcfA; cl00752 390333000688 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 390333000689 HicB family; Region: HicB; pfam05534 390333000690 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 390333000691 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 390333000692 active site 390333000693 ATP binding site [chemical binding]; other site 390333000694 substrate binding site [chemical binding]; other site 390333000695 activation loop (A-loop); other site 390333000696 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 390333000697 active site 390333000698 zinc binding site [ion binding]; other site 390333000699 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 390333000700 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 390333000701 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 390333000702 Walker A/P-loop; other site 390333000703 ATP binding site [chemical binding]; other site 390333000704 Q-loop/lid; other site 390333000705 ABC transporter signature motif; other site 390333000706 Walker B; other site 390333000707 D-loop; other site 390333000708 H-loop/switch region; other site 390333000709 Cupin domain; Region: Cupin_2; pfam07883 390333000710 Helix-turn-helix domain; Region: HTH_18; pfam12833 390333000711 Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048 390333000712 Predicted ATP-grasp enzyme [General function prediction only]; Region: COG3919 390333000713 ATP-grasp domain; Region: ATP-grasp_4; cl17255 390333000714 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 390333000715 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 390333000716 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 390333000717 putative DNA binding site [nucleotide binding]; other site 390333000718 homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485 390333000719 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 390333000720 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 390333000721 putative deacylase active site [active] 390333000722 Chorismate mutase type II; Region: CM_2; pfam01817 390333000723 Transcriptional regulators [Transcription]; Region: MarR; COG1846 390333000724 MarR family; Region: MarR_2; pfam12802 390333000725 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 390333000726 active site 390333000727 homodimer interface [polypeptide binding]; other site 390333000728 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 390333000729 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 390333000730 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 390333000731 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 390333000732 active site 390333000733 Isochorismatase family; Region: Isochorismatase; pfam00857 390333000734 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 390333000735 catalytic triad [active] 390333000736 conserved cis-peptide bond; other site 390333000737 Protein of unknown function (DUF1294); Region: DUF1294; pfam06961 390333000738 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 390333000739 nudix motif; other site 390333000740 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 390333000741 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 390333000742 Probable transposase; Region: OrfB_IS605; pfam01385 390333000743 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 390333000744 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 390333000745 Enterocin A Immunity; Region: EntA_Immun; pfam08951 390333000746 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 390333000747 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 390333000748 ABC-2 type transporter; Region: ABC2_membrane; cl17235 390333000749 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 390333000750 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 390333000751 Walker A/P-loop; other site 390333000752 ATP binding site [chemical binding]; other site 390333000753 Q-loop/lid; other site 390333000754 ABC transporter signature motif; other site 390333000755 Walker B; other site 390333000756 D-loop; other site 390333000757 H-loop/switch region; other site 390333000758 Subunit A of Class III extradiol dioxygenases; Region: Extradiol_Dioxygenase_3A_like; cd07321 390333000759 dimer interface [polypeptide binding]; other site 390333000760 tetramer interface [polypeptide binding]; other site 390333000761 CAAX protease self-immunity; Region: Abi; pfam02517 390333000762 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 390333000763 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 390333000764 active site 390333000765 HIGH motif; other site 390333000766 dimer interface [polypeptide binding]; other site 390333000767 KMSKS motif; other site 390333000768 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 390333000769 catalytic motif [active] 390333000770 Zn binding site [ion binding]; other site 390333000771 magnesium-transporting ATPase; Provisional; Region: PRK15122 390333000772 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 390333000773 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 390333000774 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 390333000775 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 390333000776 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 390333000777 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 390333000778 active site 390333000779 HIGH motif; other site 390333000780 KMSKS motif; other site 390333000781 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 390333000782 tRNA binding surface [nucleotide binding]; other site 390333000783 anticodon binding site; other site 390333000784 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 390333000785 dimer interface [polypeptide binding]; other site 390333000786 putative tRNA-binding site [nucleotide binding]; other site 390333000787 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 390333000788 active site 390333000789 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 390333000790 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 390333000791 putative active site [active] 390333000792 putative metal binding site [ion binding]; other site 390333000793 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 390333000794 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 390333000795 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 390333000796 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 390333000797 pur operon repressor; Provisional; Region: PRK09213 390333000798 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 390333000799 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 390333000800 active site 390333000801 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 390333000802 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 390333000803 Substrate binding site; other site 390333000804 Mg++ binding site; other site 390333000805 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 390333000806 active site 390333000807 substrate binding site [chemical binding]; other site 390333000808 CoA binding site [chemical binding]; other site 390333000809 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 390333000810 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 390333000811 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 390333000812 active site 390333000813 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 390333000814 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 390333000815 Zn2+ binding site [ion binding]; other site 390333000816 Mg2+ binding site [ion binding]; other site 390333000817 Domain of unknown function (DUF1934); Region: DUF1934; pfam09148 390333000818 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 390333000819 CTP synthetase; Validated; Region: pyrG; PRK05380 390333000820 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 390333000821 Catalytic site [active] 390333000822 active site 390333000823 UTP binding site [chemical binding]; other site 390333000824 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 390333000825 active site 390333000826 putative oxyanion hole; other site 390333000827 catalytic triad [active] 390333000828 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 390333000829 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 390333000830 hinge; other site 390333000831 active site 390333000832 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 390333000833 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 390333000834 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 390333000835 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 390333000836 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 390333000837 DEAD-like helicases superfamily; Region: DEXDc; smart00487 390333000838 ATP binding site [chemical binding]; other site 390333000839 Mg++ binding site [ion binding]; other site 390333000840 motif III; other site 390333000841 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 390333000842 nucleotide binding region [chemical binding]; other site 390333000843 ATP-binding site [chemical binding]; other site 390333000844 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 390333000845 alanine racemase; Reviewed; Region: alr; PRK00053 390333000846 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 390333000847 active site 390333000848 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 390333000849 dimer interface [polypeptide binding]; other site 390333000850 substrate binding site [chemical binding]; other site 390333000851 catalytic residues [active] 390333000852 FOG: CBS domain [General function prediction only]; Region: COG0517 390333000853 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 390333000854 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 390333000855 putative active site [active] 390333000856 catalytic residue [active] 390333000857 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 390333000858 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 390333000859 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 390333000860 ATP binding site [chemical binding]; other site 390333000861 putative Mg++ binding site [ion binding]; other site 390333000862 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 390333000863 nucleotide binding region [chemical binding]; other site 390333000864 ATP-binding site [chemical binding]; other site 390333000865 TRCF domain; Region: TRCF; pfam03461 390333000866 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 390333000867 RNA binding surface [nucleotide binding]; other site 390333000868 Septum formation initiator; Region: DivIC; pfam04977 390333000869 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 390333000870 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 390333000871 RNA binding site [nucleotide binding]; other site 390333000872 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 390333000873 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 390333000874 Ligand Binding Site [chemical binding]; other site 390333000875 TilS substrate C-terminal domain; Region: TilS_C; smart00977 390333000876 FtsH Extracellular; Region: FtsH_ext; pfam06480 390333000877 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 390333000878 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 390333000879 Walker A motif; other site 390333000880 ATP binding site [chemical binding]; other site 390333000881 Walker B motif; other site 390333000882 arginine finger; other site 390333000883 Peptidase family M41; Region: Peptidase_M41; pfam01434 390333000884 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 390333000885 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 390333000886 dimerization interface [polypeptide binding]; other site 390333000887 domain crossover interface; other site 390333000888 redox-dependent activation switch; other site 390333000889 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 390333000890 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 390333000891 peptide binding site [polypeptide binding]; other site 390333000892 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 390333000893 peptidase T; Region: peptidase-T; TIGR01882 390333000894 metal binding site [ion binding]; metal-binding site 390333000895 dimer interface [polypeptide binding]; other site 390333000896 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 390333000897 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 390333000898 FMN binding site [chemical binding]; other site 390333000899 active site 390333000900 catalytic residues [active] 390333000901 substrate binding site [chemical binding]; other site 390333000902 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 390333000903 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 390333000904 dimer interface [polypeptide binding]; other site 390333000905 putative anticodon binding site; other site 390333000906 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 390333000907 motif 1; other site 390333000908 active site 390333000909 motif 2; other site 390333000910 motif 3; other site 390333000911 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 390333000912 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 390333000913 metal binding site [ion binding]; metal-binding site 390333000914 active site 390333000915 I-site; other site 390333000916 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 390333000917 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 390333000918 Clp amino terminal domain; Region: Clp_N; pfam02861 390333000919 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 390333000920 Walker A motif; other site 390333000921 ATP binding site [chemical binding]; other site 390333000922 Walker B motif; other site 390333000923 arginine finger; other site 390333000924 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 390333000925 Walker A motif; other site 390333000926 ATP binding site [chemical binding]; other site 390333000927 Walker B motif; other site 390333000928 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 390333000929 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 390333000930 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 390333000931 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 390333000932 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 390333000933 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 390333000934 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 390333000935 RPB10 interaction site [polypeptide binding]; other site 390333000936 RPB1 interaction site [polypeptide binding]; other site 390333000937 RPB11 interaction site [polypeptide binding]; other site 390333000938 RPB3 interaction site [polypeptide binding]; other site 390333000939 RPB12 interaction site [polypeptide binding]; other site 390333000940 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 390333000941 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 390333000942 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 390333000943 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 390333000944 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 390333000945 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 390333000946 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 390333000947 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 390333000948 G-loop; other site 390333000949 DNA binding site [nucleotide binding] 390333000950 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 390333000951 S17 interaction site [polypeptide binding]; other site 390333000952 S8 interaction site; other site 390333000953 16S rRNA interaction site [nucleotide binding]; other site 390333000954 streptomycin interaction site [chemical binding]; other site 390333000955 23S rRNA interaction site [nucleotide binding]; other site 390333000956 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 390333000957 30S ribosomal protein S7; Validated; Region: PRK05302 390333000958 elongation factor G; Reviewed; Region: PRK12739 390333000959 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 390333000960 G1 box; other site 390333000961 putative GEF interaction site [polypeptide binding]; other site 390333000962 GTP/Mg2+ binding site [chemical binding]; other site 390333000963 Switch I region; other site 390333000964 G2 box; other site 390333000965 G3 box; other site 390333000966 Switch II region; other site 390333000967 G4 box; other site 390333000968 G5 box; other site 390333000969 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 390333000970 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 390333000971 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 390333000972 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 390333000973 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 390333000974 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 390333000975 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 390333000976 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 390333000977 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 390333000978 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 390333000979 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 390333000980 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 390333000981 putative translocon binding site; other site 390333000982 protein-rRNA interface [nucleotide binding]; other site 390333000983 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 390333000984 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 390333000985 G-X-X-G motif; other site 390333000986 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 390333000987 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 390333000988 23S rRNA interface [nucleotide binding]; other site 390333000989 5S rRNA interface [nucleotide binding]; other site 390333000990 putative antibiotic binding site [chemical binding]; other site 390333000991 L25 interface [polypeptide binding]; other site 390333000992 L27 interface [polypeptide binding]; other site 390333000993 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 390333000994 23S rRNA interface [nucleotide binding]; other site 390333000995 putative translocon interaction site; other site 390333000996 signal recognition particle (SRP54) interaction site; other site 390333000997 L23 interface [polypeptide binding]; other site 390333000998 trigger factor interaction site; other site 390333000999 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 390333001000 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 390333001001 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 390333001002 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 390333001003 RNA binding site [nucleotide binding]; other site 390333001004 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 390333001005 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 390333001006 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 390333001007 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 390333001008 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 390333001009 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 390333001010 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 390333001011 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 390333001012 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 390333001013 5S rRNA interface [nucleotide binding]; other site 390333001014 L27 interface [polypeptide binding]; other site 390333001015 23S rRNA interface [nucleotide binding]; other site 390333001016 L5 interface [polypeptide binding]; other site 390333001017 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 390333001018 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 390333001019 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 390333001020 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 390333001021 23S rRNA binding site [nucleotide binding]; other site 390333001022 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 390333001023 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 390333001024 SecY translocase; Region: SecY; pfam00344 390333001025 adenylate kinase; Reviewed; Region: adk; PRK00279 390333001026 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 390333001027 AMP-binding site [chemical binding]; other site 390333001028 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 390333001029 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 390333001030 rRNA binding site [nucleotide binding]; other site 390333001031 predicted 30S ribosome binding site; other site 390333001032 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 390333001033 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 390333001034 30S ribosomal protein S13; Region: bact_S13; TIGR03631 390333001035 30S ribosomal protein S11; Validated; Region: PRK05309 390333001036 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 390333001037 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 390333001038 alphaNTD homodimer interface [polypeptide binding]; other site 390333001039 alphaNTD - beta interaction site [polypeptide binding]; other site 390333001040 alphaNTD - beta' interaction site [polypeptide binding]; other site 390333001041 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 390333001042 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 390333001043 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13640 390333001044 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 390333001045 Walker A/P-loop; other site 390333001046 ATP binding site [chemical binding]; other site 390333001047 Q-loop/lid; other site 390333001048 ABC transporter signature motif; other site 390333001049 Walker B; other site 390333001050 D-loop; other site 390333001051 H-loop/switch region; other site 390333001052 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13641 390333001053 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 390333001054 Walker A/P-loop; other site 390333001055 ATP binding site [chemical binding]; other site 390333001056 Q-loop/lid; other site 390333001057 ABC transporter signature motif; other site 390333001058 Walker B; other site 390333001059 D-loop; other site 390333001060 H-loop/switch region; other site 390333001061 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 390333001062 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 390333001063 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 390333001064 dimerization interface 3.5A [polypeptide binding]; other site 390333001065 active site 390333001066 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 390333001067 23S rRNA interface [nucleotide binding]; other site 390333001068 L3 interface [polypeptide binding]; other site 390333001069 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 390333001070 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 390333001071 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 390333001072 nudix motif; other site 390333001073 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 390333001074 substrate binding site [chemical binding]; other site 390333001075 aromatic amino acid aminotransferase; Validated; Region: PRK07309 390333001076 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 390333001077 pyridoxal 5'-phosphate binding site [chemical binding]; other site 390333001078 homodimer interface [polypeptide binding]; other site 390333001079 catalytic residue [active] 390333001080 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 390333001081 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 390333001082 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 390333001083 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 390333001084 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 390333001085 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 390333001086 DNA-binding site [nucleotide binding]; DNA binding site 390333001087 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 390333001088 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 390333001089 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 390333001090 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 390333001091 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 390333001092 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 390333001093 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 390333001094 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 390333001095 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 390333001096 Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488 390333001097 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 390333001098 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 390333001099 homodimer interface [polypeptide binding]; other site 390333001100 NAD binding pocket [chemical binding]; other site 390333001101 ATP binding pocket [chemical binding]; other site 390333001102 Mg binding site [ion binding]; other site 390333001103 active-site loop [active] 390333001104 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 390333001105 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 390333001106 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 390333001107 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 390333001108 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 390333001109 motif II; other site 390333001110 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 390333001111 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 390333001112 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 390333001113 Walker A/P-loop; other site 390333001114 ATP binding site [chemical binding]; other site 390333001115 Q-loop/lid; other site 390333001116 ABC transporter signature motif; other site 390333001117 Walker B; other site 390333001118 D-loop; other site 390333001119 H-loop/switch region; other site 390333001120 SprT homologues; Region: SprT; cl01182 390333001121 hypothetical protein; Provisional; Region: PRK04351 390333001122 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 390333001123 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 390333001124 Part of AAA domain; Region: AAA_19; pfam13245 390333001125 Family description; Region: UvrD_C_2; pfam13538 390333001126 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 390333001127 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 390333001128 nucleotide binding pocket [chemical binding]; other site 390333001129 K-X-D-G motif; other site 390333001130 catalytic site [active] 390333001131 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 390333001132 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 390333001133 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 390333001134 Dimer interface [polypeptide binding]; other site 390333001135 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 390333001136 putative dimer interface [polypeptide binding]; other site 390333001137 CamS sex pheromone cAM373 precursor; Region: CamS; pfam07537 390333001138 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 390333001139 putative dimer interface [polypeptide binding]; other site 390333001140 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 390333001141 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 390333001142 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 390333001143 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 390333001144 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 390333001145 GatB domain; Region: GatB_Yqey; smart00845 390333001146 putative lipid kinase; Reviewed; Region: PRK13337 390333001147 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 390333001148 Protein of unknown function (DUF1211); Region: DUF1211; pfam06736 390333001149 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 390333001150 TRAM domain; Region: TRAM; pfam01938 390333001151 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 390333001152 S-adenosylmethionine binding site [chemical binding]; other site 390333001153 Mrr N-terminal domain; Region: Mrr_N; pfam14338 390333001154 Restriction endonuclease; Region: Mrr_cat; pfam04471 390333001155 Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124 390333001156 active site 390333001157 zinc binding site [ion binding]; other site 390333001158 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 390333001159 metal-binding site [ion binding] 390333001160 iron-sulfur cluster repair di-iron protein; Region: FeS_repair_RIC; TIGR03652 390333001161 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 390333001162 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 390333001163 ligand binding site [chemical binding]; other site 390333001164 flexible hinge region; other site 390333001165 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 390333001166 putative switch regulator; other site 390333001167 non-specific DNA interactions [nucleotide binding]; other site 390333001168 DNA binding site [nucleotide binding] 390333001169 sequence specific DNA binding site [nucleotide binding]; other site 390333001170 putative cAMP binding site [chemical binding]; other site 390333001171 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 390333001172 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 390333001173 A new structural DNA glycosylase containing HEAT-like repeats; Region: AlkD_like_1; cd07064 390333001174 active site 390333001175 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 390333001176 putative NADH binding site [chemical binding]; other site 390333001177 putative active site [active] 390333001178 nudix motif; other site 390333001179 putative metal binding site [ion binding]; other site 390333001180 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 390333001181 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 390333001182 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 390333001183 putative DNA binding site [nucleotide binding]; other site 390333001184 putative Zn2+ binding site [ion binding]; other site 390333001185 AsnC family; Region: AsnC_trans_reg; pfam01037 390333001186 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 390333001187 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 390333001188 glutaminase active site [active] 390333001189 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 390333001190 dimer interface [polypeptide binding]; other site 390333001191 active site 390333001192 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 390333001193 dimer interface [polypeptide binding]; other site 390333001194 active site 390333001195 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 390333001196 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 390333001197 Predicted permeases [General function prediction only]; Region: COG0679 390333001198 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 390333001199 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 390333001200 Walker A/P-loop; other site 390333001201 ATP binding site [chemical binding]; other site 390333001202 Q-loop/lid; other site 390333001203 ABC transporter signature motif; other site 390333001204 Walker B; other site 390333001205 D-loop; other site 390333001206 H-loop/switch region; other site 390333001207 ABC transporter; Region: ABC_tran_2; pfam12848 390333001208 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 390333001209 drug efflux system protein MdtG; Provisional; Region: PRK09874 390333001210 