-- dump date   	20140619_123043
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
498216000001	Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970
498216000002	RelB antitoxin; Region: RelB; cl01171
498216000003	Zeta toxin; Region: Zeta_toxin; pfam06414
498216000004	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185
498216000005	Protein of unknown function (DUF3847); Region: DUF3847; pfam12958
498216000006	MobA/MobL family; Region: MobA_MobL; pfam03389
498216000007	type IV secretion/conjugal transfer ATPase, VirB4 family; Region: VirB4_CagE; TIGR00929
498216000008	CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135
498216000009	AAA-like domain; Region: AAA_10; pfam12846
498216000010	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
498216000011	G1 box; other site
498216000012	GTP/Mg2+ binding site [chemical binding]; other site
498216000013	Switch I region; other site
498216000014	type VII secretion protein EssB; Region: T7_EssB; TIGR03926
498216000015	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
498216000016	N-acetyl-D-glucosamine binding site [chemical binding]; other site
498216000017	catalytic residue [active]
498216000018	Bacteriophage peptidoglycan hydrolase; Region: Amidase_5; pfam05382
498216000019	Protein of unknown function (DUF3251); Region: DUF3251; cl08186
498216000020	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
498216000021	catalytic residues [active]
498216000022	Type IV secretion-system coupling protein DNA-binding domain; Region: TrwB_AAD_bind; pfam10412
498216000023	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
498216000024	Walker A motif; other site
498216000025	ATP binding site [chemical binding]; other site
498216000026	Walker B motif; other site
498216000027	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
498216000028	DNA topoisomerase III; Provisional; Region: PRK07726
498216000029	active site
498216000030	putative interdomain interaction site [polypeptide binding]; other site
498216000031	putative metal-binding site [ion binding]; other site
498216000032	putative nucleotide binding site [chemical binding]; other site
498216000033	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
498216000034	domain I; other site
498216000035	DNA binding groove [nucleotide binding]
498216000036	phosphate binding site [ion binding]; other site
498216000037	domain II; other site
498216000038	domain III; other site
498216000039	nucleotide binding site [chemical binding]; other site
498216000040	catalytic site [active]
498216000041	domain IV; other site
498216000042	Domain of unknown function (DUF955); Region: DUF955; cl01076
498216000043	pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK07251
498216000044	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
498216000045	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
498216000046	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
498216000047	SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747
498216000048	Nicotinamide mononucleotide transporter; Region: NMN_transporter; cl01256
498216000049	Cna protein B-type domain; Region: Cna_B; pfam05738
498216000050	Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222
498216000051	domain interaction interfaces [polypeptide binding]; other site
498216000052	Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222
498216000053	domain interaction interfaces [polypeptide binding]; other site
498216000054	Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222
498216000055	domain interaction interfaces [polypeptide binding]; other site
498216000056	Predicted transcriptional regulators [Transcription]; Region: COG1733
498216000057	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
498216000058	Arginate lyase and other MDR family members; Region: AL_MDR; cd08252
498216000059	zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817
498216000060	putative NAD(P) binding site [chemical binding]; other site
498216000061	dimer interface [polypeptide binding]; other site
498216000062	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
498216000063	multiple promoter invertase; Provisional; Region: mpi; PRK13413
498216000064	catalytic residues [active]
498216000065	catalytic nucleophile [active]
498216000066	Presynaptic Site I dimer interface [polypeptide binding]; other site
498216000067	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
498216000068	Synaptic Flat tetramer interface [polypeptide binding]; other site
498216000069	Synaptic Site I dimer interface [polypeptide binding]; other site
498216000070	DNA binding site [nucleotide binding]
498216000071	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
498216000072	DNA-binding interface [nucleotide binding]; DNA binding site
498216000073	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041; cl17396
498216000074	RelB antitoxin; Region: RelB; cl01171
498216000075	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
498216000076	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
498216000077	P-loop; other site
498216000078	Magnesium ion binding site [ion binding]; other site
498216000079	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
498216000080	Magnesium ion binding site [ion binding]; other site
498216000081	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
498216000082	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
498216000083	Walker A motif; other site
498216000084	ATP binding site [chemical binding]; other site
498216000085	Walker B motif; other site
498216000086	arginine finger; other site
498216000087	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
498216000088	DnaA box-binding interface [nucleotide binding]; other site
498216000089	DNA polymerase III subunit beta; Validated; Region: PRK05643
498216000090	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
498216000091	putative DNA binding surface [nucleotide binding]; other site
498216000092	dimer interface [polypeptide binding]; other site
498216000093	beta-clamp/clamp loader binding surface; other site
498216000094	beta-clamp/translesion DNA polymerase binding surface; other site
498216000095	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
498216000096	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
498216000097	putative active site [active]
498216000098	putative NTP binding site [chemical binding]; other site
498216000099	putative nucleic acid binding site [nucleotide binding]; other site
498216000100	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
498216000101	S4-like RNA binding protein [Replication, recombination, and repair]; Region: COG2501
498216000102	recombination protein F; Reviewed; Region: recF; PRK00064
498216000103	ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242
498216000104	Walker A/P-loop; other site
498216000105	ATP binding site [chemical binding]; other site
498216000106	Q-loop/lid; other site
498216000107	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
498216000108	ABC transporter signature motif; other site
498216000109	Walker B; other site
498216000110	D-loop; other site
498216000111	H-loop/switch region; other site
498216000112	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
498216000113	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
498216000114	Mg2+ binding site [ion binding]; other site
498216000115	G-X-G motif; other site
498216000116	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
498216000117	anchoring element; other site
498216000118	dimer interface [polypeptide binding]; other site
498216000119	ATP binding site [chemical binding]; other site
498216000120	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
498216000121	active site
498216000122	metal binding site [ion binding]; metal-binding site
498216000123	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
498216000124	DNA gyrase subunit A; Validated; Region: PRK05560
498216000125	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
498216000126	CAP-like domain; other site
498216000127	active site
498216000128	primary dimer interface [polypeptide binding]; other site
498216000129	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
498216000130	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
498216000131	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
498216000132	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
498216000133	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
498216000134	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
498216000135	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
498216000136	intersubunit interface [polypeptide binding]; other site
498216000137	active site
498216000138	catalytic residue [active]
498216000139	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
498216000140	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
498216000141	dimer interface [polypeptide binding]; other site
498216000142	ssDNA binding site [nucleotide binding]; other site
498216000143	tetramer (dimer of dimers) interface [polypeptide binding]; other site
498216000144	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
498216000145	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
498216000146	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
498216000147	dimer interface [polypeptide binding]; other site
498216000148	ssDNA binding site [nucleotide binding]; other site
498216000149	tetramer (dimer of dimers) interface [polypeptide binding]; other site
498216000150	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
498216000151	cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097
498216000152	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
498216000153	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
498216000154	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
498216000155	Protein of unknown function (DUF1211); Region: DUF1211; cl01421
498216000156	CAAX protease self-immunity; Region: Abi; pfam02517
498216000157	TPR/MLP1/MLP2-like protein; Region: TPR_MLP1_2; pfam07926
498216000158	CHAP domain; Region: CHAP; pfam05257
498216000159	Surface antigen [General function prediction only]; Region: COG3942
498216000160	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
498216000161	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
498216000162	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
498216000163	FtsX-like permease family; Region: FtsX; pfam02687
498216000164	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
498216000165	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
498216000166	Walker A/P-loop; other site
498216000167	ATP binding site [chemical binding]; other site
498216000168	Q-loop/lid; other site
498216000169	ABC transporter signature motif; other site
498216000170	Walker B; other site
498216000171	D-loop; other site
498216000172	H-loop/switch region; other site
498216000173	probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366
498216000174	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
498216000175	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
498216000176	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
498216000177	active site
498216000178	motif I; other site
498216000179	motif II; other site
498216000180	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
498216000181	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
498216000182	BacA is a bacterial lysin from Enterococcus faecalis that degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. BacA is homologous to the YbfG and YkuG lysins of...; Region: GH25_BacA-like; cd06418
498216000183	active site
498216000184	hypothetical protein; Provisional; Region: PRK10621
498216000185	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
498216000186	Protein of unknown function (DUF1211); Region: DUF1211; cl01421
498216000187	Rhomboid family; Region: Rhomboid; cl11446
498216000188	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
498216000189	uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827
498216000190	Cl binding site [ion binding]; other site
498216000191	oligomer interface [polypeptide binding]; other site
498216000192	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
498216000193	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
498216000194	manganese transport protein MntH; Reviewed; Region: PRK00701
498216000195	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
498216000196	Peptidase family C69; Region: Peptidase_C69; pfam03577
498216000197	Enterocin A Immunity; Region: EntA_Immun; pfam08951
498216000198	Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843
498216000199	Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296
498216000200	Predicted membrane protein [Function unknown]; Region: COG4392
498216000201	CAAX protease self-immunity; Region: Abi; pfam02517
498216000202	2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800
498216000203	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
498216000204	active site
498216000205	intersubunit interface [polypeptide binding]; other site
498216000206	catalytic residue [active]
498216000207	Transcriptional regulators [Transcription]; Region: GntR; COG1802
498216000208	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
498216000209	DNA-binding site [nucleotide binding]; DNA binding site
498216000210	FCD domain; Region: FCD; pfam07729
498216000211	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
498216000212	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
498216000213	non-specific DNA binding site [nucleotide binding]; other site
498216000214	salt bridge; other site
498216000215	sequence-specific DNA binding site [nucleotide binding]; other site
498216000216	transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716
498216000217	thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868
498216000218	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
498216000219	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
498216000220	Walker A/P-loop; other site
498216000221	ATP binding site [chemical binding]; other site
498216000222	Q-loop/lid; other site
498216000223	ABC transporter signature motif; other site
498216000224	Walker B; other site
498216000225	D-loop; other site
498216000226	H-loop/switch region; other site
498216000227	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
498216000228	Major Facilitator Superfamily; Region: MFS_1; pfam07690
498216000229	putative substrate translocation pore; other site
498216000230	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
498216000231	Predicted membrane protein [General function prediction only]; Region: COG4194
498216000232	Helix-turn-helix domain; Region: HTH_28; pfam13518
498216000233	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
498216000234	Transposase; Region: HTH_Tnp_1; pfam01527
498216000235	Helix-turn-helix domain; Region: HTH_28; pfam13518
498216000236	Winged helix-turn helix; Region: HTH_29; pfam13551
498216000237	putative transposase OrfB; Reviewed; Region: PHA02517
498216000238	HTH-like domain; Region: HTH_21; pfam13276
498216000239	Integrase core domain; Region: rve; pfam00665
498216000240	Integrase core domain; Region: rve_2; pfam13333
498216000241	MMPL family; Region: MMPL; pfam03176
498216000242	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
498216000243	transcriptional repressor BetI; Region: betaine_BetI; TIGR03384
498216000244	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
498216000245	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
498216000246	putative PBP binding loops; other site
498216000247	dimer interface [polypeptide binding]; other site
498216000248	ABC-ATPase subunit interface; other site
498216000249	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
498216000250	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
498216000251	dimer interface [polypeptide binding]; other site
498216000252	conserved gate region; other site
498216000253	putative PBP binding loops; other site
498216000254	ABC-ATPase subunit interface; other site
498216000255	ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295
498216000256	glycine betaine/L-proline transport ATP binding subunit; Region: proV; TIGR01186
498216000257	Walker A/P-loop; other site
498216000258	ATP binding site [chemical binding]; other site
498216000259	Q-loop/lid; other site
498216000260	ABC transporter signature motif; other site
498216000261	Walker B; other site
498216000262	D-loop; other site
498216000263	H-loop/switch region; other site
498216000264	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583
498216000265	CAAX protease self-immunity; Region: Abi; pfam02517
498216000266	heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525
498216000267	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
498216000268	Soluble P-type ATPase [General function prediction only]; Region: COG4087
498216000269	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
498216000270	metal-binding site [ion binding]
498216000271	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
498216000272	dinuclear metal binding motif [ion binding]; other site
498216000273	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
498216000274	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
498216000275	ligand binding site [chemical binding]; other site
498216000276	flexible hinge region; other site
498216000277	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
498216000278	putative switch regulator; other site
498216000279	non-specific DNA interactions [nucleotide binding]; other site
498216000280	DNA binding site [nucleotide binding]
498216000281	sequence specific DNA binding site [nucleotide binding]; other site
498216000282	putative cAMP binding site [chemical binding]; other site
498216000283	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
498216000284	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
498216000285	substrate binding site [chemical binding]; other site
498216000286	active site
498216000287	catalytic residues [active]
498216000288	heterodimer interface [polypeptide binding]; other site
498216000289	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
498216000290	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
498216000291	pyridoxal 5'-phosphate binding site [chemical binding]; other site
498216000292	catalytic residue [active]
498216000293	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
498216000294	active site
498216000295	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
498216000296	active site
498216000297	ribulose/triose binding site [chemical binding]; other site
498216000298	phosphate binding site [ion binding]; other site
498216000299	substrate (anthranilate) binding pocket [chemical binding]; other site
498216000300	product (indole) binding pocket [chemical binding]; other site
498216000301	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
498216000302	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
498216000303	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
498216000304	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
498216000305	Major Facilitator Superfamily; Region: MFS_1; pfam07690
498216000306	putative substrate translocation pore; other site
498216000307	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
498216000308	putative substrate translocation pore; other site
498216000309	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
498216000310	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
498216000311	gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740
498216000312	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
498216000313	Walker A/P-loop; other site
498216000314	ATP binding site [chemical binding]; other site
498216000315	Q-loop/lid; other site
498216000316	ABC transporter signature motif; other site
498216000317	Walker B; other site
498216000318	D-loop; other site
498216000319	H-loop/switch region; other site
498216000320	PemK-like protein; Region: PemK; pfam02452
498216000321	Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877
498216000322	potential frameshift: common BLAST hit: gi|191636854|ref|YP_001986020.1| YbfG
498216000323	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
498216000324	Transposase; Region: DDE_Tnp_ISL3; pfam01610
498216000325	dihydrodipicolinate reductase; Provisional; Region: PRK00048
498216000326	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
498216000327	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
498216000328	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
498216000329	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
498216000330	dimer interface [polypeptide binding]; other site
498216000331	active site
498216000332	catalytic residue [active]
498216000333	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
498216000334	M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670
498216000335	metal binding site [ion binding]; metal-binding site
498216000336	putative dimer interface [polypeptide binding]; other site
498216000337	Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503
498216000338	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532
498216000339	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
498216000340	putative trimer interface [polypeptide binding]; other site
498216000341	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
498216000342	putative CoA binding site [chemical binding]; other site
498216000343	putative trimer interface [polypeptide binding]; other site
498216000344	putative CoA binding site [chemical binding]; other site
498216000345	diaminopimelate decarboxylase; Region: lysA; TIGR01048
498216000346	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
498216000347	active site
498216000348	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
498216000349	substrate binding site [chemical binding]; other site
498216000350	catalytic residues [active]
498216000351	dimer interface [polypeptide binding]; other site
498216000352	aspartate kinase; Reviewed; Region: PRK09034
498216000353	AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245
498216000354	putative catalytic residues [active]
498216000355	putative nucleotide binding site [chemical binding]; other site
498216000356	putative aspartate binding site [chemical binding]; other site
498216000357	ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911
498216000358	allosteric regulatory residue; other site
498216000359	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
498216000360	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
498216000361	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
498216000362	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
498216000363	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
498216000364	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
498216000365	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665
498216000366	nudix motif; other site
498216000367	EamA-like transporter family; Region: EamA; cl17759
498216000368	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
498216000369	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
498216000370	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
498216000371	Walker A/P-loop; other site
498216000372	ATP binding site [chemical binding]; other site
498216000373	Q-loop/lid; other site
498216000374	ABC transporter signature motif; other site
498216000375	Walker B; other site
498216000376	D-loop; other site
498216000377	H-loop/switch region; other site
498216000378	PLA2_like: Phospholipase A2, a super-family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a...; Region: PLA2_like; cl05417
498216000379	catalytic residues [active]
498216000380	Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967
498216000381	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
498216000382	DHH family; Region: DHH; pfam01368
498216000383	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
498216000384	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
498216000385	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
498216000386	replicative DNA helicase; Provisional; Region: PRK05748
498216000387	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
498216000388	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
498216000389	Walker A motif; other site
498216000390	ATP binding site [chemical binding]; other site
498216000391	Walker B motif; other site
498216000392	DNA binding loops [nucleotide binding]
498216000393	PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995
498216000394	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
498216000395	active site turn [active]
498216000396	phosphorylation site [posttranslational modification]
498216000397	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
498216000398	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
498216000399	HPr interaction site; other site
498216000400	glycerol kinase (GK) interaction site [polypeptide binding]; other site
498216000401	active site
498216000402	phosphorylation site [posttranslational modification]
498216000403	N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441
498216000404	N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007
498216000405	putative active site [active]
498216000406	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
498216000407	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
498216000408	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
498216000409	putative active site [active]
498216000410	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
498216000411	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
498216000412	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
498216000413	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
498216000414	Walker A/P-loop; other site
498216000415	ATP binding site [chemical binding]; other site
498216000416	Q-loop/lid; other site
498216000417	ABC transporter signature motif; other site
498216000418	Walker B; other site
498216000419	D-loop; other site
498216000420	H-loop/switch region; other site
498216000421	FtsX-like permease family; Region: FtsX; pfam02687
498216000422	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
498216000423	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
498216000424	FtsX-like permease family; Region: FtsX; pfam02687
498216000425	Amidohydrolase; Region: Amidohydro_2; pfam04909
498216000426	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
498216000427	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
498216000428	GDP-binding site [chemical binding]; other site
498216000429	ACT binding site; other site
498216000430	IMP binding site; other site
498216000431	heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512
498216000432	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
498216000433	Soluble P-type ATPase [General function prediction only]; Region: COG4087
498216000434	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
498216000435	dimerization interface [polypeptide binding]; other site
498216000436	putative DNA binding site [nucleotide binding]; other site
498216000437	putative Zn2+ binding site [ion binding]; other site
498216000438	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
498216000439	plasma-membrane proton-efflux P-type ATPase; Region: ATPase-IIIA_H; TIGR01647
498216000440	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
498216000441	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
498216000442	Transcriptional regulator [Transcription]; Region: LysR; COG0583
498216000443	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
498216000444	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
498216000445	dimerization interface [polypeptide binding]; other site
498216000446	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
498216000447	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
498216000448	non-specific DNA binding site [nucleotide binding]; other site
498216000449	salt bridge; other site
498216000450	sequence-specific DNA binding site [nucleotide binding]; other site
498216000451	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
498216000452	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
498216000453	gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740
498216000454	Walker A/P-loop; other site
498216000455	ATP binding site [chemical binding]; other site
498216000456	Q-loop/lid; other site
498216000457	ABC transporter signature motif; other site
498216000458	Walker B; other site
498216000459	D-loop; other site
498216000460	H-loop/switch region; other site
498216000461	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
498216000462	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
498216000463	anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263
498216000464	ATP cone domain; Region: ATP-cone; pfam03477
498216000465	Class III ribonucleotide reductase; Region: RNR_III; cd01675
498216000466	effector binding site; other site
498216000467	active site
498216000468	Zn binding site [ion binding]; other site
498216000469	glycine loop; other site
498216000470	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
498216000471	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
498216000472	non-specific DNA binding site [nucleotide binding]; other site
498216000473	salt bridge; other site
498216000474	sequence-specific DNA binding site [nucleotide binding]; other site
498216000475	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
498216000476	Helix-turn-helix domain; Region: HTH_38; pfam13936
498216000477	Integrase core domain; Region: rve; pfam00665
498216000478	Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850
498216000479	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
498216000480	active site
498216000481	metal binding site [ion binding]; metal-binding site
498216000482	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
498216000483	FAD binding domain; Region: FAD_binding_4; pfam01565
498216000484	Protein of unknown function (DUF2089); Region: DUF2089; pfam09862
498216000485	PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396
498216000486	active site
498216000487	Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062
498216000488	putative dimer interface [polypeptide binding]; other site
498216000489	catalytic triad [active]
498216000490	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
498216000491	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
498216000492	ATP-grasp domain; Region: ATP-grasp_4; cl17255
498216000493	methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901
498216000494	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
498216000495	DNA binding site [nucleotide binding]
498216000496	active site
498216000497	D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186
498216000498	D-lactate dehydrogenase; Validated; Region: PRK08605
498216000499	homodimer interface [polypeptide binding]; other site
498216000500	ligand binding site [chemical binding]; other site
498216000501	NAD binding site [chemical binding]; other site
498216000502	catalytic site [active]
498216000503	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
498216000504	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
498216000505	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
498216000506	NAD(P) binding site [chemical binding]; other site
498216000507	Protein of unknown function (DUF1304); Region: DUF1304; pfam06993
498216000508	Protein of unknown function (DUF1516); Region: DUF1516; pfam07457
498216000509	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
498216000510	DsrE/DsrF-like family; Region: DrsE; cl00672
498216000511	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
498216000512	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
498216000513	Walker A/P-loop; other site
498216000514	ATP binding site [chemical binding]; other site
498216000515	Q-loop/lid; other site
498216000516	ABC transporter signature motif; other site
498216000517	Walker B; other site
498216000518	D-loop; other site
498216000519	H-loop/switch region; other site
498216000520	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
498216000521	taurine ABC transporter, periplasmic binding protein; Region: taurine_ABC_bnd; TIGR01729
498216000522	substrate binding pocket [chemical binding]; other site
498216000523	membrane-bound complex binding site; other site
498216000524	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
498216000525	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
498216000526	dimer interface [polypeptide binding]; other site
498216000527	conserved gate region; other site
498216000528	putative PBP binding loops; other site
498216000529	ABC-ATPase subunit interface; other site
498216000530	CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385
498216000531	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
498216000532	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
498216000533	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
498216000534	active site residue [active]
498216000535	Sulphur transport; Region: Sulf_transp; pfam04143
498216000536	Transcriptional regulator [Transcription]; Region: LysR; COG0583
498216000537	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
498216000538	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
498216000539	dimerization interface [polypeptide binding]; other site
498216000540	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
498216000541	Helix-turn-helix domain; Region: HTH_38; pfam13936
498216000542	Integrase core domain; Region: rve; pfam00665
498216000543	Enterocin A Immunity; Region: EntA_Immun; pfam08951
498216000544	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
498216000545	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
498216000546	Zn binding site [ion binding]; other site
498216000547	C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347
498216000548	Zn binding site [ion binding]; other site
498216000549	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
498216000550	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
498216000551	WxL domain surface cell wall-binding; Region: WxL; pfam13731
498216000552	WxL domain surface cell wall-binding; Region: WxL; pfam13731
498216000553	Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030
498216000554	Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797
498216000555	Mga helix-turn-helix domain; Region: Mga; pfam05043
498216000556	Protein of unknown function (DUF805); Region: DUF805; pfam05656
498216000557	Protein of unknown function (DUF805); Region: DUF805; pfam05656
498216000558	recombination factor protein RarA; Reviewed; Region: PRK13342
498216000559	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
498216000560	Walker A motif; other site
498216000561	ATP binding site [chemical binding]; other site
498216000562	Walker B motif; other site
498216000563	arginine finger; other site
498216000564	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
498216000565	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
498216000566	propionate/acetate kinase; Provisional; Region: PRK12379
498216000567	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
498216000568	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
498216000569	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
498216000570	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
498216000571	FGGY family of carbohydrate kinases; Region: FGGY; cd00366
498216000572	N- and C-terminal domain interface [polypeptide binding]; other site
498216000573	active site
498216000574	MgATP binding site [chemical binding]; other site
498216000575	catalytic site [active]
498216000576	metal binding site [ion binding]; metal-binding site
498216000577	carbohydrate binding site [chemical binding]; other site
498216000578	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
498216000579	intersubunit interface [polypeptide binding]; other site
498216000580	active site
498216000581	zinc binding site [ion binding]; other site
498216000582	Na+ binding site [ion binding]; other site
498216000583	PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410
498216000584	phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144
498216000585	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
498216000586	active site
498216000587	metal binding site [ion binding]; metal-binding site
498216000588	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
498216000589	endonuclease III; Region: ENDO3c; smart00478
498216000590	minor groove reading motif; other site
498216000591	helix-hairpin-helix signature motif; other site
498216000592	substrate binding pocket [chemical binding]; other site
498216000593	active site
498216000594	Domain of unknown function DUF77; Region: DUF77; pfam01910
498216000595	Predicted membrane protein [Function unknown]; Region: COG1511
498216000596	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
498216000597	X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057
498216000598	X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057
498216000599	X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057
498216000600	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
498216000601	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
498216000602	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
498216000603	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
498216000604	Major Facilitator Superfamily; Region: MFS_1; pfam07690
498216000605	putative substrate translocation pore; other site
498216000606	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
498216000607	putative phosphoketolase; Provisional; Region: PRK05261
498216000608	Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011
498216000609	TPP-binding site; other site
498216000610	XFP C-terminal domain; Region: XFP_C; pfam09363
498216000611	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
498216000612	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
498216000613	peptide binding site [polypeptide binding]; other site
498216000614	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
498216000615	nudix motif; other site
498216000616	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
498216000617	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
498216000618	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
498216000619	Walker A/P-loop; other site
498216000620	ATP binding site [chemical binding]; other site
498216000621	Q-loop/lid; other site
498216000622	ABC transporter signature motif; other site
498216000623	Walker B; other site
498216000624	D-loop; other site
498216000625	H-loop/switch region; other site
498216000626	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
498216000627	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
498216000628	non-specific DNA binding site [nucleotide binding]; other site
498216000629	salt bridge; other site
498216000630	sequence-specific DNA binding site [nucleotide binding]; other site
498216000631	transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716
498216000632	FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454
498216000633	coenzyme A disulfide reductase; Reviewed; Region: PRK09564
498216000634	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
498216000635	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
498216000636	Repair protein; Region: Repair_PSII; pfam04536
498216000637	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
498216000638	Protein of unknown function (DUF1634); Region: DUF1634; pfam07843
498216000639	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
498216000640	Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_13; cd12178
498216000641	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
498216000642	putative ligand binding site [chemical binding]; other site
498216000643	putative NAD binding site [chemical binding]; other site
498216000644	catalytic site [active]
498216000645	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
498216000646	Predicted membrane protein [Function unknown]; Region: COG2261
498216000647	Small integral membrane protein (DUF2273); Region: DUF2273; pfam10031
498216000648	Asp23 family; Region: Asp23; pfam03780
498216000649	Asp23 family; Region: Asp23; pfam03780
498216000650	Protein of unknown function (DUF969); Region: DUF969; pfam06149
498216000651	Predicted membrane protein [Function unknown]; Region: COG3817
498216000652	Protein of unknown function (DUF979); Region: DUF979; pfam06166
498216000653	Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I:  Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501
498216000654	putative substrate binding pocket [chemical binding]; other site
498216000655	AC domain interface; other site
498216000656	catalytic triad [active]
498216000657	AB domain interface; other site
498216000658	interchain disulfide; other site
498216000659	Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085
498216000660	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807
498216000661	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
498216000662	catalytic triad [active]
498216000663	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
498216000664	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
498216000665	S-adenosylmethionine binding site [chemical binding]; other site
498216000666	nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285
498216000667	ParB-like nuclease domain; Region: ParBc; pfam02195
498216000668	KorB domain; Region: KorB; pfam08535
498216000669	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
498216000670	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
498216000671	P-loop; other site
498216000672	Magnesium ion binding site [ion binding]; other site
498216000673	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
498216000674	Magnesium ion binding site [ion binding]; other site
498216000675	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
498216000676	ParB-like nuclease domain; Region: ParB; smart00470
498216000677	KorB domain; Region: KorB; pfam08535
498216000678	Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107
498216000679	GTP-binding protein YchF; Reviewed; Region: PRK09601
498216000680	YchF GTPase; Region: YchF; cd01900
498216000681	G1 box; other site
498216000682	GTP/Mg2+ binding site [chemical binding]; other site
498216000683	Switch I region; other site
498216000684	G2 box; other site
498216000685	Switch II region; other site
498216000686	G3 box; other site
498216000687	G4 box; other site
498216000688	G5 box; other site
498216000689	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
498216000690	Protein of unknown function (DUF1129); Region: DUF1129; pfam06570
498216000691	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
498216000692	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
498216000693	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
498216000694	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
498216000695	active site
498216000696	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
498216000697	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
498216000698	active site
498216000699	phosphorylation site [posttranslational modification]
498216000700	intermolecular recognition site; other site
498216000701	dimerization interface [polypeptide binding]; other site
498216000702	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
498216000703	DNA binding site [nucleotide binding]
498216000704	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
498216000705	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
498216000706	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
498216000707	dimer interface [polypeptide binding]; other site
498216000708	phosphorylation site [posttranslational modification]
498216000709	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
498216000710	ATP binding site [chemical binding]; other site
498216000711	Mg2+ binding site [ion binding]; other site
498216000712	G-X-G motif; other site
498216000713	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
498216000714	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
498216000715	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
498216000716	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
498216000717	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
498216000718	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
498216000719	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
498216000720	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
498216000721	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
498216000722	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
498216000723	aspartate racemase; Region: asp_race; TIGR00035
498216000724	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
498216000725	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
498216000726	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
498216000727	active site
498216000728	catalytic tetrad [active]
498216000729	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
498216000730	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
498216000731	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
498216000732	Sugar (and other) transporter; Region: Sugar_tr; pfam00083
498216000733	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
498216000734	putative substrate translocation pore; other site
498216000735	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
498216000736	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
498216000737	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
498216000738	tetrameric interface [polypeptide binding]; other site
498216000739	NAD binding site [chemical binding]; other site
498216000740	catalytic residues [active]
498216000741	Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718
498216000742	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
498216000743	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
498216000744	substrate binding site [chemical binding]; other site
498216000745	ATP binding site [chemical binding]; other site
498216000746	Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962
498216000747	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
498216000748	PYR/PP interface [polypeptide binding]; other site
498216000749	dimer interface [polypeptide binding]; other site
498216000750	TPP binding site [chemical binding]; other site
498216000751	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
498216000752	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
498216000753	TPP-binding site [chemical binding]; other site
498216000754	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
498216000755	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
498216000756	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
498216000757	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
498216000758	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
498216000759	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
498216000760	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
498216000761	Fructose-bisphosphate aldolase class-II; Region: F_bP_aldolase; pfam01116
498216000762	active site
498216000763	intersubunit interface [polypeptide binding]; other site
498216000764	zinc binding site [ion binding]; other site
498216000765	Na+ binding site [ion binding]; other site
498216000766	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
498216000767	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
498216000768	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
498216000769	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
498216000770	putative active site [active]
498216000771	Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023
498216000772	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
498216000773	gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314
498216000774	Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770
498216000775	N- and C-terminal domain interface [polypeptide binding]; other site
498216000776	active site
498216000777	catalytic site [active]
498216000778	metal binding site [ion binding]; metal-binding site
498216000779	carbohydrate binding site [chemical binding]; other site
498216000780	ATP binding site [chemical binding]; other site
498216000781	fructuronate transporter; Provisional; Region: PRK10034; cl15264
498216000782	Citrate transporter; Region: CitMHS; pfam03600
498216000783	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
498216000784	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
498216000785	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
498216000786	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
498216000787	putative PBP binding regions; other site
498216000788	ABC-ATPase subunit  interface; other site
498216000789	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
498216000790	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
498216000791	active site
498216000792	metal binding site [ion binding]; metal-binding site
498216000793	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
498216000794	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
498216000795	oligoendopeptidase F; Region: pepF; TIGR00181
498216000796	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608
498216000797	active site
498216000798	Zn binding site [ion binding]; other site
498216000799	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581
498216000800	Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547
498216000801	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
498216000802	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
498216000803	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
498216000804	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
498216000805	active site
498216000806	Protein of unknown function (DUF975); Region: DUF975; cl10504
498216000807	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
498216000808	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
498216000809	Catalytic site [active]
498216000810	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
498216000811	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747
498216000812	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
498216000813	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
498216000814	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
498216000815	ABC transporter; Region: ABC_tran_2; pfam12848
498216000816	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
498216000817	SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500
498216000818	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
498216000819	S-adenosylmethionine binding site [chemical binding]; other site
498216000820	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
498216000821	catalytic residues [active]
498216000822	Uncharacterized conserved protein [Function unknown]; Region: COG2966
498216000823	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
498216000824	Protein of unknown function (DUF3815); Region: DUF3815; pfam12821
498216000825	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
498216000826	Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347
498216000827	putative ligand binding site [chemical binding]; other site
498216000828	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
498216000829	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
498216000830	TM-ABC transporter signature motif; other site
498216000831	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
498216000832	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
498216000833	TM-ABC transporter signature motif; other site
498216000834	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
498216000835	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
498216000836	Walker A/P-loop; other site
498216000837	ATP binding site [chemical binding]; other site
498216000838	Q-loop/lid; other site
498216000839	ABC transporter signature motif; other site
498216000840	Walker B; other site
498216000841	D-loop; other site
498216000842	H-loop/switch region; other site
498216000843	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
498216000844	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
498216000845	Walker A/P-loop; other site
498216000846	ATP binding site [chemical binding]; other site
498216000847	Q-loop/lid; other site
498216000848	ABC transporter signature motif; other site
498216000849	Walker B; other site
498216000850	D-loop; other site
498216000851	H-loop/switch region; other site
498216000852	Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028
498216000853	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
498216000854	Class I aldolases; Region: Aldolase_Class_I; cl17187
498216000855	catalytic residue [active]
498216000856	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
498216000857	intersubunit interface [polypeptide binding]; other site
498216000858	active site
498216000859	catalytic residue [active]
498216000860	phosphopentomutase; Provisional; Region: PRK05362
498216000861	Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676
498216000862	purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819
498216000863	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
498216000864	NlpC/P60 family; Region: NLPC_P60; pfam00877
498216000865	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
498216000866	coenzyme A disulfide reductase; Reviewed; Region: PRK09564
498216000867	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
498216000868	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
498216000869	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
498216000870	DEAD/DEAH box helicase; Region: DEAD; pfam00270
498216000871	DEAD_2; Region: DEAD_2; pfam06733
498216000872	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
498216000873	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
498216000874	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
498216000875	Glycosyl hydrolase family 20 (GH20) catalytic domain of dispersin B (DspB), lacto-N-biosidase (LnbB) and related proteins. Dispersin B is a soluble beta-N-acetylglucosamidase found in bacteria that hydrolyzes the beta-1,6-linkages of PGA (poly-beta-(1,6)...; Region: GH20_DspB_LnbB-like; cd06564
498216000876	active site
498216000877	Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482
498216000878	mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218
498216000879	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
498216000880	Homeodomain-like domain; Region: HTH_23; pfam13384
498216000881	Transposase; Region: DDE_Tnp_ISL3; pfam01610
498216000882	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
498216000883	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
498216000884	DNA-binding site [nucleotide binding]; DNA binding site
498216000885	UTRA domain; Region: UTRA; pfam07702
498216000886	putative sugar isomerase, AgaS family; Region: agaS_fam; TIGR02815
498216000887	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
498216000888	dimer interface [polypeptide binding]; other site
498216000889	active site
498216000890	AgaS-like protein. AgaS contains a SIS (Sugar ISomerase) domain which is found in many phosphosugar isomerases and phosphosugar binding proteins. AgaS is a putative isomerase in Escherichia coli. It is similar to the glucosamine-6-phosphate synthases; Region: SIS_AgaS_like; cd05010
498216000891	putative active site [active]
498216000892	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
498216000893	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
498216000894	active site
498216000895	dimer interface [polypeptide binding]; other site
498216000896	Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301
498216000897	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
498216000898	active site
498216000899	phosphorylation site [posttranslational modification]
498216000900	PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609
498216000901	PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613
498216000902	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
498216000903	active pocket/dimerization site; other site
498216000904	active site
498216000905	phosphorylation site [posttranslational modification]
498216000906	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
498216000907	tagatose-6-phosphate kinase; Region: lacC; TIGR01231
498216000908	putative substrate binding site [chemical binding]; other site
498216000909	putative ATP binding site [chemical binding]; other site
498216000910	sorbitol-6-phosphate 2-dehydrogenase; Provisional; Region: PRK06171
498216000911	classical (c) SDRs; Region: SDR_c; cd05233
498216000912	NAD(P) binding site [chemical binding]; other site
498216000913	active site
498216000914	Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775
498216000915	PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451
498216000916	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
498216000917	active site
498216000918	phosphorylation site [posttranslational modification]
498216000919	PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS).  In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566
498216000920	active site
498216000921	P-loop; other site
498216000922	phosphorylation site [posttranslational modification]
498216000923	Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; pfam10087
498216000924	Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168
498216000925	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
498216000926	pyridoxal 5'-phosphate binding site [chemical binding]; other site
498216000927	homodimer interface [polypeptide binding]; other site
498216000928	catalytic residue [active]
498216000929	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
498216000930	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
498216000931	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
498216000932	active site
498216000933	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
498216000934	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
498216000935	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
498216000936	active site
498216000937	P-loop; other site
498216000938	phosphorylation site [posttranslational modification]
498216000939	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
498216000940	active site
498216000941	methionine cluster; other site
498216000942	phosphorylation site [posttranslational modification]
498216000943	metal binding site [ion binding]; metal-binding site
498216000944	exoaminopeptidase; Provisional; Region: PRK09961
498216000945	M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656
498216000946	oligomer interface [polypeptide binding]; other site
498216000947	active site
498216000948	metal binding site [ion binding]; metal-binding site
498216000949	HTH domain; Region: HTH_11; pfam08279
498216000950	PRD domain; Region: PRD; pfam00874
498216000951	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
498216000952	active site
498216000953	P-loop; other site
498216000954	phosphorylation site [posttranslational modification]
498216000955	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
498216000956	active site
498216000957	phosphorylation site [posttranslational modification]
498216000958	peptidase T; Region: peptidase-T; TIGR01882
498216000959	M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892
498216000960	metal binding site [ion binding]; metal-binding site
498216000961	dimer interface [polypeptide binding]; other site
498216000962	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
498216000963	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
498216000964	peptide binding site [polypeptide binding]; other site
498216000965	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
498216000966	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
498216000967	Coenzyme A binding pocket [chemical binding]; other site
498216000968	ABC-type cobalt transport system, permease component; Region: ABC_cobalt; cl01943
498216000969	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
498216000970	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
498216000971	Walker A/P-loop; other site
498216000972	ATP binding site [chemical binding]; other site
498216000973	Q-loop/lid; other site
498216000974	ABC transporter signature motif; other site
498216000975	Walker B; other site
498216000976	D-loop; other site
498216000977	H-loop/switch region; other site
498216000978	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
498216000979	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
498216000980	Walker A/P-loop; other site
498216000981	ATP binding site [chemical binding]; other site
498216000982	Q-loop/lid; other site
498216000983	ABC transporter signature motif; other site
498216000984	Walker B; other site
498216000985	D-loop; other site
498216000986	H-loop/switch region; other site
498216000987	Cobalt transport protein; Region: CbiQ; cl00463
498216000988	Putative transcription activator [Transcription]; Region: TenA; COG0819
498216000989	Thiamine-precursor transporter protein (ThiW); Region: ThiW; pfam09512
498216000990	4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170
498216000991	substrate binding site [chemical binding]; other site
498216000992	multimerization interface [polypeptide binding]; other site
498216000993	ATP binding site [chemical binding]; other site
498216000994	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
498216000995	thiamine phosphate binding site [chemical binding]; other site
498216000996	active site
498216000997	pyrophosphate binding site [ion binding]; other site
498216000998	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
498216000999	dimer interface [polypeptide binding]; other site
498216001000	substrate binding site [chemical binding]; other site
498216001001	ATP binding site [chemical binding]; other site
498216001002	Amino acid permease; Region: AA_permease_2; pfam13520
498216001003	Transcriptional regulators [Transcription]; Region: PurR; COG1609
498216001004	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
498216001005	DNA binding site [nucleotide binding]
498216001006	domain linker motif; other site
498216001007	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
498216001008	ligand binding site [chemical binding]; other site
498216001009	dimerization interface [polypeptide binding]; other site
498216001010	D-ribose pyranase; Provisional; Region: PRK11797
498216001011	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
498216001012	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
498216001013	Walker A/P-loop; other site
498216001014	ATP binding site [chemical binding]; other site
498216001015	Q-loop/lid; other site
498216001016	ABC transporter signature motif; other site
498216001017	Walker B; other site
498216001018	D-loop; other site
498216001019	H-loop/switch region; other site
498216001020	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
498216001021	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
498216001022	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
498216001023	TM-ABC transporter signature motif; other site
498216001024	Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323
498216001025	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