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 390333001211 putative substrate translocation pore; other site 390333001212 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 390333001213 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 390333001214 glutamate racemase; Provisional; Region: PRK00865 390333001215 Peptidase family C69; Region: Peptidase_C69; pfam03577 390333001216 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 390333001217 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 390333001218 oligomer interface [polypeptide binding]; other site 390333001219 active site 390333001220 metal binding site [ion binding]; metal-binding site 390333001221 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; pfam09819 390333001222 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 390333001223 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 390333001224 ATP-binding site [chemical binding]; other site 390333001225 Sugar specificity; other site 390333001226 Pyrimidine base specificity; other site 390333001227 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 390333001228 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 390333001229 Sugar specificity; other site 390333001230 Pyrimidine base specificity; other site 390333001231 ATP-binding site [chemical binding]; other site 390333001232 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 390333001233 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 390333001234 Walker A/P-loop; other site 390333001235 ATP binding site [chemical binding]; other site 390333001236 Q-loop/lid; other site 390333001237 ABC transporter signature motif; other site 390333001238 Walker B; other site 390333001239 D-loop; other site 390333001240 H-loop/switch region; other site 390333001241 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 390333001242 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 390333001243 substrate binding pocket [chemical binding]; other site 390333001244 membrane-bound complex binding site; other site 390333001245 hinge residues; other site 390333001246 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 390333001247 dimer interface [polypeptide binding]; other site 390333001248 conserved gate region; other site 390333001249 putative PBP binding loops; other site 390333001250 ABC-ATPase subunit interface; other site 390333001251 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 390333001252 dimer interface [polypeptide binding]; other site 390333001253 conserved gate region; other site 390333001254 putative PBP binding loops; other site 390333001255 ABC-ATPase subunit interface; other site 390333001256 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 390333001257 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 390333001258 substrate binding pocket [chemical binding]; other site 390333001259 membrane-bound complex binding site; other site 390333001260 hinge residues; other site 390333001261 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 390333001262 polyphosphate kinase; Provisional; Region: PRK05443 390333001263 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 390333001264 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 390333001265 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 390333001266 putative domain interface [polypeptide binding]; other site 390333001267 putative active site [active] 390333001268 catalytic site [active] 390333001269 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 390333001270 putative domain interface [polypeptide binding]; other site 390333001271 putative active site [active] 390333001272 catalytic site [active] 390333001273 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 390333001274 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 390333001275 substrate binding site [chemical binding]; other site 390333001276 dimer interface [polypeptide binding]; other site 390333001277 ATP binding site [chemical binding]; other site 390333001278 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 390333001279 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 390333001280 substrate binding site [chemical binding]; other site 390333001281 hexamer interface [polypeptide binding]; other site 390333001282 metal binding site [ion binding]; metal-binding site 390333001283 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 390333001284 tetramer (dimer of dimers) interface [polypeptide binding]; other site 390333001285 active site 390333001286 dimer interface [polypeptide binding]; other site 390333001287 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 390333001288 active site 390333001289 tetramer interface [polypeptide binding]; other site 390333001290 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 390333001291 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 390333001292 DNA-binding site [nucleotide binding]; DNA binding site 390333001293 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 390333001294 putative phosphoketolase; Provisional; Region: PRK05261 390333001295 XFP N-terminal domain; Region: XFP_N; pfam09364 390333001296 XFP C-terminal domain; Region: XFP_C; pfam09363 390333001297 Domain of unknown function DUF21; Region: DUF21; pfam01595 390333001298 FOG: CBS domain [General function prediction only]; Region: COG0517 390333001299 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 390333001300 Transporter associated domain; Region: CorC_HlyC; smart01091 390333001301 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 390333001302 active site 390333001303 amino acid transporter; Region: 2A0306; TIGR00909 390333001304 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 390333001305 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 390333001306 active site 390333001307 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 390333001308 DEAD-like helicases superfamily; Region: DEXDc; smart00487 390333001309 ATP binding site [chemical binding]; other site 390333001310 putative Mg++ binding site [ion binding]; other site 390333001311 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 390333001312 nucleotide binding region [chemical binding]; other site 390333001313 ATP-binding site [chemical binding]; other site 390333001314 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 390333001315 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 390333001316 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 390333001317 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 390333001318 uracil transporter; Provisional; Region: PRK10720 390333001319 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 390333001320 Aluminium resistance protein; Region: Alum_res; pfam06838 390333001321 putative ornithine decarboxylase; Region: lacto_ODC_hypo; TIGR04318 390333001322 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 390333001323 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 390333001324 catalytic residue [active] 390333001325 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 390333001326 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 390333001327 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 390333001328 active site 390333001329 homodimer interface [polypeptide binding]; other site 390333001330 Predicted membrane protein [Function unknown]; Region: COG2246 390333001331 GtrA-like protein; Region: GtrA; pfam04138 390333001332 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 390333001333 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 390333001334 methionine aminopeptidase; Provisional; Region: PRK08671 390333001335 active site 390333001336 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 390333001337 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 390333001338 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 390333001339 active site 390333001340 tetramer interface; other site 390333001341 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 390333001342 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 390333001343 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 390333001344 TRAM domain; Region: TRAM; pfam01938 390333001345 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 390333001346 S-adenosylmethionine binding site [chemical binding]; other site 390333001347 recombination regulator RecX; Provisional; Region: recX; PRK14135 390333001348 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 390333001349 Transporter associated domain; Region: CorC_HlyC; pfam03471 390333001350 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 390333001351 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 390333001352 G1 box; other site 390333001353 putative GEF interaction site [polypeptide binding]; other site 390333001354 GTP/Mg2+ binding site [chemical binding]; other site 390333001355 Switch I region; other site 390333001356 G2 box; other site 390333001357 G3 box; other site 390333001358 Switch II region; other site 390333001359 G4 box; other site 390333001360 G5 box; other site 390333001361 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 390333001362 Domain of unknown function (DUF1827); Region: DUF1827; pfam08860 390333001363 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 390333001364 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 390333001365 Walker A motif; other site 390333001366 ATP binding site [chemical binding]; other site 390333001367 Walker B motif; other site 390333001368 arginine finger; other site 390333001369 UvrB/uvrC motif; Region: UVR; pfam02151 390333001370 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 390333001371 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 390333001372 Walker A motif; other site 390333001373 ATP binding site [chemical binding]; other site 390333001374 Walker B motif; other site 390333001375 arginine finger; other site 390333001376 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 390333001377 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 390333001378 dimerization domain swap beta strand [polypeptide binding]; other site 390333001379 regulatory protein interface [polypeptide binding]; other site 390333001380 active site 390333001381 regulatory phosphorylation site [posttranslational modification]; other site 390333001382 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 390333001383 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 390333001384 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 390333001385 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 390333001386 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 390333001387 ArsC family; Region: ArsC; pfam03960 390333001388 putative catalytic residues [active] 390333001389 thiol/disulfide switch; other site 390333001390 adaptor protein; Provisional; Region: PRK02315 390333001391 Thioredoxin; Region: Thioredoxin_5; pfam13743 390333001392 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 390333001393 putative active site [active] 390333001394 putative metal binding residues [ion binding]; other site 390333001395 signature motif; other site 390333001396 putative triphosphate binding site [ion binding]; other site 390333001397 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 390333001398 synthetase active site [active] 390333001399 NTP binding site [chemical binding]; other site 390333001400 metal binding site [ion binding]; metal-binding site 390333001401 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 390333001402 ATP-NAD kinase; Region: NAD_kinase; pfam01513 390333001403 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 390333001404 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 390333001405 active site 390333001406 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 390333001407 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 390333001408 PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; cl01516 390333001409 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 390333001410 Domain of unknown function DUF20; Region: UPF0118; pfam01594 390333001411 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 390333001412 Protein of unknown function (DUF1149); Region: DUF1149; cl11551 390333001413 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 390333001414 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 390333001415 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 390333001416 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 390333001417 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 390333001418 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 390333001419 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 390333001420 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 390333001421 classical (c) SDRs; Region: SDR_c; cd05233 390333001422 NAD(P) binding site [chemical binding]; other site 390333001423 active site 390333001424 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 390333001425 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 390333001426 non-specific DNA binding site [nucleotide binding]; other site 390333001427 salt bridge; other site 390333001428 sequence-specific DNA binding site [nucleotide binding]; other site 390333001429 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 390333001430 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 390333001431 hexamer interface [polypeptide binding]; other site 390333001432 RecA/RadA recombinase [DNA replication, recombination, and repair]; Region: RecA; COG0468 390333001433 Walker A motif; other site 390333001434 ATP binding site [chemical binding]; other site 390333001435 Walker B motif; other site 390333001436 phosphodiesterase; Provisional; Region: PRK12704 390333001437 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 390333001438 Zn2+ binding site [ion binding]; other site 390333001439 Mg2+ binding site [ion binding]; other site 390333001440 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 390333001441 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 390333001442 Mg++ binding site [ion binding]; other site 390333001443 putative catalytic motif [active] 390333001444 substrate binding site [chemical binding]; other site 390333001445 Uncharacterized conserved protein [Function unknown]; Region: COG1739 390333001446 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 390333001447 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 390333001448 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 390333001449 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 390333001450 ATP binding site [chemical binding]; other site 390333001451 putative Mg++ binding site [ion binding]; other site 390333001452 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 390333001453 nucleotide binding region [chemical binding]; other site 390333001454 ATP-binding site [chemical binding]; other site 390333001455 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 390333001456 30S subunit binding site; other site 390333001457 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12906 390333001458 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 390333001459 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 390333001460 nucleotide binding region [chemical binding]; other site 390333001461 ATP-binding site [chemical binding]; other site 390333001462 peptide chain release factor 2; Provisional; Region: PRK05589 390333001463 This domain is found in peptide chain release factors; Region: PCRF; smart00937 390333001464 RF-1 domain; Region: RF-1; pfam00472 390333001465 HPr kinase/phosphorylase; Provisional; Region: PRK05428 390333001466 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 390333001467 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 390333001468 Hpr binding site; other site 390333001469 active site 390333001470 homohexamer subunit interaction site [polypeptide binding]; other site 390333001471 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 390333001472 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 390333001473 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 390333001474 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 390333001475 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 390333001476 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 390333001477 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 390333001478 excinuclease ABC subunit B; Provisional; Region: PRK05298 390333001479 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 390333001480 ATP binding site [chemical binding]; other site 390333001481 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 390333001482 nucleotide binding region [chemical binding]; other site 390333001483 ATP-binding site [chemical binding]; other site 390333001484 Ultra-violet resistance protein B; Region: UvrB; pfam12344 390333001485 UvrB/uvrC motif; Region: UVR; pfam02151 390333001486 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 390333001487 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 390333001488 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 390333001489 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 390333001490 Short repeat of unknown function (DUF308); Region: DUF308; cl15828 390333001491 Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA; cl01007 390333001492 active site 390333001493 metal binding site [ion binding]; metal-binding site 390333001494 homopentamer interface [polypeptide binding]; other site 390333001495 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 390333001496 AAA domain; Region: AAA_18; pfam13238 390333001497 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 390333001498 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 390333001499 phosphate binding site [ion binding]; other site 390333001500 putative substrate binding pocket [chemical binding]; other site 390333001501 dimer interface [polypeptide binding]; other site 390333001502 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 390333001503 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 390333001504 Clp protease; Region: CLP_protease; pfam00574 390333001505 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 390333001506 oligomer interface [polypeptide binding]; other site 390333001507 active site residues [active] 390333001508 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 390333001509 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 390333001510 TM-ABC transporter signature motif; other site 390333001511 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 390333001512 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 390333001513 Walker A/P-loop; other site 390333001514 ATP binding site [chemical binding]; other site 390333001515 Q-loop/lid; other site 390333001516 ABC transporter signature motif; other site 390333001517 Walker B; other site 390333001518 D-loop; other site 390333001519 H-loop/switch region; other site 390333001520 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 390333001521 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 390333001522 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 390333001523 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 390333001524 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 390333001525 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 390333001526 Phosphoglycerate kinase; Region: PGK; pfam00162 390333001527 substrate binding site [chemical binding]; other site 390333001528 hinge regions; other site 390333001529 ADP binding site [chemical binding]; other site 390333001530 catalytic site [active] 390333001531 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 390333001532 triosephosphate isomerase; Provisional; Region: PRK14567 390333001533 substrate binding site [chemical binding]; other site 390333001534 dimer interface [polypeptide binding]; other site 390333001535 catalytic triad [active] 390333001536 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 390333001537 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 390333001538 active site 390333001539 motif I; other site 390333001540 motif II; other site 390333001541 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 390333001542 motif II; other site 390333001543 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 390333001544 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 390333001545 ligand binding site [chemical binding]; other site 390333001546 active site 390333001547 UGI interface [polypeptide binding]; other site 390333001548 catalytic site [active] 390333001549 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 390333001550 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 390333001551 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 390333001552 active site 390333001553 catalytic site [active] 390333001554 substrate binding site [chemical binding]; other site 390333001555 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 390333001556 FAD binding domain; Region: FAD_binding_4; pfam01565 390333001557 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 390333001558 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 390333001559 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 390333001560 Walker A/P-loop; other site 390333001561 ATP binding site [chemical binding]; other site 390333001562 Q-loop/lid; other site 390333001563 ABC transporter signature motif; other site 390333001564 Walker B; other site 390333001565 D-loop; other site 390333001566 H-loop/switch region; other site 390333001567 TOBE domain; Region: TOBE_2; pfam08402 390333001568 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 390333001569 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 390333001570 dimer interface [polypeptide binding]; other site 390333001571 conserved gate region; other site 390333001572 putative PBP binding loops; other site 390333001573 ABC-ATPase subunit interface; other site 390333001574 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 390333001575 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 390333001576 dimer interface [polypeptide binding]; other site 390333001577 conserved gate region; other site 390333001578 ABC-ATPase subunit interface; other site 390333001579 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 390333001580 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 390333001581 Uncharacterized conserved protein [Function unknown]; Region: COG1624 390333001582 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 390333001583 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 390333001584 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 390333001585 active site 390333001586 substrate binding site [chemical binding]; other site 390333001587 metal binding site [ion binding]; metal-binding site 390333001588 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 390333001589 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 390333001590 active site 390333001591 motif I; other site 390333001592 motif II; other site 390333001593 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 390333001594 Penicillinase repressor; Region: Pencillinase_R; pfam03965 390333001595 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 390333001596 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 390333001597 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 390333001598 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 390333001599 motif II; other site 390333001600 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 390333001601 camphor resistance protein CrcB; Provisional; Region: PRK14220 390333001602 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 390333001603 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 390333001604 metal binding site [ion binding]; metal-binding site 390333001605 active site 390333001606 I-site; other site 390333001607 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 390333001608 Low molecular weight phosphatase family; Region: LMWPc; cd00115 390333001609 active site 390333001610 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 390333001611 NADH(P)-binding; Region: NAD_binding_10; pfam13460 390333001612 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 390333001613 Amino acid permease; Region: AA_permease_2; pfam13520 390333001614 methionine sulfoxide reductase A; Provisional; Region: PRK14054 390333001615 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 390333001616 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 390333001617 active site 390333001618 nucleophile elbow; other site 390333001619 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 390333001620 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 390333001621 intersubunit interface [polypeptide binding]; other site 390333001622 Predicted integral membrane protein [Function unknown]; Region: COG5652 390333001623 hypothetical protein; Validated; Region: PRK00110 390333001624 pilus retraction protein PilT; Region: pilT_fam; TIGR01420 390333001625 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 390333001626 Walker A motif; other site 390333001627 ATP binding site [chemical binding]; other site 390333001628 Walker B motif; other site 390333001629 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 390333001630 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 390333001631 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 390333001632 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 390333001633 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 390333001634 S-adenosylmethionine binding site [chemical binding]; other site 390333001635 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 390333001636 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 390333001637 propionate/acetate kinase; Provisional; Region: PRK12379 390333001638 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 390333001639 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 390333001640 active site 390333001641 phosphorylation site [posttranslational modification] 390333001642 intermolecular recognition site; other site 390333001643 dimerization interface [polypeptide binding]; other site 390333001644 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 390333001645 DNA binding site [nucleotide binding] 390333001646 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 390333001647 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 390333001648 dimerization interface [polypeptide binding]; other site 390333001649 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 390333001650 dimer interface [polypeptide binding]; other site 390333001651 phosphorylation site [posttranslational modification] 390333001652 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 390333001653 ATP binding site [chemical binding]; other site 390333001654 Mg2+ binding site [ion binding]; other site 390333001655 G-X-G motif; other site 390333001656 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 390333001657 Sulfatase; Region: Sulfatase; pfam00884 390333001658 VanZ like family; Region: VanZ; pfam04892 390333001659 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 390333001660 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 390333001661 active site 390333001662 dimer interface [polypeptide binding]; other site 390333001663 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 390333001664 dimer interface [polypeptide binding]; other site 390333001665 active site 390333001666 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 390333001667 Beta-lactamase; Region: Beta-lactamase; pfam00144 390333001668 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 390333001669 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 390333001670 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 390333001671 thymidine kinase; Provisional; Region: PRK04296 390333001672 peptide chain release factor 1; Validated; Region: prfA; PRK00591 390333001673 This domain is found in peptide chain release factors; Region: PCRF; smart00937 390333001674 RF-1 domain; Region: RF-1; pfam00472 390333001675 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 390333001676 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 390333001677 S-adenosylmethionine binding site [chemical binding]; other site 390333001678 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 390333001679 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 390333001680 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 390333001681 active site 390333001682 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 390333001683 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 390333001684 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 390333001685 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 390333001686 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 390333001687 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 390333001688 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 390333001689 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 390333001690 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 390333001691 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 390333001692 beta subunit interaction interface [polypeptide binding]; other site 390333001693 Walker A motif; other site 390333001694 ATP binding site [chemical binding]; other site 390333001695 Walker B motif; other site 390333001696 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 390333001697 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 390333001698 core domain interface [polypeptide binding]; other site 390333001699 delta subunit interface [polypeptide binding]; other site 390333001700 epsilon subunit interface [polypeptide binding]; other site 390333001701 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 390333001702 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 390333001703 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 390333001704 alpha subunit interaction interface [polypeptide binding]; other site 390333001705 Walker A motif; other site 390333001706 ATP binding site [chemical binding]; other site 390333001707 Walker B motif; other site 390333001708 inhibitor binding site; inhibition site 390333001709 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 390333001710 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 390333001711 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 390333001712 gamma subunit interface [polypeptide binding]; other site 390333001713 epsilon subunit interface [polypeptide binding]; other site 390333001714 LBP interface [polypeptide binding]; other site 390333001715 Protein of unknown function (DUF1146); Region: DUF1146; pfam06612 390333001716 rod shape-determining protein MreB; Provisional; Region: PRK13930 390333001717 MreB and similar proteins; Region: MreB_like; cd10225 390333001718 nucleotide binding site [chemical binding]; other site 390333001719 Mg binding site [ion binding]; other site 390333001720 putative protofilament interaction site [polypeptide binding]; other site 390333001721 RodZ interaction site [polypeptide binding]; other site 390333001722 hypothetical protein; Provisional; Region: PRK14379 390333001723 Protein of unknown function (DUF2969); Region: DUF2969; pfam11184 390333001724 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 390333001725 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 390333001726 Ligand Binding Site [chemical binding]; other site 