498216001026	ligand binding site [chemical binding]; other site
498216001027	dimerization interface [polypeptide binding]; other site
498216001028	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
498216001029	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
498216001030	substrate binding site [chemical binding]; other site
498216001031	dimer interface [polypeptide binding]; other site
498216001032	ATP binding site [chemical binding]; other site
498216001033	NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223
498216001034	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
498216001035	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
498216001036	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
498216001037	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
498216001038	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
498216001039	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
498216001040	dimer interface [polypeptide binding]; other site
498216001041	conserved gate region; other site
498216001042	ABC-ATPase subunit interface; other site
498216001043	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
498216001044	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
498216001045	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
498216001046	Walker A/P-loop; other site
498216001047	ATP binding site [chemical binding]; other site
498216001048	Q-loop/lid; other site
498216001049	ABC transporter signature motif; other site
498216001050	Walker B; other site
498216001051	D-loop; other site
498216001052	H-loop/switch region; other site
498216001053	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
498216001054	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
498216001055	NAD(P) binding site [chemical binding]; other site
498216001056	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
498216001057	Major Facilitator Superfamily; Region: MFS_1; pfam07690
498216001058	putative substrate translocation pore; other site
498216001059	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
498216001060	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
498216001061	MarR family; Region: MarR_2; pfam12802
498216001062	Rhomboid family; Region: Rhomboid; cl11446
498216001063	fumarate reductase flavoprotein subunit; Validated; Region: PRK06481
498216001064	L-aspartate oxidase; Provisional; Region: PRK06175
498216001065	Predicted oxidoreductase [General function prediction only]; Region: COG3573
498216001066	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
498216001067	Mga helix-turn-helix domain; Region: Mga; pfam05043
498216001068	PRD domain; Region: PRD; pfam00874
498216001069	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
498216001070	active site
498216001071	P-loop; other site
498216001072	phosphorylation site [posttranslational modification]
498216001073	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
498216001074	active site
498216001075	phosphorylation site [posttranslational modification]
498216001076	PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563
498216001077	active site
498216001078	P-loop; other site
498216001079	phosphorylation site [posttranslational modification]
498216001080	PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: PRK12997
498216001081	Fructose-bisphosphate aldolase class-II; Region: F_bP_aldolase; pfam01116
498216001082	active site
498216001083	intersubunit interface [polypeptide binding]; other site
498216001084	zinc binding site [ion binding]; other site
498216001085	Na+ binding site [ion binding]; other site
498216001086	AAA domain; Region: AAA_17; pfam13207
498216001087	AAA domain; Region: AAA_18; pfam13238
498216001088	Predicted transcriptional regulators [Transcription]; Region: COG1378
498216001089	Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978
498216001090	Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124
498216001091	C-terminal domain interface [polypeptide binding]; other site
498216001092	sugar binding site [chemical binding]; other site
498216001093	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
498216001094	ornithine cyclodeaminase; Validated; Region: PRK08618
498216001095	ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400
498216001096	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
498216001097	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
498216001098	KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715
498216001099	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
498216001100	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
498216001101	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
498216001102	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
498216001103	Helix-turn-helix domain; Region: HTH_38; pfam13936
498216001104	Integrase core domain; Region: rve; pfam00665
498216001105	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
498216001106	active site
498216001107	catalytic site [active]
498216001108	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
498216001109	Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929
498216001110	PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765
498216001111	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
498216001112	active site
498216001113	phosphorylation site [posttranslational modification]
498216001114	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
498216001115	active site
498216001116	P-loop; other site
498216001117	phosphorylation site [posttranslational modification]
498216001118	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
498216001119	alpha-mannosidase; Provisional; Region: PRK09819
498216001120	N-terminal catalytic domain of Escherichia coli alpha-mannosidase MngB and its bacterial homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_EcMngB_like; cd10815
498216001121	active site
498216001122	metal binding site [ion binding]; metal-binding site
498216001123	catalytic site [active]
498216001124	Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536
498216001125	Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482
498216001126	Uncharacterized conserved protein [Function unknown]; Region: COG1912
498216001127	hypothetical protein; Provisional; Region: PRK13661
498216001128	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
498216001129	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
498216001130	Walker A/P-loop; other site
498216001131	ATP binding site [chemical binding]; other site
498216001132	Q-loop/lid; other site
498216001133	ABC transporter signature motif; other site
498216001134	Walker B; other site
498216001135	D-loop; other site
498216001136	H-loop/switch region; other site
498216001137	ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558
498216001138	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
498216001139	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
498216001140	Walker A/P-loop; other site
498216001141	ATP binding site [chemical binding]; other site
498216001142	Q-loop/lid; other site
498216001143	ABC transporter signature motif; other site
498216001144	Walker B; other site
498216001145	D-loop; other site
498216001146	H-loop/switch region; other site
498216001147	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
498216001148	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
498216001149	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
498216001150	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221
498216001151	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
498216001152	Transcriptional antiterminator [Transcription]; Region: COG3933
498216001153	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025
498216001154	active pocket/dimerization site; other site
498216001155	active site
498216001156	phosphorylation site [posttranslational modification]
498216001157	PRD domain; Region: PRD; pfam00874
498216001158	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025
498216001159	active pocket/dimerization site; other site
498216001160	active site
498216001161	phosphorylation site [posttranslational modification]
498216001162	PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830
498216001163	active site
498216001164	phosphorylation site [posttranslational modification]
498216001165	PTS system sorbose-specific iic component; Region: EII-Sor; cl01506
498216001166	PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613
498216001167	KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715
498216001168	Glycosyl hydrolases family 32; Region: Glyco_32; smart00640
498216001169	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
498216001170	substrate binding [chemical binding]; other site
498216001171	active site
498216001172	Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244
498216001173	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
498216001174	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
498216001175	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
498216001176	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
498216001177	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
498216001178	beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009
498216001179	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
498216001180	motif II; other site
498216001181	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
498216001182	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
498216001183	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
498216001184	3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726
498216001185	active site
498216001186	dimer interface [polypeptide binding]; other site
498216001187	magnesium binding site [ion binding]; other site
498216001188	SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389
498216001189	PTS system mannitol-specific transporter subunit IICBA; Provisional; Region: PRK15083
498216001190	PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851
498216001191	PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567
498216001192	active site
498216001193	P-loop; other site
498216001194	phosphorylation site [posttranslational modification]
498216001195	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
498216001196	active site
498216001197	phosphorylation site [posttranslational modification]
498216001198	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
498216001199	mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318
498216001200	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
498216001201	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
498216001202	NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain; Region: Octopine_DH; pfam02317
498216001203	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
498216001204	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
498216001205	Walker A/P-loop; other site
498216001206	ATP binding site [chemical binding]; other site
498216001207	Q-loop/lid; other site
498216001208	ABC transporter signature motif; other site
498216001209	Walker B; other site
498216001210	D-loop; other site
498216001211	H-loop/switch region; other site
498216001212	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
498216001213	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
498216001214	substrate binding pocket [chemical binding]; other site
498216001215	membrane-bound complex binding site; other site
498216001216	hinge residues; other site
498216001217	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
498216001218	dimer interface [polypeptide binding]; other site
498216001219	conserved gate region; other site
498216001220	putative PBP binding loops; other site
498216001221	ABC-ATPase subunit interface; other site
498216001222	alpha-ketoglutarate transporter; Provisional; Region: PRK10406
498216001223	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
498216001224	putative substrate translocation pore; other site
498216001225	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
498216001226	YvrJ protein family; Region: YvrJ; pfam12841
498216001227	AtlA is an autolysin found in Gram-positive lactic acid bacteria that degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. This family includes the AtlA and Aml...; Region: GH25_AtlA-like; cd06522
498216001228	active site
498216001229	Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183
498216001230	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
498216001231	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
498216001232	classical (c) SDRs; Region: SDR_c; cd05233
498216001233	NAD(P) binding site [chemical binding]; other site
498216001234	active site
498216001235	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
498216001236	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
498216001237	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
498216001238	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
498216001239	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
498216001240	FtsX-like permease family; Region: FtsX; pfam02687
498216001241	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
498216001242	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
498216001243	Walker A/P-loop; other site
498216001244	ATP binding site [chemical binding]; other site
498216001245	Q-loop/lid; other site
498216001246	ABC transporter signature motif; other site
498216001247	Walker B; other site
498216001248	D-loop; other site
498216001249	H-loop/switch region; other site
498216001250	coenzyme A disulfide reductase; Reviewed; Region: PRK09564
498216001251	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
498216001252	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
498216001253	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
498216001254	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
498216001255	active site
498216001256	motif I; other site
498216001257	motif II; other site
498216001258	trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105
498216001259	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
498216001260	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041; cl17396
498216001261	Transcriptional regulators [Transcription]; Region: PurR; COG1609
498216001262	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
498216001263	DNA binding site [nucleotide binding]
498216001264	domain linker motif; other site
498216001265	Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286
498216001266	putative dimerization interface [polypeptide binding]; other site
498216001267	putative ligand binding site [chemical binding]; other site
498216001268	PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830
498216001269	active site
498216001270	phosphorylation site [posttranslational modification]
498216001271	PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609
498216001272	PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613
498216001273	Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501
498216001274	This family represents an uncharacterized glycosyl hydrolase family 31 (GH31) enzyme found in bacteria and eukaryotes that is related to the XylS xylosidase of Sulfolobus solfataricus. Alpha-xylosidases catalyze the release of an alpha-xylose residue...; Region: GH31_xylosidase_XylS-like; cd06595
498216001275	putative active site [active]
498216001276	putative catalytic site [active]
498216001277	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025
498216001278	active pocket/dimerization site; other site
498216001279	active site
498216001280	phosphorylation site [posttranslational modification]
498216001281	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
498216001282	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
498216001283	Ca binding site [ion binding]; other site
498216001284	active site
498216001285	catalytic site [active]
498216001286	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
498216001287	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
498216001288	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
498216001289	Walker A/P-loop; other site
498216001290	ATP binding site [chemical binding]; other site
498216001291	Q-loop/lid; other site
498216001292	ABC transporter signature motif; other site
498216001293	Walker B; other site
498216001294	D-loop; other site
498216001295	H-loop/switch region; other site
498216001296	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
498216001297	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
498216001298	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
498216001299	Walker A/P-loop; other site
498216001300	ATP binding site [chemical binding]; other site
498216001301	Q-loop/lid; other site
498216001302	ABC transporter signature motif; other site
498216001303	Walker B; other site
498216001304	D-loop; other site
498216001305	H-loop/switch region; other site
498216001306	Predicted membrane protein [Function unknown]; Region: COG1511
498216001307	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
498216001308	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
498216001309	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
498216001310	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
498216001311	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
498216001312	Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275
498216001313	active site
498216001314	myosin-cross-reactive antigen; Provisional; Region: PRK13977
498216001315	probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366
498216001316	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
498216001317	phosphotransferase mannnose-specific family component IIA; Provisional; Region: PRK14484
498216001318	DAK2 domain; Region: Dak2; cl03685
498216001319	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481
498216001320	Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376
498216001321	OsmC-like protein; Region: OsmC; cl00767
498216001322	Helix-turn-helix domain; Region: HTH_19; pfam12844
498216001323	transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716
498216001324	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
498216001325	active site
498216001326	catalytic site [active]
498216001327	substrate binding site [chemical binding]; other site
498216001328	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
498216001329	dimerization interface [polypeptide binding]; other site
498216001330	putative DNA binding site [nucleotide binding]; other site
498216001331	putative Zn2+ binding site [ion binding]; other site
498216001332	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
498216001333	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
498216001334	putative substrate translocation pore; other site
498216001335	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
498216001336	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
498216001337	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
498216001338	intersubunit interface [polypeptide binding]; other site
498216001339	active site
498216001340	zinc binding site [ion binding]; other site
498216001341	Na+ binding site [ion binding]; other site
498216001342	pyruvate oxidase; Provisional; Region: PRK08611
498216001343	Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039
498216001344	PYR/PP interface [polypeptide binding]; other site
498216001345	dimer interface [polypeptide binding]; other site
498216001346	tetramer interface [polypeptide binding]; other site
498216001347	TPP binding site [chemical binding]; other site
498216001348	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
498216001349	Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014
498216001350	TPP-binding site [chemical binding]; other site
498216001351	Beta-lactamase; Region: Beta-lactamase; pfam00144
498216001352	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
498216001353	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
498216001354	L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319
498216001355	active site
498216001356	Methyltransferase domain; Region: Methyltransf_31; pfam13847
498216001357	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
498216001358	S-adenosylmethionine binding site [chemical binding]; other site
498216001359	Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071
498216001360	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
498216001361	catalytic triad [active]
498216001362	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
498216001363	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
498216001364	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
498216001365	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
498216001366	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
498216001367	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
498216001368	DNA binding residues [nucleotide binding]
498216001369	putative dimer interface [polypeptide binding]; other site
498216001370	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
498216001371	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
498216001372	active site
498216001373	catalytic tetrad [active]
498216001374	Arginate lyase and other MDR family members; Region: AL_MDR; cd08252
498216001375	zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817
498216001376	putative NAD(P) binding site [chemical binding]; other site
498216001377	dimer interface [polypeptide binding]; other site
498216001378	Predicted transcriptional regulators [Transcription]; Region: COG1733
498216001379	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
498216001380	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
498216001381	beta-galactosidase; Region: BGL; TIGR03356
498216001382	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
498216001383	active site
498216001384	methionine cluster; other site
498216001385	phosphorylation site [posttranslational modification]
498216001386	metal binding site [ion binding]; metal-binding site
498216001387	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
498216001388	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
498216001389	active site
498216001390	P-loop; other site
498216001391	phosphorylation site [posttranslational modification]
498216001392	HTH domain; Region: HTH_11; cl17392
498216001393	Mga helix-turn-helix domain; Region: Mga; pfam05043
498216001394	PRD domain; Region: PRD; pfam00874
498216001395	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
498216001396	active site
498216001397	phosphorylation site [posttranslational modification]
498216001398	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
498216001399	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
498216001400	catalytic residues [active]
498216001401	catalytic nucleophile [active]
498216001402	Presynaptic Site I dimer interface [polypeptide binding]; other site
498216001403	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
498216001404	Synaptic Flat tetramer interface [polypeptide binding]; other site
498216001405	Synaptic Site I dimer interface [polypeptide binding]; other site
498216001406	DNA binding site [nucleotide binding]
498216001407	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
498216001408	metal ion-dependent adhesion site (MIDAS); other site
498216001409	Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222
498216001410	domain interaction interfaces [polypeptide binding]; other site
498216001411	Cna protein B-type domain; Region: Cna_B; pfam05738
498216001412	Cna protein B-type domain; Region: Cna_B; pfam05738
498216001413	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
498216001414	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
498216001415	Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827
498216001416	active site
498216001417	catalytic site [active]
498216001418	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
498216001419	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
498216001420	Walker A/P-loop; other site
498216001421	ATP binding site [chemical binding]; other site
498216001422	Q-loop/lid; other site
498216001423	ABC transporter signature motif; other site
498216001424	Walker B; other site
498216001425	D-loop; other site
498216001426	H-loop/switch region; other site
498216001427	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
498216001428	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
498216001429	active site
498216001430	phosphorylation site [posttranslational modification]
498216001431	intermolecular recognition site; other site
498216001432	dimerization interface [polypeptide binding]; other site
498216001433	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
498216001434	DNA binding site [nucleotide binding]
498216001435	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
498216001436	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
498216001437	dimerization interface [polypeptide binding]; other site
498216001438	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
498216001439	ATP binding site [chemical binding]; other site
498216001440	Mg2+ binding site [ion binding]; other site
498216001441	G-X-G motif; other site
498216001442	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
498216001443	ABC-type multidrug transport system, ATPase component; Region: ABC_drug_resistance_like; cd03264
498216001444	Walker A/P-loop; other site
498216001445	ATP binding site [chemical binding]; other site
498216001446	Q-loop/lid; other site
498216001447	ABC transporter signature motif; other site
498216001448	Walker B; other site
498216001449	D-loop; other site
498216001450	H-loop/switch region; other site
498216001451	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
498216001452	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
498216001453	Helix-turn-helix domain; Region: HTH_38; pfam13936
498216001454	Integrase core domain; Region: rve; pfam00665
498216001455	KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715
498216001456	Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475
498216001457	catalytic triad [active]
498216001458	putative active site [active]
498216001459	Fn3-like domain (DUF1034); Region: DUF1034; pfam06280
498216001460	KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715
498216001461	Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475
498216001462	catalytic triad [active]
498216001463	putative active site [active]
498216001464	Fn3-like domain (DUF1034); Region: DUF1034; pfam06280
498216001465	Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601
498216001466	Aminopeptidase N [Amino acid transport and metabolism]; Region: PepN; COG0308
498216001467	Zn binding site [ion binding]; other site
498216001468	inner membrane transporter YjeM; Provisional; Region: PRK15238
498216001469	Protein of unknown function (DUF1440); Region: DUF1440; pfam07274
498216001470	Transcriptional regulator [Transcription]; Region: LysR; COG0583
498216001471	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
498216001472	The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434
498216001473	putative dimerization interface [polypeptide binding]; other site
498216001474	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
498216001475	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
498216001476	classical (c) SDRs; Region: SDR_c; cd05233
498216001477	NAD(P) binding site [chemical binding]; other site
498216001478	active site
498216001479	shikimate 5-dehydrogenase; Provisional; Region: PRK12548
498216001480	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
498216001481	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
498216001482	shikimate binding site; other site
498216001483	NAD(P) binding site [chemical binding]; other site
498216001484	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
498216001485	putative substrate translocation pore; other site
498216001486	Major Facilitator Superfamily; Region: MFS_1; pfam07690
498216001487	shikimate 5-dehydrogenase; Provisional; Region: PRK12548
498216001488	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
498216001489	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
498216001490	shikimate binding site; other site
498216001491	NAD(P) binding site [chemical binding]; other site
498216001492	Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131
498216001493	proposed active site lysine [active]
498216001494	conserved cys residue [active]
498216001495	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
498216001496	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
498216001497	dimer interface [polypeptide binding]; other site
498216001498	pyridoxal 5'-phosphate binding site [chemical binding]; other site
498216001499	catalytic residue [active]
498216001500	Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053
498216001501	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
498216001502	homodimer interface [polypeptide binding]; other site
498216001503	substrate-cofactor binding pocket; other site
498216001504	pyridoxal 5'-phosphate binding site [chemical binding]; other site
498216001505	catalytic residue [active]
498216001506	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
498216001507	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
498216001508	substrate binding pocket [chemical binding]; other site
498216001509	membrane-bound complex binding site; other site
498216001510	hinge residues; other site
498216001511	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
498216001512	dimer interface [polypeptide binding]; other site
498216001513	conserved gate region; other site
498216001514	putative PBP binding loops; other site
498216001515	ABC-ATPase subunit interface; other site
498216001516	Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547
498216001517	WxL domain surface cell wall-binding; Region: WxL; pfam13731
498216001518	Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030
498216001519	Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797
498216001520	legume lectins; Region: lectin_L-type; cl14058
498216001521	homotetramer interaction site [polypeptide binding]; other site
498216001522	carbohydrate binding site [chemical binding]; other site
498216001523	metal binding site [ion binding]; metal-binding site
498216001524	WxL domain surface cell wall-binding; Region: WxL; pfam13731
498216001525	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
498216001526	Helix-turn-helix domain; Region: HTH_38; pfam13936
498216001527	Integrase core domain; Region: rve; pfam00665
498216001528	WxL domain surface cell wall-binding; Region: WxL; pfam13731
498216001529	WxL domain surface cell wall-binding; Region: WxL; pfam13731
498216001530	legume lectins; Region: lectin_L-type; cd01951
498216001531	homotetramer interaction site [polypeptide binding]; other site
498216001532	carbohydrate binding site [chemical binding]; other site
498216001533	metal binding site [ion binding]; metal-binding site
498216001534	WxL domain surface cell wall-binding; Region: WxL; pfam13731
498216001535	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
498216001536	EamA-like transporter family; Region: EamA; pfam00892
498216001537	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
498216001538	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
498216001539	Walker A/P-loop; other site
498216001540	ATP binding site [chemical binding]; other site
498216001541	Q-loop/lid; other site
498216001542	ABC transporter signature motif; other site
498216001543	Walker B; other site
498216001544	D-loop; other site
498216001545	H-loop/switch region; other site
498216001546	ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl17272
498216001547	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
498216001548	substrate binding site [chemical binding]; other site
498216001549	ATP binding site [chemical binding]; other site
498216001550	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
498216001551	FAD binding site [chemical binding]; other site
498216001552	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222
498216001553	CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312
498216001554	THF binding site; other site
498216001555	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
498216001556	substrate binding site [chemical binding]; other site
498216001557	THF binding site; other site
498216001558	zinc-binding site [ion binding]; other site
498216001559	Uncharacterized distant relative of cell wall-associated hydrolases [Function unknown]; Region: COG3863
498216001560	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
498216001561	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
498216001562	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
498216001563	Walker A/P-loop; other site
498216001564	ATP binding site [chemical binding]; other site
498216001565	Q-loop/lid; other site
498216001566	ABC transporter signature motif; other site
498216001567	Walker B; other site
498216001568	D-loop; other site
498216001569	H-loop/switch region; other site
498216001570	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
498216001571	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
498216001572	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
498216001573	Walker A/P-loop; other site
498216001574	ATP binding site [chemical binding]; other site
498216001575	Q-loop/lid; other site
498216001576	ABC transporter signature motif; other site
498216001577	Walker B; other site
498216001578	D-loop; other site
498216001579	H-loop/switch region; other site
498216001580	oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890
498216001581	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
498216001582	putative substrate translocation pore; other site
498216001583	trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404
498216001584	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
498216001585	DNA-binding site [nucleotide binding]; DNA binding site
498216001586	UTRA domain; Region: UTRA; pfam07702
498216001587	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
498216001588	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
498216001589	Ca binding site [ion binding]; other site
498216001590	active site
498216001591	catalytic site [active]
498216001592	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
498216001593	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
498216001594	HPr interaction site; other site
498216001595	glycerol kinase (GK) interaction site [polypeptide binding]; other site
498216001596	active site
498216001597	phosphorylation site [posttranslational modification]
498216001598	PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996
498216001599	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
498216001600	active site turn [active]
498216001601	phosphorylation site [posttranslational modification]
498216001602	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
498216001603	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
498216001604	serine/threonine transporter SstT; Provisional; Region: PRK13628
498216001605	amino acid transporter; Region: 2A0306; TIGR00909
498216001606	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
498216001607	L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066
498216001608	L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291
498216001609	NAD binding site [chemical binding]; other site
498216001610	dimer interface [polypeptide binding]; other site
498216001611	tetramer (dimer of dimers) interface [polypeptide binding]; other site
498216001612	substrate binding site [chemical binding]; other site
498216001613	glutamate dehydrogenase; Provisional; Region: PRK09414
498216001614	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
498216001615	NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313
498216001616	NAD(P) binding site [chemical binding]; other site
498216001617	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
498216001618	DNA-binding site [nucleotide binding]; DNA binding site
498216001619	RNA-binding motif; other site
498216001620	Protein of unknown function (DUF3036); Region: DUF3036; pfam11234
498216001621	OsmC-like protein; Region: OsmC; pfam02566
498216001622	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
498216001623	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
498216001624	ABC transporter; Region: ABC_tran_2; pfam12848
498216001625	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
498216001626	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
498216001627	NADH(P)-binding; Region: NAD_binding_10; pfam13460
498216001628	NAD(P) binding site [chemical binding]; other site
498216001629	putative active site [active]
498216001630	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
498216001631	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
498216001632	active site
498216001633	catalytic tetrad [active]
498216001634	putative transport protein YifK; Provisional; Region: PRK10746
498216001635	Protein of unknown function (DUF3800); Region: DUF3800; pfam12686
498216001636	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
498216001637	Protein of unknown function (DUF3021); Region: DUF3021; pfam11457
498216001638	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
498216001639	LytTr DNA-binding domain; Region: LytTR; smart00850
498216001640	Predicted membrane protein [Function unknown]; Region: COG1511
498216001641	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
498216001642	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
498216001643	Walker A/P-loop; other site
498216001644	ATP binding site [chemical binding]; other site
498216001645	Q-loop/lid; other site
498216001646	ABC transporter signature motif; other site
498216001647	Walker B; other site
498216001648	D-loop; other site
498216001649	H-loop/switch region; other site
498216001650	Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028
498216001651	Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124
498216001652	active site
498216001653	zinc binding site [ion binding]; other site
498216001654	hypothetical protein; Provisional; Region: PRK00967
498216001655	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
498216001656	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
498216001657	putative NAD(P) binding site [chemical binding]; other site
498216001658	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
498216001659	Dyp-type peroxidase family; Region: Dyp_perox; cl01067
498216001660	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
498216001661	MgtC family; Region: MgtC; pfam02308
498216001662	DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; pfam13930
498216001663	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892
498216001664	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
498216001665	Helix-turn-helix domain; Region: HTH_38; pfam13936
498216001666	Integrase core domain; Region: rve; pfam00665
498216001667	Rhomboid family; Region: Rhomboid; cl11446
498216001668	ABC transporter ATP-binding protein; Provisional; Region: PRK15064
498216001669	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
498216001670	Walker A/P-loop; other site
498216001671	ATP binding site [chemical binding]; other site
498216001672	ABC transporter signature motif; other site
498216001673	Walker B; other site
498216001674	D-loop; other site
498216001675	H-loop/switch region; other site
498216001676	ABC transporter; Region: ABC_tran_2; pfam12848
498216001677	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
498216001678	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
498216001679	Walker A/P-loop; other site
498216001680	ATP binding site [chemical binding]; other site
498216001681	Q-loop/lid; other site
498216001682	ABC transporter signature motif; other site
498216001683	Walker B; other site
498216001684	D-loop; other site
498216001685	H-loop/switch region; other site
498216001686	Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033
498216001687	putative uracil binding site [chemical binding]; other site
498216001688	putative active site [active]
498216001689	Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580
498216001690	amphipathic channel; other site
498216001691	Asn-Pro-Ala signature motifs; other site
498216001692	glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266
498216001693	glycerol kinase; Provisional; Region: glpK; PRK00047
498216001694	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
498216001695	N- and C-terminal domain interface [polypeptide binding]; other site
498216001696	active site
498216001697	MgATP binding site [chemical binding]; other site
498216001698	catalytic site [active]
498216001699	metal binding site [ion binding]; metal-binding site
498216001700	glycerol binding site [chemical binding]; other site
498216001701	homotetramer interface [polypeptide binding]; other site
498216001702	homodimer interface [polypeptide binding]; other site
498216001703	FBP binding site [chemical binding]; other site
498216001704	protein IIAGlc interface [polypeptide binding]; other site
498216001705	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
498216001706	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
498216001707	active site
498216001708	galactokinase; Provisional; Region: PRK05322
498216001709	Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509
498216001710	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
498216001711	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
498216001712	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
498216001713	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
498216001714	NAD binding site [chemical binding]; other site
498216001715	homodimer interface [polypeptide binding]; other site
498216001716	active site
498216001717	substrate binding site [chemical binding]; other site
498216001718	galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270
498216001719	Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087
498216001720	Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744
498216001721	DNA-binding transcriptional repressor EbgR; Provisional; Region: PRK10339
498216001722	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
498216001723	DNA binding site [nucleotide binding]
498216001724	domain linker motif; other site
498216001725	Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544
498216001726	putative dimerization interface [polypeptide binding]; other site
498216001727	putative ligand binding site [chemical binding]; other site
498216001728	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
498216001729	active site
498216001730	catalytic residues [active]
498216001731	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
498216001732	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
498216001733	active site
498216001734	phosphorylation site [posttranslational modification]
498216001735	Phosphotransferase system, galactitol-specific IIB component [Carbohydrate transport and metabolism]; Region: SgaB; COG3414
498216001736	active site
498216001737	P-loop; other site
498216001738	phosphorylation site [posttranslational modification]
498216001739	Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775
498216001740	PTS system sugar-specific permease component; Region: EIIC-GAT; pfam03611
498216001741	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
498216001742	tagatose-6-phosphate kinase; Region: lacC; TIGR01231
498216001743	putative substrate binding site [chemical binding]; other site
498216001744	putative ATP binding site [chemical binding]; other site
498216001745	tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK12399
498216001746	galactose-6-phosphate isomerase subunit LacB; Reviewed; Region: PRK08622
498216001747	galactose-6-phosphate isomerase subunit LacA; Reviewed; Region: PRK08621
498216001748	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
498216001749	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
498216001750	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
498216001751	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
498216001752	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
498216001753	motif II; other site
498216001754	DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420
498216001755	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
498216001756	active site
498216001757	metal binding site [ion binding]; metal-binding site
498216001758	DNA binding site [nucleotide binding]
498216001759	Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320
498216001760	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
498216001761	AAA domain; Region: AAA_23; pfam13476
498216001762	Walker A/P-loop; other site
498216001763	ATP binding site [chemical binding]; other site
498216001764	Q-loop/lid; other site
498216001765	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419
498216001766	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
498216001767	ABC transporter signature motif; other site
498216001768	Walker B; other site
498216001769	D-loop; other site
498216001770	H-loop/switch region; other site
498216001771	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
498216001772	Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471
498216001773	putative dimer interface [polypeptide binding]; other site
498216001774	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
498216001775	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
498216001776	minor groove reading motif; other site
498216001777	helix-hairpin-helix signature motif; other site
498216001778	substrate binding pocket [chemical binding]; other site
498216001779	active site
498216001780	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
498216001781	DNA binding and oxoG recognition site [nucleotide binding]
498216001782	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
498216001783	Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525
498216001784	Short repeat of unknown function (DUF308); Region: DUF308; cl15828
498216001785	GyrI-like small molecule binding domain; Region: GyrI-like; cl01368
498216001786	Helix-turn-helix domain; Region: HTH_28; pfam13518
498216001787	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
498216001788	Transposase; Region: HTH_Tnp_1; pfam01527
498216001789	Helix-turn-helix domain; Region: HTH_28; pfam13518
498216001790	Winged helix-turn helix; Region: HTH_29; pfam13551
498216001791	putative transposase OrfB; Reviewed; Region: PHA02517
498216001792	HTH-like domain; Region: HTH_21; pfam13276
498216001793	Integrase core domain; Region: rve; pfam00665
498216001794	Integrase core domain; Region: rve_2; pfam13333
498216001795	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
498216001796	dimer interface [polypeptide binding]; other site
498216001797	substrate binding site [chemical binding]; other site
498216001798	ATP binding site [chemical binding]; other site
498216001799	biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244
498216001800	NADH(P)-binding; Region: NAD_binding_10; pfam13460
498216001801	NAD binding site [chemical binding]; other site
498216001802	substrate binding site [chemical binding]; other site
498216001803	putative active site [active]
498216001804	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
498216001805	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
498216001806	Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915
498216001807	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
498216001808	Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325
498216001809	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
498216001810	zinc binding site [ion binding]; other site
498216001811	putative ligand binding site [chemical binding]; other site
498216001812	Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325
498216001813	zinc binding site [ion binding]; other site
498216001814	putative ligand binding site [chemical binding]; other site
498216001815	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
498216001816	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574
498216001817	TM-ABC transporter signature motif; other site
498216001818	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101
498216001819	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
498216001820	Walker A/P-loop; other site
498216001821	ATP binding site [chemical binding]; other site
498216001822	Q-loop/lid; other site
498216001823	ABC transporter signature motif; other site
498216001824	Walker B; other site
498216001825	D-loop; other site
498216001826	H-loop/switch region; other site
498216001827	Yhdh and yhfp-like putative quinone oxidoreductases; Region: MDR_yhdh_yhfp; cd05280
498216001828	putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823
498216001829	NADP binding site [chemical binding]; other site
498216001830	dimer interface [polypeptide binding]; other site
498216001831	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
498216001832	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
498216001833	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
498216001834	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
498216001835	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
498216001836	motif II; other site
498216001837	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
498216001838	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
498216001839	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
498216001840	Ligand binding site; other site
498216001841	Putative Catalytic site; other site
498216001842	DXD motif; other site
498216001843	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
498216001844	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
498216001845	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
498216001846	Predicted membrane protein [Function unknown]; Region: COG2246
498216001847	GtrA-like protein; Region: GtrA; pfam04138
498216001848	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
498216001849	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
498216001850	active site
498216001851	phosphorylation site [posttranslational modification]
498216001852	intermolecular recognition site; other site
498216001853	dimerization interface [polypeptide binding]; other site
498216001854	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
498216001855	DNA binding site [nucleotide binding]
498216001856	Di-sulfide bridge nucleocytoplasmic transport domain; Region: Brr6_like_C_C; cl12377
498216001857	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
498216001858	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
498216001859	dimer interface [polypeptide binding]; other site
498216001860	phosphorylation site [posttranslational modification]
498216001861	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
498216001862	ATP binding site [chemical binding]; other site
498216001863	Mg2+ binding site [ion binding]; other site
498216001864	G-X-G motif; other site
498216001865	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4918
498216001866	hypothetical protein; Provisional; Region: PRK06194
498216001867	classical (c) SDRs; Region: SDR_c; cd05233
498216001868	NAD(P) binding site [chemical binding]; other site
498216001869	active site
498216001870	Acetoacetate decarboxylase (ADC); Region: ADC; pfam06314
498216001871	Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137
498216001872	dimer interface [polypeptide binding]; other site
498216001873	FMN binding site [chemical binding]; other site
498216001874	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
498216001875	FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070
498216001876	phosphate binding site [ion binding]; other site
498216001877	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
498216001878	Homeodomain-like domain; Region: HTH_23; pfam13384
498216001879	Transposase; Region: DDE_Tnp_ISL3; pfam01610
498216001880	Predicted transcriptional regulators [Transcription]; Region: COG1695
498216001881	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
498216001882	Sugar efflux transporter for intercellular exchange; Region: MtN3_slv; pfam03083
498216001883	zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817
498216001884	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
498216001885	NAD(P) binding site [chemical binding]; other site
498216001886	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
498216001887	Domain of unknown function DUF20; Region: UPF0118; pfam01594
498216001888	LexA repressor; Validated; Region: PRK00215
498216001889	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
498216001890	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
498216001891	Catalytic site [active]
498216001892	Membrane transport protein; Region: Mem_trans; pfam03547
498216001893	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
498216001894	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
498216001895	Uncharacterized conserved protein [Function unknown]; Region: COG3189
498216001896	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
498216001897	uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827
498216001898	Cl binding site [ion binding]; other site
498216001899	oligomer interface [polypeptide binding]; other site
498216001900	Transcriptional regulator [Transcription]; Region: LysR; COG0583
498216001901	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
498216001902	The substrate binding domain of LysR-type transcriptional regulator MleR which required for malolactic fermentation, contains type 2 periplasmic binidning fold; Region: PBP2_MleR; cd08437
498216001903	putative dimerization interface [polypeptide binding]; other site
498216001904	malate dehydrogenase; Provisional; Region: PRK13529
498216001905	Malic enzyme, N-terminal domain; Region: malic; pfam00390
498216001906	NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312
498216001907	NAD(P) binding site [chemical binding]; other site
498216001908	Membrane transport protein; Region: Mem_trans; pfam03547
498216001909	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
498216001910	dimer interface [polypeptide binding]; other site
498216001911	catalytic triad [active]
498216001912	peroxidatic and resolving cysteines [active]
498216001913	Flavodoxin domain; Region: Flavodoxin_5; cl17428
498216001914	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
498216001915	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
498216001916	non-specific DNA binding site [nucleotide binding]; other site
498216001917	salt bridge; other site
498216001918	sequence-specific DNA binding site [nucleotide binding]; other site
498216001919	transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716
498216001920	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
498216001921	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
498216001922	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
498216001923	Walker A/P-loop; other site
498216001924	ATP binding site [chemical binding]; other site
498216001925	Q-loop/lid; other site
498216001926	ABC transporter signature motif; other site
498216001927	Walker B; other site
498216001928	D-loop; other site
498216001929	H-loop/switch region; other site
498216001930	oligoendopeptidase F; Region: pepF; TIGR00181
498216001931	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_4; cd09609
498216001932	active site
498216001933	Zn binding site [ion binding]; other site
498216001934	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
498216001935	glucose-1-dehydrogenase; Provisional; Region: PRK06947
498216001936	NAD(P) binding site [chemical binding]; other site
498216001937	active site
498216001938	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
498216001939	active site
498216001940	multimer interface [polypeptide binding]; other site
498216001941	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
498216001942	ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494
498216001943	Soluble P-type ATPase [General function prediction only]; Region: COG4087
498216001944	proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250
498216001945	Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523
498216001946	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
498216001947	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
498216001948	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
498216001949	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
498216001950	motif II; other site
498216001951	Transcriptional regulators [Transcription]; Region: MarR; COG1846
498216001952	MarR family; Region: MarR_2; pfam12802
498216001953	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
498216001954	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
498216001955	flavoprotein NrdI; Provisional; Region: PRK02551
498216001956	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
498216001957	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
498216001958	active site
498216001959	catalytic tetrad [active]
498216001960	Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028
498216001961	Predicted membrane protein [Function unknown]; Region: COG2323
498216001962	Protein of unknown function (DUF3290); Region: DUF3290; pfam11694
498216001963	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
498216001964	substrate binding site [chemical binding]; other site
498216001965	THF binding site; other site
498216001966	zinc-binding site [ion binding]; other site
498216001967	S-ribosylhomocysteinase; Provisional; Region: PRK02260
498216001968	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
498216001969	Homeodomain-like domain; Region: HTH_23; pfam13384
498216001970	Transposase; Region: DDE_Tnp_ISL3; pfam01610
498216001971	Uncharacterized conserved protein [Function unknown]; Region: COG0398
498216001972	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
498216001973	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
498216001974	RuvA N terminal domain; Region: RuvA_N; pfam01330
498216001975	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
498216001976	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
498216001977	Walker A motif; other site
498216001978	ATP binding site [chemical binding]; other site
498216001979	Walker B motif; other site
498216001980	arginine finger; other site
498216001981	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
498216001982	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
498216001983	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
498216001984	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
498216001985	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
498216001986	Preprotein translocase subunit; Region: YajC; pfam02699
498216001987	bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805
498216001988	Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122
498216001989	putative catalytic cysteine [active]
498216001990	C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178
498216001991	putative active site [active]
498216001992	metal binding site [ion binding]; metal-binding site
498216001993	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
498216001994	Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529
498216001995	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
498216001996	FeoA domain; Region: FeoA; pfam04023
498216001997	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
498216001998	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
498216001999	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
498216002000	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
498216002001	active site
498216002002	DNA polymerase IV; Validated; Region: PRK02406
498216002003	DNA binding site [nucleotide binding]
498216002004	Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109
498216002005	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
498216002006	DNA-binding site [nucleotide binding]; DNA binding site
498216002007	DRTGG domain; Region: DRTGG; pfam07085
498216002008	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
498216002009	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
498216002010	DHH family; Region: DHH; pfam01368
498216002011	ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192
498216002012	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
498216002013	ATP binding site [chemical binding]; other site
498216002014	Mg++ binding site [ion binding]; other site
498216002015	motif III; other site
498216002016	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
498216002017	nucleotide binding region [chemical binding]; other site
498216002018	ATP-binding site [chemical binding]; other site
498216002019	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
498216002020	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
498216002021	motif 1; other site
498216002022	active site
498216002023	motif 2; other site
498216002024	motif 3; other site
498216002025	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
498216002026	DHHA1 domain; Region: DHHA1; pfam02272
498216002027	Protein of unknown function (DUF1343); Region: DUF1343; cl01598
498216002028	hypothetical protein; Provisional; Region: PRK05473
498216002029	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
498216002030	hypothetical protein; Provisional; Region: PRK13678
498216002031	Cell division protein ZapA; Region: ZapA; pfam05164
498216002032	Colicin V production protein; Region: Colicin_V; pfam02674
498216002033	recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409
498216002034	MutS domain III; Region: MutS_III; pfam05192
498216002035	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
498216002036	Walker A/P-loop; other site
498216002037	ATP binding site [chemical binding]; other site
498216002038	Q-loop/lid; other site
498216002039	ABC transporter signature motif; other site
498216002040	Walker B; other site
498216002041	D-loop; other site
498216002042	H-loop/switch region; other site
498216002043	V-type ATP synthase subunit H; Validated; Region: PRK06397
498216002044	Smr domain; Region: Smr; pfam01713
498216002045	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
498216002046	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
498216002047	catalytic residues [active]
498216002048	D-alanine--poly(phosphoribitol) ligase, subunit 1; Region: D-ala-DACP-lig; TIGR01734
498216002049	D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945
498216002050	acyl-activating enzyme (AAE) consensus motif; other site
498216002051	AMP binding site [chemical binding]; other site
498216002052	D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091
498216002053	D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087
498216002054	D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092
498216002055	DltD N-terminal region; Region: DltD_N; pfam04915
498216002056	DltD central region; Region: DltD_M; pfam04918
498216002057	DltD C-terminal region; Region: DltD_C; pfam04914
498216002058	Protein of unknown function (DUF2507); Region: DUF2507; pfam10702
498216002059	glutamate racemase; Provisional; Region: PRK00865
498216002060	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
498216002061	active site
498216002062	dimerization interface [polypeptide binding]; other site
498216002063	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
498216002064	active site
498216002065	metal binding site [ion binding]; metal-binding site
498216002066	homotetramer interface [polypeptide binding]; other site
498216002067	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
498216002068	amphipathic channel; other site
498216002069	Asn-Pro-Ala signature motifs; other site
498216002070	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643
498216002071	FOG: CBS domain [General function prediction only]; Region: COG0517
498216002072	Domain of unknown function (DUF368); Region: DUF368; pfam04018
498216002073	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
498216002074	Mechanosensitive ion channel; Region: MS_channel; pfam00924
498216002075	Bacterial protein of unknown function (DUF948); Region: DUF948; pfam06103
498216002076	YtxH-like protein; Region: YtxH; pfam12732
498216002077	Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827
498216002078	HTH domain; Region: HTH_11; pfam08279
498216002079	3H domain; Region: 3H; pfam02829
498216002080	catabolite control protein A; Region: ccpA; TIGR01481
498216002081	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
498216002082	DNA binding site [nucleotide binding]
498216002083	domain linker motif; other site
498216002084	Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298
498216002085	dimerization interface [polypeptide binding]; other site
498216002086	effector binding site; other site
498216002087	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
498216002088	Transglycosylase; Region: Transgly; pfam00912
498216002089	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
498216002090	HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB
498216002091	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
498216002092	motif II; other site
498216002093	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
498216002094	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
498216002095	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
498216002096	dipeptidase PepV; Reviewed; Region: PRK07318
498216002097	M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888
498216002098	active site
498216002099	metal binding site [ion binding]; metal-binding site
498216002100	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
498216002101	Glycerophosphodiester phosphodiesterase domain as found in prokaryota and eukaryota, and similar proteins; Region: GDPD; cd08556
498216002102	active site
498216002103	catalytic site [active]
498216002104	metal binding site [ion binding]; metal-binding site
498216002105	YibE/F-like protein; Region: YibE_F; pfam07907
498216002106	YibE/F-like protein; Region: YibE_F; pfam07907
498216002107	Aquifex aeolicus AQ1575 and related proteins, metallophosphatase domain; Region: MPP_AQ1575; cd07390
498216002108	putative active site [active]
498216002109	putative metal binding site [ion binding]; other site
498216002110	Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845
498216002111	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
498216002112	active site
498216002113	metal binding site [ion binding]; metal-binding site
498216002114	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
498216002115	Protein of unknown function (DUF1027); Region: DUF1027; pfam06265
498216002116	HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2
498216002117	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
498216002118	active site
498216002119	motif I; other site
498216002120	motif II; other site
498216002121	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
498216002122	Protein of unknown function (DUF1461); Region: DUF1461; pfam07314
498216002123	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
498216002124	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
498216002125	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
498216002126	tetramer interfaces [polypeptide binding]; other site
498216002127	binuclear metal-binding site [ion binding]; other site
498216002128	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
498216002129	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
498216002130	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
498216002131	Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family [Posttranslational modification, protein turnover, chaperones]; Region: PpiB; COG0652
498216002132	active site
498216002133	general stress protein 13; Validated; Region: PRK08059
498216002134	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692
498216002135	RNA binding site [nucleotide binding]; other site
498216002136	RNA polymerase sigma-70 factor, Planctomycetaceae-specific subfamily 1; Region: Sig-70_plancto1; TIGR02984
498216002137	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
498216002138	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
498216002139	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
498216002140	This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817
498216002141	putative ADP-binding pocket [chemical binding]; other site
498216002142	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
498216002143	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
498216002144	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
498216002145	Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706
498216002146	aromatic amino acid aminotransferase; Validated; Region: PRK07309
498216002147	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
498216002148	pyridoxal 5'-phosphate binding site [chemical binding]; other site
498216002149	homodimer interface [polypeptide binding]; other site
498216002150	catalytic residue [active]
498216002151	Protein of unknown function (DUF1797); Region: DUF1797; pfam08796
498216002152	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
498216002153	metal binding site 2 [ion binding]; metal-binding site
498216002154	putative DNA binding helix; other site
498216002155	metal binding site 1 [ion binding]; metal-binding site
498216002156	dimer interface [polypeptide binding]; other site
498216002157	structural Zn2+ binding site [ion binding]; other site
498216002158	S-adenosylmethionine synthetase; Validated; Region: PRK05250
498216002159	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
498216002160	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
498216002161	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
498216002162	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
498216002163	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
498216002164	putative substrate translocation pore; other site
498216002165	Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105
498216002166	DNA binding residues [nucleotide binding]
498216002167	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
498216002168	putative dimer interface [polypeptide binding]; other site
498216002169	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
498216002170	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
498216002171	putative substrate translocation pore; other site
498216002172	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
498216002173	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
498216002174	active site
498216002175	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
498216002176	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
498216002177	HIGH motif; other site
498216002178	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
498216002179	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
498216002180	active site
498216002181	KMSKS motif; other site
498216002182	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
498216002183	tRNA binding surface [nucleotide binding]; other site
498216002184	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
498216002185	Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124
498216002186	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
498216002187	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
498216002188	RNA binding surface [nucleotide binding]; other site
498216002189	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
498216002190	active site
498216002191	uracil binding [chemical binding]; other site
498216002192	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082); Region: DUF2082; pfam09855
498216002193	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
498216002194	putative substrate binding site [chemical binding]; other site
498216002195	putative ATP binding site [chemical binding]; other site
498216002196	Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684
498216002197	nudix motif; other site
498216002198	Domain of unknown function (DUF1975); Region: DUF1975; pfam09318
498216002199	This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding.  In...; Region: GT1_gtfA_like; cd04949
498216002200	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
498216002201	Domain of unknown function (DUF1975); Region: DUF1975; pfam09318
498216002202	This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding.  In...; Region: GT1_gtfA_like; cd04949
498216002203	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
498216002204	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
498216002205	catalytic residues [active]
498216002206	dimer interface [polypeptide binding]; other site
498216002207	Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168
498216002208	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
498216002209	pyridoxal 5'-phosphate binding site [chemical binding]; other site
498216002210	homodimer interface [polypeptide binding]; other site
498216002211	catalytic residue [active]
498216002212	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
498216002213	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
498216002214	active site
498216002215	metal binding site [ion binding]; metal-binding site
498216002216	ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872
498216002217	Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025
498216002218	Competence protein CoiA-like family; Region: CoiA; cl11541
498216002219	Thioredoxin; Region: Thioredoxin_5; pfam13743
498216002220	Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762
498216002221	putative active site [active]
498216002222	putative metal binding residues [ion binding]; other site
498216002223	signature motif; other site
498216002224	putative triphosphate binding site [ion binding]; other site
498216002225	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
498216002226	synthetase active site [active]
498216002227	NTP binding site [chemical binding]; other site
498216002228	metal binding site [ion binding]; metal-binding site
498216002229	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885
498216002230	ATP-NAD kinase; Region: NAD_kinase; pfam01513
498216002231	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
498216002232	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
498216002233	RNA binding surface [nucleotide binding]; other site
498216002234	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
498216002235	active site
498216002236	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
498216002237	ApbE family; Region: ApbE; pfam02424
498216002238	Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142
498216002239	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
498216002240	Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282
498216002241	PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; pfam03829
498216002242	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
498216002243	guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458
498216002244	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
498216002245	active site
498216002246	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
498216002247	uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827
498216002248	Cl binding site [ion binding]; other site
498216002249	oligomer interface [polypeptide binding]; other site
498216002250	23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088
498216002251	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
498216002252	S-adenosylmethionine binding site [chemical binding]; other site
498216002253	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
498216002254	Protein of unknown function (DUF1149); Region: DUF1149; pfam06619
498216002255	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
498216002256	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
498216002257	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
498216002258	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
498216002259	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
498216002260	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
498216002261	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
498216002262	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
498216002263	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
498216002264	classical (c) SDRs; Region: SDR_c; cd05233
498216002265	NAD(P) binding site [chemical binding]; other site
498216002266	active site
498216002267	Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426
498216002268	Helix-turn-helix domain; Region: HTH_25; pfam13413
498216002269	non-specific DNA binding site [nucleotide binding]; other site
498216002270	salt bridge; other site
498216002271	sequence-specific DNA binding site [nucleotide binding]; other site
498216002272	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
498216002273	CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Region: pgsA; TIGR00560
498216002274	competence damage-inducible protein A; Provisional; Region: PRK00549
498216002275	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
498216002276	putative MPT binding site; other site
498216002277	Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546
498216002278	recombinase A; Provisional; Region: recA; PRK09354
498216002279	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
498216002280	hexamer interface [polypeptide binding]; other site
498216002281	Walker A motif; other site
498216002282	ATP binding site [chemical binding]; other site
498216002283	Walker B motif; other site
498216002284	ribonuclease Y; Region: RNase_Y; TIGR03319
498216002285	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
498216002286	Zn2+ binding site [ion binding]; other site
498216002287	Mg2+ binding site [ion binding]; other site
498216002288	Uncharacterized conserved protein [Function unknown]; Region: COG1739
498216002289	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
498216002290	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
498216002291	Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098
498216002292	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
498216002293	ATP binding site [chemical binding]; other site
498216002294	putative Mg++ binding site [ion binding]; other site
498216002295	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
498216002296	nucleotide binding region [chemical binding]; other site
498216002297	ATP-binding site [chemical binding]; other site
498216002298	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
498216002299	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
498216002300	active site
498216002301	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
498216002302	30S subunit binding site; other site
498216002303	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
498216002304	Transposase; Region: DDE_Tnp_ISL3; pfam01610
498216002305	preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12906
498216002306	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
498216002307	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
498216002308	nucleotide binding region [chemical binding]; other site
498216002309	ATP-binding site [chemical binding]; other site
498216002310	peptide chain release factor 2; Validated; Region: prfB; PRK00578
498216002311	Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; Region: SPEC; cl02488
498216002312	PCRF domain; Region: PCRF; pfam03462
498216002313	RF-1 domain; Region: RF-1; pfam00472
498216002314	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
498216002315	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
498216002316	Walker A/P-loop; other site
498216002317	ATP binding site [chemical binding]; other site
498216002318	Q-loop/lid; other site
498216002319	ABC transporter signature motif; other site
498216002320	Walker B; other site
498216002321	D-loop; other site
498216002322	H-loop/switch region; other site
498216002323	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
498216002324	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
498216002325	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
498216002326	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
498216002327	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
498216002328	active site
498216002329	phosphorylation site [posttranslational modification]
498216002330	intermolecular recognition site; other site
498216002331	dimerization interface [polypeptide binding]; other site
498216002332	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
498216002333	DNA binding site [nucleotide binding]
498216002334	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
498216002335	PAS domain; Region: PAS_8; pfam13188
498216002336	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
498216002337	dimer interface [polypeptide binding]; other site
498216002338	phosphorylation site [posttranslational modification]
498216002339	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
498216002340	ATP binding site [chemical binding]; other site
498216002341	Mg2+ binding site [ion binding]; other site
498216002342	G-X-G motif; other site
498216002343	phosphate binding protein; Region: ptsS_2; TIGR02136
498216002344	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
498216002345	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
498216002346	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
498216002347	dimer interface [polypeptide binding]; other site
498216002348	conserved gate region; other site
498216002349	putative PBP binding loops; other site
498216002350	ABC-ATPase subunit interface; other site
498216002351	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
498216002352	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
498216002353	dimer interface [polypeptide binding]; other site
498216002354	conserved gate region; other site
498216002355	putative PBP binding loops; other site
498216002356	ABC-ATPase subunit interface; other site
498216002357	phosphate transporter ATP-binding protein; Provisional; Region: PRK14237
498216002358	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
498216002359	Walker A/P-loop; other site
498216002360	ATP binding site [chemical binding]; other site
498216002361	Q-loop/lid; other site
498216002362	ABC transporter signature motif; other site
498216002363	Walker B; other site
498216002364	D-loop; other site
498216002365	H-loop/switch region; other site
498216002366	phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14255
498216002367	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
498216002368	Walker A/P-loop; other site
498216002369	ATP binding site [chemical binding]; other site
498216002370	Q-loop/lid; other site
498216002371	ABC transporter signature motif; other site
498216002372	Walker B; other site
498216002373	D-loop; other site
498216002374	H-loop/switch region; other site
498216002375	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
498216002376	PhoU domain; Region: PhoU; pfam01895
498216002377	PhoU domain; Region: PhoU; pfam01895
498216002378	Uncharacterized conserved protein [Function unknown]; Region: COG3595
498216002379	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
498216002380	Membrane protein of unknown function; Region: DUF360; pfam04020
498216002381	HPr kinase/phosphorylase; Provisional; Region: PRK05428
498216002382	HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603
498216002383	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918
498216002384	Hpr binding site; other site
498216002385	active site
498216002386	homohexamer subunit interaction site [polypeptide binding]; other site
498216002387	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437
498216002388	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
498216002389	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
498216002390	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
498216002391	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
498216002392	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
498216002393	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
498216002394	phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150
498216002395	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
498216002396	active site
498216002397	substrate binding site [chemical binding]; other site
498216002398	metal binding site [ion binding]; metal-binding site
498216002399	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
498216002400	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
498216002401	active site
498216002402	phosphorylation site [posttranslational modification]
498216002403	intermolecular recognition site; other site
498216002404	dimerization interface [polypeptide binding]; other site
498216002405	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
498216002406	DNA binding site [nucleotide binding]
498216002407	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
498216002408	His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388
498216002409	dimer interface [polypeptide binding]; other site
498216002410	phosphorylation site [posttranslational modification]
498216002411	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
498216002412	ATP binding site [chemical binding]; other site
498216002413	Mg2+ binding site [ion binding]; other site
498216002414	G-X-G motif; other site
498216002415	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
498216002416	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
498216002417	Walker A/P-loop; other site
498216002418	ATP binding site [chemical binding]; other site
498216002419	Q-loop/lid; other site
498216002420	ABC transporter signature motif; other site
498216002421	Walker B; other site
498216002422	D-loop; other site
498216002423	H-loop/switch region; other site
498216002424	FtsX-like permease family; Region: FtsX; pfam02687
498216002425	HD domain; Region: HD_3; cl17350
498216002426	excinuclease ABC subunit B; Provisional; Region: PRK05298
498216002427	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
498216002428	ATP binding site [chemical binding]; other site
498216002429	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
498216002430	nucleotide binding region [chemical binding]; other site
498216002431	ATP-binding site [chemical binding]; other site
498216002432	Ultra-violet resistance protein B; Region: UvrB; pfam12344
498216002433	UvrB/uvrC motif; Region: UVR; pfam02151
498216002434	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
498216002435	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
498216002436	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
498216002437	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
498216002438	Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247
498216002439	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
498216002440	conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826
498216002441	family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187
498216002442	phosphate binding site [ion binding]; other site
498216002443	putative substrate binding pocket [chemical binding]; other site
498216002444	dimer interface [polypeptide binding]; other site
498216002445	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481
498216002446	Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298
498216002447	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
498216002448	MarR family; Region: MarR; pfam01047
498216002449	Clp protease; Region: CLP_protease; pfam00574
498216002450	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
498216002451	oligomer interface [polypeptide binding]; other site
498216002452	active site residues [active]
498216002453	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
498216002454	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
498216002455	glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534
498216002456	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
498216002457	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
498216002458	Phosphoglycerate kinase; Region: PGK; pfam00162
498216002459	substrate binding site [chemical binding]; other site
498216002460	hinge regions; other site
498216002461	ADP binding site [chemical binding]; other site
498216002462	catalytic site [active]
498216002463	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
498216002464	triosephosphate isomerase; Provisional; Region: PRK14567
498216002465	substrate binding site [chemical binding]; other site
498216002466	dimer interface [polypeptide binding]; other site
498216002467	catalytic triad [active]
498216002468	enolase; Provisional; Region: eno; PRK00077
498216002469	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
498216002470	dimer interface [polypeptide binding]; other site
498216002471	metal binding site [ion binding]; metal-binding site
498216002472	substrate binding pocket [chemical binding]; other site
498216002473	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
498216002474	H+ Antiporter protein; Region: 2A0121; TIGR00900
498216002475	putative substrate translocation pore; other site
498216002476	ClC chloride channel EriC.  This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031
498216002477	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
498216002478	Cl- selectivity filter; other site
498216002479	Cl- binding residues [ion binding]; other site
498216002480	pore gating glutamate residue; other site
498216002481	dimer interface [polypeptide binding]; other site
498216002482	H+/Cl- coupling transport residue; other site
498216002483	TrkA-C domain; Region: TrkA_C; pfam02080
498216002484	preprotein translocase subunit SecG; Reviewed; Region: secG; PRK06870
498216002485	Esterase/lipase [General function prediction only]; Region: COG1647
498216002486	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
498216002487	ribonuclease R; Region: RNase_R; TIGR02063
498216002488	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
498216002489	RNB domain; Region: RNB; pfam00773
498216002490	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
498216002491	RNA binding site [nucleotide binding]; other site
498216002492	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
498216002493	SmpB-tmRNA interface; other site
498216002494	Transcriptional regulators [Transcription]; Region: PurR; COG1609
498216002495	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
498216002496	DNA binding site [nucleotide binding]
498216002497	domain linker motif; other site
498216002498	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
498216002499	ligand binding site [chemical binding]; other site
498216002500	dimerization interface [polypeptide binding]; other site
498216002501	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
498216002502	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
498216002503	Ca binding site [ion binding]; other site
498216002504	active site
498216002505	catalytic site [active]
498216002506	N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857
498216002507	homodimer interface [polypeptide binding]; other site
498216002508	Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338
498216002509	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
498216002510	active site
498216002511	homodimer interface [polypeptide binding]; other site
498216002512	catalytic site [active]
498216002513	maltose phosphorylase; Provisional; Region: PRK13807
498216002514	Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636
498216002515	Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632
498216002516	Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633
498216002517	beta-phosphoglucomutase; Region: bPGM; TIGR01990
498216002518	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
498216002519	motif II; other site
498216002520	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
498216002521	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
498216002522	Walker A/P-loop; other site
498216002523	ATP binding site [chemical binding]; other site
498216002524	Q-loop/lid; other site
498216002525	ABC transporter signature motif; other site
498216002526	Walker B; other site
498216002527	D-loop; other site
498216002528	H-loop/switch region; other site
498216002529	TOBE domain; Region: TOBE_2; pfam08402
498216002530	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
498216002531	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
498216002532	Ca binding site [ion binding]; other site
498216002533	active site
498216002534	catalytic site [active]
498216002535	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
498216002536	Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182
498216002537	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
498216002538	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
498216002539	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
498216002540	dimer interface [polypeptide binding]; other site
498216002541	conserved gate region; other site
498216002542	ABC-ATPase subunit interface; other site
498216002543	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
498216002544	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
498216002545	non-specific DNA binding site [nucleotide binding]; other site
498216002546	salt bridge; other site
498216002547	sequence-specific DNA binding site [nucleotide binding]; other site
498216002548	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
498216002549	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
498216002550	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
498216002551	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
498216002552	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
498216002553	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
498216002554	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
498216002555	dimer interface [polypeptide binding]; other site
498216002556	conserved gate region; other site
498216002557	putative PBP binding loops; other site
498216002558	ABC-ATPase subunit interface; other site
498216002559	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
498216002560	dimer interface [polypeptide binding]; other site
498216002561	conserved gate region; other site
498216002562	putative PBP binding loops; other site
498216002563	ABC-ATPase subunit interface; other site
498216002564	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
498216002565	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
498216002566	Walker A/P-loop; other site
498216002567	ATP binding site [chemical binding]; other site
498216002568	Q-loop/lid; other site
498216002569	ABC transporter signature motif; other site
498216002570	Walker B; other site
498216002571	D-loop; other site
498216002572	H-loop/switch region; other site
498216002573	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
498216002574	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
498216002575	Coenzyme A binding pocket [chemical binding]; other site
498216002576	Tubby C 2; Region: Tub_2; cl02043
498216002577	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
498216002578	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
498216002579	active site
498216002580	motif I; other site
498216002581	motif II; other site
498216002582	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
498216002583	ligand binding site [chemical binding]; other site
498216002584	active site
498216002585	UGI interface [polypeptide binding]; other site
498216002586	catalytic site [active]
498216002587	phosphotransacetylase; Reviewed; Region: eutD; PRK09653
498216002588	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
498216002589	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
498216002590	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
498216002591	non-specific DNA binding site [nucleotide binding]; other site
498216002592	salt bridge; other site
498216002593	sequence-specific DNA binding site [nucleotide binding]; other site
498216002594	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152
498216002595	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
498216002596	Walker A/P-loop; other site
498216002597	ATP binding site [chemical binding]; other site
498216002598	Q-loop/lid; other site
498216002599	ABC transporter signature motif; other site
498216002600	Walker B; other site
498216002601	D-loop; other site
498216002602	H-loop/switch region; other site
498216002603	Domain of unknown function (DUF4162); Region: DUF4162; pfam13732
498216002604	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
498216002605	an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130
498216002606	active site
498216002607	catalytic site [active]
498216002608	substrate binding site [chemical binding]; other site
498216002609	Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087
498216002610	active site
498216002611	putative catalytic site [active]
498216002612	DNA binding site [nucleotide binding]
498216002613	putative phosphate binding site [ion binding]; other site
498216002614	metal binding site A [ion binding]; metal-binding site
498216002615	AP binding site [nucleotide binding]; other site
498216002616	metal binding site B [ion binding]; metal-binding site
498216002617	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
498216002618	FAD binding domain; Region: FAD_binding_4; pfam01565
498216002619	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
498216002620	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
498216002621	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
498216002622	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
498216002623	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
498216002624	non-specific DNA binding site [nucleotide binding]; other site
498216002625	salt bridge; other site
498216002626	sequence-specific DNA binding site [nucleotide binding]; other site
498216002627	Cupin domain; Region: Cupin_2; pfam07883
498216002628	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
498216002629	ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300
498216002630	Walker A/P-loop; other site
498216002631	ATP binding site [chemical binding]; other site
498216002632	Q-loop/lid; other site
498216002633	ABC transporter signature motif; other site
498216002634	Walker B; other site
498216002635	D-loop; other site
498216002636	H-loop/switch region; other site
498216002637	TOBE domain; Region: TOBE_2; pfam08402
498216002638	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
498216002639	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
498216002640	dimer interface [polypeptide binding]; other site
498216002641	conserved gate region; other site
498216002642	putative PBP binding loops; other site
498216002643	ABC-ATPase subunit interface; other site
498216002644	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
498216002645	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
498216002646	dimer interface [polypeptide binding]; other site
498216002647	conserved gate region; other site
498216002648	putative PBP binding loops; other site
498216002649	ABC-ATPase subunit interface; other site
498216002650	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
498216002651	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
498216002652	Helix-turn-helix domain; Region: HTH_28; pfam13518
498216002653	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
498216002654	Transposase; Region: HTH_Tnp_1; pfam01527
498216002655	Helix-turn-helix domain; Region: HTH_28; pfam13518
498216002656	HTH-like domain; Region: HTH_21; pfam13276
498216002657	Integrase core domain; Region: rve; pfam00665
498216002658	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
498216002659	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
498216002660	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
498216002661	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
498216002662	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
498216002663	motif II; other site
498216002664	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
498216002665	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
498216002666	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
498216002667	PXA domain; Region: PXA; cl02564
498216002668	ABC-2 type transporter; Region: ABC2_membrane; cl17235
498216002669	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
498216002670	ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864
498216002671	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
498216002672	Walker A/P-loop; other site
498216002673	ATP binding site [chemical binding]; other site
498216002674	Q-loop/lid; other site
498216002675	ABC transporter signature motif; other site
498216002676	Walker B; other site
498216002677	D-loop; other site
498216002678	H-loop/switch region; other site
498216002679	Uncharacterized conserved protein [Function unknown]; Region: COG1624
498216002680	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
498216002681	YbbR-like protein; Region: YbbR; pfam07949
498216002682	YbbR-like protein; Region: YbbR; pfam07949
498216002683	YbbR-like protein; Region: YbbR; pfam07949
498216002684	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316
498216002685	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
498216002686	active site
498216002687	substrate binding site [chemical binding]; other site
498216002688	metal binding site [ion binding]; metal-binding site
498216002689	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
498216002690	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
498216002691	glutaminase active site [active]
498216002692	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
498216002693	dimer interface [polypeptide binding]; other site
498216002694	active site
498216002695	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
498216002696	dimer interface [polypeptide binding]; other site
498216002697	active site
498216002698	oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290
498216002699	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_2; cd09607
498216002700	active site
498216002701	Zn binding site [ion binding]; other site
498216002702	hypothetical protein; Validated; Region: PRK00110
498216002703	Type II/IV secretion system protein; Region: T2SE; pfam00437
498216002704	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
498216002705	Walker A motif; other site
498216002706	ATP binding site [chemical binding]; other site
498216002707	Walker B motif; other site
498216002708	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
498216002709	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
498216002710	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830
498216002711	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899
498216002712	Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827
498216002713	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
498216002714	S-adenosylmethionine binding site [chemical binding]; other site
498216002715	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
498216002716	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
498216002717	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185
498216002718	putative acyl-acceptor binding pocket; other site
498216002719	A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194
498216002720	Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501
498216002721	Ligand binding site; other site
498216002722	metal-binding site
498216002723	A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194
498216002724	Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501
498216002725	Ligand binding site; other site
498216002726	metal-binding site
498216002727	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
498216002728	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
498216002729	putative acyl-acceptor binding pocket; other site
498216002730	Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345
498216002731	Melibiase; Region: Melibiase; pfam02065
498216002732	5'-3' exonuclease, N-terminal resolvase-like domain; Region: 5_3_exonuc_N; pfam02739
498216002733	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
498216002734	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
498216002735	Int/Topo IB signature motif; other site
498216002736	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
498216002737	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
498216002738	non-specific DNA binding site [nucleotide binding]; other site
498216002739	salt bridge; other site
498216002740	sequence-specific DNA binding site [nucleotide binding]; other site
498216002741	Helix-turn-helix domain; Region: HTH_17; pfam12728
498216002742	Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859
498216002743	polymerase nucleotide-binding site; other site
498216002744	DNA-binding residues [nucleotide binding]; DNA binding site
498216002745	nucleotide binding site [chemical binding]; other site
498216002746	primase nucleotide-binding site [nucleotide binding]; other site
498216002747	Primase C terminal 1 (PriCT-1); Region: PriCT_1; smart00942
498216002748	Predicted P-loop ATPase and inactivated derivatives [General function prediction only]; Region: COG5545
498216002749	Virulence-associated protein E; Region: VirE; pfam05272
498216002750	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
498216002751	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
498216002752	active site
498216002753	Phage terminase, small subunit; Region: Terminase_4; pfam05119
498216002754	Phage Terminase; Region: Terminase_1; pfam03354
498216002755	Phage portal protein; Region: Phage_portal; pfam04860
498216002756	Phage-related protein [Function unknown]; Region: COG4695; cl01923
498216002757	Caudovirus prohead protease; Region: Peptidase_U35; pfam04586
498216002758	phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554
498216002759	Phage capsid family; Region: Phage_capsid; pfam05065
498216002760	Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054
498216002761	oligomerization interface [polypeptide binding]; other site
498216002762	Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521
498216002763	Predicted membrane protein [Function unknown]; Region: COG2261
498216002764	SdpI/YhfL protein family; Region: SdpI; pfam13630
498216002765	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
498216002766	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
498216002767	active site
498216002768	phosphorylation site [posttranslational modification]
498216002769	intermolecular recognition site; other site
498216002770	dimerization interface [polypeptide binding]; other site
498216002771	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
498216002772	DNA binding site [nucleotide binding]
498216002773	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
498216002774	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
498216002775	dimerization interface [polypeptide binding]; other site
498216002776	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
498216002777	dimer interface [polypeptide binding]; other site
498216002778	phosphorylation site [posttranslational modification]
498216002779	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
498216002780	ATP binding site [chemical binding]; other site
498216002781	Mg2+ binding site [ion binding]; other site
498216002782	G-X-G motif; other site
498216002783	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
498216002784	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
498216002785	Coenzyme A binding pocket [chemical binding]; other site
498216002786	hypothetical protein; Provisional; Region: PRK04435
498216002787	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393
498216002788	DNA-binding interface [nucleotide binding]; DNA binding site
498216002789	C-terminal ACT domain of a small (; 147 a.a.) putative phenylalanine biosynthetic pathway protein described in Bacillus subtilis (BS) PheB (PheB-BS) and related domains; Region: ACT_PheB-BS; cd04888
498216002790	DNA polymerase IV; Reviewed; Region: PRK03103
498216002791	umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700
498216002792	active site
498216002793	DNA binding site [nucleotide binding]
498216002794	Domain of unknown function (DUF4113); Region: DUF4113; pfam13438
498216002795	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
498216002796	Double zinc ribbon; Region: DZR; pfam12773
498216002797	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
498216002798	active site
498216002799	catalytic triad [active]
498216002800	oxyanion hole [active]
498216002801	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
498216002802	Part of AAA domain; Region: AAA_19; pfam13245
498216002803	Family description; Region: UvrD_C_2; pfam13538
498216002804	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
498216002805	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
498216002806	nucleotide binding pocket [chemical binding]; other site
498216002807	K-X-D-G motif; other site
498216002808	catalytic site [active]
498216002809	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
498216002810	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
498216002811	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
498216002812	Dimer interface [polypeptide binding]; other site
498216002813	BRCT sequence motif; other site
498216002814	N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441
498216002815	putative dimer interface [polypeptide binding]; other site
498216002816	CamS sex pheromone cAM373 precursor; Region: CamS; pfam07537
498216002817	C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440
498216002818	putative dimer interface [polypeptide binding]; other site
498216002819	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
498216002820	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
498216002821	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
498216002822	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
498216002823	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
498216002824	GatB domain; Region: GatB_Yqey; smart00845
498216002825	putative lipid kinase; Reviewed; Region: PRK13055
498216002826	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
498216002827	TRAM domain; Region: TRAM; pfam01938
498216002828	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
498216002829	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
498216002830	S-adenosylmethionine binding site [chemical binding]; other site
498216002831	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
498216002832	Major Facilitator Superfamily; Region: MFS_1; pfam07690
498216002833	putative substrate translocation pore; other site
498216002834	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
498216002835	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
498216002836	active site
498216002837	motif I; other site
498216002838	motif II; other site
498216002839	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
498216002840	polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709
498216002841	Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590
498216002842	Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662
498216002843	active site
498216002844	Zn binding site [ion binding]; other site
498216002845	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
498216002846	Major Facilitator Superfamily; Region: MFS_1; pfam07690
498216002847	putative substrate translocation pore; other site
498216002848	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
498216002849	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
498216002850	Coenzyme A binding pocket [chemical binding]; other site
498216002851	EDD domain protein, DegV family; Region: DegV; TIGR00762
498216002852	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
498216002853	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
498216002854	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
498216002855	Uncharacterized bacterial muramidase containing a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis...; Region: GH25_muramidase_2; cd06419
498216002856	active site
498216002857	Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183
498216002858	Protein of unknown function (DUF1093); Region: DUF1093; pfam06486
498216002859	formate dehydrogenase; Provisional; Region: PRK07574
498216002860	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
498216002861	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
498216002862	ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192
498216002863	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
498216002864	ATP binding site [chemical binding]; other site
498216002865	putative Mg++ binding site [ion binding]; other site
498216002866	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
498216002867	nucleotide binding region [chemical binding]; other site
498216002868	ATP-binding site [chemical binding]; other site
498216002869	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cl00166
498216002870	active site
498216002871	methionine cluster; other site
498216002872	phosphorylation site [posttranslational modification]
498216002873	metal binding site [ion binding]; metal-binding site
498216002874	Domain of unknown function (DUF3284); Region: DUF3284; pfam11687
498216002875	ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389
498216002876	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
498216002877	ATP binding site [chemical binding]; other site
498216002878	putative Mg++ binding site [ion binding]; other site
498216002879	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
498216002880	nucleotide binding region [chemical binding]; other site
498216002881	ATP-binding site [chemical binding]; other site
498216002882	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
498216002883	HRDC domain; Region: HRDC; pfam00570
498216002884	Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073
498216002885	Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309
498216002886	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
498216002887	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
498216002888	WHG domain; Region: WHG; pfam13305
498216002889	Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009
498216002890	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320
498216002891	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
498216002892	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
498216002893	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
498216002894	active site
498216002895	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
498216002896	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
498216002897	active site
498216002898	Protein of unknown function (DUF2922); Region: DUF2922; pfam11148
498216002899	phosphomevalonate kinase, ERG8-type, Gram-positive branch; Region: Pmev_kin_Gr_pos; TIGR01220
498216002900	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
498216002901	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
498216002902	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
498216002903	active site
498216002904	tetramer interface; other site
498216002905	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
498216002906	active site
498216002907	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
498216002908	active site
498216002909	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
498216002910	active site
498216002911	beta-1,6-galactofuranosyltransferase; Provisional; Region: PRK09814
498216002912	beta-1,6-galactofuranosyltransferase; Provisional; Region: PRK09814
498216002913	preprotein translocase subunit SecA; Reviewed; Region: PRK09200
498216002914	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
498216002915	ATP binding site [chemical binding]; other site
498216002916	putative Mg++ binding site [ion binding]; other site
498216002917	SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043
498216002918	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK12417
498216002919	SecY translocase; Region: SecY; pfam00344
498216002920	accessory Sec system protein Asp1; Region: acc_sec_asp1; TIGR03713
498216002921	accessory Sec system protein Asp2; Region: acc_sec_asp2; TIGR03712
498216002922	PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995
498216002923	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
498216002924	active site turn [active]
498216002925	phosphorylation site [posttranslational modification]
498216002926	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
498216002927	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
498216002928	HPr interaction site; other site
498216002929	glycerol kinase (GK) interaction site [polypeptide binding]; other site
498216002930	active site
498216002931	phosphorylation site [posttranslational modification]
498216002932	transcriptional antiterminator BglG; Provisional; Region: PRK09772
498216002933	CAT RNA binding domain; Region: CAT_RBD; smart01061
498216002934	PRD domain; Region: PRD; pfam00874
498216002935	PRD domain; Region: PRD; pfam00874
498216002936	Bacterial membrane protein YfhO; Region: YfhO; pfam09586
498216002937	Bacterial membrane protein YfhO; Region: YfhO; pfam09586
498216002938	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
498216002939	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
498216002940	Ligand binding site; other site
498216002941	Putative Catalytic site; other site
498216002942	DXD motif; other site
498216002943	NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686
498216002944	Predicted membrane protein [Function unknown]; Region: COG4129
498216002945	Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081
498216002946	DUF939 C-terminal domain; Region: DUF939_C; pfam11728
498216002947	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
498216002948	DNA-binding site [nucleotide binding]; DNA binding site
498216002949	RNA-binding motif; other site
498216002950	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
498216002951	Coenzyme A binding pocket [chemical binding]; other site
498216002952	GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718
498216002953	Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705
498216002954	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
498216002955	active site
498216002956	xanthine permease; Region: pbuX; TIGR03173
498216002957	ATP-grasp domain; Region: ATP-grasp_4; cl17255
498216002958	adenylosuccinate lyase; Provisional; Region: PRK07492
498216002959	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
498216002960	tetramer interface [polypeptide binding]; other site
498216002961	active site
498216002962	putative transposase OrfB; Reviewed; Region: PHA02517
498216002963	HTH-like domain; Region: HTH_21; pfam13276
498216002964	Integrase core domain; Region: rve; pfam00665
498216002965	Integrase core domain; Region: rve_2; pfam13333
498216002966	Helix-turn-helix domain; Region: HTH_28; pfam13518
498216002967	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
498216002968	Transposase; Region: HTH_Tnp_1; pfam01527
498216002969	Helix-turn-helix domain; Region: HTH_28; pfam13518
498216002970	Winged helix-turn helix; Region: HTH_29; pfam13551
498216002971	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
498216002972	Sulfatase; Region: Sulfatase; pfam00884
498216002973	Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767
498216002974	Sugar transport protein; Region: Sugar_transport; pfam06800
498216002975	glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097
498216002976	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
498216002977	active site
498216002978	dimer interface [polypeptide binding]; other site
498216002979	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
498216002980	dimer interface [polypeptide binding]; other site
498216002981	active site
498216002982	Domain of unknown function DUF1828; Region: DUF1828; pfam08861
498216002983	Domain of unknown function DUF1829; Region: DUF1829; pfam08862
498216002984	Uncharacterized conserved protein [Function unknown]; Region: COG1359
498216002985	DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; pfam13930
498216002986	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892
498216002987	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
498216002988	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
498216002989	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
498216002990	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
498216002991	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
498216002992	nucleoside/Zn binding site; other site
498216002993	dimer interface [polypeptide binding]; other site
498216002994	catalytic motif [active]
498216002995	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
498216002996	TspO/MBR family; Region: TspO_MBR; pfam03073
498216002997	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
498216002998	Major Facilitator Superfamily; Region: MFS_1; pfam07690
498216002999	putative substrate translocation pore; other site
498216003000	Protein of unknown function (DUF1211); Region: DUF1211; pfam06736
498216003001	Peptidase family C69; Region: Peptidase_C69; pfam03577
498216003002	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
498216003003	catalytic core [active]
498216003004	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
498216003005	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
498216003006	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
498216003007	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
498216003008	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
498216003009	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
498216003010	Walker A/P-loop; other site
498216003011	ATP binding site [chemical binding]; other site
498216003012	Q-loop/lid; other site
498216003013	ABC transporter signature motif; other site
498216003014	Walker B; other site
498216003015	D-loop; other site
498216003016	H-loop/switch region; other site
498216003017	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
498216003018	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
498216003019	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
498216003020	Walker A/P-loop; other site
498216003021	ATP binding site [chemical binding]; other site
498216003022	Q-loop/lid; other site
498216003023	ABC transporter signature motif; other site
498216003024	Walker B; other site
498216003025	D-loop; other site
498216003026	H-loop/switch region; other site
498216003027	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
498216003028	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
498216003029	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255
498216003030	putative metal binding site [ion binding]; other site
498216003031	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
498216003032	active site
498216003033	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
498216003034	Beta-lactamase; Region: Beta-lactamase; pfam00144
498216003035	UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769
498216003036	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
498216003037	Domain of unknown function (DUF1727); Region: DUF1727; pfam08353
498216003038	thymidine kinase; Provisional; Region: PRK04296
498216003039	peptide chain release factor 1; Validated; Region: prfA; PRK00591
498216003040	This domain is found in peptide chain release factors; Region: PCRF; smart00937
498216003041	RF-1 domain; Region: RF-1; pfam00472
498216003042	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
498216003043	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
498216003044	S-adenosylmethionine binding site [chemical binding]; other site
498216003045	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
498216003046	Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481
498216003047	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
498216003048	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
498216003049	dimer interface [polypeptide binding]; other site
498216003050	active site
498216003051	glycine-pyridoxal phosphate binding site [chemical binding]; other site
498216003052	folate binding site [chemical binding]; other site
498216003053	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
498216003054	active site
498216003055	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
498216003056	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
498216003057	F0F1 ATP synthase subunit C; Validated; Region: PRK06876
498216003058	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
498216003059	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
498216003060	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
498216003061	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
498216003062	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
498216003063	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
498216003064	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
498216003065	beta subunit interaction interface [polypeptide binding]; other site
498216003066	Walker A motif; other site
498216003067	ATP binding site [chemical binding]; other site
498216003068	Walker B motif; other site
498216003069	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
498216003070	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
498216003071	core domain interface [polypeptide binding]; other site
498216003072	delta subunit interface [polypeptide binding]; other site
498216003073	epsilon subunit interface [polypeptide binding]; other site
498216003074	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
498216003075	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
498216003076	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
498216003077	alpha subunit interaction interface [polypeptide binding]; other site
498216003078	Walker A motif; other site
498216003079	ATP binding site [chemical binding]; other site
498216003080	Walker B motif; other site
498216003081	inhibitor binding site; inhibition site
498216003082	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
498216003083	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
498216003084	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
498216003085	gamma subunit interface [polypeptide binding]; other site
498216003086	epsilon subunit interface [polypeptide binding]; other site
498216003087	LBP interface [polypeptide binding]; other site
498216003088	Protein of unknown function (DUF1146); Region: DUF1146; cl11486
498216003089	rod shape-determining protein MreB; Provisional; Region: PRK13930
498216003090	MreB and similar proteins; Region: MreB_like; cd10225
498216003091	nucleotide binding site [chemical binding]; other site