390333001727 recombination factor protein RarA; Reviewed; Region: PRK13342 390333001728 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 390333001729 Walker A motif; other site 390333001730 ATP binding site [chemical binding]; other site 390333001731 Walker B motif; other site 390333001732 arginine finger; other site 390333001733 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 390333001734 Protein of unknown function (DUF1694); Region: DUF1694; pfam07997 390333001735 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 390333001736 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 390333001737 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 390333001738 RNA binding surface [nucleotide binding]; other site 390333001739 Septation ring formation regulator, EzrA; Region: EzrA; pfam06160 390333001740 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 390333001741 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 390333001742 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 390333001743 catalytic residue [active] 390333001744 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 390333001745 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 390333001746 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 390333001747 Ligand Binding Site [chemical binding]; other site 390333001748 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 390333001749 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 390333001750 RNA binding surface [nucleotide binding]; other site 390333001751 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 390333001752 active site 390333001753 uracil binding [chemical binding]; other site 390333001754 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 390333001755 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 390333001756 active site 390333001757 HIGH motif; other site 390333001758 nucleotide binding site [chemical binding]; other site 390333001759 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 390333001760 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 390333001761 active site 390333001762 KMSKS motif; other site 390333001763 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 390333001764 tRNA binding surface [nucleotide binding]; other site 390333001765 anticodon binding site; other site 390333001766 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 390333001767 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 390333001768 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 390333001769 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 390333001770 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 390333001771 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 390333001772 motif II; other site 390333001773 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 390333001774 MPN+ (JAMM) motif; other site 390333001775 Zinc-binding site [ion binding]; other site 390333001776 rod shape-determining protein MreB; Provisional; Region: PRK13927 390333001777 MreB and similar proteins; Region: MreB_like; cd10225 390333001778 nucleotide binding site [chemical binding]; other site 390333001779 Mg binding site [ion binding]; other site 390333001780 putative protofilament interaction site [polypeptide binding]; other site 390333001781 RodZ interaction site [polypeptide binding]; other site 390333001782 rod shape-determining protein MreC; Provisional; Region: PRK13922 390333001783 Protein of unknown function (DUF904); Region: DUF904; pfam06005 390333001784 rod shape-determining protein MreC; Region: MreC; pfam04085 390333001785 rod shape-determining protein MreD; Region: shape_MreD; TIGR03426 390333001786 cell division protein MraZ; Reviewed; Region: PRK00326 390333001787 MraZ protein; Region: MraZ; pfam02381 390333001788 MraZ protein; Region: MraZ; pfam02381 390333001789 MraW methylase family; Region: Methyltransf_5; pfam01795 390333001790 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 390333001791 cell division protein FtsL; Region: ftsL_broad; TIGR02209 390333001792 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 390333001793 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 390333001794 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 390333001795 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 390333001796 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 390333001797 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 390333001798 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 390333001799 Mg++ binding site [ion binding]; other site 390333001800 putative catalytic motif [active] 390333001801 putative substrate binding site [chemical binding]; other site 390333001802 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 390333001803 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 390333001804 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 390333001805 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 390333001806 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 390333001807 active site 390333001808 homodimer interface [polypeptide binding]; other site 390333001809 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 390333001810 Cell division protein FtsQ; Region: FtsQ; pfam03799 390333001811 cell division protein FtsA; Region: ftsA; TIGR01174 390333001812 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 390333001813 nucleotide binding site [chemical binding]; other site 390333001814 Cell division protein FtsA; Region: FtsA; cl17206 390333001815 Cell division protein FtsA; Region: FtsA; pfam14450 390333001816 cell division protein FtsZ; Validated; Region: PRK09330 390333001817 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 390333001818 nucleotide binding site [chemical binding]; other site 390333001819 SulA interaction site; other site 390333001820 Protein of unknown function (DUF552); Region: DUF552; cl00775 390333001821 YGGT family; Region: YGGT; pfam02325 390333001822 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 390333001823 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 390333001824 RNA binding surface [nucleotide binding]; other site 390333001825 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 390333001826 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 390333001827 active site 390333001828 HIGH motif; other site 390333001829 nucleotide binding site [chemical binding]; other site 390333001830 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 390333001831 active site 390333001832 KMSKS motif; other site 390333001833 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 390333001834 tRNA binding surface [nucleotide binding]; other site 390333001835 anticodon binding site; other site 390333001836 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 390333001837 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 390333001838 DNA-binding site [nucleotide binding]; DNA binding site 390333001839 RNA-binding motif; other site 390333001840 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 390333001841 dimer interface [polypeptide binding]; other site 390333001842 ADP-ribose binding site [chemical binding]; other site 390333001843 active site 390333001844 nudix motif; other site 390333001845 metal binding site [ion binding]; metal-binding site 390333001846 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 390333001847 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 390333001848 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 390333001849 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 390333001850 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 390333001851 catalytic residue [active] 390333001852 Putative amino acid metabolism; Region: DUF1831; pfam08866 390333001853 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 390333001854 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 390333001855 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 390333001856 catalytic core [active] 390333001857 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 390333001858 binding surface 390333001859 TPR motif; other site 390333001860 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 390333001861 AAA domain; Region: AAA_30; pfam13604 390333001862 Family description; Region: UvrD_C_2; pfam13538 390333001863 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK07251 390333001864 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 390333001865 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 390333001866 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 390333001867 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 390333001868 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 390333001869 hypothetical protein; Provisional; Region: PRK13667 390333001870 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 390333001871 active site 390333001872 catalytic residues [active] 390333001873 metal binding site [ion binding]; metal-binding site 390333001874 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 390333001875 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 390333001876 putative GEF interaction site [polypeptide binding]; other site 390333001877 G1 box; other site 390333001878 GTP/Mg2+ binding site [chemical binding]; other site 390333001879 Switch I region; other site 390333001880 G2 box; other site 390333001881 G3 box; other site 390333001882 Switch II region; other site 390333001883 G4 box; other site 390333001884 G5 box; other site 390333001885 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 390333001886 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 390333001887 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 390333001888 Uncharacterized protein conserved in bacteria (DUF2129); Region: DUF2129; pfam09902 390333001889 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 390333001890 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 390333001891 S-adenosylmethionine binding site [chemical binding]; other site 390333001892 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 390333001893 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 390333001894 active site 390333001895 (T/H)XGH motif; other site 390333001896 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 390333001897 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 390333001898 SLBB domain; Region: SLBB; pfam10531 390333001899 Helix-hairpin-helix motif; Region: HHH; pfam00633 390333001900 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 390333001901 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 390333001902 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 390333001903 Competence protein; Region: Competence; pfam03772 390333001904 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 390333001905 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 390333001906 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 390333001907 DNA polymerase III, delta subunit; Region: holA; TIGR01128 390333001908 StaR_like; a well-conserved protein found in bacteria, plants, and animals. A family member from Streptomyces toyocaensis, StaR is part of a gene cluster involved in the biosynthesis of glycopeptide antibiotics (GPAs), specifically A47934. It has been...; Region: StaR_like; cd05804 390333001909 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 390333001910 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 390333001911 16S/18S rRNA binding site [nucleotide binding]; other site 390333001912 S13e-L30e interaction site [polypeptide binding]; other site 390333001913 25S rRNA binding site [nucleotide binding]; other site 390333001914 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 390333001915 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 390333001916 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 390333001917 GIY-YIG motif/motif A; other site 390333001918 active site 390333001919 catalytic site [active] 390333001920 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 390333001921 elongation factor Tu; Reviewed; Region: PRK00049 390333001922 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 390333001923 G1 box; other site 390333001924 GEF interaction site [polypeptide binding]; other site 390333001925 GTP/Mg2+ binding site [chemical binding]; other site 390333001926 Switch I region; other site 390333001927 G2 box; other site 390333001928 G3 box; other site 390333001929 Switch II region; other site 390333001930 G4 box; other site 390333001931 G5 box; other site 390333001932 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 390333001933 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 390333001934 Antibiotic Binding Site [chemical binding]; other site 390333001935 trigger factor; Provisional; Region: tig; PRK01490 390333001936 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 390333001937 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 390333001938 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 390333001939 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 390333001940 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 390333001941 Walker A motif; other site 390333001942 ATP binding site [chemical binding]; other site 390333001943 Walker B motif; other site 390333001944 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 390333001945 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 390333001946 G1 box; other site 390333001947 GTP/Mg2+ binding site [chemical binding]; other site 390333001948 Switch I region; other site 390333001949 G2 box; other site 390333001950 G3 box; other site 390333001951 Switch II region; other site 390333001952 G4 box; other site 390333001953 G5 box; other site 390333001954 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 390333001955 FMN binding site [chemical binding]; other site 390333001956 dimer interface [polypeptide binding]; other site 390333001957 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 390333001958 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 390333001959 peptide binding site [polypeptide binding]; other site 390333001960 ABC transporter C family member; Provisional; Region: PLN03232 390333001961 thymidylate synthase; Region: thym_sym; TIGR03284 390333001962 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 390333001963 dimerization interface [polypeptide binding]; other site 390333001964 active site 390333001965 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 390333001966 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 390333001967 folate binding site [chemical binding]; other site 390333001968 NADP+ binding site [chemical binding]; other site 390333001969 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 390333001970 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 390333001971 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 390333001972 Walker A/P-loop; other site 390333001973 ATP binding site [chemical binding]; other site 390333001974 Q-loop/lid; other site 390333001975 ABC transporter signature motif; other site 390333001976 Walker B; other site 390333001977 D-loop; other site 390333001978 H-loop/switch region; other site 390333001979 NIL domain; Region: NIL; pfam09383 390333001980 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 390333001981 dimer interface [polypeptide binding]; other site 390333001982 conserved gate region; other site 390333001983 ABC-ATPase subunit interface; other site 390333001984 L-aspartate oxidase; Provisional; Region: PRK06175 390333001985 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 390333001986 L-aspartate oxidase; Provisional; Region: PRK06175 390333001987 Transposase; Region: DEDD_Tnp_IS110; pfam01548 390333001988 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 390333001989 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 390333001990 similar to hypothetical protein; This sequence makes part of ISL4 390333001991 similar to hypothetical protein; This sequence makes part of ISL4 390333001992 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 390333001993 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 390333001994 pyridoxal 5'-phosphate binding site [chemical binding]; other site 390333001995 homodimer interface [polypeptide binding]; other site 390333001996 catalytic residue [active] 390333001997 Transcriptional regulator [Transcription]; Region: LysR; COG0583 390333001998 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 390333001999 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 390333002000 dimerization interface [polypeptide binding]; other site 390333002001 arginyl-tRNA synthetase; Reviewed; Region: PRK12451 390333002002 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 390333002003 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 390333002004 active site 390333002005 HIGH motif; other site 390333002006 KMSK motif region; other site 390333002007 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 390333002008 tRNA binding surface [nucleotide binding]; other site 390333002009 anticodon binding site; other site 390333002010 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 390333002011 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 390333002012 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 390333002013 Flavoprotein; Region: Flavoprotein; pfam02441 390333002014 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 390333002015 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 390333002016 Amidohydrolase; Region: Amidohydro_2; pfam04909 390333002017 Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_13; cd12178 390333002018 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 390333002019 putative ligand binding site [chemical binding]; other site 390333002020 putative NAD binding site [chemical binding]; other site 390333002021 catalytic site [active] 390333002022 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 390333002023 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 390333002024 ATP binding site [chemical binding]; other site 390333002025 putative Mg++ binding site [ion binding]; other site 390333002026 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 390333002027 nucleotide binding region [chemical binding]; other site 390333002028 ATP-binding site [chemical binding]; other site 390333002029 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 390333002030 HRDC domain; Region: HRDC; pfam00570 390333002031 nuc_hydro_ TvIAG: Nucleoside hydrolases similar to the Inosine-adenosine-guanosine-preferring nucleoside hydrolase from Trypanosoma vivax. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base; Region: nuc_hydro_TvIAG; cd02647 390333002032 active site 390333002033 dimerization interface [polypeptide binding]; other site 390333002034 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 390333002035 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 390333002036 GIY-YIG motif/motif A; other site 390333002037 active site 390333002038 catalytic site [active] 390333002039 putative DNA binding site [nucleotide binding]; other site 390333002040 metal binding site [ion binding]; metal-binding site 390333002041 UvrB/uvrC motif; Region: UVR; pfam02151 390333002042 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 390333002043 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 390333002044 DNA binding site [nucleotide binding] 390333002045 GTPase CgtA; Reviewed; Region: obgE; PRK12297 390333002046 GTP1/OBG; Region: GTP1_OBG; pfam01018 390333002047 Obg GTPase; Region: Obg; cd01898 390333002048 G1 box; other site 390333002049 GTP/Mg2+ binding site [chemical binding]; other site 390333002050 Switch I region; other site 390333002051 G2 box; other site 390333002052 G3 box; other site 390333002053 Switch II region; other site 390333002054 G4 box; other site 390333002055 G5 box; other site 390333002056 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 390333002057 ribonuclease Z; Region: RNase_Z; TIGR02651 390333002058 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 390333002059 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 390333002060 NAD(P) binding site [chemical binding]; other site 390333002061 active site 390333002062 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 390333002063 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 390333002064 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 390333002065 active site 390333002066 metal binding site [ion binding]; metal-binding site 390333002067 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 390333002068 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 390333002069 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 390333002070 nucleotide binding region [chemical binding]; other site 390333002071 ATP-binding site [chemical binding]; other site 390333002072 hypothetical protein; Provisional; Region: PRK13690 390333002073 similar to hypothetical protein; This sequence makes part of ISL4 390333002074 similar to hypothetical protein; This sequence makes part of ISL4 390333002075 Transposase; Region: DEDD_Tnp_IS110; pfam01548 390333002076 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 390333002077 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 390333002078 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 390333002079 DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587 390333002080 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 390333002081 active site 390333002082 PHP Thumb interface [polypeptide binding]; other site 390333002083 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 390333002084 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 390333002085 active site 390333002086 ADP/pyrophosphate binding site [chemical binding]; other site 390333002087 dimerization interface [polypeptide binding]; other site 390333002088 allosteric effector site; other site 390333002089 fructose-1,6-bisphosphate binding site; other site 390333002090 pyruvate kinase; Provisional; Region: PRK06354 390333002091 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 390333002092 domain interfaces; other site 390333002093 active site 390333002094 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 390333002095 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 390333002096 S1 domain; Region: S1_2; pfam13509 390333002097 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 390333002098 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 390333002099 active site 390333002100 Int/Topo IB signature motif; other site 390333002101 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 390333002102 segregation and condensation protein B; Reviewed; Region: scpB; PRK00135 390333002103 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 390333002104 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 390333002105 RNA binding surface [nucleotide binding]; other site 390333002106 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 390333002107 active site 390333002108 Predicted membrane protein [Function unknown]; Region: COG3601 390333002109 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 390333002110 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 390333002111 cytidylate kinase; Provisional; Region: cmk; PRK00023 390333002112 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 390333002113 CMP-binding site; other site 390333002114 The sites determining sugar specificity; other site 390333002115 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 390333002116 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 390333002117 RNA binding site [nucleotide binding]; other site 390333002118 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 390333002119 RNA binding site [nucleotide binding]; other site 390333002120 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 390333002121 RNA binding site [nucleotide binding]; other site 390333002122 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 390333002123 RNA binding site [nucleotide binding]; other site 390333002124 GTP-binding protein Der; Reviewed; Region: PRK00093 390333002125 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 390333002126 G1 box; other site 390333002127 GTP/Mg2+ binding site [chemical binding]; other site 390333002128 Switch I region; other site 390333002129 G2 box; other site 390333002130 Switch II region; other site 390333002131 G3 box; other site 390333002132 G4 box; other site 390333002133 G5 box; other site 390333002134 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 390333002135 G1 box; other site 390333002136 GTP/Mg2+ binding site [chemical binding]; other site 390333002137 Switch I region; other site 390333002138 G2 box; other site 390333002139 G3 box; other site 390333002140 Switch II region; other site 390333002141 G4 box; other site 390333002142 G5 box; other site 390333002143 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 390333002144 IHF dimer interface [polypeptide binding]; other site 390333002145 IHF - DNA interface [nucleotide binding]; other site 390333002146 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 390333002147 binding surface 390333002148 TPR motif; other site 390333002149 TPR repeat; Region: TPR_11; pfam13414 390333002150 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 390333002151 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 390333002152 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 390333002153 Transcriptional regulator [Transcription]; Region: LysR; COG0583 390333002154 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 390333002155 dimerization interface [polypeptide binding]; other site 390333002156 helicase Cas3; Provisional; Region: PRK09694 390333002157 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 390333002158 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 390333002159 CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cd09729 390333002160 CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cd09731 390333002161 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-E; cl09608 390333002162 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 390333002163 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cd09756 390333002164 CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09727 390333002165 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-E; cd09719 390333002166 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I-E; cd09755 390333002167 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 390333002168 active site 390333002169 catalytic site [active] 390333002170 substrate binding site [chemical binding]; other site 390333002171 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 390333002172 synthetase active site [active] 390333002173 NTP binding site [chemical binding]; other site 390333002174 metal binding site [ion binding]; metal-binding site 390333002175 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 390333002176 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 390333002177 active site 390333002178 phosphorylation site [posttranslational modification] 390333002179 intermolecular recognition site; other site 390333002180 dimerization interface [polypeptide binding]; other site 390333002181 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 390333002182 DNA binding site [nucleotide binding] 390333002183 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 390333002184 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 390333002185 dimer interface [polypeptide binding]; other site 390333002186 phosphorylation site [posttranslational modification] 390333002187 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 390333002188 ATP binding site [chemical binding]; other site 390333002189 Mg2+ binding site [ion binding]; other site 390333002190 G-X-G motif; other site 390333002191 putative acyltransferase; Provisional; Region: PRK05790 390333002192 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 390333002193 dimer interface [polypeptide binding]; other site 390333002194 active site 390333002195 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 390333002196 homodimer interface [polypeptide binding]; other site 390333002197 catalytic residues [active] 390333002198 NAD binding site [chemical binding]; other site 390333002199 substrate binding pocket [chemical binding]; other site 390333002200 flexible flap; other site 390333002201 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 390333002202 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 390333002203 dimer interface [polypeptide binding]; other site 390333002204 active site 390333002205 Uncharacterized conserved protein [Function unknown]; Region: COG2966 390333002206 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 390333002207 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 390333002208 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 390333002209 putative deacylase active site [active] 390333002210 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 390333002211 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 390333002212 S-adenosylmethionine binding site [chemical binding]; other site 390333002213 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 390333002214 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 390333002215 Zn2+ binding site [ion binding]; other site 390333002216 Mg2+ binding site [ion binding]; other site 390333002217 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 390333002218 synthetase active site [active] 390333002219 NTP binding site [chemical binding]; other site 390333002220 metal binding site [ion binding]; metal-binding site 390333002221 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 390333002222 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 390333002223 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 390333002224 putative active site [active] 390333002225 dimerization interface [polypeptide binding]; other site 390333002226 putative tRNAtyr binding site [nucleotide binding]; other site 390333002227 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 390333002228 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 390333002229 dimer interface [polypeptide binding]; other site 390333002230 motif 1; other site 390333002231 active site 390333002232 motif 2; other site 390333002233 motif 3; other site 390333002234 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 390333002235 anticodon binding site; other site 390333002236 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 390333002237 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 390333002238 dimer interface [polypeptide binding]; other site 390333002239 anticodon binding site; other site 390333002240 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 390333002241 homodimer interface [polypeptide binding]; other site 390333002242 motif 1; other site 390333002243 active site 390333002244 motif 2; other site 390333002245 GAD domain; Region: GAD; pfam02938 390333002246 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 390333002247 active site 390333002248 motif 3; other site 390333002249 similar to hypothetical protein; This sequence makes part of ISL4 390333002250 similar to hypothetical protein; This sequence makes part of ISL4 390333002251 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 390333002252 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 390333002253 Domain of unknown function DUF20; Region: UPF0118; pfam01594 390333002254 