498216003092	Mg binding site [ion binding]; other site
498216003093	putative protofilament interaction site [polypeptide binding]; other site
498216003094	RodZ interaction site [polypeptide binding]; other site
498216003095	Haemolytic domain; Region: Haemolytic; cl00506
498216003096	Protein of unknown function (DUF2969); Region: DUF2969; pfam11184
498216003097	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
498216003098	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
498216003099	lipoyl attachment site [posttranslational modification]; other site
498216003100	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588
498216003101	Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659
498216003102	metal binding site [ion binding]; metal-binding site
498216003103	dimer interface [polypeptide binding]; other site
498216003104	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
498216003105	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
498216003106	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
498216003107	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
498216003108	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
498216003109	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
498216003110	Walker A/P-loop; other site
498216003111	ATP binding site [chemical binding]; other site
498216003112	Q-loop/lid; other site
498216003113	ABC transporter signature motif; other site
498216003114	Walker B; other site
498216003115	D-loop; other site
498216003116	H-loop/switch region; other site
498216003117	NIL domain; Region: NIL; pfam09383
498216003118	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
498216003119	dimer interface [polypeptide binding]; other site
498216003120	conserved gate region; other site
498216003121	ABC-ATPase subunit interface; other site
498216003122	Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396
498216003123	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
498216003124	Walker A/P-loop; other site
498216003125	ATP binding site [chemical binding]; other site
498216003126	Q-loop/lid; other site
498216003127	ABC transporter signature motif; other site
498216003128	Walker B; other site
498216003129	D-loop; other site
498216003130	H-loop/switch region; other site
498216003131	Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458
498216003132	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
498216003133	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
498216003134	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
498216003135	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
498216003136	catalytic residue [active]
498216003137	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
498216003138	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
498216003139	trimerization site [polypeptide binding]; other site
498216003140	active site
498216003141	FeS assembly protein SufB; Region: sufB; TIGR01980
498216003142	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
498216003143	Protein of unknown function (DUF1694); Region: DUF1694; pfam07997
498216003144	Protein of unknown function (DUF2785); Region: DUF2785; pfam10978
498216003145	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
498216003146	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
498216003147	active site
498216003148	motif I; other site
498216003149	motif II; other site
498216003150	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
498216003151	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
498216003152	non-specific DNA binding site [nucleotide binding]; other site
498216003153	salt bridge; other site
498216003154	sequence-specific DNA binding site [nucleotide binding]; other site
498216003155	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
498216003156	Ligand Binding Site [chemical binding]; other site
498216003157	recombination factor protein RarA; Reviewed; Region: PRK13342
498216003158	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
498216003159	Walker A motif; other site
498216003160	ATP binding site [chemical binding]; other site
498216003161	Walker B motif; other site
498216003162	arginine finger; other site
498216003163	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
498216003164	D-alanine-D-alanine ligase and related ATP-grasp enzymes [Cell envelope biogenesis, outer membrane]; Region: DdlA; COG1181
498216003165	Protein of unknown function (DUF1694); Region: DUF1694; pfam07997
498216003166	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493
498216003167	Protein of unknown function (DUF1054); Region: DUF1054; pfam06335
498216003168	L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719
498216003169	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
498216003170	C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903
498216003171	putative L-serine binding site [chemical binding]; other site
498216003172	Serine dehydratase alpha chain; Region: SDH_alpha; cl12120
498216003173	L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760
498216003174	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
498216003175	catalytic core [active]
498216003176	methionine sulfoxide reductase A; Provisional; Region: PRK14054
498216003177	short chain dehydrogenase; Provisional; Region: PRK06197
498216003178	retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327
498216003179	putative NAD(P) binding site [chemical binding]; other site
498216003180	active site
498216003181	Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973
498216003182	Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428
498216003183	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
498216003184	active site
498216003185	probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366
498216003186	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
498216003187	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
498216003188	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
498216003189	peptide binding site [polypeptide binding]; other site
498216003190	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
498216003191	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
498216003192	dimer interface [polypeptide binding]; other site
498216003193	phosphorylation site [posttranslational modification]
498216003194	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
498216003195	ATP binding site [chemical binding]; other site
498216003196	Mg2+ binding site [ion binding]; other site
498216003197	G-X-G motif; other site
498216003198	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
498216003199	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
498216003200	active site
498216003201	phosphorylation site [posttranslational modification]
498216003202	intermolecular recognition site; other site
498216003203	dimerization interface [polypeptide binding]; other site
498216003204	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
498216003205	DNA binding site [nucleotide binding]
498216003206	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
498216003207	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
498216003208	Walker A/P-loop; other site
498216003209	ATP binding site [chemical binding]; other site
498216003210	Q-loop/lid; other site
498216003211	ABC transporter signature motif; other site
498216003212	Walker B; other site
498216003213	D-loop; other site
498216003214	H-loop/switch region; other site
498216003215	Transcriptional regulator [Transcription]; Region: LysR; COG0583
498216003216	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
498216003217	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
498216003218	dimerization interface [polypeptide binding]; other site
498216003219	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
498216003220	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
498216003221	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
498216003222	NADH(P)-binding; Region: NAD_binding_10; pfam13460
498216003223	NAD(P) binding site [chemical binding]; other site
498216003224	active site
498216003225	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
498216003226	dimerization interface [polypeptide binding]; other site
498216003227	putative DNA binding site [nucleotide binding]; other site
498216003228	putative Zn2+ binding site [ion binding]; other site
498216003229	glutathionine S-transferase; Provisional; Region: PRK10542
498216003230	GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057
498216003231	C-terminal domain interface [polypeptide binding]; other site
498216003232	GSH binding site (G-site) [chemical binding]; other site
498216003233	dimer interface [polypeptide binding]; other site
498216003234	C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188
498216003235	dimer interface [polypeptide binding]; other site
498216003236	substrate binding pocket (H-site) [chemical binding]; other site
498216003237	N-terminal domain interface [polypeptide binding]; other site
498216003238	SAP domain; Region: SAP; cl02640
498216003239	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
498216003240	Coenzyme A binding pocket [chemical binding]; other site
498216003241	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
498216003242	Coenzyme A binding pocket [chemical binding]; other site
498216003243	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
498216003244	Coenzyme A binding pocket [chemical binding]; other site
498216003245	EDD domain protein, DegV family; Region: DegV; TIGR00762
498216003246	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
498216003247	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
498216003248	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
498216003249	active site
498216003250	phosphorylation site [posttranslational modification]
498216003251	intermolecular recognition site; other site
498216003252	dimerization interface [polypeptide binding]; other site
498216003253	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
498216003254	DNA binding residues [nucleotide binding]
498216003255	dimerization interface [polypeptide binding]; other site
498216003256	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
498216003257	Histidine kinase; Region: HisKA_3; pfam07730
498216003258	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
498216003259	ATP binding site [chemical binding]; other site
498216003260	Mg2+ binding site [ion binding]; other site
498216003261	G-X-G motif; other site
498216003262	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
498216003263	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
498216003264	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
498216003265	Walker A/P-loop; other site
498216003266	ATP binding site [chemical binding]; other site
498216003267	Q-loop/lid; other site
498216003268	ABC transporter signature motif; other site
498216003269	Walker B; other site
498216003270	D-loop; other site
498216003271	H-loop/switch region; other site
498216003272	Protein of unknown function (DUF2568); Region: DUF2568; pfam10823
498216003273	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
498216003274	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
498216003275	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
498216003276	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
498216003277	RNA binding site [nucleotide binding]; other site
498216003278	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
498216003279	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
498216003280	non-specific DNA binding site [nucleotide binding]; other site
498216003281	salt bridge; other site
498216003282	sequence-specific DNA binding site [nucleotide binding]; other site
498216003283	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
498216003284	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
498216003285	non-specific DNA binding site [nucleotide binding]; other site
498216003286	salt bridge; other site
498216003287	sequence-specific DNA binding site [nucleotide binding]; other site
498216003288	Helix-turn-helix domain; Region: HTH_17; pfam12728
498216003289	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
498216003290	Replication protein; Region: Rep_1; pfam01446
498216003291	Helix-turn-helix domain; Region: HTH_17; cl17695
498216003292	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
498216003293	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
498216003294	active site
498216003295	DNA binding site [nucleotide binding]
498216003296	Int/Topo IB signature motif; other site
498216003297	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
498216003298	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
498216003299	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
498216003300	RNA binding surface [nucleotide binding]; other site
498216003301	GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956
498216003302	GAF domain; Region: GAF_2; pfam13185
498216003303	septation ring formation regulator EzrA; Provisional; Region: PRK04778
498216003304	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
498216003305	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
498216003306	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
498216003307	catalytic residue [active]
498216003308	thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565
498216003309	THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716
498216003310	ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712
498216003311	Ligand Binding Site [chemical binding]; other site
498216003312	redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472
498216003313	Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971
498216003314	CoA binding domain; Region: CoA_binding; pfam02629
498216003315	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
498216003316	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
498216003317	active site
498216003318	HIGH motif; other site
498216003319	nucleotide binding site [chemical binding]; other site
498216003320	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
498216003321	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
498216003322	active site
498216003323	KMSKS motif; other site
498216003324	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
498216003325	tRNA binding surface [nucleotide binding]; other site
498216003326	anticodon binding site; other site
498216003327	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
498216003328	folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499
498216003329	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
498216003330	haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509
498216003331	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
498216003332	motif II; other site
498216003333	hypothetical protein; Reviewed; Region: PRK00024
498216003334	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
498216003335	MPN+ (JAMM) motif; other site
498216003336	Zinc-binding site [ion binding]; other site
498216003337	rod shape-determining protein MreB; Provisional; Region: PRK13927
498216003338	MreB and similar proteins; Region: MreB_like; cd10225
498216003339	nucleotide binding site [chemical binding]; other site
498216003340	Mg binding site [ion binding]; other site
498216003341	putative protofilament interaction site [polypeptide binding]; other site
498216003342	RodZ interaction site [polypeptide binding]; other site
498216003343	rod shape-determining protein MreC; Provisional; Region: PRK13922
498216003344	rod shape-determining protein MreC; Region: MreC; pfam04085
498216003345	rod shape-determining protein MreD; Region: shape_MreD; TIGR03426
498216003346	septum formation inhibitor; Reviewed; Region: minC; PRK00513
498216003347	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
498216003348	Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894
498216003349	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
498216003350	Switch I; other site
498216003351	Switch II; other site
498216003352	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
498216003353	dimer interface [polypeptide binding]; other site
498216003354	conserved gate region; other site
498216003355	putative PBP binding loops; other site
498216003356	ABC-ATPase subunit interface; other site
498216003357	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
498216003358	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
498216003359	Walker A/P-loop; other site
498216003360	ATP binding site [chemical binding]; other site
498216003361	Q-loop/lid; other site
498216003362	ABC transporter signature motif; other site
498216003363	Walker B; other site
498216003364	D-loop; other site
498216003365	H-loop/switch region; other site
498216003366	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
498216003367	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
498216003368	substrate binding pocket [chemical binding]; other site
498216003369	membrane-bound complex binding site; other site
498216003370	hinge residues; other site
498216003371	cardiolipin synthetase; Reviewed; Region: cls; PRK01642
498216003372	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
498216003373	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
498216003374	putative active site [active]
498216003375	catalytic site [active]
498216003376	catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112
498216003377	putative active site [active]
498216003378	catalytic site [active]
498216003379	cell division protein MraZ; Reviewed; Region: PRK00326
498216003380	MraZ protein; Region: MraZ; pfam02381
498216003381	MraZ protein; Region: MraZ; pfam02381
498216003382	MraW methylase family; Region: Methyltransf_5; pfam01795
498216003383	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
498216003384	Cell division protein FtsL; Region: FtsL; cl11433
498216003385	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
498216003386	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
498216003387	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
498216003388	PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576
498216003389	PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575
498216003390	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
498216003391	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
498216003392	Mg++ binding site [ion binding]; other site
498216003393	putative catalytic motif [active]
498216003394	putative substrate binding site [chemical binding]; other site
498216003395	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472
498216003396	Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002
498216003397	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
498216003398	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
498216003399	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
498216003400	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
498216003401	active site
498216003402	homodimer interface [polypeptide binding]; other site
498216003403	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
498216003404	Cell division protein FtsQ; Region: FtsQ; pfam03799
498216003405	Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849
498216003406	Cell division protein FtsA; Region: FtsA; smart00842
498216003407	Cell division protein FtsA; Region: FtsA; pfam14450
498216003408	cell division protein FtsZ; Validated; Region: PRK09330
498216003409	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
498216003410	nucleotide binding site [chemical binding]; other site
498216003411	SulA interaction site; other site
498216003412	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799
498216003413	YGGT family; Region: YGGT; pfam02325
498216003414	Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302
498216003415	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
498216003416	RNA binding surface [nucleotide binding]; other site
498216003417	DivIVA protein; Region: DivIVA; pfam05103
498216003418	DivIVA domain; Region: DivI1A_domain; TIGR03544
498216003419	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
498216003420	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
498216003421	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
498216003422	active site
498216003423	HIGH motif; other site
498216003424	nucleotide binding site [chemical binding]; other site
498216003425	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
498216003426	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
498216003427	active site
498216003428	KMSKS motif; other site
498216003429	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
498216003430	tRNA binding surface [nucleotide binding]; other site
498216003431	anticodon binding site; other site
498216003432	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
498216003433	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
498216003434	DNA-binding site [nucleotide binding]; DNA binding site
498216003435	RNA-binding motif; other site
498216003436	PBP superfamily domain; Region: PBP_like_2; cl17296
498216003437	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
498216003438	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
498216003439	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
498216003440	putative substrate translocation pore; other site
498216003441	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
498216003442	Toxic anion resistance protein (TelA); Region: TelA; pfam05816
498216003443	5-bromo-4-chloroindolyl phosphate hydrolysis protein; Region: Halogen_Hydrol; pfam10112
498216003444	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
498216003445	dimer interface [polypeptide binding]; other site
498216003446	ADP-ribose binding site [chemical binding]; other site
498216003447	active site
498216003448	nudix motif; other site
498216003449	metal binding site [ion binding]; metal-binding site
498216003450	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584
498216003451	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704
498216003452	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
498216003453	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
498216003454	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
498216003455	catalytic residue [active]
498216003456	Putative amino acid metabolism; Region: DUF1831; pfam08866
498216003457	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
498216003458	Walker A/P-loop; other site
498216003459	ATP binding site [chemical binding]; other site
498216003460	Q-loop/lid; other site
498216003461	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
498216003462	ABC transporter signature motif; other site
498216003463	Walker B; other site
498216003464	D-loop; other site
498216003465	H-loop/switch region; other site
498216003466	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
498216003467	AAA domain; Region: AAA_21; pfam13304
498216003468	Walker A/P-loop; other site
498216003469	ATP binding site [chemical binding]; other site
498216003470	Q-loop/lid; other site
498216003471	ABC transporter signature motif; other site
498216003472	Walker B; other site
498216003473	D-loop; other site
498216003474	H-loop/switch region; other site
498216003475	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
498216003476	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
498216003477	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
498216003478	catalytic core [active]
498216003479	helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448
498216003480	H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815
498216003481	AAA domain; Region: AAA_30; pfam13604
498216003482	Family description; Region: UvrD_C_2; pfam13538
498216003483	Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527
498216003484	Sterol carrier protein domain; Region: SCP2_2; pfam13530
498216003485	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
498216003486	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
498216003487	Diacylglycerol kinase accessory domain; Region: DAGK_acc; cl02440
498216003488	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
498216003489	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
498216003490	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
498216003491	Protein of unknown function (DUF1447); Region: DUF1447; pfam07288
498216003492	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
498216003493	active site
498216003494	catalytic residues [active]
498216003495	metal binding site [ion binding]; metal-binding site
498216003496	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
498216003497	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
498216003498	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181
498216003499	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
498216003500	TPP-binding site [chemical binding]; other site
498216003501	tetramer interface [polypeptide binding]; other site
498216003502	heterodimer interface [polypeptide binding]; other site
498216003503	phosphorylation loop region [posttranslational modification]
498216003504	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
498216003505	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
498216003506	alpha subunit interface [polypeptide binding]; other site
498216003507	TPP binding site [chemical binding]; other site
498216003508	heterodimer interface [polypeptide binding]; other site
498216003509	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
498216003510	dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855
498216003511	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
498216003512	E3 interaction surface; other site
498216003513	lipoyl attachment site [posttranslational modification]; other site
498216003514	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
498216003515	E3 interaction surface; other site
498216003516	lipoyl attachment site [posttranslational modification]; other site
498216003517	e3 binding domain; Region: E3_binding; pfam02817
498216003518	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
498216003519	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
498216003520	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
498216003521	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
498216003522	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
498216003523	NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195
498216003524	NAD(P) binding site [chemical binding]; other site
498216003525	substrate binding site [chemical binding]; other site
498216003526	Uncharacterized protein family (UPF0223); Region: UPF0223; pfam05256
498216003527	Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637
498216003528	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
498216003529	active site
498216003530	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
498216003531	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
498216003532	G1 box; other site
498216003533	putative GEF interaction site [polypeptide binding]; other site
498216003534	GTP/Mg2+ binding site [chemical binding]; other site
498216003535	Switch I region; other site
498216003536	G2 box; other site
498216003537	G3 box; other site
498216003538	Switch II region; other site
498216003539	G4 box; other site
498216003540	G5 box; other site
498216003541	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
498216003542	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
498216003543	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
498216003544	pyruvate carboxylase; Reviewed; Region: PRK12999
498216003545	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
498216003546	ATP-grasp domain; Region: ATP-grasp_4; cl17255
498216003547	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
498216003548	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
498216003549	active site
498216003550	catalytic residues [active]
498216003551	metal binding site [ion binding]; metal-binding site
498216003552	homodimer binding site [polypeptide binding]; other site
498216003553	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
498216003554	carboxyltransferase (CT) interaction site; other site
498216003555	biotinylation site [posttranslational modification]; other site
498216003556	Uncharacterized protein conserved in bacteria (DUF2129); Region: DUF2129; pfam09902
498216003557	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
498216003558	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
498216003559	S-adenosylmethionine binding site [chemical binding]; other site
498216003560	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
498216003561	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
498216003562	active site
498216003563	(T/H)XGH motif; other site
498216003564	Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480
498216003565	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117
498216003566	protein binding site [polypeptide binding]; other site
498216003567	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
498216003568	SLBB domain; Region: SLBB; pfam10531
498216003569	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
498216003570	Helix-hairpin-helix motif; Region: HHH; pfam00633
498216003571	Competence protein; Region: Competence; pfam03772
498216003572	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
498216003573	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
498216003574	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574
498216003575	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
498216003576	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
498216003577	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
498216003578	16S/18S rRNA binding site [nucleotide binding]; other site
498216003579	S13e-L30e interaction site [polypeptide binding]; other site
498216003580	25S rRNA binding site [nucleotide binding]; other site
498216003581	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
498216003582	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
498216003583	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
498216003584	elongation factor Tu; Reviewed; Region: PRK00049
498216003585	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
498216003586	G1 box; other site
498216003587	GEF interaction site [polypeptide binding]; other site
498216003588	GTP/Mg2+ binding site [chemical binding]; other site
498216003589	Switch I region; other site
498216003590	G2 box; other site
498216003591	G3 box; other site
498216003592	Switch II region; other site
498216003593	G4 box; other site
498216003594	G5 box; other site
498216003595	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
498216003596	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
498216003597	Antibiotic Binding Site [chemical binding]; other site
498216003598	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
498216003599	Homeodomain-like domain; Region: HTH_23; pfam13384
498216003600	Transposase; Region: DDE_Tnp_ISL3; pfam01610
498216003601	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
498216003602	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
498216003603	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
498216003604	Walker A/P-loop; other site
498216003605	ATP binding site [chemical binding]; other site
498216003606	Q-loop/lid; other site
498216003607	ABC transporter signature motif; other site
498216003608	Walker B; other site
498216003609	D-loop; other site
498216003610	H-loop/switch region; other site
498216003611	trigger factor; Provisional; Region: tig; PRK01490
498216003612	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
498216003613	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
498216003614	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
498216003615	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
498216003616	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
498216003617	Walker A motif; other site
498216003618	ATP binding site [chemical binding]; other site
498216003619	Walker B motif; other site
498216003620	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
498216003621	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
498216003622	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
498216003623	putative active site [active]
498216003624	putative NTP binding site [chemical binding]; other site
498216003625	putative nucleic acid binding site [nucleotide binding]; other site
498216003626	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
498216003627	Elongation factor Tu GTP binding domain; Region: GTP_EFTU; pfam00009
498216003628	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
498216003629	G1 box; other site
498216003630	GTP/Mg2+ binding site [chemical binding]; other site
498216003631	Switch I region; other site
498216003632	G2 box; other site
498216003633	G3 box; other site
498216003634	Switch II region; other site
498216003635	G4 box; other site
498216003636	G5 box; other site
498216003637	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u4; cd11541
498216003638	putative metal binding site [ion binding]; other site
498216003639	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
498216003640	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
498216003641	substrate binding pocket [chemical binding]; other site
498216003642	membrane-bound complex binding site; other site
498216003643	hinge residues; other site
498216003644	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
498216003645	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
498216003646	dimer interface [polypeptide binding]; other site
498216003647	conserved gate region; other site
498216003648	putative PBP binding loops; other site
498216003649	ABC-ATPase subunit interface; other site
498216003650	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
498216003651	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
498216003652	Walker A/P-loop; other site
498216003653	ATP binding site [chemical binding]; other site
498216003654	Q-loop/lid; other site
498216003655	ABC transporter signature motif; other site
498216003656	Walker B; other site
498216003657	D-loop; other site
498216003658	H-loop/switch region; other site
498216003659	Pleckstrin homology-like domain; Region: PH-like; cl17171
498216003660	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
498216003661	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
498216003662	GIY-YIG motif/motif A; other site
498216003663	active site
498216003664	catalytic site [active]
498216003665	putative DNA binding site [nucleotide binding]; other site
498216003666	metal binding site [ion binding]; metal-binding site
498216003667	UvrB/uvrC motif; Region: UVR; pfam02151
498216003668	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
498216003669	PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765
498216003670	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
498216003671	active site
498216003672	phosphorylation site [posttranslational modification]
498216003673	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
498216003674	active site
498216003675	P-loop; other site
498216003676	phosphorylation site [posttranslational modification]
498216003677	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
498216003678	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
498216003679	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
498216003680	putative substrate binding site [chemical binding]; other site
498216003681	putative ATP binding site [chemical binding]; other site
498216003682	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
498216003683	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
498216003684	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
498216003685	GTPase CgtA; Reviewed; Region: obgE; PRK12297
498216003686	GTP1/OBG; Region: GTP1_OBG; pfam01018
498216003687	Obg GTPase; Region: Obg; cd01898
498216003688	G1 box; other site
498216003689	GTP/Mg2+ binding site [chemical binding]; other site
498216003690	Switch I region; other site
498216003691	G2 box; other site
498216003692	G3 box; other site
498216003693	Switch II region; other site
498216003694	G4 box; other site
498216003695	G5 box; other site
498216003696	Domain of unknown function (DUF1967); Region: DUF1967; pfam09269
498216003697	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
498216003698	yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840
498216003699	catalytic triad [active]
498216003700	catalytic triad [active]
498216003701	oxyanion hole [active]
498216003702	ribonuclease Z; Region: RNase_Z; TIGR02651
498216003703	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
498216003704	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
498216003705	NAD(P) binding site [chemical binding]; other site
498216003706	active site
498216003707	Protein of unknown function (DUF1049); Region: DUF1049; pfam06305
498216003708	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
498216003709	Clp amino terminal domain; Region: Clp_N; pfam02861
498216003710	Clp amino terminal domain; Region: Clp_N; pfam02861
498216003711	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
498216003712	Walker A motif; other site
498216003713	ATP binding site [chemical binding]; other site
498216003714	Walker B motif; other site
498216003715	arginine finger; other site
498216003716	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
498216003717	Walker A motif; other site
498216003718	ATP binding site [chemical binding]; other site
498216003719	Walker B motif; other site
498216003720	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
498216003721	50S ribosomal protein L32; Validated; Region: rpmF; PRK01110
498216003722	Domain of unknown function (DUF1836); Region: DUF1836; pfam08876
498216003723	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
498216003724	Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410
498216003725	active site
498216003726	metal binding site [ion binding]; metal-binding site
498216003727	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
498216003728	Protein of unknown function (DUF2929); Region: DUF2929; pfam11151
498216003729	DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587
498216003730	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431
498216003731	active site
498216003732	PHP Thumb interface [polypeptide binding]; other site
498216003733	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
498216003734	generic binding surface I; other site
498216003735	generic binding surface II; other site
498216003736	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763
498216003737	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
498216003738	active site
498216003739	ADP/pyrophosphate binding site [chemical binding]; other site
498216003740	dimerization interface [polypeptide binding]; other site
498216003741	allosteric effector site; other site
498216003742	fructose-1,6-bisphosphate binding site; other site
498216003743	pyruvate kinase; Provisional; Region: PRK06354
498216003744	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
498216003745	domain interfaces; other site
498216003746	active site
498216003747	Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848
498216003748	Protein of unknown function (DUF441); Region: DUF441; pfam04284
498216003749	Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996
498216003750	S1 domain; Region: S1_2; pfam13509
498216003751	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
498216003752	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
498216003753	active site
498216003754	Int/Topo IB signature motif; other site
498216003755	segregation and condensation protein A; Reviewed; Region: scpA; PRK00104
498216003756	segregation and condensation protein B; Reviewed; Region: scpB; PRK00135
498216003757	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
498216003758	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
498216003759	RNA binding surface [nucleotide binding]; other site
498216003760	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
498216003761	active site
498216003762	Predicted membrane protein [Function unknown]; Region: COG3601
498216003763	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
498216003764	4Fe-4S single cluster domain; Region: Fer4_13; pfam13370
498216003765	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955
498216003766	Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514
498216003767	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
498216003768	ATP binding site [chemical binding]; other site
498216003769	putative Mg++ binding site [ion binding]; other site
498216003770	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
498216003771	nucleotide binding region [chemical binding]; other site
498216003772	ATP-binding site [chemical binding]; other site
498216003773	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
498216003774	cytidylate kinase; Provisional; Region: cmk; PRK00023
498216003775	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
498216003776	CMP-binding site; other site
498216003777	The sites determining sugar specificity; other site
498216003778	GTP-binding protein Der; Reviewed; Region: PRK00093
498216003779	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
498216003780	G1 box; other site
498216003781	GTP/Mg2+ binding site [chemical binding]; other site
498216003782	Switch I region; other site
498216003783	G2 box; other site
498216003784	Switch II region; other site
498216003785	G3 box; other site
498216003786	G4 box; other site
498216003787	G5 box; other site
498216003788	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
498216003789	G1 box; other site
498216003790	GTP/Mg2+ binding site [chemical binding]; other site
498216003791	Switch I region; other site
498216003792	G2 box; other site
498216003793	G3 box; other site
498216003794	Switch II region; other site
498216003795	G4 box; other site
498216003796	G5 box; other site
498216003797	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
498216003798	IHF dimer interface [polypeptide binding]; other site
498216003799	IHF - DNA interface [nucleotide binding]; other site
498216003800	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
498216003801	TPR motif; other site
498216003802	binding surface
498216003803	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
498216003804	binding surface
498216003805	TPR motif; other site
498216003806	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
498216003807	binding surface
498216003808	TPR motif; other site
498216003809	TPR repeat; Region: TPR_11; pfam13414
498216003810	Uncharacterized conserved protein [Function unknown]; Region: COG1284
498216003811	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
498216003812	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
498216003813	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
498216003814	tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299
498216003815	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
498216003816	active site
498216003817	NTP binding site [chemical binding]; other site
498216003818	metal binding triad [ion binding]; metal-binding site
498216003819	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
498216003820	tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735
498216003821	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
498216003822	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
498216003823	Walker A/P-loop; other site
498216003824	ATP binding site [chemical binding]; other site
498216003825	Q-loop/lid; other site
498216003826	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
498216003827	ABC transporter signature motif; other site
498216003828	Walker B; other site
498216003829	D-loop; other site
498216003830	ABC transporter; Region: ABC_tran_2; pfam12848
498216003831	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
498216003832	thymidylate synthase; Region: thym_sym; TIGR03284
498216003833	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
498216003834	dimerization interface [polypeptide binding]; other site
498216003835	active site
498216003836	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
498216003837	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
498216003838	folate binding site [chemical binding]; other site
498216003839	NADP+ binding site [chemical binding]; other site
498216003840	Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272
498216003841	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
498216003842	EDD domain protein, DegV family; Region: DegV; TIGR00762
498216003843	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
498216003844	Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506
498216003845	active site
498216003846	catalytic triad [active]
498216003847	oxyanion hole [active]
498216003848	Uncharacterized protein conserved in bacteria (DUF2140); Region: DUF2140; pfam09911
498216003849	methionine sulfoxide reductase A; Provisional; Region: PRK14054
498216003850	hypothetical protein; Provisional; Region: PRK13672
498216003851	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
498216003852	C-terminal peptidase (prc); Region: prc; TIGR00225
498216003853	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
498216003854	protein binding site [polypeptide binding]; other site
498216003855	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
498216003856	Catalytic dyad [active]
498216003857	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
498216003858	ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596
498216003859	Circularly permuted YlqF GTPase; Region: YlqF; cd01856
498216003860	GTP/Mg2+ binding site [chemical binding]; other site
498216003861	G4 box; other site
498216003862	G5 box; other site
498216003863	G1 box; other site
498216003864	Switch I region; other site
498216003865	G2 box; other site
498216003866	G3 box; other site
498216003867	Switch II region; other site
498216003868	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
498216003869	RNA/DNA hybrid binding site [nucleotide binding]; other site
498216003870	active site
498216003871	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
498216003872	DNA protecting protein DprA; Region: dprA; TIGR00732
498216003873	DNA topoisomerase I; Validated; Region: PRK05582
498216003874	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
498216003875	active site
498216003876	interdomain interaction site; other site
498216003877	putative metal-binding site [ion binding]; other site
498216003878	nucleotide binding site [chemical binding]; other site
498216003879	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
498216003880	domain I; other site
498216003881	DNA binding groove [nucleotide binding]
498216003882	phosphate binding site [ion binding]; other site
498216003883	domain II; other site
498216003884	domain III; other site
498216003885	nucleotide binding site [chemical binding]; other site
498216003886	catalytic site [active]
498216003887	domain IV; other site
498216003888	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
498216003889	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
498216003890	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
498216003891	Glucose inhibited division protein A; Region: GIDA; pfam01134
498216003892	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
498216003893	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
498216003894	active site
498216003895	Int/Topo IB signature motif; other site
498216003896	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
498216003897	active site
498216003898	HslU subunit interaction site [polypeptide binding]; other site
498216003899	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
498216003900	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
498216003901	Walker A motif; other site
498216003902	ATP binding site [chemical binding]; other site
498216003903	AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724
498216003904	Walker B motif; other site
498216003905	arginine finger; other site
498216003906	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
498216003907	Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024
498216003908	active site
498216003909	catalytic residues [active]
498216003910	membrane protein; Provisional; Region: PRK14392
498216003911	DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559
498216003912	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
498216003913	Mg2+ binding site [ion binding]; other site
498216003914	G-X-G motif; other site
498216003915	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
498216003916	anchoring element; other site
498216003917	dimer interface [polypeptide binding]; other site
498216003918	ATP binding site [chemical binding]; other site
498216003919	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
498216003920	active site
498216003921	putative metal-binding site [ion binding]; other site
498216003922	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
498216003923	DNA topoisomerase IV subunit A; Validated; Region: PRK05561
498216003924	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
498216003925	CAP-like domain; other site
498216003926	active site
498216003927	primary dimer interface [polypeptide binding]; other site
498216003928	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
498216003929	formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255
498216003930	Pyruvate formate lyase 1; Region: PFL1; cd01678
498216003931	coenzyme A binding site [chemical binding]; other site
498216003932	active site
498216003933	catalytic residues [active]
498216003934	glycine loop; other site
498216003935	pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493
498216003936	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
498216003937	FeS/SAM binding site; other site
498216003938	Transcriptional regulator [Transcription]; Region: LysR; COG0583
498216003939	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
498216003940	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
498216003941	dimerization interface [polypeptide binding]; other site
498216003942	putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427
498216003943	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
498216003944	DHHA2 domain; Region: DHHA2; pfam02833
498216003945	site-specific tyrosine recombinase XerS; Reviewed; Region: xerS; PRK05084
498216003946	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
498216003947	active site
498216003948	DNA binding site [nucleotide binding]
498216003949	Int/Topo IB signature motif; other site
498216003950	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
498216003951	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
498216003952	Walker A/P-loop; other site
498216003953	ATP binding site [chemical binding]; other site
498216003954	Q-loop/lid; other site
498216003955	ABC transporter signature motif; other site
498216003956	Walker B; other site
498216003957	D-loop; other site
498216003958	H-loop/switch region; other site
498216003959	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
498216003960	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
498216003961	ATP binding site [chemical binding]; other site
498216003962	Mg2+ binding site [ion binding]; other site
498216003963	G-X-G motif; other site
498216003964	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
498216003965	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
498216003966	active site
498216003967	phosphorylation site [posttranslational modification]
498216003968	intermolecular recognition site; other site
498216003969	dimerization interface [polypeptide binding]; other site
498216003970	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
498216003971	DNA binding site [nucleotide binding]
498216003972	H+ Antiporter protein; Region: 2A0121; TIGR00900
498216003973	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
498216003974	putative substrate translocation pore; other site
498216003975	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
498216003976	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
498216003977	Coenzyme A binding pocket [chemical binding]; other site
498216003978	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
498216003979	Coenzyme A binding pocket [chemical binding]; other site
498216003980	Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137
498216003981	dimer interface [polypeptide binding]; other site
498216003982	FMN binding site [chemical binding]; other site
498216003983	histidinol-phosphate aminotransferase; Provisional; Region: PRK03158
498216003984	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
498216003985	pyridoxal 5'-phosphate binding site [chemical binding]; other site
498216003986	homodimer interface [polypeptide binding]; other site
498216003987	catalytic residue [active]
498216003988	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
498216003989	metal binding site [ion binding]; metal-binding site
498216003990	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
498216003991	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
498216003992	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
498216003993	substrate binding site [chemical binding]; other site
498216003994	glutamase interaction surface [polypeptide binding]; other site
498216003995	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
498216003996	phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007
498216003997	catalytic residues [active]
498216003998	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141
498216003999	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
498216004000	putative active site [active]
498216004001	oxyanion strand; other site
498216004002	catalytic triad [active]
498216004003	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
498216004004	4-fold oligomerization interface [polypeptide binding]; other site
498216004005	putative active site pocket [active]
498216004006	metal binding residues [ion binding]; metal-binding site
498216004007	3-fold/trimer interface [polypeptide binding]; other site
498216004008	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
498216004009	histidinol dehydrogenase; Region: hisD; TIGR00069
498216004010	NAD binding site [chemical binding]; other site
498216004011	dimerization interface [polypeptide binding]; other site
498216004012	product binding site; other site
498216004013	substrate binding site [chemical binding]; other site
498216004014	zinc binding site [ion binding]; other site
498216004015	catalytic residues [active]
498216004016	ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686
498216004017	ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040
498216004018	ATP phosphoribosyltransferase, regulatory subunit; Region: hisZ_biosyn_reg; TIGR00443
498216004019	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
498216004020	dimer interface [polypeptide binding]; other site
498216004021	motif 1; other site
498216004022	active site
498216004023	motif 2; other site
498216004024	motif 3; other site
498216004025	histidinol-phosphate aminotransferase; Provisional; Region: PRK03158
498216004026	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
498216004027	pyridoxal 5'-phosphate binding site [chemical binding]; other site
498216004028	homodimer interface [polypeptide binding]; other site
498216004029	catalytic residue [active]
498216004030	GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009
498216004031	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
498216004032	dimer interface [polypeptide binding]; other site
498216004033	ADP-ribose binding site [chemical binding]; other site
498216004034	active site
498216004035	nudix motif; other site
498216004036	metal binding site [ion binding]; metal-binding site
498216004037	EDD domain protein, DegV family; Region: DegV; TIGR00762
498216004038	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
498216004039	Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833
498216004040	Domain of unknown function (DUF814); Region: DUF814; pfam05670
498216004041	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Sulfolobus solfataricus (Ss) and its homologs from archaea and bacteria; Region: NTP-PPase_SsMazG; cd11535
498216004042	metal binding site [ion binding]; metal-binding site
498216004043	Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641
498216004044	Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303
498216004045	2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
498216004046	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
498216004047	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
498216004048	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
498216004049	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
498216004050	E3 interaction surface; other site
498216004051	lipoyl attachment site [posttranslational modification]; other site
498216004052	e3 binding domain; Region: E3_binding; pfam02817
498216004053	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
498216004054	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
498216004055	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
498216004056	alpha subunit interface [polypeptide binding]; other site
498216004057	TPP binding site [chemical binding]; other site
498216004058	heterodimer interface [polypeptide binding]; other site
498216004059	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
498216004060	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181
498216004061	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
498216004062	tetramer interface [polypeptide binding]; other site
498216004063	TPP-binding site [chemical binding]; other site
498216004064	heterodimer interface [polypeptide binding]; other site
498216004065	phosphorylation loop region [posttranslational modification]
498216004066	dihydrolipoamide dehydrogenase; Validated; Region: PRK05976
498216004067	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
498216004068	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
498216004069	butyrate kinase; Provisional; Region: PRK03011
498216004070	Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212
498216004071	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
498216004072	active site
498216004073	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
498216004074	active site
498216004075	dimer interface [polypeptide binding]; other site
498216004076	Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740
498216004077	dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037
498216004078	heterodimer interface [polypeptide binding]; other site
498216004079	active site
498216004080	FMN binding site [chemical binding]; other site
498216004081	homodimer interface [polypeptide binding]; other site
498216004082	substrate binding site [chemical binding]; other site
498216004083	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
498216004084	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
498216004085	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
498216004086	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
498216004087	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
498216004088	ATP-grasp domain; Region: ATP-grasp_4; cl17255
498216004089	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
498216004090	IMP binding site; other site
498216004091	dimer interface [polypeptide binding]; other site
498216004092	interdomain contacts; other site
498216004093	partial ornithine binding site; other site
498216004094	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
498216004095	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
498216004096	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
498216004097	catalytic site [active]
498216004098	subunit interface [polypeptide binding]; other site
498216004099	dihydroorotase; Validated; Region: pyrC; PRK09357
498216004100	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
498216004101	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
498216004102	active site
498216004103	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
498216004104	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
498216004105	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
498216004106	uracil transporter; Provisional; Region: PRK10720
498216004107	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
498216004108	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
498216004109	active site
498216004110	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
498216004111	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
498216004112	RNA binding surface [nucleotide binding]; other site
498216004113	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
498216004114	active site
498216004115	lipoprotein signal peptidase; Provisional; Region: PRK14797
498216004116	formate--tetrahydrofolate ligase; Provisional; Region: PRK13505
498216004117	Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477
498216004118	Potassium binding sites [ion binding]; other site
498216004119	Cesium cation binding sites [ion binding]; other site
498216004120	RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279
498216004121	RNA/DNA hybrid binding site [nucleotide binding]; other site
498216004122	active site
498216004123	Nitroreductase-like family 4.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140
498216004124	dimer interface [polypeptide binding]; other site
498216004125	FMN binding site [chemical binding]; other site
498216004126	cardiolipin synthase; Region: bac_cardiolipin; TIGR04265
498216004127	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
498216004128	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
498216004129	putative active site [active]
498216004130	catalytic site [active]
498216004131	catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112
498216004132	putative active site [active]
498216004133	catalytic site [active]
498216004134	Mga helix-turn-helix domain; Region: Mga; pfam05043
498216004135	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
498216004136	catalytic residues [active]
498216004137	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07306
498216004138	Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343
498216004139	Class I ribonucleotide reductase; Region: RNR_I; cd01679
498216004140	active site
498216004141	dimer interface [polypeptide binding]; other site
498216004142	catalytic residues [active]
498216004143	effector binding site; other site
498216004144	R2 peptide binding site; other site
498216004145	ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966
498216004146	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
498216004147	dimer interface [polypeptide binding]; other site
498216004148	putative radical transfer pathway; other site
498216004149	diiron center [ion binding]; other site
498216004150	tyrosyl radical; other site
498216004151	Transcriptional regulator [Transcription]; Region: LysR; COG0583
498216004152	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
498216004153	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
498216004154	dimerization interface [polypeptide binding]; other site
498216004155	Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590
498216004156	Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662
498216004157	active site
498216004158	Zn binding site [ion binding]; other site
498216004159	lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545
498216004160	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
498216004161	Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437
498216004162	Phosphoglycerate Dehydrogenase, 2-hydroxyacid dehydrogenase family; Region: PGDH_1; cd12155
498216004163	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
498216004164	putative ligand binding site [chemical binding]; other site
498216004165	NAD binding site [chemical binding]; other site
498216004166	catalytic site [active]
498216004167	Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116
498216004168	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
498216004169	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
498216004170	cell division protein GpsB; Provisional; Region: PRK14127
498216004171	DivIVA domain; Region: DivI1A_domain; TIGR03544
498216004172	hypothetical protein; Provisional; Region: PRK13660
498216004173	Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234
498216004174	Transglycosylase; Region: Transgly; pfam00912
498216004175	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
498216004176	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
498216004177	Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286
498216004178	catalytic motif [active]
498216004179	Zn binding site [ion binding]; other site
498216004180	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
498216004181	endonuclease III; Region: ENDO3c; smart00478
498216004182	minor groove reading motif; other site
498216004183	helix-hairpin-helix signature motif; other site
498216004184	substrate binding pocket [chemical binding]; other site
498216004185	active site
498216004186	Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935
498216004187	Replication initiation and membrane attachment; Region: DnaB_2; pfam07261
498216004188	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
498216004189	AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs.  This domain is a...; Region: AsnRS_cyto_like_N; cd04323
498216004190	putative dimer interface [polypeptide binding]; other site
498216004191	putative anticodon binding site; other site
498216004192	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
498216004193	homodimer interface [polypeptide binding]; other site
498216004194	motif 1; other site
498216004195	motif 2; other site
498216004196	active site
498216004197	motif 3; other site
498216004198	aspartate aminotransferase; Provisional; Region: PRK05764
498216004199	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
498216004200	pyridoxal 5'-phosphate binding site [chemical binding]; other site
498216004201	homodimer interface [polypeptide binding]; other site
498216004202	catalytic residue [active]
498216004203	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353
498216004204	DnaQ family exonuclease/DinG family helicase, putative; Region: dinG_rel; TIGR01407
498216004205	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
498216004206	active site
498216004207	catalytic site [active]
498216004208	substrate binding site [chemical binding]; other site
498216004209	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
498216004210	helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785
498216004211	DEAD/DEAH box helicase; Region: DEAD; pfam00270
498216004212	ATP binding site [chemical binding]; other site
498216004213	Family description; Region: UvrD_C_2; pfam13538
498216004214	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
498216004215	helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773
498216004216	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
498216004217	mevalonate kinase; Region: mevalon_kin; TIGR00549
498216004218	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
498216004219	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
498216004220	diphosphomevalonate decarboxylase; Region: PLN02407
498216004221	Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407
498216004222	isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437
498216004223	Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811
498216004224	homotetramer interface [polypeptide binding]; other site
498216004225	FMN binding site [chemical binding]; other site
498216004226	homodimer contacts [polypeptide binding]; other site
498216004227	putative active site [active]
498216004228	putative substrate binding site [chemical binding]; other site
498216004229	tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144
498216004230	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
498216004231	S-adenosylmethionine binding site [chemical binding]; other site
498216004232	pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636
498216004233	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
498216004234	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
498216004235	4-oxalocrotonate tautomerase; Provisional; Region: PRK02220
498216004236	active site 1 [active]
498216004237	dimer interface [polypeptide binding]; other site
498216004238	hexamer interface [polypeptide binding]; other site
498216004239	active site 2 [active]
498216004240	Uncharacterized conserved protein [Function unknown]; Region: COG0327
498216004241	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
498216004242	Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384
498216004243	Family of unknown function (DUF633); Region: DUF633; pfam04816
498216004244	RNA polymerase sigma factor RpoD; Validated; Region: PRK09210
498216004245	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
498216004246	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
498216004247	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
498216004248	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
498216004249	DNA binding residues [nucleotide binding]
498216004250	DNA primase; Validated; Region: dnaG; PRK05667
498216004251	CHC2 zinc finger; Region: zf-CHC2; pfam01807
498216004252	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
498216004253	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
498216004254	active site
498216004255	metal binding site [ion binding]; metal-binding site
498216004256	interdomain interaction site; other site
498216004257	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
498216004258	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
498216004259	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
498216004260	dimer interface [polypeptide binding]; other site
498216004261	motif 1; other site
498216004262	active site
498216004263	motif 2; other site
498216004264	motif 3; other site
498216004265	Recombination protein O N terminal; Region: RecO_N; pfam11967
498216004266	DNA repair protein RecO; Region: reco; TIGR00613
498216004267	Recombination protein O C terminal; Region: RecO_C; pfam02565
498216004268	GTPase Era; Reviewed; Region: era; PRK00089
498216004269	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
498216004270	G1 box; other site
498216004271	GTP/Mg2+ binding site [chemical binding]; other site
498216004272	Switch I region; other site
498216004273	G2 box; other site
498216004274	Switch II region; other site
498216004275	G3 box; other site
498216004276	G4 box; other site
498216004277	G5 box; other site
498216004278	KH domain; Region: KH_2; pfam07650
498216004279	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
498216004280	active site
498216004281	catalytic motif [active]
498216004282	Zn binding site [ion binding]; other site
498216004283	Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818
498216004284	metal-binding heat shock protein; Provisional; Region: PRK00016
498216004285	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
498216004286	PhoH-like protein; Region: PhoH; pfam02562
498216004287	Yqey-like protein; Region: YqeY; pfam09424
498216004288	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
498216004289	Kinase/pyrophosphorylase; Region: Kinase-PPPase; pfam03618
498216004290	endonuclease IV; Provisional; Region: PRK01060
498216004291	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
498216004292	AP (apurinic/apyrimidinic) site pocket; other site
498216004293	DNA interaction; other site
498216004294	Metal-binding active site; metal-binding site
498216004295	Uncharacterized conserved protein [Function unknown]; Region: COG1284
498216004296	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
498216004297	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
498216004298	methionine sulfoxide reductase B; Provisional; Region: PRK00222
498216004299	SelR domain; Region: SelR; pfam01641
498216004300	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
498216004301	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
498216004302	dimer interface [polypeptide binding]; other site
498216004303	anticodon binding site; other site
498216004304	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
498216004305	homodimer interface [polypeptide binding]; other site
498216004306	motif 1; other site
498216004307	active site
498216004308	motif 2; other site
498216004309	GAD domain; Region: GAD; pfam02938
498216004310	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
498216004311	motif 3; other site
498216004312	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
498216004313	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
498216004314	dimer interface [polypeptide binding]; other site
498216004315	motif 1; other site
498216004316	active site
498216004317	motif 2; other site
498216004318	motif 3; other site
498216004319	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
498216004320	anticodon binding site; other site
498216004321	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cl00217
498216004322	metal binding sites [ion binding]; metal-binding site
498216004323	dimer interface [polypeptide binding]; other site
498216004324	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
498216004325	ABC-type multidrug transport system, ATPase component; Region: ABC_drug_resistance_like; cd03264
498216004326	Walker A/P-loop; other site
498216004327	ATP binding site [chemical binding]; other site
498216004328	Q-loop/lid; other site
498216004329	ABC transporter signature motif; other site
498216004330	Walker B; other site
498216004331	D-loop; other site
498216004332	H-loop/switch region; other site
498216004333	HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228
498216004334	Bacterial SH3 domain; Region: SH3_3; pfam08239
498216004335	Bacterial SH3 domain; Region: SH3_3; pfam08239
498216004336	Bacterial SH3 domain homologues; Region: SH3b; smart00287
498216004337	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
498216004338	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
498216004339	active site
498216004340	metal binding site [ion binding]; metal-binding site
498216004341	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
498216004342	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
498216004343	motif II; other site
498216004344	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
498216004345	putative active site [active]
498216004346	dimerization interface [polypeptide binding]; other site
498216004347	putative tRNAtyr binding site [nucleotide binding]; other site
498216004348	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
498216004349	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
498216004350	Zn2+ binding site [ion binding]; other site
498216004351	Mg2+ binding site [ion binding]; other site
498216004352	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
498216004353	synthetase active site [active]
498216004354	NTP binding site [chemical binding]; other site
498216004355	metal binding site [ion binding]; metal-binding site
498216004356	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
498216004357	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
498216004358	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385
498216004359	RNA methyltransferase, RsmE family; Region: TIGR00046
498216004360	Ribosomal protein L11 methylase [Translation, ribosomal structure and biogenesis]; Region: PrmA; COG2264
498216004361	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
498216004362	S-adenosylmethionine binding site [chemical binding]; other site
498216004363	Protein of unknown function (DUF3013); Region: DUF3013; pfam11217
498216004364	Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540
498216004365	active site
498216004366	DNA binding site [nucleotide binding]
498216004367	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
498216004368	Homeodomain-like domain; Region: HTH_23; pfam13384
498216004369	Transposase; Region: DDE_Tnp_ISL3; pfam01610
498216004370	Protein of unknown function (DUF1093); Region: DUF1093; pfam06486
498216004371	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
498216004372	Coenzyme A binding pocket [chemical binding]; other site
498216004373	Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525
498216004374	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
498216004375	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
498216004376	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
498216004377	WHG domain; Region: WHG; pfam13305
498216004378	N-formylglutamate amidohydrolase; Region: FGase; pfam05013
498216004379	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
498216004380	Homeodomain-like domain; Region: HTH_23; pfam13384
498216004381	Transposase; Region: DDE_Tnp_ISL3; pfam01610
498216004382	Staphylococcal protein of unknown function (DUF960); Region: DUF960; pfam06124
498216004383	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
498216004384	putative deacylase active site [active]
498216004385	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
498216004386	active site
498216004387	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
498216004388	DHH family; Region: DHH; pfam01368
498216004389	Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; cl11538
498216004390	ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553
498216004391	GTP-binding protein LepA; Provisional; Region: PRK05433
498216004392	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
498216004393	G1 box; other site
498216004394	putative GEF interaction site [polypeptide binding]; other site
498216004395	GTP/Mg2+ binding site [chemical binding]; other site
498216004396	Switch I region; other site
498216004397	G2 box; other site
498216004398	G3 box; other site
498216004399	Switch II region; other site
498216004400	G4 box; other site
498216004401	G5 box; other site
498216004402	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
498216004403	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
498216004404	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
498216004405	chaperone protein DnaJ; Provisional; Region: PRK14276
498216004406	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
498216004407	HSP70 interaction site [polypeptide binding]; other site
498216004408	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
498216004409	substrate binding site [polypeptide binding]; other site
498216004410	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
498216004411	Zn binding sites [ion binding]; other site
498216004412	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
498216004413	dimer interface [polypeptide binding]; other site
498216004414	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
498216004415	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
498216004416	nucleotide binding site [chemical binding]; other site
498216004417	NEF interaction site [polypeptide binding]; other site
498216004418	SBD interface [polypeptide binding]; other site
498216004419	GrpE; Region: GrpE; pfam01025
498216004420	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
498216004421	dimer interface [polypeptide binding]; other site
498216004422	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
498216004423	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
498216004424	HTH domain; Region: HTH_11; pfam08279
498216004425	coproporphyrinogen III oxidase; Provisional; Region: PRK08599
498216004426	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
498216004427	FeS/SAM binding site; other site
498216004428	HemN C-terminal domain; Region: HemN_C; pfam06969
498216004429	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
498216004430	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
498216004431	active site
498216004432	Riboflavin kinase; Region: Flavokinase; smart00904
498216004433	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK02484
498216004434	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
498216004435	RNA binding site [nucleotide binding]; other site
498216004436	active site
498216004437	integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716
498216004438	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
498216004439	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
498216004440	translation initiation factor IF-2; Region: IF-2; TIGR00487
498216004441	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
498216004442	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
498216004443	G1 box; other site
498216004444	putative GEF interaction site [polypeptide binding]; other site
498216004445	GTP/Mg2+ binding site [chemical binding]; other site
498216004446	Switch I region; other site
498216004447	G2 box; other site
498216004448	G3 box; other site
498216004449	Switch II region; other site
498216004450	G4 box; other site
498216004451	G5 box; other site
498216004452	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
498216004453	Translation-initiation factor 2; Region: IF-2; pfam11987
498216004454	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
498216004455	Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600
498216004456	Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279
498216004457	putative RNA binding cleft [nucleotide binding]; other site
498216004458	transcription elongation factor NusA; Provisional; Region: nusA; PRK12327
498216004459	NusA N-terminal domain; Region: NusA_N; pfam08529
498216004460	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
498216004461	RNA binding site [nucleotide binding]; other site
498216004462	homodimer interface [polypeptide binding]; other site
498216004463	NusA-like KH domain; Region: KH_5; pfam13184
498216004464	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
498216004465	G-X-X-G motif; other site
498216004466	ribosome maturation protein RimP; Reviewed; Region: PRK00092
498216004467	Sm and related proteins; Region: Sm_like; cl00259
498216004468	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
498216004469	putative oligomer interface [polypeptide binding]; other site
498216004470	putative RNA binding site [nucleotide binding]; other site
498216004471	DNA polymerase III PolC; Validated; Region: polC; PRK00448
498216004472	DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490
498216004473	polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484
498216004474	generic binding surface II; other site
498216004475	generic binding surface I; other site
498216004476	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
498216004477	active site
498216004478	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
498216004479	active site
498216004480	catalytic site [active]
498216004481	substrate binding site [chemical binding]; other site
498216004482	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435
498216004483	prolyl-tRNA synthetase; Provisional; Region: PRK09194
498216004484	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
498216004485	dimer interface [polypeptide binding]; other site
498216004486	motif 1; other site
498216004487	active site
498216004488	motif 2; other site
498216004489	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
498216004490	putative deacylase active site [active]
498216004491	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
498216004492	active site
498216004493	motif 3; other site
498216004494	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
498216004495	anticodon binding site; other site
498216004496	RIP metalloprotease RseP; Region: TIGR00054
498216004497	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
498216004498	active site
498216004499	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
498216004500	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
498216004501	protein binding site [polypeptide binding]; other site
498216004502	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
498216004503	putative substrate binding region [chemical binding]; other site
498216004504	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
498216004505	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
498216004506	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
498216004507	undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14830
498216004508	catalytic residue [active]
498216004509	putative FPP diphosphate  binding site; other site
498216004510	putative FPP binding hydrophobic cleft; other site
498216004511	dimer interface [polypeptide binding]; other site
498216004512	putative IPP diphosphate binding site; other site
498216004513	ribosome recycling factor; Reviewed; Region: frr; PRK00083
498216004514	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
498216004515	hinge region; other site
498216004516	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
498216004517	putative nucleotide binding site [chemical binding]; other site
498216004518	uridine monophosphate binding site [chemical binding]; other site
498216004519	homohexameric interface [polypeptide binding]; other site
498216004520	elongation factor Ts; Provisional; Region: tsf; PRK09377
498216004521	UBA/TS-N domain; Region: UBA; pfam00627
498216004522	Elongation factor TS; Region: EF_TS; pfam00889
498216004523	Elongation factor TS; Region: EF_TS; pfam00889
498216004524	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
498216004525	rRNA interaction site [nucleotide binding]; other site
498216004526	S8 interaction site; other site
498216004527	putative laminin-1 binding site; other site
498216004528	The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456
498216004529	GIY-YIG motif/motif A; other site
498216004530	putative active site [active]
498216004531	putative metal binding site [ion binding]; other site
498216004532	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
498216004533	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
498216004534	S-adenosylmethionine binding site [chemical binding]; other site
498216004535	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
498216004536	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
498216004537	putative acyl-acceptor binding pocket; other site
498216004538	amino acid transporter; Region: 2A0306; TIGR00909
498216004539	Spore germination protein; Region: Spore_permease; cl17796
498216004540	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
498216004541	Protein of unknown function (DUF1003); Region: DUF1003; pfam06210
498216004542	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
498216004543	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
498216004544	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
498216004545	Walker A/P-loop; other site
498216004546	ATP binding site [chemical binding]; other site
498216004547	Q-loop/lid; other site
498216004548	ABC transporter signature motif; other site
498216004549	Walker B; other site
498216004550	D-loop; other site
498216004551	H-loop/switch region; other site
498216004552	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
498216004553	putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789
498216004554	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
498216004555	Walker A/P-loop; other site
498216004556	ATP binding site [chemical binding]; other site
498216004557	Q-loop/lid; other site
498216004558	ABC transporter signature motif; other site
498216004559	Walker B; other site
498216004560	D-loop; other site
498216004561	H-loop/switch region; other site
498216004562	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3763
498216004563	Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979
498216004564	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
498216004565	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
498216004566	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
498216004567	RimM N-terminal domain; Region: RimM; pfam01782
498216004568	PRC-barrel domain; Region: PRC; pfam05239
498216004569	Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837
498216004570	KH domain; Region: KH_4; pfam13083
498216004571	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
498216004572	signal recognition particle protein; Provisional; Region: PRK10867
498216004573	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
498216004574	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
498216004575	P loop; other site
498216004576	GTP binding site [chemical binding]; other site
498216004577	Signal peptide binding domain; Region: SRP_SPB; pfam02978
498216004578	Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297
498216004579	putative DNA-binding protein; Validated; Region: PRK00118
498216004580	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
498216004581	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
498216004582	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
498216004583	P loop; other site
498216004584	GTP binding site [chemical binding]; other site
498216004585	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
498216004586	AAA domain; Region: AAA_23; pfam13476
498216004587	Walker A/P-loop; other site
498216004588	ATP binding site [chemical binding]; other site
498216004589	Q-loop/lid; other site
498216004590	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968
498216004591	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
498216004592	ABC transporter signature motif; other site
498216004593	Walker B; other site
498216004594	D-loop; other site
498216004595	H-loop/switch region; other site
498216004596	ribonuclease III, bacterial; Region: RNaseIII; TIGR02191
498216004597	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
498216004598	dimerization interface [polypeptide binding]; other site
498216004599	active site
498216004600	metal binding site [ion binding]; metal-binding site
498216004601	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
498216004602	The substrate binding component of an ABC-type lactococcal OppA-like transport system contains; Region: PBP2_Lactococcal_OppA_like; cd08510
498216004603	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
498216004604	peptide binding site [polypeptide binding]; other site
498216004605	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
498216004606	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
498216004607	dimer interface [polypeptide binding]; other site
498216004608	conserved gate region; other site
498216004609	putative PBP binding loops; other site
498216004610	ABC-ATPase subunit interface; other site
498216004611	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
498216004612	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
498216004613	dimer interface [polypeptide binding]; other site
498216004614	conserved gate region; other site
498216004615	putative PBP binding loops; other site
498216004616	ABC-ATPase subunit interface; other site
498216004617	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
498216004618	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
498216004619	Walker A/P-loop; other site
498216004620	ATP binding site [chemical binding]; other site
498216004621	Q-loop/lid; other site
498216004622	ABC transporter signature motif; other site
498216004623	Walker B; other site
498216004624	D-loop; other site
498216004625	H-loop/switch region; other site
498216004626	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
498216004627	acyl carrier protein; Provisional; Region: acpP; PRK00982
498216004628	putative phosphate acyltransferase; Provisional; Region: PRK05331
498216004629	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
498216004630	Y-family of DNA polymerases; Region: PolY; cl12025
498216004631	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
498216004632	generic binding surface II; other site
498216004633	ssDNA binding site; other site
498216004634	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
498216004635	ATP binding site [chemical binding]; other site
498216004636	putative Mg++ binding site [ion binding]; other site
498216004637	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
498216004638	nucleotide binding region [chemical binding]; other site
498216004639	ATP-binding site [chemical binding]; other site
498216004640	DAK2 domain fusion protein YloV; Region: YloV; TIGR03599
498216004641	DAK2 domain; Region: Dak2; pfam02734
498216004642	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302
498216004643	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
498216004644	Thiamine pyrophosphokinase; Region: TPK; cd07995
498216004645	thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378
498216004646	active site
498216004647	dimerization interface [polypeptide binding]; other site
498216004648	thiamine binding site [chemical binding]; other site
498216004649	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
498216004650	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
498216004651	substrate binding site [chemical binding]; other site
498216004652	hexamer interface [polypeptide binding]; other site
498216004653	metal binding site [ion binding]; metal-binding site
498216004654	GTPase RsgA; Reviewed; Region: PRK00098
498216004655	S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466
498216004656	RNA binding site [nucleotide binding]; other site
498216004657	homodimer interface [polypeptide binding]; other site
498216004658	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
498216004659	GTPase/Zn-binding domain interface [polypeptide binding]; other site
498216004660	GTP/Mg2+ binding site [chemical binding]; other site
498216004661	G4 box; other site
498216004662	G5 box; other site
498216004663	G1 box; other site
498216004664	Switch I region; other site
498216004665	G2 box; other site
498216004666	G3 box; other site
498216004667	Switch II region; other site
498216004668	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
498216004669	Catalytic domain of Protein Kinases; Region: PKc; cd00180
498216004670	active site
498216004671	ATP binding site [chemical binding]; other site
498216004672	substrate binding site [chemical binding]; other site
498216004673	activation loop (A-loop); other site
498216004674	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815
498216004675	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
498216004676	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
498216004677	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
498216004678	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
498216004679	active site
498216004680	16S rRNA methyltransferase B; Provisional; Region: PRK14902
498216004681	NusB family; Region: NusB; pfam01029
498216004682	putative RNA binding site [nucleotide binding]; other site
498216004683	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
498216004684	S-adenosylmethionine binding site [chemical binding]; other site
498216004685	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
498216004686	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
498216004687	putative active site [active]
498216004688	substrate binding site [chemical binding]; other site
498216004689	putative cosubstrate binding site; other site
498216004690	catalytic site [active]
498216004691	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
498216004692	substrate binding site [chemical binding]; other site
498216004693	primosome assembly protein PriA; Validated; Region: PRK05580
498216004694	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
498216004695	ATP binding site [chemical binding]; other site
498216004696	putative Mg++ binding site [ion binding]; other site
498216004697	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
498216004698	nucleotide binding region [chemical binding]; other site
498216004699	ATP-binding site [chemical binding]; other site
498216004700	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
498216004701	Flavoprotein; Region: Flavoprotein; pfam02441
498216004702	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
498216004703	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
498216004704	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
498216004705	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
498216004706	catalytic site [active]
498216004707	G-X2-G-X-G-K; other site
498216004708	Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209
498216004709	nucleophile elbow; other site
498216004710	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
498216004711	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
498216004712	Walker A/P-loop; other site
498216004713	ATP binding site [chemical binding]; other site
498216004714	Q-loop/lid; other site
498216004715	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
498216004716	ABC transporter signature motif; other site
498216004717	Walker B; other site
498216004718	D-loop; other site
498216004719	H-loop/switch region; other site
498216004720	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
498216004721	arginine repressor; Provisional; Region: PRK04280
498216004722	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
498216004723	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
498216004724	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
498216004725	RNA binding surface [nucleotide binding]; other site
498216004726	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
498216004727	S-adenosylmethionine binding site [chemical binding]; other site
498216004728	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
498216004729	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
498216004730	substrate binding pocket [chemical binding]; other site
498216004731	chain length determination region; other site
498216004732	substrate-Mg2+ binding site; other site
498216004733	catalytic residues [active]
498216004734	aspartate-rich region 1; other site
498216004735	active site lid residues [active]
498216004736	aspartate-rich region 2; other site
498216004737	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
498216004738	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
498216004739	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
498216004740	generic binding surface II; other site
498216004741	generic binding surface I; other site
498216004742	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14169
498216004743	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
498216004744	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
498216004745	homodimer interface [polypeptide binding]; other site
498216004746	NADP binding site [chemical binding]; other site
498216004747	substrate binding site [chemical binding]; other site
498216004748	transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202
498216004749	putative RNA binding site [nucleotide binding]; other site
498216004750	Asp23 family; Region: Asp23; pfam03780
498216004751	elongation factor P; Validated; Region: PRK00529
498216004752	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
498216004753	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
498216004754	RNA binding site [nucleotide binding]; other site
498216004755	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
498216004756	RNA binding site [nucleotide binding]; other site
498216004757	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
498216004758	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
498216004759	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
498216004760	active site
498216004761	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
498216004762	Protein of unknown function (DUF464); Region: DUF464; pfam04327
498216004763	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
498216004764	x-prolyl-dipeptidyl aminopeptidase; Provisional; Region: PRK05371
498216004765	X-Prolyl dipeptidyl aminopeptidase PepX, N-terminal; Region: PepX_N; pfam09168
498216004766	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530
498216004767	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
498216004768	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
498216004769	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
498216004770	Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105
498216004771	DNA binding residues [nucleotide binding]
498216004772	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
498216004773	putative dimer interface [polypeptide binding]; other site
498216004774	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
498216004775	Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982
498216004776	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
498216004777	catalytic residue [active]
498216004778	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
498216004779	Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100
498216004780	Aluminium resistance protein; Region: Alum_res; pfam06838
498216004781	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
498216004782	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
498216004783	Protein of unknown function (DUF3042); Region: DUF3042; pfam11240
498216004784	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
498216004785	active site residue [active]
498216004786	ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744
498216004787	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
498216004788	nucleotide binding site [chemical binding]; other site
498216004789	Bacterial protein of unknown function (DUF910); Region: DUF910; pfam06014
498216004790	Rhomboid family; Region: Rhomboid; pfam01694
498216004791	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
498216004792	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
498216004793	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
498216004794	Bacterial membrane protein YfhO; Region: YfhO; pfam09586
498216004795	Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400
498216004796	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
498216004797	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
498216004798	active site
498216004799	phosphorylation site [posttranslational modification]
498216004800	intermolecular recognition site; other site
498216004801	dimerization interface [polypeptide binding]; other site
498216004802	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
498216004803	DNA binding residues [nucleotide binding]
498216004804	dimerization interface [polypeptide binding]; other site
498216004805	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
498216004806	Histidine kinase; Region: HisKA_3; pfam07730
498216004807	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
498216004808	ATP binding site [chemical binding]; other site
498216004809	Mg2+ binding site [ion binding]; other site
498216004810	G-X-G motif; other site
498216004811	Predicted membrane protein [Function unknown]; Region: COG4758
498216004812	Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922
498216004813	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
498216004814	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
498216004815	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
498216004816	Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572
498216004817	Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023
498216004818	ATP-binding site [chemical binding]; other site
498216004819	Sugar specificity; other site
498216004820	Pyrimidine base specificity; other site
498216004821	YceG-like family; Region: YceG; pfam02618
498216004822	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
498216004823	dimerization interface [polypeptide binding]; other site
498216004824	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
498216004825	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
498216004826	putative tRNA-binding site [nucleotide binding]; other site
498216004827	B3/4 domain; Region: B3_4; pfam03483
498216004828	tRNA synthetase B5 domain; Region: B5; smart00874
498216004829	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
498216004830	dimer interface [polypeptide binding]; other site
498216004831	motif 1; other site
498216004832	motif 3; other site
498216004833	motif 2; other site
498216004834	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
498216004835	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
498216004836	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
498216004837	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
498216004838	dimer interface [polypeptide binding]; other site
498216004839	motif 1; other site
498216004840	active site
498216004841	motif 2; other site
498216004842	motif 3; other site
498216004843	Predicted transcriptional regulators [Transcription]; Region: COG1733
498216004844	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
498216004845	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
498216004846	Zn2+ binding site [ion binding]; other site
498216004847	Mg2+ binding site [ion binding]; other site
498216004848	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
498216004849	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
498216004850	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
498216004851	Acylphosphatases [Energy production and conversion]; Region: AcyP; COG1254
498216004852	OxaA-like protein precursor; Provisional; Region: PRK02463
498216004853	60Kd inner membrane protein; Region: 60KD_IMP; cl00489
498216004854	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
498216004855	HAMP domain; Region: HAMP; pfam00672
498216004856	dimerization interface [polypeptide binding]; other site
498216004857	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
498216004858	dimer interface [polypeptide binding]; other site
498216004859	phosphorylation site [posttranslational modification]
498216004860	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
498216004861	ATP binding site [chemical binding]; other site
498216004862	Mg2+ binding site [ion binding]; other site
498216004863	G-X-G motif; other site
498216004864	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
498216004865	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
498216004866	active site
498216004867	phosphorylation site [posttranslational modification]
498216004868	intermolecular recognition site; other site
498216004869	dimerization interface [polypeptide binding]; other site
498216004870	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
498216004871	DNA binding site [nucleotide binding]
498216004872	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
498216004873	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
498216004874	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
498216004875	Protein of unknown function (DUF3781); Region: DUF3781; pfam12636
498216004876	Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399
498216004877	hypothetical protein; Provisional; Region: PRK13670
498216004878	HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673
498216004879	SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500
498216004880	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
498216004881	S-adenosylmethionine binding site [chemical binding]; other site
498216004882	Oligomerisation domain; Region: Oligomerisation; pfam02410
498216004883	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
498216004884	Zn2+ binding site [ion binding]; other site
498216004885	Mg2+ binding site [ion binding]; other site
498216004886	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
498216004887	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
498216004888	active site
498216004889	(T/H)XGH motif; other site
498216004890	Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534
498216004891	GTPase YqeH; Provisional; Region: PRK13796
498216004892	Circularly permuted YqeH GTPase; Region: YqeH; cd01855
498216004893	GTP/Mg2+ binding site [chemical binding]; other site
498216004894	G4 box; other site
498216004895	G5 box; other site
498216004896	G1 box; other site
498216004897	Switch I region; other site
498216004898	G2 box; other site
498216004899	G3 box; other site
498216004900	Switch II region; other site
498216004901	Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179
498216004902	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
498216004903	active site
498216004904	motif I; other site
498216004905	motif II; other site
498216004906	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
498216004907	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
498216004908	Zn binding site [ion binding]; other site
498216004909	C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347
498216004910	Zn binding site [ion binding]; other site
498216004911	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
498216004912	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
498216004913	Zn binding site [ion binding]; other site
498216004914	C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347
498216004915	Zn binding site [ion binding]; other site
498216004916	Predicted esterase [General function prediction only]; Region: COG0400
498216004917	putative hydrolase; Provisional; Region: PRK11460
498216004918	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
498216004919	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
498216004920	putative NAD(P) binding site [chemical binding]; other site
498216004921	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
498216004922	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
498216004923	23S rRNA binding site [nucleotide binding]; other site
498216004924	L21 binding site [polypeptide binding]; other site
498216004925	L13 binding site [polypeptide binding]; other site
498216004926	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
498216004927	translation initiation factor IF-3; Region: infC; TIGR00168
498216004928	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
498216004929	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
498216004930	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
498216004931	catalytic core [active]
498216004932	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
498216004933	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
498216004934	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
498216004935	active site
498216004936	dimer interface [polypeptide binding]; other site
498216004937	motif 1; other site
498216004938	motif 2; other site
498216004939	motif 3; other site
498216004940	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
498216004941	anticodon binding site; other site
498216004942	primosomal protein DnaI; Reviewed; Region: PRK08939
498216004943	Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319
498216004944	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
498216004945	Walker A motif; other site
498216004946	ATP binding site [chemical binding]; other site
498216004947	Walker B motif; other site
498216004948	Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611
498216004949	Replication initiation and membrane attachment; Region: DnaB_2; cl12121
498216004950	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
498216004951	ATP cone domain; Region: ATP-cone; pfam03477
498216004952	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
498216004953	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
498216004954	CoA-binding site [chemical binding]; other site
498216004955	ATP-binding [chemical binding]; other site
498216004956	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
498216004957	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
498216004958	DNA binding site [nucleotide binding]
498216004959	catalytic residue [active]
498216004960	H2TH interface [polypeptide binding]; other site
498216004961	putative catalytic residues [active]
498216004962	turnover-facilitating residue; other site
498216004963	intercalation triad [nucleotide binding]; other site
498216004964	8OG recognition residue [nucleotide binding]; other site
498216004965	putative reading head residues; other site
498216004966	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
498216004967	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
498216004968	DNA polymerase I; Provisional; Region: PRK05755
498216004969	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
498216004970	active site
498216004971	metal binding site 1 [ion binding]; metal-binding site
498216004972	putative 5' ssDNA interaction site; other site
498216004973	metal binding site 3; metal-binding site
498216004974	metal binding site 2 [ion binding]; metal-binding site
498216004975	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
498216004976	putative DNA binding site [nucleotide binding]; other site
498216004977	putative metal binding site [ion binding]; other site
498216004978	inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140
498216004979	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
498216004980	active site
498216004981	DNA binding site [nucleotide binding]
498216004982	catalytic site [active]
498216004983	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
498216004984	Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432
498216004985	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
498216004986	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
498216004987	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
498216004988	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
498216004989	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
498216004990	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
498216004991	This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843
498216004992	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
498216004993	putative tRNA-binding site [nucleotide binding]; other site
498216004994	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
498216004995	catalytic residues [active]
498216004996	Predicted small secreted protein [Function unknown]; Region: COG5584
498216004997	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
498216004998	S-adenosylmethionine binding site [chemical binding]; other site
498216004999	Thiamine kinase and related kinases [Coenzyme transport and metabolism]; Region: ycfN; COG0510
498216005000	Phosphotransferase enzyme family; Region: APH; pfam01636
498216005001	substrate binding site [chemical binding]; other site
498216005002	Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975
498216005003	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
498216005004	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
498216005005	Walker A/P-loop; other site
498216005006	ATP binding site [chemical binding]; other site
498216005007	Q-loop/lid; other site
498216005008	ABC transporter signature motif; other site
498216005009	Walker B; other site
498216005010	D-loop; other site
498216005011	H-loop/switch region; other site
498216005012	HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277
498216005013	HIT family signature motif; other site
498216005014	catalytic residue [active]
498216005015	YtxH-like protein; Region: YtxH; pfam12732
498216005016	3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480
498216005017	YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492
498216005018	generic binding surface I; other site
498216005019	generic binding surface II; other site
498216005020	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
498216005021	Zn2+ binding site [ion binding]; other site
498216005022	Mg2+ binding site [ion binding]; other site
498216005023	Protein of unknown function (DUF964); Region: DUF964; cl01483
498216005024	Transglycosylase; Region: Transgly; pfam00912
498216005025	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
498216005026	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
498216005027	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
498216005028	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
498216005029	active site
498216005030	Arginine repressor [Transcription]; Region: ArgR; COG1438
498216005031	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
498216005032	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
498216005033	arginyl-tRNA synthetase; Reviewed; Region: PRK12451
498216005034	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
498216005035	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
498216005036	active site
498216005037	HIGH motif; other site
498216005038	KMSK motif region; other site
498216005039	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
498216005040	tRNA binding surface [nucleotide binding]; other site
498216005041	anticodon binding site; other site
498216005042	dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037
498216005043	Dihydroorotate dehydrogenase (DHOD) class 1A FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1A_like; cd04741
498216005044	active site
498216005045	FMN binding site [chemical binding]; other site
498216005046	substrate binding site [chemical binding]; other site
498216005047	catalytic residues [active]
498216005048	homodimer interface [polypeptide binding]; other site
498216005049	Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; pfam10110
498216005050	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
498216005051	Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579
498216005052	putative active site [active]
498216005053	catalytic site [active]
498216005054	putative metal binding site [ion binding]; other site
498216005055	adaptor protein; Provisional; Region: PRK02315
498216005056	Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032
498216005057	ArsC family; Region: ArsC; pfam03960
498216005058	putative catalytic residues [active]
498216005059	thiol/disulfide switch; other site
498216005060	Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234
498216005061	FtsX-like permease family; Region: FtsX; pfam02687
498216005062	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
498216005063	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
498216005064	Walker A/P-loop; other site
498216005065	ATP binding site [chemical binding]; other site
498216005066	Q-loop/lid; other site
498216005067	ABC transporter signature motif; other site
498216005068	Walker B; other site
498216005069	D-loop; other site
498216005070	H-loop/switch region; other site
498216005071	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
498216005072	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
498216005073	active site
498216005074	phosphorylation site [posttranslational modification]
498216005075	intermolecular recognition site; other site
498216005076	dimerization interface [polypeptide binding]; other site
498216005077	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
498216005078	DNA binding site [nucleotide binding]
498216005079	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
498216005080	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
498216005081	ATP binding site [chemical binding]; other site
498216005082	Mg2+ binding site [ion binding]; other site
498216005083	G-X-G motif; other site
498216005084	anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804
498216005085	4Fe-4S single cluster domain; Region: Fer4_12; pfam13353
498216005086	copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511
498216005087	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
498216005088	copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698
498216005089	Penicillinase repressor; Region: Pencillinase_R; pfam03965
498216005090	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
498216005091	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
498216005092	ATP-grasp domain; Region: ATP-grasp_4; cl17255
498216005093	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
498216005094	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
498216005095	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
498216005096	purine monophosphate binding site [chemical binding]; other site
498216005097	dimer interface [polypeptide binding]; other site
498216005098	putative catalytic residues [active]
498216005099	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
498216005100	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
498216005101	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
498216005102	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
498216005103	active site
498216005104	substrate binding site [chemical binding]; other site
498216005105	cosubstrate binding site; other site
498216005106	catalytic site [active]
498216005107	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
498216005108	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
498216005109	dimerization interface [polypeptide binding]; other site
498216005110	putative ATP binding site [chemical binding]; other site
498216005111	amidophosphoribosyltransferase; Provisional; Region: PRK07272
498216005112	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
498216005113	active site
498216005114	tetramer interface [polypeptide binding]; other site
498216005115	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
498216005116	active site
498216005117	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
498216005118	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
498216005119	dimerization interface [polypeptide binding]; other site
498216005120	ATP binding site [chemical binding]; other site
498216005121	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
498216005122	dimerization interface [polypeptide binding]; other site
498216005123	ATP binding site [chemical binding]; other site
498216005124	phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619
498216005125	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
498216005126	putative active site [active]
498216005127	catalytic triad [active]
498216005128	Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700
498216005129	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
498216005130	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
498216005131	ATP binding site [chemical binding]; other site
498216005132	active site
498216005133	substrate binding site [chemical binding]; other site
498216005134	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
498216005135	ATP-grasp domain; Region: ATP-grasp; pfam02222
498216005136	AIR carboxylase; Region: AIRC; pfam00731
498216005137	Thiamine transporter protein (Thia_YuaJ); Region: Thia_YuaJ; pfam09515
498216005138	MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879
498216005139	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
498216005140	putative substrate translocation pore; other site
498216005141	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
498216005142	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
498216005143	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
498216005144	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
498216005145	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
498216005146	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
498216005147	dimerization domain swap beta strand [polypeptide binding]; other site
498216005148	regulatory protein interface [polypeptide binding]; other site
498216005149	active site
498216005150	regulatory phosphorylation site [posttranslational modification]; other site
498216005151	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
498216005152	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
498216005153	Walker A motif; other site
498216005154	ATP binding site [chemical binding]; other site
498216005155	Walker B motif; other site
498216005156	arginine finger; other site
498216005157	UvrB/uvrC motif; Region: UVR; pfam02151
498216005158	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
498216005159	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
498216005160	Walker A motif; other site
498216005161	ATP binding site [chemical binding]; other site
498216005162	Walker B motif; other site
498216005163	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
498216005164	Domain of unknown function (DUF1827); Region: DUF1827; pfam08860
498216005165	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
498216005166	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
498216005167	G1 box; other site
498216005168	putative GEF interaction site [polypeptide binding]; other site
498216005169	GTP/Mg2+ binding site [chemical binding]; other site
498216005170	Switch I region; other site
498216005171	G2 box; other site
498216005172	G3 box; other site
498216005173	Switch II region; other site
498216005174	G4 box; other site
498216005175	G5 box; other site
498216005176	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
498216005177	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
498216005178	Domain of unknown function DUF21; Region: DUF21; pfam01595
498216005179	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
498216005180	Transporter associated domain; Region: CorC_HlyC; pfam03471
498216005181	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
498216005182	Domain of unknown function DUF20; Region: UPF0118; pfam01594
498216005183	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
498216005184	Coenzyme A binding pocket [chemical binding]; other site
498216005185	hypothetical protein; Provisional; Region: PRK13662
498216005186	RecX family; Region: RecX; cl00936
498216005187	Mga helix-turn-helix domain; Region: Mga; pfam05043
498216005188	TRAM domain; Region: TRAM; pfam01938
498216005189	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
498216005190	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
498216005191	S-adenosylmethionine binding site [chemical binding]; other site
498216005192	Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014
498216005193	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
498216005194	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
498216005195	DNA-binding site [nucleotide binding]; DNA binding site
498216005196	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
498216005197	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
498216005198	beta-galactosidase; Region: BGL; TIGR03356
498216005199	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
498216005200	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
498216005201	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
498216005202	active site
498216005203	methionine cluster; other site
498216005204	phosphorylation site [posttranslational modification]
498216005205	metal binding site [ion binding]; metal-binding site
498216005206	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
498216005207	active site
498216005208	P-loop; other site
498216005209	phosphorylation site [posttranslational modification]
498216005210	Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039