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 390333002255 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 390333002256 dimer interface [polypeptide binding]; other site 390333002257 active site 390333002258 CoA binding pocket [chemical binding]; other site 390333002259 acyl carrier protein; Provisional; Region: acpP; PRK00982 390333002260 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 390333002261 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 390333002262 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 390333002263 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 390333002264 NAD(P) binding site [chemical binding]; other site 390333002265 active site 390333002266 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 390333002267 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 390333002268 dimer interface [polypeptide binding]; other site 390333002269 active site 390333002270 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 390333002271 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 390333002272 carboxyltransferase (CT) interaction site; other site 390333002273 biotinylation site [posttranslational modification]; other site 390333002274 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 390333002275 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 390333002276 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 390333002277 ATP-grasp domain; Region: ATP-grasp_4; cl17255 390333002278 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 390333002279 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 390333002280 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 390333002281 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 390333002282 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK06079 390333002283 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 390333002284 NAD binding site [chemical binding]; other site 390333002285 homotetramer interface [polypeptide binding]; other site 390333002286 homodimer interface [polypeptide binding]; other site 390333002287 substrate binding site [chemical binding]; other site 390333002288 active site 390333002289 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 390333002290 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 390333002291 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 390333002292 Domain of Unknown Function with PDB structure (DUF3862); Region: DUF3862; pfam12978 390333002293 similar to hypothetical protein; This sequence makes part of ISL4 390333002294 similar to hypothetical protein; This sequence makes part of ISL4 390333002295 Transposase; Region: DEDD_Tnp_IS110; pfam01548 390333002296 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 390333002297 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 390333002298 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 390333002299 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 390333002300 PBP superfamily domain; Region: PBP_like_2; cl17296 390333002301 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 390333002302 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 390333002303 dimer interface [polypeptide binding]; other site 390333002304 conserved gate region; other site 390333002305 putative PBP binding loops; other site 390333002306 ABC-ATPase subunit interface; other site 390333002307 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 390333002308 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 390333002309 dimer interface [polypeptide binding]; other site 390333002310 conserved gate region; other site 390333002311 putative PBP binding loops; other site 390333002312 ABC-ATPase subunit interface; other site 390333002313 phosphate transporter ATP-binding protein; Provisional; Region: PRK14240 390333002314 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 390333002315 Walker A/P-loop; other site 390333002316 ATP binding site [chemical binding]; other site 390333002317 Q-loop/lid; other site 390333002318 ABC transporter signature motif; other site 390333002319 Walker B; other site 390333002320 D-loop; other site 390333002321 H-loop/switch region; other site 390333002322 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 390333002323 PhoU domain; Region: PhoU; pfam01895 390333002324 PhoU domain; Region: PhoU; pfam01895 390333002325 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 390333002326 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 390333002327 dimer interface [polypeptide binding]; other site 390333002328 phosphorylation site [posttranslational modification] 390333002329 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 390333002330 ATP binding site [chemical binding]; other site 390333002331 Mg2+ binding site [ion binding]; other site 390333002332 G-X-G motif; other site 390333002333 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 390333002334 dimer interface [polypeptide binding]; other site 390333002335 ADP-ribose binding site [chemical binding]; other site 390333002336 active site 390333002337 nudix motif; other site 390333002338 metal binding site [ion binding]; metal-binding site 390333002339 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 390333002340 active site 390333002341 isopentenyl-diphosphate delta-isomerase, type 1; Region: IPP_isom_1; TIGR02150 390333002342 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_33; cd04692 390333002343 nudix motif; other site 390333002344 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 390333002345 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 390333002346 Walker A/P-loop; other site 390333002347 ATP binding site [chemical binding]; other site 390333002348 Q-loop/lid; other site 390333002349 ABC transporter signature motif; other site 390333002350 Walker B; other site 390333002351 D-loop; other site 390333002352 H-loop/switch region; other site 390333002353 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 390333002354 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 390333002355 Walker A/P-loop; other site 390333002356 ATP binding site [chemical binding]; other site 390333002357 Q-loop/lid; other site 390333002358 ABC transporter signature motif; other site 390333002359 Walker B; other site 390333002360 D-loop; other site 390333002361 H-loop/switch region; other site 390333002362 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 390333002363 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 390333002364 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 390333002365 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 390333002366 metal binding site [ion binding]; metal-binding site 390333002367 active site 390333002368 I-site; other site 390333002369 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 390333002370 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 390333002371 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 390333002372 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 390333002373 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 390333002374 Mg2+ binding site [ion binding]; other site 390333002375 G-X-G motif; other site 390333002376 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 390333002377 anchoring element; other site 390333002378 dimer interface [polypeptide binding]; other site 390333002379 ATP binding site [chemical binding]; other site 390333002380 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 390333002381 active site 390333002382 putative metal-binding site [ion binding]; other site 390333002383 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 390333002384 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 390333002385 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 390333002386 CAP-like domain; other site 390333002387 active site 390333002388 primary dimer interface [polypeptide binding]; other site 390333002389 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 390333002390 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 390333002391 DHH family; Region: DHH; pfam01368 390333002392 DHHA2 domain; Region: DHHA2; pfam02833 390333002393 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 390333002394 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 390333002395 homotetramer interface [polypeptide binding]; other site 390333002396 FMN binding site [chemical binding]; other site 390333002397 homodimer contacts [polypeptide binding]; other site 390333002398 putative active site [active] 390333002399 putative substrate binding site [chemical binding]; other site 390333002400 phosphomevalonate kinase, ERG8-type, Gram-positive branch; Region: Pmev_kin_Gr_pos; TIGR01220 390333002401 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 390333002402 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 390333002403 Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407 390333002404 diphosphomevalonate decarboxylase; Region: PLN02407 390333002405 Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577 390333002406 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 390333002407 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 390333002408 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 390333002409 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 390333002410 DEAD/DEAH box helicase; Region: DEAD; pfam00270 390333002411 Family description; Region: UvrD_C_2; pfam13538 390333002412 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 390333002413 DnaQ family exonuclease/DinG family helicase, putative; Region: dinG_rel; TIGR01407 390333002414 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 390333002415 active site 390333002416 catalytic site [active] 390333002417 substrate binding site [chemical binding]; other site 390333002418 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 390333002419 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 390333002420 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 390333002421 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 390333002422 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 390333002423 putative dimer interface [polypeptide binding]; other site 390333002424 putative anticodon binding site; other site 390333002425 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 390333002426 homodimer interface [polypeptide binding]; other site 390333002427 motif 1; other site 390333002428 motif 2; other site 390333002429 active site 390333002430 motif 3; other site 390333002431 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 390333002432 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 390333002433 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 390333002434 endonuclease III; Region: ENDO3c; smart00478 390333002435 minor groove reading motif; other site 390333002436 helix-hairpin-helix signature motif; other site 390333002437 substrate binding pocket [chemical binding]; other site 390333002438 active site 390333002439 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 390333002440 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 390333002441 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 390333002442 D-lactate dehydrogenase; Validated; Region: PRK08605 390333002443 D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186 390333002444 homodimer interface [polypeptide binding]; other site 390333002445 ligand binding site [chemical binding]; other site 390333002446 NAD binding site [chemical binding]; other site 390333002447 catalytic site [active] 390333002448 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 390333002449 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 390333002450 Transglycosylase; Region: Transgly; pfam00912 390333002451 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 390333002452 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 390333002453 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 390333002454 hypothetical protein; Provisional; Region: PRK13660 390333002455 DivIVA protein; Region: DivIVA; pfam05103 390333002456 DivIVA domain; Region: DivI1A_domain; TIGR03544 390333002457 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 390333002458 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 390333002459 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 390333002460 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 390333002461 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 390333002462 Potassium binding sites [ion binding]; other site 390333002463 Cesium cation binding sites [ion binding]; other site 390333002464 lipoprotein signal peptidase; Provisional; Region: PRK14797 390333002465 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 390333002466 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 390333002467 RNA binding surface [nucleotide binding]; other site 390333002468 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 390333002469 active site 390333002470 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12838 390333002471 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 390333002472 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 390333002473 catalytic site [active] 390333002474 subunit interface [polypeptide binding]; other site 390333002475 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK12815 390333002476 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 390333002477 ATP-grasp domain; Region: ATP-grasp_4; cl17255 390333002478 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 390333002479 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 390333002480 ATP-grasp domain; Region: ATP-grasp_4; cl17255 390333002481 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 390333002482 IMP binding site; other site 390333002483 dimer interface [polypeptide binding]; other site 390333002484 interdomain contacts; other site 390333002485 partial ornithine binding site; other site 390333002486 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 390333002487 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 390333002488 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 390333002489 Domain of unknown function (DUF814); Region: DUF814; pfam05670 390333002490 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 390333002491 EamA-like transporter family; Region: EamA; pfam00892 390333002492 EamA-like transporter family; Region: EamA; pfam00892 390333002493 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 390333002494 catalytic core [active] 390333002495 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 390333002496 FMN binding site [chemical binding]; other site 390333002497 dimer interface [polypeptide binding]; other site 390333002498 site-specific tyrosine recombinase XerS; Reviewed; Region: xerS; PRK05084 390333002499 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 390333002500 active site 390333002501 DNA binding site [nucleotide binding] 390333002502 Int/Topo IB signature motif; other site 390333002503 glycerate kinase; Region: TIGR00045 390333002504 Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; cl01811 390333002505 TPR repeat; Region: TPR_11; pfam13414 390333002506 Sel1-like repeats; Region: SEL1; smart00671 390333002507 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 390333002508 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 390333002509 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 390333002510 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 390333002511 ATP binding site [chemical binding]; other site 390333002512 putative Mg++ binding site [ion binding]; other site 390333002513 HsdM N-terminal domain; Region: HsdM_N; pfam12161 390333002514 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 390333002515 Methyltransferase domain; Region: Methyltransf_26; pfam13659 390333002516 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 390333002517 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 390333002518 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 390333002519 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 390333002520 Homeodomain leucine-zipper encoding, Homez; Region: Homez; pfam11569 390333002521 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 390333002522 Int/Topo IB signature motif; other site 390333002523 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 390333002524 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 390333002525 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 390333002526 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 390333002527 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 390333002528 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 390333002529 peptide binding site [polypeptide binding]; other site 390333002530 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12838 390333002531 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 390333002532 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 390333002533 catalytic site [active] 390333002534 subunit interface [polypeptide binding]; other site 390333002535 putative efflux protein, MATE family; Region: matE; TIGR00797 390333002536 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 390333002537 Helix-Turn-Helix DNA binding domain of the BltR transcription regulator; Region: HTH_BltR; cd04782 390333002538 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 390333002539 DNA binding residues [nucleotide binding] 390333002540 dimer interface [polypeptide binding]; other site 390333002541 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 390333002542 active site 390333002543 DNA binding site [nucleotide binding] 390333002544 Int/Topo IB signature motif; other site 390333002545 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 390333002546 Low molecular weight phosphatase family; Region: LMWPc; cd00115 390333002547 active site 390333002548 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 390333002549 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 390333002550 Walker A/P-loop; other site 390333002551 ATP binding site [chemical binding]; other site 390333002552 Q-loop/lid; other site 390333002553 ABC transporter signature motif; other site 390333002554 Walker B; other site 390333002555 D-loop; other site 390333002556 H-loop/switch region; other site 390333002557 similar to hypothetical protein 390333002558 hypothetical protein; Validated; Region: PRK07121 390333002559 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 390333002560 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 390333002561 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 390333002562 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 390333002563 active site 390333002564 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 390333002565 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 390333002566 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 390333002567 hypothetical protein; Validated; Region: PRK07121 390333002568 similar to hypothetical protein 390333002569 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 390333002570 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 390333002571 Walker A/P-loop; other site 390333002572 ATP binding site [chemical binding]; other site 390333002573 Q-loop/lid; other site 390333002574 ABC transporter signature motif; other site 390333002575 Walker B; other site 390333002576 D-loop; other site 390333002577 H-loop/switch region; other site 390333002578 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 390333002579 Low molecular weight phosphatase family; Region: LMWPc; cd00115 390333002580 active site 390333002581 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 390333002582 active site 390333002583 DNA binding site [nucleotide binding] 390333002584 Int/Topo IB signature motif; other site 390333002585 Helix-Turn-Helix DNA binding domain of the BltR transcription regulator; Region: HTH_BltR; cd04782 390333002586 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 390333002587 DNA binding residues [nucleotide binding] 390333002588 dimer interface [polypeptide binding]; other site 390333002589 putative efflux protein, MATE family; Region: matE; TIGR00797 390333002590 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 390333002591 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12838 390333002592 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 390333002593 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 390333002594 catalytic site [active] 390333002595 subunit interface [polypeptide binding]; other site 390333002596 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 390333002597 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_1; cd12161 390333002598 putative ligand binding site [chemical binding]; other site 390333002599 putative NAD binding site [chemical binding]; other site 390333002600 catalytic site [active] 390333002601 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 390333002602 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 390333002603 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 390333002604 Walker A/P-loop; other site 390333002605 ATP binding site [chemical binding]; other site 390333002606 Q-loop/lid; other site 390333002607 ABC transporter signature motif; other site 390333002608 Walker B; other site 390333002609 D-loop; other site 390333002610 H-loop/switch region; other site 390333002611 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 390333002612 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 390333002613 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 390333002614 Walker A/P-loop; other site 390333002615 ATP binding site [chemical binding]; other site 390333002616 Q-loop/lid; other site 390333002617 ABC transporter signature motif; other site 390333002618 Walker B; other site 390333002619 D-loop; other site 390333002620 H-loop/switch region; other site 390333002621 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 390333002622 active site residue [active] 390333002623 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 390333002624 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 390333002625 catalytic residues [active] 390333002626 Caulimovirus viroplasmin; Region: Cauli_VI; pfam01693 390333002627 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 390333002628 Coenzyme A binding pocket [chemical binding]; other site 390333002629 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 390333002630 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 390333002631 motif II; other site 390333002632 LytTr DNA-binding domain; Region: LytTR; smart00850 390333002633 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 390333002634 active site 390333002635 catalytic site [active] 390333002636 substrate binding site [chemical binding]; other site 390333002637 Protein of unknown function (DUF419); Region: DUF419; pfam04237 390333002638 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cl00630 390333002639 putative active site [active] 390333002640 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 390333002641 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 390333002642 Coenzyme A binding pocket [chemical binding]; other site 390333002643 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 390333002644 putative dimer interface [polypeptide binding]; other site 390333002645 catalytic triad [active] 390333002646 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 390333002647 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 390333002648 S-adenosylmethionine binding site [chemical binding]; other site 390333002649 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 390333002650 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 390333002651 putative substrate binding pocket [chemical binding]; other site 390333002652 AC domain interface; other site 390333002653 catalytic triad [active] 390333002654 AB domain interface; other site 390333002655 interchain disulfide; other site 390333002656 Protease prsW family; Region: PrsW-protease; pfam13367 390333002657 NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082 390333002658 NADP-dependent glyceraldehyde-3-phosphate dehydrogenase; Provisional; Region: PLN00412 390333002659 tetrameric interface [polypeptide binding]; other site 390333002660 activator binding site; other site 390333002661 NADP binding site [chemical binding]; other site 390333002662 substrate binding site [chemical binding]; other site 390333002663 catalytic residues [active] 390333002664 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 390333002665 dimer interface [polypeptide binding]; other site 390333002666 conserved gate region; other site 390333002667 putative PBP binding loops; other site 390333002668 ABC-ATPase subunit interface; other site 390333002669 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 390333002670 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 390333002671 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 390333002672 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 390333002673 Walker A/P-loop; other site 390333002674 ATP binding site [chemical binding]; other site 390333002675 Q-loop/lid; other site 390333002676 ABC transporter signature motif; other site 390333002677 Walker B; other site 390333002678 D-loop; other site 390333002679 H-loop/switch region; other site 390333002680 Predicted transcriptional regulator [Transcription]; Region: COG1959 390333002681 Transcriptional regulator; Region: Rrf2; pfam02082 390333002682 Peptidase family M48; Region: Peptidase_M48; cl12018 390333002683 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 390333002684 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 390333002685 pyridoxal 5'-phosphate binding site [chemical binding]; other site 390333002686 homodimer interface [polypeptide binding]; other site 390333002687 catalytic residue [active] 390333002688 Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475 390333002689 putative active site [active] 390333002690 catalytic triad [active] 390333002691 PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133 390333002692 putative integrin binding motif; other site 390333002693 PA/protease domain interface [polypeptide binding]; other site 390333002694 Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475 390333002695 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 390333002696 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 390333002697 Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174 390333002698 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 390333002699 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 390333002700 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 390333002701 dimer interface [polypeptide binding]; other site 390333002702 active site 390333002703 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 390333002704 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 390333002705 putative dimer interface [polypeptide binding]; other site 390333002706 putative anticodon binding site; other site 390333002707 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 390333002708 homodimer interface [polypeptide binding]; other site 390333002709 motif 1; other site 390333002710 motif 2; other site 390333002711 active site 390333002712 motif 3; other site 390333002713 beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525 390333002714 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 390333002715 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 390333002716 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 390333002717 CARDB; Region: CARDB; pfam07705 390333002718 Beta galactosidase small chain; Region: Bgal_small_N; smart01038 390333002719 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 390333002720 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 390333002721 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 390333002722 HPr interaction site; other site 390333002723 glycerol kinase (GK) interaction site [polypeptide binding]; other site 390333002724 active site 390333002725 phosphorylation site [posttranslational modification] 390333002726 similar to hypothetical protein; This sequence makes part of ISL4 390333002727 similar to hypothetical protein; This sequence makes part of ISL4 390333002728 Transposase; Region: DEDD_Tnp_IS110; pfam01548 390333002729 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 390333002730 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 390333002731 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 390333002732 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 390333002733 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 390333002734 Catalytic site [active] 390333002735 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 390333002736 peptidase T; Region: peptidase-T; TIGR01882 390333002737 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 390333002738 metal binding site [ion binding]; metal-binding site 390333002739 dimer interface [polypeptide binding]; other site 390333002740 Uncharacterized conserved protein [Function unknown]; Region: COG0327 390333002741 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 390333002742 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 390333002743 Family of unknown function (DUF633); Region: DUF633; pfam04816 390333002744 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 390333002745 putative active site [active] 390333002746 nucleotide binding site [chemical binding]; other site 390333002747 nudix motif; other site 390333002748 putative metal binding site [ion binding]; other site 390333002749 Peptidase family M23; Region: Peptidase_M23; pfam01551 390333002750 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 390333002751 DNA methylase; Region: N6_N4_Mtase; pfam01555 390333002752 DNA methylase; Region: N6_N4_Mtase; cl17433 390333002753 Domain of unknown function (DUF4391); Region: DUF4391; pfam14335 390333002754 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_c; cd10311 390333002755 putative active site [active] 390333002756 catalytic site [active] 390333002757 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 390333002758 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 390333002759 ATP binding site [chemical binding]; other site 390333002760 putative Mg++ binding site [ion binding]; other site 390333002761 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 390333002762 nucleotide binding region [chemical binding]; other site 390333002763 ATP-binding site [chemical binding]; other site 390333002764 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 390333002765 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 390333002766 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 390333002767 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 390333002768 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 390333002769 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 390333002770 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 390333002771 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 390333002772 DNA binding residues [nucleotide binding] 390333002773 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 390333002774 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 390333002775 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 390333002776 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 390333002777 