498216005211	pyruvate oxidase; Region: pyruv_oxi_spxB; TIGR02720
498216005212	PYR/PP interface [polypeptide binding]; other site
498216005213	dimer interface [polypeptide binding]; other site
498216005214	tetramer interface [polypeptide binding]; other site
498216005215	TPP binding site [chemical binding]; other site
498216005216	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
498216005217	Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014
498216005218	TPP-binding site [chemical binding]; other site
498216005219	"initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827
498216005220	3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835
498216005221	dimer interface [polypeptide binding]; other site
498216005222	active site
498216005223	Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644
498216005224	homodimer interface [polypeptide binding]; other site
498216005225	catalytic residues [active]
498216005226	NAD binding site [chemical binding]; other site
498216005227	substrate binding pocket [chemical binding]; other site
498216005228	flexible flap; other site
498216005229	putative acyltransferase; Provisional; Region: PRK05790
498216005230	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
498216005231	dimer interface [polypeptide binding]; other site
498216005232	active site
498216005233	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
498216005234	Restriction endonuclease; Region: Mrr_cat; pfam04471
498216005235	aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648
498216005236	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588
498216005237	Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659
498216005238	metal binding site [ion binding]; metal-binding site
498216005239	dimer interface [polypeptide binding]; other site
498216005240	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
498216005241	Predicted membrane protein [Function unknown]; Region: COG4684
498216005242	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
498216005243	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
498216005244	Coenzyme A binding pocket [chemical binding]; other site
498216005245	hypothetical protein; Provisional; Region: PRK04351
498216005246	SprT homologues; Region: SprT; cl01182
498216005247	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101
498216005248	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
498216005249	Walker A/P-loop; other site
498216005250	ATP binding site [chemical binding]; other site
498216005251	Q-loop/lid; other site
498216005252	ABC transporter signature motif; other site
498216005253	Walker B; other site
498216005254	D-loop; other site
498216005255	H-loop/switch region; other site
498216005256	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574
498216005257	TM-ABC transporter signature motif; other site
498216005258	Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325
498216005259	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
498216005260	zinc binding site [ion binding]; other site
498216005261	putative ligand binding site [chemical binding]; other site
498216005262	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
498216005263	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
498216005264	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
498216005265	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
498216005266	Soluble P-type ATPase [General function prediction only]; Region: COG4087
498216005267	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
498216005268	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
498216005269	Beta-lactamase; Region: Beta-lactamase; pfam00144
498216005270	NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171
498216005271	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
498216005272	homodimer interface [polypeptide binding]; other site
498216005273	NAD binding pocket [chemical binding]; other site
498216005274	ATP binding pocket [chemical binding]; other site
498216005275	Mg binding site [ion binding]; other site
498216005276	active-site loop [active]
498216005277	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
498216005278	Beta-lactamase; Region: Beta-lactamase; pfam00144
498216005279	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
498216005280	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
498216005281	active site
498216005282	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
498216005283	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
498216005284	DNA-binding site [nucleotide binding]; DNA binding site
498216005285	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
498216005286	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
498216005287	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
498216005288	active site
498216005289	dimer interface [polypeptide binding]; other site
498216005290	Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345
498216005291	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
498216005292	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
498216005293	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
498216005294	putative phosphoesterase; Region: acc_ester; TIGR03729
498216005295	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
498216005296	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
498216005297	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
498216005298	putative substrate translocation pore; other site
498216005299	POT family; Region: PTR2; pfam00854
498216005300	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
498216005301	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
498216005302	Walker A/P-loop; other site
498216005303	ATP binding site [chemical binding]; other site
498216005304	Q-loop/lid; other site
498216005305	ABC transporter signature motif; other site
498216005306	Walker B; other site
498216005307	D-loop; other site
498216005308	H-loop/switch region; other site
498216005309	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
498216005310	FtsX-like permease family; Region: FtsX; pfam02687
498216005311	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
498216005312	Homeodomain-like domain; Region: HTH_23; pfam13384
498216005313	Transposase; Region: DDE_Tnp_ISL3; pfam01610
498216005314	MFS/sugar transport protein; Region: MFS_2; pfam13347
498216005315	melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392
498216005316	Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119
498216005317	Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669
498216005318	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
498216005319	catalytic residues [active]
498216005320	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270
498216005321	active site
498216005322	nucleotide-binding site [chemical binding]; other site
498216005323	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
498216005324	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
498216005325	G1 box; other site
498216005326	GTP/Mg2+ binding site [chemical binding]; other site
498216005327	Switch I region; other site
498216005328	G2 box; other site
498216005329	G3 box; other site
498216005330	Switch II region; other site
498216005331	G4 box; other site
498216005332	G5 box; other site
498216005333	Nucleoside recognition; Region: Gate; pfam07670
498216005334	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
498216005335	Nucleoside recognition; Region: Gate; pfam07670
498216005336	FeoA domain; Region: FeoA; pfam04023
498216005337	Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918
498216005338	yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840
498216005339	catalytic triad [active]
498216005340	catalytic triad [active]
498216005341	oxyanion hole [active]
498216005342	biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244
498216005343	NADH(P)-binding; Region: NAD_binding_10; pfam13460
498216005344	NAD binding site [chemical binding]; other site
498216005345	substrate binding site [chemical binding]; other site
498216005346	putative active site [active]
498216005347	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
498216005348	Domain of unknown function (DUF4330); Region: DUF4330; pfam14221
498216005349	seryl-tRNA synthetase; Provisional; Region: PRK05431
498216005350	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
498216005351	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
498216005352	dimer interface [polypeptide binding]; other site
498216005353	active site
498216005354	motif 1; other site
498216005355	motif 2; other site
498216005356	motif 3; other site
498216005357	Mga helix-turn-helix domain; Region: Mga; pfam05043
498216005358	Mga helix-turn-helix domain; Region: Mga; pfam05043
498216005359	lysine transporter; Provisional; Region: PRK10836
498216005360	Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306
498216005361	acetolactate synthase; Reviewed; Region: PRK08617
498216005362	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
498216005363	PYR/PP interface [polypeptide binding]; other site
498216005364	dimer interface [polypeptide binding]; other site
498216005365	TPP binding site [chemical binding]; other site
498216005366	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
498216005367	Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010
498216005368	TPP-binding site [chemical binding]; other site
498216005369	dimer interface [polypeptide binding]; other site
498216005370	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
498216005371	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
498216005372	Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030
498216005373	Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797
498216005374	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
498216005375	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
498216005376	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
498216005377	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
498216005378	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
498216005379	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
498216005380	active site
498216005381	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
498216005382	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
498216005383	ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; cl00768
498216005384	Transcriptional regulators [Transcription]; Region: GntR; COG1802
498216005385	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
498216005386	DNA-binding site [nucleotide binding]; DNA binding site
498216005387	FCD domain; Region: FCD; pfam07729
498216005388	oxaloacetate decarboxylase; Provisional; Region: PRK12331
498216005389	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
498216005390	active site
498216005391	catalytic residues [active]
498216005392	metal binding site [ion binding]; metal-binding site
498216005393	homodimer binding site [polypeptide binding]; other site
498216005394	2'-(5''-triphosphoribosyl)-3'- dephospho-CoA:apo-citrate lyase; Reviewed; Region: citX; PRK01392
498216005395	Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051
498216005396	Coenzyme A transferase; Region: CoA_trans; cl17247
498216005397	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
498216005398	HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231
498216005399	citrate lyase subunit gamma; Provisional; Region: PRK13253
498216005400	[citrate (pro-3S)-lyase] ligase; Region: cit_ly_ligase; TIGR00124
498216005401	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
498216005402	active site
498216005403	nucleotide binding site [chemical binding]; other site
498216005404	HIGH motif; other site
498216005405	KMSKS motif; other site
498216005406	Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunit [Energy production and conversion]; Region: OadB; COG1883
498216005407	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06549
498216005408	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
498216005409	carboxyltransferase (CT) interaction site; other site
498216005410	biotinylation site [posttranslational modification]; other site
498216005411	H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851
498216005412	Citrate transporter; Region: CitMHS; pfam03600
498216005413	RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859
498216005414	RNA 2'-phosphotransferase, Tpt1 / KptA family; Region: PTS_2-RNA; pfam01885
498216005415	Histone acetyltransferase HPA2 and related acetyltransferases [Transcription / General function prediction only]; Region: WecD; COG0454
498216005416	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
498216005417	Coenzyme A binding pocket [chemical binding]; other site
498216005418	Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085
498216005419	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807
498216005420	Predicted transcriptional regulators [Transcription]; Region: COG1695
498216005421	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
498216005422	Cytochrome C biogenesis protein; Region: CcmH; cl01179
498216005423	This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146
498216005424	dimer interface [polypeptide binding]; other site
498216005425	FMN binding site [chemical binding]; other site
498216005426	NADPH bind site [chemical binding]; other site
498216005427	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
498216005428	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
498216005429	Walker A/P-loop; other site
498216005430	ATP binding site [chemical binding]; other site
498216005431	Q-loop/lid; other site
498216005432	ABC transporter signature motif; other site
498216005433	Walker B; other site
498216005434	D-loop; other site
498216005435	H-loop/switch region; other site
498216005436	Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559
498216005437	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
498216005438	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
498216005439	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
498216005440	Major Facilitator Superfamily; Region: MFS_1; pfam07690
498216005441	putative substrate translocation pore; other site
498216005442	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
498216005443	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
498216005444	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
498216005445	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
498216005446	non-specific DNA binding site [nucleotide binding]; other site
498216005447	salt bridge; other site
498216005448	sequence-specific DNA binding site [nucleotide binding]; other site
498216005449	Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028
498216005450	Predicted transcriptional regulators [Transcription]; Region: COG1725
498216005451	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
498216005452	DNA-binding site [nucleotide binding]; DNA binding site
498216005453	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
498216005454	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
498216005455	Walker A/P-loop; other site
498216005456	ATP binding site [chemical binding]; other site
498216005457	Q-loop/lid; other site
498216005458	ABC transporter signature motif; other site
498216005459	Walker B; other site
498216005460	D-loop; other site
498216005461	H-loop/switch region; other site
498216005462	Herpesvirus latent membrane protein 1 (LMP1); Region: Herpes_LMP1; pfam05297
498216005463	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
498216005464	Homeodomain-like domain; Region: HTH_23; pfam13384
498216005465	Transposase; Region: DDE_Tnp_ISL3; pfam01610
498216005466	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
498216005467	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
498216005468	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
498216005469	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
498216005470	Walker A/P-loop; other site
498216005471	ATP binding site [chemical binding]; other site
498216005472	Q-loop/lid; other site
498216005473	ABC transporter signature motif; other site
498216005474	Walker B; other site
498216005475	D-loop; other site
498216005476	H-loop/switch region; other site
498216005477	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
498216005478	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
498216005479	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
498216005480	Walker A/P-loop; other site
498216005481	ATP binding site [chemical binding]; other site
498216005482	Q-loop/lid; other site
498216005483	ABC transporter signature motif; other site
498216005484	Walker B; other site
498216005485	D-loop; other site
498216005486	H-loop/switch region; other site
498216005487	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
498216005488	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
498216005489	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
498216005490	dimer interface [polypeptide binding]; other site
498216005491	conserved gate region; other site
498216005492	putative PBP binding loops; other site
498216005493	ABC-ATPase subunit interface; other site
498216005494	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
498216005495	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
498216005496	dimer interface [polypeptide binding]; other site
498216005497	conserved gate region; other site
498216005498	putative PBP binding loops; other site
498216005499	ABC-ATPase subunit interface; other site
498216005500	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
498216005501	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
498216005502	peptide binding site [polypeptide binding]; other site
498216005503	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
498216005504	Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141
498216005505	potential catalytic triad [active]
498216005506	conserved cys residue [active]
498216005507	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
498216005508	putative DNA binding site [nucleotide binding]; other site
498216005509	putative Zn2+ binding site [ion binding]; other site
498216005510	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
498216005511	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
498216005512	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
498216005513	Walker A/P-loop; other site
498216005514	ATP binding site [chemical binding]; other site
498216005515	Q-loop/lid; other site
498216005516	ABC transporter signature motif; other site
498216005517	Walker B; other site
498216005518	D-loop; other site
498216005519	H-loop/switch region; other site
498216005520	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
498216005521	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
498216005522	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
498216005523	Walker A/P-loop; other site
498216005524	ATP binding site [chemical binding]; other site
498216005525	Q-loop/lid; other site
498216005526	ABC transporter signature motif; other site
498216005527	Walker B; other site
498216005528	D-loop; other site
498216005529	H-loop/switch region; other site
498216005530	Phosphotransferase enzyme family; Region: APH; pfam01636
498216005531	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
498216005532	active site
498216005533	substrate binding site [chemical binding]; other site
498216005534	ATP binding site [chemical binding]; other site
498216005535	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
498216005536	non-specific DNA binding site [nucleotide binding]; other site
498216005537	salt bridge; other site
498216005538	sequence-specific DNA binding site [nucleotide binding]; other site
498216005539	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
498216005540	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
498216005541	active site
498216005542	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
498216005543	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
498216005544	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
498216005545	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
498216005546	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
498216005547	non-specific DNA binding site [nucleotide binding]; other site
498216005548	salt bridge; other site
498216005549	sequence-specific DNA binding site [nucleotide binding]; other site
498216005550	Catalytic domain of Protein Kinases; Region: PKc; cd00180
498216005551	active site
498216005552	ATP binding site [chemical binding]; other site
498216005553	substrate binding site [chemical binding]; other site
498216005554	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
498216005555	substrate binding site [chemical binding]; other site
498216005556	activation loop (A-loop); other site
498216005557	activation loop (A-loop); other site
498216005558	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
498216005559	putative active site [active]
498216005560	putative NTP binding site [chemical binding]; other site
498216005561	putative nucleic acid binding site [nucleotide binding]; other site
498216005562	GMP synthase; Reviewed; Region: guaA; PRK00074
498216005563	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
498216005564	AMP/PPi binding site [chemical binding]; other site
498216005565	candidate oxyanion hole; other site
498216005566	catalytic triad [active]
498216005567	potential glutamine specificity residues [chemical binding]; other site
498216005568	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
498216005569	ATP Binding subdomain [chemical binding]; other site
498216005570	Dimerization subdomain; other site
498216005571	pantothenate kinase; Provisional; Region: PRK05439
498216005572	Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025
498216005573	ATP-binding site [chemical binding]; other site
498216005574	CoA-binding site [chemical binding]; other site
498216005575	Mg2+-binding site [ion binding]; other site
498216005576	Peptidase family C69; Region: Peptidase_C69; pfam03577
498216005577	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
498216005578	Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973
498216005579	Part of AAA domain; Region: AAA_19; pfam13245
498216005580	Family description; Region: UvrD_C_2; pfam13538
498216005581	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
498216005582	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
498216005583	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
498216005584	TrkA-C domain; Region: TrkA_C; pfam02080
498216005585	proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250
498216005586	manganese transport protein MntH; Reviewed; Region: PRK00701
498216005587	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
498216005588	Ferrochelatase; Region: Ferrochelatase; pfam00762
498216005589	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
498216005590	C-terminal domain interface [polypeptide binding]; other site
498216005591	active site
498216005592	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
498216005593	active site
498216005594	N-terminal domain interface [polypeptide binding]; other site
498216005595	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
498216005596	catalytic core [active]
498216005597	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
498216005598	FtsX-like permease family; Region: FtsX; pfam02687
498216005599	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
498216005600	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
498216005601	Walker A/P-loop; other site
498216005602	ATP binding site [chemical binding]; other site
498216005603	Q-loop/lid; other site
498216005604	ABC transporter signature motif; other site
498216005605	Walker B; other site
498216005606	D-loop; other site
498216005607	H-loop/switch region; other site
498216005608	Amino acid permease; Region: AA_permease_2; pfam13520
498216005609	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
498216005610	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
498216005611	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
498216005612	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
498216005613	HflX GTPase family; Region: HflX; cd01878
498216005614	G1 box; other site
498216005615	GTP/Mg2+ binding site [chemical binding]; other site
498216005616	Switch I region; other site
498216005617	G2 box; other site
498216005618	G3 box; other site
498216005619	Switch II region; other site
498216005620	G4 box; other site
498216005621	G5 box; other site
498216005622	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
498216005623	Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944
498216005624	NodB motif; other site
498216005625	active site
498216005626	catalytic site [active]
498216005627	Zn binding site [ion binding]; other site
498216005628	Sulfatase; Region: Sulfatase; cl17466
498216005629	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
498216005630	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
498216005631	Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944
498216005632	Chain length determinant protein; Region: Wzz; cl15801
498216005633	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
498216005634	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
498216005635	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
498216005636	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
498216005637	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
498216005638	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
498216005639	active site
498216005640	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
498216005641	Homeodomain-like domain; Region: HTH_23; pfam13384
498216005642	Transposase; Region: DDE_Tnp_ISL3; pfam01610
498216005643	Domain of unknown function (DUF3367); Region: DUF3367; pfam11847
498216005644	Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448
498216005645	Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183
498216005646	active site
498216005647	SH3-like domain; Region: SH3_8; pfam13457
498216005648	SH3-like domain; Region: SH3_8; pfam13457
498216005649	SH3-like domain; Region: SH3_8; pfam13457
498216005650	SH3-like domain; Region: SH3_8; pfam13457
498216005651	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
498216005652	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
498216005653	UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
498216005654	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
498216005655	active site
498216005656	homodimer interface [polypeptide binding]; other site
498216005657	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
498216005658	Bacterial sugar transferase; Region: Bac_transf; pfam02397
498216005659	Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488
498216005660	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
498216005661	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
498216005662	active site
498216005663	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
498216005664	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
498216005665	NAD(P) binding site [chemical binding]; other site
498216005666	active site
498216005667	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
498216005668	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
498216005669	dimer interface [polypeptide binding]; other site
498216005670	conserved gate region; other site
498216005671	putative PBP binding loops; other site
498216005672	ABC-ATPase subunit interface; other site
498216005673	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
498216005674	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
498216005675	dimer interface [polypeptide binding]; other site
498216005676	conserved gate region; other site
498216005677	putative PBP binding loops; other site
498216005678	ABC-ATPase subunit interface; other site
498216005679	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
498216005680	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
498216005681	substrate binding pocket [chemical binding]; other site
498216005682	membrane-bound complex binding site; other site
498216005683	hinge residues; other site
498216005684	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
498216005685	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
498216005686	Walker A/P-loop; other site
498216005687	ATP binding site [chemical binding]; other site
498216005688	Q-loop/lid; other site
498216005689	ABC transporter signature motif; other site
498216005690	Walker B; other site
498216005691	D-loop; other site
498216005692	H-loop/switch region; other site
498216005693	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
498216005694	metal binding site 2 [ion binding]; metal-binding site
498216005695	putative DNA binding helix; other site
498216005696	metal binding site 1 [ion binding]; metal-binding site
498216005697	dimer interface [polypeptide binding]; other site
498216005698	structural Zn2+ binding site [ion binding]; other site
498216005699	Guanylate kinase; Region: Guanylate_kin; pfam00625
498216005700	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
498216005701	active site
498216005702	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
498216005703	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
498216005704	Coenzyme A binding pocket [chemical binding]; other site
498216005705	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883
498216005706	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
498216005707	NlpC/P60 family; Region: NLPC_P60; pfam00877
498216005708	tyrosyl-tRNA synthetase; Provisional; Region: PRK13354
498216005709	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
498216005710	active site
498216005711	HIGH motif; other site
498216005712	dimer interface [polypeptide binding]; other site
498216005713	KMSKS motif; other site
498216005714	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
498216005715	RNA binding surface [nucleotide binding]; other site
498216005716	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
498216005717	cation diffusion facilitator family transporter; Region: CDF; TIGR01297
498216005718	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
498216005719	dimerization interface [polypeptide binding]; other site
498216005720	putative DNA binding site [nucleotide binding]; other site
498216005721	putative Zn2+ binding site [ion binding]; other site
498216005722	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
498216005723	ApbE family; Region: ApbE; pfam02424
498216005724	Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101
498216005725	Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338
498216005726	active site
498216005727	homodimer interface [polypeptide binding]; other site
498216005728	catalytic site [active]
498216005729	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
498216005730	homodimer interface [polypeptide binding]; other site
498216005731	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
498216005732	active site pocket [active]
498216005733	glycogen synthase; Provisional; Region: glgA; PRK00654
498216005734	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
498216005735	ADP-binding pocket [chemical binding]; other site
498216005736	homodimer interface [polypeptide binding]; other site
498216005737	glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092
498216005738	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
498216005739	active site
498216005740	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
498216005741	dimer interface [polypeptide binding]; other site
498216005742	N-terminal domain interface [polypeptide binding]; other site
498216005743	sulfate 1 binding site; other site
498216005744	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293
498216005745	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
498216005746	ligand binding site; other site
498216005747	oligomer interface; other site
498216005748	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
498216005749	dimer interface [polypeptide binding]; other site
498216005750	N-terminal domain interface [polypeptide binding]; other site
498216005751	sulfate 1 binding site; other site
498216005752	glycogen branching enzyme; Provisional; Region: PRK12313
498216005753	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
498216005754	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
498216005755	active site
498216005756	catalytic site [active]
498216005757	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
498216005758	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
498216005759	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
498216005760	homodimer interface [polypeptide binding]; other site
498216005761	substrate-cofactor binding pocket; other site
498216005762	catalytic residue [active]
498216005763	Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098
498216005764	Uncharacterized conserved protein [Function unknown]; Region: COG1284
498216005765	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
498216005766	Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874
498216005767	Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032
498216005768	ArsC family; Region: ArsC; pfam03960
498216005769	putative catalytic residues [active]
498216005770	thiol/disulfide switch; other site
498216005771	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
498216005772	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
498216005773	Walker A motif; other site
498216005774	ATP binding site [chemical binding]; other site
498216005775	Walker B motif; other site
498216005776	arginine finger; other site
498216005777	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
498216005778	Walker A motif; other site
498216005779	ATP binding site [chemical binding]; other site
498216005780	Walker B motif; other site
498216005781	arginine finger; other site
498216005782	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
498216005783	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
498216005784	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
498216005785	NADP binding site [chemical binding]; other site
498216005786	active site
498216005787	putative substrate binding site [chemical binding]; other site
498216005788	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
498216005789	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
498216005790	NAD binding site [chemical binding]; other site
498216005791	substrate binding site [chemical binding]; other site
498216005792	homodimer interface [polypeptide binding]; other site
498216005793	active site
498216005794	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405
498216005795	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
498216005796	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
498216005797	substrate binding site; other site
498216005798	tetramer interface; other site
498216005799	Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464
498216005800	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581
498216005801	Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542
498216005802	Homeodomain-like domain; Region: HTH_23; pfam13384
498216005803	Transposase; Region: DDE_Tnp_ISL3; pfam01610
498216005804	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
498216005805	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
498216005806	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
498216005807	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
498216005808	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
498216005809	Bacterial sugar transferase; Region: Bac_transf; pfam02397
498216005810	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
498216005811	Helix-turn-helix domain; Region: HTH_38; pfam13936
498216005812	Integrase core domain; Region: rve; pfam00665
498216005813	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
498216005814	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
498216005815	active site
498216005816	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
498216005817	Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128
498216005818	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
498216005819	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
498216005820	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
498216005821	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
498216005822	active site
498216005823	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
498216005824	LicD family; Region: LicD; pfam04991
498216005825	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
498216005826	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
498216005827	trimer interface [polypeptide binding]; other site
498216005828	active site
498216005829	substrate binding site [chemical binding]; other site
498216005830	CoA binding site [chemical binding]; other site
498216005831	Capsular polysaccharide synthesis protein; Region: Caps_synth; pfam05704
498216005832	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_6; cd04955
498216005833	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
498216005834	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
498216005835	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
498216005836	Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944
498216005837	Chain length determinant protein; Region: Wzz; cl15801
498216005838	yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840
498216005839	catalytic triad [active]
498216005840	catalytic triad [active]
498216005841	oxyanion hole [active]
498216005842	QueT transporter; Region: QueT; pfam06177
498216005843	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK06550
498216005844	classical (c) SDRs; Region: SDR_c; cd05233
498216005845	NAD(P) binding site [chemical binding]; other site
498216005846	active site
498216005847	Protein of unknown function (DUF2829); Region: DUF2829; pfam11195
498216005848	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
498216005849	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
498216005850	non-specific DNA binding site [nucleotide binding]; other site
498216005851	salt bridge; other site
498216005852	sequence-specific DNA binding site [nucleotide binding]; other site
498216005853	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
498216005854	catalytic core [active]
498216005855	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
498216005856	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
498216005857	Walker A/P-loop; other site
498216005858	ATP binding site [chemical binding]; other site
498216005859	Q-loop/lid; other site
498216005860	ABC transporter signature motif; other site
498216005861	Walker B; other site
498216005862	D-loop; other site
498216005863	H-loop/switch region; other site
498216005864	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
498216005865	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
498216005866	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
498216005867	Walker A/P-loop; other site
498216005868	ATP binding site [chemical binding]; other site
498216005869	Q-loop/lid; other site
498216005870	ABC transporter signature motif; other site
498216005871	Walker B; other site
498216005872	D-loop; other site
498216005873	H-loop/switch region; other site
498216005874	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
498216005875	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
498216005876	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
498216005877	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
498216005878	dimer interface [polypeptide binding]; other site
498216005879	conserved gate region; other site
498216005880	putative PBP binding loops; other site
498216005881	ABC-ATPase subunit interface; other site
498216005882	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
498216005883	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
498216005884	dimer interface [polypeptide binding]; other site
498216005885	conserved gate region; other site
498216005886	putative PBP binding loops; other site
498216005887	ABC-ATPase subunit interface; other site
498216005888	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
498216005889	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
498216005890	peptide binding site [polypeptide binding]; other site
498216005891	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
498216005892	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
498216005893	putative substrate translocation pore; other site
498216005894	elongation factor P; Validated; Region: PRK00529
498216005895	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
498216005896	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
498216005897	RNA binding site [nucleotide binding]; other site
498216005898	Elongation factor P, C-terminal; Region: Elong-fact-P_C; pfam09285
498216005899	RNA binding site [nucleotide binding]; other site
498216005900	Uncharacterized conserved protein [Function unknown]; Region: COG1556
498216005901	Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139
498216005902	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
498216005903	4Fe-4S binding domain; Region: Fer4; pfam00037
498216005904	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
498216005905	Cysteine-rich domain; Region: CCG; pfam02754
498216005906	Cysteine-rich domain; Region: CCG; pfam02754
498216005907	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
498216005908	active site
498216005909	methionine cluster; other site
498216005910	phosphorylation site [posttranslational modification]
498216005911	metal binding site [ion binding]; metal-binding site
498216005912	potential frameshift: common BLAST hit: gi|258509070|ref|YP_003171821.1| outer surface protein
498216005913	Uncharacterized conserved protein [Function unknown]; Region: COG3589
498216005914	Uncharacterized conserved protein [Function unknown]; Region: COG3589
498216005915	Domain of unknown function (DUF3284); Region: DUF3284; pfam11687
498216005916	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
498216005917	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
498216005918	Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345
498216005919	Melibiase; Region: Melibiase; pfam02065
498216005920	hypothetical protein; Validated; Region: PRK02101
498216005921	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
498216005922	DNA binding residues [nucleotide binding]
498216005923	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
498216005924	Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; pfam09860
498216005925	helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448
498216005926	AAA domain; Region: AAA_30; pfam13604
498216005927	Family description; Region: UvrD_C_2; pfam13538
498216005928	WxL domain surface cell wall-binding; Region: WxL; pfam13731
498216005929	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
498216005930	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
498216005931	substrate binding site [chemical binding]; other site
498216005932	ATP binding site [chemical binding]; other site
498216005933	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968
498216005934	conserved hypothetical protein; Region: Lon_rel_chp; TIGR02653
498216005935	Putative ATP-dependent Lon protease; Region: Lon_2; pfam13337
498216005936	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
498216005937	TIGR02687 family protein; Region: TIGR02687
498216005938	PglZ domain; Region: PglZ; pfam08665
498216005939	Methyltransferase domain; Region: Methyltransf_26; pfam13659
498216005940	Eco57I restriction-modification methylase; Region: Eco57I; pfam07669
498216005941	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
498216005942	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
498216005943	Int/Topo IB signature motif; other site
498216005944	Domain of unknown function (DUF1788); Region: DUF1788; pfam08747
498216005945	Putative inner membrane protein (DUF1819); Region: DUF1819; pfam08849
498216005946	Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877
498216005947	Protein of unknown function (DUF998); Region: DUF998; pfam06197
498216005948	PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996
498216005949	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
498216005950	active site turn [active]
498216005951	phosphorylation site [posttranslational modification]
498216005952	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
498216005953	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
498216005954	HPr interaction site; other site
498216005955	glycerol kinase (GK) interaction site [polypeptide binding]; other site
498216005956	active site
498216005957	phosphorylation site [posttranslational modification]
498216005958	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
498216005959	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
498216005960	Ca binding site [ion binding]; other site
498216005961	active site
498216005962	catalytic site [active]
498216005963	Transcriptional regulators [Transcription]; Region: PurR; COG1609
498216005964	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
498216005965	DNA binding site [nucleotide binding]
498216005966	domain linker motif; other site
498216005967	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
498216005968	sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322
498216005969	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
498216005970	substrate binding [chemical binding]; other site
498216005971	active site
498216005972	Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244
498216005973	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
498216005974	triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269
498216005975	NADP binding site [chemical binding]; other site
498216005976	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
498216005977	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
498216005978	S-adenosylmethionine binding site [chemical binding]; other site
498216005979	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
498216005980	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
498216005981	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
498216005982	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
498216005983	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
498216005984	ATP-grasp domain; Region: ATP-grasp_4; cl17255
498216005985	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
498216005986	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
498216005987	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
498216005988	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
498216005989	carboxyltransferase (CT) interaction site; other site
498216005990	biotinylation site [posttranslational modification]; other site
498216005991	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
498216005992	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
498216005993	dimer interface [polypeptide binding]; other site
498216005994	active site
498216005995	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
498216005996	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
498216005997	NAD(P) binding site [chemical binding]; other site
498216005998	homotetramer interface [polypeptide binding]; other site
498216005999	homodimer interface [polypeptide binding]; other site
498216006000	active site
498216006001	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
498216006002	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
498216006003	putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151
498216006004	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
498216006005	FMN binding site [chemical binding]; other site
498216006006	substrate binding site [chemical binding]; other site
498216006007	putative catalytic residue [active]
498216006008	acyl carrier protein; Provisional; Region: acpP; PRK00982
498216006009	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
498216006010	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
498216006011	dimer interface [polypeptide binding]; other site
498216006012	active site
498216006013	CoA binding pocket [chemical binding]; other site
498216006014	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
498216006015	MarR family; Region: MarR_2; pfam12802
498216006016	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
498216006017	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
498216006018	Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979
498216006019	Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187
498216006020	dimer interface [polypeptide binding]; other site
498216006021	active site
498216006022	metal binding site [ion binding]; metal-binding site
498216006023	Uncharacterized protein conserved in bacteria (DUF2316); Region: DUF2316; pfam10078
498216006024	Transcriptional regulators [Transcription]; Region: MarR; COG1846
498216006025	MarR family; Region: MarR_2; pfam12802
498216006026	zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240
498216006027	S-formylglutathione hydrolase; Region: PLN02442
498216006028	Putative esterase; Region: Esterase; pfam00756
498216006029	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
498216006030	Double zinc ribbon; Region: DZR; pfam12773
498216006031	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
498216006032	putative DNA binding site [nucleotide binding]; other site
498216006033	putative Zn2+ binding site [ion binding]; other site
498216006034	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
498216006035	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
498216006036	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
498216006037	Walker A/P-loop; other site
498216006038	ATP binding site [chemical binding]; other site
498216006039	Q-loop/lid; other site
498216006040	ABC transporter signature motif; other site
498216006041	Walker B; other site
498216006042	D-loop; other site
498216006043	H-loop/switch region; other site
498216006044	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677
498216006045	nudix motif; other site
498216006046	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
498216006047	catalytic core [active]
498216006048	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
498216006049	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
498216006050	Double zinc ribbon; Region: DZR; pfam12773
498216006051	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
498216006052	Beta-lactamase; Region: Beta-lactamase; pfam00144
498216006053	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
498216006054	Domain of unknown function DUF20; Region: UPF0118; pfam01594
498216006055	Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165
498216006056	active site
498216006057	catalytic site [active]
498216006058	Predicted membrane protein [Function unknown]; Region: COG2246
498216006059	GtrA-like protein; Region: GtrA; pfam04138
498216006060	lipid kinase, YegS/Rv2252/BmrU family; Region: TIGR00147
498216006061	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
498216006062	Diacylglycerol kinase accessory domain; Region: DAGK_acc; cl02440
498216006063	pyruvate oxidase; Region: pyruv_oxi_spxB; TIGR02720
498216006064	Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410
498216006065	PYR/PP interface [polypeptide binding]; other site
498216006066	dimer interface [polypeptide binding]; other site
498216006067	TPP binding site [chemical binding]; other site
498216006068	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
498216006069	Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014
498216006070	TPP-binding site [chemical binding]; other site
498216006071	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891
498216006072	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
498216006073	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
498216006074	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
498216006075	dimer interface [polypeptide binding]; other site
498216006076	conserved gate region; other site
498216006077	putative PBP binding loops; other site
498216006078	ABC-ATPase subunit interface; other site
498216006079	ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175
498216006080	ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294
498216006081	Walker A/P-loop; other site
498216006082	ATP binding site [chemical binding]; other site
498216006083	Q-loop/lid; other site
498216006084	ABC transporter signature motif; other site
498216006085	Walker B; other site
498216006086	D-loop; other site
498216006087	H-loop/switch region; other site
498216006088	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
498216006089	DNA-binding protein, stimulates sugar fermentation [General function prediction only]; Region: SfsA; COG1489
498216006090	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
498216006091	Ligand Binding Site [chemical binding]; other site
498216006092	Predicted ATP-grasp enzyme [General function prediction only]; Region: COG3919
498216006093	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
498216006094	homoserine kinase; Provisional; Region: PRK01212
498216006095	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
498216006096	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
498216006097	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560
498216006098	pyridoxal 5'-phosphate binding site [chemical binding]; other site
498216006099	catalytic residue [active]
498216006100	Homoserine dehydrogenase [Amino acid transport and metabolism]; Region: ThrA; COG0460
498216006101	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
498216006102	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
498216006103	aspartate kinase; Reviewed; Region: PRK09034
498216006104	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
498216006105	nucleotide binding site [chemical binding]; other site
498216006106	substrate binding site [chemical binding]; other site
498216006107	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
498216006108	Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  These two proteins are lipid raft-associated.  Individual proteins of...; Region: Band_7_flotillin; cd03399
498216006109	lysyl-tRNA synthetase; Reviewed; Region: lysK; PRK00750
498216006110	Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641
498216006111	Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303
498216006112	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
498216006113	D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186
498216006114	homodimer interface [polypeptide binding]; other site
498216006115	ligand binding site [chemical binding]; other site
498216006116	NAD binding site [chemical binding]; other site
498216006117	catalytic site [active]
498216006118	aromatic amino acid aminotransferase; Validated; Region: PRK07309
498216006119	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
498216006120	pyridoxal 5'-phosphate binding site [chemical binding]; other site
498216006121	homodimer interface [polypeptide binding]; other site
498216006122	catalytic residue [active]
498216006123	Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987
498216006124	Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537
498216006125	nucleotide binding site/active site [active]
498216006126	HIT family signature motif; other site
498216006127	catalytic residue [active]
498216006128	Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367
498216006129	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
498216006130	active site
498216006131	dimer interface [polypeptide binding]; other site
498216006132	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
498216006133	Ligand Binding Site [chemical binding]; other site
498216006134	Molecular Tunnel; other site
498216006135	Predicted integral membrane protein [Function unknown]; Region: COG0392
498216006136	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
498216006137	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
498216006138	active site
498216006139	metal binding site [ion binding]; metal-binding site
498216006140	1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080
498216006141	UbiA prenyltransferase family; Region: UbiA; pfam01040
498216006142	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
498216006143	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
498216006144	substrate binding pocket [chemical binding]; other site
498216006145	chain length determination region; other site
498216006146	substrate-Mg2+ binding site; other site
498216006147	catalytic residues [active]
498216006148	aspartate-rich region 1; other site
498216006149	active site lid residues [active]
498216006150	aspartate-rich region 2; other site
498216006151	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
498216006152	propionate/acetate kinase; Provisional; Region: PRK12379
498216006153	putative transposase OrfB; Reviewed; Region: PHA02517
498216006154	HTH-like domain; Region: HTH_21; pfam13276
498216006155	Integrase core domain; Region: rve; pfam00665
498216006156	Integrase core domain; Region: rve_2; pfam13333
498216006157	Helix-turn-helix domain; Region: HTH_28; pfam13518
498216006158	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
498216006159	Transposase; Region: HTH_Tnp_1; pfam01527
498216006160	Helix-turn-helix domain; Region: HTH_28; pfam13518
498216006161	Winged helix-turn helix; Region: HTH_29; pfam13551
498216006162	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152
498216006163	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
498216006164	Walker A/P-loop; other site
498216006165	ATP binding site [chemical binding]; other site
498216006166	Q-loop/lid; other site
498216006167	ABC transporter signature motif; other site
498216006168	Walker B; other site
498216006169	D-loop; other site
498216006170	H-loop/switch region; other site
498216006171	Domain of unknown function (DUF4162); Region: DUF4162; pfam13732
498216006172	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
498216006173	Predicted transcriptional regulators [Transcription]; Region: COG1725
498216006174	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
498216006175	DNA-binding site [nucleotide binding]; DNA binding site
498216006176	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
498216006177	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
498216006178	Walker A/P-loop; other site
498216006179	ATP binding site [chemical binding]; other site
498216006180	Q-loop/lid; other site
498216006181	ABC transporter signature motif; other site
498216006182	Walker B; other site
498216006183	D-loop; other site
498216006184	H-loop/switch region; other site
498216006185	ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346
498216006186	glucose-1-dehydrogenase; Provisional; Region: PRK08936
498216006187	glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358
498216006188	NAD binding site [chemical binding]; other site
498216006189	homodimer interface [polypeptide binding]; other site
498216006190	active site
498216006191	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
498216006192	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
498216006193	hexamer interface [polypeptide binding]; other site
498216006194	ligand binding site [chemical binding]; other site
498216006195	putative active site [active]
498216006196	NAD(P) binding site [chemical binding]; other site
498216006197	Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171
498216006198	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
498216006199	tetramer interface [polypeptide binding]; other site
498216006200	pyridoxal 5'-phosphate binding site [chemical binding]; other site
498216006201	catalytic residue [active]
498216006202	OPT oligopeptide transporter protein; Region: OPT; cl14607
498216006203	OPT oligopeptide transporter protein; Region: OPT; cl14607
498216006204	Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126
498216006205	Peptidase family C69; Region: Peptidase_C69; pfam03577
498216006206	Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249
498216006207	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
498216006208	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
498216006209	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
498216006210	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
498216006211	Major Facilitator Superfamily; Region: MFS_1; pfam07690
498216006212	putative substrate translocation pore; other site
498216006213	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
498216006214	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
498216006215	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
498216006216	beta-galactosidase; Region: BGL; TIGR03356
498216006217	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
498216006218	PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995
498216006219	active site turn [active]
498216006220	phosphorylation site [posttranslational modification]
498216006221	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
498216006222	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162
498216006223	HPr interaction site; other site
498216006224	glycerol kinase (GK) interaction site [polypeptide binding]; other site
498216006225	active site
498216006226	phosphorylation site [posttranslational modification]
498216006227	transcriptional antiterminator BglG; Provisional; Region: PRK09772
498216006228	CAT RNA binding domain; Region: CAT_RBD; smart01061
498216006229	PRD domain; Region: PRD; pfam00874
498216006230	PRD domain; Region: PRD; pfam00874
498216006231	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
498216006232	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
498216006233	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
498216006234	Walker A/P-loop; other site
498216006235	ATP binding site [chemical binding]; other site
498216006236	Q-loop/lid; other site
498216006237	ABC transporter signature motif; other site
498216006238	Walker B; other site
498216006239	D-loop; other site
498216006240	H-loop/switch region; other site
498216006241	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
498216006242	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
498216006243	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
498216006244	Walker A/P-loop; other site
498216006245	ATP binding site [chemical binding]; other site
498216006246	Q-loop/lid; other site
498216006247	ABC transporter signature motif; other site
498216006248	Walker B; other site
498216006249	D-loop; other site
498216006250	H-loop/switch region; other site
498216006251	Listerrria innocua Lin0431  is similar to the N-Utilization Substance G (NusG) N terminal (NGN) insert (DII); Region: Lin0431_like; cd09911
498216006252	trimer interface [polypeptide binding]; other site
498216006253	CRISPR/Cas system-associated protein Csn2; Region: Csn2; cd12218
498216006254	CRISPR type II-A/NMEMI-associated protein Csn2; Region: cas_Csn2; TIGR01866
498216006255	tetramer interface [polypeptide binding]; other site
498216006256	putative DNA binding site [nucleotide binding]; other site
498216006257	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09638
498216006258	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656