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 390333002778 DNA binding residues [nucleotide binding] 390333002779 DNA primase; Validated; Region: dnaG; PRK05667 390333002780 CHC2 zinc finger; Region: zf-CHC2; pfam01807 390333002781 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 390333002782 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 390333002783 active site 390333002784 metal binding site [ion binding]; metal-binding site 390333002785 interdomain interaction site; other site 390333002786 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 390333002787 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 390333002788 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 390333002789 glycyl-tRNA synthetase subunit alpha; Validated; Region: glyQ; PRK09348 390333002790 motif 1; other site 390333002791 dimer interface [polypeptide binding]; other site 390333002792 active site 390333002793 motif 2; other site 390333002794 motif 3; other site 390333002795 DNA repair protein RecO; Region: reco; TIGR00613 390333002796 Recombination protein O N terminal; Region: RecO_N; pfam11967 390333002797 Recombination protein O C terminal; Region: RecO_C; pfam02565 390333002798 GTPase Era; Reviewed; Region: era; PRK00089 390333002799 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 390333002800 G1 box; other site 390333002801 GTP/Mg2+ binding site [chemical binding]; other site 390333002802 Switch I region; other site 390333002803 G2 box; other site 390333002804 Switch II region; other site 390333002805 G3 box; other site 390333002806 G4 box; other site 390333002807 G5 box; other site 390333002808 KH domain; Region: KH_2; pfam07650 390333002809 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 390333002810 active site 390333002811 catalytic motif [active] 390333002812 Zn binding site [ion binding]; other site 390333002813 metal-binding heat shock protein; Provisional; Region: PRK00016 390333002814 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 390333002815 PhoH-like protein; Region: PhoH; pfam02562 390333002816 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 390333002817 Kinase/pyrophosphorylase; Region: Kinase-PPPase; pfam03618 390333002818 Uncharacterized conserved protein [Function unknown]; Region: COG1284 390333002819 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 390333002820 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 390333002821 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 390333002822 aromatic amino acid aminotransferase; Validated; Region: PRK07309 390333002823 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 390333002824 pyridoxal 5'-phosphate binding site [chemical binding]; other site 390333002825 homodimer interface [polypeptide binding]; other site 390333002826 catalytic residue [active] 390333002827 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 390333002828 active site 390333002829 catalytic residues [active] 390333002830 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 390333002831 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 390333002832 Walker A motif; other site 390333002833 ATP binding site [chemical binding]; other site 390333002834 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 390333002835 Walker B motif; other site 390333002836 arginine finger; other site 390333002837 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 390333002838 ATP-dependent protease subunit HslV; Provisional; Region: PRK05456 390333002839 active site 390333002840 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 390333002841 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 390333002842 active site 390333002843 DNA binding site [nucleotide binding] 390333002844 Int/Topo IB signature motif; other site 390333002845 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 390333002846 Glucose inhibited division protein A; Region: GIDA; pfam01134 390333002847 DNA topoisomerase I; Validated; Region: PRK05582 390333002848 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 390333002849 active site 390333002850 interdomain interaction site; other site 390333002851 putative metal-binding site [ion binding]; other site 390333002852 nucleotide binding site [chemical binding]; other site 390333002853 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 390333002854 domain I; other site 390333002855 DNA binding groove [nucleotide binding] 390333002856 phosphate binding site [ion binding]; other site 390333002857 domain II; other site 390333002858 domain III; other site 390333002859 nucleotide binding site [chemical binding]; other site 390333002860 catalytic site [active] 390333002861 domain IV; other site 390333002862 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 390333002863 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 390333002864 DNA protecting protein DprA; Region: dprA; TIGR00732 390333002865 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 390333002866 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 390333002867 RNA/DNA hybrid binding site [nucleotide binding]; other site 390333002868 active site 390333002869 ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596 390333002870 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 390333002871 GTP/Mg2+ binding site [chemical binding]; other site 390333002872 G4 box; other site 390333002873 G5 box; other site 390333002874 G1 box; other site 390333002875 Switch I region; other site 390333002876 G2 box; other site 390333002877 G3 box; other site 390333002878 Switch II region; other site 390333002879 hypothetical protein; Provisional; Region: PRK13672 390333002880 EDD domain protein, DegV family; Region: DegV; TIGR00762 390333002881 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 390333002882 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 390333002883 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 390333002884 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 390333002885 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 390333002886 active site 390333002887 NTP binding site [chemical binding]; other site 390333002888 metal binding triad [ion binding]; metal-binding site 390333002889 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 390333002890 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 390333002891 Uncharacterized conserved protein [Function unknown]; Region: COG1284 390333002892 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 390333002893 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 390333002894 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 390333002895 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290 390333002896 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 390333002897 nucleotidyl binding site; other site 390333002898 metal binding site [ion binding]; metal-binding site 390333002899 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 390333002900 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 390333002901 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 390333002902 Walker A/P-loop; other site 390333002903 ATP binding site [chemical binding]; other site 390333002904 Q-loop/lid; other site 390333002905 ABC transporter signature motif; other site 390333002906 Walker B; other site 390333002907 D-loop; other site 390333002908 H-loop/switch region; other site 390333002909 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 390333002910 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 390333002911 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 390333002912 Walker A/P-loop; other site 390333002913 ATP binding site [chemical binding]; other site 390333002914 Q-loop/lid; other site 390333002915 ABC transporter signature motif; other site 390333002916 Walker B; other site 390333002917 D-loop; other site 390333002918 H-loop/switch region; other site 390333002919 Transcriptional regulator [Transcription]; Region: LysR; COG0583 390333002920 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 390333002921 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 390333002922 dimerization interface [polypeptide binding]; other site 390333002923 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 390333002924 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 390333002925 active site 390333002926 EDD domain protein, DegV family; Region: DegV; TIGR00762 390333002927 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 390333002928 enolase; Provisional; Region: eno; PRK00077 390333002929 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 390333002930 dimer interface [polypeptide binding]; other site 390333002931 metal binding site [ion binding]; metal-binding site 390333002932 substrate binding pocket [chemical binding]; other site 390333002933 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 390333002934 Bacterial protein of unknown function (DUF898); Region: DUF898; cl01738 390333002935 Protein of unknown function (DUF4230); Region: DUF4230; pfam14014 390333002936 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 390333002937 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 390333002938 Walker A/P-loop; other site 390333002939 ATP binding site [chemical binding]; other site 390333002940 Q-loop/lid; other site 390333002941 ABC transporter signature motif; other site 390333002942 Walker B; other site 390333002943 D-loop; other site 390333002944 H-loop/switch region; other site 390333002945 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 390333002946 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 390333002947 substrate binding pocket [chemical binding]; other site 390333002948 membrane-bound complex binding site; other site 390333002949 hinge residues; other site 390333002950 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 390333002951 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 390333002952 dimer interface [polypeptide binding]; other site 390333002953 conserved gate region; other site 390333002954 putative PBP binding loops; other site 390333002955 ABC-ATPase subunit interface; other site 390333002956 Transcriptional regulator [Transcription]; Region: LysR; COG0583 390333002957 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 390333002958 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 390333002959 dimerization interface [polypeptide binding]; other site 390333002960 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 390333002961 plasma-membrane proton-efflux P-type ATPase; Region: ATPase-IIIA_H; TIGR01647 390333002962 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 390333002963 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 390333002964 motif I; other site 390333002965 motif II; other site 390333002966 Domain of unknown function DUF20; Region: UPF0118; pfam01594 390333002967 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 390333002968 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 390333002969 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 390333002970 homodimer interface [polypeptide binding]; other site 390333002971 substrate-cofactor binding pocket; other site 390333002972 catalytic residue [active] 390333002973 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 390333002974 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 390333002975 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 390333002976 dimerization interface [polypeptide binding]; other site 390333002977 putative DNA binding site [nucleotide binding]; other site 390333002978 putative Zn2+ binding site [ion binding]; other site 390333002979 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 390333002980 active site 390333002981 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 390333002982 DHH family; Region: DHH; pfam01368 390333002983 DHHA1 domain; Region: DHHA1; pfam02272 390333002984 Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; cl11538 390333002985 Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165 390333002986 active site 390333002987 catalytic site [active] 390333002988 GTP-binding protein LepA; Provisional; Region: PRK05433 390333002989 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 390333002990 G1 box; other site 390333002991 putative GEF interaction site [polypeptide binding]; other site 390333002992 GTP/Mg2+ binding site [chemical binding]; other site 390333002993 Switch I region; other site 390333002994 G2 box; other site 390333002995 G3 box; other site 390333002996 Switch II region; other site 390333002997 G4 box; other site 390333002998 G5 box; other site 390333002999 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 390333003000 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 390333003001 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 390333003002 chaperone protein DnaJ; Provisional; Region: PRK14276 390333003003 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 390333003004 HSP70 interaction site [polypeptide binding]; other site 390333003005 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 390333003006 substrate binding site [polypeptide binding]; other site 390333003007 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 390333003008 Zn binding sites [ion binding]; other site 390333003009 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 390333003010 dimer interface [polypeptide binding]; other site 390333003011 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 390333003012 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 390333003013 nucleotide binding site [chemical binding]; other site 390333003014 NEF interaction site [polypeptide binding]; other site 390333003015 SBD interface [polypeptide binding]; other site 390333003016 GrpE; Region: GrpE; pfam01025 390333003017 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 390333003018 dimer interface [polypeptide binding]; other site 390333003019 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 390333003020 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 390333003021 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 390333003022 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 390333003023 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 390333003024 active site 390333003025 Riboflavin kinase; Region: Flavokinase; smart00904 390333003026 Transposase; Region: DEDD_Tnp_IS110; pfam01548 390333003027 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 390333003028 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 390333003029 similar to hypothetical protein; This sequence makes part of ISL4 390333003030 similar to hypothetical protein; This sequence makes part of ISL4 390333003031 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 390333003032 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 390333003033 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 390333003034 dimer interface [polypeptide binding]; other site 390333003035 pyridoxal 5'-phosphate binding site [chemical binding]; other site 390333003036 catalytic residue [active] 390333003037 cystathionine beta-lyase; Provisional; Region: PRK07671 390333003038 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 390333003039 homodimer interface [polypeptide binding]; other site 390333003040 substrate-cofactor binding pocket; other site 390333003041 pyridoxal 5'-phosphate binding site [chemical binding]; other site 390333003042 catalytic residue [active] 390333003043 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK02484 390333003044 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 390333003045 RNA binding site [nucleotide binding]; other site 390333003046 active site 390333003047 ribosome-binding factor A; Provisional; Region: PRK13818 390333003048 translation initiation factor IF-2; Validated; Region: infB; PRK05306 390333003049 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 390333003050 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 390333003051 G1 box; other site 390333003052 putative GEF interaction site [polypeptide binding]; other site 390333003053 GTP/Mg2+ binding site [chemical binding]; other site 390333003054 Switch I region; other site 390333003055 G2 box; other site 390333003056 G3 box; other site 390333003057 Switch II region; other site 390333003058 G4 box; other site 390333003059 G5 box; other site 390333003060 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 390333003061 Translation-initiation factor 2; Region: IF-2; pfam11987 390333003062 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 390333003063 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 390333003064 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 390333003065 putative RNA binding cleft [nucleotide binding]; other site 390333003066 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 390333003067 NusA N-terminal domain; Region: NusA_N; pfam08529 390333003068 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 390333003069 RNA binding site [nucleotide binding]; other site 390333003070 homodimer interface [polypeptide binding]; other site 390333003071 NusA-like KH domain; Region: KH_5; pfam13184 390333003072 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 390333003073 G-X-X-G motif; other site 390333003074 ribosome maturation protein RimP; Reviewed; Region: PRK00092 390333003075 Sm and related proteins; Region: Sm_like; cl00259 390333003076 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 390333003077 putative oligomer interface [polypeptide binding]; other site 390333003078 putative RNA binding site [nucleotide binding]; other site 390333003079 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 390333003080 DNA polymerase III PolC; Validated; Region: polC; PRK00448 390333003081 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 390333003082 generic binding surface II; other site 390333003083 generic binding surface I; other site 390333003084 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 390333003085 active site 390333003086 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 390333003087 active site 390333003088 catalytic site [active] 390333003089 substrate binding site [chemical binding]; other site 390333003090 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 390333003091 prolyl-tRNA synthetase; Provisional; Region: PRK09194 390333003092 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 390333003093 dimer interface [polypeptide binding]; other site 390333003094 motif 1; other site 390333003095 active site 390333003096 motif 2; other site 390333003097 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 390333003098 putative deacylase active site [active] 390333003099 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 390333003100 active site 390333003101 motif 3; other site 390333003102 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 390333003103 anticodon binding site; other site 390333003104 RIP metalloprotease RseP; Region: TIGR00054 390333003105 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 390333003106 active site 390333003107 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 390333003108 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 390333003109 protein binding site [polypeptide binding]; other site 390333003110 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 390333003111 putative substrate binding region [chemical binding]; other site 390333003112 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 390333003113 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 390333003114 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 390333003115 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 390333003116 catalytic residue [active] 390333003117 putative FPP diphosphate binding site; other site 390333003118 putative FPP binding hydrophobic cleft; other site 390333003119 dimer interface [polypeptide binding]; other site 390333003120 putative IPP diphosphate binding site; other site 390333003121 ribosome recycling factor; Reviewed; Region: frr; PRK00083 390333003122 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 390333003123 hinge region; other site 390333003124 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 390333003125 putative nucleotide binding site [chemical binding]; other site 390333003126 uridine monophosphate binding site [chemical binding]; other site 390333003127 homohexameric interface [polypeptide binding]; other site 390333003128 elongation factor Ts; Provisional; Region: tsf; PRK09377 390333003129 Elongation factor TS; Region: EF_TS; pfam00889 390333003130 Elongation factor TS; Region: EF_TS; pfam00889 390333003131 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 390333003132 rRNA interaction site [nucleotide binding]; other site 390333003133 S8 interaction site; other site 390333003134 putative laminin-1 binding site; other site 390333003135 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 390333003136 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 390333003137 S-adenosylmethionine binding site [chemical binding]; other site 390333003138 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 390333003139 GIY-YIG motif/motif A; other site 390333003140 putative active site [active] 390333003141 putative metal binding site [ion binding]; other site 390333003142 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 390333003143 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 390333003144 putative acyl-acceptor binding pocket; other site 390333003145 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 390333003146 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 390333003147 aspartate kinase; Reviewed; Region: PRK09034 390333003148 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 390333003149 putative catalytic residues [active] 390333003150 putative nucleotide binding site [chemical binding]; other site 390333003151 putative aspartate binding site [chemical binding]; other site 390333003152 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 390333003153 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 390333003154 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 390333003155 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 390333003156 hypothetical protein; Provisional; Region: PRK04435 390333003157 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 390333003158 DNA-binding interface [nucleotide binding]; DNA binding site 390333003159 C-terminal ACT domain of a small (; 147 a.a.) putative phenylalanine biosynthetic pathway protein described in Bacillus subtilis (BS) PheB (PheB-BS) and related domains; Region: ACT_PheB-BS; cd04888 390333003160 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 390333003161 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 390333003162 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 390333003163 Walker A/P-loop; other site 390333003164 ATP binding site [chemical binding]; other site 390333003165 Q-loop/lid; other site 390333003166 ABC transporter signature motif; other site 390333003167 Walker B; other site 390333003168 D-loop; other site 390333003169 H-loop/switch region; other site 390333003170 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 390333003171 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 390333003172 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 390333003173 Walker A/P-loop; other site 390333003174 ATP binding site [chemical binding]; other site 390333003175 Q-loop/lid; other site 390333003176 ABC transporter signature motif; other site 390333003177 Walker B; other site 390333003178 D-loop; other site 390333003179 H-loop/switch region; other site 390333003180 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3763 390333003181 Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979 390333003182 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 390333003183 putative DNA binding site [nucleotide binding]; other site 390333003184 LexA repressor; Validated; Region: PRK00215 390333003185 putative Zn2+ binding site [ion binding]; other site 390333003186 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 390333003187 Catalytic site [active] 390333003188 Sugar transport protein; Region: Sugar_transport; pfam06800 390333003189 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 390333003190 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 390333003191 substrate binding pocket [chemical binding]; other site 390333003192 membrane-bound complex binding site; other site 390333003193 hinge residues; other site 390333003194 CRISPR-associated helicase Cas3, subtype CYANO; Region: cas3_cyano; TIGR03158 390333003195 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 390333003196 ATP binding site [chemical binding]; other site 390333003197 putative Mg++ binding site [ion binding]; other site 390333003198 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 390333003199 nucleotide binding region [chemical binding]; other site 390333003200 ATP-binding site [chemical binding]; other site 390333003201 P-loop Domain of unknown function (DUF2791); Region: DUF2791; pfam10923 390333003202 AAA ATPase domain; Region: AAA_16; pfam13191 390333003203 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 390333003204 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 390333003205 putative active site [active] 390333003206 putative metal binding site [ion binding]; other site 390333003207 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 390333003208 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 390333003209 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 390333003210 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 390333003211 RimM N-terminal domain; Region: RimM; pfam01782 390333003212 PRC-barrel domain; Region: PRC; pfam05239 390333003213 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 390333003214 signal recognition particle protein; Provisional; Region: PRK10867 390333003215 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 390333003216 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 390333003217 P loop; other site 390333003218 GTP binding site [chemical binding]; other site 390333003219 Signal peptide binding domain; Region: SRP_SPB; pfam02978 390333003220 putative DNA-binding protein; Validated; Region: PRK00118 390333003221 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 390333003222 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 390333003223 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 390333003224 P loop; other site 390333003225 GTP binding site [chemical binding]; other site 390333003226 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 390333003227 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 390333003228 Walker A/P-loop; other site 390333003229 ATP binding site [chemical binding]; other site 390333003230 Q-loop/lid; other site 390333003231 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 390333003232 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 390333003233 ABC transporter signature motif; other site 390333003234 Walker B; other site 390333003235 D-loop; other site 390333003236 H-loop/switch region; other site 390333003237 ribonuclease III; Reviewed; Region: rnc; PRK00102 390333003238 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 390333003239 dimerization interface [polypeptide binding]; other site 390333003240 active site 390333003241 metal binding site [ion binding]; metal-binding site 390333003242 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 390333003243 dsRNA binding site [nucleotide binding]; other site 390333003244 The substrate binding component of an ABC-type lactococcal OppA-like transport system contains; Region: PBP2_Lactococcal_OppA_like; cd08510 390333003245 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 390333003246 peptide binding site [polypeptide binding]; other site 390333003247 The substrate binding component of an ABC-type lactococcal OppA-like transport system contains; Region: PBP2_Lactococcal_OppA_like; cd08510 390333003248 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 390333003249 peptide binding site [polypeptide binding]; other site 390333003250 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 390333003251 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 390333003252 dimer interface [polypeptide binding]; other site 390333003253 conserved gate region; other site 390333003254 putative PBP binding loops; other site 390333003255 ABC-ATPase subunit interface; other site 390333003256 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 390333003257 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 390333003258 dimer interface [polypeptide binding]; other site 390333003259 conserved gate region; other site 390333003260 putative PBP binding loops; other site 390333003261 ABC-ATPase subunit interface; other site 390333003262 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 390333003263 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 390333003264 Walker A/P-loop; other site 390333003265 ATP binding site [chemical binding]; other site 390333003266 Q-loop/lid; other site 390333003267 ABC transporter signature motif; other site 390333003268 Walker B; other site 390333003269 D-loop; other site 390333003270 H-loop/switch region; other site 390333003271 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 390333003272 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 390333003273 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 390333003274 Walker A/P-loop; other site 390333003275 ATP binding site [chemical binding]; other site 390333003276 Q-loop/lid; other site 390333003277 ABC transporter signature motif; other site 390333003278 Walker B; other site 390333003279 D-loop; other site 390333003280 H-loop/switch region; other site 390333003281 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 390333003282 acyl carrier protein; Provisional; Region: acpP; PRK00982 390333003283 putative phosphate acyltransferase; Provisional; Region: PRK05331 390333003284 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 390333003285 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 390333003286 ssDNA binding site; other site 390333003287 generic binding surface II; other site 390333003288 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 390333003289 ATP binding site [chemical binding]; other site 390333003290 putative Mg++ binding site [ion binding]; other site 390333003291 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 390333003292 nucleotide binding region [chemical binding]; other site 390333003293 ATP-binding site [chemical binding]; other site 390333003294 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 390333003295 DAK2 domain; Region: Dak2; pfam02734 390333003296 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 390333003297 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 390333003298 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 390333003299 Helix-turn-helix domain; Region: HTH_38; pfam13936 390333003300 Integrase core domain; Region: rve; pfam00665 390333003301 Uncharacterized conserved protein [Function unknown]; Region: COG4127 390333003302 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 390333003303 Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564 390333003304 Thiamine pyrophosphokinase; Region: TPK; cd07995 390333003305 active site 390333003306 dimerization interface [polypeptide binding]; other site 390333003307 thiamine binding site [chemical binding]; other site 390333003308 GTPase RsgA; Reviewed; Region: PRK00098 390333003309 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 390333003310 RNA binding site [nucleotide binding]; other site 390333003311 homodimer interface [polypeptide binding]; other site 390333003312 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 390333003313 GTPase/Zn-binding domain interface [polypeptide binding]; other site 390333003314 GTP/Mg2+ binding site [chemical binding]; other site 390333003315 G4 box; other site 390333003316 G1 box; other site 390333003317 Switch I region; other site 390333003318 G2 box; other site 390333003319 G3 box; other site 390333003320 Switch II region; other site 390333003321 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 390333003322 Catalytic domain of Protein Kinases; Region: PKc; cd00180 390333003323 active site 390333003324 ATP binding site [chemical binding]; other site 390333003325 substrate binding site [chemical binding]; other site 390333003326 activation loop (A-loop); other site 390333003327 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 390333003328 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 390333003329 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 390333003330 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 390333003331 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 390333003332 active site 390333003333 16S rRNA methyltransferase B; Provisional; Region: PRK14902 390333003334 NusB family; Region: NusB; pfam01029 390333003335 putative RNA binding site [nucleotide binding]; other site 390333003336 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 390333003337 S-adenosylmethionine binding site [chemical binding]; other site 390333003338 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 390333003339 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 390333003340 substrate binding site [chemical binding]; other site 390333003341 putative active site [active] 390333003342 putative cosubstrate binding site; other site 390333003343 catalytic site [active] 390333003344 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 390333003345 substrate binding site [chemical binding]; other site 390333003346 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 390333003347 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 390333003348 ATP binding site [chemical binding]; other site 390333003349 putative Mg++ binding site [ion binding]; other site 390333003350 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 390333003351 nucleotide binding region [chemical binding]; other site 390333003352 ATP-binding site [chemical binding]; other site 390333003353 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 390333003354 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 390333003355 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 390333003356 catalytic site [active] 390333003357 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 390333003358 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 390333003359 Walker A/P-loop; other site 390333003360 ATP binding site [chemical binding]; other site 390333003361 Q-loop/lid; other site 390333003362 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 390333003363 ABC transporter signature motif; other site 390333003364 Walker B; other site 390333003365 D-loop; other site 390333003366 H-loop/switch region; other site 390333003367 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 390333003368 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 390333003369 RNA binding surface [nucleotide binding]; other site 390333003370 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 390333003371 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 390333003372 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 390333003373 substrate binding pocket [chemical binding]; other site 390333003374 chain length determination region; other site 390333003375 substrate-Mg2+ binding site; other site 390333003376 catalytic residues [active] 390333003377 aspartate-rich region 1; other site 390333003378 active site lid residues [active] 390333003379 aspartate-rich region 2; other site 390333003380 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 390333003381 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 390333003382 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 390333003383 generic binding surface II; other site 390333003384 generic binding surface I; other site 390333003385 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 390333003386 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 390333003387 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 390333003388 homodimer interface [polypeptide binding]; other site 390333003389 NADP binding site [chemical binding]; other site 390333003390 substrate binding site [chemical binding]; other site 390333003391 transcription antitermination factor NusB; Region: nusB; TIGR01951 390333003392 putative RNA binding site [nucleotide binding]; other site 390333003393 Asp23 family; Region: Asp23; pfam03780 390333003394 elongation factor P; Validated; Region: PRK00529 390333003395 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 390333003396 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 390333003397 RNA binding site [nucleotide binding]; other site 390333003398 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 390333003399 RNA binding site [nucleotide binding]; other site 390333003400 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 390333003401 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 390333003402 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 390333003403 active site 390333003404 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 390333003405 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 390333003406 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 390333003407 ArsC family; Region: ArsC; pfam03960 390333003408 putative ArsC-like catalytic residues; other site 390333003409 putative TRX-like catalytic residues [active] 390333003410 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 390333003411 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 390333003412 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 390333003413 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 390333003414 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 390333003415 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 390333003416 purine monophosphate binding site [chemical binding]; other site 390333003417 dimer interface [polypeptide binding]; other site 390333003418 putative catalytic residues [active] 390333003419 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 390333003420 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 390333003421 Folate-dependent phosphoribosylglycinamide formyltransferase PurN [Nucleotide transport and metabolism]; Region: PurN; COG0299 390333003422 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 390333003423 active site 390333003424 substrate binding site [chemical binding]; other site 390333003425 cosubstrate binding site; other site 390333003426 catalytic site [active] 390333003427 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 390333003428 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 390333003429 dimerization interface [polypeptide binding]; other site 390333003430 putative ATP binding site [chemical binding]; other site 390333003431 amidophosphoribosyltransferase; Provisional; Region: PRK07272 390333003432 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 390333003433 active site 390333003434 tetramer interface [polypeptide binding]; other site 390333003435 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 390333003436 active site 390333003437 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 390333003438 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 390333003439 dimerization interface [polypeptide binding]; other site 390333003440 ATP binding site [chemical binding]; other site 390333003441 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 390333003442 dimerization interface [polypeptide binding]; other site 390333003443 ATP binding site [chemical binding]; other site 390333003444 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 390333003445 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 390333003446 putative active site [active] 390333003447 catalytic triad [active] 390333003448 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700 390333003449 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 390333003450 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 390333003451 ATP binding site [chemical binding]; other site 390333003452 active site 390333003453 substrate binding site [chemical binding]; other site 390333003454 adenylosuccinate lyase; Provisional; Region: PRK07492 390333003455 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 390333003456 tetramer interface [polypeptide binding]; other site 390333003457 active site 390333003458 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 390333003459 ATP-grasp domain; Region: ATP-grasp; pfam02222 390333003460 AIR carboxylase; Region: AIRC; pfam00731 390333003461 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; pfam09860 390333003462 Major Facilitator Superfamily; Region: MFS_1; pfam07690 390333003463 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 390333003464 putative substrate translocation pore; other site 390333003465 x-prolyl-dipeptidyl aminopeptidase; Provisional; Region: PRK05371 390333003466 X-Prolyl dipeptidyl aminopeptidase PepX, N-terminal; Region: PepX_N; smart00940 390333003467 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 390333003468 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 390333003469 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 390333003470 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 390333003471 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 390333003472 dimer interface [polypeptide binding]; other site 390333003473 pyridoxal 5'-phosphate binding site [chemical binding]; other site 390333003474 catalytic residue [active] 390333003475 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 390333003476 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 390333003477 S-adenosylmethionine binding site [chemical binding]; other site 390333003478 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 390333003479 adenosine deaminase; Provisional; Region: PRK09358 390333003480 active site 390333003481 The HIRAN protein (HIP116, Rad5p N-terminal) is found in the N-terminal regions of the SWI2/SNF2 proteins typified by HIP116 and Rad5p; Region: HIRAN; smart00910 390333003482 Transposase; Region: DEDD_Tnp_IS110; pfam01548 390333003483 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 390333003484 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 390333003485 similar to hypothetical protein; This sequence makes part of ISL4 390333003486 similar to hypothetical protein; This sequence makes part of ISL4 390333003487 Domain of unknown function DUF1828; Region: DUF1828; pfam08861 390333003488 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 390333003489 Major Facilitator Superfamily; Region: MFS_1; pfam07690 390333003490 putative substrate translocation pore; other site 390333003491 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 390333003492 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 390333003493 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 390333003494 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 390333003495 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 390333003496 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 390333003497 active site residue [active] 390333003498 Bacterial protein of unknown function (DUF910); Region: DUF910; pfam06014 390333003499 Rhomboid family; Region: Rhomboid; pfam01694 390333003500 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 390333003501 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 390333003502 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 390333003503 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 390333003504 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 390333003505 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 390333003506 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 390333003507 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 390333003508 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 390333003509 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 390333003510 putative tRNA-binding site [nucleotide binding]; other site 390333003511 B3/4 domain; Region: B3_4; pfam03483 390333003512 tRNA synthetase B5 domain; Region: B5; smart00874 390333003513 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 390333003514 dimer interface [polypeptide binding]; other site 390333003515 motif 1; other site 390333003516 motif 3; other site 390333003517 motif 2; other site 390333003518 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 390333003519 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 390333003520 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 390333003521 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 390333003522 dimer interface [polypeptide binding]; other site 390333003523 motif 1; other site 390333003524 active site 390333003525 motif 2; other site 390333003526 motif 3; other site 390333003527 Predicted transcriptional regulators [Transcription]; Region: COG1733 390333003528 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 390333003529 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 390333003530 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 390333003531 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 390333003532 Acylphosphatase; Region: Acylphosphatase; pfam00708 390333003533 OxaA-like protein precursor; Provisional; Region: PRK02463 390333003534 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 390333003535 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 390333003536 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 390333003537 dimerization interface [polypeptide binding]; other site 390333003538 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 390333003539 dimer interface [polypeptide binding]; other site 390333003540 phosphorylation site [posttranslational modification] 390333003541 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 390333003542 ATP binding site [chemical binding]; other site 390333003543 Mg2+ binding site [ion binding]; other site 390333003544 G-X-G motif; other site 390333003545 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 390333003546 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 390333003547 active site 390333003548 phosphorylation site [posttranslational modification] 390333003549 intermolecular recognition site; other site 390333003550 dimerization interface [polypeptide binding]; other site 390333003551 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 390333003552 DNA binding site [nucleotide binding] 390333003553 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 390333003554 hypothetical protein; Provisional; Region: PRK13670 390333003555 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673 390333003556 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 390333003557 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 390333003558 Zn2+ binding site [ion binding]; other site 390333003559 Mg2+ binding site [ion binding]; other site 390333003560 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 390333003561 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 390333003562 active site 390333003563 (T/H)XGH motif; other site 390333003564 GTPase YqeH; Provisional; Region: PRK13796 390333003565 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 390333003566 GTP/Mg2+ binding site [chemical binding]; other site 390333003567 G4 box; other site 390333003568 G5 box; other site 390333003569 G1 box; other site 390333003570 Switch I region; other site 390333003571 G2 box; other site 390333003572 G3 box; other site 390333003573 Switch II region; other site 390333003574 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 390333003575 23S rRNA binding site [nucleotide binding]; other site 390333003576 L21 binding site [polypeptide binding]; other site 390333003577 L13 binding site [polypeptide binding]; other site 390333003578 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 390333003579 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 390333003580 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 390333003581 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 390333003582 Archaeal ATPase; Region: Arch_ATPase; pfam01637 390333003583 AAA ATPase domain; Region: AAA_16; pfam13191 390333003584 Archaea bacterial proteins of unknown function; Region: DUF234; pfam03008 390333003585 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 390333003586 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 390333003587 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 390333003588 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 390333003589 active site 390333003590 dimer interface [polypeptide binding]; other site 390333003591 motif 1; other site 390333003592 motif 2; other site 390333003593 motif 3; other site 390333003594 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 390333003595 anticodon binding site; other site 390333003596 primosomal protein DnaI; Reviewed; Region: PRK08939 390333003597 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 390333003598 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 390333003599 Walker A motif; other site 390333003600 ATP binding site [chemical binding]; other site 390333003601 Walker B motif; other site 390333003602 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 390333003603 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 390333003604 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 390333003605 ATP cone domain; Region: ATP-cone; pfam03477 390333003606 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 390333003607 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 390333003608 CoA-binding site [chemical binding]; other site 390333003609 ATP-binding [chemical binding]; other site 390333003610 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 390333003611 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 390333003612 DNA binding site [nucleotide binding] 390333003613 catalytic residue [active] 390333003614 H2TH interface [polypeptide binding]; other site 390333003615 putative catalytic residues [active] 390333003616 turnover-facilitating residue; other site 390333003617 intercalation triad [nucleotide binding]; other site 390333003618 8OG recognition residue [nucleotide binding]; other site 390333003619 putative reading head residues; other site 390333003620 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 390333003621 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 390333003622 DNA polymerase I; Provisional; Region: PRK05755 390333003623 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 390333003624 active site 390333003625 metal binding site 1 [ion binding]; metal-binding site 390333003626 putative 5' ssDNA interaction site; other site 390333003627 metal binding site 3; metal-binding site 390333003628 metal binding site 2 [ion binding]; metal-binding site 390333003629 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 390333003630 putative DNA binding site [nucleotide binding]; other site 390333003631 putative metal binding site [ion binding]; other site 390333003632 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 390333003633 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 390333003634 active site 390333003635 DNA binding site [nucleotide binding] 390333003636 catalytic site [active] 390333003637 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 390333003638 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 390333003639 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 390333003640 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 390333003641 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 390333003642 putative tRNA-binding site [nucleotide binding]; other site 390333003643 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 390333003644 catalytic residues [active] 390333003645 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 390333003646 S-adenosylmethionine binding site [chemical binding]; other site 390333003647 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 390333003648 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 390333003649 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 390333003650 Walker A/P-loop; other site 390333003651 ATP binding site [chemical binding]; other site 390333003652 Q-loop/lid; other site 390333003653 ABC transporter signature motif; other site 390333003654 Walker B; other site 390333003655 D-loop; other site 390333003656 H-loop/switch region; other site 390333003657 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 390333003658 HIT family signature motif; other site 390333003659 catalytic residue [active] 390333003660 YtxH-like protein; Region: YtxH; pfam12732 390333003661 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 390333003662 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 390333003663 heterodimer interface [polypeptide binding]; other site 390333003664 active site 390333003665 FMN binding site [chemical binding]; other site 390333003666 homodimer interface [polypeptide binding]; other site 390333003667 substrate binding site [chemical binding]; other site 390333003668 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 390333003669 active site 390333003670 dimer interface [polypeptide binding]; other site 390333003671 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 390333003672 active site 390333003673 peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405 390333003674 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 390333003675 P-loop containing region of AAA domain; Region: AAA_29; cl17516 390333003676 AAA domain; Region: AAA_23; pfam13476 390333003677 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 390333003678 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 390333003679 active site 390333003680 metal binding site [ion binding]; metal-binding site 390333003681 DNA binding site [nucleotide binding] 390333003682 hypothetical protein; Provisional; Region: PRK13676 390333003683 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 390333003684 Transglycosylase; Region: Transgly; pfam00912 390333003685 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 390333003686 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 390333003687 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 390333003688 active site 390333003689 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 390333003690 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 390333003691 intersubunit interface [polypeptide binding]; other site 390333003692 active site 390333003693 zinc binding site [ion binding]; other site 390333003694 Na+ binding site [ion binding]; other site 390333003695 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098 390333003696 catalytic site [active] 390333003697 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098 390333003698 active site 390333003699 Rib/alpha-like repeat; Region: Rib; pfam08428 390333003700 Rib/alpha-like repeat; Region: Rib; cl07159 390333003701 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 390333003702 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 390333003703 putative substrate binding site [chemical binding]; other site 390333003704 putative ATP binding site [chemical binding]; other site 390333003705 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 390333003706 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 390333003707 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 390333003708 stage V sporulation protein B; Region: spore_V_B; TIGR02900 390333003709 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 390333003710 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 390333003711 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 390333003712 HIGH motif; other site 390333003713 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 390333003714 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 390333003715 active site 390333003716 KMSKS motif; other site 390333003717 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 390333003718 tRNA binding surface [nucleotide binding]; other site 390333003719 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 390333003720 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 390333003721 active site 390333003722 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 390333003723 Major Facilitator Superfamily; Region: MFS_1; pfam07690 390333003724 putative substrate translocation pore; other site 390333003725 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 390333003726 S-adenosylmethionine synthetase; Validated; Region: PRK05250 390333003727 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 390333003728 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 390333003729 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 390333003730 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 390333003731 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 390333003732 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 390333003733 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 390333003734 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 390333003735 Protein of unknown function (DUF1461); Region: DUF1461; pfam07314 390333003736 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 390333003737 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 390333003738 active site 390333003739 motif I; other site 390333003740 motif II; other site 390333003741 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 390333003742 Protein of unknown function (DUF1027); Region: DUF1027; pfam06265 390333003743 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 390333003744 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 390333003745 active site 390333003746 metal binding site [ion binding]; metal-binding site 390333003747 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 390333003748 catabolite control protein A; Region: ccpA; TIGR01481 390333003749 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 390333003750 DNA binding site [nucleotide binding] 390333003751 domain linker motif; other site 390333003752 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 390333003753 dimerization interface [polypeptide binding]; other site 390333003754 effector binding site; other site 390333003755 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 390333003756 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 390333003757 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 390333003758 active site 390333003759 Bacterial protein of unknown function (DUF948); Region: DUF948; pfam06103 390333003760 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 390333003761 Mechanosensitive ion channel; Region: MS_channel; pfam00924 390333003762 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 390333003763 active site 390333003764 dimerization interface [polypeptide binding]; other site 390333003765 Protein of unknown function (DUF2507); Region: DUF2507; pfam10702 390333003766 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 390333003767 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 390333003768 catalytic residues [active] 390333003769 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 390333003770 MutS domain III; Region: MutS_III; pfam05192 390333003771 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 390333003772 Walker A/P-loop; other site 390333003773 ATP binding site [chemical binding]; other site 390333003774 Q-loop/lid; other site 390333003775 ABC transporter signature motif; other site 390333003776 Walker B; other site 390333003777 D-loop; other site 390333003778 H-loop/switch region; other site 390333003779 Smr domain; Region: Smr; pfam01713 390333003780 hypothetical protein; Provisional; Region: PRK13678 390333003781 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 390333003782 hypothetical protein; Provisional; Region: PRK05473 390333003783 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 390333003784 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 390333003785 motif 1; other site 390333003786 active site 390333003787 motif 2; other site 390333003788 motif 3; other site 390333003789 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 390333003790 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 390333003791 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 390333003792 ATP binding site [chemical binding]; other site 390333003793 putative Mg++ binding site [ion binding]; other site 390333003794 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 390333003795 nucleotide binding region [chemical binding]; other site 390333003796 ATP-binding site [chemical binding]; other site 390333003797 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 390333003798 DHH family; Region: DHH; pfam01368 390333003799 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 390333003800 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 390333003801 active site 390333003802 DNA polymerase IV; Validated; Region: PRK02406 390333003803 DNA binding site [nucleotide binding] 390333003804 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 390333003805 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 390333003806 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 390333003807 Preprotein translocase subunit; Region: YajC; pfam02699 390333003808 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 390333003809 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 390333003810 Walker A motif; other site 390333003811 ATP binding site [chemical binding]; other site 390333003812 Walker B motif; other site 390333003813 arginine finger; other site 390333003814 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 390333003815 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 390333003816 RuvA N terminal domain; Region: RuvA_N; pfam01330 390333003817 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 390333003818 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 390333003819 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 390333003820 ATP binding site [chemical binding]; other site 390333003821 Mg2+ binding site [ion binding]; other site 390333003822 G-X-G motif; other site 390333003823 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 390333003824 ATP binding site [chemical binding]; other site 390333003825 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 390333003826 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 390333003827 MutS domain I; Region: MutS_I; pfam01624 390333003828 MutS domain II; Region: MutS_II; pfam05188 390333003829 MutS domain III; Region: MutS_III; pfam05192 390333003830 MutS domain V; Region: MutS_V; pfam00488 390333003831 Walker A/P-loop; other site 390333003832 ATP binding site [chemical binding]; other site 390333003833 