498216006259	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083
498216006260	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083
498216006261	Protein of unknown function (DUF1093); Region: DUF1093; pfam06486
498216006262	ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987
498216006263	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
498216006264	ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247
498216006265	Walker A/P-loop; other site
498216006266	ATP binding site [chemical binding]; other site
498216006267	Q-loop/lid; other site
498216006268	ABC transporter signature motif; other site
498216006269	Walker B; other site
498216006270	D-loop; other site
498216006271	H-loop/switch region; other site
498216006272	ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988
498216006273	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
498216006274	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
498216006275	Walker A/P-loop; other site
498216006276	ATP binding site [chemical binding]; other site
498216006277	Q-loop/lid; other site
498216006278	ABC transporter signature motif; other site
498216006279	Walker B; other site
498216006280	D-loop; other site
498216006281	H-loop/switch region; other site
498216006282	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
498216006283	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
498216006284	cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097
498216006285	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
498216006286	thymidine phosphorylase; Reviewed; Region: deoA; PRK05820
498216006287	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
498216006288	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
498216006289	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941
498216006290	adenosine deaminase; Provisional; Region: PRK09358
498216006291	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
498216006292	active site
498216006293	Protein of unknown function (DUF460); Region: DUF460; pfam04312
498216006294	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
498216006295	EamA-like transporter family; Region: EamA; pfam00892
498216006296	EamA-like transporter family; Region: EamA; pfam00892
498216006297	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
498216006298	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
498216006299	Ligand Binding Site [chemical binding]; other site
498216006300	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
498216006301	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
498216006302	non-specific DNA binding site [nucleotide binding]; other site
498216006303	salt bridge; other site
498216006304	sequence-specific DNA binding site [nucleotide binding]; other site
498216006305	Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350
498216006306	Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348
498216006307	epoxyqueuosine reductase; Region: TIGR00276
498216006308	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
498216006309	Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cl02500
498216006310	protein binding surface [polypeptide binding]; other site
498216006311	HEAT repeats; Region: HEAT_2; pfam13646
498216006312	BioY family; Region: BioY; pfam02632
498216006313	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
498216006314	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
498216006315	DNA binding residues [nucleotide binding]
498216006316	putative dimer interface [polypeptide binding]; other site
498216006317	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
498216006318	formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287
498216006319	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
498216006320	catalytic Zn binding site [ion binding]; other site
498216006321	NAD(P) binding site [chemical binding]; other site
498216006322	structural Zn binding site [ion binding]; other site
498216006323	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
498216006324	NADH(P)-binding; Region: NAD_binding_10; pfam13460
498216006325	NAD(P) binding site [chemical binding]; other site
498216006326	active site
498216006327	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
498216006328	S-adenosylmethionine binding site [chemical binding]; other site
498216006329	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
498216006330	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
498216006331	catalytic triad [active]
498216006332	Uncharacterized protein conserved in bacteria (DUF2263); Region: DUF2263; pfam10021
498216006333	Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cl00019
498216006334	Domain of unknown function DUF21; Region: DUF21; pfam01595
498216006335	FOG: CBS domain [General function prediction only]; Region: COG0517
498216006336	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
498216006337	Transporter associated domain; Region: CorC_HlyC; smart01091
498216006338	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
498216006339	Major Facilitator Superfamily; Region: MFS_1; pfam07690
498216006340	Maf-like protein; Region: Maf; pfam02545
498216006341	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
498216006342	active site
498216006343	dimer interface [polypeptide binding]; other site
498216006344	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
498216006345	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
498216006346	ATP binding site [chemical binding]; other site
498216006347	Mg2+ binding site [ion binding]; other site
498216006348	G-X-G motif; other site
498216006349	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
498216006350	ATP binding site [chemical binding]; other site
498216006351	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
498216006352	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
498216006353	MutS domain I; Region: MutS_I; pfam01624
498216006354	MutS domain II; Region: MutS_II; pfam05188
498216006355	MutS domain III; Region: MutS_III; pfam05192
498216006356	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
498216006357	Walker A/P-loop; other site
498216006358	ATP binding site [chemical binding]; other site
498216006359	Q-loop/lid; other site
498216006360	ABC transporter signature motif; other site
498216006361	Walker B; other site
498216006362	D-loop; other site
498216006363	H-loop/switch region; other site
498216006364	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
498216006365	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
498216006366	putative active site [active]
498216006367	putative NTP binding site [chemical binding]; other site
498216006368	putative nucleic acid binding site [nucleotide binding]; other site
498216006369	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
498216006370	Amino acid permease; Region: AA_permease_2; pfam13520
498216006371	Domain of unknown function (DUF1827); Region: DUF1827; pfam08860
498216006372	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
498216006373	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
498216006374	ring oligomerisation interface [polypeptide binding]; other site
498216006375	ATP/Mg binding site [chemical binding]; other site
498216006376	stacking interactions; other site
498216006377	hinge regions; other site
498216006378	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
498216006379	oligomerisation interface [polypeptide binding]; other site
498216006380	mobile loop; other site
498216006381	roof hairpin; other site
498216006382	CAAX protease self-immunity; Region: Abi; pfam02517
498216006383	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581
498216006384	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
498216006385	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
498216006386	Walker A/P-loop; other site
498216006387	ATP binding site [chemical binding]; other site
498216006388	Q-loop/lid; other site
498216006389	ABC transporter signature motif; other site
498216006390	Walker B; other site
498216006391	D-loop; other site
498216006392	H-loop/switch region; other site
498216006393	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
498216006394	DNA-binding site [nucleotide binding]; DNA binding site
498216006395	redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472
498216006396	Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971
498216006397	CoA binding domain; Region: CoA_binding; pfam02629
498216006398	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
498216006399	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
498216006400	Walker A/P-loop; other site
498216006401	ATP binding site [chemical binding]; other site
498216006402	Q-loop/lid; other site
498216006403	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
498216006404	ABC transporter signature motif; other site
498216006405	Walker B; other site
498216006406	D-loop; other site
498216006407	ABC transporter; Region: ABC_tran_2; pfam12848
498216006408	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
498216006409	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
498216006410	active site
498216006411	P-loop; other site
498216006412	phosphorylation site [posttranslational modification]
498216006413	UGMP family protein; Validated; Region: PRK09604
498216006414	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
498216006415	Carbamoyltransferase; Region: CmcH_NodU; pfam02543
498216006416	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
498216006417	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
498216006418	Coenzyme A binding pocket [chemical binding]; other site
498216006419	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
498216006420	Glycoprotease family; Region: Peptidase_M22; pfam00814
498216006421	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
498216006422	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
498216006423	active site
498216006424	homotetramer interface [polypeptide binding]; other site
498216006425	homodimer interface [polypeptide binding]; other site
498216006426	Acyl-ACP thioesterase; Region: Acyl-ACP_TE; pfam01643
498216006427	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
498216006428	active site
498216006429	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
498216006430	active site 2 [active]
498216006431	active site 1 [active]
498216006432	Predicted methyltransferases [General function prediction only]; Region: COG0313
498216006433	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
498216006434	putative SAM binding site [chemical binding]; other site
498216006435	putative homodimer interface [polypeptide binding]; other site
498216006436	Protein of unknown function (DUF972); Region: DUF972; pfam06156
498216006437	DNA polymerase III subunit delta'; Validated; Region: PRK08058
498216006438	DNA polymerase III subunit delta'; Validated; Region: PRK08485
498216006439	Protein of unknown function (DUF970); Region: DUF970; pfam06153
498216006440	thymidylate kinase; Validated; Region: tmk; PRK00698
498216006441	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
498216006442	TMP-binding site; other site
498216006443	ATP-binding site [chemical binding]; other site
498216006444	Protein of unknown function (DUF2508); Region: DUF2508; pfam10704
498216006445	recombination protein RecR; Reviewed; Region: recR; PRK00076
498216006446	RecR protein; Region: RecR; pfam02132
498216006447	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
498216006448	putative active site [active]
498216006449	putative metal-binding site [ion binding]; other site
498216006450	tetramer interface [polypeptide binding]; other site
498216006451	hypothetical protein; Validated; Region: PRK00153
498216006452	DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563
498216006453	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
498216006454	Walker A motif; other site
498216006455	ATP binding site [chemical binding]; other site
498216006456	Walker B motif; other site
498216006457	arginine finger; other site
498216006458	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
498216006459	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
498216006460	nucleoside/Zn binding site; other site
498216006461	dimer interface [polypeptide binding]; other site
498216006462	catalytic motif [active]
498216006463	Methyltransferase domain; Region: Methyltransf_31; pfam13847
498216006464	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
498216006465	S-adenosylmethionine binding site [chemical binding]; other site
498216006466	Predicted integral membrane protein [Function unknown]; Region: COG0392
498216006467	Uncharacterized conserved protein [Function unknown]; Region: COG2898
498216006468	Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924
498216006469	Transcriptional regulators [Transcription]; Region: PurR; COG1609
498216006470	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
498216006471	DNA binding site [nucleotide binding]
498216006472	domain linker motif; other site
498216006473	Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286
498216006474	putative dimerization interface [polypeptide binding]; other site
498216006475	putative ligand binding site [chemical binding]; other site
498216006476	Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475
498216006477	putative active site [active]
498216006478	catalytic triad [active]
498216006479	PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238
498216006480	Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475
498216006481	PA/protease or protease-like domain interface [polypeptide binding]; other site
498216006482	Fn3-like domain (DUF1034); Region: DUF1034; pfam06280
498216006483	peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405
498216006484	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
498216006485	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
498216006486	core dimer interface [polypeptide binding]; other site
498216006487	peripheral dimer interface [polypeptide binding]; other site
498216006488	L10 interface [polypeptide binding]; other site
498216006489	L11 interface [polypeptide binding]; other site
498216006490	putative EF-Tu interaction site [polypeptide binding]; other site
498216006491	putative EF-G interaction site [polypeptide binding]; other site
498216006492	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
498216006493	23S rRNA interface [nucleotide binding]; other site
498216006494	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
498216006495	drug efflux system protein MdtG; Provisional; Region: PRK09874
498216006496	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
498216006497	putative substrate translocation pore; other site
498216006498	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
498216006499	putative substrate translocation pore; other site
498216006500	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
498216006501	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100
498216006502	NAD(P) binding site [chemical binding]; other site
498216006503	catalytic residues [active]
498216006504	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
498216006505	mRNA/rRNA interface [nucleotide binding]; other site
498216006506	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
498216006507	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
498216006508	23S rRNA interface [nucleotide binding]; other site
498216006509	L7/L12 interface [polypeptide binding]; other site
498216006510	putative thiostrepton binding site; other site
498216006511	L25 interface [polypeptide binding]; other site
498216006512	magnesium-transporting ATPase; Provisional; Region: PRK15122
498216006513	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
498216006514	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
498216006515	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
498216006516	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
498216006517	motif II; other site
498216006518	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
498216006519	amidase; Provisional; Region: PRK06529
498216006520	Amidase; Region: Amidase; cl11426
498216006521	Domain of unknown function (DU1801); Region: DUF1801; cl17490
498216006522	Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923
498216006523	ribonucleoside-triphosphate reductase, adenosylcobalamin-dependent; Region: RTPR; TIGR02505
498216006524	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
498216006525	Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014
498216006526	Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028
498216006527	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
498216006528	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
498216006529	putative homodimer interface [polypeptide binding]; other site
498216006530	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
498216006531	heterodimer interface [polypeptide binding]; other site
498216006532	homodimer interface [polypeptide binding]; other site
498216006533	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597
498216006534	Ribosomal protein L33; Region: Ribosomal_L33; cl00383
498216006535	1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; cl17224
498216006536	UbiA prenyltransferase family; Region: UbiA; pfam01040
498216006537	1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; cl17224
498216006538	UbiA prenyltransferase family; Region: UbiA; pfam01040
498216006539	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
498216006540	ApbE family; Region: ApbE; pfam02424
498216006541	This conserved region includes the FMN-binding site of the NqrC protein as well as the NosR and NirI regulatory proteins; Region: FMN_bind; smart00900
498216006542	This conserved region includes the FMN-binding site of the NqrC protein as well as the NosR and NirI regulatory proteins; Region: FMN_bind; smart00900
498216006543	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
498216006544	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
498216006545	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
498216006546	Listerrria innocua Lin0431  is similar to the N-Utilization Substance G (NusG) N terminal (NGN) insert (DII); Region: Lin0431_like; cd09911
498216006547	trimer interface [polypeptide binding]; other site
498216006548	Heptaprenyl diphosphate synthase component I; Region: Hpre_diP_synt_I; pfam07456
498216006549	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
498216006550	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
498216006551	substrate binding pocket [chemical binding]; other site
498216006552	chain length determination region; other site
498216006553	substrate-Mg2+ binding site; other site
498216006554	catalytic residues [active]
498216006555	aspartate-rich region 1; other site
498216006556	active site lid residues [active]
498216006557	aspartate-rich region 2; other site
498216006558	type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375
498216006559	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
498216006560	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
498216006561	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
498216006562	YacP-like NYN domain; Region: NYN_YacP; pfam05991
498216006563	rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186
498216006564	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
498216006565	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
498216006566	Ribonuclease III family protein [Replication, recombination, and    repair]; Region: COG1939
498216006567	active site
498216006568	metal binding site [ion binding]; metal-binding site
498216006569	dimerization interface [polypeptide binding]; other site
498216006570	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
498216006571	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
498216006572	active site
498216006573	HIGH motif; other site
498216006574	nucleotide binding site [chemical binding]; other site
498216006575	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
498216006576	KMSKS motif; other site
498216006577	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
498216006578	tRNA binding surface [nucleotide binding]; other site
498216006579	anticodon binding site; other site
498216006580	FAD binding domain; Region: FAD_binding_4; pfam01565
498216006581	glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387
498216006582	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
498216006583	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
498216006584	active site
498216006585	HIGH motif; other site
498216006586	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
498216006587	active site
498216006588	KMSKS motif; other site
498216006589	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
498216006590	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
498216006591	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
498216006592	tetramer (dimer of dimers) interface [polypeptide binding]; other site
498216006593	active site
498216006594	dimer interface [polypeptide binding]; other site
498216006595	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
498216006596	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
498216006597	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
498216006598	putative active site [active]
498216006599	Putative membrane peptidase family (DUF2324); Region: DUF2324; pfam10086
498216006600	Predicted membrane protein [General function prediction only]; Region: COG4194
498216006601	Predicted transcriptional regulators [Transcription]; Region: COG1725
498216006602	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
498216006603	DNA-binding site [nucleotide binding]; DNA binding site
498216006604	KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715
498216006605	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
498216006606	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
498216006607	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
498216006608	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
498216006609	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
498216006610	ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268
498216006611	Walker A/P-loop; other site
498216006612	ATP binding site [chemical binding]; other site
498216006613	Q-loop/lid; other site
498216006614	ABC transporter signature motif; other site
498216006615	Walker B; other site
498216006616	D-loop; other site
498216006617	H-loop/switch region; other site
498216006618	potential frameshift: common BLAST hit: gi|191639265|ref|YP_001988431.1| MutR
498216006619	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
498216006620	non-specific DNA binding site [nucleotide binding]; other site
498216006621	salt bridge; other site
498216006622	sequence-specific DNA binding site [nucleotide binding]; other site
498216006623	transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716
498216006624	PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877
498216006625	putative active site [active]
498216006626	DNA repair protein RadA; Provisional; Region: PRK11823
498216006627	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
498216006628	Walker A motif/ATP binding site; other site
498216006629	ATP binding site [chemical binding]; other site
498216006630	Walker B motif; other site
498216006631	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
498216006632	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
498216006633	trimer interface [polypeptide binding]; other site
498216006634	active site
498216006635	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
498216006636	Coenzyme A binding pocket [chemical binding]; other site
498216006637	Protein of unknown function (DUF805); Region: DUF805; pfam05656
498216006638	Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585
498216006639	trimer interface [polypeptide binding]; other site
498216006640	active site
498216006641	Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585
498216006642	trimer interface [polypeptide binding]; other site
498216006643	active site
498216006644	G bulge; other site
498216006645	ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277
498216006646	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
498216006647	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
498216006648	Walker A/P-loop; other site
498216006649	ATP binding site [chemical binding]; other site
498216006650	Q-loop/lid; other site
498216006651	ABC transporter signature motif; other site
498216006652	Walker B; other site
498216006653	D-loop; other site
498216006654	H-loop/switch region; other site
498216006655	K+ potassium transporter; Region: K_trans; pfam02705
498216006656	pyruvate phosphate dikinase; Provisional; Region: PRK09279
498216006657	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
498216006658	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
498216006659	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
498216006660	HTH domain; Region: HTH_11; pfam08279
498216006661	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
498216006662	FOG: CBS domain [General function prediction only]; Region: COG0517
498216006663	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
498216006664	catalytic core [active]
498216006665	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040
498216006666	Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754
498216006667	L-lactate oxidase; Region: L_lactate_ox; TIGR02708
498216006668	L-Lactate oxidase (LOX) FMN-binding domain. LOX is a member of the family of FMN-containing alpha-hydroxyacid oxidases and catalyzes the oxidation of l-lactate using molecular oxygen to generate pyruvate and H2O2.  This family occurs in both prokaryotes...; Region: LOX_like_FMN; cd04737
498216006669	teramer interface [polypeptide binding]; other site
498216006670	active site
498216006671	FMN binding site [chemical binding]; other site
498216006672	catalytic residues [active]
498216006673	CsbD-like; Region: CsbD; pfam05532
498216006674	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
498216006675	H+ Antiporter protein; Region: 2A0121; TIGR00900
498216006676	putative substrate translocation pore; other site
498216006677	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
498216006678	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
498216006679	putative catalytic cysteine [active]
498216006680	gamma-glutamyl kinase; Provisional; Region: PRK05429
498216006681	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
498216006682	nucleotide binding site [chemical binding]; other site
498216006683	homotetrameric interface [polypeptide binding]; other site
498216006684	putative phosphate binding site [ion binding]; other site
498216006685	putative allosteric binding site; other site
498216006686	Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827
498216006687	active site
498216006688	catalytic site [active]
498216006689	fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226
498216006690	Cna protein B-type domain; Region: Cna_B; pfam05738
498216006691	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
498216006692	Helix-turn-helix domain; Region: HTH_38; pfam13936
498216006693	Integrase core domain; Region: rve; pfam00665
498216006694	Cna protein B-type domain; Region: Cna_B; pfam05738
498216006695	Cna protein B-type domain; Region: Cna_B; pfam05738
498216006696	Uncharacterized conserved protein (DUF2075); Region: DUF2075; pfam09848
498216006697	Uncharacterized conserved protein [Function unknown]; Region: COG3410
498216006698	Protein of unknown function (DUF2974); Region: DUF2974; pfam11187
498216006699	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
498216006700	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
498216006701	non-specific DNA binding site [nucleotide binding]; other site
498216006702	salt bridge; other site
498216006703	sequence-specific DNA binding site [nucleotide binding]; other site
498216006704	Predicted transcriptional regulators [Transcription]; Region: COG1695
498216006705	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
498216006706	Enterocin A Immunity; Region: EntA_Immun; pfam08951
498216006707	Enterocin A Immunity; Region: EntA_Immun; pfam08951
498216006708	Enterocin A Immunity; Region: EntA_Immun; pfam08951
498216006709	Uncharacterized conserved protein [Function unknown]; Region: COG2966
498216006710	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
498216006711	Protein of unknown function (DUF3815); Region: DUF3815; cl01118
498216006712	bacteriocin secretion accessory protein; Region: bacteriocin_acc; TIGR01000
498216006713	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
498216006714	HlyD family secretion protein; Region: HlyD_3; pfam13437
498216006715	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418
498216006716	ABC-type bacteriocin transporter; Region: bacteriocin_ABC; TIGR01193
498216006717	putative active site [active]
498216006718	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
498216006719	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
498216006720	Walker A/P-loop; other site
498216006721	ATP binding site [chemical binding]; other site
498216006722	Q-loop/lid; other site
498216006723	ABC transporter signature motif; other site
498216006724	Walker B; other site
498216006725	D-loop; other site
498216006726	H-loop/switch region; other site
498216006727	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
498216006728	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
498216006729	active site
498216006730	phosphorylation site [posttranslational modification]
498216006731	intermolecular recognition site; other site
498216006732	dimerization interface [polypeptide binding]; other site
498216006733	LytTr DNA-binding domain; Region: LytTR; pfam04397
498216006734	CAAX protease self-immunity; Region: Abi; pfam02517
498216006735	Enterocin A Immunity; Region: EntA_Immun; pfam08951
498216006736	maltose O-acetyltransferase; Provisional; Region: PRK10092
498216006737	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
498216006738	active site
498216006739	substrate binding site [chemical binding]; other site
498216006740	trimer interface [polypeptide binding]; other site
498216006741	CoA binding site [chemical binding]; other site
498216006742	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
498216006743	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
498216006744	active site
498216006745	catalytic tetrad [active]
498216006746	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
498216006747	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
498216006748	NAD(P) binding site [chemical binding]; other site
498216006749	active site
498216006750	Old yellow enzyme (OYE)-related FMN binding domain, group 4.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735
498216006751	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
498216006752	putative active site [active]
498216006753	putative FMN binding site [chemical binding]; other site
498216006754	putative substrate binding site [chemical binding]; other site
498216006755	putative catalytic residue [active]
498216006756	fumarate hydratase; Reviewed; Region: fumC; PRK00485
498216006757	Class II fumarases; Region: Fumarase_classII; cd01362
498216006758	active site
498216006759	tetramer interface [polypeptide binding]; other site
498216006760	manganese transport protein MntH; Reviewed; Region: PRK00701
498216006761	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
498216006762	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
498216006763	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
498216006764	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
498216006765	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
498216006766	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
498216006767	motif II; other site
498216006768	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
498216006769	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
498216006770	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
498216006771	putative substrate translocation pore; other site
498216006772	multicopper oxidase; Provisional; Region: PRK10965
498216006773	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
498216006774	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
498216006775	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
498216006776	Cation efflux family; Region: Cation_efflux; cl00316
498216006777	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
498216006778	dimerization interface [polypeptide binding]; other site
498216006779	putative DNA binding site [nucleotide binding]; other site
498216006780	putative Zn2+ binding site [ion binding]; other site
498216006781	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
498216006782	Metal binding protein PsaA.  These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137
498216006783	metal binding site [ion binding]; metal-binding site
498216006784	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
498216006785	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
498216006786	ABC-ATPase subunit  interface; other site
498216006787	dimer interface [polypeptide binding]; other site
498216006788	putative PBP binding regions; other site
498216006789	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
498216006790	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
498216006791	Escherichia coli lactaldehyde dehydrogenase AldA-like; Region: ALDH_LactADH-AldA; cd07088
498216006792	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
498216006793	NAD binding site [chemical binding]; other site
498216006794	catalytic residues [active]
498216006795	substrate binding site [chemical binding]; other site
498216006796	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
498216006797	Metal binding protein TroA_b.  These proteins are predicted to function as initial receptors in ABC transport of metal ions.  They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: TroA_b; cd01020
498216006798	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
498216006799	metal binding site [ion binding]; metal-binding site
498216006800	atypical (a) SDRs, subgroup 6; Region: SDR_a6; cd05267
498216006801	NADH(P)-binding; Region: NAD_binding_10; pfam13460
498216006802	putative NAD(P) binding site [chemical binding]; other site
498216006803	Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535
498216006804	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672
498216006805	nudix motif; other site
498216006806	Collagen binding domain; Region: Collagen_bind; pfam05737
498216006807	Cna protein B-type domain; Region: Cna_B; pfam05738
498216006808	Metal binding protein TroA_b.  These proteins are predicted to function as initial receptors in ABC transport of metal ions.  They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: TroA_b; cd01020
498216006809	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
498216006810	metal binding site [ion binding]; metal-binding site
498216006811	KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715
498216006812	SEC10/PgrA surface exclusion domain; Region: Surf_Exclu_PgrA; TIGR04320
498216006813	Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239
498216006814	enolase; Provisional; Region: eno; PRK00077
498216006815	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
498216006816	dimer interface [polypeptide binding]; other site
498216006817	metal binding site [ion binding]; metal-binding site
498216006818	substrate binding pocket [chemical binding]; other site
498216006819	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
498216006820	plasma-membrane proton-efflux P-type ATPase; Region: ATPase-IIIA_H; TIGR01647
498216006821	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
498216006822	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
498216006823	motif II; other site
498216006824	phosphate/phosphite/phosphonate ABC transporters, periplasmic binding protein; Region: 3A0109s03R; TIGR01098
498216006825	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
498216006826	membrane-bound complex binding site; other site
498216006827	hinge residues; other site
498216006828	ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638
498216006829	ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256
498216006830	Walker A/P-loop; other site
498216006831	ATP binding site [chemical binding]; other site
498216006832	Q-loop/lid; other site
498216006833	ABC transporter signature motif; other site
498216006834	Walker B; other site
498216006835	D-loop; other site
498216006836	H-loop/switch region; other site
498216006837	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
498216006838	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
498216006839	dimer interface [polypeptide binding]; other site
498216006840	conserved gate region; other site
498216006841	putative PBP binding loops; other site
498216006842	ABC-ATPase subunit interface; other site
498216006843	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
498216006844	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
498216006845	dimer interface [polypeptide binding]; other site
498216006846	conserved gate region; other site
498216006847	putative PBP binding loops; other site
498216006848	ABC-ATPase subunit interface; other site
498216006849	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
498216006850	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
498216006851	substrate binding pocket [chemical binding]; other site
498216006852	membrane-bound complex binding site; other site
498216006853	hinge residues; other site
498216006854	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
498216006855	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
498216006856	Subfamily of fatty acid CoA ligase (FACL) similar to Fum10p of Gibberella moniliformis; Region: FACL_fum10p_like; cd05926
498216006857	acyl-activating enzyme (AAE) consensus motif; other site
498216006858	acyl-activating enzyme (AAE) consensus motif; other site
498216006859	putative AMP binding site [chemical binding]; other site
498216006860	putative active site [active]
498216006861	putative CoA binding site [chemical binding]; other site
498216006862	Acyltransferase family; Region: Acyl_transf_3; pfam01757
498216006863	aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247
498216006864	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
498216006865	Walker A/P-loop; other site
498216006866	ATP binding site [chemical binding]; other site
498216006867	Q-loop/lid; other site
498216006868	ABC transporter signature motif; other site
498216006869	Walker B; other site
498216006870	D-loop; other site
498216006871	H-loop/switch region; other site
498216006872	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
498216006873	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
498216006874	putative PBP binding loops; other site
498216006875	dimer interface [polypeptide binding]; other site
498216006876	ABC-ATPase subunit interface; other site
498216006877	ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496
498216006878	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587
498216006879	ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496
498216006880	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586
498216006881	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
498216006882	Walker A/P-loop; other site
498216006883	ATP binding site [chemical binding]; other site
498216006884	Q-loop/lid; other site
498216006885	ABC transporter signature motif; other site
498216006886	Walker B; other site
498216006887	D-loop; other site
498216006888	H-loop/switch region; other site
498216006889	Protein of unknown function (DUF2785); Region: DUF2785; pfam10978
498216006890	Protein of unknown function (DUF2785); Region: DUF2785; pfam10978
498216006891	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
498216006892	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
498216006893	23S rRNA interface [nucleotide binding]; other site
498216006894	L3 interface [polypeptide binding]; other site
498216006895	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
498216006896	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
498216006897	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
498216006898	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
498216006899	Walker A/P-loop; other site
498216006900	ATP binding site [chemical binding]; other site
498216006901	Q-loop/lid; other site
498216006902	ABC transporter signature motif; other site
498216006903	Walker B; other site
498216006904	D-loop; other site
498216006905	H-loop/switch region; other site
498216006906	Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106
498216006907	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
498216006908	DNA binding residues [nucleotide binding]
498216006909	dimer interface [polypeptide binding]; other site
498216006910	TipAS antibiotic-recognition domain; Region: TipAS; pfam07739
498216006911	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
498216006912	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
498216006913	dimerization interface 3.5A [polypeptide binding]; other site
498216006914	active site
498216006915	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
498216006916	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634
498216006917	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
498216006918	Walker A/P-loop; other site
498216006919	ATP binding site [chemical binding]; other site
498216006920	Q-loop/lid; other site
498216006921	ABC transporter signature motif; other site
498216006922	Walker B; other site
498216006923	D-loop; other site
498216006924	H-loop/switch region; other site
498216006925	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635
498216006926	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
498216006927	Walker A/P-loop; other site
498216006928	ATP binding site [chemical binding]; other site
498216006929	Q-loop/lid; other site
498216006930	ABC transporter signature motif; other site
498216006931	Walker B; other site
498216006932	D-loop; other site
498216006933	H-loop/switch region; other site
498216006934	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
498216006935	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
498216006936	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
498216006937	alphaNTD homodimer interface [polypeptide binding]; other site
498216006938	alphaNTD - beta interaction site [polypeptide binding]; other site
498216006939	alphaNTD - beta' interaction site [polypeptide binding]; other site
498216006940	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
498216006941	30S ribosomal protein S11; Validated; Region: PRK05309
498216006942	Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099
498216006943	30S ribosomal protein S13; Region: bact_S13; TIGR03631
498216006944	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
498216006945	rRNA binding site [nucleotide binding]; other site
498216006946	predicted 30S ribosome binding site; other site
498216006947	adenylate kinase; Reviewed; Region: adk; PRK00279
498216006948	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
498216006949	AMP-binding site [chemical binding]; other site
498216006950	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
498216006951	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
498216006952	SecY translocase; Region: SecY; pfam00344
498216006953	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
498216006954	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
498216006955	23S rRNA binding site [nucleotide binding]; other site
498216006956	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
498216006957	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
498216006958	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
498216006959	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
498216006960	5S rRNA interface [nucleotide binding]; other site
498216006961	L27 interface [polypeptide binding]; other site
498216006962	23S rRNA interface [nucleotide binding]; other site
498216006963	L5 interface [polypeptide binding]; other site
498216006964	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
498216006965	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
498216006966	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
498216006967	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
498216006968	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061
498216006969	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
498216006970	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
498216006971	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
498216006972	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
498216006973	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
498216006974	RNA binding site [nucleotide binding]; other site
498216006975	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
498216006976	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
498216006977	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
498216006978	23S rRNA interface [nucleotide binding]; other site
498216006979	putative translocon interaction site; other site
498216006980	signal recognition particle (SRP54) interaction site; other site
498216006981	L23 interface [polypeptide binding]; other site
498216006982	trigger factor interaction site; other site
498216006983	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
498216006984	23S rRNA interface [nucleotide binding]; other site
498216006985	5S rRNA interface [nucleotide binding]; other site
498216006986	putative antibiotic binding site [chemical binding]; other site
498216006987	L25 interface [polypeptide binding]; other site
498216006988	L27 interface [polypeptide binding]; other site
498216006989	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
498216006990	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
498216006991	G-X-X-G motif; other site
498216006992	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
498216006993	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
498216006994	putative translocon binding site; other site
498216006995	protein-rRNA interface [nucleotide binding]; other site
498216006996	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
498216006997	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
498216006998	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
498216006999	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
498216007000	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
498216007001	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
498216007002	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
498216007003	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
498216007004	phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833
498216007005	peroxiredoxin; Region: AhpC; TIGR03137
498216007006	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
498216007007	dimer interface [polypeptide binding]; other site
498216007008	decamer (pentamer of dimers) interface [polypeptide binding]; other site
498216007009	catalytic triad [active]
498216007010	peroxidatic and resolving cysteines [active]
498216007011	Predicted transcriptional regulator [Transcription]; Region: COG2378
498216007012	WYL domain; Region: WYL; pfam13280
498216007013	elongation factor G; Reviewed; Region: PRK12739
498216007014	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
498216007015	G1 box; other site
498216007016	putative GEF interaction site [polypeptide binding]; other site
498216007017	GTP/Mg2+ binding site [chemical binding]; other site
498216007018	Switch I region; other site
498216007019	G2 box; other site
498216007020	G3 box; other site
498216007021	Switch II region; other site
498216007022	G4 box; other site
498216007023	G5 box; other site
498216007024	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
498216007025	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
498216007026	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
498216007027	30S ribosomal protein S7; Validated; Region: PRK05302
498216007028	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
498216007029	S17 interaction site [polypeptide binding]; other site
498216007030	S8 interaction site; other site
498216007031	16S rRNA interaction site [nucleotide binding]; other site
498216007032	streptomycin interaction site [chemical binding]; other site
498216007033	23S rRNA interaction site [nucleotide binding]; other site
498216007034	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
498216007035	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
498216007036	Cna protein B-type domain; Region: Cna_B; pfam05738
498216007037	Cna protein B-type domain; Region: Cna_B; pfam05738
498216007038	Cna protein B-type domain; Region: Cna_B; pfam05738
498216007039	Cna protein B-type domain; Region: Cna_B; pfam05738
498216007040	Cna protein B-type domain; Region: Cna_B; pfam05738
498216007041	Cna protein B-type domain; Region: Cna_B; pfam05738
498216007042	Cna protein B-type domain; Region: Cna_B; pfam05738
498216007043	Cna protein B-type domain; Region: Cna_B; pfam05738
498216007044	Cna protein B-type domain; Region: Cna_B; pfam05738
498216007045	Cna protein B-type domain; Region: Cna_B; pfam05738
498216007046	DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566
498216007047	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
498216007048	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
498216007049	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
498216007050	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
498216007051	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
498216007052	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
498216007053	DNA binding site [nucleotide binding]
498216007054	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
498216007055	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
498216007056	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
498216007057	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
498216007058	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
498216007059	RPB1 interaction site [polypeptide binding]; other site
498216007060	RPB10 interaction site [polypeptide binding]; other site
498216007061	RPB11 interaction site [polypeptide binding]; other site
498216007062	RPB3 interaction site [polypeptide binding]; other site
498216007063	RPB12 interaction site [polypeptide binding]; other site
498216007064	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
498216007065	Clp amino terminal domain; Region: Clp_N; pfam02861
498216007066	Clp amino terminal domain; Region: Clp_N; pfam02861
498216007067	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
498216007068	Walker A motif; other site
498216007069	ATP binding site [chemical binding]; other site
498216007070	Walker B motif; other site
498216007071	arginine finger; other site
498216007072	UvrB/uvrC motif; Region: UVR; pfam02151
498216007073	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
498216007074	Walker A motif; other site
498216007075	ATP binding site [chemical binding]; other site
498216007076	Walker B motif; other site
498216007077	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
498216007078	Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848
498216007079	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
498216007080	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
498216007081	FMN binding site [chemical binding]; other site
498216007082	active site
498216007083	catalytic residues [active]
498216007084	substrate binding site [chemical binding]; other site
498216007085	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
498216007086	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
498216007087	dimerization interface [polypeptide binding]; other site
498216007088	domain crossover interface; other site
498216007089	redox-dependent activation switch; other site
498216007090	FtsH Extracellular; Region: FtsH_ext; pfam06480
498216007091	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
498216007092	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
498216007093	Walker A motif; other site
498216007094	ATP binding site [chemical binding]; other site
498216007095	Walker B motif; other site
498216007096	arginine finger; other site
498216007097	Peptidase family M41; Region: Peptidase_M41; pfam01434
498216007098	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
498216007099	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
498216007100	active site
498216007101	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
498216007102	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
498216007103	Ligand Binding Site [chemical binding]; other site
498216007104	TilS substrate C-terminal domain; Region: TilS_C; smart00977
498216007105	hypothetical protein; Provisional; Region: PRK08582
498216007106	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
498216007107	RNA binding site [nucleotide binding]; other site
498216007108	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
498216007109	Septum formation initiator; Region: DivIC; pfam04977
498216007110	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
498216007111	RNA binding surface [nucleotide binding]; other site
498216007112	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
498216007113	Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124
498216007114	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
498216007115	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
498216007116	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
498216007117	ATP binding site [chemical binding]; other site
498216007118	putative Mg++ binding site [ion binding]; other site
498216007119	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
498216007120	nucleotide binding region [chemical binding]; other site
498216007121	ATP-binding site [chemical binding]; other site
498216007122	TRCF domain; Region: TRCF; pfam03461
498216007123	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
498216007124	putative active site [active]
498216007125	catalytic residue [active]
498216007126	L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066
498216007127	L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291
498216007128	tetramer (dimer of dimers) interface [polypeptide binding]; other site
498216007129	NAD binding site [chemical binding]; other site
498216007130	dimer interface [polypeptide binding]; other site
498216007131	substrate binding site [chemical binding]; other site
498216007132	Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229
498216007133	Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229
498216007134	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
498216007135	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
498216007136	FOG: CBS domain [General function prediction only]; Region: COG0517
498216007137	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
498216007138	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
498216007139	glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810
498216007140	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
498216007141	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
498216007142	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
498216007143	active site
498216007144	dimer interface [polypeptide binding]; other site
498216007145	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
498216007146	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
498216007147	active site
498216007148	FMN binding site [chemical binding]; other site
498216007149	substrate binding site [chemical binding]; other site
498216007150	3Fe-4S cluster binding site [ion binding]; other site
498216007151	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
498216007152	domain interface; other site
498216007153	QueT transporter; Region: QueT; pfam06177
498216007154	PemK-like protein; Region: PemK; pfam02452
498216007155	hypothetical protein; Region: PHA01623
498216007156	alanine racemase; Reviewed; Region: alr; PRK00053
498216007157	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
498216007158	active site
498216007159	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
498216007160	dimer interface [polypeptide binding]; other site
498216007161	substrate binding site [chemical binding]; other site
498216007162	catalytic residues [active]
498216007163	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
498216007164	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
498216007165	DEAD-like helicases superfamily; Region: DEXDc; smart00487
498216007166	ATP binding site [chemical binding]; other site
498216007167	Mg++ binding site [ion binding]; other site
498216007168	motif III; other site
498216007169	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
498216007170	nucleotide binding region [chemical binding]; other site
498216007171	ATP-binding site [chemical binding]; other site
498216007172	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
498216007173	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
498216007174	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
498216007175	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
498216007176	50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678
498216007177	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
498216007178	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
498216007179	hinge; other site
498216007180	active site
498216007181	CTP synthetase; Validated; Region: pyrG; PRK05380
498216007182	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
498216007183	Catalytic site [active]
498216007184	active site
498216007185	UTP binding site [chemical binding]; other site
498216007186	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
498216007187	active site
498216007188	putative oxyanion hole; other site
498216007189	catalytic triad [active]
498216007190	Protein of unknown function (DUF1211); Region: DUF1211; cl01421
498216007191	DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066
498216007192	Domain of unknown function (DUF1934); Region: DUF1934; pfam09148
498216007193	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
498216007194	HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078
498216007195	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
498216007196	Zn2+ binding site [ion binding]; other site
498216007197	Mg2+ binding site [ion binding]; other site
498216007198	Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684
498216007199	nudix motif; other site
498216007200	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
498216007201	putative active site [active]
498216007202	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
498216007203	large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952
498216007204	imidazolonepropionase; Validated; Region: PRK09356
498216007205	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
498216007206	Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299
498216007207	active site
498216007208	ASC-1 homology domain, subfamily similar to Pyrococcus furiosus Pf0470. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_PF0470_like; cd06555
498216007209	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
498216007210	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
498216007211	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
498216007212	active site
498216007213	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354
498216007214	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
498216007215	Substrate binding site; other site
498216007216	Mg++ binding site; other site
498216007217	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
498216007218	active site
498216007219	substrate binding site [chemical binding]; other site
498216007220	CoA binding site [chemical binding]; other site
498216007221	VanZ like family; Region: VanZ; pfam04892
498216007222	RDD family; Region: RDD; pfam06271
498216007223	pur operon repressor; Provisional; Region: PRK09213
498216007224	Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182
498216007225	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
498216007226	active site
498216007227	putative ABC transporter ATP-binding protein YbbL; Provisional; Region: PRK10247
498216007228	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
498216007229	Walker A/P-loop; other site
498216007230	ATP binding site [chemical binding]; other site
498216007231	Q-loop/lid; other site
498216007232	ABC transporter signature motif; other site
498216007233	Walker B; other site
498216007234	D-loop; other site
498216007235	H-loop/switch region; other site
498216007236	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390
498216007237	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
498216007238	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
498216007239	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128
498216007240	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
498216007241	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
498216007242	Protein of unknown function (DUF1021); Region: DUF1021; pfam06257
498216007243	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
498216007244	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
498216007245	S-adenosylmethionine binding site [chemical binding]; other site
498216007246	ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334
498216007247	TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea.  RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027
498216007248	putative active site [active]
498216007249	putative metal binding site [ion binding]; other site
498216007250	Domain of unknown function (DUF4093); Region: DUF4093; pfam13331
498216007251	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
498216007252	active site
498216007253	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163
498216007254	active site
498216007255	phosphorylation site [posttranslational modification]
498216007256	tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK12399
498216007257	Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024
498216007258	active site
498216007259	catalytic residues [active]
498216007260	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
498216007261	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
498216007262	active site
498216007263	phosphorylation site [posttranslational modification]
498216007264	intermolecular recognition site; other site
498216007265	dimerization interface [polypeptide binding]; other site
498216007266	LytTr DNA-binding domain; Region: LytTR; smart00850
498216007267	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
498216007268	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
498216007269	ATP binding site [chemical binding]; other site
498216007270	Mg2+ binding site [ion binding]; other site
498216007271	G-X-G motif; other site
498216007272	ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265
498216007273	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
498216007274	Walker A/P-loop; other site
498216007275	ATP binding site [chemical binding]; other site
498216007276	Q-loop/lid; other site
498216007277	ABC transporter signature motif; other site