Q-loop/lid; other site 390333003834 ABC transporter signature motif; other site 390333003835 Walker B; other site 390333003836 D-loop; other site 390333003837 H-loop/switch region; other site 390333003838 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 390333003839 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 390333003840 ring oligomerisation interface [polypeptide binding]; other site 390333003841 ATP/Mg binding site [chemical binding]; other site 390333003842 stacking interactions; other site 390333003843 hinge regions; other site 390333003844 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 390333003845 oligomerisation interface [polypeptide binding]; other site 390333003846 mobile loop; other site 390333003847 roof hairpin; other site 390333003848 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 390333003849 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 390333003850 CoA binding domain; Region: CoA_binding; pfam02629 390333003851 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 390333003852 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 390333003853 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 390333003854 ABC transporter; Region: ABC_tran_2; pfam12848 390333003855 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 390333003856 UGMP family protein; Validated; Region: PRK09604 390333003857 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 390333003858 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 390333003859 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 390333003860 Coenzyme A binding pocket [chemical binding]; other site 390333003861 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 390333003862 Glycoprotease family; Region: Peptidase_M22; pfam00814 390333003863 Acyl-ACP thioesterase; Region: Acyl-ACP_TE; pfam01643 390333003864 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 390333003865 active site 390333003866 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 390333003867 active site 390333003868 Predicted methyltransferases [General function prediction only]; Region: COG0313 390333003869 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 390333003870 putative SAM binding site [chemical binding]; other site 390333003871 putative homodimer interface [polypeptide binding]; other site 390333003872 DNA replication intiation control protein YabA; Reviewed; Region: PRK13169 390333003873 DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177 390333003874 Protein of unknown function (DUF970); Region: DUF970; cl17525 390333003875 thymidylate kinase; Validated; Region: tmk; PRK00698 390333003876 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 390333003877 TMP-binding site; other site 390333003878 ATP-binding site [chemical binding]; other site 390333003879 Protein of unknown function (DUF2508); Region: DUF2508; pfam10704 390333003880 recombination protein RecR; Reviewed; Region: recR; PRK00076 390333003881 RecR protein; Region: RecR; pfam02132 390333003882 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 390333003883 putative active site [active] 390333003884 putative metal-binding site [ion binding]; other site 390333003885 tetramer interface [polypeptide binding]; other site 390333003886 hypothetical protein; Validated; Region: PRK00153 390333003887 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 390333003888 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 390333003889 Walker A motif; other site 390333003890 ATP binding site [chemical binding]; other site 390333003891 Walker B motif; other site 390333003892 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 390333003893 nucleoside/Zn binding site; other site 390333003894 dimer interface [polypeptide binding]; other site 390333003895 catalytic motif [active] 390333003896 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 390333003897 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 390333003898 S-adenosylmethionine binding site [chemical binding]; other site 390333003899 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 390333003900 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 390333003901 active site 390333003902 Beta-lactamase; Region: Beta-lactamase; pfam00144 390333003903 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 390333003904 Beta-lactamase; Region: Beta-lactamase; pfam00144 390333003905 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 390333003906 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 390333003907 IHF dimer interface [polypeptide binding]; other site 390333003908 IHF - DNA interface [nucleotide binding]; other site 390333003909 ApbE family; Region: ApbE; pfam02424 390333003910 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 390333003911 beta-alpha-beta structure motif; other site 390333003912 NAD binding pocket [chemical binding]; other site 390333003913 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 390333003914 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 390333003915 core dimer interface [polypeptide binding]; other site 390333003916 peripheral dimer interface [polypeptide binding]; other site 390333003917 L10 interface [polypeptide binding]; other site 390333003918 L11 interface [polypeptide binding]; other site 390333003919 putative EF-Tu interaction site [polypeptide binding]; other site 390333003920 putative EF-G interaction site [polypeptide binding]; other site 390333003921 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 390333003922 23S rRNA interface [nucleotide binding]; other site 390333003923 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 390333003924 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 390333003925 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 390333003926 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 390333003927 active site 390333003928 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 390333003929 mRNA/rRNA interface [nucleotide binding]; other site 390333003930 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 390333003931 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 390333003932 23S rRNA interface [nucleotide binding]; other site 390333003933 L7/L12 interface [polypeptide binding]; other site 390333003934 putative thiostrepton binding site; other site 390333003935 L25 interface [polypeptide binding]; other site 390333003936 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 390333003937 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 390333003938 putative homodimer interface [polypeptide binding]; other site 390333003939 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 390333003940 heterodimer interface [polypeptide binding]; other site 390333003941 homodimer interface [polypeptide binding]; other site 390333003942 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 390333003943 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 390333003944 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 390333003945 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 390333003946 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 390333003947 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 390333003948 Ribonuclease III family protein [Replication, recombination, and repair]; Region: COG1939 390333003949 active site 390333003950 metal binding site [ion binding]; metal-binding site 390333003951 dimerization interface [polypeptide binding]; other site 390333003952 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 390333003953 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 390333003954 active site 390333003955 HIGH motif; other site 390333003956 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 390333003957 KMSKS motif; other site 390333003958 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 390333003959 tRNA binding surface [nucleotide binding]; other site 390333003960 anticodon binding site; other site 390333003961 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674 390333003962 nudix motif; other site 390333003963 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 390333003964 Transcriptional regulator [Transcription]; Region: LysR; COG0583 390333003965 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 390333003966 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 390333003967 dimerization interface [polypeptide binding]; other site 390333003968 Predicted membrane protein [Function unknown]; Region: COG2855 390333003969 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 390333003970 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 390333003971 HIGH motif; other site 390333003972 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 390333003973 active site 390333003974 KMSKS motif; other site 390333003975 Predicted transcriptional regulators [Transcription]; Region: COG1725 390333003976 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 390333003977 DNA-binding site [nucleotide binding]; DNA binding site 390333003978 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 390333003979 ADP-ribose binding site [chemical binding]; other site 390333003980 dimer interface [polypeptide binding]; other site 390333003981 active site 390333003982 nudix motif; other site 390333003983 metal binding site [ion binding]; metal-binding site 390333003984 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 390333003985 glucose-1-phosphate thymidylyltransferase RfbA; Provisional; Region: PRK15480 390333003986 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 390333003987 active site 390333003988 Substrate binding site; other site 390333003989 Mg++ binding site; other site 390333003990 H+ Antiporter protein; Region: 2A0121; TIGR00900 390333003991 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 390333003992 putative substrate translocation pore; other site 390333003993 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 390333003994 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 390333003995 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 390333003996 active site 390333003997 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 390333003998 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; pfam07155 390333003999 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 390333004000 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 390333004001 putative catalytic cysteine [active] 390333004002 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 390333004003 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 390333004004 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 390333004005 Walker A/P-loop; other site 390333004006 ATP binding site [chemical binding]; other site 390333004007 Q-loop/lid; other site 390333004008 ABC transporter signature motif; other site 390333004009 Walker B; other site 390333004010 D-loop; other site 390333004011 H-loop/switch region; other site 390333004012 ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558 390333004013 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 390333004014 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 390333004015 Walker A/P-loop; other site 390333004016 ATP binding site [chemical binding]; other site 390333004017 Q-loop/lid; other site 390333004018 ABC transporter signature motif; other site 390333004019 Walker B; other site 390333004020 D-loop; other site 390333004021 H-loop/switch region; other site 390333004022 hypothetical protein; Provisional; Region: PRK13661 390333004023 Uncharacterized conserved protein [Function unknown]; Region: COG1912 390333004024 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 390333004025 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 390333004026 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 390333004027 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 390333004028 Walker A/P-loop; other site 390333004029 ATP binding site [chemical binding]; other site 390333004030 Q-loop/lid; other site 390333004031 ABC transporter signature motif; other site 390333004032 Walker B; other site 390333004033 D-loop; other site 390333004034 H-loop/switch region; other site 390333004035 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 390333004036 DNA-binding site [nucleotide binding]; DNA binding site 390333004037 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 390333004038 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 390333004039 Ligand binding site; other site 390333004040 metal-binding site 390333004041 DNA repair protein RadA; Provisional; Region: PRK11823 390333004042 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 390333004043 Walker A motif/ATP binding site; other site 390333004044 ATP binding site [chemical binding]; other site 390333004045 Walker B motif; other site 390333004046 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 390333004047 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 390333004048 trimer interface [polypeptide binding]; other site 390333004049 active site 390333004050 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 390333004051 trimer interface [polypeptide binding]; other site 390333004052 active site 390333004053 G bulge; other site 390333004054 AAA domain; Region: AAA_33; pfam13671 390333004055 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 390333004056 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 390333004057 catalytic core [active] 390333004058 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 390333004059 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 390333004060 catalytic core [active] 390333004061 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 390333004062 DJ-1 family protein; Region: not_thiJ; TIGR01383 390333004063 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 390333004064 conserved cys residue [active] 390333004065 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 390333004066 Coenzyme A binding pocket [chemical binding]; other site 390333004067 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 390333004068 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 390333004069 active site 390333004070 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 390333004071 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 390333004072 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 390333004073 dipeptidase PepV; Region: dipeptidase; TIGR01886 390333004074 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 390333004075 active site 390333004076 metal binding site [ion binding]; metal-binding site 390333004077 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 390333004078 Aspartase; Region: Aspartase; cd01357 390333004079 active sites [active] 390333004080 tetramer interface [polypeptide binding]; other site 390333004081 SEC10/PgrA surface exclusion domain; Region: Surf_Exclu_PgrA; TIGR04320 390333004082 Transposase; Region: DEDD_Tnp_IS110; pfam01548 390333004083 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 390333004084 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 390333004085 similar to hypothetical protein; This sequence makes part of ISL4 390333004086 similar to hypothetical protein; This sequence makes part of ISL4 390333004087 homoserine kinase; Provisional; Region: PRK01212 390333004088 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 390333004089 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 390333004090 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 390333004091 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 390333004092 pyridoxal 5'-phosphate binding site [chemical binding]; other site 390333004093 catalytic residue [active] 390333004094 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 390333004095 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 390333004096 Coenzyme A binding pocket [chemical binding]; other site 390333004097 Protein of unknown function (DUF1211); Region: DUF1211; pfam06736 390333004098 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 390333004099 HPr interaction site; other site 390333004100 glycerol kinase (GK) interaction site [polypeptide binding]; other site 390333004101 active site 390333004102 phosphorylation site [posttranslational modification] 390333004103 6-phosphofructokinase; Provisional; Region: PRK03202 390333004104 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 390333004105 active site 390333004106 ADP/pyrophosphate binding site [chemical binding]; other site 390333004107 dimerization interface [polypeptide binding]; other site 390333004108 allosteric effector site; other site 390333004109 fructose-1,6-bisphosphate binding site; other site 390333004110 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 390333004111 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 390333004112 active site 390333004113 substrate binding site [chemical binding]; other site 390333004114 metal binding site [ion binding]; metal-binding site 390333004115 putative ornithine decarboxylase; Region: lacto_ODC_hypo; TIGR04318 390333004116 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 390333004117 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 390333004118 catalytic residue [active] 390333004119 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 390333004120 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 390333004121 Major Facilitator Superfamily; Region: MFS_1; pfam07690 390333004122 putative substrate translocation pore; other site 390333004123 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 390333004124 putative substrate translocation pore; other site 390333004125 Major Facilitator Superfamily; Region: MFS_1; pfam07690 390333004126 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 390333004127 Helix-turn-helix domain; Region: HTH_38; pfam13936 390333004128 Integrase core domain; Region: rve; pfam00665 390333004129 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 390333004130 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 390333004131 putative substrate translocation pore; other site 390333004132 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b1; cd09203 390333004133 PLD-like domain; Region: PLDc_2; pfam13091 390333004134 putative homodimer interface [polypeptide binding]; other site 390333004135 putative active site [active] 390333004136 catalytic site [active] 390333004137 DEAD-like helicases superfamily; Region: DEXDc; smart00487 390333004138 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 390333004139 ATP binding site [chemical binding]; other site 390333004140 putative Mg++ binding site [ion binding]; other site 390333004141 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 390333004142 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 390333004143 nucleotide binding region [chemical binding]; other site 390333004144 ATP-binding site [chemical binding]; other site 390333004145 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 390333004146 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 390333004147 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 390333004148 NAD binding site [chemical binding]; other site 390333004149 homodimer interface [polypeptide binding]; other site 390333004150 active site 390333004151 substrate binding site [chemical binding]; other site 390333004152 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 390333004153 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 390333004154 non-specific DNA binding site [nucleotide binding]; other site 390333004155 salt bridge; other site 390333004156 sequence-specific DNA binding site [nucleotide binding]; other site 390333004157 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 390333004158 NlpC/P60 family; Region: NLPC_P60; pfam00877 390333004159 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 390333004160 Spore germination protein; Region: Spore_permease; cl17796 390333004161 replication factor C small subunit 2; Reviewed; Region: PRK12402 390333004162 Domain of unknown function (DUF956); Region: DUF956; pfam06115 390333004163 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 390333004164 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 390333004165 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 390333004166 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 390333004167 active pocket/dimerization site; other site 390333004168 active site 390333004169 phosphorylation site [posttranslational modification] 390333004170 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 390333004171 active site 390333004172 phosphorylation site [posttranslational modification] 390333004173 Transposase; Region: DEDD_Tnp_IS110; pfam01548 390333004174 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 390333004175 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 390333004176 similar to hypothetical protein; This sequence makes part of ISL4 390333004177 similar to hypothetical protein; This sequence makes part of ISL4 390333004178 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 390333004179 H+/citrate symporter [Energy production and conversion]; Region: CitM; cl17620 390333004180 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 390333004181 FeS assembly protein SufB; Region: sufB; TIGR01980 390333004182 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 390333004183 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 390333004184 trimerization site [polypeptide binding]; other site 390333004185 active site 390333004186 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 390333004187 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 390333004188 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 390333004189 catalytic residue [active] 390333004190 FeS assembly protein SufD; Region: sufD; TIGR01981 390333004191 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 390333004192 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 390333004193 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 390333004194 Walker A/P-loop; other site 390333004195 ATP binding site [chemical binding]; other site 390333004196 Q-loop/lid; other site 390333004197 ABC transporter signature motif; other site 390333004198 Walker B; other site 390333004199 D-loop; other site 390333004200 H-loop/switch region; other site 390333004201 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 390333004202 Coenzyme A binding pocket [chemical binding]; other site 390333004203 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 390333004204 HPr interaction site; other site 390333004205 glycerol kinase (GK) interaction site [polypeptide binding]; other site 390333004206 active site 390333004207 phosphorylation site [posttranslational modification] 390333004208 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 390333004209 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 390333004210 Walker A/P-loop; other site 390333004211 ATP binding site [chemical binding]; other site 390333004212 Q-loop/lid; other site 390333004213 ABC transporter signature motif; other site 390333004214 Walker B; other site 390333004215 D-loop; other site 390333004216 H-loop/switch region; other site 390333004217 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 390333004218 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 390333004219 SmpB-tmRNA interface; other site 390333004220 ribonuclease R; Region: RNase_R; TIGR02063 390333004221 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 390333004222 RNB domain; Region: RNB; pfam00773 390333004223 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 390333004224 RNA binding site [nucleotide binding]; other site 390333004225 preprotein translocase subunit SecG; Reviewed; Region: secG; PRK06870 390333004226 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 390333004227 Sulfatase; Region: Sulfatase; pfam00884 390333004228 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 390333004229 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 390333004230 Glycosyl transferase 4-like domain; Region: Glyco_trans_4_4; pfam13579 390333004231 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 390333004232 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 390333004233 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 390333004234 putative ADP-binding pocket [chemical binding]; other site 390333004235 similar to hypothetical protein; This sequence makes part of ISL4 390333004236 similar to hypothetical protein; This sequence makes part of ISL4 390333004237 Transposase; Region: DEDD_Tnp_IS110; pfam01548 390333004238 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 390333004239 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 390333004240 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 390333004241 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 390333004242 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 390333004243 seryl-tRNA synthetase; Provisional; Region: PRK05431 390333004244 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 390333004245 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 390333004246 dimer interface [polypeptide binding]; other site 390333004247 active site 390333004248 motif 1; other site 390333004249 motif 2; other site 390333004250 motif 3; other site 390333004251 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 390333004252 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 390333004253 Uncharacterized conserved protein [Function unknown]; Region: COG0398 390333004254 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 390333004255 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 390333004256 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 390333004257 non-specific DNA binding site [nucleotide binding]; other site 390333004258 salt bridge; other site 390333004259 sequence-specific DNA binding site [nucleotide binding]; other site 390333004260 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014 390333004261 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 390333004262 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 390333004263 catalytic triad [active] 390333004264 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 390333004265 MMPL family; Region: MMPL; pfam03176 390333004266 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 390333004267 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 390333004268 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 390333004269 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 390333004270 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 390333004271 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 390333004272 Cl binding site [ion binding]; other site 390333004273 oligomer interface [polypeptide binding]; other site 390333004274 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 390333004275 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 390333004276 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 390333004277 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; cl17626 390333004278 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 390333004279 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 390333004280 active site 390333004281 catalytic tetrad [active] 390333004282 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 390333004283 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 390333004284 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 390333004285 Walker A/P-loop; other site 390333004286 ATP binding site [chemical binding]; other site 390333004287 Q-loop/lid; other site 390333004288 ABC transporter signature motif; other site 390333004289 Walker B; other site 390333004290 D-loop; other site 390333004291 H-loop/switch region; other site 390333004292 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 390333004293 Helix-turn-helix domain; Region: HTH_38; pfam13936 390333004294 Integrase core domain; Region: rve; pfam00665 390333004295 aldehyde dehydrogenase family 7 member; Region: PLN02315 390333004296 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 390333004297 TAP-like protein; Region: Abhydrolase_4; pfam08386 390333004298 Helix-turn-helix domain; Region: HTH_25; pfam13413 390333004299 elongation factor P; Validated; Region: PRK00529 390333004300 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 390333004301 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 390333004302 RNA binding site [nucleotide binding]; other site 390333004303 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 390333004304 RNA binding site [nucleotide binding]; other site 390333004305 pantothenate kinase; Provisional; Region: PRK05439 390333004306 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 390333004307 ATP-binding site [chemical binding]; other site 390333004308 CoA-binding site [chemical binding]; other site 390333004309 Mg2+-binding site [ion binding]; other site 390333004310 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 390333004311 active site 390333004312 catalytic triad [active] 390333004313 oxyanion hole [active] 390333004314 LytTr DNA-binding domain; Region: LytTR; smart00850 390333004315 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 390333004316 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 390333004317 Part of AAA domain; Region: AAA_19; pfam13245 390333004318 Family description; Region: UvrD_C_2; pfam13538 390333004319 Zinc-dependent metalloprotease, MMP_like subfamily. This group contains matrix metalloproteinases (MMPs), serralysins, and the astacin_like family of proteases; Region: ZnMc_MMP_like; cd04268 390333004320 active site 390333004321 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 390333004322 catalytic core [active] 390333004323 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 390333004324 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 390333004325 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 390333004326 active site 390333004327 catalytic site [active] 390333004328 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 390333004329 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_2; cd08582 390333004330 putative active site [active] 390333004331 catalytic site [active] 390333004332 putative metal binding site [ion binding]; other site 390333004333 VanZ like family; Region: VanZ; pfam04892 390333004334 Predicted membrane protein [Function unknown]; Region: COG2246 390333004335 GtrA-like protein; Region: GtrA; pfam04138 390333004336 Transposase; Region: DEDD_Tnp_IS110; pfam01548 390333004337 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 390333004338 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 390333004339 similar to hypothetical protein; This sequence makes part of ISL4 390333004340 similar to hypothetical protein; This sequence makes part of ISL4 390333004341 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 390333004342 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 390333004343 active site 390333004344 nucleotide binding site [chemical binding]; other site 390333004345 HIGH motif; other site 390333004346 KMSKS motif; other site 390333004347 LicD family; Region: LicD; pfam04991 390333004348 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 390333004349 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 390333004350 Domain of unknown function (DUF4422); Region: DUF4422; pfam14393 390333004351 This family is most closely related to the GT1 family of glycosyltransferases. capH in Staphylococcus aureus has been shown to be required for the biosynthesis of the type 1 capsular polysaccharide (CP1); Region: GT1_CapH_like; cd03812 390333004352 putative ADP-binding pocket [chemical binding]; other site 390333004353 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 390333004354 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 390333004355 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_b; cd04185 390333004356 Probable Catalytic site; other site 390333004357 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 390333004358 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 390333004359 UDP-galactopyranose mutase; Region: GLF; pfam03275 390333004360 Domain of unknown function (DUF4422); Region: DUF4422; pfam14393 390333004361 Bacterial sugar transferase; Region: Bac_transf; pfam02397 390333004362 Core-2/I-Branching enzyme; Region: Branch; pfam02485 390333004363 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 390333004364 SH3 domain protein; Region: SH3_and_anchor; TIGR04211 390333004365 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 390333004366 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 390333004367 non-specific DNA binding site [nucleotide binding]; other site 390333004368 salt bridge; other site 390333004369 sequence-specific DNA binding site [nucleotide binding]; other site 390333004370 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 390333004371 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 390333004372 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 390333004373 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 390333004374 zinc binding site [ion binding]; other site 390333004375 putative ligand binding site [chemical binding]; other site 390333004376 methionine sulfoxide reductase B; Provisional; Region: PRK00222 390333004377 SelR domain; Region: SelR; pfam01641 390333004378 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 390333004379 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 390333004380 NADP binding site [chemical binding]; other site 390333004381 active site 390333004382 putative substrate binding site [chemical binding]; other site 390333004383 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; pfam13930 390333004384 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 390333004385 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 390333004386 Transposase; Region: DEDD_Tnp_IS110; pfam01548 390333004387 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 390333004388 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 390333004389 similar to hypothetical protein; This sequence makes part of ISL4 390333004390 similar to hypothetical protein; This sequence makes part of ISL4 390333004391 Transcriptional regulator [Transcription]; Region: LysR; COG0583 390333004392 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 390333004393 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 390333004394 dimerization interface [polypeptide binding]; other site 390333004395 Transposase [DNA replication, recombination, and repair]; Region: COG5421 390333004396 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 390333004397 This family is most closely related to the GT1 family of glycosyltransferases. capH in Staphylococcus aureus has been shown to be required for the biosynthesis of the type 1 capsular polysaccharide (CP1); Region: GT1_CapH_like; cd03812 390333004398 putative ADP-binding pocket [chemical binding]; other site 390333004399 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 390333004400 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 390333004401 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 390333004402 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 390333004403 UDP-galactopyranose mutase; Region: GLF; pfam03275 390333004404 Domain of unknown function (DUF4422); Region: DUF4422; pfam14393 390333004405 Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; pfam04101 390333004406 Oligosaccharide biosynthesis protein Alg14 like; Region: Alg14; pfam08660 390333004407 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 390333004408 Bacterial sugar transferase; Region: Bac_transf; pfam02397 390333004409 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 390333004410 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 390333004411 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 390333004412 Nucleotide binding site [chemical binding]; other site 390333004413 DTAP/Switch II; other site 390333004414 Switch I; other site 390333004415 Chain length determinant protein; Region: Wzz; cl15801 390333004416 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 390333004417 Chain length determinant protein; Region: Wzz; cl15801 390333004418 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816 390333004419 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 390333004420 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 390333004421 HflX GTPase family; Region: HflX; cd01878 390333004422 G1 box; other site 390333004423 GTP/Mg2+ binding site [chemical binding]; other site 390333004424 Switch I region; other site 390333004425 G2 box; other site 390333004426 G3 box; other site 390333004427 Switch II region; other site 390333004428 G4 box; other site 390333004429 G5 box; other site 390333004430 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 390333004431 NlpC/P60 family; Region: NLPC_P60; cl17555 390333004432 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 390333004433 NlpC/P60 family; Region: NLPC_P60; pfam00877 390333004434 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 390333004435 NlpC/P60 family; Region: NLPC_P60; pfam00877 390333004436 (R)-2-Hydroxyglutarate Dehydrogenase and related dehydrogenases, NAD-binding and catalytic domains; Region: HGDH_like; cd12184 390333004437 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 390333004438 putative homodimer interface [polypeptide binding]; other site 390333004439 putative ligand binding site [chemical binding]; other site 390333004440 putative NAD binding site [chemical binding]; other site 390333004441 catalytic site [active] 390333004442 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 390333004443 NlpC/P60 family; Region: NLPC_P60; pfam00877 390333004444 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 390333004445 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 390333004446 catalytic site [active] 390333004447 G-X2-G-X-G-K; other site 390333004448 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 390333004449 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 390333004450 Uncharacterized conserved protein [Function unknown]; Region: COG2966 390333004451 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 390333004452 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 390333004453 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 390333004454 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 390333004455 Walker A/P-loop; other site 390333004456 ATP binding site [chemical binding]; other site 390333004457 Q-loop/lid; other site 390333004458 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 390333004459 ABC transporter signature motif; other site 390333004460 Walker B; other site 390333004461 D-loop; other site 390333004462 ABC transporter; Region: ABC_tran_2; pfam12848 390333004463 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 390333004464 Predicted membrane protein (DUF2109); Region: DUF2109; cl01660 390333004465 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 390333004466 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 390333004467 Probable transposase; Region: OrfB_IS605; pfam01385 390333004468 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 390333004469 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 390333004470 Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164 390333004471 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 390333004472 active site 390333004473 Zn binding site [ion binding]; other site 390333004474 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 390333004475 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 390333004476 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 390333004477 ABC-ATPase subunit interface; other site 390333004478 dimer interface [polypeptide binding]; other site 390333004479 putative PBP binding regions; other site 390333004480 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 390333004481 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 390333004482 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 390333004483 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 390333004484 active site 390333004485 motif I; other site 390333004486 motif II; other site 390333004487 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 390333004488 motif II; other site 390333004489 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 390333004490 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 390333004491 active site 390333004492 phosphorylation site [posttranslational modification] 390333004493 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 390333004494 active site 390333004495 P-loop; other site 390333004496 phosphorylation site [posttranslational modification] 390333004497 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 390333004498 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 390333004499 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 390333004500 putative substrate binding site [chemical binding]; other site 390333004501 putative ATP binding site [chemical binding]; other site 390333004502 DNA-binding transcriptional activator FucR; Provisional; Region: PRK10411 390333004503 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 390333004504 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 390333004505 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 390333004506 aspartate racemase; Region: asp_race; TIGR00035 390333004507 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 390333004508 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 390333004509 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 390333004510 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 390333004511 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 390333004512 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 390333004513 dimer interface [polypeptide binding]; other site 390333004514 phosphorylation site [posttranslational modification] 390333004515 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 390333004516 ATP binding site [chemical binding]; other site 390333004517 Mg2+ binding site [ion binding]; other site 390333004518 G-X-G motif; other site 390333004519 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 390333004520 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 390333004521 active site 390333004522 phosphorylation site [posttranslational modification] 390333004523 intermolecular recognition site; other site 390333004524 dimerization interface [polypeptide binding]; other site 390333004525 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 390333004526 DNA binding site [nucleotide binding] 390333004527 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 390333004528 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 390333004529 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 390333004530 Walker A/P-loop; other site 390333004531 ATP binding site [chemical binding]; other site 390333004532 Q-loop/lid; other site 390333004533 ABC transporter signature motif; other site 390333004534 Walker B; other site 390333004535 D-loop; other site 390333004536 H-loop/switch region; other site 390333004537 Protein of unknown function (DUF1129); Region: DUF1129; pfam06570 390333004538 GTP-binding protein YchF; Reviewed; Region: PRK09601 390333004539 YchF GTPase; Region: YchF; cd01900 390333004540 G1 box; other site 390333004541 GTP/Mg2+ binding site [chemical binding]; other site 390333004542 Switch I region; other site 390333004543 G2 box; other site 390333004544 Switch II region; other site 390333004545 G3 box; other site 390333004546 G4 box; other site 390333004547 G5 box; other site 390333004548 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 390333004549 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 390333004550 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 390333004551 ParB-like nuclease domain; Region: ParB; smart00470 390333004552 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 390333004553 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 390333004554 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 390333004555 P-loop; other site 390333004556 Magnesium ion binding site [ion binding]; other site 390333004557 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 390333004558 ParB-like nuclease domain; Region: ParB; smart00470 390333004559 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 390333004560 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 390333004561 S-adenosylmethionine binding site [chemical binding]; other site 390333004562 Colicin V production protein; Region: Colicin_V; pfam02674 390333004563 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 390333004564 ApbE family; Region: ApbE; pfam02424 390333004565 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 390333004566 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 390333004567 Predicted flavoprotein [General function prediction only]; Region: COG0431 390333004568 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 390333004569 Predicted flavoprotein [General function prediction only]; Region: COG0431 390333004570 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 390333004571 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 390333004572 WHG domain; Region: WHG; pfam13305 390333004573 Peptidase family C69; Region: Peptidase_C69; pfam03577 390333004574 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 390333004575 HPr interaction site; other site 390333004576 glycerol kinase (GK) interaction site [polypeptide binding]; other site 390333004577 active site 390333004578 phosphorylation site [posttranslational modification] 390333004579 LytTr DNA-binding domain; Region: LytTR; cl04498 390333004580 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 390333004581 Predicted transcriptional regulator [Transcription]; Region: COG2378 390333004582 HTH domain; Region: HTH_11; cl17392 390333004583 WYL domain; Region: WYL; pfam13280 390333004584 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 390333004585 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 390333004586 Walker A/P-loop; other site 390333004587 ATP binding site [chemical binding]; other site 390333004588 Q-loop/lid; other site 390333004589 ABC transporter signature motif; other site 390333004590 Walker B; other site 390333004591 D-loop; other site 390333004592 H-loop/switch region; other site 390333004593 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 390333004594 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 390333004595 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 390333004596 hypothetical protein; Validated; Region: PRK02101 390333004597 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 390333004598 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 390333004599 Peptidase family M1; Region: Peptidase_M1; pfam01433 390333004600 Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601 390333004601 Zn binding site [ion binding]; other site 390333004602 Domain of unknown function (DUF3358); Region: DUF3358; pfam11838 390333004603 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 390333004604 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 390333004605 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 390333004606 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 390333004607 transmembrane helices; other site 390333004608 fumarate hydratase; Reviewed; Region: fumC; PRK00485 390333004609 Class II fumarases; Region: Fumarase_classII; cd01362 390333004610 active site 390333004611 tetramer interface [polypeptide binding]; other site 390333004612 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 390333004613 putative ADP-ribose binding site [chemical binding]; other site 390333004614 putative active site [active] 390333004615 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 390333004616 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 390333004617 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 390333004618 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 390333004619 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 390333004620 Walker A/P-loop; other site 390333004621 ATP binding site [chemical binding]; other site 390333004622 Q-loop/lid; other site 390333004623 ABC transporter signature motif; other site 390333004624 Walker B; other site 390333004625 D-loop; other site 390333004626 H-loop/switch region; other site 390333004627 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 390333004628 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 390333004629 active site 390333004630 substrate binding site [chemical binding]; other site 390333004631 ATP binding site [chemical binding]; other site 390333004632 activation loop (A-loop); other site 390333004633 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 390333004634 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 390333004635 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 390333004636 catalytic triad [active] 390333004637 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 390333004638 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 390333004639 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 390333004640 Walker A motif; other site 390333004641 ATP binding site [chemical binding]; other site 390333004642 Walker B motif; other site 390333004643 arginine finger; other site 390333004644 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 390333004645 Walker A motif; other site 390333004646 ATP binding site [chemical binding]; other site 390333004647 Walker B motif; other site 390333004648 arginine finger; other site 390333004649 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 390333004650 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 390333004651 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 390333004652 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 390333004653 catalytic site [active] 390333004654 subunit interface [polypeptide binding]; other site 390333004655 dihydroorotase; Validated; Region: pyrC; PRK09357 390333004656 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 390333004657 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 390333004658 active site 390333004659 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 390333004660 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 390333004661 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 390333004662 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 390333004663 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 390333004664 active site 390333004665 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 390333004666 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 390333004667 heterodimer interface [polypeptide binding]; other site 390333004668 active site 390333004669 FMN binding site [chemical binding]; other site 390333004670 homodimer interface [polypeptide binding]; other site 390333004671 substrate binding site [chemical binding]; other site 390333004672 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 390333004673 DNA-binding site [nucleotide binding]; DNA binding site 390333004674 RNA-binding motif; other site 390333004675 EamA-like transporter family; Region: EamA; pfam00892 390333004676 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 390333004677 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 390333004678 catalytic triad [active] 390333004679 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 390333004680 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 390333004681 active site 390333004682 motif I; other site 390333004683 motif II; other site 390333004684 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 390333004685 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 390333004686 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 390333004687 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 390333004688 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 390333004689 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 390333004690 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 390333004691 Walker A/P-loop; other site 390333004692 ATP binding site [chemical binding]; other site 390333004693 Q-loop/lid; other site 390333004694 ABC transporter signature motif; other site 390333004695 Walker B; other site 390333004696 D-loop; other site 390333004697 H-loop/switch region; other site 390333004698 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 390333004699 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 390333004700 FtsX-like permease family; Region: FtsX; pfam02687 390333004701 similar to hypothetical protein 390333004702 D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092 390333004703 DltD N-terminal region; Region: DltD_N; pfam04915 390333004704 DltD central region; Region: DltD_M; pfam04918 390333004705 DltD C-terminal region; Region: DltD_C; pfam04914 390333004706 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 390333004707 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 390333004708 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 390333004709 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 390333004710 acyl-activating enzyme (AAE) consensus motif; other site 390333004711 AMP binding site [chemical binding]; other site 390333004712 Transposase; Region: DEDD_Tnp_IS110; pfam01548 390333004713 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 390333004714 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 390333004715 similar to hypothetical protein; This sequence makes part of ISL4 390333004716 similar to hypothetical protein; This sequence makes part of ISL4 390333004717 FOG: CBS domain [General function prediction only]; Region: COG0517 390333004718 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 390333004719 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 390333004720 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 390333004721 Soluble P-type ATPase [General function prediction only]; Region: COG4087 390333004722 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 390333004723 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 390333004724 CAAX protease self-immunity; Region: Abi; pfam02517 390333004725 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 390333004726 putative active site [active] 390333004727 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 390333004728 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 390333004729 ligand binding site [chemical binding]; other site 390333004730 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 390333004731 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 390333004732 ligand binding site [chemical binding]; other site 390333004733 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 390333004734 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 390333004735 dimer interface [polypeptide binding]; other site 390333004736 conserved gate region; other site 390333004737 putative PBP binding loops; other site 390333004738 ABC-ATPase subunit interface; other site 390333004739 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 390333004740 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 390333004741 dimer interface [polypeptide binding]; other site 390333004742 conserved gate region; other site 390333004743 putative PBP binding loops; other site 390333004744 ABC-ATPase subunit interface; other site 390333004745 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 390333004746 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 390333004747 Walker A/P-loop; other site 390333004748 ATP binding site [chemical binding]; other site 390333004749 Q-loop/lid; other site 390333004750 ABC transporter signature motif; other site 390333004751 Walker B; other site 390333004752 D-loop; other site 390333004753 H-loop/switch region; other site 390333004754 TOBE domain; Region: TOBE_2; pfam08402 390333004755 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 390333004756 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 390333004757 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 390333004758 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 390333004759 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 390333004760 active site 390333004761 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 390333004762 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 390333004763 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 390333004764 ligand binding site [chemical binding]; other site 390333004765 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 390333004766 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 390333004767 Walker A/P-loop; other site 390333004768 ATP binding site [chemical binding]; other site 390333004769 Q-loop/lid; other site 390333004770 ABC transporter signature motif; other site 390333004771 Walker B; other site 390333004772 D-loop; other site 390333004773 H-loop/switch region; other site 390333004774 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 390333004775 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 390333004776 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 390333004777 TM-ABC transporter signature motif; other site 390333004778 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 390333004779 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 390333004780 TM-ABC transporter signature motif; other site 390333004781 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 390333004782 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 390333004783 active site 390333004784 catalytic tetrad [active] 390333004785 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 390333004786 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 390333004787 active site 390333004788 trimer interface [polypeptide binding]; other site 390333004789 allosteric site; other site 390333004790 active site lid [active] 390333004791 hexamer (dimer of trimers) interface [polypeptide binding]; other site 390333004792 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 390333004793 active site 390333004794 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 390333004795 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 390333004796 Substrate-binding site [chemical binding]; other site 390333004797 Substrate specificity [chemical binding]; other site 390333004798 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 390333004799 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 390333004800 Substrate-binding site [chemical binding]; other site 390333004801 Substrate specificity [chemical binding]; other site 390333004802 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 390333004803 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 390333004804 substrate binding pocket [chemical binding]; other site 390333004805 membrane-bound complex binding site; other site 390333004806 hinge residues; other site 390333004807 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 390333004808 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 390333004809 dimer interface [polypeptide binding]; other site 390333004810 conserved gate region; other site 390333004811 putative PBP binding loops; other site 390333004812 ABC-ATPase subunit interface; other site 390333004813 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 390333004814 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 390333004815 Walker A/P-loop; other site 390333004816 ATP binding site [chemical binding]; other site 390333004817 Q-loop/lid; other site 390333004818 ABC transporter signature motif; other site 390333004819 Walker B; other site 390333004820 D-loop; other site 390333004821 H-loop/switch region; other site 390333004822 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 390333004823 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 390333004824 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 390333004825 Cl- selectivity filter; other site 390333004826 Cl- binding residues [ion binding]; other site 390333004827 pore gating glutamate residue; other site 390333004828 dimer interface [polypeptide binding]; other site 390333004829 H+/Cl- coupling transport residue; other site 390333004830 TrkA-C domain; Region: TrkA_C; pfam02080 390333004831 This CD includes bacterial (Agrobacterium tumefaciens and Caulobacter crescentus ProX, and Clostridium sticklandii PrdX) and eukaryotic (Plasmodium falciparum N-terminal ProRS editing domain) sequences. The C. sticklandii PrdX protein, a homolog of the...; Region: PrdX_deacylase; cd04335 390333004832 putative deacylase active site [active] 390333004833 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 390333004834 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 390333004835 Walker A/P-loop; other site 390333004836 ATP binding site [chemical binding]; other site 390333004837 Q-loop/lid; other site 390333004838 ABC transporter signature motif; other site 390333004839 Walker B; other site 390333004840 D-loop; other site 390333004841 H-loop/switch region; other site 390333004842 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 390333004843 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 390333004844 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 390333004845 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 390333004846 pyruvate oxidase; Region: pyruv_oxi_spxB; TIGR02720 390333004847 PYR/PP interface [polypeptide binding]; other site 390333004848 dimer interface [polypeptide binding]; other site 390333004849 TPP binding site [chemical binding]; other site 390333004850 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 390333004851 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 390333004852 TPP-binding site [chemical binding]; other site 390333004853 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 390333004854 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 390333004855 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 390333004856 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 390333004857 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 390333004858 trmE is a tRNA modification GTPase; Region: trmE; cd04164 390333004859 G1 box; other site 390333004860 GTP/Mg2+ binding site [chemical binding]; other site 390333004861 Switch I region; other site 390333004862 G2 box; other site 390333004863 Switch II region; other site 390333004864 G3 box; other site 390333004865 G4 box; other site 390333004866 G5 box; other site 390333004867 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 390333004868 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 390333004869 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 390333004870 ribonuclease P; Reviewed; Region: rnpA; PRK00499 390333004871 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399