498216007278	Walker B; other site
498216007279	D-loop; other site
498216007280	H-loop/switch region; other site
498216007281	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
498216007282	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
498216007283	Walker A/P-loop; other site
498216007284	ATP binding site [chemical binding]; other site
498216007285	Q-loop/lid; other site
498216007286	ABC transporter signature motif; other site
498216007287	Walker B; other site
498216007288	D-loop; other site
498216007289	H-loop/switch region; other site
498216007290	methionyl-tRNA synthetase; Reviewed; Region: PRK12267
498216007291	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
498216007292	active site
498216007293	HIGH motif; other site
498216007294	KMSKS motif; other site
498216007295	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
498216007296	tRNA binding surface [nucleotide binding]; other site
498216007297	anticodon binding site; other site
498216007298	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
498216007299	dimer interface [polypeptide binding]; other site
498216007300	putative tRNA-binding site [nucleotide binding]; other site
498216007301	proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250
498216007302	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
498216007303	Protein of unknown function DUF72; Region: DUF72; pfam01904
498216007304	MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427
498216007305	putative active site [active]
498216007306	nucleotide binding site [chemical binding]; other site
498216007307	nudix motif; other site
498216007308	putative metal binding site [ion binding]; other site
498216007309	NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195
498216007310	L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771
498216007311	LDH/MDH dimer interface [polypeptide binding]; other site
498216007312	NAD(P) binding site [chemical binding]; other site
498216007313	substrate binding site [chemical binding]; other site
498216007314	Protein of unknown function (DUF1211); Region: DUF1211; cl01421
498216007315	NAD-dependent deacetylase; Provisional; Region: PRK00481
498216007316	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
498216007317	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
498216007318	substrate binding site [chemical binding]; other site
498216007319	Predicted secreted protein [Function unknown]; Region: COG4086
498216007320	Protein of unknown function (DUF1002); Region: DUF1002; pfam06207
498216007321	exopolyphosphatase; Region: exo_poly_only; TIGR03706
498216007322	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
498216007323	polyphosphate kinase; Provisional; Region: PRK05443
498216007324	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
498216007325	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
498216007326	Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165
498216007327	putative domain interface [polypeptide binding]; other site
498216007328	putative active site [active]
498216007329	catalytic site [active]
498216007330	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
498216007331	putative domain interface [polypeptide binding]; other site
498216007332	putative active site [active]
498216007333	catalytic site [active]
498216007334	exopolyphosphatase; Region: exo_poly_only; TIGR03706
498216007335	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
498216007336	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
498216007337	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
498216007338	active site
498216007339	catalytic tetrad [active]
498216007340	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
498216007341	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
498216007342	S-adenosylmethionine binding site [chemical binding]; other site
498216007343	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
498216007344	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
498216007345	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
498216007346	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138
498216007347	Repair protein; Region: Repair_PSII; pfam04536
498216007348	Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704
498216007349	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
498216007350	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
498216007351	active site
498216007352	HIGH motif; other site
498216007353	dimer interface [polypeptide binding]; other site
498216007354	KMSKS motif; other site
498216007355	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
498216007356	ABC transporter signature motif; other site
498216007357	Walker B; other site
498216007358	D-loop; other site
498216007359	H-loop/switch region; other site
498216007360	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
498216007361	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
498216007362	FtsX-like permease family; Region: FtsX; pfam02687
498216007363	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
498216007364	Walker A/P-loop; other site
498216007365	ATP binding site [chemical binding]; other site
498216007366	Q-loop/lid; other site
498216007367	Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249
498216007368	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
498216007369	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
498216007370	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
498216007371	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
498216007372	Walker A/P-loop; other site
498216007373	ATP binding site [chemical binding]; other site
498216007374	Q-loop/lid; other site
498216007375	ABC transporter signature motif; other site
498216007376	Walker B; other site
498216007377	D-loop; other site
498216007378	H-loop/switch region; other site
498216007379	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
498216007380	conserved gate region; other site
498216007381	ABC-ATPase subunit interface; other site
498216007382	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
498216007383	Transcriptional regulator [Transcription]; Region: LysR; COG0583
498216007384	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
498216007385	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
498216007386	dimerization interface [polypeptide binding]; other site
498216007387	Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275
498216007388	C4-dicarboxylate transporters of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_C4-dicarb_trans; cd09325
498216007389	gating phenylalanine in ion channel; other site
498216007390	CAAX protease self-immunity; Region: Abi; pfam02517
498216007391	Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418
498216007392	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215
498216007393	Zn2+ binding site [ion binding]; other site
498216007394	Mg2+ binding site [ion binding]; other site
498216007395	Transcriptional regulators [Transcription]; Region: MarR; COG1846
498216007396	MarR family; Region: MarR_2; pfam12802
498216007397	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
498216007398	Walker A/P-loop; other site
498216007399	ATP binding site [chemical binding]; other site
498216007400	Q-loop/lid; other site
498216007401	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
498216007402	Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178
498216007403	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
498216007404	ABC transporter signature motif; other site
498216007405	Walker B; other site
498216007406	D-loop; other site
498216007407	H-loop/switch region; other site
498216007408	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
498216007409	Walker A/P-loop; other site
498216007410	ATP binding site [chemical binding]; other site
498216007411	Q-loop/lid; other site
498216007412	ABC transporter signature motif; other site
498216007413	Walker B; other site
498216007414	D-loop; other site
498216007415	H-loop/switch region; other site
498216007416	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
498216007417	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
498216007418	active site
498216007419	catalytic tetrad [active]
498216007420	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
498216007421	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
498216007422	Protein of unknown function (DUF1275); Region: DUF1275; pfam06912
498216007423	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
498216007424	catalytic core [active]
498216007425	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399
498216007426	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
498216007427	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
498216007428	active site
498216007429	motif I; other site
498216007430	motif II; other site
498216007431	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
498216007432	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
498216007433	RNA/DNA hybrid binding site [nucleotide binding]; other site
498216007434	active site
498216007435	Transcriptional regulator [Transcription]; Region: LysR; COG0583
498216007436	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
498216007437	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
498216007438	dimerization interface [polypeptide binding]; other site
498216007439	Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436
498216007440	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
498216007441	pyridoxal 5'-phosphate binding site [chemical binding]; other site
498216007442	homodimer interface [polypeptide binding]; other site
498216007443	catalytic residue [active]
498216007444	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
498216007445	RecA/RadA recombinase [DNA replication, recombination, and repair]; Region: RecA; COG0468
498216007446	hexamer interface [polypeptide binding]; other site
498216007447	Walker A motif; other site
498216007448	ATP binding site [chemical binding]; other site
498216007449	Walker B motif; other site
498216007450	Protein of unknown function (DUF554); Region: DUF554; pfam04474
498216007451	putative PTS system  transporter subunits IIBC; Provisional; Region: PRK11404
498216007452	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
498216007453	active site
498216007454	P-loop; other site
498216007455	phosphorylation site [posttranslational modification]
498216007456	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
498216007457	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
498216007458	active site
498216007459	phosphorylation site [posttranslational modification]
498216007460	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
498216007461	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
498216007462	putative substrate binding site [chemical binding]; other site
498216007463	putative ATP binding site [chemical binding]; other site
498216007464	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
498216007465	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
498216007466	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
498216007467	putative active site [active]
498216007468	glycerol kinase; Provisional; Region: glpK; PRK00047
498216007469	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
498216007470	N- and C-terminal domain interface [polypeptide binding]; other site
498216007471	active site
498216007472	MgATP binding site [chemical binding]; other site
498216007473	catalytic site [active]
498216007474	metal binding site [ion binding]; metal-binding site
498216007475	glycerol binding site [chemical binding]; other site
498216007476	homotetramer interface [polypeptide binding]; other site
498216007477	homodimer interface [polypeptide binding]; other site
498216007478	FBP binding site [chemical binding]; other site
498216007479	protein IIAGlc interface [polypeptide binding]; other site
498216007480	galactonate dehydratase; Provisional; Region: PRK14017
498216007481	D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325
498216007482	putative active site pocket [active]
498216007483	putative metal binding site [ion binding]; other site
498216007484	Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775
498216007485	PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451
498216007486	PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS).  In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566
498216007487	active site
498216007488	P-loop; other site
498216007489	phosphorylation site [posttranslational modification]
498216007490	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
498216007491	active site
498216007492	phosphorylation site [posttranslational modification]
498216007493	2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800
498216007494	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
498216007495	active site
498216007496	intersubunit interface [polypeptide binding]; other site
498216007497	catalytic residue [active]
498216007498	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
498216007499	PRD domain; Region: PRD; pfam00874
498216007500	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
498216007501	active site
498216007502	P-loop; other site
498216007503	phosphorylation site [posttranslational modification]
498216007504	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
498216007505	active site
498216007506	phosphorylation site [posttranslational modification]
498216007507	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
498216007508	active site
498216007509	methionine cluster; other site
498216007510	phosphorylation site [posttranslational modification]
498216007511	metal binding site [ion binding]; metal-binding site
498216007512	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
498216007513	active site
498216007514	P-loop; other site
498216007515	phosphorylation site [posttranslational modification]
498216007516	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
498216007517	beta-galactosidase; Region: BGL; TIGR03356
498216007518	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
498216007519	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
498216007520	nucleotide binding site [chemical binding]; other site
498216007521	Uncharacterized conserved protein [Function unknown]; Region: COG3538
498216007522	Protein of unknown function (DUF1237); Region: DUF1237; pfam06824
498216007523	alpha-mannosidase; Provisional; Region: PRK09819
498216007524	N-terminal catalytic domain of Escherichia coli alpha-mannosidase MngB and its bacterial homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_EcMngB_like; cd10815
498216007525	active site
498216007526	metal binding site [ion binding]; metal-binding site
498216007527	catalytic site [active]
498216007528	Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536
498216007529	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
498216007530	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
498216007531	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
498216007532	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
498216007533	DNA-binding site [nucleotide binding]; DNA binding site
498216007534	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
498216007535	hypothetical protein; Provisional; Region: PRK06357
498216007536	intersubunit interface [polypeptide binding]; other site
498216007537	active site
498216007538	Zn2+ binding site [ion binding]; other site
498216007539	Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775
498216007540	PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451
498216007541	PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS).  In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566
498216007542	active site
498216007543	P-loop; other site
498216007544	phosphorylation site [posttranslational modification]
498216007545	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
498216007546	active site
498216007547	phosphorylation site [posttranslational modification]
498216007548	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
498216007549	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
498216007550	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
498216007551	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
498216007552	S-adenosylmethionine binding site [chemical binding]; other site
498216007553	Methyltransferase domain; Region: Methyltransf_31; pfam13847
498216007554	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
498216007555	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
498216007556	Ca binding site [ion binding]; other site
498216007557	active site
498216007558	catalytic site [active]
498216007559	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
498216007560	Right handed beta helix region; Region: Beta_helix; pfam13229
498216007561	Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940
498216007562	Preprotein translocase subunit; Region: YajC; pfam02699
498216007563	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025
498216007564	active pocket/dimerization site; other site
498216007565	active site
498216007566	phosphorylation site [posttranslational modification]
498216007567	PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613
498216007568	PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609
498216007569	PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830
498216007570	active site
498216007571	phosphorylation site [posttranslational modification]
498216007572	Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470
498216007573	Transcriptional regulator [Transcription]; Region: IclR; COG1414
498216007574	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
498216007575	Bacterial transcriptional regulator; Region: IclR; pfam01614
498216007576	5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924
498216007577	2-deoxy-D-gluconate 3-dehydrogenase; Provisional; Region: PRK06935
498216007578	gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347
498216007579	NADP binding site [chemical binding]; other site
498216007580	homodimer interface [polypeptide binding]; other site
498216007581	active site
498216007582	DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713
498216007583	A new structural DNA glycosylase containing HEAT-like repeats; Region: AlkD_like_1; cd07064
498216007584	active site
498216007585	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
498216007586	tetramer (dimer of dimers) interface [polypeptide binding]; other site
498216007587	active site
498216007588	dimer interface [polypeptide binding]; other site
498216007589	conserved hypothetical integral membrane protein; Region: TIGR03766
498216007590	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
498216007591	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
498216007592	Ligand binding site; other site
498216007593	Putative Catalytic site; other site
498216007594	DXD motif; other site
498216007595	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
498216007596	active site
498216007597	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
498216007598	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
498216007599	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
498216007600	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
498216007601	HAMP domain; Region: HAMP; pfam00672
498216007602	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
498216007603	dimer interface [polypeptide binding]; other site
498216007604	phosphorylation site [posttranslational modification]
498216007605	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
498216007606	ATP binding site [chemical binding]; other site
498216007607	Mg2+ binding site [ion binding]; other site
498216007608	G-X-G motif; other site
498216007609	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
498216007610	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
498216007611	active site
498216007612	phosphorylation site [posttranslational modification]
498216007613	intermolecular recognition site; other site
498216007614	dimerization interface [polypeptide binding]; other site
498216007615	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
498216007616	DNA binding site [nucleotide binding]
498216007617	Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486
498216007618	Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298
498216007619	NAD binding site [chemical binding]; other site
498216007620	sugar binding site [chemical binding]; other site
498216007621	divalent metal binding site [ion binding]; other site
498216007622	putative tetramer (dimer of dimers) interface [polypeptide binding]; other site
498216007623	dimer interface [polypeptide binding]; other site
498216007624	bifunctional PTS system maltose and glucose-specific transporter subunits IICB; Provisional; Region: PRK10110
498216007625	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
498216007626	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
498216007627	active site turn [active]
498216007628	phosphorylation site [posttranslational modification]
498216007629	Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cd01083
498216007630	substrate binding site [chemical binding]; other site
498216007631	catalytic residues [active]
498216007632	ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517
498216007633	Mga helix-turn-helix domain; Region: Mga; pfam05043
498216007634	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
498216007635	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
498216007636	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
498216007637	putative active site [active]
498216007638	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
498216007639	HPr interaction site; other site
498216007640	glycerol kinase (GK) interaction site [polypeptide binding]; other site
498216007641	active site
498216007642	phosphorylation site [posttranslational modification]
498216007643	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
498216007644	Homeodomain-like domain; Region: HTH_23; pfam13384
498216007645	Transposase; Region: DDE_Tnp_ISL3; pfam01610
498216007646	Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894
498216007647	triosephosphate isomerase; Provisional; Region: PRK04302
498216007648	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
498216007649	intersubunit interface [polypeptide binding]; other site
498216007650	active site
498216007651	zinc binding site [ion binding]; other site
498216007652	Na+ binding site [ion binding]; other site
498216007653	PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS).  In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566
498216007654	active site
498216007655	P-loop; other site
498216007656	phosphorylation site [posttranslational modification]
498216007657	Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775
498216007658	PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451
498216007659	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
498216007660	active site
498216007661	phosphorylation site [posttranslational modification]
498216007662	Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2; Region: PTS_EIIA_2; pfam00359
498216007663	active site
498216007664	phosphorylation site [posttranslational modification]
498216007665	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
498216007666	PRD domain; Region: PRD; pfam00874
498216007667	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
498216007668	active site
498216007669	P-loop; other site
498216007670	phosphorylation site [posttranslational modification]
498216007671	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
498216007672	TPR motif; other site
498216007673	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
498216007674	Uncharacterized conserved protein [Function unknown]; Region: COG1434
498216007675	putative active site [active]
498216007676	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
498216007677	4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557
498216007678	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395
498216007679	2-keto-3-deoxygluconate permease; Provisional; Region: PRK12460
498216007680	Propionate catabolism activator; Region: PrpR_N; pfam06506
498216007681	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
498216007682	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
498216007683	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
498216007684	putative active site [active]
498216007685	PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563
498216007686	active site
498216007687	P-loop; other site
498216007688	phosphorylation site [posttranslational modification]
498216007689	PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: PRK12997
498216007690	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
498216007691	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
498216007692	dimer interface [polypeptide binding]; other site
498216007693	active site
498216007694	catalytic residue [active]
498216007695	2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800
498216007696	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
498216007697	active site
498216007698	intersubunit interface [polypeptide binding]; other site
498216007699	catalytic residue [active]
498216007700	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
498216007701	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
498216007702	putative DNA binding site [nucleotide binding]; other site
498216007703	putative Zn2+ binding site [ion binding]; other site
498216007704	PRD domain; Region: PRD; pfam00874
498216007705	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
498216007706	active site
498216007707	P-loop; other site
498216007708	phosphorylation site [posttranslational modification]
498216007709	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
498216007710	active site
498216007711	phosphorylation site [posttranslational modification]
498216007712	Protein of unknown function (DUF1341); Region: DUF1341; pfam07071
498216007713	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
498216007714	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
498216007715	dihydroorotase; Provisional; Region: PRK09237
498216007716	active site
498216007717	Domain of unknown function (DUF4310); Region: DUF4310; pfam14187
498216007718	Domain of unknown function (DUF4311); Region: DUF4311; cl11919
498216007719	Domain of unknown function (DUF4312); Region: DUF4312; cl11917
498216007720	Glycine-rich SFCGS; Region: Gly_rich_SFCGS; pfam14272
498216007721	PRD domain protein EF_0829/AHA_3910; Region: EF_0829; TIGR03582
498216007722	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
498216007723	HTH domain; Region: HTH_11; pfam08279
498216007724	HTH domain; Region: HTH_11; pfam08279
498216007725	PRD domain; Region: PRD; pfam00874
498216007726	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
498216007727	active site
498216007728	P-loop; other site
498216007729	phosphorylation site [posttranslational modification]
498216007730	Class I aldolases; Region: Aldolase_Class_I; cl17187
498216007731	catalytic residue [active]
498216007732	PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; pfam03829
498216007733	Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612
498216007734	PTS system, glucitol/sorbitol-specific, IIBC component; Region: EIIBC-GUT; TIGR00825
498216007735	Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663
498216007736	PTS system enzyme II sorbitol-specific factor; Region: EII-GUT; pfam03608
498216007737	Glucitol operon activator protein (GutM); Region: GutM; pfam06923
498216007738	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
498216007739	HTH domain; Region: HTH_11; pfam08279
498216007740	PRD domain; Region: PRD; pfam00874
498216007741	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163
498216007742	active site
498216007743	phosphorylation site [posttranslational modification]
498216007744	sorbitol-6-phosphate 2-dehydrogenase; Provisional; Region: PRK06171
498216007745	classical (c) SDRs; Region: SDR_c; cd05233
498216007746	NAD(P) binding site [chemical binding]; other site
498216007747	active site
498216007748	L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193
498216007749	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398
498216007750	intersubunit interface [polypeptide binding]; other site
498216007751	active site
498216007752	Zn2+ binding site [ion binding]; other site
498216007753	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
498216007754	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
498216007755	active site
498216007756	motif I; other site
498216007757	motif II; other site
498216007758	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
498216007759	motif II; other site
498216007760	putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210
498216007761	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
498216007762	AP (apurinic/apyrimidinic) site pocket; other site
498216007763	DNA interaction; other site
498216007764	Metal-binding active site; metal-binding site
498216007765	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
498216007766	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
498216007767	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
498216007768	3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726
498216007769	active site
498216007770	dimer interface [polypeptide binding]; other site
498216007771	magnesium binding site [ion binding]; other site
498216007772	PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563
498216007773	active site
498216007774	P-loop; other site
498216007775	phosphorylation site [posttranslational modification]
498216007776	PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: PRK12997
498216007777	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
498216007778	active site
498216007779	phosphorylation site [posttranslational modification]
498216007780	putative L-ascorbate 6-phosphate lactonase; Provisional; Region: PRK11709
498216007781	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
498216007782	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
498216007783	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
498216007784	active site
498216007785	P-loop; other site
498216007786	phosphorylation site [posttranslational modification]
498216007787	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
498216007788	active site
498216007789	phosphorylation site [posttranslational modification]
498216007790	Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023
498216007791	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
498216007792	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
498216007793	Mga helix-turn-helix domain; Region: Mga; pfam05043
498216007794	PRD domain; Region: PRD; pfam00874
498216007795	PRD domain; Region: PRD; pfam00874
498216007796	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
498216007797	active site
498216007798	P-loop; other site
498216007799	phosphorylation site [posttranslational modification]
498216007800	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
498216007801	active site
498216007802	phosphorylation site [posttranslational modification]
498216007803	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
498216007804	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
498216007805	nucleotide binding site [chemical binding]; other site
498216007806	Glycosylasparaginase catalyzes the hydrolysis of the glycosylamide bond of asparagine-linked glycoproteins. This enzyme is an amidase located inside lysosomes. Mutation of this gene in humans causes a genetic disorder known as aspartylglycosaminuria (AGU)...; Region: Glycosylasparaginase; cd04513
498216007807	active site
498216007808	dimer interface [polypeptide binding]; other site
498216007809	catalytic nucleophile [active]
498216007810	M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888
498216007811	dipeptidase, putative; Region: dipeptidaselike; TIGR01887
498216007812	active site
498216007813	metal binding site [ion binding]; metal-binding site
498216007814	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
498216007815	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
498216007816	DNA-binding site [nucleotide binding]; DNA binding site
498216007817	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
498216007818	aspartate 4-decarboxylase; Region: asp_4_decarbox; TIGR03801
498216007819	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
498216007820	pyridoxal 5'-phosphate binding site [chemical binding]; other site
498216007821	homodimer interface [polypeptide binding]; other site
498216007822	catalytic residue [active]
498216007823	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
498216007824	Major Facilitator Superfamily; Region: MFS_1; pfam07690
498216007825	putative substrate translocation pore; other site
498216007826	Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119
498216007827	Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669
498216007828	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
498216007829	Coenzyme A binding pocket [chemical binding]; other site
498216007830	Predicted transcriptional regulators [Transcription]; Region: COG1695
498216007831	Transcriptional regulator PadR-like family; Region: PadR; cl17335
498216007832	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
498216007833	D-galactonate transporter; Region: 2A0114; TIGR00893
498216007834	putative substrate translocation pore; other site
498216007835	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
498216007836	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
498216007837	Coenzyme A binding pocket [chemical binding]; other site
498216007838	Nicotinamidase_ related amidohydrolases.  Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014
498216007839	Isochorismatase family; Region: Isochorismatase; pfam00857
498216007840	catalytic triad [active]
498216007841	conserved cis-peptide bond; other site
498216007842	AAA domain; Region: AAA_33; pfam13671
498216007843	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
498216007844	intersubunit interface [polypeptide binding]; other site
498216007845	active site
498216007846	zinc binding site [ion binding]; other site
498216007847	Na+ binding site [ion binding]; other site
498216007848	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
498216007849	classical (c) SDRs; Region: SDR_c; cd05233
498216007850	NAD(P) binding site [chemical binding]; other site
498216007851	active site
498216007852	PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830
498216007853	active site
498216007854	phosphorylation site [posttranslational modification]
498216007855	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
498216007856	active pocket/dimerization site; other site
498216007857	active site
498216007858	phosphorylation site [posttranslational modification]
498216007859	PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609
498216007860	PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613
498216007861	L-threonine dehydrogenase; Region: threonine_DH_like; cd08234
498216007862	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
498216007863	putative NAD(P) binding site [chemical binding]; other site
498216007864	catalytic Zn binding site [ion binding]; other site
498216007865	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
498216007866	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
498216007867	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
498216007868	putative active site [active]
498216007869	Protein of unknown function (DUF3923); Region: DUF3923; pfam13061
498216007870	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
498216007871	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
498216007872	non-specific DNA binding site [nucleotide binding]; other site
498216007873	salt bridge; other site
498216007874	sequence-specific DNA binding site [nucleotide binding]; other site
498216007875	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
498216007876	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
498216007877	active site
498216007878	catalytic site [active]
498216007879	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
498216007880	Low molecular weight phosphatase family; Region: LMWPc; cd00115
498216007881	active site
498216007882	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
498216007883	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
498216007884	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
498216007885	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
498216007886	dimer interface [polypeptide binding]; other site
498216007887	conserved gate region; other site
498216007888	putative PBP binding loops; other site
498216007889	ABC-ATPase subunit interface; other site
498216007890	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
498216007891	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
498216007892	dimer interface [polypeptide binding]; other site
498216007893	conserved gate region; other site
498216007894	putative PBP binding loops; other site
498216007895	ABC-ATPase subunit interface; other site
498216007896	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
498216007897	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
498216007898	Walker A/P-loop; other site
498216007899	ATP binding site [chemical binding]; other site
498216007900	Q-loop/lid; other site
498216007901	ABC transporter signature motif; other site
498216007902	Walker B; other site
498216007903	D-loop; other site
498216007904	H-loop/switch region; other site
498216007905	TOBE domain; Region: TOBE_2; pfam08402
498216007906	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
498216007907	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
498216007908	active site
498216007909	Isochorismatase family; Region: Isochorismatase; pfam00857
498216007910	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
498216007911	catalytic triad [active]
498216007912	conserved cis-peptide bond; other site
498216007913	ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051
498216007914	nudix motif; other site
498216007915	Uncharacterized conserved protein [General function prediction only]; Region: COG4111
498216007916	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
498216007917	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
498216007918	L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319
498216007919	active site
498216007920	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
498216007921	Beta-lactamase; Region: Beta-lactamase; pfam00144
498216007922	N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441
498216007923	N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007
498216007924	putative active site [active]
498216007925	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
498216007926	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
498216007927	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
498216007928	putative active site [active]
498216007929	PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830
498216007930	active site
498216007931	phosphorylation site [posttranslational modification]
498216007932	PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613
498216007933	PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609
498216007934	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
498216007935	putative phosphate binding site [ion binding]; other site
498216007936	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
498216007937	DHH family; Region: DHH; pfam01368
498216007938	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
498216007939	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
498216007940	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
498216007941	Coenzyme A binding pocket [chemical binding]; other site
498216007942	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
498216007943	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
498216007944	Coenzyme A binding pocket [chemical binding]; other site
498216007945	hypothetical protein; Validated; Region: PRK06769
498216007946	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
498216007947	active site
498216007948	motif I; other site
498216007949	motif II; other site
498216007950	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
498216007951	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
498216007952	putative NAD(P) binding site [chemical binding]; other site
498216007953	Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350
498216007954	Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053
498216007955	Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348
498216007956	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
498216007957	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
498216007958	Coenzyme A binding pocket [chemical binding]; other site
498216007959	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
498216007960	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
498216007961	Coenzyme A binding pocket [chemical binding]; other site
498216007962	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
498216007963	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
498216007964	Coenzyme A binding pocket [chemical binding]; other site
498216007965	ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553
498216007966	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
498216007967	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
498216007968	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
498216007969	transmembrane helices; other site
498216007970	hypothetical protein; Provisional; Region: PRK06446
498216007971	Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_4; cd05681
498216007972	metal binding site [ion binding]; metal-binding site
498216007973	dimer interface [polypeptide binding]; other site
498216007974	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
498216007975	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
498216007976	peptide binding site [polypeptide binding]; other site
498216007977	heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512
498216007978	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
498216007979	Soluble P-type ATPase [General function prediction only]; Region: COG4087
498216007980	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
498216007981	Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471
498216007982	putative dimer interface [polypeptide binding]; other site
498216007983	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
498216007984	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
498216007985	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
498216007986	protein binding site [polypeptide binding]; other site
498216007987	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
498216007988	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
498216007989	YycH protein; Region: YycI; pfam09648
498216007990	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863
498216007991	YycH protein; Region: YycH; pfam07435
498216007992	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002
498216007993	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
498216007994	dimerization interface [polypeptide binding]; other site
498216007995	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
498216007996	putative active site [active]
498216007997	heme pocket [chemical binding]; other site
498216007998	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
498216007999	dimer interface [polypeptide binding]; other site
498216008000	phosphorylation site [posttranslational modification]
498216008001	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
498216008002	ATP binding site [chemical binding]; other site
498216008003	Mg2+ binding site [ion binding]; other site
498216008004	G-X-G motif; other site
498216008005	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
498216008006	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
498216008007	active site
498216008008	phosphorylation site [posttranslational modification]
498216008009	intermolecular recognition site; other site
498216008010	dimerization interface [polypeptide binding]; other site
498216008011	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
498216008012	DNA binding site [nucleotide binding]
498216008013	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
498216008014	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
498216008015	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
498216008016	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
498216008017	substrate binding pocket [chemical binding]; other site
498216008018	membrane-bound complex binding site; other site
498216008019	hinge residues; other site
498216008020	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
498216008021	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
498216008022	dimer interface [polypeptide binding]; other site
498216008023	conserved gate region; other site
498216008024	putative PBP binding loops; other site
498216008025	ABC-ATPase subunit interface; other site
498216008026	argininosuccinate synthase; Provisional; Region: PRK13820
498216008027	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
498216008028	ANP binding site [chemical binding]; other site
498216008029	Substrate Binding Site II [chemical binding]; other site
498216008030	Substrate Binding Site I [chemical binding]; other site
498216008031	argininosuccinate lyase; Provisional; Region: PRK00855
498216008032	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
498216008033	active sites [active]
498216008034	tetramer interface [polypeptide binding]; other site
498216008035	Uncharacterized conserved protein [Function unknown]; Region: COG3589
498216008036	Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913
498216008037	Domain of unknown function (DUF3284); Region: DUF3284; pfam11687
498216008038	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
498216008039	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
498216008040	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
498216008041	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
498216008042	DNA-binding site [nucleotide binding]; DNA binding site
498216008043	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
498216008044	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
498216008045	active site
498216008046	P-loop; other site
498216008047	phosphorylation site [posttranslational modification]
498216008048	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
498216008049	active site
498216008050	methionine cluster; other site
498216008051	phosphorylation site [posttranslational modification]
498216008052	metal binding site [ion binding]; metal-binding site
498216008053	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
498216008054	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
498216008055	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677
498216008056	nudix motif; other site
498216008057	hypothetical protein; Provisional; Region: PRK06762
498216008058	Isochorismatase family; Region: Isochorismatase; pfam00857
498216008059	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
498216008060	catalytic triad [active]
498216008061	dimer interface [polypeptide binding]; other site
498216008062	conserved cis-peptide bond; other site
498216008063	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
498216008064	Homeodomain-like domain; Region: HTH_23; pfam13384
498216008065	Transposase; Region: DDE_Tnp_ISL3; pfam01610
498216008066	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
498216008067	Major Facilitator Superfamily; Region: MFS_1; pfam07690
498216008068	putative substrate translocation pore; other site
498216008069	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
498216008070	Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807
498216008071	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
498216008072	putative substrate translocation pore; other site
498216008073	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
498216008074	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
498216008075	active site
498216008076	catalytic tetrad [active]
498216008077	Domain of unknown function (DUF956); Region: DUF956; pfam06115
498216008078	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716
498216008079	PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065
498216008080	PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088
498216008081	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
498216008082	active pocket/dimerization site; other site
498216008083	active site
498216008084	phosphorylation site [posttranslational modification]
498216008085	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
498216008086	active site
498216008087	phosphorylation site [posttranslational modification]
498216008088	H+ Antiporter protein; Region: 2A0121; TIGR00900
498216008089	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
498216008090	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
498216008091	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
498216008092	non-specific DNA binding site [nucleotide binding]; other site
498216008093	salt bridge; other site
498216008094	sequence-specific DNA binding site [nucleotide binding]; other site
498216008095	transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716
498216008096	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
498216008097	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
498216008098	non-specific DNA binding site [nucleotide binding]; other site
498216008099	salt bridge; other site
498216008100	sequence-specific DNA binding site [nucleotide binding]; other site
498216008101	Helix-turn-helix domain; Region: HTH_19; pfam12844
498216008102	transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716
498216008103	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
498216008104	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
498216008105	substrate binding pocket [chemical binding]; other site
498216008106	membrane-bound complex binding site; other site
498216008107	hinge residues; other site
498216008108	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
498216008109	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
498216008110	dimer interface [polypeptide binding]; other site
498216008111	conserved gate region; other site
498216008112	putative PBP binding loops; other site
498216008113	ABC-ATPase subunit interface; other site
498216008114	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
498216008115	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
498216008116	Walker A/P-loop; other site
498216008117	ATP binding site [chemical binding]; other site
498216008118	Q-loop/lid; other site
498216008119	ABC transporter signature motif; other site
498216008120	Walker B; other site
498216008121	D-loop; other site
498216008122	H-loop/switch region; other site
498216008123	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
498216008124	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
498216008125	Protein of unknown function (DUF975); Region: DUF975; cl10504
498216008126	Uncharacterized conserved protein [Function unknown]; Region: COG3402
498216008127	Predicted membrane protein [Function unknown]; Region: COG3428
498216008128	Bacterial PH domain; Region: DUF304; pfam03703
498216008129	Bacterial PH domain; Region: DUF304; pfam03703
498216008130	Bacterial PH domain; Region: DUF304; cl01348
498216008131	Predicted ATPase [General function prediction only]; Region: COG3910
498216008132	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267
498216008133	Walker A/P-loop; other site
498216008134	ATP binding site [chemical binding]; other site
498216008135	Q-loop/lid; other site
498216008136	ABC transporter signature motif; other site
498216008137	Walker B; other site
498216008138	D-loop; other site
498216008139	H-loop/switch region; other site
498216008140	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
498216008141	Phosphotransferase enzyme family; Region: APH; pfam01636
498216008142	active site
498216008143	ATP binding site [chemical binding]; other site
498216008144	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
498216008145	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
498216008146	Walker A/P-loop; other site
498216008147	ATP binding site [chemical binding]; other site
498216008148	Q-loop/lid; other site
498216008149	ABC transporter signature motif; other site
498216008150	Walker B; other site
498216008151	D-loop; other site
498216008152	H-loop/switch region; other site
498216008153	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
498216008154	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
498216008155	substrate binding pocket [chemical binding]; other site
498216008156	membrane-bound complex binding site; other site
498216008157	hinge residues; other site
498216008158	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
498216008159	dimer interface [polypeptide binding]; other site
498216008160	conserved gate region; other site
498216008161	putative PBP binding loops; other site
498216008162	ABC-ATPase subunit interface; other site
498216008163	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
498216008164	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
498216008165	substrate binding pocket [chemical binding]; other site
498216008166	membrane-bound complex binding site; other site
498216008167	hinge residues; other site
498216008168	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
498216008169	dimer interface [polypeptide binding]; other site
498216008170	conserved gate region; other site
498216008171	putative PBP binding loops; other site
498216008172	ABC-ATPase subunit interface; other site
498216008173	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
498216008174	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
498216008175	Integral membrane protein DUF95; Region: DUF95; pfam01944
498216008176	MoxR-like ATPases [General function prediction only]; Region: COG0714
498216008177	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
498216008178	Walker A motif; other site
498216008179	ATP binding site [chemical binding]; other site
498216008180	Walker B motif; other site
498216008181	arginine finger; other site
498216008182	Protein of unknown function DUF58; Region: DUF58; pfam01882
498216008183	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
498216008184	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
498216008185	This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820
498216008186	putative ADP-binding pocket [chemical binding]; other site
498216008187	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
498216008188	maltose O-acetyltransferase; Provisional; Region: PRK10092
498216008189	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
498216008190	active site
498216008191	substrate binding site [chemical binding]; other site
498216008192	trimer interface [polypeptide binding]; other site
498216008193	CoA binding site [chemical binding]; other site
498216008194	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
498216008195	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
498216008196	active site
498216008197	motif I; other site
498216008198	motif II; other site
498216008199	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
498216008200	aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273
498216008201	Aspartase; Region: Aspartase; cd01357
498216008202	active sites [active]
498216008203	tetramer interface [polypeptide binding]; other site
498216008204	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430
498216008205	Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376
498216008206	Protein of unknown function (DUF2992); Region: DUF2992; pfam11208
498216008207	Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281
498216008208	Malic enzyme, N-terminal domain; Region: malic; pfam00390
498216008209	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
498216008210	putative NAD(P) binding site [chemical binding]; other site
498216008211	2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390
498216008212	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
498216008213	Homeodomain-like domain; Region: HTH_23; pfam13384
498216008214	Transposase; Region: DDE_Tnp_ISL3; pfam01610
498216008215	Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290
498216008216	Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565
498216008217	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
498216008218	active site
498216008219	phosphorylation site [posttranslational modification]
498216008220	intermolecular recognition site; other site
498216008221	dimerization interface [polypeptide binding]; other site
498216008222	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
498216008223	NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446
498216008224	Protein of unknown function (DUF1706); Region: DUF1706; pfam08020
498216008225	amino acid transporter; Region: 2A0306; TIGR00909
498216008226	Agrin NtA domain; Region: NtA; pfam03146
498216008227	Domain of unknown function (DUF3578); Region: DUF3578; pfam12102
498216008228	Domain of unknown function (DUF3883); Region: DUF3883; pfam13020
498216008229	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
498216008230	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
498216008231	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
498216008232	active site
498216008233	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
498216008234	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
498216008235	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
498216008236	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
498216008237	substrate binding pocket [chemical binding]; other site
498216008238	mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318
498216008239	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
498216008240	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
498216008241	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
498216008242	active site
498216008243	phosphorylation site [posttranslational modification]
498216008244	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
498216008245	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
498216008246	Mga helix-turn-helix domain; Region: Mga; pfam05043
498216008247	DNA-binding interface [nucleotide binding]; DNA binding site
498216008248	PRD domain; Region: PRD; pfam00874
498216008249	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
498216008250	active site
498216008251	P-loop; other site
498216008252	phosphorylation site [posttranslational modification]
498216008253	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163
498216008254	active site
498216008255	phosphorylation site [posttranslational modification]
498216008256	Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213
498216008257	PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851
498216008258	PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567
498216008259	active site
498216008260	P-loop; other site
498216008261	phosphorylation site [posttranslational modification]
498216008262	PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567
498216008263	active site
498216008264	P-loop; other site
498216008265	phosphorylation site [posttranslational modification]
498216008266	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
498216008267	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
498216008268	active site
498216008269	trimer interface [polypeptide binding]; other site
498216008270	allosteric site; other site
498216008271	active site lid [active]
498216008272	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
498216008273	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
498216008274	active site
498216008275	motif I; other site
498216008276	motif II; other site
498216008277	HlyD family secretion protein; Region: HlyD_2; pfam12700
498216008278	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
498216008279	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
498216008280	Walker A/P-loop; other site
498216008281	ATP binding site [chemical binding]; other site
498216008282	Q-loop/lid; other site
498216008283	ABC transporter signature motif; other site
498216008284	Walker B; other site
498216008285	D-loop; other site
498216008286	H-loop/switch region; other site
498216008287	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
498216008288	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
498216008289	FtsX-like permease family; Region: FtsX; pfam02687
498216008290	KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715
498216008291	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
498216008292	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
498216008293	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
498216008294	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
498216008295	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
498216008296	Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371
498216008297	Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172
498216008298	putative active site [active]
498216008299	metal binding site [ion binding]; metal-binding site
498216008300	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
498216008301	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
498216008302	metal binding site [ion binding]; metal-binding site
498216008303	dimer interface [polypeptide binding]; other site
498216008304	Protein of unknown function (DUF3815); Region: DUF3815; pfam12821
498216008305	Uncharacterized conserved protein [Function unknown]; Region: COG2966
498216008306	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
498216008307	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
498216008308	tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137
498216008309	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
498216008310	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
498216008311	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
498216008312	trmE is a tRNA modification GTPase; Region: trmE; cd04164
498216008313	G1 box; other site
498216008314	GTP/Mg2+ binding site [chemical binding]; other site
498216008315	Switch I region; other site
498216008316	G2 box; other site
498216008317	Switch II region; other site
498216008318	G3 box; other site
498216008319	G4 box; other site
498216008320	G5 box; other site
498216008321	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
498216008322	Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847
498216008323	jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation.  The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414
498216008324	G-X-X-G motif; other site
498216008325	R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644
498216008326	RxxxH motif; other site
498216008327	Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706
498216008328	60Kd inner membrane protein; Region: 60KD_IMP; cl00489
498216008329	ribonuclease P; Reviewed; Region: rnpA; PRK00499
498216008330	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399